307results about "Fluid controllers" patented technology

A thermopneumatic interface includes one or more pneumatic inlet ports in fluid communication with one or more pneumatic outlet ports and a cooling loop extending through the thermopneumatic interface. The cooling loop is configured to maintain the thermopneumatic interface at a baseline temperature. The one or more pneumatic outlet ports are configured to contact a surface of a microfluidic chip. Each pneumatic inlet port is configured to receive a change in pressure and provide the change in pressure to a corresponding pneumatic outlet port. The thermopneumatic interface is configured to maintain the microfluidic chip at the baseline temperature.

The present invention relates to a mini-pipette, and more particularly, to a mini-pipette which has capacity varying means that can vary the movement distance of a push button reciprocating in the outer body to generate suction force so that a variety of samples can be easily collected. The present invention provides a mini-pipette comprising: an outer body having a hollow movement space and a suction passage formed at a lower part of the outer body; a push button for generating negative or positive pressure in the suction passage while reciprocating in the movement space of the outer body; elastic means for elastically supporting the push button in the movement space; and a capacity varying means formed inside the outer body, for varying a movement distance of the push button in the movement space.

A non-contact deposition system includes a jetting assembly including at least one microvalve. The microvalve includes an orifice plate defining an orifice therethrough. An actuation beam is disposed in spaced relation to the orifice plate. The actuation beam includes a base portion and a cantilever portion extending from the base portion toward the orifice and movable between a closed position and an open position. A seal structure including a sealing member is disposed at an overlap of the cantilever portion. A fluid manifold is coupled to the microvalve and defines a fluid reservoir containing a pressurized fluid. When the actuation beam is in the closed position, the cantilever portion is positioned such that the seal structure seals the orifice to close the microvalve, and in the open position, fluid is dispensed from the orifice toward a substrate and deposited thereon.

The present disclosure provides apparatuses, systems, and methods for performing particle analysis through flow cytometry at comparatively high event rates and for gathering high resolution images of particles.

An electrowetting system for actuating droplets of a first composition and of a second composition. The system includes: a plurality of electrodes configured to manipulate droplets of fluid in a microfluidic space, each electrode being coupled to circuitry which applies driving voltages to the electrode; and a processing unit operably connected to a look up table correlating drive sequences to chemical species and at least one composition parameter. The pulse sequence of driving voltages to move at least one of the droplets contains at least three consecutive positive pulses or is positively biased.

The invention relates to a multi-channel lower part (20) for a fluid delivery device (100). The multi-channel lower part (20) comprises a housing (22) in which a plurality of parallel channels (31-38) for accommodating a fluid (40) are arranged, wherein each channel comprises a cylinder (39) which is delimited in axial direction by a displaceable piston (42), wherein end sections of the displaceable pistons (42) are accommodated in a piston operator (44) such that the pistons (42) are each displaced by the same distance by displacement of the piston operator (44). It is provided that a first accommodation (50) for a first carrier element (52) is formed on the housing (22) in which a plurality of channels (31-38) are accommodated and a second accommodation (60) for a second carrier element (62) is formed on the housing (22) in which a different number of channels (71-86) than the first carrier element (52) are accommodated. Here, the first carrier element (52) and the second carrier element (62) can each be reversibly releasably fixed in the housing (22).

Systems and methods for determining a concentration of a substance in a sample. In one embodiment, the system uses a device that cooperates with a container containing a sample mixed with a solution. The mixture comes into contact with a sensor that has been activated by the device, thereby allowing data signals to be received by the device through electrodes that are coupled to the sensor. The data signals are then analyzed and, based on the characteristics of the signal, a concentration of the substance can be estimated. After a single use, the container is sealed and can be disposed of properly to avoid further contact with the solution or the sample. In some embodiments, a solid sample is first processed in a second container before being mixed with the solution.

A safety cabinet includes an enclosure and at least one door to selectively seal the enclosure. The safety cabinet can be used to store, for example, flammable liquids, flammable waste, corrosive agents, pesticides, or combustible waste. The safety cabinet includes a heat-actuated damper including a body, a valve plate, and a pivot assembly. The valve plate is disposed within a passageway of the body such that the valve plate is movable between an open position and a closed position. The pivot assembly includes a biasing system adapted to bias the valve plate to the closed position and a fusible link interconnected between the body and the biasing system to limit movement of the valve plate from the open position to the closed position. The fusible link is configured to melt at a predetermined temperature, thereby allowing the biasing system to move the valve plate to the closed position.

The present invention discloses a non-contact type biological particle processing device and a biological particle processing device. [Solution] The bioparticle processing device includes a droplet generation chamber, a working chamber connected to the droplet generation chamber, and a sorting chamber connected to the working chamber. The droplet generation chamber receives a first liquid, bioparticles located in the first liquid, and a second liquid insoluble in the first liquid. The droplet generation chamber causes the flow of the second liquid to cross the first liquid, forming bioparticle droplets that flow toward the working chamber after passing through the bioparticles and a portion of the first liquid surrounding them, and the bioparticles are cultured or detected using the first liquid.

A chip module configured for use with a fluid sample processing system can include one or more assay devices arranged into one or more rows. The assay device(s) can include one or more wells configured to hold fluid therein and one or more aspiration channels connected to the well(s). The aspiration channel(s) can be configured to aspirate fluid from the bottoms or the sides of the well(s). The assay device(s) can be arranged within a frame in the chip module, which can be removable from the fluid sample processing system. This chip module can also include one or more trenches beneath the aspiration channel(s), the trench(es) being configured to facilitate the aspiration of fluid from multiple wells. A hydrophobic material can be included in the aspiration channel(s) and / or trench(es) to hold the fluid therein without the fluid passing through the aspiration channel(s) during analytic measurements on the fluid.

The present invention provides a sample solution separation device with a small dead volume. A sample solution separation device (101) comprises: a plurality of microchambers (105); a flow path (104) that connects the plurality of microchambers (105); a first opening (102) that is an inlet to the flow path (104) of a sample solution; a valve (103) that is provided between the first opening (102) and the plurality of microchambers (105); a second opening (107) that is an inlet to the flow path of a separation liquid separating between the plurality of microchambers (105) in which the sample solution is accommodated, and is provided on the opposite side of the first opening with the plurality of microchambers (105) in between; and a solid phase (106) provided between the second opening (107) and the plurality of microchambers (105). The solid phase (106) is air-permeable, hydrophobic to the sample solution, and permeable to the separation liquid.

Provided herein is a biological substance treatment method in which a flow cell is prepared, the flow cell including a chamber array device including a plurality of chambers and a cover body defining a flow path communicating with an opening of the plurality of chambers and provided in common for the plurality of chambers.

The present invention provides microfluidic devices capable of generating a flow of fluids within a chamber. The flow of fluids mix within the chamber to form a gradient of concentrations. The chamber is capable of accepting a cell culture and is accessible to retrieve the cell culture. The microfluidic devices are compatible with standard laboratory microscopes for optical analyses of the chamber.

The present invention relates to a multi-channel lower component (20) for a liquid delivery device (100), comprising: - a piston actuator (40) for simultaneously moving a plurality of pistons (75); - a plurality of receiving volumes (80, 81, 82, 83, 84, 85, 86, 87) arranged parallel to each other for receiving fluid, wherein each receiving volume (80, 81, 82, 83, 84, 85, 86, 87) is defined by one of the pistons (75); - a housing (22) having a spring chamber (15) for receiving a spring (52) for the piston actuator (40) and a receiving chamber (17) for receiving the plurality of receiving volumes for receiving fluid. The invention relates to a fluid delivery device (100) having a multi-channel lower component (20) in a contact area (60) at or within a spring chamber (15), wherein: a first guide (54) for a piston actuator (40) or a component (56, 58) connected to the piston actuator (40) is provided in the spring chamber (15), and a second guide (68) for a piston actuator (40) or a component (102, 104) connected to the piston actuator (40) is provided on the inner side of the housing (22) facing the receiving chamber (17). The invention further relates to a fluid delivery device (100) having such a multi-channel lower component (20).

The invention provides a device for detecting an analyte in a sample, comprising: a cavity for receiving a test element, the test element having a first position and a second position within the cavity, when in the first position the test element does not contact a fluid sample, when in the second position the test element contacts a fluid sample.

Various embodiments are provided for a centrifugal microfluidic device. In one example, the centrifugal microfluidic device includes a plurality of layers forming a body. The device can further include a plurality of sample preparation domains disposed in parallel within the body. The individual sample preparation domains include a lysis chamber configured to receive a sample from a swab and to receive a lysate solution. Additionally, the domains include a metering chamber configured to receive a lysate from the lysis chamber, where the metering chamber is connected to the lysis chamber via a first microfluidic channel having a laser valve. The domains can further include an overflow chamber configured to receive overflow of the lysate from the metering chamber. The domains can further include a bisulfite conversion portion of the sample preparation domain connected to the metering chamber via a second microfluidic channel.

A manually actuated chromatography device comprising a chamber for receiving a liquid sample, a pump with a metering valve, and a chromatography element, wherein the pump moves a predetermined volume of liquid from the sample chamber to the chromatography element.

A method of label-free sorting a plurality of particles using a system, including obtaining impedance signals of a particle as the particle is in motion toward an actuation region in a microfluidic device, determining if the particle is a target particle based on a comparison of one or more impedance-based gatings with the impedance signals of the particle, determining an actuation time for the particle, the actuation time being determined based on the impedance signals of the particle, and at the actuation time, deflecting the particle away from a default channel in the microfluidic device in response to determining that the particle is a target particle. The system comprises a microfluidic channel extending through a first detection region and a second detection region to the actuation region, the first and second detection regions having electrodes to obtain impedance signals of the particle.

The present invention uses a gel layer to coat and / or separate one or more aqueous reaction mixtures in a reaction vessel. The gel layer can prevent reagents or reaction products from coming into contact with the atmosphere. The gel layer can also separate multiple aqueous reaction mixtures, preventing them from coming into contact with each other until the gel layer is broken. An oil layer can be inserted directly beneath the gel layer. A micropipette tip can be inserted to penetrate the gel layer and deliver a solution, such as a sample, beneath the gel layer. The gel layer can also be broken using a micropipette tip or an inert rod, mixing the aqueous reaction mixtures above and below the layer. The gel layer can also be broken by selective heat application or by the movement of magnetic beads. Multiple gel layers separating multiple aqueous reagent mixtures can be broken in a predetermined sequence for a series of bioprocess steps.

The present invention is directed to a cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, in particular a blood sample, comprising a cartridge body having at least one measurement cavity formed therein and having at least one probe element arranged in said at least one measurement cavity for performing a test on said sample liquid; and a cover being attachable on said cartridge body; wherein said cover covers at least partially said at least one measurement cavity and forms a retaining element for retaining said probe element in a predetermined position within said at least one measurement cavity. The invention is directed to a measurement system and a method for measuring viscoelastic characteristics of a sample liquid.

A pipette 10 for aspirating and / or dispensing liquids comprising a pipette tip 100 and a plunger 200. The pipette tip has a proximal end 101 and a distal end 102 defining a longitudinal axis 1 therebe

Mixing a liquid sample and at least one reagent in microchannel of a microfluidic device includes preparing a segment of the liquid sample in contact with the reagent(s) within the microchannel. The liquid segment has a volume of 2 μL or less and defines a proximal gas-liquid interface and a distal liquid-gas interface. The gas of the proximal gas-liquid interface is in gaseous communication with a distal liquid-gas interface of another amount of liquid disposed proximally to the liquid segment within the microchannel of the microfluidic channel. The gas of the distal liquid-gas interface is disposed distally to the liquid segment within the microfluidic channel. With the liquid of the liquid segment in contact with the reagent(s) within the microchannel, the gas of the distal liquid-gas interface and / or the gas of the proximal gas-liquid interface is / are oscillated at an acoustic frequency to induce mixing of the liquid and the reagent(s).

The present invention is directed to a system and method for a research instrument device. A method of purifying extracellular vesicles (“EVs”) is disclosed wherein a biological sample including EVs is obtained and applied to a fluidic cell in an array of fluidic cells of a multistage dielectrophoretic (“DEP”) filter system. The DEP filter system comprises a semiconductor array comprising a plurality of electrodes. The DEP filter system is disposed within a fluidics system; wherein the fluidics system is configured to move at least one fluid across the semiconductor array of the DEP filter system.

A system and method are provided that include the steps of hydrating a lyophilized reagent and homogenizing the hydrated reagent under the control of a control circuit that implements a hydration and homogenization protocol. A lyophilized reagent nozzle sipper that includes a distal tip extends into a lyophilized reagent well such that the distal tip does not contact the associated lyophilized reagent, and a specified amount of hydration fluid is automatically aspirated from a corresponding hydration reservoir by a corresponding sipper and dispensed into the lyophilized reagent well based on a hydration and homogenization protocol implemented by the control circuit. The method may also include extending the lyophilized reagent nozzle sipper into the lyophilized reagent well such that the distal tip contacts the hydrated reagent and automatically aspirating and discharging the hydrated reagent based on a hydration and homogenization protocol implemented by the control circuit.

A cartridge may include a plurality of inspection chambers to provide a space in which a reaction solution is accommodated. The cartridge may also include a supply channel to provide a passage for the reaction solution supplied from an external source to flow to the plurality of inspection chambers. The cartridge may further include a plurality of resistance channels through which the reaction solution discharged from the plurality of inspection chambers flows. The plurality of resistance channels may be respectively connected to the plurality of inspection chambers to allow gas inside the inspection chambers to be discharged to the outside. A second resistance value which is the sum of the resistance values of the plurality of resistance channels may be greater than a first resistance value which is the sum of resistance values of the supply channel and the plurality of inspection chambers.

An exemplary method and system is disclosed that facilitate the integration of multiplexed single-cell impedance cytometry in a high throughput format, which can be deployed upstream from microfluidic sample preparation and / or downstream to microfluidic cell separation. In exemplary method and system may employ impedance-based quantification of cell electrophysiology on the same microfluidic chip (i.e., “on-chip”) to provide distinguishing phenotypic information on the sample, without the need for additional sample handling, preparation or dilution steps as would be needed for other flow cytometry techniques.