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11539results about "Fluid controllers" patented technology
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System and apparatus for sequential processing of analytes
InactiveUS6969488B2Bioreactor/fermenter combinationsBiological substance pretreatmentsAnalyteMicroparticle
An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside of a flow chamber where steps of an analytical process are carried out by delivering a sequence of processing reagents to the microparticles by a fluidic system under microprocessor control. In response to such process steps, an optical signal is generated at the surface of each microparticle which is characteristic of the interaction between the analyte carried by the microparticle and the delivered processing reagent. The plurality of analytes are simultaneously analyzed by collecting and recording images of the optical signals generated by all the microparticles in the planar array. A key feature of the invention is the correlation of the sequence of optical signals generated by each microparticle in the planar array during the analytical process.
Owner:SOLEXA
Methods and apparatus for analyzing polynucleotide sequences
The present invention provides an apparatus for analyzing the sequences of polynucleotides. The apparatus comprises (a) flow cell which has at least one microfabricated multilayer elastomeric synthesis channel; and (b) an inlet port and an outlet port. The inlet port and outlet ports are in fluid communication with the flow cell for flowing fluids into and through the flow cell.
Owner:CALIFORNIA INST OF TECH
Microfluidic devices
InactiveUS20080003142A1Quickly and effectively and inexpensivelyDielectrophoresisHeating or cooling apparatusEngineering
Owner:BIO RAD LAB INC
Droplet-based assay system
ActiveUS20100173394A1Easy CalibrationImprove accuracy and reliabilityBioreactor/fermenter combinationsBiological substance pretreatmentsAssayBiology
Owner:LAWRENCE LIVERMORE NAT SECURITY LLC
Apparatus for manipulating droplets by electrowetting-based techniques
InactiveUS6911132B2Improve controllabilityImprove accuracyBurnersElectrostatic separatorsElectricityControl manner
An apparatus is provided for manipulating droplets. The apparatus is a single-sided electrode design in which all conductive elements are contained on one surface on which droplets are manipulated. An additional surface can be provided parallel with the first surface for the purpose of containing the droplets to be manipulated. Droplets are manipulated by performing electrowetting-based techniques in which electrodes contained on or embedded in the first surface are sequentially energized and de-energized in a controlled manner. The apparatus enables a number of droplet manipulation processes, including merging and mixing two droplets together, splitting a droplet into two or more droplets, sampling a continuous liquid flow by forming from the flow individually controllable droplets, and iterative binary or digital mixing of droplets to obtain a desired mixing ratio.
Owner:DUKE UNIV
Nucleic acid amplification utilizing microfluidic devices
InactiveUS6960437B2Bioreactor/fermenter combinationsBiological substance pretreatmentsRegulation temperatureEngineering
The present invention provides microfluidic devices and methods using the same in various types of thermal cycling reactions. Certaom devices include a rotary microfluidic channel and a plurality of temperature regions at different locations along the rotary microfluidic channel at which temperature is regulated. Solution can be repeatedly passed through the temperature regions such that the solution is exposed to different temperatures. Other microfluidic devices include an array of reaction chambers formed by intersecting vertical and horizontal flow channels, with the ability to regulate temperature at the reaction chambers. The microfluidic devices can be used to conduct a number of different analyses, including various primer extension reactions and nucleic acid amplification reactions.
Owner:CALIFORNIA INST OF TECH
Method, apparatus and article for microfluidic control via electrowetting, for chemical, biochemical and biological assays and the like
InactiveUS7163612B2Low costElectrostatic separatorsSludge treatmentOff the shelfLiquid-crystal display
An active matrix microfluidic platform employs thin film transistor active (“TFT”) matrix liquid crystal display technology to manipulate small samples of fluid for chemical, biochemical, or biological assays without moving parts, for example, using a two-dimensional matrix array of drive electrodes. The active matrix microfluidic platform may employ existing active matrix addressing schemes and / or commercial “off-the-shelf” animation software to program assay protocols. A feedback subsystem may determine an actual location of a fluid in the microfluidic structure, and provides location information to for display, for example, on an active matrix display, and / or to control movement of one or more fluid bodies in the microfluidic structure.
Owner:KECK GRADUATE INST OF APPLIED LIFE SCI
Immunoassay device with improved sample closure
ActiveUS20050054078A1Bioreactor/fermenter combinationsBiological substance pretreatmentsCapillary TubingEngineering
An apparatus and method for sealing a fluid sample collection device, comprising: loading a fluid sample collection device with a fluid sample, said device comprising a housing having at least one substantially planar surface that includes an orifice in fluid communication with an internal fluid sample holding chamber which terminates at an internal capillary stop; and slidably moving a sealing element over at least a portion of said substantially planar surface in a way that displaces any excess fluid sample away from the orifice, seals the fluid sample within said holding chamber, and inhibits the fluid sample from prematurely breaking through the internal capillary stop.
Owner:ABBOTT POINT CARE
Apparatus and methods for analyte measurement and immuno assay
ActiveUS20030170881A1Avoid disadvantagesBioreactor/fermenter combinationsBiological substance pretreatmentsPoint of careOrganism
The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand / ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.
Owner:ABBOTT POINT CARE
Methods of analyzing polymers using a spatial network of fluorophores and fluorescence resonance energy transfer
InactiveUS6263286B1Easy to analyze and useMicrobiological testing/measurementLaboratory glasswaresEnergy transferResonance
The present invention relates to methods and apparatuses for analyzing molecules, particularly polymers, and molecular complexes with extended or rod-like conformations. In particular, the methods and apparatuses are used to identify repetitive information in molecules or molecular ensembles, which is interpreted using an autocorrelation function in order to determine structural information about the molecules. The methods and apparatuses of the invention are used for, inter alia, determining the sequence of a nucleic acid, determining the degree of identity of two polymers, determining the spatial separation of specific sites within a polymer, determining the length of a polymer, and determining the velocity with which a molecule penetrates a biological membrane.
Owner:U S GENOMICS INC
Microfluidic system with integrated permeable membrane
InactiveUS20050266582A1Analysis using chemical indicatorsMaterial analysis by observing effect on chemical indicatorChemical reactionCompound (substance)
A microfluidic system for performing chemical reactions or biochemical, biological, or chemical assays utilizing a microfabricated device or “chip.” The system may include, among others, an integrated membrane fabricated from a chemically inert material whose permeability for gases, liquids, cells, and specific molecules, etc. can be selected for optimum results in a desired application.
Owner:CYTODISCOVERY
Droplet Libraries
Owner:BIO RAD LAB INC
Microfluidic Devices and Methods of Use in The Formation and Control of Nanoreactors
InactiveUS20100137163A1Material nanotechnologyCompound screeningHigh-Throughput Screening AssaysEmulsion
The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. Such methods can include labeling a library of compounds by emulsifying aqueous solutions of the compounds and aqueous solutions of unique liquid labels on a microfluidic device, which includes a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids, whereby each compound is labeled with a unique liquid label, pooling the labeled emulsions, coalescing the labeled emulsions with emulsions containing a specific cell or enzyme, thereby forming a nanoreactor, screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, and decoding the liquid label, thereby identifying a single compound from a library of compounds.
Owner:BIO RAD LAB INC
Methods and apparatuses for analyzing polynucleotide sequences
Methods for high speed, high throughput analysis of polynucleotide sequences, and apparatuses with which to carry out the methods are provided in the invention.
Owner:CALIFORNIA INST OF TECH
Method and devices for extremely fast DNA replication by polymerase chain reactions (PCR)
InactiveUS6180372B1Shorten cycle timeHigh sensitivityBioreactor/fermenter combinationsNanotechPolymerase LBiological materials
The invention concerns methods and instruments for fast, selective replication of deoxyribonucleic acid (DNA) from biomaterial through the known polymerase chain reaction (PCR), working in individual duplication thermocycles. The invention consists of extremely brief cycle times of only a few seconds for the PCR reactions, generated, on the one hand, by reaction chambers for the reception of the reaction solution constructed of a pattern of fine capillaries in close proximity to heating and cooling elements in order to optimally accelerate the temperature setting in the reaction solution for the three temperature phases of the PCR duplication cycles and, on the other hand, by keeping the flow rates in the capillaries to a minimum during the amplification phase so that the polymerase reaction is not disturbed. The capillary pattern can be simply produced by means of microsystern technology.
Owner:BRUKER FRANZEN ANALYTIK
Integrated optoelectronic read head and fluidic cartridge useful for nucleic acid sequencing
ActiveUS20130260372A1Bioreactor/fermenter combinationsBiological substance pretreatmentsWide fieldEngineering
A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir; (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.
Owner:ILLUMINA INC
Device and method for pressure-driven plug transport and reaction
InactiveUS7129091B2Well mixedQuick mixMaterial nanotechnologySequential/parallel process reactionsPressure.driveCarrier fluid
Owner:UNIVERSITY OF CHICAGO
Apparatus and methods for analyte measurement and immunoassay
ActiveUS7419821B2Bioreactor/fermenter combinationsBiological substance pretreatmentsPoint of careEngineering
Owner:ABBOTT POINT CARE
Reading devices and assay devices for use therewith
InactiveUS6235241B1Accurate placementFacilitate and control formationAnalysis using chemical indicatorsMaterial analysis by observing effect on chemical indicatorCombined useEngineering
An assay result reader, for use in conjunction with an assay device comprising a porous liquid-permeable carrier in the form of a strip or sheet through the thickness of which electromagnetic radiation is transmissible, the carrier including a detection zone in which an assay result is revealed by specific binding of a detectable material directly or indirectly to a binding agent immobilized in the detection zone, detection of the detectable material being effected by determining the extent to which electromagnetic radiation transmitted through the thickness of said carrier is attenuated by the presence of the detectable material bound in the detection zone.
Owner:INVERNESS SWITZERLAND GMBH
Nucleic acid amplification with continuous flow emulsion
InactiveUS20050227264A1Rapid and economical mannerReduce nozzle cloggingHeating or cooling apparatusFlow mixersMicroreactorGenetic Materials
Embodiments of the present invention are directed to methods and devices / systems for amplifying genetic material and may include providing a water-in-oil emulsion in a continuous flow. The emulsion may include a plurality of water droplets comprising microreactors. Each of the plurality of microreactors may include a single bead capable of capturing a nucleic acid template, a single species nucleic acid template and sufficient reagents to amplify the copy number of the nucleic acid template. The method also includes flowing the emulsion across a first temperature zone and a second lower temperature zone to thermally process the microreactors to amplify the nucleic acid template by polymerase chain reaction.
Owner:454 LIFE SCIENCES CORP
Assay cartridges and methods for point of care instruments
InactiveUS20070031283A1Reduce complexityImprove performanceAnalysis using chemical indicatorsHeating or cooling apparatusPoint of careAssay
Devices and methods are provided for performing a test to detect and / or quantify the presence of an analyte of interest within a sample using a portable instrument.
Owner:BIOVERIS CORP
Method for separating analyte from a sample
InactiveUS6893879B2Improve elution efficiencyBioreactor/fermenter combinationsBiological substance pretreatmentsSporeChemical reaction
An analyte is separated from a fluid sample by introducing the sample into a cartridge having an extraction chamber containing capture material for capturing the analyte. The sample is forced to flow through the extraction chamber to capture the analyte with the capture material in the extraction chamber. The captured analyte is then eluted from the extraction chamber by forcing an elution fluid to flow through the extraction chamber. The cartridge may optionally include a lysing region for lysing sample components (e.g., cells spores, or microorganisms), a waste chamber for storing waste fluid, and reaction or detection chambers for chemically reacting or detecting the eluted analyte.
Owner:CEPHEID INC
Microfluidic devices and methods of use
InactiveUS20020127736A1Lessening oscillation in velocityReduce oscillation amplitudeSludge treatmentFixed microstructural devicesElastomerThin membrane
A microfluidic device comprises pumps, valves, and fluid oscillation dampers. In a device employed for sorting, an entity is flowed by the pump along a flow channel through a detection region to a junction. Based upon an identity of the entity determined in the detection region, a waste or collection valve located on opposite branches of the flow channel at the junction are actuated, thereby routing the entity to either a waste pool or a collection pool. A damper structure may be located between the pump and the junction. The damper reduces the amplitude of oscillation pressure in the flow channel due to operation of the pump, thereby lessening oscillation in velocity of the entity during sorting process. The microfluidic device may be formed in a block of elastomer material, with thin membranes of the elastomer material deflectable into the flow channel to provide pump or valve functionality.
Owner:CALIFORNIA INST OF TECH
Device for displacement of small liquid volumes along a micro-catenary line by electrostatic forces
ActiveUS7052244B2Improve guidancePrevent evaporationPump componentsLaboratory glasswaresElectricityElectrical control
The invention relates to a device for displacement of at least a small volume of liquid (5) under the effect of an electrical control, including a substrate (1) provided with first electrically conducting means (2), the device also comprising second electrically conducting means (3) arranged facing the first electrically conducting means (2), the first electrically conducting means and the second electrically conducting means possibly being connected to electrical power supply means to enable the application of electrostatic forces to the small liquid volume (5). The second electrically conducting means include at least one conducting wire (3) arranged parallel to the substrate and at a fixed distance from the substrate to enable displacement of the small volume of liquid (5) along said conducting wire (3) under the effect of the applied electrostatic forces.
Owner:COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
In vitro evolution in microfluidic systems
ActiveUS20060078888A1High activitySpeed up the processSequential/parallel process reactionsFlow mixersGene productGenetic element
The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step is under microfluidic control. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention.
Owner:PRESIDENT & FELLOWS OF HARVARD COLLEGE +1
Single molecule amplification and detection of DNA length
InactiveUS20050042639A1Reliable resultsImprove reliabilityHeating or cooling apparatusMicrobiological testing/measurementStatistical analysisDNA
Methods and systems for performing single molecule amplification for detection, quantification and statistical analysis of nucleic acids are provided. Methods and systems are provided for determining and quantifying lengths of nucleic acids of interest.
Owner:CAPLIPER LIFE SCI INC
Analytical system and method
InactiveUS6071478AImprove standardizationSimple interfaceWithdrawing sample devicesMaterial analysis by optical meansBiomedical engineering
An analytical or preparatory system comprised as a base unit, an adapter, and a substrate. The adapter is attached to an attachment region on the base unit, and the substrate is attached to an attachment region on the adapter. The adapter permits the base unit to be interfaced with a wide variety of different substrates to perform chemical and biological analytical analyses and preparatory procedures.
Owner:CALIPER TECH
Compartmentalised screening by microfluidic control
InactiveUS20050221339A1Rapid and high-throughput screeningLow costCompound screeningSequential/parallel process reactionsCompound (substance)Drug development
The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a) compartmentalising the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsule; and b) identifying the compound which binds to or modulates the activity of the target; wherein at least one step is performed under microfluidic control. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.
Owner:PRESIDENT & FELLOWS OF HARVARD COLLEGE +1
Disposable vacuum filtration apparatus capable of detecting microorganisms and particulates in liquid samples
InactiveUS6913152B2Increase valueEasy to disassemblePreparing sample for investigationUltrafiltrationMicroorganismWrinkle skin
A vacuum filtration apparatus (900) for detecting microorganisms and particulates in liquid samples. The apparatus includes a base (901), an absorbent pad (991), a filter (990), a funnel (930), and a lid (960). The funnel is releasably attached to the base, and may contain an integral flexible seal for releasably sealing the filter to the base. The outer wall of the lid may be segmented to make it flexible, this flexibility allows it to be releasably attached to the funnel or the base. The apparatus is designed so that any funnel will fit any base, and any lid will fit any base or any funnel when all parts are manufactured to normal tolerances. The apparatus may be configured to to keep the filter wrinkle free in both the dry and wet states.
Owner:FOXX LIFE SCI
Microfluidic nucleic acid analysis
ActiveUS20050053952A1Bioreactor/fermenter combinationsBiological substance pretreatmentsCDNA libraryCells isolation
Nucleic acid from cells and viruses sampled from a variety of environments may purified and expressed utilizing microfluidic techniques. In accordance with one embodiment of the present invention, individual or small groups of cells or viruses may be isolated in microfluidic chambers by dilution, sorting, and / or segmentation. The isolated cells or viruses may be lysed directly in the microfluidic chamber, and the resulting nucleic acid purified by exposure to affinity beads. Subsequent elution of the purified nucleic acid may be followed by ligation and cell transformation, all within the same microfluidic chip. In one specific application, cell isolation, lysis, and nucleic acid purification may be performed utilizing a highly parallelized microfluidic architecture to construct gDNA and cDNA libraries.
Owner:CALIFORNIA INST OF TECH
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