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3190 results about "Genetic Materials" patented technology
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Genetic material. Definition. noun. The genetic material of a cell or an organism refers to those materials found in the nucleus, mitochondria and cytoplasm, which play a fundamental role in determining the structure and nature of cell substances, and capable of self-propagating and variation.
Inbred corn line LH283BtMON810
InactiveUS6852915B2Other foreign material introduction processesFermentationBiotechnologyGenetic Materials
An inbred corn line, designated LH283BtMON810, is disclosed. The invention relates to the seeds of inbred corn line LH283BtMON810, to the plants of inbred corn line LH283BtMON810 and to methods for producing a corn plant, either inbred or hybrid, by crossing the inbred line LH283BtMON810 with itself or another corn line. The invention further relates to methods for producing a corn plant containing in its genetic material one or more transgenes and to the transgenic plants produced by that method and to methods for producing other inbred corn lines derived from the inbred LH283BtMON810.
Owner:HOLDENS FOUND SEEDS
Nucleic acid amplification with continuous flow emulsion
InactiveUS20050227264A1Rapid and economical mannerReduce nozzle cloggingHeating or cooling apparatusFlow mixersMicroreactorGenetic Materials
Embodiments of the present invention are directed to methods and devices / systems for amplifying genetic material and may include providing a water-in-oil emulsion in a continuous flow. The emulsion may include a plurality of water droplets comprising microreactors. Each of the plurality of microreactors may include a single bead capable of capturing a nucleic acid template, a single species nucleic acid template and sufficient reagents to amplify the copy number of the nucleic acid template. The method also includes flowing the emulsion across a first temperature zone and a second lower temperature zone to thermally process the microreactors to amplify the nucleic acid template by polymerase chain reaction.
Owner:454 LIFE SCIENCES CORP
Transgenic plant event detection
ActiveUS8700336B2Reduce in quantityExtension of timeMicrobiological testing/measurementClimate change adaptationGenetic MaterialsTransgene
The present invention relates to detection of materials derived from transgenic plant events. In particular, the invention provides methods, reagents, kits and reference materials for detecting the presence or absence in a sample of genetic material derived from and attributable to select transgenic plant events.
Owner:SCIENSANO
Nucleic acid amplification with continuous flow emulsion
InactiveUS7927797B2Rapid and economical mannerReduce nozzle cloggingHeating or cooling apparatusFlow mixersMicroreactorGenetic Materials
Embodiments of the present invention are directed to methods and devices / systems for amplifying genetic material and may include providing a water-in-oil emulsion in a continuous flow. The emulsion may include a plurality of water droplets comprising microreactors. Each of the plurality of microreactors may include a single bead capable of capturing a nucleic acid template, a single species nucleic acid template and sufficient reagents to amplify the copy number of the nucleic acid template. The method also includes flowing the emulsion across a first temperature zone and a second lower temperature zone to thermally process the microreactors to amplify the nucleic acid template by polymerase chain reaction.
Owner:454 LIFE SCIENCES CORP
System and method for cleaning noisy genetic data and determining chromosome copy number
ActiveUS20080243398A1Significant resultImprove fidelityData processing applicationsMicrobiological testing/measurementGenetic MaterialsEmbryo
Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Genetic material from the target individual is acquired, amplified and the genetic data is measured using known methods. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment of the invention, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment of the invention, the chromosome copy number can be determined from the measured genetic data of a single or small number of cells, with or without genetic information from one or both parents. In another embodiment of the invention, these determinations are made for the purpose of embryo selection in the context of in-vitro fertilization. In another embodiment of the invention, the genetic data can be reconstructed for the purposes of making phenotypic predictions.
Owner:NATERA
Methods and compositions for detecting genetic material
InactiveUS20110159499A1Sugar derivativesMicrobiological testing/measurementGenetic MaterialsPolynucleotide
This invention provides compositions and methods for detecting differences in copy number of a target polynucleotide. In some cases, the methods and compositions provided herein are useful for diagnosis of fetal genetic abnormalities, when the starting sample is maternal tissue (e.g., blood, plasma). The methods and materials described apply techniques for allowing detection of small, but statistically significant, differences in polynucleotide copy number.
Owner:BIO RAD LAB INC
Pluripotent stem cells derived without the use of embryos or fetal tissue
InactiveUS20030113910A1New breed animal cellsArtificial cell constructsPluripotential stem cellGerm layer
Owner:STEMA
Permanent magnet solenoid pump for an implantable therapeutic substance delivery device
InactiveUS7288085B2Energy efficiencyPharmaceutical delivery mechanismMedical devicesGenetic MaterialsElectromagnetic pump
A medical device known as an implantable therapeutic substance delivery device is configured for implanting in humans to deliver a therapeutic substance such as pharmaceutical compositions, genetic materials, and biologics to treat a variety of medical conditions such as pain, spastisity, cancer, and many other conditions. The therapeutic substance delivery device has a permanent magnet solenoid pump that is energy efficient, accurate, small, compatible with therapeutic substances, and has many other improvements. The implantable therapeutic substance delivery device has a housing, a therapeutic substance reservoir, a power source, electronics, and a permanent magnet solenoid pump. The therapeutic substance reservoir is configured to contain a therapeutic substance and is coupled to the housing. The power source is carried in the housing to power the electronics and solenoid pump. The electronics are coupled to the solenoid pump and the solenoid pump is coupled to the therapeutic substance reservoir. The permanent magnet solenoid pump is configured for pumping therapeutic substance from the therapeutic substance reservoir through an infusion outlet at a programmed infusion rate. Many embodiments of the permanent magnet solenoid pump and its methods of operation are possible.
Owner:MEDTRONIC INC
Microfluidic integrated microarrays for biological detection
InactiveUS20050095602A1Reduction in sample preparationHigh sensitivityBioreactor/fermenter combinationsBiological substance pretreatmentsGenetic MaterialsGene
Disclosed are microflulidic chips that include a plurality of vias; a functionalized porous polymer monolith capable of being in fluid communication with a via; a microarray capable of being in fluid communication with the functionalized porous polymer monolith; and an observation port through which at least one target disposed within the microarray is capable of being detected. The disclosed microfluidic chips contain microarrays that can be effectively coupled to functionalized porous polymer monoliths for capturing and concentrating sample nucleic acids. Also disclosed are microfluidic chips containing microarray probes having observation ports that enable the preparation of microarrays and the detection of targets. These microfluidic chips are capable of capturing and concentrating genetic material for the analysis and identification of biological organisms, such as so-called “threat genes” from chimeric bioweapons.
Owner:SANDIA NAT LAB
System and method for cleaning noisy genetic data and determining chromosome copy number
ActiveUS8515679B2Improve fidelityData processing applicationsMicrobiological testing/measurementGenetic MaterialsEmbryo
Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Genetic material from the target individual is acquired, amplified and the genetic data is measured using known methods. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment of the invention, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment of the invention, the chromosome copy number can be determined from the measured genetic data of a single or small number of cells, with or without genetic information from one or both parents. In another embodiment of the invention, these determinations are made for the purpose of embryo selection in the context of in-vitro fertilization. In another embodiment of the invention, the genetic data can be reconstructed for the purposes of making phenotypic predictions.
Owner:NATERA
Materials and methods for increasing isoprenoid production in cells
InactiveUS7129392B2Other foreign material introduction processesIsomerasesPhytoene synthesisOpen reading frame
Owner:KUEHNLE AGROSYST COMPANY +1
System for administering a combination of therapies to a body lumen
The invention provides a system which comprises a medical device that delivers a combination of therapies. These therapies include the administration of radiation, biologically active materials, cryotherapy, and thermotherapy. The present invention is also directed to a method of treating body lumen surfaces using the system of the invention. A system is provided for delivering a biologically active material to a surface of a body lumen being exposed to a radioactive source. In one aspect, the system comprises an implantable medical device which has two opposing ends, each having a surface, and a middle portion. The two opposing ends comprise a biologically active material and the middle portion of the medical device is substantially free of any biologically active material. In another aspect, the system delivers a genetic material to a surface of a body lumen which is exposed to a radioactive source. Another system is provided for treating a surface of a body lumen in which the system comprises an implantable medical device which comprises a biologically active material and a device for applying a therapy source to the parts of the body lumen surface that are in contact with the opposing ends of the medical device. The therapy source may be a cryotherapy source or a thermotherapy source.
Owner:BOSTON SCI SCIMED INC
Lettuce cultivar 21-0406127-B
InactiveUS7371930B1Quality improvementOther foreign material introduction processesTissue cultureGenetic MaterialsTransgene
A lettuce cultivar, designated 21-0406127-B, is disclosed. The invention relates to the seeds of lettuce cultivar 21-0406127-B, to the plants of lettuce cultivar 21-0406127-B and to methods for producing a lettuce plant by crossing the cultivar 21-0406127-B with itself or another lettuce cultivar. The invention further relates to methods for producing a lettuce plant containing in its genetic material one or more transgenes and to the transgenic lettuce plants and plant parts produced by those methods. This invention also relates to lettuce cultivars or breeding cultivars and plant parts derived from lettuce cultivar 21-0406127-B, to methods for producing other lettuce cultivars, lines or plant parts derived from lettuce cultivar 21-0406127-B and to the lettuce plants, varieties, and their parts derived from the use of those methods. The invention further relates to hybrid lettuce seeds, plants, and plant parts produced by crossing cultivar 21-0406127-B with another lettuce cultivar.
Owner:SHAMROCK SEED
Soybean cultivar 7013345
ActiveUS7642416B2Other foreign material introduction processesFermentationGenetic MaterialsGenetically modified soybean
A soybean cultivar designated 7013345 is disclosed. The invention relates to the seeds of soybean cultivar 7013345, to the plants of soybean 7013345, to plant parts of soybean cultivar 7013345 and to methods for producing a soybean plant produced by crossing soybean cultivar 7013345 with itself or with another soybean variety. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. This invention also relates to soybean cultivars or breeding cultivars and plant parts derived from soybean variety 7013345, to methods for producing other soybean cultivars, lines or plant parts derived from soybean cultivar 7013345 and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants and plant parts produced by crossing the cultivar 7013345 with another soybean cultivar.
Owner:MERTEC
Composition comprising gas-filled microcapsules for ultrasound mediated delivery
InactiveUS20090041833A1Efficient deliveryPowder deliveryDrug compositionsLipid formationActive agent
Composition comprising gas filled microcapsules and a bioactive agent, useful for an ultrasound-mediated delivery of said bioactive agent. The microcapsules comprise a relatively stiff shell of polymeric or lipid material and have in particular a resistance to a mechanical index of at least 0.15, while the bioactive agent is substantially unbound to the shell of the microcapsules. The composition of the invention is particularly suitable for effectively delivering a genetic material into a cell, upon exposure of the composition to a level of acoustic pressure capable of destroying a portion of the microcapsules and releasing the gas contained therein.
Owner:BRACCO RES USA
Process for Chromosomal Engineering Using a Novel Dna Repair System
This invention relates to chromosomal engineering via DNA repair process. The process of the invention comprises the steps of: 1) submitting at least one source of biological activity, e.g. Deinococcus radiodurans, to radiation, desiccation and / or chemical treatment liable to damage the DNA, so as to substantially shatter its chromosomes into short fragments; 2) annealing complementary single strand tails extended by the synthesis templated on partially overlapping DNA fragments of said shattered chromosomes; 4) converting the resulting long linear DNA intermediates into intact circular chromosomes, by means of a RecA dependent homologous recombination; whereas at least one foreign source of genetic material, e.g. DNA, can be introduced during steps 2 and / or 3; and 4) optionally separating and collecting the recombined chromosomes thus obtained.
Owner:DEINOVE SA
Canola cultivar NQC02CNX21
ActiveUS20060225146A1DegreeImprove nutritional qualityOther foreign material introduction processesFermentationBrassicaGenetic Materials
A canola cultivar designated NQC02CNX21 is disclosed. The invention relates to the seeds of canola cultivar NQC02CNX21, to the plants of canola NQC02CNX21, to plant parts of canola cultivar NQC02CNX21 and to methods for producing a canola plant produced by crossing canola cultivar NQC02CNX21 with itself or with another canola line. The invention also relates to methods for producing a canola plant containing in its genetic material one or more transgenes and to the transgenic canola plants and plant parts produced by those methods. This invention also relates to canola cultivars or breeding cultivars and plant parts derived from canola cultivar NQC02CNX21, to methods for producing other canola cultivars, lines or plant parts derived from canola cultivar NQC02CNX21 and to the canola plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid canola seeds, plants and plant parts produced by crossing the canola cultivar NQC02CNX21 with another canola cultivar.
Owner:CORTEVA AGRISCIENCE LLC
Lettuce cultivar ‘blade’
InactiveUS7371934B1Quality improvementTissue cultureOther foreign material introduction processesGenetic MaterialsTransgene
A lettuce cultivar, designated ‘Blade’, is disclosed. The invention relates to the seeds of lettuce cultivar ‘Blade’, to the plants of lettuce cultivar ‘Blade’ and to methods for producing a lettuce plant by crossing the cultivar ‘Blade’ with itself or another lettuce cultivar. The invention further relates to methods for producing a lettuce plant containing in its genetic material one or more transgenes and to the transgenic lettuce plants and plant parts produced by those methods. This invention also relates to lettuce cultivars or breeding cultivars and plant parts derived from lettuce cultivar ‘Blade’, to methods for producing other lettuce cultivars, lines or plant parts derived from lettuce cultivar ‘Blade’ and to the lettuce plants, varieties, and their parts derived from the use of those methods. The invention further relates to hybrid lettuce seeds, plants, and plant parts produced by crossing cultivar ‘Blade’ with another lettuce cultivar.
Owner:ENZA ZADEN BEHEER BV
Soybean variety XB33S03
InactiveUS6855875B1Plant genotype modificationPlant cellsGenetic MaterialsGenetically modified soybean
According to the invention, there is provided a novel soybean variety, designated XB33S03. This invention thus relates to the seeds of soybean variety XB33S03, to the plants of soybean XB33S03 to plant parts of soybean variety XB33S03 and to methods for producing a soybean plant produced by crossing soybean variety XB33S03 with another soybean plant, using XB33S03 as either the male or the female parent. This invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. This invention also relates to soybean varieties or breeding varieties and plant parts derived from soybean variety XB33S03, to methods for producing other soybean varieties, lines or plant parts derived from soybean variety XB33S03 and to the soybean plants, varieties, and their parts derived from use of those methods. This invention further relates to soybean seeds, plants, and plant parts produced by crossing the soybean variety XB33S03 with another soybean variety preferably as part of a breeding program.
Owner:PIONEER HI BRED INT INC
Molecules for Gene Delivery and Gene Therapy, and Methods of Use Thereof
InactiveUS20090221684A1Organic active ingredientsPeptide/protein ingredientsGene deliveryGenetic Materials
One aspect of the present invention relates to a synthetic non-viral vector composition for gene therapy. Another aspect of the invention relates to the use of the composition for in vitro, ex vivo and / or in vivo transfer of genetic material. The invention also encompasses a pharmaceutical composition (useful for delivery of nucleic acids to a cell), containing a non-cationic amphiphilic molecule or macro-molecule; or a cationic amphiphilic molecule or macromolecule that transforms from a cationic entity to an anionic, neutral, or zwitterionic entity upon a chemical, photochemical, or biological reaction. Another aspect of the invention relates to multicationic compounds that are composed of three or more amino acids. The present invention also relates to the use of the pharmaceutical composition for delivery of nucleic acids to a cell. Moreover, the invention encompasses the non-viral vector compositions tethered to a surface. The surface-tethered compositions are useful for the delivery of nucleic acids to cells in contact with the surface. An additional embodiment of the invention relates to a hydrogel comprising a composition of the invention, and methods of using same for the delivery of genetic material to a cell.
Owner:TRUSTEES OF BOSTON UNIV
Soybean cultivar S060182
ActiveUS7345226B2Improve nutritional qualityOther foreign material introduction processesFermentationGenetic MaterialsGenetically modified soybean
A soybean cultivar designated S060182 is disclosed. The invention relates to the seeds of soybean cultivar S060182, to the plants of soybean S060182, to plant parts of soybean cultivar S060182 and to methods for producing a soybean plant produced by crossing soybean cultivar S060182 with itself or with another soybean variety. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. This invention also relates to soybean cultivars or breeding cultivars and plant parts derived from soybean variety S060182, to methods for producing other soybean cultivars, lines or plant parts derived from soybean cultivar S060182 and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants and plant parts produced by crossing the cultivar S060182 with another soybean cultivar.
Owner:STINE SEED FARM +1
Medical device with coating for capturing genetically-altered cells and methods for using same
InactiveUS20050025752A1Good biocompatibilityDecreases or inhibits tissue-based excessive intimal hyperplasia and restenosisBiocideMaterial nanotechnologyAntigenProgenitor
Therapeutic and drug delivery systems are provided in the form of medical devices with coatings for capturing and immobilizing target cells such as circulating progenitor or genetically-altered mammalian cells in vivo. The genetically-altered cells are transfected with genetic material for expressing a marker gene and a therapeutic gene in a constitutively or controlled manner. The marker gene is a cell membrane antigen not found in circulating cells in the blood stream and therapeutic gene encodes a peptide for the treatment of disease, such as, vascular disease and cancer. The coating on the medical device may be a biocompatible matrix comprising at least one type of ligand, such as antibodies, antibody fragments, other peptides and small molecules, which recognize and bind the target cells. The therapeutic and / or drug delivery systems may be provided with a signal source such as activator molecules for stimulating the modified cells to express and secrete the desired marker and therapeutic gene products.
Owner:ORBUSNEICH MEDICAL PTE LTD
Mutation analysis using mass spectrometry
InactiveUS6503710B2Rapid and economic sample preparationAccurate massSamplingSugar derivativesChemical treatmentFree form
The invention presents a method for examining genetic material (deoxyribonucleic acid, DNA) to detect the presence of pre-known mutations, especially single nucleotide polymorphisms (SNP), using mass spectrometry with ionization by matrix-assisted laser desorption (MALDI). The invention uses nucleoside triphosphates with modified sites for the method of primer extension in a duplicating, enzymatic reaction and at least partially removal of primers from the extension product, in combination with product neutralization by chemical treatment of the modified sites, so that the resulting DNA products can be, by using special matrix materials, preferredly ionized in an adduct-free form over other constituents in the reaction solution without any further cleaning. The method is particularly suitable for simultaneous identification of several mutations by multiplexing.
Owner:BRUKER DALTONIK GMBH
Genetic immunization with cationic lipids
InactiveUS6890554B2Elicit immune responseOrganic active ingredientsSugar derivativesLipid formationEpitope mapping
A method for immunization using genetic material is disclosed. Compositions for genetic immunization comprising cationic lipids and polynucleotides are also disclosed. Methods for using genetic immunization to produce polyclonal and monoclonal antibodies are also disclosed. A method for epitope mapping is also disclosed.
Owner:LIFE TECH CORP
Canola cultivar NQC02CNX13
InactiveUS20060225159A1DegreeImprove nutritional qualityOther foreign material introduction processesFermentationGenetic MaterialsRapeseed
A canola cultivar designated NQC02CNX13 is disclosed. The invention relates to the seeds of canola cultivar NQC02CNX13, to the plants of canola NQC02CNX13, to plant parts of canola cultivar NQC02CNX13 and to methods for producing a canola plant produced by crossing canola cultivar NQC02CNX13 with itself or with another canola line. The invention also relates to methods for producing a canola plant containing in its genetic material one or more transgenes and to the transgenic canola plants and plant parts produced by those methods. This invention also relates to canola cultivars or breeding cultivars and plant parts derived from canola cultivar NQC02CNX13, to methods for producing other canola cultivars, lines or plant parts derived from canola cultivar NQC02CNX13 and to the canola plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid canola seeds, plants and plant parts produced by crossing the canola cultivar NQC02CNX13 with another canola cultivar.
Owner:DOW AGROSCIENCES LLC
Inbred corn line BB14
ActiveUS7511199B2Improve nutritional qualityModified waxy contentPlant tissue cultureHorticulture methodsGenetic MaterialsTransgene
Owner:KWS SAAT SE +1
Functional synthetic molecules and macromolecules for gene delivery
The present invention describes a synthetic non-viral vector composition for gene therapy and the use of such compositions for in vitro, ex vivo and / or in vivo transfer of genetic material. The invention proposes a pharmaceutical composition containing 1) a non-cationic amphiphilic molecule or macromolecule and its use for delivery of nucleic acids or 2) a cationic amphiphilic molecule or macromolecule that transforms from a cationic entity to an anionic, neutral, or zwitterionic entity by a chemical, photochemical, or biological reaction and its use for delivery of nucleic acids. Moreover this invention describes the use of these non-viral vector compositions in conjunction with a surface to mediate the delivery of nucleic acids. An additional embodiment is the formation of a hydrogel with these compositions and the use of this hydrogel for the delivery of genetic material. A further embodiment of this invention is the use of a change in ionic strength for the delivery of genetic material.
Owner:FIFTH BASE
Method and apparatus for quantification of DNA sequencing quality and construction of a characterizable model system using reed-solomon codes
Data extracted from fluorosphore responses of fluorophore labeled bases in genetic material used in sequencing of unknown fragments from a defined set of for example a model system are converted into a class of block codes that are then employed in a computer-based process to compare and correct preliminary calls of calls of the categorically known genetic material. In a specific embodiment, the Reed-Solomon codes are employed to identify one or more errors as may occur in a finite block of codes. The methodology is also useful to identify elements of a real system containing known elements in the form of a tag. Reed-Solomon sensors may be employed with and in addition to other types of genome sensors.
Owner:COMPLETE GENOMICS INC
Targeted chromosomal mutagenasis using zinc finger nucleases
Owner:UNIV OF UTAH RES FOUND
Soybean cultivar S050163
ActiveUS7078600B1Improve nutritional qualityOther foreign material introduction processesFermentationGenetic MaterialsGenetically modified soybean
A soybean cultivar designated S050163 is disclosed. The invention relates to the seeds of soybean cultivar S050163, to the plants of soybean S050163, to plant parts of soybean cultivar S050163 and to methods for producing a soybean plant produced by crossing soybean cultivar S050163 with itself or with another soybean variety. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. This invention also relates to soybean cultivars or breeding cultivars and plant parts derived from soybean variety S050163, to methods for producing other soybean cultivars, lines or plant parts derived from soybean cultivar S050163 and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants and plant parts produced by crossing the cultivar S050163 with another soybean cultivar.
Owner:STINE SEED FARM +1
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