84 results about "Amphiphilic molecule" patented technology

A membrane assembly comprising: (a) a porous support; and (b) a plurality of membrane mimetic structures on a surface of the support; wherein the membrane mimetic structures comprise: (i) a channel protein which comprises a transmembrane domain having a hydrophobic surface, and (ii) one or more amphiphilic molecules; and wherein the one or more amphiphilic molecules form a ring structure around the hydrophobic surface of said transmembrane domain of the channel protein.

The invention discloses a two-dimensional heterostructure silver-loaded mesoporous copper nanosheet catalyst, a preparation method thereof and application of the two-dimensional heterostructure silver-loaded mesoporous copper nanosheet catalyst in electro-catalytic synthesis of alanine, amphiphilic molecules N-(2-mercaptoethyl)-N, N-dimethyldocosyl-1-ammonium chloride are dissolved in water, then metal precursors silver nitrate and copper nitrate are added, stirring is carried out, and the two-dimensional heterostructure silver-loaded mesoporous copper nanosheet catalyst is obtained. Finally, hydrazine hydrate is added for step-by-step reduction, and the two-dimensional heterostructure silver-mesoporous copper nanosheet (Ag-meso-Cu) catalyst is obtained. The Ag-meso-Cu catalyst prepared by the method disclosed by the invention has an asymmetric two-dimensional mesoporous structure and shows enhanced electro-catalysis alanine synthesis performance, the Faraday efficiency of alanine synthesis is up to 89.84%, and the yield is up to 0.23 mmol h <-1 > mg <-1 >. The preparation of the two-dimensional heterostructure nanosheet with a multilevel structure is realized by utilizing a simple liquid phase method, and a new strategy is provided for electrochemical synthesis of amino acid under a mild condition.

Provided is a temperature-responsive fluorescent particle comprising at least one type of fluorescent molecule in a molecular assembly comprising and constituted by at least one type of amphiphilic molecule, wherein the fluorescent molecule emits fluorescence when the molecular assembly is in the liquid phase and it is quenched when the molecular assembly is in the solid phase, due to a temperature-responsive solid-liquid phase transition, so that fluorescence emission and quenching of the fluorescent molecule are reversibly switched in a temperature responsive manner. Also provided is a temperature-responsive fluorescent probe comprising the temperature-responsive fluorescent particle the surface of which is modified with a biomolecule recognition element, and methods for detecting and quantitatively determining a biomolecule with the temperature-responsive fluorescent probe.

The present invention discloses a method for preparing a high-concentration terbinafine hydrochloride aqueous solution, belonging to the technical field of pharmaceutical preparations. The preparation method comprises the following steps: (1) mixing a water-soluble molecule containing a benzene ring with terbinafine hydrochloride, adding water and stirring evenly, and performing a homogenization treatment to obtain a dispersion of a water-soluble molecule-terbinafine conjugate containing a benzene ring; and (2) adding a water-soluble non-ionic amphiphilic molecule to the dispersion, and continuing the homogenization treatment to obtain a terbinafine hydrochloride aqueous solution. The present invention is beneficial in that: through the p-p interaction between the benzene ring of the water-soluble molecule containing a benzene ring and the naphthalene ring in the terbinafine molecule, and the synergistic effect of the water-soluble non-ionic amphiphilic molecule, the complete dissolution of terbinafine in water is achieved at the molecular level. The concentration of the prepared terbinafine hydrochloride aqueous solution is as high as 6wt%, which solves the problem that terbinafine is difficult to dissolve in water without adding a solubilizer.

The present disclosure relates to a method of forming electrical signal sensor. The method includes the following operations. An oxidoreductase and an amphiphilic molecule are dissolved into a solvent to form a solution, in which the amphiphilic molecule includes alkyl sulfuric acid, alkyl sulfate, alkyl sulfonic acid, alkyl sulfonate, alkyl ammonium, alkyl ammonium salt, alkyl phosphoric acid, alkyl phosphate, alkyl carboxylic acid, alkyl carboxylate, alkylboronic acid, alkylborate, or combinations thereof. The solution is coated on an electrode layer. The solution is dried.

The preparation method of the high-temperature-creep-resistant nano-composite pressure vessel steel comprises the following steps that a lead sulfide precursor is dissolved in an organic solvent, and heating reaction is conducted under the inert gas condition to generate lead sulfide quantum dots; mixing quantum dots with amphiphilic molecules, and performing ultrasonic emulsification to form a quantum dot colloidal solution; mixing the quantum dot colloidal solution with supercritical carbon dioxide to form a homogeneous fluid phase; the steel matrix is placed in a high-pressure reaction kettle, the homogeneous fluid phase is introduced, permeation is conducted for 2-4 h under the conditions that the pressure is 10-15 MPa and the temperature is 50-70 DEG C, and a steel billet is obtained; the steel billet is placed in hot isostatic pressing equipment, heat preservation and pressure maintaining are conducted for 1-2 h in the inert gas environment under the conditions that the pressure ranges from 150 MPa to 200 MPa and the temperature ranges from 800 DEG C to 900 DEG C, and then the steel billet is cooled to the room temperature; semiconductor quantum dots are introduced into a metal matrix, atomic-scale interface strengthening is achieved through the quantum effect and the supercritical fluid permeation technology, and the steady-state creep rate of the material at the temperature of 600 DEG C can be reduced to 1 / 10 of that of a traditional process by combining the microcosmic strengthening advantage of the quantum dots and the macroscopic permeation advantage of supercritical fluid.

The present application relates to the technical field of nanoprobes, and particularly relates to a near-infrared fluorescence / magnetic resonance dual-mode probe and a preparation method and application thereof. The present application adopts a Brij98 amphiphilic molecule to wrap an IR824Et-PhDTA-Gd near-infrared fluorescence / magnetic resonance dual-response molecule to prepare the probe, so that the probe has an absorption wavelength of 650-850 nm, generates a fluorescence signal under excitation of 785 nm laser, and the generated fluorescence wavelength can reach 1000 nm, which is in a near-infrared region (780-1700 nm); the probe has good positive magnetic resonance response characteristics, and a longitudinal relaxation rate (r1) of the probe is 28 mM ‑1 s ‑1 , which is 7 times of that of a clinically used Magnevist; the probe can be applied in the fields of fluorescence and / or magnetic resonance imaging, and has a wide application prospect. The preparation method of the near-infrared fluorescence / magnetic resonance dual-mode probe is simple in operation and low in cost.

The invention discloses a water-based photoresponse type rosin-based aggregation-induced emission amphiphilic molecule as well as a preparation method and application thereof. The molecular structural formula of the water-based light response type rosin-based AIE amphiphilic molecule is shown in the specification, or n ranges from 15 to 30. According to the water-based light-responsive rosin-based AIE amphiphilic molecule, a tetraphenyl ethylene or cyanostilbene fluorophore is introduced into the anhydride part of maleopimaric acid through an imidization reaction, and groups such as sodium carboxylate, amino acid sodium or polyethylene glycol are introduced into the carboxylic acid position to prepare the water-based light-responsive rosin-based AIE amphiphilic molecule. The solid of the molecule has blue fluorescence emission, and can be used for dyes or solid anti-counterfeiting materials. A photoresponsive AIE aqueous solution is prepared by using the amphiphilic molecule alone or compounding the amphiphilic molecule with dodecyl polyoxyethylene ether, and the photoresponsive AIE aqueous solution can be used for water-based anti-counterfeiting ink, cell imaging or 4-nitrophenol detection and the like.

The invention relates to the technical field of solar cells, in particular to a perovskite solar cell based on 2-aminoethyl sulfuric acid interface modification and a preparation method thereof, and the perovskite solar cell sequentially comprises a conductive substrate layer, an electron transport layer, a perovskite light absorption layer, a hole transport layer and a back electrode layer from bottom to top; an interface between the electron transport layer and the perovskite light absorption layer is modified through amphoteric molecules, the amphoteric molecules are 2-aminoethyl sulfuric acid, and the molecular formula of the amphoteric molecules is C2H7NO4S. Wherein sulfate ions in the amphoteric molecules can passivate oxygen vacancy defects in a manner of forming covalent bonds with the oxygen vacancy defects on the surface of the metal oxide, and ammonium ions in the amphoteric molecules can passivate organic acupoints of the perovskite in a manner of forming ionic bonds with PbI3 <-> in the perovskite; meanwhile, the interface energy level of the electron transport layer / perovskite light absorption layer and the quality of the perovskite thin film are improved, and finally the purpose of improving the efficiency and the stability of the perovskite solar cell is achieved.

The application relates to a bacterial aggregation and killing bifunctional photosensitizer aggregate and a preparation method thereof. An AIE photosensitizer and a glycosyl amphiphilic molecule are added into a phosphate buffer solution according to a certain molar ratio, stirred uniformly, and then left to form the photosensitizer aggregate spontaneously. The preparation process of the photosensitizer aggregate constructed by the method is simple, convenient to operate, and has good repeatability. Experimental results prove that the constructed aggregate can induce bacterial aggregation, realize efficient killing of pathogenic bacteria, and further improve the sterilization efficiency when light is applied.

The invention belongs to the field of fuel additive preparation, and relates to a preparation method of an alcohol-based oxygen-containing fuel additive. In order to solve the problems that an existing carbonic ester additive is relatively low in boiling point and is not matched with a diesel distillation range, the invention develops a special catalyst and a preparation process for preparing an alcohol-based oxygen-containing fuel additive, the catalyst takes a hierarchical pore molecular sieve as a carrier, and a potassium alcoholate active component and an amphiphilic molecule linking agent are introduced. Then catalyzing the ester exchange reaction of dimethyl carbonate and butanol by using the catalyst to generate a mixture of methyl butyl carbonate, dibutyl carbonate and the like, and fractionating to obtain the alcohol-based oxygen-containing fuel additive which has a proper boiling point and can be used for remarkably improving the oxygen content of the fuel.

Polymer dots comprising a functionalized fluorescent polymer and an amphiphilic molecule are provided.

The invention discloses a PD-L1 monoclonal antibody delivery system as well as a preparation method and application thereof, and belongs to the technical field of medicines. The preparation method comprises the following steps: coupling amino groups of BPA-PEG9 and a PD-L1 monoclonal antibody through NHS (N-hydroxysuccinimide) esterification to form BPA6-aPDL1; the preparation method comprises the following steps: grafting a glucose derivative maltomimetic acid MA of o-benzene dihydroxyl to a lipid-like amphiphilic molecule PEG (Polyethylene Glycol) (1.5 k-DSPE) through an amido bond to form MA4-PEG (1.5 k-DSPE), namely MA4-PD; then, the BPA6-aPDL1 reacts with the MA4-PD through a boric acid ester bond, and finally, the delivery system MB-aPDL1 is formed. The delivery system not only can successfully deliver the PD-L1 to a tumor site across a blood brain barrier, but also can accurately release the PD-L1 monoclonal antibody, so that the PD-L1 monoclonal antibody is only enriched in a tumor region, the residence time of the antibody is prolonged, the tumor anchoring capability of the antibody is improved, and the occurrence of immune-related adverse events is remarkably reduced.

A nanoparticle vaccine composition includes a shell including one or more amphiphilic molecules and one or more hapten molecules, where at least one amphiphilic molecule is conjugated to the hapten molecule, and a substantially hydrophobic core including an immunogenic protein, a vaccine adjuvant, one or more inert biocompatible materials, or a combination of two or more thereof, where the core is encapsulated in the shell to form a nanoparticle.

The invention belongs to the technical field of tumor treatment, and particularly relates to application of PBI-TPE-11 in preparation of a product for indicating drug resistance of tumor cells. The technical problem to be solved by the invention is to provide a new method for knowing the drug resistance of tumor cells. The technical scheme of the invention is application of PBI-TPE-11 in preparation of a product for indicating drug resistance of tumor cells. The invention provides a substance PBI-TPE-11 which can be used for indicating the drug resistance of tumor cells. The PBI-TPE-11 is an amphiphilic molecule, can be self-assembled and gathered in cells, and can emit fluorescence under the action of exciting light; and the gene can also be identified by ABCG2 and transferred out of the cell. Therefore, the drug resistance of the tumor cells is indicated by observing and comparing the signal of the cell fluorescence and the change of the cell fluorescence.

The invention discloses a preparation method of a high-concentration terbinafine hydrochloride aqueous solution, and belongs to the technical field of pharmaceutical preparations. The preparation method comprises the following steps: (1) mixing a water-soluble molecule containing a benzene ring with terbinafine hydrochloride, adding water, uniformly stirring, and homogenizing to obtain a water-soluble molecule-terbinafine coupling body dispersion liquid containing the benzene ring; and (2) adding water-soluble nonionic amphiphilic molecules into the dispersion liquid, and continuing homogenizing treatment to obtain the terbinafine hydrochloride aqueous solution. The terbinafine preparation has the beneficial effects that through the p-p interaction between the benzene ring of the water-soluble molecule containing the benzene ring and the naphthalene ring in the terbinafine molecule and the synergistic effect of the water-soluble nonionic amphiphilic molecule, the complete dissolution of terbinafine in water is realized on the molecular level; the concentration of the prepared terbinafine hydrochloride aqueous solution is as high as 6wt%, and the problem that terbinafine is difficult to dissolve in water under the condition that a solubilizer is not added is solved.

The invention discloses a dipotassium phosphate synergist for plant-based food and a preparation method of the dipotassium phosphate synergist. The dipotassium phosphate synergist for the plant-based food comprises the following components in percentage by mass: 15%-40% of nanocrystallized dipotassium phosphate; 30%-60% of composite plant colloid, wherein the composite plant colloid is prepared by cross-linking natural anionic polysaccharide and nonionic polysaccharide; 3%-8% of an interface function auxiliary agent, wherein the interface function auxiliary agent is prepared by adopting a layered film, nano-scale filling particles and molecular-scale chelating metal ions in a synergistic manner; 10%-25% of a microporous carrier; and 0.5%-3% of an ion migration inhibitor, which is prepared by synergistically using amphiphilic molecules and cationic polypeptides. The dipotassium phosphate synergistic system with the intelligent response characteristic is constructed through three technical innovations of nanostructure design, biological interface engineering and supercritical processing, and the problems of water separation, ion migration and texture stability of dipotassium phosphate in a plant protein matrix can be solved through a multi-component synergistic effect.

The present invention discloses a water-soluble tetrazine, a tetrazine membrane probe and a preparation method thereof. The water-soluble tetrazine is not only easy to synthesize, but also, after being connected with hydrophobic BCy, makes the tetrazine membrane probe an amphiphilic molecule, capable of being connected to the cell membrane surface for fluorescence imaging. Moreover, the tetrazine group can undergo an in-situ bioorthogonal reaction with a dienophile, thereby changing the hydrophilicity and hydrophobicity of the tetrazine membrane probe, so that the tetrazine membrane probe can stay on the cell membrane surface for a longer time or enter the hydrophobic environment inside the cell membrane more quickly, thereby flexibly adjusting the targeting ability of the tetrazine membrane probe to the cell membrane.

The application provides a paclitaxel molecular umbrella delivery system prodrug, a preparation method and application thereof. The paclitaxel molecular umbrella delivery system prodrug comprises a molecular umbrella target head part composed of two surface amphiphilic molecules connected by spermidine, a paclitaxel drug part, and a connecting group connecting the molecular umbrella target head part and the paclitaxel drug part through a disulfide bond; wherein the surface amphiphilic molecule is selected from cholic acid, deoxycholic acid or a sodium sulfonate thereof. Compared with paclitaxel, the paclitaxel molecular umbrella delivery system prodrug has significantly improved water solubility, lower toxicity to normal cells than free paclitaxel, and significantly improved safety; and the paclitaxel molecular umbrella delivery system prodrug has the following characteristics in a physiological environment: releasing active drugs in the high GSH / ROS microenvironment of tumor cells; and maintaining a prodrug state in normal cells.

The application relates to the field of mineral processing, and discloses a pyrrhotite collector, which comprises a mercaptan group collector, 5-30 parts, an amide group collector, 5-30 parts, a surfactant, 2-10 parts, an organic solvent, 20-50 parts, water, 20-60 parts, a collector aid, 1-15 parts, and a pH regulator, 1-10 parts. The pyrrhotite is efficiently collected by introducing the mercaptan group collector and the amide group collector into the collector. The collector molecules have high affinity with the active sites on the surface of the pyrrhotite, so that the collection efficiency of the mineral is greatly improved, and the technical purpose of significantly improving the ore recovery rate is achieved. Meanwhile, the amphiphilic molecules are used as the surfactant, including an anionic surfactant and a cationic surfactant. The surfactants can effectively adjust the properties of the mineral surface, and the selective separation of the pyrrhotite and other impurity minerals is realized.

The application belongs to the technical field of tumor treatment, and particularly relates to application of PBI-TPE-11 in preparation of a product for indicating drug resistance of tumor cells. The application aims to provide a new method for understanding drug resistance of tumor cells. The technical scheme of the application is that PBI-TPE-11 is applied in preparation of a product for indicating drug resistance of tumor cells. The application provides a substance PBI-TPE-11 which can be used for indicating drug resistance of tumor cells. The PBI-TPE-11 is an amphiphilic molecule which can self-assemble and aggregate in cells, and emit fluorescence under the action of excitation light; and can also be recognized by ABCG2 and transported to the outside of cells. Therefore, drug resistance of tumor cells can be indicated by observing and comparing signals and changes of cell fluorescence.

The present invention provides for an amphiphilic molecule having a profluorinated alkyl-methyloligoethyleneoxide structure. The present invention also provides for an electrolyte composition comprising an amphiphilic molecule of the present invention, an electrolyte solvent, and a lithium salt.

The application discloses a kind of polyethylene glycol cupped aromatic compounds and its preparation method and application, the polyethylene glycol cupped aromatic compound is connected by diazotization reaction by skeleton molecule and the diamino benzoic acid with metaposition protection, and then by upper end free carboxyl modification hydrophilic polyethylene glycol molecule to construct amphiphilic molecule;The compound can prepare nanomicelle assembly by film dispersion method, and simultaneously in macrocyclic cavity, anti-inflammatory drug can be loaded by host-guest interaction;The compound can realize drug release and nitric oxide absorption in anoxic environment, as a kind of cupped aromatic nanodrug system, in drug loading and nitric oxide absorption synergistic treatment anoxic related inflammation has important application value.

The application discloses a kind of high-performance hard carbon materials and preparation method and application in battery, belong to battery material technical field.The preparation method of the material includes the following steps: the biomass raw material is activated pretreatment, and activated biomass is obtained;After activated biomass is mixed with amphiphilic molecule control agent, composite precursor is obtained by hydrothermal reaction;In inert atmosphere, the multi-stage programmed temperature carbonization of composite precursor is carried out, and high-performance hard carbon material is obtained.The hard carbon material prepared by the application has a high proportion of sub-nanometer closed pores and expanded carbon layer spacing.When it is used as a negative electrode material in a battery, it can effectively promote the rapid deintercalation of sodium ions and guide the formation of thin and dense inorganic solid-state electrolyte film.Therefore, the material shows extremely high initial coulomb efficiency, excellent rate performance and super-long cycle life.

The present invention relates to: a sample precursor for crystal structure analysis, which contains a plurality of main molecules and a plurality of crystallization promoting molecules; a sample for crystal structure analysis, which is obtained by inclusion of a target molecule in the sample precursor for crystal structure analysis; a method for producing the sample for crystal structure analysis; and a kit for producing the sample for crystal structure analysis. The sample precursor for crystal structure analysis is capable of inclusion even if the molecule of the compound to be analyzed is a large molecule, a polar molecule, an amphiphilic molecule, or the like.

The invention discloses a high-performance hard carbon material, a preparation method thereof and application of the high-performance hard carbon material in a battery, and belongs to the technical field of battery materials. The preparation method of the material comprises the following steps: performing activation pretreatment on a biomass raw material to obtain activated biomass; mixing the activated biomass with an amphiphilic molecular regulating agent, and performing hydrothermal reaction to obtain a composite precursor; and carrying out multi-stage programmed heating carbonization on the composite precursor in an inert atmosphere to obtain the high-performance hard carbon material. The hard carbon material prepared by the invention has high-proportion sub-nanometer closed pores and enlarged carbon interlayer spacing. When the composite material is applied to a battery as a negative electrode material, rapid de-intercalation of sodium ions can be effectively promoted, and formation of a thin and compact inorganic solid electrolyte membrane is guided. Therefore, the material shows extremely high initial coulombic efficiency, excellent rate capability and ultra-long cycle life.

The invention belongs to the technical field of nano pharmacy, and particularly relates to a quercetin composite nano particle as well as a preparation method and application thereof. The quercetin composite nanoparticle comprises quercetin and an amphiphilic molecule, and the quercetin and the amphiphilic molecule are combined through an intermolecular force. In order to solve the problem that the bioavailability and the administration mode of quercetin are limited by the hydrophobic property of quercetin, the problem of toxic and side effects of a traditional solubilization technology (such as an organic solvent and a surfactant) is solved by preparing the stably dispersed quercetin composite nanoparticles, and a new path is provided for development of quercetin as a clinical candidate drug.

The invention relates to the field of magnetic resonance imaging. The invention relates to a nanovector comprising: - an external layer comprising a plurality of amphiphilic molecules, said amphiphilic molecules comprising at least one hydrophobic moiety linked to at least one hydrophilic moiety, and - a core comprising at least one organometallic complex having a paramagnetic property that can be activated by oxidation, said organometallic complex being functionalized by at least one hydrophobic moiety, the oxidation of the organometallic complex being controllable by light. The invention also relates to a method of magnetic resonance imaging.

The invention relates to an enamel bionic dental ceramic repair material for indirect repair as well as a preparation method and application of the enamel bionic dental ceramic repair material, firstly, an ultra-long hydroxyapatite nanowire is synthesized, or the ultra-long hydroxyapatite nanowire is subjected to silicon dioxide or silicon dioxide-zirconium oxide coating modification, and a nano-scale crystal structure form of enamel is simulated; secondly, coupling the nanowires by utilizing amphiphilic molecules gamma-methacryloxy propyl trimethoxy silane or 10-methacryloxy decyl phosphoric acid dihydrogen acid, and inducing the nanowires to be compactly and parallelly arranged, so as to form an enamel-like micron-sized glaze column structure. And then, immersing the nanowire aggregate with the glaze-column-like structure into resin monomer liquid, and realizing ordered and crossed macroscopic arrangement of the glaze-column-like structure under the action of centrifugal strong shearing force. Finally, excessive organic matrixes are removed, the material is compact and solidified under the high-pressure condition of cold sintering, efficient and large-scale enamel-like block construction is achieved, and the material is applied to indirect repair of oral clinical tooth defects.

The invention discloses a perovskite precursor solution, a perovskite thin film and application thereof, and belongs to the technical field of solar cells. The perovskite precursor solution comprises a perovskite structure substance raw material, a surfactant and a solvent, the perovskite structure substance raw material has an ABX3 structure, the surfactant is lysophosphatide amphiphilic molecules, and the use amount of the surfactant is 0.001%-20% of the molar weight of B-site ions in the perovskite structure substance raw material. According to the invention, the dual-functional surfactant is introduced into the perovskite precursor solution, so that a high-uniformity and high-density perovskite light absorption layer can be obtained on the substrate, and the photoelectric conversion efficiency of the perovskite solar cell is remarkably improved.