46 results about "Amphiphilic molecule" patented technology

The invention discloses a two-dimensional heterostructure silver-loaded mesoporous copper nanosheet catalyst, a preparation method thereof and application of the two-dimensional heterostructure silver-loaded mesoporous copper nanosheet catalyst in electro-catalytic synthesis of alanine, amphiphilic molecules N-(2-mercaptoethyl)-N, N-dimethyldocosyl-1-ammonium chloride are dissolved in water, then metal precursors silver nitrate and copper nitrate are added, stirring is carried out, and the two-dimensional heterostructure silver-loaded mesoporous copper nanosheet catalyst is obtained. Finally, hydrazine hydrate is added for step-by-step reduction, and the two-dimensional heterostructure silver-mesoporous copper nanosheet (Ag-meso-Cu) catalyst is obtained. The Ag-meso-Cu catalyst prepared by the method disclosed by the invention has an asymmetric two-dimensional mesoporous structure and shows enhanced electro-catalysis alanine synthesis performance, the Faraday efficiency of alanine synthesis is up to 89.84%, and the yield is up to 0.23 mmol h <-1 > mg <-1 >. The preparation of the two-dimensional heterostructure nanosheet with a multilevel structure is realized by utilizing a simple liquid phase method, and a new strategy is provided for electrochemical synthesis of amino acid under a mild condition.

The preparation method of the high-temperature-creep-resistant nano-composite pressure vessel steel comprises the following steps that a lead sulfide precursor is dissolved in an organic solvent, and heating reaction is conducted under the inert gas condition to generate lead sulfide quantum dots; mixing quantum dots with amphiphilic molecules, and performing ultrasonic emulsification to form a quantum dot colloidal solution; mixing the quantum dot colloidal solution with supercritical carbon dioxide to form a homogeneous fluid phase; the steel matrix is placed in a high-pressure reaction kettle, the homogeneous fluid phase is introduced, permeation is conducted for 2-4 h under the conditions that the pressure is 10-15 MPa and the temperature is 50-70 DEG C, and a steel billet is obtained; the steel billet is placed in hot isostatic pressing equipment, heat preservation and pressure maintaining are conducted for 1-2 h in the inert gas environment under the conditions that the pressure ranges from 150 MPa to 200 MPa and the temperature ranges from 800 DEG C to 900 DEG C, and then the steel billet is cooled to the room temperature; semiconductor quantum dots are introduced into a metal matrix, atomic-scale interface strengthening is achieved through the quantum effect and the supercritical fluid permeation technology, and the steady-state creep rate of the material at the temperature of 600 DEG C can be reduced to 1 / 10 of that of a traditional process by combining the microcosmic strengthening advantage of the quantum dots and the macroscopic permeation advantage of supercritical fluid.

The present application relates to the technical field of nanoprobes, and particularly relates to a near-infrared fluorescence / magnetic resonance dual-mode probe and a preparation method and application thereof. The present application adopts a Brij98 amphiphilic molecule to wrap an IR824Et-PhDTA-Gd near-infrared fluorescence / magnetic resonance dual-response molecule to prepare the probe, so that the probe has an absorption wavelength of 650-850 nm, generates a fluorescence signal under excitation of 785 nm laser, and the generated fluorescence wavelength can reach 1000 nm, which is in a near-infrared region (780-1700 nm); the probe has good positive magnetic resonance response characteristics, and a longitudinal relaxation rate (r1) of the probe is 28 mM ‑1 s ‑1 , which is 7 times of that of a clinically used Magnevist; the probe can be applied in the fields of fluorescence and / or magnetic resonance imaging, and has a wide application prospect. The preparation method of the near-infrared fluorescence / magnetic resonance dual-mode probe is simple in operation and low in cost.

The invention discloses a water-based photoresponse type rosin-based aggregation-induced emission amphiphilic molecule as well as a preparation method and application thereof. The molecular structural formula of the water-based light response type rosin-based AIE amphiphilic molecule is shown in the specification, or n ranges from 15 to 30. According to the water-based light-responsive rosin-based AIE amphiphilic molecule, a tetraphenyl ethylene or cyanostilbene fluorophore is introduced into the anhydride part of maleopimaric acid through an imidization reaction, and groups such as sodium carboxylate, amino acid sodium or polyethylene glycol are introduced into the carboxylic acid position to prepare the water-based light-responsive rosin-based AIE amphiphilic molecule. The solid of the molecule has blue fluorescence emission, and can be used for dyes or solid anti-counterfeiting materials. A photoresponsive AIE aqueous solution is prepared by using the amphiphilic molecule alone or compounding the amphiphilic molecule with dodecyl polyoxyethylene ether, and the photoresponsive AIE aqueous solution can be used for water-based anti-counterfeiting ink, cell imaging or 4-nitrophenol detection and the like.

The invention belongs to the field of fuel additive preparation, and relates to a preparation method of an alcohol-based oxygen-containing fuel additive. In order to solve the problems that an existing carbonic ester additive is relatively low in boiling point and is not matched with a diesel distillation range, the invention develops a special catalyst and a preparation process for preparing an alcohol-based oxygen-containing fuel additive, the catalyst takes a hierarchical pore molecular sieve as a carrier, and a potassium alcoholate active component and an amphiphilic molecule linking agent are introduced. Then catalyzing the ester exchange reaction of dimethyl carbonate and butanol by using the catalyst to generate a mixture of methyl butyl carbonate, dibutyl carbonate and the like, and fractionating to obtain the alcohol-based oxygen-containing fuel additive which has a proper boiling point and can be used for remarkably improving the oxygen content of the fuel.

The invention discloses a PD-L1 monoclonal antibody delivery system as well as a preparation method and application thereof, and belongs to the technical field of medicines. The preparation method comprises the following steps: coupling amino groups of BPA-PEG9 and a PD-L1 monoclonal antibody through NHS (N-hydroxysuccinimide) esterification to form BPA6-aPDL1; the preparation method comprises the following steps: grafting a glucose derivative maltomimetic acid MA of o-benzene dihydroxyl to a lipid-like amphiphilic molecule PEG (Polyethylene Glycol) (1.5 k-DSPE) through an amido bond to form MA4-PEG (1.5 k-DSPE), namely MA4-PD; then, the BPA6-aPDL1 reacts with the MA4-PD through a boric acid ester bond, and finally, the delivery system MB-aPDL1 is formed. The delivery system not only can successfully deliver the PD-L1 to a tumor site across a blood brain barrier, but also can accurately release the PD-L1 monoclonal antibody, so that the PD-L1 monoclonal antibody is only enriched in a tumor region, the residence time of the antibody is prolonged, the tumor anchoring capability of the antibody is improved, and the occurrence of immune-related adverse events is remarkably reduced.

A nanoparticle vaccine composition includes a shell including one or more amphiphilic molecules and one or more hapten molecules, where at least one amphiphilic molecule is conjugated to the hapten molecule, and a substantially hydrophobic core including an immunogenic protein, a vaccine adjuvant, one or more inert biocompatible materials, or a combination of two or more thereof, where the core is encapsulated in the shell to form a nanoparticle.

The application provides a paclitaxel molecular umbrella delivery system prodrug, a preparation method and application thereof. The paclitaxel molecular umbrella delivery system prodrug comprises a molecular umbrella target head part composed of two surface amphiphilic molecules connected by spermidine, a paclitaxel drug part, and a connecting group connecting the molecular umbrella target head part and the paclitaxel drug part through a disulfide bond; wherein the surface amphiphilic molecule is selected from cholic acid, deoxycholic acid or a sodium sulfonate thereof. Compared with paclitaxel, the paclitaxel molecular umbrella delivery system prodrug has significantly improved water solubility, lower toxicity to normal cells than free paclitaxel, and significantly improved safety; and the paclitaxel molecular umbrella delivery system prodrug has the following characteristics in a physiological environment: releasing active drugs in the high GSH / ROS microenvironment of tumor cells; and maintaining a prodrug state in normal cells.

The application relates to the field of mineral processing, and discloses a pyrrhotite collector, which comprises a mercaptan group collector, 5-30 parts, an amide group collector, 5-30 parts, a surfactant, 2-10 parts, an organic solvent, 20-50 parts, water, 20-60 parts, a collector aid, 1-15 parts, and a pH regulator, 1-10 parts. The pyrrhotite is efficiently collected by introducing the mercaptan group collector and the amide group collector into the collector. The collector molecules have high affinity with the active sites on the surface of the pyrrhotite, so that the collection efficiency of the mineral is greatly improved, and the technical purpose of significantly improving the ore recovery rate is achieved. Meanwhile, the amphiphilic molecules are used as the surfactant, including an anionic surfactant and a cationic surfactant. The surfactants can effectively adjust the properties of the mineral surface, and the selective separation of the pyrrhotite and other impurity minerals is realized.

The application belongs to the technical field of tumor treatment, and particularly relates to application of PBI-TPE-11 in preparation of a product for indicating drug resistance of tumor cells. The application aims to provide a new method for understanding drug resistance of tumor cells. The technical scheme of the application is that PBI-TPE-11 is applied in preparation of a product for indicating drug resistance of tumor cells. The application provides a substance PBI-TPE-11 which can be used for indicating drug resistance of tumor cells. The PBI-TPE-11 is an amphiphilic molecule which can self-assemble and aggregate in cells, and emit fluorescence under the action of excitation light; and can also be recognized by ABCG2 and transported to the outside of cells. Therefore, drug resistance of tumor cells can be indicated by observing and comparing signals and changes of cell fluorescence.

The application discloses a kind of polyethylene glycol cupped aromatic compounds and its preparation method and application, the polyethylene glycol cupped aromatic compound is connected by diazotization reaction by skeleton molecule and the diamino benzoic acid with metaposition protection, and then by upper end free carboxyl modification hydrophilic polyethylene glycol molecule to construct amphiphilic molecule;The compound can prepare nanomicelle assembly by film dispersion method, and simultaneously in macrocyclic cavity, anti-inflammatory drug can be loaded by host-guest interaction;The compound can realize drug release and nitric oxide absorption in anoxic environment, as a kind of cupped aromatic nanodrug system, in drug loading and nitric oxide absorption synergistic treatment anoxic related inflammation has important application value.

The application discloses a kind of high-performance hard carbon materials and preparation method and application in battery, belong to battery material technical field.The preparation method of the material includes the following steps: the biomass raw material is activated pretreatment, and activated biomass is obtained;After activated biomass is mixed with amphiphilic molecule control agent, composite precursor is obtained by hydrothermal reaction;In inert atmosphere, the multi-stage programmed temperature carbonization of composite precursor is carried out, and high-performance hard carbon material is obtained.The hard carbon material prepared by the application has a high proportion of sub-nanometer closed pores and expanded carbon layer spacing.When it is used as a negative electrode material in a battery, it can effectively promote the rapid deintercalation of sodium ions and guide the formation of thin and dense inorganic solid-state electrolyte film.Therefore, the material shows extremely high initial coulomb efficiency, excellent rate performance and super-long cycle life.

The invention discloses a high-performance hard carbon material, a preparation method thereof and application of the high-performance hard carbon material in a battery, and belongs to the technical field of battery materials. The preparation method of the material comprises the following steps: performing activation pretreatment on a biomass raw material to obtain activated biomass; mixing the activated biomass with an amphiphilic molecular regulating agent, and performing hydrothermal reaction to obtain a composite precursor; and carrying out multi-stage programmed heating carbonization on the composite precursor in an inert atmosphere to obtain the high-performance hard carbon material. The hard carbon material prepared by the invention has high-proportion sub-nanometer closed pores and enlarged carbon interlayer spacing. When the composite material is applied to a battery as a negative electrode material, rapid de-intercalation of sodium ions can be effectively promoted, and formation of a thin and compact inorganic solid electrolyte membrane is guided. Therefore, the material shows extremely high initial coulombic efficiency, excellent rate capability and ultra-long cycle life.

The invention relates to the field of magnetic resonance imaging. The invention relates to a nanovector comprising: - an external layer comprising a plurality of amphiphilic molecules, said amphiphilic molecules comprising at least one hydrophobic moiety linked to at least one hydrophilic moiety, and - a core comprising at least one organometallic complex having a paramagnetic property that can be activated by oxidation, said organometallic complex being functionalized by at least one hydrophobic moiety, the oxidation of the organometallic complex being controllable by light. The invention also relates to a method of magnetic resonance imaging.

The invention discloses a perovskite precursor solution, a perovskite thin film and application thereof, and belongs to the technical field of solar cells. The perovskite precursor solution comprises a perovskite structure substance raw material, a surfactant and a solvent, the perovskite structure substance raw material has an ABX3 structure, the surfactant is lysophosphatide amphiphilic molecules, and the use amount of the surfactant is 0.001%-20% of the molar weight of B-site ions in the perovskite structure substance raw material. According to the invention, the dual-functional surfactant is introduced into the perovskite precursor solution, so that a high-uniformity and high-density perovskite light absorption layer can be obtained on the substrate, and the photoelectric conversion efficiency of the perovskite solar cell is remarkably improved.

The invention discloses an electrolyte, a battery and a preparation method thereof, and relates to the technical field of batteries, the electrolyte comprises a basic solvent, an electrolyte salt, vinylene carbonate and an amphiphilic molecular additive; the structural formula of the amphiphilic molecular additive is R1-(CH2) n-R2. By adding the amphiphilic molecular additive into the electrolyte, the interfacial tension between the electrolyte and an electrode is remarkably reduced, the structural formula of the additive is R1-(CH2) n-R2, R1 is alkyl or aryl, the additive is endowed with hydrophobicity, and stable dispersion of the additive in the electrolyte is facilitated; r2 is carboxylate or sulfonate, hydrophilicity is provided, interaction between the electrolyte and the electrode is enhanced, due to the design, the electrolyte can permeate into a micropore structure of the electrode more easily, the solid-liquid interfacial tension is remarkably reduced, the contact angle of the electrolyte to the electrode is gradually reduced along with increase of the proportion of the additive, and the solid-liquid interfacial tension is remarkably reduced. Therefore, the wettability of the electrolyte on the electrode is obviously improved.

The invention discloses a preparation method of a non-fatty acid single-single-chain amphiphilic molecule vesicle, and relates to the technical field of vesicle preparation, the method realizes self-assembly of the vesicle through a dry-wet alternate dehydration rehydration process, and the method specifically comprises the following steps: dissolving non-fatty acid single-chain amphiphilic molecules in water to prepare a micelle aqueous solution, balancing at room temperature, and carrying out freeze drying to obtain the non-fatty acid single-chain amphiphilic molecule vesicle. Drying and dehydrating, then adding water with the same volume, and stirring through a glass rod, so as to spontaneously form vesicles; no cosurfactant, salt or organic solvent needs to be added in the whole preparation process, and the method is simple, low in cost, good in universality and suitable for anionic, cationic, zwitterionic and nonionic single-chain amphiphilic molecules. The obtained system is pure vesicles, is uniform in particle size, has good time stability, high-temperature stability and freeze-thaw stability, has coating capacity and biocompatibility, and can be widely applied to the fields of drug carriers, nanoparticle synthesis, cosmetics, biological membrane simulation and the like.

The application relates to a kind of fluoroboronic cyanine fluorescent probes and preparation method and application thereof, the fluorescent probe includes hydrophilic group and fluorescent dye connected by amide bond, can be obtained by adjusting the hydrophobicity of fluorescent dye fluoroboronic cyanine fluorescent probe of amphiphilic molecule or hydrophilic molecule, so that the fluorescent probe can be high signal-to-noise ratio, high specificity to cell membrane or mitochondria is fluorescently imaged;The fluoroboronic cyanine fluorescent probe provided by the application enriches the type of existing fluorescent probe, and the synthesis process is simple, the reaction condition is mild, and has the prospect of industrial production.

The invention provides an intermittent catheter comprising a hollow polymeric tubular body comprising a base polymer and a lubricious additive, wherein the lubricious additive comprises an amphiphilic molecule having a hydrophilic-lipophilic balance below 8.

The application discloses a kind of amphiphilic molecule modified graphene-based ion selective membrane and its preparation method and application.The application is sequentially poured into alkaline graphene oxide aqueous solution with the cationic surfactant aqueous solution containing N(CH3)2 + And the aqueous solution containing-COO ‑ Of polymer, after being mixed uniformly, membrane is extracted into film, the film is dried and annealed, and the amphiphilic molecule modified graphene-based ion selective membrane is obtained.In the application, due to the electrostatic interaction between the N(CH3)2 + Region of the polar head of dioctadecyldimethylammonium bromide and-COO ‑ Of sodium polyacrylate, the ion selective membrane shows good ion selective performance.The ion selective membrane exhibits stable power generation performance by the synergistic effect of dioctadecyldimethylammonium bromide, sodium polyacrylate and graphene oxide.

The invention relates to an extracellular vesicle in-situ microreactor and preparation and application thereof, the inner wall of a capillary is subjected to silanization treatment, and the surface of the capillary is modified with epoxy groups and amphoteric molecules through free radical polymerization reaction, so that a capillary open tubular column is prepared; and then modifying polyethyleneimine and iodoacetic acid N-hydroxysuccinimide ester in sequence through covalent bonding to prepare the amphoteric solid-phase alkylation capillary microreactor. The method has the advantages that the extracellular vesicles are captured in situ, the vesicle proteome sample is treated, and the method is suitable for proteome sample treatment of trace extracellular vesicle samples. In addition, the method is resistant to various surfactants and strong cracking reagents and has good sample compatibility.

The invention discloses a preparation method of nanoscale wall-broken selenium-enriched yeast, and relates to the technical field of food biologication.The preparation method comprises the following steps that selenium-enriched yeast suspension liquid is prepared; the selenium-enriched yeast suspension is subjected to mild local pore pretreatment, and local pores are formed in cell walls; a mixed solution containing amphiphilic molecules is added into the treated suspension liquid, a reaction is carried out under the low-strength shearing condition to form nanosheets, and the amphiphilic molecules comprise beta-cyclodextrin or a derivative thereof; and carrying out stabilizing treatment on the obtained product, and drying to obtain the nano-scale wall-broken selenium-enriched yeast. According to the invention, the nano-scale wall breaking with relatively ordered structure of the cell wall is realized, and the release and absorption efficiency of the selenium component in the gastrointestinal tract can be obviously improved; the wall breaking process is mild, low in temperature and low in shearing, the structural integrity and biological activity of selenium active ingredients are effectively protected, and the retention rate of the active ingredients is remarkably superior to that of a traditional violent wall breaking method.

This application relates to the field of traditional Chinese medicine preparation processing, and discloses a traditional Chinese medicine preparation for functional spleen and stomach regulation and its preparation method. The preparation is made from pomegranate concentrate, tangerine peel extract, ginger extract, yam extract, fructooligosaccharides, hawthorn extract, and purified water. The tangerine peel extract and ginger extract combine to form a homogeneous dispersion system, and the yam extract is coated with fructooligosaccharides. The preparation method involves: homogenizing tangerine peel, ginger, and a portion of the fructooligosaccharides under high pressure, then associating them with pomegranate concentrate under heat; separately, treating the yam extract and the remaining fructooligosaccharides with high shear to obtain a proteoglycan fluid; combining the two fluid phases; and adding hawthorn extract to adjust the pH of the system to 3.8 to 4.0. This invention, through the solubilizing effect of amphiphilic molecules, the steric barrier constructed by fructooligosaccharides, and a specific acidic electrostatic repulsion environment, blocks flavonoid precipitation and tannin-protein cross-linking reactions, significantly improving the physicochemical stability of the multi-component liquid preparation.

The present invention relates to a method for isolating an electrically charged analyte from a body sample, comprising: a) contacting the sample with solid particles coated with a molecule having an electric charge opposite to the electric charge of the analyte to allow the coating to capture the analyte by electrostatic interaction; b) separating the solid particles and the sample; and c) releasing the analyte from the solid particles by breaking down or destabilizing the coating. When the coating is a polymer it is broken down or destabilized by means of an enzyme. When the coating comprises a metal ion that is chelated to the surface of the solid particles, the coating is destabilized or broken down by means of a reducing agent. The coating can also be hydrophobic comprising an amphiphilic molecule embedded therein and then the breaking down or destabilizing the coating is achieved by means of a detergent or a competitive agent.

The invention discloses an amphiphilic molecule with diselenide bond linked nitroimidazole and polyethylene glycol and application of the amphiphilic molecule, and belongs to the technical field of medicine. The invention provides an amphiphilic molecule MNZ-Se2-PEG linked with nitroimidazole and polyethylene glycol through a diselenide bond. The structural formula of the amphiphilic molecule MNZ-Se2-PEG is as shown in (I). The amphiphilic molecules can entrap chemotherapeutic drugs through self-assembly to form a drug delivery system. The prepared drug delivery system has the advantages of being capable of keeping the structure stable under physiological conditions, releasing drugs through radiation responsiveness, enhancing sensitivity through radiotherapy and the like, and plays a role in radiotherapy and chemotherapy synergistic treatment. And the prepared drug delivery system has good biological safety. The invention provides a reliable carrier platform for realizing synergistic interaction of chemoradiotherapy, and has excellent development potential of a chemotherapy drug delivery system.

The invention relates to the technical field of water-based cleaning agents, in particular to a water-based cleaning agent and a preparation method and application thereof.According to the water-based cleaning agent, amphiphilic molecules are formed through chemical grafting of beta-cyclodextrin-PEO derivatives and siloxane and serve as core components, and a bio-based solubilizer and a corrosion inhibitor are supplemented; the preparation method comprises the following steps: firstly, preparing a cyclodextrin-PEO derivative through ring opening polymerization of ethylene oxide; then carrying out amidation reaction with amino siloxane to construct a grafted structure; according to the invention, a cyclodextrin cavity provides molecular recognition inclusion ability, a siloxane chain segment enhances interfacial permeability, and the cyclodextrin cavity and the siloxane chain segment cooperate with each other to realize efficient decontamination; the bio-based component ensures environmental friendliness, and practical application verifies that the cleaning agent is particularly suitable for precise cleaning in high-end fields such as semiconductor manufacturing and aerospace.

The application discloses a kind of composite nanoparticles for chemiluminescence excitation light power treatment and its preparation method and application.The composite nanoparticles include following three raw material components: chemiluminescence substrate, amphiphilic molecule and photosensitizer;The composite nanoparticles are chemiluminescence substrate and photosensitizer are co-encapsulated in the nanoparticle of amphiphilic molecule.The composite nanoparticles can respond to the overexpression of hydrogen peroxide in vivo, start chemiluminescence excitation photodynamic therapy, meanwhile, excited state photosensitizer can catalyze the oxidation of overexpressed NADH in tumor cell and generate H2O2 in situ, provide H2O2 source for chemiluminescence, promote the continuous performance of chemiluminescence.Therefore, the composite nanoparticles show efficient chemiluminescence excitation photodynamic activity to cancer cells, and have excellent therapeutic effect on subcutaneous tumor and lung metastasis tumor at the level of living body.

The invention provides compounds including a CpG oligodeoxynucleotide sequence linked to a lipid by a linker and related compositions and methods. The invention features a compound consisting of the nucleotide sequence of SEQ ID NO:1, at its 5′ end, bonded or linked by a linker to a lipid. Further, the invention features a method of treating a cancer in a human patient, comprising administering to the patient the compound. Further, the invention features a pharmaceutical composition including the compound and a pharmaceutically acceptable carrier. The invention features a kit including (I) the compound or a composition comprising the compound; and (ii) a protein comprising SEQ ID NO:2 or SEQ ID NO:3.

Novel nanogels comprising one or more bioactive molecules, therapeutic molecules or drugs and amphiphilic molecules and methods of making the same. Biomaterial implants, medical devices or bioprostheses coated with nanogels and methods of producing the same.