590 results about "Neutral ph" patented technology

An arthroplasty device is provided having an interpenetrating polymer network (IPN) hydrogel that is strain-hardened by swelling and adapted to be held in place in a joint by conforming to a bone geometry. The strain-hardened IPN hydrogel is based on two different networks: (1) a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups, and (2) a non-silicone network of ionizable monomers. The second network was polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. Within the IPN, the degree of chemical cross-linking in the second network is less than in the first network. An aqueous salt solution (neutral pH) is used to ionize and swell the second network. The swelling of the second network is constrained by the first network resulting in an increase in effective physical cross-links within the IPN.

Enteric coated stable oral pharmaceutical composition of acid unstable drug. The enteric coating is a bilayer with a pH gradient across its thickness comprising an inner layer of neutral or near neutral pH 7-7.5 and an outer layer of acidic pH 2-6. Also process for preparng the enteric coated stable oral pharmaceutical composition of acid unstable drug. The enteric coating is first carried out at neutral or near neutral pH of 7-7.5 to form an inner layer of neutral or near neutral pH and then at acidic pH of 2-6 to form an outer layer of acidic pH.

The invention discloses a preformed material for post-tensioned prestressing pipeline vacuum grouting or mudjacking and a preparation method thereof. The preformed material includes the following components by weight percent: 65 to 95 percent of silicate cement, 0.01 to 3 percent of high-range water-reducing agent, 0 to 1 percent of stabilizing agent, 0.05 to 5 percent of retarding agent, 1 to 20 percent of expanding agent, 0.2 to 2 percent of corrosion inhibitor, 0.01 to 1 percent of air entraining agent and 0 to 30 percent of mineral materials, wherein by uniformly and proportionally mixing the silicate cement, the high-range water-reducing agent, the stabilizing agent, the retarding agent, the expanding agent, the corrosion inhibitor, the air entraining agent and the mineral materials, the post-tensioned prestressing pipeline vacuum grouting or mudjacking preformed material can be obtained. After being uniformly mixed and stirred with water with neutral pH value according to the water cement ratio ranging from 0.24 to 0.32, the preformed material can be used, the obtained grouting material has the advantages of low water cement ratio, favorable flowability, no water bleeding and delamination, and favorable pumpability; meanwhile, the preparation method of the preformed material is simple and the raw material sources of the preformed material are wide.

Method for increasing the shelf-life of a pharmaceutical composition for parenteral administration comprising a glucagon-like peptide which is prepared from a peptide product that has been subjected to treatment at a pH above neutral pH.

The present invention provides antibodies and antigen-binding fragments thereof that specifically bind proprotein convertase subtilisin / kexin-9 (PCSK9) with greater affinity at neutral pH than at acidic pH. The antibodies of the invention may possess one or more amino acid changes as compared to antibodies that do not exhibit pH-dependent binding properties. For example, the present invention includes anti-PCSK9 antibodies which possess one or more histidine substitutions in one or more complementarity determining regions. The antibodies of the invention, with pH-dependent binding properties, remain in circulation and exhibit cholesterol lowering activity for prolonged periods of time in animal subjects as compared to anti-PCSK9 antibodies that do not exhibit pH-dependent binding properties. The antibodies of the invention are therefore useful for treating diseases and disorders related to elevated HDL cholesterol, wherein the antibodies of the invention can be administered to a patient at a lower dose and / or with less frequent dosing as compared to antibodies that do not exhibit pH-dependent binding properties.

A composite material comprising a mechanical mixture of aluminum oxide(s) and / or aluminum hydroxide(s) and aluminum (Al) metal, which when submerged in water, produces hydrogen gas at or near to neutral pH. The phenomenon has been demonstrated reproducibly. The evolution of hydrogen gas is dependent on several factors, namely, temperature, pH, proportion and particle size of ingredients and mixing conditions. The water split reaction proceeds for the mass ratio of Al to the oxide or hydroxide varying in the entire range up to the 99% of additive(s). The reaction proceeds in a pH range of water, 9>pH>4, and water temperature, from about 10° C. to 90° C.

The present invention provides: a modified FcRn-binding domain having an enhanced affinity for the Fc Receptor neonatal (FcRn) at neutral pH; an antigen-binding molecule comprising said FcRn-binding domain, which has low immunogenicity, high stability and form only a few aggregates; a modified antigen-binding molecule having an increased FcRn-binding activity at neutral or acidic pH without an increased binding activity at neutral pH for a pre-existing anti-drug antibody; use of the antigen-binding molecules for improving antigen-binding molecule-mediated antigen uptake into cells; use of the antigen-binding molecules for reducing the plasma concentration of a specific antigen; use of the modified FcRn-binding domain for increasing the total number of antigens to which a single antigen-binding molecule can bind before its degradation; use of the modified FcRn-binding domain for improving pharmacokinetics of an antigen-binding molecule; methods for decreasing the binding activity for a pre-existing anti-drug antibody; and methods for producing said antigen-binding molecules.

The present invention relates to a chemical compound that has applications as a luminescent indicator dye, and to an optical sensor, typically employed for determination of near-neutral pH values of aqueous samples. The optical sensor has particular application in the pH determination of body liquids such as, for example, blood, plasma and serum.

The present invention generally relates to treatment of iron-related conditions with iron carbohydrate complexes. One aspect of the invention is a method of treatment of iron-related conditions with a single unit dosage of at least about 0.6 grams of elemental iron via an iron carbohydrate complex. The method generally employs iron carbohydrate complexes with nearly neutral pH, physiological osmolarity, and stable and non-immunogenic carbohydrate components so as to rapidly administer high single unit doses of iron intravenously to patients in need thereof.

A polymer matrix that may coated on an electrode is created by co-crosslinking (1) an adduct of a polyaniline formed by templated oxidative polymerization on a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme. The polymer matrix may be hydrated, and the absorbed water may make it permeable to, for example, glucose. The polyaniline may be polyaniline itself or a substituted polyaniline; the water-soluble crosslinker may be poly(ethylene glycol) diglycidyl ether, and the redox enzyme may be glucose oxidase. The polymer matrix may be produced by co-crosslinking (1) an adduct of an electrically conductive polymer and a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme in a single step at an about neutral pH, curing by drying. After hydration, the crosslinked polymer matrix may form a 3-dimensional glucose-permeable bioelectrocatalyst, catalyzing the electrooxidation of glucose.

The invention provides container systems, kits and methods for peritoneal dialysis (PD) solutions. Such a system, for example, includes a first compartment that contains a Pt) osmotic agent and a second compartment that contains a PD buffer agent. The compartments maintain their respective contents separately from one another for purposes of transport, storage and / or sterilization. However, the compartments are fluidly couplable, so that their respective contents can be combined with one another, e.g., following sterilization of the agents and prior to their introduction into the patient's abdomen.

A composition comprising crosslinked expandable polymeric microparticles capable of hydrolysis at or below neutral pH and a method of modifying the permeability to water of a subterranean formation by introducing such compositions into the subterranean formation is disclosed and claimed. This invention further relates to compositions and methods for the recovery of hydrocarbon fluids from a subterranean reservoir or formation subjected to CO2 or CO2 Water Alternating Gas flooding at low pH and increases the mobilization and / or recovery rate of hydrocarbon fluids present in the subterranean formations.

The present invention provides a method of increasing protein production in a cell culture by growing cells that produce the protein (e.g., the growth phase) in a perfusion cell culture to a high cell density (i.e., at least above about 40×106 cells / N mL) and then switching to a protein production phase, wherein the cells are cultured in a fed-batch cell culture. The present invention further provides a method for clarifying a protein from a cell culture by adjusting the pH of the cell culture to below neutral pH (i.e., below a pH of 7) and settling the cell culture, such that the cell culture separates to form a supernatant layer and a cell-bed layer, wherein the protein is in the supernatant layer.

The present invention relates to insulin derivatives having a side chain attached either to the -amino group of the N-terminal amino acid residue of the B chain or to the amino group of a Lys residue present in the B chain of the parent insulin via an amide bond which side chain comprises at least one aromatic group; at least one free carboxylic acid group or a group which is negatively charged at neutral pH, a fatty acid moiety with 4 to 22 carbon atoms in the carbon chain; and possible linkers which link the individual components in the side chain together via amide bonds.

The invention provides methods for culturing yeast at a neutral pH level. Yeast cultured under neutral pH conditions exhibit desirable characteristics useful for biological purposes, such as the development of vaccines, prophylactics and therapeutics. The invention also provides for compositions and kits comprising yeast grown using the methodologies disclosed herein.

The invention discloses a high fluidity grouting material and a production method thereof. The high fluidity grouting material comprises the following components in percentage by weight: on the basis of 100 percent of total amount, 60 to 96 percent of conventional portland cement, 1 to 20 percent of calcite powder, 1 to 20 percent of a mineral modifying component, and 2 to 18 percent of swelling agent, wherein measuring on the basis of using the total amount of four substances as base number, 0.01 to 4 weight percent of high efficiency slushing agent and 0.0005 to 1 weight percent of plasticity swelling agent are added in the mixture of the four substances. The high fluidity grouting material can be made of raw materials mixed by adopting a dual-shaft paddle non-gravity high-efficiency mixer. The material has simple industrialized production process and stable product quality, adopts the water-cement ratio of between 0.24 and 0.28, is evenly blended by water with neutral pH value, and has the advantages of high fluidity, no bleeding, no segregation or layering, slight swelling, easy pump delivery, good durability and the like after the material is uniformly mixed by water.

Method for increasing the shelf-life of a pharmaceutical composition comprising a glucagon-like peptide which is prepared from a peptide product that has been dried at a pH above neutral pH.

A free-flowing, hydrophobic starch composition has a near-neutral dry product pH. Methods for making the hydrophobic starch composition by preparing an aqueous mixture comprising a starch, a siliconate, and an acid, where the aqueous mixture has a near-neutral pH, and drying the starch solids to obtain a hydrophobic starch. Novel fuel compositions comprise hydrophobic starch which can be used in internal combustion engines, such as diesel engines. Hydrophobic starch compositions may be used as fuels or fuel components. Novel methods of fueling and operating internal combustion engines use hydrophobic starch as fuel or fuel components.

This invention relates to a method and apparatus for using ozone to disinfect, decontaminate and deodorize animal manure. The invention contemplates injecting ozone gas into manure, while the manure is rotated on an auger in a sealed chamber. As a result of the invention, the manure is disinfected, decontaminated, and deodorized, while nutrients in the manure and a neutral pH are maintained.

Contemplated devices and methods include an electrolytic cell having a cathode and a carbon felt anode, wherein the carbon felt anode is configured as a flow-through anode for an aqueous solution in which a contaminant is dissolved or dispersed. The cell is operated at a current density that promotes formation of oxidizing species in neutral pH to thus destroy the contaminant and at a flow rate sufficient to prevent oxidative damage of the carbon felt.

The present invention generally relates to treatment of iron-related conditions with iron carbohydrate complexes. One aspect of the invention is a method of treatment of iron-related conditions with a single unit dosage of at least about 0.6 grams of elemental iron via an iron carbohydrate complex. The method generally employs iron carbohydrate complexes with nearly neutral pH, physiological osmolarity, and stable and non-immunogenic carbohydrate components so as to rapidly administer high single unit doses of iron intravenously to patients in need thereof.

The invention disclosed herein provides, Porous Crystalline Frameworks (PCFs) also known as Covalent Organic Frameworks (COFs) that exhibit stability towards acidic, basic and neutral pH conditions. Further the invention discloses economical, environmentally-friendly process for the synthesis thereof.

The invention discloses a method which adopts hydrothermal compound method for preparing flower-shaped microsphere of molybdenum disulfide. The invention comprises the steps: Na2MoO4, CS (NH2)2 and inorganic additives are added to a reactor and deionized water of 60 percent of the reactor column is also added and then the reactor is sealed and kept in a constant temperature case with a temperature ranging from 150 DEG C to 250 DEG C at least for 12 hours to be cooled in ambient temperature; obtained objects are washed by deionized water eccentrically to a neutral pH value; the flower-shaped microsphere of molybdenum disulfide is obtained after the objects are dried. The method of the invention has simple technique, easy operation, low cost and the products prepared has high purity and is promising for large-scaled production.

The invention provides a method for preparing a silver / graphene antimicrobial composite material, and the method provided by the invention comprises the following steps: a) providing a reductive graphene oxide-sodium polystyrene sulfate composite solution; b) heating the composite solution obtained in the step a) to 50-70 DEG C; and c) adding a silver nitrate solution into the heated composited solution obtained in the step b) for reaction, thus obtaining the silver / graphene antimicrobial composite material. The invention provides the method for preparing the silver / graphene antimicrobial composite material; and in the method, a reductive graphene oxide tablet is taken as a reducing agent for carrying out reduction on silver ions under a neutral pH condition so as to generate silver nano particles. In the method provided by the invention, no sodium borohydride is taken as a reducing agent, and in the whole preparation process, no potassium hydroxide is adopted, therefore, when the composite material prepared by the method is subjected to later application, no large biological irritant is caused. In addition, antibacterial experiments show that the silver / graphene antimicrobial composite material provided by the invention has a better antibacterial effect.

A non-porous Zn2+ conducting inorganic lamellar layer is formed on the zinc coating of galvanized steel or on a zinc anode of an electrochemical cell. The layer reduces the rate of the unwanted chemical reaction of zinc and oxygen but allows desired electrochemical reactions underlying the cathodic protection of the steel and the efficient utilization of zinc anodes in electrochemical cells, e.g., a physiological buffer solution or serum as their electrolytes. The ion conducting non-porous lamellar layer having a hopeite phase Zn3(PO4)2.4H2O may be formed spontaneously on, e.g., NAFION® coated zinc anodes discharged in neutral pH saline phosphate solutions.

The invention discloses a transparent conductive film and a preparation method thereof. The transparent conductive film covers a transparent substrate and is a blend system of metal nano-wires and conducting polymer or is a combination layer of a metal nano-wire layer and a conducting polymer layer from bottom to top sequentially. The metal nano-wires include gold, silver, copper and nickel nano-wires; the conducting polymer refers to poly (3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) with neutral pH value. Conducting uniformity of the metal nano-wire film is improved, and the transparent conductive film has high stability when being stored, heated and applied with current in a water-oxygen environment.

The present invention is directed to a multi-surface cleaning composition having an anti-bacterial ingredient for cleaning furniture surfaces. The anti-bacterial cleaning component includes a quaternary ammonium chloride compound or combinations thereof. The composition further includes a pH adjuster to provide for a generally neutral pH in the range of about 6 to about 9 including a combination of components, preferably white distilled vinegar and an amine compound. The cleaning composition provides for good cleaning and disinfecting of wood surfaces and other furniture surfaces without leaving streaks.

An objective of the invention is to provide anti-C5 antibodies and methods of using the same. The invention provides anti-C5 antibodies and methods of using the same. In some embodiments, an isolated anti-C5 antibody of the present invention binds to an epitope within the β chain of C5 with a higher affinity at neutral pH than at acidic pH. The invention also provides isolated nucleic acids encoding an anti-C5 antibody of the present invention. The invention also provides host cells comprising a nucleic acid of the present invention. The invention also provides a method of producing an antibody comprising culturing a host cell of the present invention so that the antibody is produced. The invention further provides a method of producing an anti-C5 antibody comprising immunizing an animal against a polypeptide which comprises the MG1-MG2 domain of the β chain of C5. Anti-C5 antibodies of the present invention may be for use as a medicament. Anti-C5 antibodies of the present invention may be for use in treating a complement-mediated disease or condition which involves excessive or uncontrolled activation of C5. Anti-C5 antibodies of the present invention may be for use in enhancing the clearance of C5 from plasma.