Hydrogel arthroplasty device

a technology of arthroplasty and hydrogel, which is applied in the direction of femoral heads, prostheses, ligaments, etc., to achieve the effect of stimulating bone cell growth and/or adhesion

Inactive Publication Date: 2009-04-02
THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPT OF VETERANS AFFAIRS +1
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Benefits of technology

[0017]In still another example, the coefficient of friction of the bearing region of the strain-hardened interpenetrating polymer network hydrogel in an aqueous solution is less than 0.2. In still another example, one side of the device is modified with another polymeric material, other functional groups, or biomolecules

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However, if only one of the surfaces is damaged, then only one

Method used

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[0093]The following description refers to an exemplary embodiment of a strain-hardened interpenetrating polymer network hydrogel with PEG as a first network 10 polymer and PAA as a second network 11 polymer. The IPN hydrogel is synthesized by a (two-step) sequential network formation technique based on UV initiated free radical polymerization. A precursor solution for the first network is made of purified, telechelic PEG dissolved at a typical concentration of 50% w / v in phosphate buffered saline (PBS) solution, water, or an organic solvent with either 2-hydroxy-2-methyl-propiophenone or 2-hydroxy-1-[4-(2-hydroxyethoxy)phenyl]-2-methyl-1-propanone as the UV sensitive free radical initiator. The types of telechelic PEG macromonomers used were PEG-diacrylate, PEG-dimethacrylate, PEG-diacrylamide, and PEG-diallyl ether. In other embodiments, either network can be synthesized by free radical polymerization initiated by other means, such as thermal-initiation and other chemistries not in...

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Abstract

An arthroplasty device is provided having an interpenetrating polymer network (IPN) hydrogel that is strain-hardened by swelling and adapted to be held in place in a joint by conforming to a bone geometry. The strain-hardened IPN hydrogel is based on two different networks: (1) a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups, and (2) a non-silicone network of ionizable monomers. The second network was polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. Within the IPN, the degree of chemical cross-linking in the second network is less than in the first network. An aqueous salt solution (neutral pH) is used to ionize and swell the second network. The swelling of the second network is constrained by the first network resulting in an increase in effective physical cross-links within the IPN.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority from U.S. Provisional Patent Application 60 / 923,988 filed Apr. 17, 2007, which is incorporated herein by reference. This application is a continuation-in part of U.S. patent application Ser. No. 12 / 070,336, filed Feb. 15, 2008, which is incorporated herein by reference.FIELD OF THE INVENTION[0002]The present invention relates generally to interpenetrating polymer network hydrogels. More particularly, the present invention relates to devices and materials useful for orthopaedic prostheses.BACKGROUND OF THE INVENTION[0003]With disease or damage, the normally smooth, lubricious cartilage covering joint surfaces progressively deteriorates, exposing bone and leading to arthritic pain that is exacerbated by activity and relieved by rest. Today, patients with osteoarthritis are faced with only one of two choices: either manage their pain medically, or undergo an effective but highly bone-sacrificing surgery. Medi...

Claims

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Application Information

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IPC IPC(8): A61F2/08
CPCA61F2/30756A61L2430/24A61F2/3603A61F2/3872A61F2/4202A61F2/4225A61F2/4241A61F2/4405A61F2002/30075A61F2002/30448A61F2002/30754A61F2002/3619A61F2210/0061A61F2220/005A61F2310/00293A61L27/3843A61L27/52A61F2/34A61F2002/30593A61F2/36A61L27/18A61L27/34A61L27/50
Inventor MYUNG, DAVIDKOURTIS, LAMPROSHARTMANN, LAURAFRANK, CURTIS W.GOODMAN, STUART B.CARTER, DENNIS R.
Owner THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPT OF VETERANS AFFAIRS
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