16232results about How to "Good chemical stability" patented technology

The present invention provides solid pharmaceutical compositions for improved delivery of a wide variety of pharmaceutical active ingredients contained therein or separately administered. In one embodiment, the solid pharmaceutical composition includes a solid carrier, the solid carrier including a substrate and an encapsulation coat on the substrate. The encapsulation coat can include different combinations of pharmaceutical active ingredients, hydrophilic surfactant, lipophilic surfactants and triglycerides. In another embodiment, the solid pharmaceutical composition includes a solid carrier, the solid carrier being formed of different combinations of pharmaceutical active ingredients, hydrophilic surfactants, lipophilic surfactants and triglycerides. The compositions of the present invention can be used for improved delivery of hydrophilic or hydrophobic pharmaceutical active ingredients, such as drugs, nutritional agents, cosmeceuticals and diagnostic agents.

Disclosed are improved polymer materials. Also disclosed are fine fiber materials that can be made from the improved polymeric materials in the form of microfiber and nanofiber structures. The microfiber and nanofiber structures can be used in a variety of useful applications including the formation of filter materials.

The present invention provides means to improve the chemical stability of aqueous, parenteral pharmaceutical compositions comprising a polypeptide and glycerin. Reactive aldehydes are identified in commercial glycerins, and means for reducing such are provided. Convenient means are provided to assay for reactive aldehydes in glycerin, and a strong linear correlation between the level of reactive aldehydes in glycerin and chemical stability of compositions comprising a polypeptide and glycerin is demonstrated. The invention includes aqueous compositions comprising a polypeptide and glycerin having improved chemical stability compared to compositions previously known.

The present invention relates to methods, kits, combinations, and compositions for treating, preventing or reducing the risk of developing a testosterone-deficient disorder, or the symptoms associated with, or related to a testosterone-deficient disorder in a subject in need thereof. The present invention also relates to a method of administering a steroid in the testosterone synthetic pathway to a subject in need thereof.

Described are pharmaceutical compositions comprising at least one steroidal drug such as a progestin (e.g. drospirenone, progesterone, eplerenone, etonogestrel) and/or an estrogen (estradiol and esters thereof) in molecularly dispersed form. The composition comprises a steroidal drug, preferably drospirenone, which is present in the composition in a non-particulate form. Preferably, the drug is present in a dissolved state in the excipient. The molecularly dispersed drug will be released very fast as dissolution takes place instantly when the dosage unit has disintegrated. Also described are methods for preparing the pharmaceutical compositions and methods of using the compositions.

Novel chromatographic materials for chromatographic separations, columns, kits, and methods for preparation and separations with a superficially porous material comprising a substantially nonporous core and one or more layers of a porous shell material surrounding the core. The material of the invention is comprised of superficially porous particles and a narrow particle size distrution. The material of the invention is comprised of a superficially porous monolith, the substantially nonporous core material is silica; silica coated with an inorganic/organic hybrid surrounding material; a magnetic core material; a magnetic core material coated with silica; a high thermal conductivity core material; a high thermal conductivity core material coated with silica; a composite material; an inorganic/organic hybrid surrounding material; a composite material coated with silica; a magnetic core material coated with an inorganic/organic hybrid surrounding material; or a high thermal conductivity core material coated with an inorganic/organic hybrid surrounding material.

A pharmaceutical delivery system for oral inhalation is disclosed through nebulization consisting of an inert supporting material impregnated with or deposited with pharmaceutically active ingredient which must be solubilized or suspended in a pharmaceutical solvent to form a solution or suspension prior to administration. Each pharmaceutical delivery unit dosage form comprises one or more therapeutically effective and safe amounts of pharmaceutically active ingredient uniformly impregnated in or deposited on a supporting material which is a natural or synthetic polymer, woven or non-woven fabrics, inert paper, inorganic materials such as foil and combination thereof in a single or multi-layer lamination in a form of a sheet or strip or film or membrane or sponge-like or cup or well. The dosage form of this invention is to be administered to a patient through oral or nasal inhalation using a nebulizer after reconstitution with a reconstituting solvent.

The invention relates to a light solidifying high-abrasion resistant fingerprint resistant coating which is used for the surfaces of plastic shells of portable electronic products, such as mobile phones, MP3, digital cameras, handheld computers, and the like and comprises the following components: 10-35 percent of high-functionality urethane acrylate, 5-25 percent of bifunctional urethane acrylate, 0.01-20 percent of acrylic ester monomer, 5-20 percent of high-functionality acrylic ester, 5-40 percent of fluorin-contained acrylic ester, 0.01-10 percent of nano inorganic powder filler, 1-5 percent of light initiating agent, 0.01-5 percent of auxiliary agent and 5-30 percent of solvent. The invention improves the fingerprint resistant capability of a coating film by the enrichment and microphase separation of a fluorin-contained group added into the coating on the surface of a coating surface, provides excellent abrasion resistance and hardness by using the polyurethane structure in the coating and the added nano abrasion resistant filler and meets the requirements of abrasion resistance, scratch resistance and fingerprint resistance of the portable electronic products.

The present invention is a gas component sensor comprising novel electrolyte compositions. The electrolyte compositions in bulk, sintered or thin film embodiments are capable of forming with different-metal sensing and reference electrodes a highly stable gas oxide sensors. The novel electrolyte composition changes electrochemical reactions at the sensing and reference electrodes and the overall reaction of the electrodes and electrolyte. The novel electrolyte compositions have: (1) excellent chemical stability and thermal compatibility as to the electrodes and a preferred ceramic substrate, (2) excellent chemical stability with the environment as to the reference and sensing electrodes, which need not be sealed against the atmosphere to be sensed, (3) effective adherence to the substrate and electrode metals.

The present invention relates to the delivery of drug amines through an inhalation route. Specifically, it relates to aerosols containing drug amines that are used in inhalation therapy. In one aspect of the present invention, a method of delivering an amine drug in an aerosol form is provided. The method comprises: a) heating a coating, which includes an amine drug salt on a substrate contained in a device to a temperature sufficient to volatilize the amine drug from the coating, b) by said heating, forming an amine drug vapor, and c) during said heating, drawing air through said device, condensing said vapor to form aerosol particles containing less than 10% degradation products of the compound.

The invention discloses lithium-enriched anti-perovskite sulfides and a solid electrolyte material. The general formula of the lithium-enriched anti-perovskite sulfides is (LimMn)3-xS1-y(XaYb)1-z, wherein m is more than 0 and less than or equal to 1, n is more than or equal to 0 and less than to 0.5, (m+n) is less than or equal to 1, a is more than 0 and less than or equal to 1, b is more than or equal to 0 and less than 1, (a+b) is less than or equal to 1, x is more than or equal to 0 and less than or equal to 0.5, y is more than or equal to 0 and less than or equal to 0.5, z is more than or equal to 0 and less than or equal to 0.5 and x=2y+z; M is H, Na, K, Rb, Mg, Ca, Sr, Ba, Y, La, Ti, Zr, Zn, B, Al, Ga, In, C, Si, Ge, P, S or Se; and X is Fe, Cl, Br or I, and Y is a negative ion. The solid electrolyte material has high ion conductivity and thermal stability and a wide working temperature range, and can be applied to lithium ion batteries, rechargeable metal lithium batteries, lithium liquid flow batteries or lithium ion capacitors.

An anode material capable of obtaining a high capacity and superior charge-discharge efficiency, and an anode and a battery using the anode material are provided. An anode includes an anode material including an active portion including at least one of silicon and tin as an element and a coating portion of a metal oxide arranged on a part of a surface of the active portion. The ratio of the coating portion to the active portion is within a range from 0.01 wt % to 10 wt % inclusive. Thereby, a high capacity and superior charge-discharge efficiency can be obtained.

Pharmaceutical compositions comprised of low-solubility and/or acid-sensitive drugs and neutralized acidic polymers are disclosed.

The invention discloses a nanometer high temperature resistant thermal insulation and prevention coating. SiO2 aerogel, modified potassium hexatitanate whisker, aluminum silicate fiber, ultra-fine cenosphere, nanometer TiO2 and nanometer Al2O3 are used as a thermal insulation filler. A vacuum thermal insulation layer is formed by nano porous structures of SiO2 aerogel and cenosphere. The aluminum silicate fiber is used as a reinforcing and toughening material. The infrared shading performance of potassium hexatitanate whisker, nanometer TiO2 and nanometer Al2O3 are used as a thermal radiation shielding layer. A silicon resin emulsion and an acrylic emulsion are compounded to be an adhesive. Therefore, the nanometer 600 DEG C temperature resistant thermal insulation and prevention coating is prepared with matching of a variety of functional additives. The nanometer high temperature resistant thermal insulation and prevention coating has the characteristics of scumbling, thermal insulation, waterproofing, anti-crack, anti-corrosion, high temperature resistance, weather-proofing, durability and the like and is applicable to the field of industrial high temperature resistant thermal insulation energy conservation.

A membrane electrode assembly for a polymer electrolyte fuel cell characterized by using, as solid polyelecrolyte of at least one of a membrane and a catalyst binder, a fluorinated sulfonic acid polymer with a monomer unit represented by the following general formula (3):

(wherein Rf¹ is a bivalent perfluoro-hydrocarbon group having a carbon number of from 4 to 10), wherein said fluorinated sulfonic acid polymer has melt flow rate (MFR) not higher than 100 g/10 min at 270° C. when a —SO₃H group in said polymer is converted to —SO₂F.

The present invention relates to development of efficacious pharmaceutical compositions comprising an anti-angiogenic compound in a therapeutically effective amount complexed with or encapsulated in a cyclodextrin derivative.

The invention relates to a manufacturing method of environment-friendly aluminum paste for a silicon solar battery back electric field. The aluminum paste comprises the following components and contents (weight percentage): 50 to 80 percent of aluminum conducting powder, 1 to 10 percent of crown glass binding agent, 0.05 to 5 percent of trivalent metal organic compound, 2 to 15 percent of organic resin, 10 to 25 percent of solvent and 2 to 10 percent of additive. The manufacturing method of the environment-friendly aluminum paste comprises the preparation of a glass binding agent, the preparation of an organic carrier, the formulation of aluminum paste stock and the processing technique of paste stock. The paste stock researched by the invention can not increase or generate substances which are harmful to human bodies and pollute the environment during the production and processing; the lead content of the paste stock is less than 100 ppm; and the contents of other hazardous substances such as Hg, Cd and the like can satisfy the environmental protection requirements. The aluminum past is applied to electrodes in the silicon solar battery back electric field; and the aluminum past has strong adhesion, good ohmic contact, and high conversion efficiency of a battery through the quick heat treatment in a continuous tunnel furnace.

In one aspect, pharmaceutical compositions comprising dispersions of an acid-sensitive drug and a neutral dispersion polymer are disclosed. The acid-sensitive drug has improved chemical stability relative to dispersions of the drug and acidic polymers. In another aspect, pharmaceutical compositions of low-solubility drugs and amphiphilic, hydroxy-functional vinyl copolymers are disclosed.

The present invention is for high performance UV-cross-linked membranes from polymers of intrinsic microporosity (PIMs) and the use of such membranes for separations. More specifically, the invention involves the methods of making UV-cross-linked membranes from PIMs. These membranes were prepared by cross-linking the UV-cross-linkable membranes from PIMs by exposure to UV-radiation. Pure gas permeation test results demonstrate that the UV-cross-linked membranes from PIMs exhibit CO₂/CH₄ performance well above the Robeson's polymer upper bound trade-off curve for CO₂/CH₄ separation. They have more than doubled selectivity for CO₂/CH₄ and extremely high permeability of CO₂ compared to the original UV-cross-linkable membranes from PIMs. These membranes also show excellent separation performance for CO₂/N₂, H₂/CH₄, O₂/N₂, and propylene/propane separations. These high performance UV-cross-linked membranes are very useful for gas and liquid separations such as CO₂/CH₄, CO₂/N₂, H₂/CH₄, O₂/N₂, olefin/paraffin, deep desulfurization of gasoline and diesel fuels, and ethanol/water separations.

The present invention provides porous mineral oxide beads which have large pore volumes and enhanced stability. The beads are based on a tetravalent metal oxide, such as zirconia, titania or hafnia. These highly porous beads are produced from a mixture of tetravalent mineral oxides, mineral pore inducing agents which are oxides or salts of trivalent metals, and optional binders. The porous mineral beads can be filled with a polymer gel and used for adsorption and chromatography applications.

A non-aqueous electrolyte secondary battery including a positive electrode, a negative electrode, a separator interposed between the positive and negative electrodes, and a non-aqueous electrolyte. The negative electrode includes composite particles and a binder. Each of the composite particles includes: a negative electrode active material including an element capable of being alloyed with lithium; carbon nanofibers that are grown from a surface of the negative electrode active material; and a catalyst element for promoting the growth of the carbon nanofibers. The binder comprises at least one polymer selected from the group consisting of polyimide, polyamide imide, polyamide, aramid, polyarylate, polyether ether ketone, polyether imide, polyether sulfone, polysulfone, polyphenylene sulfide, and polytetrafluoroethylene.