68results about How to "Improve physical stability" patented technology

The invention relates to a crystal form of a compound I, a preparation method of the crystal form, and application of the crystal form in preparation of iron deficiency related treatment medicines for treating anemia accompanied with or not accompanied with iron deficiency. The novel crystal form of the compound I provided by the invention has the advantages of high solubility, good chemical stability, solid stability, mechanical stability and humidity stability, simple preparation method, easiness in crystal form control, low production amplification cost and the like, and has important value for development of the medicine in the future. # imgabs0 #

This invention relates to the field of pesticide technology, specifically to a fungicidal composition, its preparation method, and its uses. The invention provides a fungicidal composition comprising an active ingredient, a first functional component, a second functional component, and an adjuvant; the active ingredient comprises fluthiazopyrone and cyazofamid; the first functional component comprises at least one selected from silica, titanium dioxide, and zinc oxide; the second functional component comprises at least one selected from citric acid, acetic acid, benzoic acid, urea, and triethanolamine. By introducing specific first and second functional components, this invention synergistically works with the active ingredient, effectively overcoming the key defects of fluthiazopyrone's easy photodegradation and cyazofamid's easy hydrolysis, thus improving the stability of the compound formulation; while ensuring the excellent control efficacy and resistance management advantages of both against oomycete diseases such as grape downy mildew, it extends the duration of action and weather resistance of the agent, providing a more stable, efficient, and long-lasting solution for field application.

The invention relates to the technical field of concrete, and particularly discloses durable concrete, a concrete pole and a preparation method of the concrete pole. Wherein the durable concrete comprises cement, fly ash, mineral powder, sand, gravel, metal aggregate, polyurethane aqueous dispersion, an antirust agent, a water reducing agent, an air entraining agent and water; wherein the metal aggregate is formed by compounding steel ladle slag and iron tailing sand, and the weight ratio of the steel ladle slag to the iron tailing sand is (0.6-0.8): 1. The polyurethane aqueous dispersion forms a continuous polymer film between the hydration product and the metal aggregate, so that the performance of an interface transition area between the metal aggregate and cement, mineral powder, fly ash and other cementing materials is improved, the durability of the concrete is improved, and the service life of an electric pole made of the concrete can be prolonged.

The invention relates to the technical field of carbon dioxide dealkylation, and discloses a catalyst for removing hydrocarbon impurities in carbon dioxide and a preparation method of the catalyst. According to the catalyst for removing hydrocarbon impurities from carbon dioxide, active components are loaded on composite carrier particles; the composite carrier particles are obtained by loading a catalytic promoter cerium oxide on composite aerogel, grinding and sieving; the composite aerogel is prepared from a coagulant aid and at least two aerogel precursors by a sol-gel method. The preparation method of the catalyst for removing hydrocarbon impurities in carbon dioxide comprises the following preparation steps: 1) preparing composite aerogel from an aerogel precursor and a coagulant aid through a sol-gel method; 2) soaking the composite aerogel in a cerium nitrate solution, naturally airing, drying, roasting, grinding and sieving to obtain composite carrier particles; and 3) dipping the composite carrier particles in a mixed solution of active components, standing, drying and roasting to obtain the catalyst for removing hydrocarbon impurities from carbon dioxide.

This invention belongs to the field of QR code printing control technology, specifically disclosing a variable QR code printing control method. This method includes: importing order parameters containing QR code printing position, content type, and application scenario characteristics; real-time acquisition of the flatness and colorimetric features of the substrate surface; quantifying and generating integrity assurance coefficient and clarity maintenance coefficient based on flatness features and printing position; quantifying and generating color stability coefficient and readability maintenance coefficient based on colorimetric features; comparing and verifying each quality indicator with quality indicator thresholds dynamically generated based on order parameters; if verification passes, printing is executed; otherwise, printing parameters are dynamically adjusted before printing is executed. This invention, through multi-feature fusion and dynamic verification adjustment, significantly improves the printing quality, physical durability, and visual readability of QR codes in complex outdoor environments, and overall enhances the adaptability of the QR code printing process.

The present application relates to a kind of preparation method of barley and gastrodia elata beverage, belong to food processing technical field.The existing gastrodia elata beverage preparation method has the problems such as low active ingredient extraction efficiency, difficult to synergistically utilize barley functional components, flavor relies on exogenous addition, product is easy to precipitate etc..The present application is by the specific proportion of mixing maturation of barley and gastrodia elata, inoculation includes saccharomyces cerevisiae, lactobacillus plantarum and streptococcus thermophilus Compound starter carries out solid state fermentation, then it is by the compound enzyme preparation including alpha-amylase, beta-glucanase and pectinase enzymolysis and subsequent processing, and beverage is prepared.The method synergistically improves gastrodia elata element and barley beta-glucan enrichment, creates coordinated flavor, and improves product stability.The obtained beverage is mainly used to provide the flavor beverage with the nutritional and health care function of gastrodia elata and barley.

The invention relates to the technical field of skin care, and discloses a sustained-release composition containing azelaic acid composite lipidosome and application of the sustained-release composition in acne treatment and skin repair. Comprising a composite liposome, an encapsulated active component and a dispersion medium, the composite liposome is composed of a lipid bilayer, the lipid bilayer comprises phospholipid, cholesterol and pegylated phospholipid, and the phospholipid is a mixture of hydrogenated soybean phospholipid and dipalmitoyl phosphatidylcholine; the encapsulated active component comprises a fat-soluble component and a water-soluble component; the water-soluble components comprise a hamamelis virginiana leaf water extract and a herba portulacae extract; the dispersion medium is a phosphate buffer solution; by optimizing lipid composition, introducing surface modification and constructing a multi-layer release system, the invention aims to synergistically exert multiple effects of antibiosis, anti-inflammation, cutin regulation, red fading, repair and the like, and provides an efficient, mild and integrated solution for acne and sequelae skin problems thereof.

The present invention discloses a diquafosol composition, a pharmaceutical preparation containing the same and an application thereof. The present invention provides a diquafosol resin composition, which comprises diquafosol or a pharmaceutically acceptable salt thereof, an anion exchange resin and water. The diquafosol composition provided by the present invention has a high drug adsorption rate and drug loading, can achieve controlled release of the drug, improve the bioavailability of the drug, and is conducive to the drug exerting a stable and sustained therapeutic effect.

The present invention provides a method for manufacturing a polymer electrolyte membrane, comprising the steps of: applying a solvent to a polymer electrolyte membrane having defects on the surface thereof to swell the polymer electrolyte membrane; and a step for applying heat and pressure to the swollen polymer electrolyte membrane.

The utility model discloses an anti -interference's electric power equipment fault diagnosis device, including device body, the shell subassembly of device body outside swing installation, device body includes the wiring port of setting at device body top, and device body bottom is provided with the outgoing line mouth, and the anti -collision angle of fixed connection is all established in device body top four quarters, and device body top is provided with the solar cell panel of connection, and the heat -conducting silicone grease is all daubed in device body inner wall, and the mainboard of fixed connection is established in device body inside, and the silica gel shock pad of setting connection is established in the mainboard top surface, by the electromagnetic shielding sealed cabin body that constitutes by sealing rubber strip, conducting rubber gasket, metal spring piece and metal shield together, and the filter array board (including common mode inductance, X / Y electric capacity) of symmetrical layout, can effectively isolate external interference, provide clean working environment for internal core module.

The invention discloses high-density Sn < 2 + >-doped silicon-boron-gadolinium scintillation glass as well as a preparation method and application thereof, and belongs to the field of scintillation luminescent materials. The high-density Sn < 2 + > doped silicon-boron-gadolinium scintillation glass comprises a main body component, a reducing agent and externally doped Sn < 2 + >, the main body components comprise SiO2, B2O3, Gd2O3, GdF3 and X, and the X is one or more of Al2O3, AlF3, BaO and BaF2; the molar percentages of SiO2, B2O3, Gd2O3, GdF3 and X are as follows: the molar percentage of SiO2 is 5 to 10 mol percent, the molar percentage of B2O3 is 15 to 30 mol percent, the molar percentage of Gd2O3 is 25 to 35 mol percent, the molar percentage of GdF3 is 25 to 35 mol percent, and the molar percentage of X is 5 to 15 mol percent; the sum of the main components is 100 mol%; the molar percentage of the reducing agent is 0.5-2 mol%; the molar percentage of the externally doped Sn < 2 + > is 0.5-2 mol%; the density of the high-density Sn < 2 + > doped silicon-boron-gadolinium scintillation glass is 6-6.26 g / cm < 3 >, the photoluminescence quantum efficiency is 75%-90%, the density, the photoluminescence quantum efficiency and the X-ray imaging resolution of the scintillation glass are greatly improved, and the preparation cost of the high-density scintillation glass is reduced.

The invention relates to the technical field of cosmetic preparations, and discloses a composition containing succinyl glycan and application of the composition to regulation and control of the repetition distance of a liquid crystal lamellar phase, the composition comprises a liquid crystal component and an effective amount of succinyl glycan, wherein the stratified phase repetition distance of liquid crystals in the composition can be effectively adjusted by adding the succinyl glycan, and the thermal stability of the composition is improved; small-angle X-ray scattering (SAXS) proves that the addition of the succinyl glycan enables the repetition distance of the lamellar phase of the liquid crystal to generate a measurable change of 6.2% to 19.4%; the invention provides a novel method for accurately regulating and controlling the liquid crystal structure of the cosmetic from the nanoscale, and the obtained composition has better stability, moisture retention and skin feeling in use.

This invention provides a fused heterocyclic compound and its organic electroluminescent device, specifically relating to the field of organic electroluminescent materials technology. The fused heterocyclic compound provided by this invention possesses excellent electron transport capabilities, suitable HOMO and LUMO energy levels, and a high triplet energy level, which can reduce the electron transport barrier and improve the balance of electron and hole transport. Simultaneously, it can effectively confine holes within the luminescent layer, increasing the probability of effective exciton recombination, thereby reducing the driving voltage, improving luminous efficiency, and extending device lifetime. Furthermore, this fused heterocyclic compound exhibits strong rigidity and a high glass transition temperature, making it less prone to crystallization and aggregation during vapor deposition, thus possessing good film-forming properties and thermal stability. This improves the stability of organic electroluminescent devices and extends the lifespan of electronic components.

The invention relates to the technical field of plant growth regulation, in particular to the field of IPC A01N 37, and more particularly relates to a suspending agent containing mepiquat chloride. Prohexadione calcium as well as preparation and application of the suspending agent. The water-soluble suspending agent comprises the following components in percentage by weight: 5-20% of prohexadione calcium, 1-8% of mepiquat chloride, 3-10% of a dispersing agent, 1-6% of a synergist, 4-10% of an anti-freezing agent, 0.5-3% of a thickening agent, 0.5-3% of an auxiliary agent and the balance of reverse osmosis water. The formula product has relatively strong surface wetting power and can keep a good wetting effect, so that the liquid medicine is easy to spread on the surface of a leaf, the loss of the liquid medicine is reduced, and the pesticide effect is exerted; accelerated heat storage test, cold storage test and freeze thawing test show that the formula sample has excellent stability, and each index is basically unchanged before and after heat storage.

The invention provides a flurbiprofen axetil injection and a preparation method thereof, and belongs to the technical field of biological medicines. According to the flurbiprofen axetil injection provided by the invention, oleic acid is used as a pH regulator to control the pH value of an injection preparation, hydrolysis of soybean oil and egg yolk lecithin can be inhibited, and egg yolk phosphatidyl glycerol (EPG) is added as a co-emulsifier, so that the encapsulation efficiency of an emulsion is remarkably improved, the quantity of flurbiprofen axetil free in water is reduced, and the stability of the injection is improved. The later-stage hydrolysis is obviously reduced. Therefore, the content of the flurbiprofen axetil injection provided by the invention is relatively stable, meanwhile, the quantity of the hydrolysate flurbiprofen is small, the relatively stable pH value of the preparation is ensured, the clinical safety and effectiveness of the preparation are ensured, and the validity period is not less than 2 years.

The utility model discloses a magnetic resonance auxiliary shimming eyeshade which comprises an eyeshade frame, balls are filled in the eyeshade frame, two sides of the eyeshade frame are respectively and rotatably connected with glasses legs through rotating shafts, the interiors of the glasses legs are hollow, and first arc-shaped limiting blocks are uniformly arranged at the bottoms of the glasses legs at intervals. Second arc-shaped limiting blocks are evenly arranged at the top ends of the glasses legs at intervals, first arc-shaped abutting rods are arranged between the first arc-shaped limiting blocks in a sliding mode, second arc-shaped abutting rods are arranged between the second arc-shaped limiting blocks in a sliding mode, and elastic blocks are arranged between the first arc-shaped abutting rods and the second arc-shaped abutting rods in an abutting mode; the first arc-shaped abutting rod and the second arc-shaped abutting rod penetrate through the glasses legs and are connected with extension glasses legs. The small glass beads with the diameter of 2 mm are filled in the eyeshade, the eyeshade has good physical stability and chemical inertness and is easy to clean, disinfect and store for a long time, the glass beads serve as auxiliary shimming devices, the magnetic resonance imaging quality of eye sockets can be improved conveniently, and practicability is high.

The invention provides a waterproof long-acting mosquito-repelling moisturizing soothing emulsion and a preparation method thereof. The waterproof long-acting mosquito-repelling moisturizing soothing emulsion comprises 5.0%-10.0% of butyl acetamido ethyl propionate as a core mosquito-repelling active component; a dual water-encountering stable system composed of a liquid crystal emulsion composition of cetostearyl alcohol olivate and sorbitan olivate and a polymer composition of acrylic acid (ester) copolymer sodium and lecithin is used for constructing a washable bionic protective film on the skin surface to prevent active matters from wading and losing; the cool feeling relieving system is prepared from a compound plant extract of menthol lactate, erythritol and octyldodecanol. Through the liquid crystal emulsification and phospholipid gel network technology, the repellent rate not lower than 90% and the effective protection time exceeding 6 hours in a wading scene are achieved, meanwhile, the product is endowed with remarkable cooling and barrier repairing functions, and the product is mild in property and suitable for children and sensitive skin.

The invention relates to a preparation method of soluble sugar substitute based on Jinxiu sweet tea pigment, and belongs to the technical field of food processing and natural product extraction.The preparation method comprises the steps that Jinxiu sweet tea leaves serve as raw materials, and composite enzymolysis, hot water extraction, membrane separation and concentration, stable blending and spray drying are sequentially conducted. The method comprises the following steps: synergistically releasing sweet taste and pigment components through enzymolysis and extraction, purifying and concentrating through a membrane technology, and protecting through a stabilizer system to finally obtain a powdery product. The sugar substitute has high sweetness and stable brownish red color, realizes integration of sugar and color, can be used as a natural sweetening agent and a coloring agent to be directly used in milk tea, coffee and other food beverages, simplifies the formula and process, and meets the label cleaning requirements.

This invention discloses a method for preparing an internally pressurized MOF-based hollow fiber composite membrane module, belonging to the field of membrane separation technology. The invention involves introducing an aqueous solution containing metal ions and an organic solution containing organic ligands into the shell side and tube side of a hollow fiber membrane module, respectively. By controlling the number of reactions between metal ions and organic ligands on the inner surface of the hollow fiber membrane, a continuous MOF functional layer is precisely constructed. Subsequently, a low-concentration polymer solution is used to repair defects in the MOF layer, resulting in an internally pressurized MOF-based hollow fiber composite membrane module, which is then applied to pervaporation ethanol / water separation. This method simplifies the preparation process of the internally pressurized hollow fiber composite membrane module; the thin inner surface MOF layer reduces molecular diffusion resistance and enhances molecular mass transfer; the surface-coated polymer matrix effectively repairs MOF layer defects, further enhancing molecular separation selectivity and effectively protecting the MOF functional layer; and it enhances the long-term stability of the membrane module.

A novel GLP-1 derivative, compared with GLP-1 derivatives such as liraglutide and semaglutide which are on the market, has comparable or better effect, potency or efficacy, longer or comparable duration of action in vivo or half-life in vivo, has better or comparable GLP-1 receptor binding affinity and has better or comparable DPP-IV stability.

The invention relates to the technical field of extraction of fresh idesia polycarpa fruits, in particular to a preparation method of high-stability phenol-rich oil from fresh idesia polycarpa flesh. The method comprises the following steps: adjusting the pH value of pulp of fresh idesia polycarpa fruits to 4-7, then adding a first enzyme seed and a second enzyme seed, extracting for 0.5-4 hours at the temperature of 30-50 DEG C, centrifuging, and collecting a first emulsion; the first enzyme comprises pectinase, and further comprises at least one of hemicellulase and cellulase; the second enzyme is composed of tannase and glycosidase; and washing the first emulsion with water or a sucrose aqueous solution, centrifuging, and collecting a second emulsion to obtain the oil body. Through simultaneous enzymolysis of the first enzyme and the second enzyme, free polyphenol is generated in situ around the oil body, interaction of the oil body and polyphenol is promoted, part of polyphenol, protein and pectin are combined on the surface of the oil body, part of weak-polarity polyphenol enters the oil body, and the physical and chemical stability of the oil body is synergistically improved.

This invention relates to the field of health food, specifically to a solid beverage for assisting in lowering blood pressure and blood lipids and its preparation method, comprising: 40-45% traditional Chinese medicine extracts, 50-55% food ingredients, and the remainder being excipients; 10-15 parts red yeast rice extract, 5-10 parts hawthorn extract, 5-10 parts gastrodia elata extract, 5-10 parts salvia miltiorrhiza extract, 1-5 parts alisma plantago-aquatica water extract, and 1-5 parts poria cocos water extract; 15-20 parts oat β-glucan powder, 10-15 parts resistant dextrin, 5-10 parts phytosterol micronized powder, and 5-10 parts freeze-dried fruit powder. This solid beverage combines extracts of medicinal and edible herbs such as red yeast rice, salvia miltiorrhiza, and hawthorn with food ingredients, without the addition of chemically synthesized drugs, avoiding the risks of drug interactions and potential side effects, conforming to the principle of food and medicine sharing the same origin, and thus having higher consumer acceptance and compliance.

The application discloses a water-based coating remover for aviation composite paint, which comprises the following components in percentage by mass: paint removal composition 10-25%, surfactant 1-6%, chelating agent 1-5%, corrosion inhibitor 1-5%, stabilizer 0.1-1%, and water; the paint removal composition comprises a paint removal degradation component and a penetrating agent, and the paint removal degradation component is selected from sodium hydroxide and monoethanolamine at a mass ratio of 1:1-1:2. The water-based coating remover for aviation composite paint is environmentally friendly, has low corrosion, is suitable for ultrasonic removal working conditions, has excellent chemical and physical stability in a severe cavitation environment, can remove high-performance organic-inorganic composite paint coatings attached to the surfaces of key components such as high-pressure turbine discs, low-pressure turbine discs and sealing rings, ensures that the paint removal process is continuous and efficient and does not cause damage to expensive base materials, and is suitable for the maintenance and removal of coatings of high-temperature components such as aircraft engines.

A novel GLP-1 derivative, compared with GLP-1 derivatives such as liraglutide and semaglutide which are on the market, has comparable or better effect, potency or efficacy, longer or comparable duration of action in vivo or half-life in vivo, has better or comparable GLP-1 receptor binding affinity and has better or comparable DPP-IV stability.

The present application relates to the field of biological medicine, and specifically provides an anti-LILRB4 monoclonal antibody injection preparation, which comprises an anti-LILRB4 monoclonal antibody, a buffer salt, a protein protective agent, and a surfactant, wherein the pH of the injection preparation is 5.5-6.5. The injection preparation provided by the present application provides a good storage environment for the anti-LILRB4 monoclonal antibody through the synergistic interaction of different contents of the buffer salt, the protein protective agent, and the surfactant, and guarantees the biological activity of the anti-LILRB4 monoclonal antibody. The anti-LILRB4 monoclonal antibody can effectively inhibit the combination of the LILRB4 antigen and its ligand complex, thereby blocking the interaction with the ligand ApoE complex, preventing the activation of the downstream NF-kappa B signal pathway and the release of ARG1, preventing the inhibition of T cell proliferation and the promotion of tissue infiltration, and can be used for treating cancer.

The invention provides a liquid liposome composition which comprises phospholipid, oligosaccharide and water, the weight ratio of the oligosaccharide to the phospholipid is 4: 1-21: 1, and further, the composition further comprises a functional component; further, the composition optionally does not contain or contains a filler. The invention further provides a method for preparing the liquid lipidosome composition, an oral product and application of the liquid lipidosome composition in food and health care products or application of the liquid lipidosome composition in preparation of drugs. The liquid liposome composition disclosed by the invention has the advantages of physical stability, functional component stability and the like.

The invention relates to the technical field of cosmetics, in particular to cellulite tightening cream and a preparation method thereof. The invention relates to a cellulite compacting cream, which comprises a water phase, an oil phase and an additive phase, the water phase comprises the following preparation raw materials: carbomer 980, chlorphenesin, a preservative A and deionized water; the oil phase is prepared from the following raw materials: stearic acid, monoglyceride, an emulsifier, 1618 alcohol and 26 # white oil; the additive phase is prepared from the following raw materials: an anti-allergy agent, a moisturizing anti-aging agent, a sodium hydroxide aqueous solution with the mass concentration of 20%, a thermal sensitizer, a preservative B and essence. Through scientific formula design, the cellulite tightening cream is mild, free of irritation, high in stability, excellent in moisturizing effect and remarkable in tightening and anti-wrinkle effect, skin elasticity can be effectively improved, and the skin is tighter and younger.

The invention discloses a cotton seed treatment suspending agent and a preparation method thereof, and relates to the technical field of pesticide preparations. The cotton seed treatment suspending agent comprises carbofuran raw medicine, carbendazim raw medicine, pyraclostrobin raw medicine, a dispersing agent, a thickening agent, an anti-freezing agent, a coloring agent and a film-forming agent. According to the invention, through the synergistic optimization of the ternary active compound and the special auxiliary agent, multiple prevention and control effects are realized, and a powerful technical support is provided for quality improvement and efficiency improvement of cotton.

This invention discloses a broadband linear graded filter for spectral imaging, possessing high transmittance and excellent stray light suppression performance. The filter employs a multilayer thin-film structure, including an interference cutoff film system above a substrate and a narrowband filter film system below. The narrowband filter film system achieves high transmittance in the 500-800 nm wavelength range through an optimized design using multiple alternating combinations of high and low refractive index materials. The interference cutoff film system effectively suppresses stray light through its long-pass and short-pass design.

The application relates to the technical field of plant beverage processing, and discloses a compound star anise liquor and fructooligosaccharide beverage and a preparation process thereof, which is prepared from 11.8wt%-19.6wt% of star anise liquor extract, 8wt%-15wt% of fructooligosaccharide, 0.1wt%-0.3wt% of anhydrous citric acid, potassium sorbate, sodium ascorbate and purified water; the process comprises the following steps: preparing high-concentration fructooligosaccharide syrup by using part of the purified water, adding the extract and sodium ascorbate into the fructooligosaccharide syrup to obtain a high-viscosity complex mother liquor, sterilizing and rapidly cooling the mother liquor under near-neutral conditions, preparing a deep quenching liquid by mixing the remaining purified water, anhydrous citric acid and potassium sorbate, and synchronously colliding and mixing the cooled mother liquor and the deep quenching liquid to carry out sterile filling. The application improves the dispersion state of the hydrophobic components by using a local high-concentration polysaccharide environment, decouples the heating sterilization process and the acid adjusting process, effectively inhibits polysaccharide hydrolysis and essential oil coalescence, and improves the physical and chemical stability of the finished product.