The invention provides a comfortable wrinkle-resistant fabric, which is prepared by weaving high-twist wrap yarns, wherein the high-twist wrap yarns are wrapped by leather yarns and core yarns; the core yarns are comfortable short fibers; the leather yarns are chemical fiber filaments; the weight ratio of the chemical fiber filaments to the comfortable short fibers is 10-80:20-90; the leather yarns are wrapped on the core yarns in spiral wrapping mode; the degree of twist of the chemical fiber filaments and the comfortable short fibers in the Z-direction or S-direction is 1 to 25T/cm; the chemical fiber filaments are made of terylene, chinlon, polypropylene, PTT, silk, or terylene FDY; and the comfortable short fibers are one or more fibers in pure cotton, viscose, fur, flax, bamboo fiber, corn fiber, soybean fiber and milk fiber. The comfortable wrinkle-resistant fabric has the advantages of high wrinkle resistance, moisture absorption, wear resistance, pilling resistance, sense of flax, air permeability and machine-wash property, comfortable wear, high strength and quick drying of absorbed moisture, and is an ideal comfortable wrinkle-resistant shell fabric.