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2259 results about "Polyelectrolyte" patented technology

Polyelectrolytes are polymers whose repeating units bear an electrolyte group. Polycations and polyanions are polyelectrolytes. These groups dissociate in aqueous solutions (water), making the polymers charged. Polyelectrolyte properties are thus similar to both electrolytes (salts) and polymers (high molecular weight compounds) and are sometimes called polysalts. Like salts, their solutions are electrically conductive. Like polymers, their solutions are often viscous. Charged molecular chains, commonly present in soft matter systems, play a fundamental role in determining structure, stability and the interactions of various molecular assemblies. Theoretical approaches to describing their statistical properties differ profoundly from those of their electrically neutral counterparts, while technological and industrial fields exploit their unique properties. Many biological molecules are polyelectrolytes. For instance, polypeptides, glycosaminoglycans, and DNA are polyelectrolytes. Both natural and synthetic polyelectrolytes are used in a variety of industries.

Hydrogels having enhanced elasticity and mechanical strength properties

InactiveUS6960617B2Great compression modulusEnhanced water absorbencePharmaceutical delivery mechanismAbsorbent padsPolyelectrolytePolymer science
Hydrogels having improved elasticity and mechanical strength properties are obtained by subjecting a hydrogel formulation containing a strengthening agent to chemical or physical crosslinking conditions subsequent to initial gel formation. Superporous hydrogels having improved elasticity and mechanical strength properties are similarly obtained whenever the hydrogel formulation is provided with a foaming agent. Interpenetrating networks of polymer chains comprised of primary polymer(s) and strengthening polymer(s) are thereby formed. The primary polymer affords capillary-based water sorption properties while the strengthening polymer imparts significantly enhanced mechanical strength and elasticity to the hydrogel or superporous hydrogel. Suitable strengthening agents can be natural or synthetic polymers, polyelectrolytes, or neutral, hydrophilic polymers.
Owner:PURDUE RES FOUND INC

Poly(beta-amino alcohols), their preparation, and uses thereof

A new class of poly(beta-amino alcohols) (PBAAs) has been prepared using combinatorial polymerization. The inventive PBAAs may be used in biotechnology and biomedical applications as coatings (such as coatings of films or multilayer films for medical devices or implants), additives, materials, excipients, non-biofouling agents, micropatterning agents, and cellular encapsulation agents. When used as surface coatings, these PBAAs elicited different levels of inflammation, both in vitro and in vivo, depending on their chemical structures. The large chemical diversity of this class of materials allowed us to identify polymer coatings that inhibit macrophage activation in vitro. Furthermore, these coatings reduce the recruitment of inflammatory cells, and reduce fibrosis, following the subcutaneous implantation of carboxylated polystyrene microparticles. These polymers may be used to form polyelectrolyte complex capsules for cell encapsulation. The invention may also have many other biological applications such as antimicrobial coatings, DNA or siRNA delivery, and stem cell tissue engineering.
Owner:MASSACHUSETTS INST OF TECH

Medical articles having regions with polyelectrolyte multilayer coatings for regulating drug release

The medical articles which comprise the following: (a) a ceramic or metallic region whose surface comprises a plurality of depressions, (b) a multilayer coating region comprising multiple polyelectrolyte layers deposited over the surface of the ceramic or metallic region; and (c) a therapeutic agent disposed beneath or within the multilayer coating region. According to another aspect of the present invention, medical articles are provided, which comprise: (a) a ceramic or metallic region, (b) a multilayer coating region comprising multiple polyelectrolyte layers deposited over a surface of the ceramic or metallic region, the multilayer coating region comprising a plurality of protuberances; and (c) a therapeutic agent disposed within regions beneath the protuberances. Also described herein are methods of making such medical articles, and methods of administering a therapeutic agent to a patent using such medical articles.
Owner:BOSTON SCI SCIMED INC

Sulfonated-perfluorocyclobutane polyelectrolyte membranes for fuel cells

A process for preparing a polymer comprising sulfonating a perfluorocyclobutane polymer with a sulfonating agent to form a sulfonated perfluorocyclobutane polymer, wherein the sulfonating agent comprises oleum or SO3 is provided. A process for preparing proton exchange membranes and fuel cells comprising the proton exchange membrane are also provided.
Owner:GM GLOBAL TECH OPERATIONS LLC

Cross-linkable polyionic coatings for medical devices

A method for making an article comprising a core material and a coating thereon, the method comprising the steps of:(a) providing the core material;(b) applying one or more layers of a crosslinkable polycationic material, wherein the polycationic material is a reaction product of:(i) an epoxide of formula (I)wherein X equals bromo, chloro, iodo, or cyano, and R1, R2, R3, R4, independently of one another, are selected from the group consisting of hydrogen, linear or branched C1-C6-alkyl, and linear or branched C1-C6-alkyl which is substituted with halogen, and(ii) a polymer having repeating units comprising one or more secondary or tertiary amine group(s);(c) applying one or more layers of a polyanionic material; and(d) cross-linking the layers of polyelectrolytes formed by steps (b) and (c).The articles obtainable by the method of the invention have desirable characteristics regarding adherence to the core material, durability, hydrophilicity, and wettability and are thus useful for the manufacture of medical articles such as ophthalmic devices.
Owner:ALCON INC

Rehydration and restoration of intervertebral discs with polyelectrolytes

ActiveUS20070150060A1Simple and fast and easy methodEasily reversibleSpinal implantsTissue regenerationPolyelectrolyteFibrosis
The embodiments provide a method for treating an intervertebral disc having a nucleus pulposus and an annulus fibrosis, using one or more polyelectrolyte materials. Additionally, the embodiments provide a method for bulking up an intervertebral disc having a nucleus pulposus and an annulus fibrosis, using one or more polyelectrolyte materials. The methods comprise introducing an amount of the polyelectrolyte materials into the intervertebral disc space without removing nucleus pulposus or annulus fibrosis material.
Owner:WARSAW ORTHOPEDIC INC

Methods of making microarrays with substrate surfaces having covalently bound polyelectrolyte films

Methods for stably associating a polyelectrolyte coating or film to a substrate surface, as well as the coated substrates produced thereby, are disclosed herein. In the subject methods, substrate surfaces are coated with a polyelectrolyte, and the coated substrate surfaces are treated with a bifunctional molecule under conditions sufficient to stably associate the film to the array surface. The subject methods find use in a variety of different applications, including the production of mircoarrarys.
Owner:AGILENT TECH INC

Medical devices having multiple charged layers

InactiveUS20070154513A1Increasing the thicknessGood for uniformity controlStentsSurgeryPolyelectrolyteCharge layer
According to an aspect of the present invention, medical devices are provided, which are adapted for implantation or insertion into a subject and which include at least one multilayer region that contains multiple charged layers of alternating charge. The multiple charged layers, in turn, include the following: (i) at least one charged block copolymer (e.g., a charged block copolymer that contains one or more polyelectrolyte blocks) and (ii) at least one charged therapeutic agent (e.g., a charged therapeutic agent that contains one or more polyelectrolyte blocks).
Owner:BOSTON SCI SCIMED INC

Automated layer by layer spray technology

ActiveUS8234998B2Minimal and human interactionDesigned can be scalableMembranesSemi-permeable membranesPolyelectrolyteHuman interaction
The present invention comprises an automated apparatus capable of spray depositing polyelectrolytes via the LbL mechanism with minimal or no human interaction. In certain embodiments, the apparatus sprays atomized polyelectrolytes onto a vertically oriented substrate. To counteract the effects of irregular spray patterns, the substrate is preferably slowly rotated about a central axis. In certain embodiments, the apparatus also includes a forced pathway for the droplets, such as a pathway created by using a vacuum. In this way, a thicker or three-dimensional substrate can be coated. In certain embodiments, the apparatus is designed so as to be scalable. Thus, through the use of multiple instantiations of the apparatus, a large or irregularly shaped substrate can be coated. Rolls of textile can therefore be coated using the apparatus. Additionally, the present invention includes a method to uniformly coat a substrate, such as a hydrophobic textile material, using aqueous solutions of polyelectrolytes.
Owner:MASSACHUSETTS INST OF TECH

Cross-linkable polyionic coatings for medical devices

A method for making an article comprising a core material and a coating thereon, the method comprising the steps of:(a) providing the core material;(b) applying one or more layers of a crosslinkable polycationic material, wherein the polycationic material is a reaction product of:(i) an epoxide of formula (I)wherein X equals bromo, chloro, iodo, or cyano, and R1, R2, R3, R4, independently of one another, are selected from the group consisting of hydrogen, linear or branched C1-C6-alkyl, and linear or branched C1-C6-alkyl which is substituted with halogen, and(ii) a polymer having repeating units comprising one or more secondary or tertiary amine group(s);(c) applying one or more layers of a polyanionic material; and(d) cross-linking the layers of polyelectrolytes formed by steps (b) and (c).The articles obtainable by the method of the invention have desirable characteristics regarding adherence to the core material, durability, hydrophilicity, and wettability and are thus useful for the manufacture of medical articles such as ophthalmic devices.
Owner:ALCON INC

Method to fabricate microcapsules from polymers and charged nanoparticles

InactiveUS20050158390A1Economically and environmentally favorableRequirement for reaction conditionMaterial nanotechnologyPowder deliveryPolyelectrolyteNanoparticle
A method for making hollow nanoparticles, comprises a) providing an amount of a polyelectrolyte having a charge, b) providing an amount of a counterion having a valence of at least 2, c) combining the polyelectrolyte and the counterion in a solution such that the polyelectrolyte self-assembles to form spherical aggregates, and d) adding nanoparticles to the solution such that nanoparticles arrange themselves around the spherical aggregates. The polyelectrolyte may have a positive or negative charge. The charge ratio R of total charge of the counterions to the total charge of the polyelectrolyte is greater than 1.0.
Owner:RICE UNIV

Material system for use in three dimensional printing

A material system for use in a 3D-printing, which exhibits a higher form stability. The material system contains binder and solvent as well as optional filler materials. The binder is soluble in the solvent, as well as two complementary polyelectrolytes, and / or an initiator for a cross linking reaction of the binder. The advantage of such a mixed material system is comprised in the essentially higher binder force between the individual particles. This enhanced binder force results either from the acid-base linkages, which form between the complementary polyelectrolytes, or from the supplemental networking initiated by the initiators, or from both. Substantially higher binding forces between the individual particles means at the same time a substantially higher shape stability of the 3D-printing product.
Owner:DAIMLER AG

Localized delivery of nucleic acid by polyelectrolyte assemblies

The present invention provides implantable medical devices coated with polyelectrolyte assemblies that are fabricated by layer-by-layer deposition of nucleic acid and polycation. Such devices facilitate the local delivery of a nucleic acid contained in the polyelectrolyte assembly into a cell or tissue at an implantation site. Also provided are methods of fabricating and using implantable medical devices according to the invention.
Owner:WISCONSIN ALUMNI RES FOUND

Electronically-Degradable Layer-by-Layer Thin Films

A decomposable thin film comprising a plurality of alternating layers of net positive and negative charge. At least a portion of the positive layers, the negative layers, or both, comprise a polyelectrolyte.
Owner:MASSACHUSETTS INST OF TECH

In-situ formable nucleus pulposus implant with water absorption and swelling capability

Embodiments of the invention relate to a curable nucleus pulposus implant having water absorption and swelling capabilities, compositions for producing the curable nucleus pulposus implants, and methods of using the curable nucleus pulposus implants. The curable nucleus pulposus implant can be created from a polymer blend composition comprising a ratio of a curable material and at least one hydrophilic polymer. The resulting polymer blend composition may be used to generate curable nucleus pulposus implants to treat a number of disease and / or disorders, such as herniated discs. The curable nucleus pulposus implants may further contain polyelectrolytes and elastomer compounds, as well as pharmacological and biological agents.
Owner:WARSAW ORTHOPEDIC INC

Membrane electrode assembly for polymer electrolyte fuel cell

A membrane electrode assembly for a polymer electrolyte fuel cell characterized by using, as solid polyelecrolyte of at least one of a membrane and a catalyst binder, a fluorinated sulfonic acid polymer with a monomer unit represented by the following general formula (3): (wherein Rf1 is a bivalent perfluoro-hydrocarbon group having a carbon number of from 4 to 10), wherein said fluorinated sulfonic acid polymer has melt flow rate (MFR) not higher than 100 g / 10 min at 270° C. when a —SO3H group in said polymer is converted to —SO2F.
Owner:ASAHI KASEI KK

Peroxycarboxylic acid-based polyelectrolyte capsule system having a long shelf life

A multilayer capsule is comprised of a core-shell structure wherein the core portion comprises at least one organic peroxycarboxylic acid in solid particulate form and the shell portion comprises at least one coating layer comprising a material selected from the group consisting of at least one polyelectrolyte, at least one ionic surfactant or a combination thereof.
Owner:HENKEL KGAA

Medical devices having multiple layers

Described herein are medical devices which are configured for implantation or insertion into a subject, preferably a mammalian subject. The medical devices contain one or more multilayer regions, which contain: (a) one or more (typically a plurality of) charged nanoparticle layers and (b) one or more (typically a plurality of) charged polyelectroyte layers. Such multilayers have a number of desirable attributes, including high strength, non-compliance, and flexibility. Also described herein are methods of making such devices.
Owner:BOSTON SCI SCIMED INC

Superparamagnetic colloidal nanocrystal structures

Monodisperse colloidal nanocrystal clusters of magnetite (Fe3O4) with tunable sizes from about thirty to about three hundred nanometers have been synthesized using a high-temperature hydrolysis process. The colloidal nanocrystal clusters are capped with polyelectrolytes, and highly water soluble. Each cluster is composed of many single magnetite crystallites, thus retaining the superparamagnetic behavior at room temperature. The combination of superparamagnetic property, high magnetization, and high water dispersibility makes the colloidal nanocrystal clusters ideal candidates for various important biomedical applications such as drug delivery and bioseparation. The present invention is further directed to methods for forming colloidal photonic crystals from both aqueous and nonaqueous solutions of the superparamagnetic colloidal nanocrystal clusters with an external magnetic field applied thereto. The diffraction of the photonic crystals can be tuned from near infrared to visible and further ultraviolet spectral region by varying the external magnetic field.
Owner:RGT UNIV OF CALIFORNIA

Process for preparing substrates with porous surface

A process for preparing nanoparticle coated surfaces including the steps of electrostatically coating surfaces with polyelectrolyte by exposing the surface to a solution or suspension of polyelectrolyte, removing excess non-bound polyelectrolyte, then further coating the particles with a multi-layer of charged nanoparticles by exposing the polyelectrolyte-coated surface to a fluid dispersion including the charged nanoparticles. The process steps can optionally be repeated thereby adding further layers of polyelectrolyte followed by nanoparticles as many times as desired to produce a second and subsequent layers. The polyelectrolyte has an opposite surface charge to the charged nanoparticles and a molecular weight at the ionic strength of the fluid that is effective so that the first, second, and subsequent layers independently comprise a multiplicity of nanoparticle layers that are thicker than monolayers.
Owner:ADVANCED MATERIALS TECHNOLOGIES

Polyelectrolyte complex films for analytical and membrane separation of chiral compounds

The present invention is directed to enantioselective polyelectrolyte complex films. Further, said films may be free or isolated membranes, or coatings on substrates such a porous substrates, capillary tubes, chromatographic packing material, and monolithic stationary phases and used to separate chiral compounds. The present invention is also directed to a method for forming such enantioselective polyelectrolyte complex films.
Owner:FLORIDA STATE UNIV RES FOUND INC

Method for preparing biomedical material of static self-assembly modified nano fiber

The invention relates to a method for preparing a biomedical material of a static self-assembly modified nano fiber, which is characterized by comprising the following concrete steps of: stirring and dissolving a water-insoluble macromolecular polymer for spinning in a solvent in a stirring kettle at room temperature to obtain an electric spinning raw material with the weight percentage of 5-30 percent; adding the electric spinning raw material into a static spinning device and statically spinning to obtain a nano fiber template material; soaking the nano fiber template material into a weak polymerized electrolyte aqueous solution which has the concentration of 0.01-10g / ml and an opposite charge, adsorbing for balance and drying; soaking the dried material into the weak polymerized electrolyte aqueous solution which has the concentration of 0.01-10g / ml and the opposite charge, adsorbing for balance, washing by distilled water for 5-30 minutes and drying; and obtaining the biomedical material of the static self-assembly modified nano fiber. The invention has simple molding and high bioactivity.
Owner:DONGHUA UNIV

Biological material using electrostatic attraction layer-layer self-assembled modified polyester material as surface with cell compatibility

Fistly, said ivnention utilizes polyamine aminolyzed polyester polymer surface to obtain polymer whose surface has free amine group, then uses acid to make acidification to make polymer surface possess positive charge, and utilzies electrostatic attraction layer-to-layer self-assembling method to alternatively assemble single layer or several layers of different polyanions and polycations with biological activity on its surface, and these biological activity polyelectrolytes which are layer-to-layer self-assembled still retain their original biological activity so as to obtain the invented plane membrane and three-D porous support material with cell compatibility and its product.
Owner:ZHEJIANG UNIV
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