189results about How to "Improve biological activity" patented technology

The invention discloses a nitrogen heterocyclic ring dichloro-allyl ether compound which is shown in a formula (1) and has the insecticidal activity, and a preparation method thereof, wherein, R, n, A, and B are limited, as shown in an instruction book.

The present invention provides methods of treating or preventing disorders or conditions associated with an undesirable level of a satiety factor by administering to a subject in need thereof an effective amount of an agonist or antagonist of a satiety factor. The present invention also provides methods of selecting a subject for therapy with an agonist or antagonist of a satiety factor. Exemplary disorders or conditions associated with an undesirable level of a satiety factor include overweight, obesity, metabolic disorders, hypertension, lipid related disorders, anorexia and type II diabetes.

The invention belongs to the technical field of nano-silver antibacterial materials and discloses an aminated polyethylene glycol functional graphene oxide loaded nano-silver antibacterial material, a preparation method of the antibacterial material and an application of the antibacterial material in the fields of bacteriostasis and sterilization. The method comprises the following steps: adding aminated polyethylene glycol into an aqueous solution of graphene oxide, adding 1-ethyl-(3-dimethylaminopropyl) carbonyldiimine hydrochloride and N-hydroxy succinimide, regulating the pH value, stirring, and reacting, thereby obtaining the aminated polyethylene glycol modified graphene oxide; preparing the aqueous solution of the graphene oxide, adding silver nitrate, heating until the solution is boiled after dissolving, adding sodium citrate or NaBH4 aqueous solution, reacting, and cooling, thereby obtaining the aminated polyethylene glycol functional graphene oxide loaded nano-silver antibacterial material. The antibacterial material prepared by the invention has good water solubility and stability, the loading efficiency and antibacterial activity are obviously improved, and the antibacterial material has obvious antibacterial activity and can be widely applied to the fields of bacteriostasis and sterilization.

The invention relates to strontium calcium silicate-containing biological ceramic as well as a preparation method and an application thereof. The general formula of chemical constitution of the strontium calcium silicate-containing biological ceramic is Ca1-xSrxSiO3, wherein x is equal to 0.015 to 0.25. The strontium calcium silicate-containing biological ceramic is ceramic particles or porous ceramic. The strontium calcium silicate-containing biological ceramic disclosed by the invention, obtained by doping strontium into calcium silicate biological ceramic, has the advantages of both calcium silicate ceramic and strontium and is good in bioactivity and degradability, and silicon ions released by degradation of the strontium calcium silicate-containing biological ceramic have good effects of promoting proliferation of bone cells and stimulating expression of osteogenesis gene. Beside, an alkaline micro-environment formed by degradation of the material can achieve the effect of neutralizing an acidic micro-environment of osteoporotic bone; the strontium ions released by degradation have good dual functions of promoting osteogenesis and inhibiting the activity of osteoclasts. Therefore, the strontium calcium silicate-containing biological ceramic has wide application prospects in the field of treatment on bone defect repair accompanied with osteoporosis.

The invention relates to Dongfeng snail powder compound feed comprising basal feed which comprises the components in percentage by weight: 5 percent of kelp powder and 0.1-0.15 percent of nanometer trace mineral element and also comprises Vc condensed phosphate, beta-hyskon, phytase and xylo-oligosaccharide. The production method comprises the following steps of: preparing the basal feed materials in proportion after the basal feed materials are initially cleaned and magnetically selected, micronizing after the materials are evenly mixed, adding trace mineral elements, Vc condensed phosphate, beta-hyskon, phytase and xylo-oligosaccharide which are diluted and evenly mixed in multiple levels in advance into the crashed basal feed to mix secondly and weighing and packing to obtain the Dongfeng snail powder compound feed. The Dongfeng snail powder compound feed can supply complete nutritional requirements for Dongfeng snails, promote growth, obviously reduce feed coefficients, increase the immunity of the Dongfeng snails, reduce diseases and improve a survival rate.

The invention discloses a method for preparing probiotics microcapsule and its application, which belongs to the biological technical field of foodstuffs. According to the invention, the method comprises the following steps: isometrically mixing a sodium alginate solution and a modified starch solution, then mixing with probiotics, spraying into a CaCl2 solution through a nozzle of a sprayer, standing and solidifying, washing by normal saline, filtering, and drying to obtain the microcapsule. The invention has the advantage of substantially raising capability of the probiotics for opposing extremity environment of the human body, and plays health care effect finally, thereby the method provided in the invention provides novel technical ideas for probiotics micro encapsulation.

The invention relates to compositions, and uses thereof, which are beneficial for eukaryotic cells in culture, and methods for their use in promoting cell growth, viability and recombinant protein expression. The methods disclosed in the present application are useful, for example, for improving cell viability and in accelerating the rate of cell growth of cells grown in culture. In one aspect, the supplements of the invention are useful for improving or enhancing the yield of the recombinant proteins from the cell cultures.

There is provided an agrochemical formulation aid composition for preparing bioactive and sprayable agrochemicals, wherein various components for the composition were selected from mineral oil paraffinic distillate and/or aromatic hydrocarbon distillate; 2N-octanol; oleyl-cetyl; alcohol polyoxyethylene (2) oleylether; polyoxyethylene (8) nonylphenolethin and/or ethoxylated tallow amine blend; lauryl sulphate; fatty alcohol alkoxylate; terpenes, diammonium phosphate; tetrasodium ethylene diamine tetracetate; cab-o-sil; fatty acid methyl ester; (C18) free fatty acid blend; N-butanol; and methyl alcohol. Also provided are methods of preparing the formulation aid composition on site by mixing various components and methods of preparing sprayable and bioactive agrochemical systems using the formulation aid and non-formulated or formulated agrochemicals. Also provided are uses of the formulation aid in preparing sprayable and bioactive agrochemical systems for controlling pests.

The invention discloses a PEGylated scutellarin compound and a preparation method thereof. The PEGylated scutellarin compound is as the shown formula (IV) and the PEGylated scutellarin compound can be applied to preparing medicaments applied to treating cerebral thrombosis, cerebral infarction, cerebral apoplexy, sequelaes caused by cerebral apoplexy, coronary heart disease or angina. Compared with the original scutellarin compound, the water solubility of the scutellarin compound is increased obviously; simultaneously, pharmacodynamics experiment on the mice model of cerebral ischemia-reperfusion shows that: compared with the original medicament, the biological activity of the scutellarin promedicament is strengthened obviously.

The invention discloses a method for treating micro polluted water by using a biological nitrogen removal and physicochemical enhanced phosphorus removal combined process, and belongs to the technical field of water pollution purification treatment. The inlet water enters a biological contact oxidation tank through a lifting pump, and flexible fibers are used as a film forming filler and a rotary fan is adopted for aeration in the tank; the outlet water overflows to a quick filter tank, the bottom of the tank is provided with a backwashing pipeline, and the tank is periodically backwashed to avoid blockage; the outlet water of the quick filter tank passes through a deoxidization tank from bottom to top, so dissolved oxygen (DO) in the water is reduced, and a favorable condition is provided for subsequent denitrification; an facultative tank realizes denitrification by adopting a camphorwood leaf and ceramsite combined filler to remove TN; the outlet water flows into a flocculation reaction tank and is subjected to enhanced coagulation with stirring; and soil-liquid separation is performed in a phosphorus removal sedimentation tank, and the supernate flows through an anthracite filler device from bottom to top and finally flows into a lake. The method ensures that the substances such as chemical oxygen demand (COD), NH4+-N, NO3--N, TN, TP, SS, Chla and the like in the outlet water are furthest removed, and the outlet water reaches the class III water quality standard of Environmental Quality Standards for Surface Water (GB3838-2002).

The invention discloses a liquid fertilizer for drip irrigation for a saline and alkaline inland. The liquid fertilizer comprises the following components: 20 to 40 parts of fulvic acid extracted by microbial fermentation, 20 to 30 parts of urea, 5 to 10 parts of ammonium polyphosphate, 10 to 20 parts of potassium dihydrogen phosphate, 2 to 5 parts of an inorganic additive, 2 to 3 parts of ferrous sulfate, 2 to 3 parts of zinc sulfate, 2 to 3 parts of manganese sulfate, and 0.5 to 1 part of 15 to 20wt% plant growth regulator ethanol solution. The pH value of the fertilizer is 3.5 to 4.0. The liquid fertilizer for drip irrigation provided by the invention has the advantages of effectively reducing the pH value of crop rhizosphere soil, improving the bioavailability of soil nutrients, achieving the balanced supply of water and nutrients, and improving the water and fertilizer use efficiency.

Proteases are added to Platelet Rich Plasma (PRP) along with calcium and thrombin to activate latent TGF-β. The proteases include plasmin, calpin, MMP-9, thrombospondin, transglutaminase, the mannose 6-phosphate receptor (M6PR), furin, substilisin-like endoproteases, and integrins. Dermatopontin can also be added to the PRP to enhance its biologic activity.

The invention discloses a preparation method of a pure titanium surface Ag/Sr co-doped TiO2 porous film. A pure titanium sample and a TiAg alloy target are oppositely put in a magnetron sputtering film plating furnace, and argon is fed to pre-sputter and clean the sample after vacuumizing; then, a source pole and workpiece voltage are switched on to form a TiAg alloy film on the surface of the sample through the argon ion bombardment and the metal ion deposition and dispersion; and an alloyed sample, serving as an anode, is dip in electrolyte, a stainless steel electrolytic cell serves as a cathode, and a direct-current pulse micro-arc oxidation device is adopted to perform the micro-arc oxidation to obtain the Ag/Sr co-doped TiO2 porous film under a certain conditions of current density, duty ratio and direct-current pulse frequency. The film, prepared by the method, is excellent in bonding force, has long-acting antibacterial property and excellent biocompatibility, and is simple in operation, excellent in repeatability, suitable for large-batch production and capable of preparing advanced medical implant bone substitute materials.

The invention discloses surface nano-scale modified calcium phosphate bioactive ceramic and a preparation method thereof. The surface nano-scale modified calcium phosphate bioactive ceramic comprises a porous calcium phosphate ceramic base body and a nano modifying layer. The preparation method of the surface nano-scale modified calcium phosphate bioactive ceramic comprises the following steps: carrying out surface nano-scale modification onto the porous calcium phosphate ceramic base body by a hydrothermal method in acid liquor; and self-assembling the material surface to form a layer of nano calcium phosphate by modification treatment. Therefore, the material surface/interface has a relatively large specific surface area and is beneficial to adsorbing osteogenesis-associated proteins and cells; after being planted into a body, the material can quickly release calcium and phosphor ions to promote osteogenesis, so that the material has better biological activity and osteoconduction; meanwhile, the ceramic has better mechanical performance.

The invention discloses 1-substituted-5-amino-4-pyrazol di-1,3,4-diazole sulfur ether or 1,3,4-diazole sulfone derivatives and an application thereof. Structures of the derivatives are as shown in formulas I and II, wherein R1 is alkyl, alkenyl, phenyl, substituted phenyl, benzyl, substituted benzyl, heterocyclic radical and substituted heterocyclic radical; and X is O and S. The compounds can be applied as pesticides and pesticide additives for preventing and treating plant virus diseases.

The invention provides an organotin-oxygen cluster containing ferrocene pyrazole. The cluster is characterized in that the complexes with the following chemical formulas are prepared from a ligand 3-trifluoromethyl-5-ferrocene pyrazole acetic acid (LCOOH) and monobutyltin oxide, dibutyltin oxide and triphenyltin hydroxide respectively: [BuSnO(OOCL)]6, [Ph4Sn2O(OCH3)(OOCL)]2 and [Bu4Sn2O(OOCL)2]2.The cluster has inhibiting effects on human lung cancer cells (A549), hepatoma cells (HepG2) and mouse melanoma (B16-F10) and the inhibiting effects are obviously superior to the inhibiting effects of the control drugs 5-fluorouracil and cisplatin, so the cluster can be applied to preparing the anti-tumor drugs.

The invention relates to a production method of an anti-bacterial SBR (styrene butadiene rubber) foaming material. The ingredients includes, by weight parts, 20 to 40 parts of natural rubber, 60 to 80 parts of main SBR materials, 10 to 15 parts of process/operation auxiliaries, 20 to 30 parts of vulcanization /foaming auxiliaries, 40 to 50 parts of processing oil and 120 to 150 parts of reinforcing filler. The production method includes steps of firstly, masticating; secondly, mixing; thirdly, opening smelting; fourthly, fine smelting; fifthly, open smelting secondarily; sixthly, extruding; seventhly, vulcanizing and eighthly, foaming. The production method is characterized in that 3 to 5 parts of nanometer silver powder are added into the ingredients according to mass ratio, the first step of the production method includes feeding the natural rubber and the nanometer silver powder into an open smelting machine or a fine smelting machine to realize mastication, and the second step of the production method includes feeding a primary product of the first step, the main SBR and the process/operation auxiliaries into the fine smelting machine to mix. The production method of the anti-bacterial SBR foaming material has the advantages that anti-bacterial nanometer silver powder can prevent physiological breeding of bacteria while original characteristics of the foaming material are kept.

The invention provides a treatment method for brown Windsor soap element industrial waste water and the synthesis utilization. The method hydrolyses brown Windsor by acid, filters out the high acidity organic waster water, reclaims the acid and water by distilling method, the distilled remained liquid is filtered, the solid can be used as reclaimed soap element or medical or harmless farm insecticide. The filtered liquid is put into ground phosphorite and produces the phosphate fertilizer, or be reclaimed as acid to be sued circularly. The cleaning water of the dregs are poured into biological pool.

The invention discloses a biomedical TiNbSn-HA composite material with low elastic modulus and a preparation method of the biomedical TiNbSn-HA composite material, relating to a composite material and a preparation method thereof and mainly solving the problem of implant falling caused by a stress shielding phenomenon easily generated because the elastic modulus of the traditional titanium alloy/HA composite material is far higher than that of a human bone and the elastic modulus of the traditional titanium alloy/HA composite material is not matched with that of the human bone after the traditional titanium alloy/HA composite material is implanted in a human body. The method comprises the steps of firstly, weighing; secondly, preparing mixed powder; thirdly, preparing composite nanopowder; and fourthly, preparing a high-density composite material block to obtain the biomedical TiNbSn-HA composite material with the low elastic modulus. The invention discloses the biomedical TiNbSn-HA composite material with low elastic modulus and the preparation method of the biomedical TiNbSn-HA composite material.

The invention discloses an enhanced synchronous nitrification and denitrification process for adding AHLs signal molecules into a biological moving bed process, and belongs to the technical field of sewage treatment. According to the present invention, the process is based on a biological moving bed process, and comprises: improving the biological film forming process and the operating process ina moving bed biofilm process and a biofilm and active sludge composite process, and adding AHLs signal molecules, such that the quorum sensing QS crucial to the formation of bacterial biofilms can bepromoted; and a certain proportion of the AHLs signal molecule mixture with a certain concentration is added to the biological moving bed process, such that the biological activity is improved, the biomass is increased, the growth and biofilm formation of the biological film on the carrier is accelerated, the functional bacterial flora structure in the system is optimized, the biological diversityof the system is improved, the synchronous nitrification and denitrification nitrogen removal effect of the system is further enhanced, and the ammonia nitrogen and the total nitrogen in the effluentcan meet the requirements of standard emission.

The invention discloses a method for extracting lysozyme from egg white or whole egg juice, and belongs to the technical field of biology. The method comprises the following steps: (1) adding 1-10-fold water to the egg white or whole egg juice, mixing evenly, and filtering out impurities to obtain a diluent; (2) carrying out ultrafiltration on the diluent with an ultrafiltration membrane to obtain a thin liquid and a thick liquid; (3) adding resin to the thin liquid for adsorption, wherein the weight ratio of the thin liquid to the resin is (1:3) to (1:8), and the adsorbed resin is obtained; (4) eluting the adsorbed resin with a 0.001-0.5mol/L NaCl water solution to obtain an eluant; (5) desalting the eluant with the ultrafiltration membrane to obtain ultrafiltrate; and (6) drying the ultrafiltrate to obtain the lysozyme. The method is simple and fast in process, mild in condition, and free of complicated equipment; high-purity and high-bioactivity lysozyme can be obtained; and the defects of an existing lysozyme preparation technology can be overcome.

The invention discloses a carbamic acid rotenone oxime ester having a chemical structural formula and a stereoscopic structural formula as shown in a formula I, and a preparation method of carbamic acid rotenone oxime ester I comprises the reaction between rotenone oxime and isocyanate in the presence of a phase-transfer catalyst or an acid binding agent. The carbamic acid rotenone oxime ester is obtained through filtration, washing and drying after the reaction is finished. The new carbamic acid rotenone oxime ester compound can be used for preparing pesticides and bactericides.

The invention relates to porous nano-ceramic constructed by hydroxyapatite nanorods or sheets and a preparation method thereof, belonging to the technical field of biological materials. The method comprises the following steps: performing nanocrystallization on porous ceramic containing tricalcium phosphate by using a hydrothermal method, namely mixing an ethylenediaminetetraacetic acid water solution with the concentration of 0-0.5mol/L and a water solution of Ca(NO3)2.4H2O and (NH4)2HPO4 with the concentration of 0-0.5mol/L and the molar ratio of Ca: P of 1.67 to get a mixed water solution; regulating the pH value by using hydrochloric acid and sodium hydroxide; and further adding the porous ceramic containing tricalcium phosphate and the mixed water solution into a hydrothermal reaction kettle for reaction, and controlling temperature and time to get the porous nano-ceramic constituted by the hydroxyapatite nanorods or nano-sheets. Compared with traditional calcium phosphate porous ceramic, the porous nano-ceramic constructed according to the invention has the advantages of higher biological activity and improved degradability; and the preparation method is simple, high in repeatability and capable of realizing large-scale production.

The invention discloses a simultaneous removal method of manganese and nitrate in underground water, comprising the following steps: Step 1, under an enclosed anaerobic condition, a nutrient solution I is added into underground water to be treated for culture and then settled sludge is collected after the culture; Step 2, a nutrient solution II is added into the settled sludge for culture, a supernatant is dumped, and the sediment undergoes deep culture; and Step 3, dispersed sludge obtained in the Step 2 is used for filter material film-forming to obtain a biological packing, and underground water to be treated passes through the biological packing to simultaneously remove manganese and nitrate. In the prior art, technicians use two reaction devices to respectively remove nitrate and manganese ion. The traditional method is subverted through the above biological method for underground water treatment. By the method of the invention, simultaneous removal of nitrate and manganese ion in underground water can be realized, and infrastructure and operation costs are greatly reduced.

The invention discloses a pesticide composition containing imidacloprid, which contains an active component A, an active component B, and an active component C. The active component A is imidacloprid; the active component B is fludioxonil; and the active component C is difenoconazole. The composition of the invention can control diseases and insect attack of wheat, has obvious synergistic effect, extends the insecticidal and bacteriocidal spectra, has high activity on wheat sheath blight, root rot, piercing-sucking insects and aphids, decreases the drug dosage, reduces residual quantity, and mitigates environment pollution.

The invention relates to the field of daily chemicals and the medicine industry, in particular to an amphiphilic amido inulin and a preparation method thereof. The amphiphilic amido inulin is shown in a formula (1), wherein R is H, CH3, CH3CH2CH2, (CH3)2CH or C6H5; and the average numeric area of n is 10-35. The preparation method comprises the following steps of: performing halogenating reaction on the primary hydroxyl of inulin; after reaction, reacting with sodium azide or lithium azide at 40-70 DEG C for 8-24 hours; purifying to obtain 6 azide-3,4-succinate-6 deoxidized inulin; and reducing the 6 azide-3,4-succinate-6 deoxidized inulin by utilizing triphenylphosphine, so as to obtain the amphiphilic amido inulin. According to the pepaation method, the amphiphilic amido inulin is obtained by virtue of an effective synthesis means, halogen is used for replacing the primary hydroxyl of inulin so as to cause that the sixth-site group of the inulin is ionized easily, acyl is used for protecting the naked hydroxy, at the othe sites, of the inulin, azido is used for performing nucleophilic substitution on the sixth-site group which is ionized easily, and the product is reduced so as to obtain the amphiphilic amido inulin with high substitution degree. The preparation method has the advantages that the synthesis step is simple, popularization is easy, and required equipment and raw materials are easily available. The formula (1) is shown in the specification.

The present invention relates to five crystalline forms (Iguratimod) of N-[3-(formamido)-4-oxy-6-phenoxy-4H-1-benzo pyran-7-yl]-methane sulfonamide. The present invention also relates to the application of the crystalline forms (Iguratimod) in preparing medicine for rheumatic arthritis, medicine composition containing the crystalline forms (Iguratimod) and the preparation process of the crystalline forms (Iguratimod).

The invention discloses a solid high-activity organic water-soluble fertilizer, belongs to the field of fertilizers for crops and particularly relates to a solid high-activity organic water-soluble fertilizer using organic acid as a carrier. The organic water-soluble fertilizer comprises the following components in parts by weight: 8 to 12 parts of potassium nitrate, 32 to 48 parts of urea, 15 to 22 parts of potassium chloride or potassium sulfate, 3 to 5 parts of boric acid, 12 to 18 parts of concentrated fulvic acid powder and 7 to 11 parts of amino acid powder. The water-soluble fertilizer has the characteristic of slow release, can effectively improve the utilization rate of nutrients in the fertilizer and improve the self-defense capability of plants on pests and diseases, has cell solidification and permeation effects and can regulate the growth of the plants in a metabolic pathway in the plants, namely, the water-soluble fertilizer increases the tillering capability of the crops, promotes growth and development of roots, stems, leaves and flowers, greatly improves the yield, the quality and the stress resistance of the crops and has an effect of improving soil.

The invention relates to a method for preparing a strontium-doped calcium phosphate coating on the surface of magnesium alloy through a one-step hydrothermal method. The method includes the steps that a coating solution is placed in a reaction still, and a magnesium alloy sample treated through alkali is soaked into the coating solution; the reaction still is placed in a drying oven, and heat preservation lasts for 1-3 h at the temperature of 90-110 DEG C; and finally, the reaction still is cooled to an indoor temperature along with the drying oven, and the magnesium alloy sample is taken out, rinsed with deionized water and then dried. The prepared coating on the surface of the magnesium alloy is structurally divided into an upper layer and a lower layer. The upper layer of the coating is of a flower-shaped cluster structure, the lower layer of the coating is of a compact sheet structure, and the coating thickness is 1-2 microns. In an in-vitro immersion experiment, deposited hydroxyapatite appears on the first day to the third day, and good biological activity is achieved; and moreover the alternating-current impedance is 7500-14000 ohm.cm<2>. The biological activity of the magnesium alloy is improved, and meanwhile corrosion resistance of the magnesium alloy in simulated body fluid is improved. The preparation technology is simple, the method is environmentally friendly, and great commercial popularizing value can be achieved.

The invention discloses a method for separating and purifying vitamin K2 in bacillus subtilis natto. The method comprises the following steps: acquiring vitamin K2 extract, acquiring a vitamin K2 column stock solution, acquiring a low-purity vitamin K2 concentrated solution, acquiring a high-purity vitamin K2 concentrated solution, acquiring high-purity vitamin K2, and acquiring vitamin K2 crystals. The method has the advantages that (1) an obtained vitamin K2 crystal product is high in purity, bioactivity and recovery rate; (2) a separation and purification process is easy to operate, mild in condition and high in treatment capability; (3) each organic solvent can be recycled for industrial application.