159 results about "Nerves tissue" patented technology

The invention discloses an electrical stimulation type nerve regeneration method based on calcium signal regulation and control, and relates to the technical field of electrical stimulation type nerve regeneration, and the method comprises the following steps: based on a Schwann cell population calcium signal response feature set, identifying whether the calcium ion concentration is in a microliter stage which breaks through a lowest activation threshold and does not reach a stable state; judging whether the target nervous tissue is in a calcium signal activation critical state or not based on the behavior mode change of the Schwann cell population; based on the judgment result of the calcium signal activation critical state, an electrical stimulation adjustment control instruction is generated in real time in combination with the calcium ion concentration fluctuation trend and Schwann cell population response characteristics, and the calcium ion concentration stability is optimized and the activation state is maintained by adjusting the electrical stimulation intensity, the electrical stimulation pulse width, the electrical stimulation waveform type and the electrical stimulation application time sequence. According to the method, the problem that a calcium signal is difficult to recognize and dynamically optimize in a microliter stage is solved, and precise maintenance of Schwann cell activation and improvement of nerve regeneration efficiency are realized.

The invention discloses an anesthesia nerve precise positioning method and system based on ultrasonic image auxiliary processing, and the method comprises the following steps: obtaining a real-time dynamic ultrasonic image sequence of a target region through an ultrasonic image data collection device, carrying out the multi-modal data fusion processing, and generating an enhanced ultrasonic image data set; performing three-dimensional semantic segmentation on the enhanced ultrasonic image data set based on a preset anesthesia nerve region segmentation model, and extracting morphological characteristics and spatial distribution information of a target nerve tissue; generating a three-dimensional navigation path grid based on the extracted morphological characteristics and spatial distribution information, and constructing a real-time visual guide interface; and dynamically optimizing a navigation path and a risk early warning strategy based on real-time operation feedback. The method has the following advantages and effects: a precise positioning method capable of fusing multi-scale neural features and dynamically optimizing a navigation path is provided, so that the key technical bottleneck of nerve ending visualization and real-time obstacle avoidance is solved.

Systems and methods for treating a patient's mucus hypersecretion condition are disclosed herein. Certain implementations may involve a method for reducing mucus secretion in an upper airway of a patient to treat at least one of post nasal drip or chronic cough. The method may include advancing a treatment delivery portion of an energy-based treatment device into a nostril of the patient. The treatment delivery portion may contact mucosal tissue of the upper airway without piercing the mucosal tissue. The treatment delivery portion may deliver treatment to at least one tissue selected from the group of the mucosal tissue and another tissue underlying the mucosal tissue to modify a property of the at least one tissue and thus treat at least one of post nasal drip or chronic cough in the patient.

A method of providing a channel in nervous tissue filled with an aqueous gel for implantation of a microelectrode or other medical device lacking sufficient physical stability for direct implantation by insertion, comprises providing an apparatus comprising an oblong rigid pin covered by a dry gel forming agent; locating a target in the tissue; defining a straight insertion path a desired tissue insertion point and the target; aligning the pin with its end foremost with the insertion path; inserting the pin into the tissue to a position near or at the target; allowing sufficient time to pass for a gel to be formed around the pin, withdrawing the pin. Also disclosed is a corresponding channel; a method of implantation of a microelectrode or microprobe into nervous tissue via the channel; a corresponding method of implantation of living cells; a corresponding apparatus for forming the channel.

This present disclosure provides devices, systems, and methods for the treatment of conditions pertaining to bladder control. In particular, the present disclosure provides devices, systems, and methods directed to the application of electrical stimulation to the proximal urethra and associated nervous tissue to elicit voiding contractions that normalize bladder function.

The present disclosure relates to a muscle or nerve function rehabilitation assistance device using electrically conductive hydrogel. The electrically conductive hydrogel (IT-IC) provides an electrophysiological interface function between electrically active tissues, enabling the filling of lost muscle or nerve tissue for immediate rehabilitation in the early stages. It facilitates electrophysiological signal transmission between tissues and accelerates myofiber regeneration during the recovery phase. Particularly, when the electrically conductive hydrogel (IT-IC) is applied, the transmission of electrical signals generated in the muscle can be precisely controlled by a closed-loop device capable of being feedback in conjunction with peripheral nerve stimulation and electromyogram (EMG) monitoring.

The invention belongs to the technical field of medical biological materials, and particularly relates to a repair material for trigeminal nerve injury as well as a preparation method and application of the repair material. The repairing material is prepared from the following raw materials in parts by mass: 0.5 to 5 parts of nervous tissue acellular matrix micro powder, 0.5 to 5 parts of oxidized sodium alginate, 0.005 to 0.02 part of calcium dobesilate, 0.4 to 1 part of Ca-EDTA (Ethylene Diamine Tetraacetic Acid) and 0.4 to 1 part of D-glucolactone. The repairing material is directly injected to the exposed nerve part, damaged nerves are wrapped, the protection effect is achieved, external environment irritation is prevented, the components of the repairing material have the nerve nourishing effect, repairing of the damaged nerves can be promoted, permanent injury of trigeminal nerves is avoided, the duration time of related symptoms is shortened, and the repairing material has a good application prospect. Therefore, the method has good practical application value.

The invention relates to the technical field of peripheral nerve injury suture, and particularly discloses a radio stimulation surgical suture for promoting peripheral nerve healing and a preparation method and application thereof, the radio stimulation surgical suture comprises a Mo core layer and a PLGA coating; the preparation method of the radio stimulation operation suture comprises the following steps: preparing a core layer by using metal Mo, spraying out a PLGA spinning solution through a spinning nozzle, curing in a coagulating bath to form a film, and forming a uniformly coated PLGA coating on the Mo core layer through a wet spinning technology to obtain the radio stimulation operation suture for promoting peripheral nerve healing, according to the prepared radio stimulation surgical suture, energy is obtained from an external electromagnetic field in an electromagnetic induction and capacitance coupling mode, and a stable electric field is formed on the suture and the local part of a wound, so that the electric field acts on damaged tissue. The suture can promote neuronal axon growth, Schwann cell migration and the like, and the nerve tissue regeneration efficiency is improved.

The invention belongs to the technical field of biomedical materials, and discloses a conductive composite scaffold of a bionic nerve orientation structure and a preparation method of the conductive composite scaffold of the bionic nerve orientation structure, and the conductive composite scaffold of the bionic orientation structure is formed by compounding a structural layer and a functional layer, the structural layer is an oriented nanofiber membrane (made of a natural high-molecular polymer containing amino and a synthetic high-molecular polymer), the functional layer is ionic conductive hydrogel (made of a natural high-molecular polymer containing amino and a natural high-molecular polymer containing carboxyl), and the structural layer and the functional layer are compounded through the action of an amido bond; the amido bond is formed by reacting amino of the oriented nanofiber membrane with carboxyl of the ionic conductive hydrogel under an acidic condition; the preparation method comprises the following steps: compounding the structural layer and the functional layer by using glacial acetic acid by adopting a chemical cross-linking method to prepare the conductive composite nerve scaffold with the bionic orientation structure. According to the invention, electric signal transmission between cells can be realized, and the efficiency of damaged nervous tissue repair is improved.

The invention discloses a multi-pole nerve electrical stimulation electrode catheter, and relates to the technical field of medical instruments, the multi-pole nerve electrical stimulation electrode catheter comprises a catheter body, an elastic piece, a guide wire and an electrode assembly, the catheter body is provided with a first end and a second end which are opposite, the catheter body is provided with a first channel, and the first channel extends from the first end to the second end; a closed structure is arranged at the port of the first end of the first channel; the elastic piece comprises a shaping section and has an initial state, in the initial state, the shaping section of the elastic piece is spiral in the plane, and the elastic piece is arranged in the first channel; the guide wire movably penetrates through the first channel, the guide wire can move to a limiting position or a non-limiting position, the guide wire can keep the catheter body in a linear state at the limiting position, and the elastic piece can drive the first end to be bent in a plane to be in a spiral shape at the non-limiting position; the electrode assembly is arranged on the outer side wall of the catheter body. According to the multi-pole nerve electrical stimulation electrode catheter, the opportunity of contact between the electrode and nervous tissue can be improved, and the position of the catheter is easy to fix.

The invention discloses MXene-containing conductive hydrogel and a preparation method and application thereof, the hydrogel is injectable conductive hydrogel of MXene-loaded poly-beta amino ester, and the hydrogel comprises the following raw materials: polyethylene glycol diacrylate as a support material; a molecule containing a double primary amine group as a cross-linking agent, the cross-linking agent being cross-linked with the polyethylene glycol diacrylate through an acrylate bond; the invention relates to an MXene nanosheet serving as a conductive material. The hydrogel is adjustable in mechanical property, excellent in biocompatibility and capable of being slowly released, and is used for filling nerve injury areas, simulating the electrophysiological environment of nervous tissues, promoting transmission of electric signals and promoting synaptic formation and neuronal differentiation.

The invention relates to an impedance measurement circuit and method, and belongs to the field of impedance measurement, the impedance measurement circuit comprises a plurality of measurement unit circuits and a digital-to-analog converter, the plurality of measurement unit circuits are connected in parallel, a common end of the plurality of measurement unit circuits connected in parallel is connected with a connection switch, the other end of the connection switch is connected with a current source, and the current source is grounded. The digital-to-analog converter is used for controlling the current source; the other common end of the plurality of measuring unit circuits connected in parallel is connected with a first electrode, and the other end of the first electrode is connected with a power supply end through an error switch; each measuring unit circuit comprises a measuring switch, a blocking capacitor and a second electrode which are connected in series on the same line, the measuring switch is connected with the connecting switch, the second electrode is connected with the nervous tissue, and the blocking capacitor is located between the measuring switch and the second electrode. The method has the effect of improving the impedance measurement accuracy.

This invention discloses a charge regulation circuit and related products. The charge regulation circuit is used to regulate the neutralization current during the stimulation and neutralization cycle of nerve tissue. The charge regulation circuit includes an accumulation charge storage module that stores the charge accumulated on the nerve tissue due to stimulation and neutralization, and generates a first voltage based on the accumulated charge. A first voltage acquisition module acquires the first voltage in real time during the neutralization process on the nerve tissue. A first control module outputs a first control signal in response to the first voltage meeting a first preset condition, and outputs a second control signal when the first voltage meets a second preset condition. The charge regulation module adjusts the parameters of the neutralization current on the nerve tissue according to the first or second control signal to make the charge amounts of the two oppositely polarized charges accumulated on the nerve tissue equal. This solution can achieve long-term charge balance.

Provided is the processing of a large-scale colored image dataset by efficiently performing image analysis, processing, and manipulation based on adaptive particle representation (APR). 【Solution means】The analysis of large-scale biological objects and tissue samples is performed with a calculation speed 100 times or more faster and an excellent memory storage compression ratio. The embodiment is extremely suitable for large-scale imaging projects of large three-dimensional transparent tissue samples such as whole-brain mapping initiatives and human nerve tissue pathology. The data store holds an adaptive sampling representation for tiles, individual tile positions, and other corresponding image data for the biological object of interest. By reading out a tile from the data store only once, a complete image of the maximum resolution of the biological object is output as an image.

The invention discloses a nerve cryoablation puncture needle suite with a nerve stimulation module, and relates to the technical field of medical equipment, the nerve cryoablation puncture needle suite comprises an ultrasonic easy-to-develop puncture needle main body, and the puncture needle main body is connected with a three-way valve; the probe body is connected with the needle body, the delivery pipe is arranged on the surface of the outer end of the needle body, and the other end of the delivery pipe is communicated with the three-way valve and can be used for drug delivery. After the tail end of the needle core is connected with the nerve stimulation module, current can be quantitatively output, the tip of the needle core can stimulate nerve fibers with the diameters from small to large, nerve sensation or movement reaction can be induced, focus-related nervous tissue can be accurately targeted, tissue specificity in the treatment process is ensured, and accuracy and safety of pain treatment are improved. The refrigerating pipe is arranged at the middle end in the needle body, the vacuum cavity is formed in the inner wall of the needle body, when the refrigerating fluid is vaporized and discharged through the outlet, the refrigerating fluid which is not vaporized completely makes contact with the outlet, the filler is cooled and expands to block the outlet, and the refrigerating fluid is effectively prevented from overflowing at low temperature.

1. The name of this design product: Radiofrequency trocar. 2. Purpose of the product with this design: Connect to a temperature-controlled radio frequency generator to perform radio frequency coagulation or stimulation on the patient's analgesic area through high-frequency current, loosen compressed nerve tissue and block the transmission of pain signals, so as to achieve the purpose of treating or relieving the patient's pain. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: Stereoscopic drawing 2. 5. As can be seen from the stereograms 1 and 2, the right view and bottom view are omitted.

The embodiment of the invention discloses a testing device. The testing device comprises a cable, a connecting assembly and a stimulating assembly which are connected in sequence. Wherein the connecting assembly is provided with a limiting groove for limiting and fixing the implantable electrode, a plurality of conductive elastic sheets in conductive connection with the cable are arranged in the limiting groove, and the conductive elastic sheets are used for being detachably and electrically connected with a wire of the implantable electrode, so that the implanted implantable electrode is tested. The stimulation assembly is provided with a conductive probe electrically connected with the cable, and can apply a test electric signal to the nervous tissue to carry out a stimulation reaction test, thereby assisting in accurately confirming the position of the target spot. According to the testing device, the electrode testing function and the nerve stimulation testing function are integrated into a single device, the structure is compact, operation is visual, and the accuracy, smoothness and convenience of an operation are remarkably improved.

This application belongs to the field of medical dressing technology, specifically relating to dressing compositions, absorbable hemostatic dressings, and their preparation methods. This application provides a dressing composition that, by compounding modified chitosan with modified ergothioneine, forms a dressing composition with non-swelling properties upon contact with water. The chitosan in this application is esterified to introduce hydrophilic carboxyl groups, improving its solubility. Simultaneously, aspartic acid itself promotes cell proliferation and wound healing. Therefore, the dressing prepared from this composition can maintain a stable shape and volume in a body fluid environment, effectively reducing mechanical pressure on surrounding tissues, thereby effectively avoiding various complications caused by material expansion and effectively avoiding the risk of traditional hemostatic materials swelling upon contact with water and compressing nerve tissue. Furthermore, the compounding of modified ergothioneine and modified chitosan in this application not only provides non-swelling and absorbable properties upon contact with water but also exhibits high adhesion and high antioxidant properties.

The invention discloses a system for predicting the risk of nerve injury caused by radiotherapy based on deep learning, and belongs to the technical field of medical artificial intelligence and radiotherapy, and the system comprises a neural structure automatic segmentation module, a dose-neural response modeling module, an individualized risk assessment module, a radiotherapy plan optimization module and a closed-loop feedback regulation unit. The system adopts an encoder-decoder deep network to perform high-precision segmentation on nervous tissues, establishes a dose-nerve response quantitative model by fusing dosiomics and radiomics characteristics, and realizes individualized risk assessment based on a multi-factor risk quantitative network. An optimization scheme for balancing tumor control and neuroprotection is generated through Pareto optimal search, collaborative optimization of all the modules is achieved through closed-loop feedback, and decision support is provided for precise radiotherapy.

The application provides a self-coiled flexible peripheral nerve electrode and a preparation method and application thereof, and the preparation method comprises the following steps: preparing a double-layer flexible liquid metal electrode with an exposed site; stretching the double-layer flexible liquid metal electrode, and then fixing two ends of the double-layer flexible liquid metal electrode to obtain a stretched electrode; coating a polymer prepolymer reaction solution on a surface of the stretched electrode which is opposite to the exposed site, and curing the polymer prepolymer reaction solution to form a fixing layer, so as to obtain a three-layer composite electrode; under the condition that the two ends are fixed, the fixing layer in the three-layer composite electrode faces downward, the fixing of one end of the three-layer composite electrode is released, and the three-layer composite electrode is self-coiled. The self-coiled flexible peripheral nerve electrode prepared by the preparation method of the self-coiled flexible peripheral nerve electrode has high conductivity, can realize self-coiling of the electrode, improves the detection quality and long-term stability of nerve signals, and avoids mechanical damage of nerve tissue caused by electrode implantation.

The invention discloses a mechanically controllable composite membrane material, which comprises a three-dimensional porous scaffold composed of bacterial cellulose, and bioactive ceramic nanoparticles are uniformly dispersed in and on the surface of the three-dimensional porous scaffold; the bioactive ceramic nanoparticles are one or more of tricalcium phosphate, bioactive glass, calcium silicate and hydroxyapatite. According to the invention, the bioactive ceramic nanoparticles are uniformly loaded inside and on the surface of the three-dimensional porous scaffold formed by bacterial cellulose, and the composite membrane material can be endowed with a unique biological function by adjusting the types of the bioactive ceramic nanoparticles. The composite membrane material prepared by an in-situ, ectopic or chemical deposition method and the like can realize synergy and balance of mechanical properties and biological functions, and the structural design of the composite membrane material provides necessary mechanical support and also gives consideration to flexible fit with fragile nervous tissues, so that the composite membrane material has a wide application prospect in the field of neurosurgery.

The invention relates to a spine intervertebral dilator which comprises a main support, a fixed supporting arm, a sliding supporting arm, a distraction blade and a control module, a biological impedance sensor array is integrated on the working surface of the distraction blade, and the biological impedance sensor array conducts real-time induction at the moment of touching nerve roots by detecting the electrophysiological characteristic difference of contact tissue; the control module receives impedance data of the biological impedance sensor array in real time, and when the biological impedance sensor array detects an impedance threshold value, the self-locking alarm module is triggered immediately and is self-locked; according to the spine intervertebral dilator, tissue electrophysiological characteristic differences are detected in real time through the integrated biological impedance sensor array, accurate recognition of nervous tissues is achieved in combination with multi-sensor fusion and a deep learning algorithm, a self-locking mechanism is triggered immediately when nerve roots are touched, and the spine intervertebral dilator is used for distraction of the nerve roots. The device has the advantages that nervous tissue is accurately recognized, real-time self-locking protection is achieved, and the risk of nerve injury in the operation is reduced.

The invention discloses an image display method, system and device and a storage medium, and the method comprises the steps: correcting a second medical image obtained in an operation preparation stage through a first medical image collected in a preoperative stage, obtaining a third medical image of a specified focus part in the operation preparation stage, and displaying the third medical image. And in response to a selection operation performed on the third medical image by the user, determining an initial operation image region for the to-be-processed bone tissue in the third medical image, further adjusting the initial operation image region according to an image region where a nervous tissue in the soft tissue in the third medical image is located, and determining and displaying an actual operative image region. The second medical image is corrected through the first medical image, and then the initial operation image area is adjusted through the image area where the nervous tissue in the soft tissue in the obtained third medical image is located, so that the actual operation image area which is used for the bone grinding operation process and can avoid damage to the nervous tissue is obtained.

Tissue-processing containers are disclosed for facilitating multistep processing of tissue. Also disclosed are systems incorporating the tissue-processing containers that include shakers, incubators, controllers, and pumps. Multistep methods are disclosed for processing tissues using the tissue-processing containers. The tissue-processing containers are specially designed to achieve efficiencies in automated tissue processing, exposure of tissues to processing media, and multistep tissue processing protocols. The described tissue-processing containers comprise a cup-like cavity comprising a middle hole covered by a mesh screen, troughs for separate processing steps, and are stackable in a substantially airtight and substantially watertight manner. Tissues for processing using the described tissue-processing containers include nerve tissue. Also described herein is a transport housing for the transport of stacks of tissue-processing containers, and which may directly incubate those containers, or which may be placed inside a separate incubator for incubating the containers.

The invention discloses a modified gelatin liquid metal biomedical nerve adhesive and a preparation method thereof, belongs to the technical field of biomedical materials, and aims at solving the technical problems that an existing nerve tissue adhesive is low in adhesion strength, lack of conductivity and the like. According to the method, gelatin is used as a biocompatible matrix, and the reaction activity of the gelatin is improved through amination modification; lipoic acid is used as a main cross-linking component, a controllable polymer network structure is constructed by using the thermal initiation ring-opening polymerization characteristic of the lipoic acid, and tannic acid is used as a cross-linking agent to assist in regulating and controlling the pre-reaction degree; meanwhile, by adopting a mode of coating the liquid metal nanoparticles with tannic acid, the material is endowed with good conductivity, and the combination of the liquid metal and the organic matrix is enhanced at the same time. By accurately controlling the pre-reaction and deep polymerization process, the obtained adhesive has good histocompatibility and neural signal transduction capability, and has potential application value in the fields of nervous tissue repair and regeneration.

The application discloses a handle type intelligent puncture instrument for intravertebral anesthesia, which comprises a shell, an anesthesia needle, a guide needle and a data processor, a fixing block for fixing the insertion end of the anesthesia needle is arranged at the front end of the shell, a base is fixed in the shell, a reverse L-shaped support is fixed at the front end of the base, a lead screw is arranged at the side of the reverse L-shaped support, a servo motor is arranged on the lead screw, a long slot is arranged on the reverse L-shaped support, the top of the servo motor passes through the slot and is sequentially connected with a first U-shaped clamping groove and a second U-shaped clamping groove which are respectively used for fixing the tail end of the anesthesia needle and the tail end of the guide needle, a ring-shaped pressure sensor is arranged in each of the first U-shaped clamping groove and the second U-shaped clamping groove, and the ring-shaped pressure sensor is connected with the data processor through a wire. The application has the advantages of reasonable design, convenient use, effective reduction of puncture difficulty, improvement of puncture success rate, real-time reflection of the needle insertion depth in the puncture process, avoidance of the risk of damaging nerve tissues, stable adsorption and improvement of work efficiency.

The utility model relates to the technical field of medical instruments, in particular to a nerve detacher which comprises a handle and a detacher body. The two ends of the stripper body are a fixed end and a stripping end respectively, the fixed end is fixedly installed on the handle, a negative pressure channel is arranged in the stripper body and provided with two inlets, the two inlets of the negative pressure channel are a first adsorption port and a second adsorption port respectively, the first adsorption port is located on one side of the stripping end, and the second adsorption port is located on the other side of the stripping end. The second adsorption port is located on the other side of the stripping end. According to the nerve detacher, the negative pressure channel is formed in the detacher body, so that the detacher body integrates the functions of detaching the nervous tissue and adsorbing the to-be-cleaned object, a doctor does not need to alternately use various tools, the to-be-cleaned object can be directly adsorbed after related operations are completed, tool replacement is reduced, and the operation is smoother and more efficient. In a complex operation, frequent tool replacement can be avoided, and pause and preparation time is shortened.

A system and method can be used to denervate at least a portion of a bronchial tree. An energy emitter of an instrument is percutaneously delivered to a treatment site and outputs energy to damage nerve tissue of the bronchial tree. The denervation procedure can be performed without damaging non-targeted tissue. Minimally invasive methods can be used to open airways to improve lung function in subjects with COPD, asthma, or the like. Different sections of the bronchial tree can be denervated while leaving airways intact to reduce recovery times.

Methods and pharmaceutical compositions are provided, which make use of compounds disclosed herein, including (I). The methods and compositions are useful for producing local or regional anesthesia or analgesia in nerve tissue of a subject.

An implantable electrode device is provided comprising a first layer and a second layer, the second layer being on top of the first layer and including at least one electrode contact. The at least one electrode contact is exposable to a nerve of a nervous tissue of a human or of an animal. A connecting means electrically connects the electrode contact, where the connecting means is made up of at least one conducting wire, and the conducting wire is arranged within the first layer and is fixed to the electrode contact. Also provided is a method for forming an implantable electrode device.