192 results about "Nerves tissue" patented technology

The invention relates to the technical field of medical instruments, and provides electric coagulation forceps with an intraoperative nerve detection function and a control method for the electric coagulation forceps to automatically switch a nerve stimulation function and an electric coagulation function, and the electric coagulation forceps comprise a high-frequency excitation identification circuit, a controller and a nerve monitoring switching circuit. The high-frequency excitation identification circuit is used for generating a corresponding induction signal according to whether the high-frequency excitation signal is detected; the controller generates a first control signal, starts timing and determines target delay time after determining that the electrocoagulation cutting function of the pair of electrocoagulation forceps is converted from an on state to an off state according to the induction signal, and generates a first prompt signal to indicate the prompt device to generate first prompt information after the timing time reaches the target delay time; the user is prompted; the nerve monitoring switching circuit is used for responding to the first control signal and outputting a nerve stimulation signal of the nerve monitor through the forceps tips, so that the nerve tissue damage probability is reduced while automatic function switching is achieved.

The invention discloses an electrical stimulation type nerve regeneration method based on calcium signal regulation and control, and relates to the technical field of electrical stimulation type nerve regeneration, and the method comprises the following steps: based on a Schwann cell population calcium signal response feature set, identifying whether the calcium ion concentration is in a microliter stage which breaks through a lowest activation threshold and does not reach a stable state; judging whether the target nervous tissue is in a calcium signal activation critical state or not based on the behavior mode change of the Schwann cell population; based on the judgment result of the calcium signal activation critical state, an electrical stimulation adjustment control instruction is generated in real time in combination with the calcium ion concentration fluctuation trend and Schwann cell population response characteristics, and the calcium ion concentration stability is optimized and the activation state is maintained by adjusting the electrical stimulation intensity, the electrical stimulation pulse width, the electrical stimulation waveform type and the electrical stimulation application time sequence. According to the method, the problem that a calcium signal is difficult to recognize and dynamically optimize in a microliter stage is solved, and precise maintenance of Schwann cell activation and improvement of nerve regeneration efficiency are realized.

The utility model relates to the technical field of medical equipment, in particular to an electric coagulation forceps device with a nerve electrophysiology monitoring function and a function gating circuit, and the gating circuit comprises a main control module, a gating control module, an electrophysiology stimulation module, an electrophysiology monitoring module and an electric coagulation generation module. The main control module is used for receiving a switching signal input by a user and generating a gating enable signal corresponding to the switching signal; and the gating control module is used for generating a working enable signal corresponding to the gating enable signal so as to control at least one of the electrophysiological stimulation module, the electrophysiological monitoring module and the electrocoagulation generation module to work. In the operation process, if a doctor selects the electrophysiological stimulation module, the electrophysiological stimulation module can electrically stimulate nervous tissue according to a working enable signal, so that nerves can transmit an electrophysiological signal sufficient to be monitored; and then the electrophysiology monitoring module carries out intraoperative electrophysiology signal monitoring on the nervous tissue so as to detect whether the nerves are damaged or not.

The invention discloses an anesthesia nerve precise positioning method and system based on ultrasonic image auxiliary processing, and the method comprises the following steps: obtaining a real-time dynamic ultrasonic image sequence of a target region through an ultrasonic image data collection device, carrying out the multi-modal data fusion processing, and generating an enhanced ultrasonic image data set; performing three-dimensional semantic segmentation on the enhanced ultrasonic image data set based on a preset anesthesia nerve region segmentation model, and extracting morphological characteristics and spatial distribution information of a target nerve tissue; generating a three-dimensional navigation path grid based on the extracted morphological characteristics and spatial distribution information, and constructing a real-time visual guide interface; and dynamically optimizing a navigation path and a risk early warning strategy based on real-time operation feedback. The method has the following advantages and effects: a precise positioning method capable of fusing multi-scale neural features and dynamically optimizing a navigation path is provided, so that the key technical bottleneck of nerve ending visualization and real-time obstacle avoidance is solved.

Systems and methods for treating a patient's mucus hypersecretion condition are disclosed herein. Certain implementations may involve a method for reducing mucus secretion in an upper airway of a patient to treat at least one of post nasal drip or chronic cough. The method may include advancing a treatment delivery portion of an energy-based treatment device into a nostril of the patient. The treatment delivery portion may contact mucosal tissue of the upper airway without piercing the mucosal tissue. The treatment delivery portion may deliver treatment to at least one tissue selected from the group of the mucosal tissue and another tissue underlying the mucosal tissue to modify a property of the at least one tissue and thus treat at least one of post nasal drip or chronic cough in the patient.

A method of providing a channel in nervous tissue filled with an aqueous gel for implantation of a microelectrode or other medical device lacking sufficient physical stability for direct implantation by insertion, comprises providing an apparatus comprising an oblong rigid pin covered by a dry gel forming agent; locating a target in the tissue; defining a straight insertion path a desired tissue insertion point and the target; aligning the pin with its end foremost with the insertion path; inserting the pin into the tissue to a position near or at the target; allowing sufficient time to pass for a gel to be formed around the pin, withdrawing the pin. Also disclosed is a corresponding channel; a method of implantation of a microelectrode or microprobe into nervous tissue via the channel; a corresponding method of implantation of living cells; a corresponding apparatus for forming the channel.

This present disclosure provides devices, systems, and methods for the treatment of conditions pertaining to bladder control. In particular, the present disclosure provides devices, systems, and methods directed to the application of electrical stimulation to the proximal urethra and associated nervous tissue to elicit voiding contractions that normalize bladder function.

A device may obtain imaging data. The imaging data that is obtained depicts one or more body parts of a patient. A voltage sensitive dye may be applied to stain nerve tissue associated with the one or more body parts of the patient. The voltage sensitive dye may be activated by neuromodulation applied to stimulate the nerve tissue. The imaging data may capture a fluorescence of the nerve tissue based on the voltage sensitive dye being activated by neuromodulation. The device may provide the imaging data for display.

The present disclosure relates to a muscle or nerve function rehabilitation assistance device using electrically conductive hydrogel. The electrically conductive hydrogel (IT-IC) provides an electrophysiological interface function between electrically active tissues, enabling the filling of lost muscle or nerve tissue for immediate rehabilitation in the early stages. It facilitates electrophysiological signal transmission between tissues and accelerates myofiber regeneration during the recovery phase. Particularly, when the electrically conductive hydrogel (IT-IC) is applied, the transmission of electrical signals generated in the muscle can be precisely controlled by a closed-loop device capable of being feedback in conjunction with peripheral nerve stimulation and electromyogram (EMG) monitoring.

The invention belongs to the technical field of medical biological materials, and particularly relates to a repair material for trigeminal nerve injury as well as a preparation method and application of the repair material. The repairing material is prepared from the following raw materials in parts by mass: 0.5 to 5 parts of nervous tissue acellular matrix micro powder, 0.5 to 5 parts of oxidized sodium alginate, 0.005 to 0.02 part of calcium dobesilate, 0.4 to 1 part of Ca-EDTA (Ethylene Diamine Tetraacetic Acid) and 0.4 to 1 part of D-glucolactone. The repairing material is directly injected to the exposed nerve part, damaged nerves are wrapped, the protection effect is achieved, external environment irritation is prevented, the components of the repairing material have the nerve nourishing effect, repairing of the damaged nerves can be promoted, permanent injury of trigeminal nerves is avoided, the duration time of related symptoms is shortened, and the repairing material has a good application prospect. Therefore, the method has good practical application value.

To achieve in vivo repair of severed mammalian nerve tissue, a system can be employed to induce distraction neurogenesis. At least a portion of the system can be anchored at an injury site, such as between distal and proximal nerve ends. The system can be attached to the proximal nerve end and can place the nerve under micro-tension for an extended period of treatment. The system may also deliver medication or treatment to encourage neurogenesis and to reduce pain in the subject receiving treatment. After the course of treatment, the device can be removed from the injury site, and the nerve ends rejoined.

The invention relates to the technical field of peripheral nerve injury suture, and particularly discloses a radio stimulation surgical suture for promoting peripheral nerve healing and a preparation method and application thereof, the radio stimulation surgical suture comprises a Mo core layer and a PLGA coating; the preparation method of the radio stimulation operation suture comprises the following steps: preparing a core layer by using metal Mo, spraying out a PLGA spinning solution through a spinning nozzle, curing in a coagulating bath to form a film, and forming a uniformly coated PLGA coating on the Mo core layer through a wet spinning technology to obtain the radio stimulation operation suture for promoting peripheral nerve healing, according to the prepared radio stimulation surgical suture, energy is obtained from an external electromagnetic field in an electromagnetic induction and capacitance coupling mode, and a stable electric field is formed on the suture and the local part of a wound, so that the electric field acts on damaged tissue. The suture can promote neuronal axon growth, Schwann cell migration and the like, and the nerve tissue regeneration efficiency is improved.

The invention belongs to the technical field of biomedical materials, and discloses a conductive composite scaffold of a bionic nerve orientation structure and a preparation method of the conductive composite scaffold of the bionic nerve orientation structure, and the conductive composite scaffold of the bionic orientation structure is formed by compounding a structural layer and a functional layer, the structural layer is an oriented nanofiber membrane (made of a natural high-molecular polymer containing amino and a synthetic high-molecular polymer), the functional layer is ionic conductive hydrogel (made of a natural high-molecular polymer containing amino and a natural high-molecular polymer containing carboxyl), and the structural layer and the functional layer are compounded through the action of an amido bond; the amido bond is formed by reacting amino of the oriented nanofiber membrane with carboxyl of the ionic conductive hydrogel under an acidic condition; the preparation method comprises the following steps: compounding the structural layer and the functional layer by using glacial acetic acid by adopting a chemical cross-linking method to prepare the conductive composite nerve scaffold with the bionic orientation structure. According to the invention, electric signal transmission between cells can be realized, and the efficiency of damaged nervous tissue repair is improved.

The invention discloses a multi-pole nerve electrical stimulation electrode catheter, and relates to the technical field of medical instruments, the multi-pole nerve electrical stimulation electrode catheter comprises a catheter body, an elastic piece, a guide wire and an electrode assembly, the catheter body is provided with a first end and a second end which are opposite, the catheter body is provided with a first channel, and the first channel extends from the first end to the second end; a closed structure is arranged at the port of the first end of the first channel; the elastic piece comprises a shaping section and has an initial state, in the initial state, the shaping section of the elastic piece is spiral in the plane, and the elastic piece is arranged in the first channel; the guide wire movably penetrates through the first channel, the guide wire can move to a limiting position or a non-limiting position, the guide wire can keep the catheter body in a linear state at the limiting position, and the elastic piece can drive the first end to be bent in a plane to be in a spiral shape at the non-limiting position; the electrode assembly is arranged on the outer side wall of the catheter body. According to the multi-pole nerve electrical stimulation electrode catheter, the opportunity of contact between the electrode and nervous tissue can be improved, and the position of the catheter is easy to fix.

The invention provides a nerve sheathing canal and a preparation method and application thereof, and belongs to the technical field of biomedical material development. According to the nerve sheathing canal provided by the invention, the problem of limited mechanical properties of related materials in the prior art is solved by optimizing the materials and the preparation method. The nerve sheathing canal disclosed by the invention has multiple remarkable advantages that the biocompatibility is excellent, and the nerve sheathing canal is highly compatible with human tissues; the auxiliary agent residue in the processing process is extremely small, so that the biological safety of the product is ensured; the nerve sheathing canal has good flexibility, so that the surgical operation is facilitated, and the surrounding tissues are prevented from being clamped and pressed after the nerve sheathing canal is implanted; due to the addition of graphene, the nerve sheathing canal shows electroactivity, and a new way is provided for nerve tissue repair and function detection. Due to the characteristics, the nerve sheathing canal has a wide application prospect in the field of biomedicine.

An example system includes processing circuitry; and an endovascular device includes an expandable substrate configured to be delivered endovascularly to a trial therapy delivery location in a patient; one or more first electrodes positioned on the expandable substrate, wherein the one or more first electrodes are configured to deliver nerve tissue stimulation trial therapy to a target nerve tissue of the patient; and one or more second electrodes positioned on the expandable substrate, wherein the one or more second electrodes are configured to sense one or more activation signals of the target nerve tissue, wherein the processing circuitry is configured to determine whether activation of the target nerve tissue at the trial therapy delivery location satisfies a target nerve tissue activation threshold based on the one or more sensed activation signals.

The invention discloses MXene-containing conductive hydrogel and a preparation method and application thereof, the hydrogel is injectable conductive hydrogel of MXene-loaded poly-beta amino ester, and the hydrogel comprises the following raw materials: polyethylene glycol diacrylate as a support material; a molecule containing a double primary amine group as a cross-linking agent, the cross-linking agent being cross-linked with the polyethylene glycol diacrylate through an acrylate bond; the invention relates to an MXene nanosheet serving as a conductive material. The hydrogel is adjustable in mechanical property, excellent in biocompatibility and capable of being slowly released, and is used for filling nerve injury areas, simulating the electrophysiological environment of nervous tissues, promoting transmission of electric signals and promoting synaptic formation and neuronal differentiation.

The invention relates to an impedance measurement circuit and method, and belongs to the field of impedance measurement, the impedance measurement circuit comprises a plurality of measurement unit circuits and a digital-to-analog converter, the plurality of measurement unit circuits are connected in parallel, a common end of the plurality of measurement unit circuits connected in parallel is connected with a connection switch, the other end of the connection switch is connected with a current source, and the current source is grounded. The digital-to-analog converter is used for controlling the current source; the other common end of the plurality of measuring unit circuits connected in parallel is connected with a first electrode, and the other end of the first electrode is connected with a power supply end through an error switch; each measuring unit circuit comprises a measuring switch, a blocking capacitor and a second electrode which are connected in series on the same line, the measuring switch is connected with the connecting switch, the second electrode is connected with the nervous tissue, and the blocking capacitor is located between the measuring switch and the second electrode. The method has the effect of improving the impedance measurement accuracy.

This invention discloses a charge regulation circuit and related products. The charge regulation circuit is used to regulate the neutralization current during the stimulation and neutralization cycle of nerve tissue. The charge regulation circuit includes an accumulation charge storage module that stores the charge accumulated on the nerve tissue due to stimulation and neutralization, and generates a first voltage based on the accumulated charge. A first voltage acquisition module acquires the first voltage in real time during the neutralization process on the nerve tissue. A first control module outputs a first control signal in response to the first voltage meeting a first preset condition, and outputs a second control signal when the first voltage meets a second preset condition. The charge regulation module adjusts the parameters of the neutralization current on the nerve tissue according to the first or second control signal to make the charge amounts of the two oppositely polarized charges accumulated on the nerve tissue equal. This solution can achieve long-term charge balance.

The utility model discloses a puncture surgical instrument device. The injection needle comprises a needle body, a needle sleeve is fixedly arranged on the outer side of the needle body, an injection hole and a laser optical fiber are arranged in the needle body, one end of the needle body is exposed out of the needle sleeve, and an optical fiber connector module is detachably and fixedly arranged at the other end of the needle body; the outer side of the needle body is electrically connected with equipment for generating current, and the laser optical fiber is electrically connected with the optical fiber connector module; a target tissue is electrically stimulated through the needle body, a nervous tissue is positioned, a target tissue inducing tumor pain is accurately found, after the target tissue is found, laser ablation is conducted on the target tissue by placing a laser optical fiber through a mounting hole, and finally, when medicine injection and water separation release need to be conducted on the target tissue, the target tissue is subjected to laser ablation. The liquid medicine can be conveyed to a target tissue through the injection hole; tedious operations such as repeated puncture injury and replacement of puncture needles are avoided, the possibility of tumor metastasis caused by surgical operation can be reduced while the surgical time is shortened, and original nerves are protected to the maximum extent.

Provided is the processing of a large-scale colored image dataset by efficiently performing image analysis, processing, and manipulation based on adaptive particle representation (APR). 【Solution means】The analysis of large-scale biological objects and tissue samples is performed with a calculation speed 100 times or more faster and an excellent memory storage compression ratio. The embodiment is extremely suitable for large-scale imaging projects of large three-dimensional transparent tissue samples such as whole-brain mapping initiatives and human nerve tissue pathology. The data store holds an adaptive sampling representation for tiles, individual tile positions, and other corresponding image data for the biological object of interest. By reading out a tile from the data store only once, a complete image of the maximum resolution of the biological object is output as an image.

The invention discloses a nerve cryoablation puncture needle suite with a nerve stimulation module, and relates to the technical field of medical equipment, the nerve cryoablation puncture needle suite comprises an ultrasonic easy-to-develop puncture needle main body, and the puncture needle main body is connected with a three-way valve; the probe body is connected with the needle body, the delivery pipe is arranged on the surface of the outer end of the needle body, and the other end of the delivery pipe is communicated with the three-way valve and can be used for drug delivery. After the tail end of the needle core is connected with the nerve stimulation module, current can be quantitatively output, the tip of the needle core can stimulate nerve fibers with the diameters from small to large, nerve sensation or movement reaction can be induced, focus-related nervous tissue can be accurately targeted, tissue specificity in the treatment process is ensured, and accuracy and safety of pain treatment are improved. The refrigerating pipe is arranged at the middle end in the needle body, the vacuum cavity is formed in the inner wall of the needle body, when the refrigerating fluid is vaporized and discharged through the outlet, the refrigerating fluid which is not vaporized completely makes contact with the outlet, the filler is cooled and expands to block the outlet, and the refrigerating fluid is effectively prevented from overflowing at low temperature.

1. The name of this design product: Radiofrequency trocar. 2. Purpose of the product with this design: Connect to a temperature-controlled radio frequency generator to perform radio frequency coagulation or stimulation on the patient's analgesic area through high-frequency current, loosen compressed nerve tissue and block the transmission of pain signals, so as to achieve the purpose of treating or relieving the patient's pain. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: Stereoscopic drawing 2. 5. As can be seen from the stereograms 1 and 2, the right view and bottom view are omitted.

Provided is a device and a method of assessing anatomy and nerve health, which may include using impedance measurements to distinguish tissue types, locate damaged nerve tissue, and provide information regarding the health of nerve tissue

The embodiment of the invention discloses a testing device. The testing device comprises a cable, a connecting assembly and a stimulating assembly which are connected in sequence. Wherein the connecting assembly is provided with a limiting groove for limiting and fixing the implantable electrode, a plurality of conductive elastic sheets in conductive connection with the cable are arranged in the limiting groove, and the conductive elastic sheets are used for being detachably and electrically connected with a wire of the implantable electrode, so that the implanted implantable electrode is tested. The stimulation assembly is provided with a conductive probe electrically connected with the cable, and can apply a test electric signal to the nervous tissue to carry out a stimulation reaction test, thereby assisting in accurately confirming the position of the target spot. According to the testing device, the electrode testing function and the nerve stimulation testing function are integrated into a single device, the structure is compact, operation is visual, and the accuracy, smoothness and convenience of an operation are remarkably improved.

Systems, devices, and techniques are described for calibrating a medical device that senses ECAP signals from a patient's nerve tissue. For example a method includes instructing, with processing circuitry, stimulation circuitry of a medical device to deliver, on stimulation electrodes of the medical device, an electrical stimulation signal having an amplitude substantially equal to zero to a patient, entering, with the processing circuitry subsequent to instructing the stimulation circuitry to deliver the electrical stimulation signal, a passive recharge state on stimulation electrode circuitry, and auto-zeroing, with the processing circuitry, inputs to an operational amplifier of sensing circuitry electrically coupled to sensing electrodes of the medical device while the stimulation electrode circuitry is in the passive recharge state.

This application belongs to the field of medical dressing technology, specifically relating to dressing compositions, absorbable hemostatic dressings, and their preparation methods. This application provides a dressing composition that, by compounding modified chitosan with modified ergothioneine, forms a dressing composition with non-swelling properties upon contact with water. The chitosan in this application is esterified to introduce hydrophilic carboxyl groups, improving its solubility. Simultaneously, aspartic acid itself promotes cell proliferation and wound healing. Therefore, the dressing prepared from this composition can maintain a stable shape and volume in a body fluid environment, effectively reducing mechanical pressure on surrounding tissues, thereby effectively avoiding various complications caused by material expansion and effectively avoiding the risk of traditional hemostatic materials swelling upon contact with water and compressing nerve tissue. Furthermore, the compounding of modified ergothioneine and modified chitosan in this application not only provides non-swelling and absorbable properties upon contact with water but also exhibits high adhesion and high antioxidant properties.

The invention discloses a system for predicting the risk of nerve injury caused by radiotherapy based on deep learning, and belongs to the technical field of medical artificial intelligence and radiotherapy, and the system comprises a neural structure automatic segmentation module, a dose-neural response modeling module, an individualized risk assessment module, a radiotherapy plan optimization module and a closed-loop feedback regulation unit. The system adopts an encoder-decoder deep network to perform high-precision segmentation on nervous tissues, establishes a dose-nerve response quantitative model by fusing dosiomics and radiomics characteristics, and realizes individualized risk assessment based on a multi-factor risk quantitative network. An optimization scheme for balancing tumor control and neuroprotection is generated through Pareto optimal search, collaborative optimization of all the modules is achieved through closed-loop feedback, and decision support is provided for precise radiotherapy.

The invention provides an artificial limb control method and system. The artificial limb control method comprises the steps that sensory feedback information is acquired, and a stimulation signal is generated according to the sensory feedback information; wherein the sensory feedback information refers to state information of the artificial limb in a first contact state after the artificial limb is in contact with an external object, the stimulation signal is used for stimulating stress tissue of the amputee, and the stress tissue comprises muscular tissue or nervous tissue corresponding to the artificial limb; obtaining stress information generated after the stress tissue receives the stimulation signal; and generating a control signal according to the stress information, wherein the control signal is used for dynamically controlling the artificial limb and the external object to be switched from the first contact state to the second contact state. The contact state of the artificial limb and an external object is coordinated and corrected based on the sensory feedback information, the accurate control degree and the flexible coordination of the artificial limb are improved, the optimal adaptability is achieved, and the autonomous purpose of the amputee is achieved.

The application provides a self-coiled flexible peripheral nerve electrode and a preparation method and application thereof, and the preparation method comprises the following steps: preparing a double-layer flexible liquid metal electrode with an exposed site; stretching the double-layer flexible liquid metal electrode, and then fixing two ends of the double-layer flexible liquid metal electrode to obtain a stretched electrode; coating a polymer prepolymer reaction solution on a surface of the stretched electrode which is opposite to the exposed site, and curing the polymer prepolymer reaction solution to form a fixing layer, so as to obtain a three-layer composite electrode; under the condition that the two ends are fixed, the fixing layer in the three-layer composite electrode faces downward, the fixing of one end of the three-layer composite electrode is released, and the three-layer composite electrode is self-coiled. The self-coiled flexible peripheral nerve electrode prepared by the preparation method of the self-coiled flexible peripheral nerve electrode has high conductivity, can realize self-coiling of the electrode, improves the detection quality and long-term stability of nerve signals, and avoids mechanical damage of nerve tissue caused by electrode implantation.