122 results about "Nerves tissue" patented technology

The invention discloses an electrical stimulation type nerve regeneration method based on calcium signal regulation and control, and relates to the technical field of electrical stimulation type nerve regeneration, and the method comprises the following steps: based on a Schwann cell population calcium signal response feature set, identifying whether the calcium ion concentration is in a microliter stage which breaks through a lowest activation threshold and does not reach a stable state; judging whether the target nervous tissue is in a calcium signal activation critical state or not based on the behavior mode change of the Schwann cell population; based on the judgment result of the calcium signal activation critical state, an electrical stimulation adjustment control instruction is generated in real time in combination with the calcium ion concentration fluctuation trend and Schwann cell population response characteristics, and the calcium ion concentration stability is optimized and the activation state is maintained by adjusting the electrical stimulation intensity, the electrical stimulation pulse width, the electrical stimulation waveform type and the electrical stimulation application time sequence. According to the method, the problem that a calcium signal is difficult to recognize and dynamically optimize in a microliter stage is solved, and precise maintenance of Schwann cell activation and improvement of nerve regeneration efficiency are realized.

The invention discloses an anesthesia nerve precise positioning method and system based on ultrasonic image auxiliary processing, and the method comprises the following steps: obtaining a real-time dynamic ultrasonic image sequence of a target region through an ultrasonic image data collection device, carrying out the multi-modal data fusion processing, and generating an enhanced ultrasonic image data set; performing three-dimensional semantic segmentation on the enhanced ultrasonic image data set based on a preset anesthesia nerve region segmentation model, and extracting morphological characteristics and spatial distribution information of a target nerve tissue; generating a three-dimensional navigation path grid based on the extracted morphological characteristics and spatial distribution information, and constructing a real-time visual guide interface; and dynamically optimizing a navigation path and a risk early warning strategy based on real-time operation feedback. The method has the following advantages and effects: a precise positioning method capable of fusing multi-scale neural features and dynamically optimizing a navigation path is provided, so that the key technical bottleneck of nerve ending visualization and real-time obstacle avoidance is solved.

A method of providing a channel in nervous tissue filled with an aqueous gel for implantation of a microelectrode or other medical device lacking sufficient physical stability for direct implantation by insertion, comprises providing an apparatus comprising an oblong rigid pin covered by a dry gel forming agent; locating a target in the tissue; defining a straight insertion path a desired tissue insertion point and the target; aligning the pin with its end foremost with the insertion path; inserting the pin into the tissue to a position near or at the target; allowing sufficient time to pass for a gel to be formed around the pin, withdrawing the pin. Also disclosed is a corresponding channel; a method of implantation of a microelectrode or microprobe into nervous tissue via the channel; a corresponding method of implantation of living cells; a corresponding apparatus for forming the channel.

The invention belongs to the technical field of medical biological materials, and particularly relates to a repair material for trigeminal nerve injury as well as a preparation method and application of the repair material. The repairing material is prepared from the following raw materials in parts by mass: 0.5 to 5 parts of nervous tissue acellular matrix micro powder, 0.5 to 5 parts of oxidized sodium alginate, 0.005 to 0.02 part of calcium dobesilate, 0.4 to 1 part of Ca-EDTA (Ethylene Diamine Tetraacetic Acid) and 0.4 to 1 part of D-glucolactone. The repairing material is directly injected to the exposed nerve part, damaged nerves are wrapped, the protection effect is achieved, external environment irritation is prevented, the components of the repairing material have the nerve nourishing effect, repairing of the damaged nerves can be promoted, permanent injury of trigeminal nerves is avoided, the duration time of related symptoms is shortened, and the repairing material has a good application prospect. Therefore, the method has good practical application value.

The invention belongs to the technical field of biomedical materials, and discloses a conductive composite scaffold of a bionic nerve orientation structure and a preparation method of the conductive composite scaffold of the bionic nerve orientation structure, and the conductive composite scaffold of the bionic orientation structure is formed by compounding a structural layer and a functional layer, the structural layer is an oriented nanofiber membrane (made of a natural high-molecular polymer containing amino and a synthetic high-molecular polymer), the functional layer is ionic conductive hydrogel (made of a natural high-molecular polymer containing amino and a natural high-molecular polymer containing carboxyl), and the structural layer and the functional layer are compounded through the action of an amido bond; the amido bond is formed by reacting amino of the oriented nanofiber membrane with carboxyl of the ionic conductive hydrogel under an acidic condition; the preparation method comprises the following steps: compounding the structural layer and the functional layer by using glacial acetic acid by adopting a chemical cross-linking method to prepare the conductive composite nerve scaffold with the bionic orientation structure. According to the invention, electric signal transmission between cells can be realized, and the efficiency of damaged nervous tissue repair is improved.

The invention discloses MXene-containing conductive hydrogel and a preparation method and application thereof, the hydrogel is injectable conductive hydrogel of MXene-loaded poly-beta amino ester, and the hydrogel comprises the following raw materials: polyethylene glycol diacrylate as a support material; a molecule containing a double primary amine group as a cross-linking agent, the cross-linking agent being cross-linked with the polyethylene glycol diacrylate through an acrylate bond; the invention relates to an MXene nanosheet serving as a conductive material. The hydrogel is adjustable in mechanical property, excellent in biocompatibility and capable of being slowly released, and is used for filling nerve injury areas, simulating the electrophysiological environment of nervous tissues, promoting transmission of electric signals and promoting synaptic formation and neuronal differentiation.

This invention discloses a charge regulation circuit and related products. The charge regulation circuit is used to regulate the neutralization current during the stimulation and neutralization cycle of nerve tissue. The charge regulation circuit includes an accumulation charge storage module that stores the charge accumulated on the nerve tissue due to stimulation and neutralization, and generates a first voltage based on the accumulated charge. A first voltage acquisition module acquires the first voltage in real time during the neutralization process on the nerve tissue. A first control module outputs a first control signal in response to the first voltage meeting a first preset condition, and outputs a second control signal when the first voltage meets a second preset condition. The charge regulation module adjusts the parameters of the neutralization current on the nerve tissue according to the first or second control signal to make the charge amounts of the two oppositely polarized charges accumulated on the nerve tissue equal. This solution can achieve long-term charge balance.

1. The name of this design product: Radiofrequency trocar. 2. Purpose of the product with this design: Connect to a temperature-controlled radio frequency generator to perform radio frequency coagulation or stimulation on the patient's analgesic area through high-frequency current, loosen compressed nerve tissue and block the transmission of pain signals, so as to achieve the purpose of treating or relieving the patient's pain. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: Stereoscopic drawing 2. 5. As can be seen from the stereograms 1 and 2, the right view and bottom view are omitted.

The embodiment of the invention discloses a testing device. The testing device comprises a cable, a connecting assembly and a stimulating assembly which are connected in sequence. Wherein the connecting assembly is provided with a limiting groove for limiting and fixing the implantable electrode, a plurality of conductive elastic sheets in conductive connection with the cable are arranged in the limiting groove, and the conductive elastic sheets are used for being detachably and electrically connected with a wire of the implantable electrode, so that the implanted implantable electrode is tested. The stimulation assembly is provided with a conductive probe electrically connected with the cable, and can apply a test electric signal to the nervous tissue to carry out a stimulation reaction test, thereby assisting in accurately confirming the position of the target spot. According to the testing device, the electrode testing function and the nerve stimulation testing function are integrated into a single device, the structure is compact, operation is visual, and the accuracy, smoothness and convenience of an operation are remarkably improved.

This application belongs to the field of medical dressing technology, specifically relating to dressing compositions, absorbable hemostatic dressings, and their preparation methods. This application provides a dressing composition that, by compounding modified chitosan with modified ergothioneine, forms a dressing composition with non-swelling properties upon contact with water. The chitosan in this application is esterified to introduce hydrophilic carboxyl groups, improving its solubility. Simultaneously, aspartic acid itself promotes cell proliferation and wound healing. Therefore, the dressing prepared from this composition can maintain a stable shape and volume in a body fluid environment, effectively reducing mechanical pressure on surrounding tissues, thereby effectively avoiding various complications caused by material expansion and effectively avoiding the risk of traditional hemostatic materials swelling upon contact with water and compressing nerve tissue. Furthermore, the compounding of modified ergothioneine and modified chitosan in this application not only provides non-swelling and absorbable properties upon contact with water but also exhibits high adhesion and high antioxidant properties.

The invention discloses a system for predicting the risk of nerve injury caused by radiotherapy based on deep learning, and belongs to the technical field of medical artificial intelligence and radiotherapy, and the system comprises a neural structure automatic segmentation module, a dose-neural response modeling module, an individualized risk assessment module, a radiotherapy plan optimization module and a closed-loop feedback regulation unit. The system adopts an encoder-decoder deep network to perform high-precision segmentation on nervous tissues, establishes a dose-nerve response quantitative model by fusing dosiomics and radiomics characteristics, and realizes individualized risk assessment based on a multi-factor risk quantitative network. An optimization scheme for balancing tumor control and neuroprotection is generated through Pareto optimal search, collaborative optimization of all the modules is achieved through closed-loop feedback, and decision support is provided for precise radiotherapy.

The application provides a self-coiled flexible peripheral nerve electrode and a preparation method and application thereof, and the preparation method comprises the following steps: preparing a double-layer flexible liquid metal electrode with an exposed site; stretching the double-layer flexible liquid metal electrode, and then fixing two ends of the double-layer flexible liquid metal electrode to obtain a stretched electrode; coating a polymer prepolymer reaction solution on a surface of the stretched electrode which is opposite to the exposed site, and curing the polymer prepolymer reaction solution to form a fixing layer, so as to obtain a three-layer composite electrode; under the condition that the two ends are fixed, the fixing layer in the three-layer composite electrode faces downward, the fixing of one end of the three-layer composite electrode is released, and the three-layer composite electrode is self-coiled. The self-coiled flexible peripheral nerve electrode prepared by the preparation method of the self-coiled flexible peripheral nerve electrode has high conductivity, can realize self-coiling of the electrode, improves the detection quality and long-term stability of nerve signals, and avoids mechanical damage of nerve tissue caused by electrode implantation.

The invention discloses a mechanically controllable composite membrane material, which comprises a three-dimensional porous scaffold composed of bacterial cellulose, and bioactive ceramic nanoparticles are uniformly dispersed in and on the surface of the three-dimensional porous scaffold; the bioactive ceramic nanoparticles are one or more of tricalcium phosphate, bioactive glass, calcium silicate and hydroxyapatite. According to the invention, the bioactive ceramic nanoparticles are uniformly loaded inside and on the surface of the three-dimensional porous scaffold formed by bacterial cellulose, and the composite membrane material can be endowed with a unique biological function by adjusting the types of the bioactive ceramic nanoparticles. The composite membrane material prepared by an in-situ, ectopic or chemical deposition method and the like can realize synergy and balance of mechanical properties and biological functions, and the structural design of the composite membrane material provides necessary mechanical support and also gives consideration to flexible fit with fragile nervous tissues, so that the composite membrane material has a wide application prospect in the field of neurosurgery.

The invention relates to a spine intervertebral dilator which comprises a main support, a fixed supporting arm, a sliding supporting arm, a distraction blade and a control module, a biological impedance sensor array is integrated on the working surface of the distraction blade, and the biological impedance sensor array conducts real-time induction at the moment of touching nerve roots by detecting the electrophysiological characteristic difference of contact tissue; the control module receives impedance data of the biological impedance sensor array in real time, and when the biological impedance sensor array detects an impedance threshold value, the self-locking alarm module is triggered immediately and is self-locked; according to the spine intervertebral dilator, tissue electrophysiological characteristic differences are detected in real time through the integrated biological impedance sensor array, accurate recognition of nervous tissues is achieved in combination with multi-sensor fusion and a deep learning algorithm, a self-locking mechanism is triggered immediately when nerve roots are touched, and the spine intervertebral dilator is used for distraction of the nerve roots. The device has the advantages that nervous tissue is accurately recognized, real-time self-locking protection is achieved, and the risk of nerve injury in the operation is reduced.

The invention discloses an image display method, system and device and a storage medium, and the method comprises the steps: correcting a second medical image obtained in an operation preparation stage through a first medical image collected in a preoperative stage, obtaining a third medical image of a specified focus part in the operation preparation stage, and displaying the third medical image. And in response to a selection operation performed on the third medical image by the user, determining an initial operation image region for the to-be-processed bone tissue in the third medical image, further adjusting the initial operation image region according to an image region where a nervous tissue in the soft tissue in the third medical image is located, and determining and displaying an actual operative image region. The second medical image is corrected through the first medical image, and then the initial operation image area is adjusted through the image area where the nervous tissue in the soft tissue in the obtained third medical image is located, so that the actual operation image area which is used for the bone grinding operation process and can avoid damage to the nervous tissue is obtained.

The application discloses a handle type intelligent puncture instrument for intravertebral anesthesia, which comprises a shell, an anesthesia needle, a guide needle and a data processor, a fixing block for fixing the insertion end of the anesthesia needle is arranged at the front end of the shell, a base is fixed in the shell, a reverse L-shaped support is fixed at the front end of the base, a lead screw is arranged at the side of the reverse L-shaped support, a servo motor is arranged on the lead screw, a long slot is arranged on the reverse L-shaped support, the top of the servo motor passes through the slot and is sequentially connected with a first U-shaped clamping groove and a second U-shaped clamping groove which are respectively used for fixing the tail end of the anesthesia needle and the tail end of the guide needle, a ring-shaped pressure sensor is arranged in each of the first U-shaped clamping groove and the second U-shaped clamping groove, and the ring-shaped pressure sensor is connected with the data processor through a wire. The application has the advantages of reasonable design, convenient use, effective reduction of puncture difficulty, improvement of puncture success rate, real-time reflection of the needle insertion depth in the puncture process, avoidance of the risk of damaging nerve tissues, stable adsorption and improvement of work efficiency.

The utility model relates to the technical field of medical instruments, in particular to a nerve detacher which comprises a handle and a detacher body. The two ends of the stripper body are a fixed end and a stripping end respectively, the fixed end is fixedly installed on the handle, a negative pressure channel is arranged in the stripper body and provided with two inlets, the two inlets of the negative pressure channel are a first adsorption port and a second adsorption port respectively, the first adsorption port is located on one side of the stripping end, and the second adsorption port is located on the other side of the stripping end. The second adsorption port is located on the other side of the stripping end. According to the nerve detacher, the negative pressure channel is formed in the detacher body, so that the detacher body integrates the functions of detaching the nervous tissue and adsorbing the to-be-cleaned object, a doctor does not need to alternately use various tools, the to-be-cleaned object can be directly adsorbed after related operations are completed, tool replacement is reduced, and the operation is smoother and more efficient. In a complex operation, frequent tool replacement can be avoided, and pause and preparation time is shortened.

Methods and pharmaceutical compositions are provided, which make use of compounds disclosed herein, including (I). The methods and compositions are useful for producing local or regional anesthesia or analgesia in nerve tissue of a subject.

A phototherapy device (100) and a phototherapy instrument (500), comprising a near infrared irradiation module (110) used for emitting near infrared light to the head, and a control component (120) used for controlling the operation of the near infrared irradiation module (110) and coupled to the near infrared irradiation module (110). A method for using near infrared light for therapy, which comprises applying a first, optional second, optional third or more near infrared lights to the head of a patient. The device and method are used for treating Alzheimer's disease, improving brain mitochondrial function and ATP levels, promoting amyloid beta protein (Aβ) decomposition, reducing Aβ deposition, reducing damage to nerve cells, improving nerve tissue repair and regeneration capabilities, improving cognitive ability etc. A therapy method using the phototherapy device (100) or the phototherapy instrument (500), and a computer readable recording medium controlling required near infrared light.

The application relates to the technical field of image processing, in particular to an ultrasound-guided nerve blockage image processing method based on artificial intelligence, which comprises the following steps: obtaining the weight of other pixel points in the neighborhood of each pixel point according to the gradient amplitude of each pixel point, the distance between other pixel points in the neighborhood and the center point of the neighborhood, and the neighborhood radius; obtaining the weighted weight of each pixel point according to the weight of other pixel points in the neighborhood of each pixel point; obtaining the search window size according to the weighted weight of each pixel point and a window adjustment parameter, and obtaining a search window with each pixel point as the center according to the search window size; obtaining the iterative convergence condition according to the pixel point density difference in the search window and the distance of the clustering center; performing mean shift clustering according to the convergence condition and an initial clustering center to obtain a plurality of clustering clusters; and performing segmentation and visualization of nerve tissue regions according to the obtained clustering clusters.

The present application relates to a nerve conduit with a composite conductive ink modified coating, the nerve conduit comprising a nerve conduit body, and a dopamine coating and a conductive coating provided on the nerve conduit body, the conductive coating being a conductive coating prepared by coating and drying of a PEDOT:PSS solution with carbon nanotubes added.The present application also provides a preparation method and application of the nerve conduit.The nerve conduit of the present application is modified by CNT / PEDOT composite conductive ink, which not only improves the conductivity of the conduit material and accelerates the conduction of nerve electrical signals, but also promotes the adhesion, orientation and growth of nerve cells on the surface of the conduit, is conducive to promoting the alignment healing of the damaged nerve stumps, and has a hardness matching the interface of the nerve tissue; at the same time, the preparation method of the present application is simple and easy to operate, low in cost, and convenient for industrialized production and clinical application.

The invention discloses a fecal incontinence animal model making system. A gradient damping type electrical stimulation parameter regulation and control unit comprises a variable slope driving cam and a sliding block, and the peripheral surface of the variable slope driving cam is divided into an activation section, a maintenance section, an attenuation section and a reset section according to a stimulation period; one end of the sliding block abuts against the variable-slope driving cam, the other end of the sliding block is connected with the electrical stimulation parameter adjusting element, and the variable-slope driving cam rotates to drive the sliding block to move linearly to achieve gradient changes of electrical stimulation frequency and intensity. The three-stage locking type modeling unit realizes closed-loop operation and stable control of a modeling process; the bidirectional buffer type flexible stimulation unit is electrically connected with the gradient damping type electrical stimulation parameter regulation and control unit and is in direct contact with biological tissue, and mechanical damage of a probe to nervous tissue is avoided through a multi-layer buffer structure. Gradient dynamic adjustment of electrical stimulation parameters is achieved, accuracy and stability are achieved, electromagnetic interference is avoided, the dynamic activation process of a biological pathway is simulated, and a standardized experiment platform is provided for preclinical treatment scheme research.

The invention relates to the technical field of brain-computer interfaces, and discloses an implantable flexible microwire electrode assembly, which comprises an implantation part, an auxiliary needle, a transmission part and a fixing part, the implantation part comprises a plurality of flexible probes, the first flexible probe and the second flexible probe are respectively arranged at different positions of the first area, and the flexible probes are used for acquiring neuroelectric signals of biological nervous tissues; the auxiliary needle is used for driving the plurality of flexible probes to move, so that the plurality of flexible probes move at the same time; the transmission part is connected with the implantation part and is used for transmitting the electroneurographic signals to external equipment; and the fixing part is used for fixing the plurality of flexible probes and the transmission part. That is to say, the auxiliary needle drives the flexible probes to move at the same time, so that the flexible probes are implanted into the target position in the nervous tissue, and the situation that the biological nervous tissue is damaged by multiple times due to the fact that the flexible probes are implanted for multiple times is avoided.

The present invention discloses a posterior lumbar zero-profile fusion system and a method for using the same. The fusion system includes a fusion device and an impactor; the impactor includes a connecting seat, which is detachably connected to the fusion device; at least two inclined locking holes are provided on the front side of the fusion device; the axial height of the connecting seat is more than 1.5 cm; the connecting seat is provided with at least two inclined through-channels, and the outlet end of each channel corresponds to a locking hole; the angle between the channel axis and the connecting seat axis is 30 to 35 degrees. According to the present invention, it is only necessary to retract nerve tissues such as nerve roots and dura mater sacs once, and after the fusion device is placed between vertebrae by the impactor, the connecting seat is not directly removed. In the process of screwing in the locking screw, the locking screw and the screwdriver are completely in the connecting seat and the fusion device, and do not contact the surrounding nerve tissue to avoid damaging the surrounding nerve tissue of the vertebrae. Only one posterior spinal canal incision is required, which can greatly reduce surgical costs, surgical risks, surgical trauma and surgical time.

This invention discloses an electrode implantation tool. The distal end of the electrode is provided with a fixing component. The implantation tool includes an outer sheath and an inner sheath. The inner sheath includes an inner sheath tube and a first handle. The outer sheath includes an outer sheath tube and a second handle. The inner sheath tube can be inserted into the outer sheath tube. The first handle can be locked within the second handle. The second handle has at least a first locking position and a second locking position in the axial direction, allowing the first handle to move from the first locking position to the second locking position. The inner diameter of the inner sheath tube is smaller than the outer diameter of the fixing component, and the inner diameter of the outer sheath tube is larger than the outer diameter of the fixing component. Other parts of the electrode, excluding the fixing component, can be inserted into the inner sheath tube. This invention allows for a single puncture of the electrode and implantation tool near the target nerve tissue. After successful testing, the electrode is directly released and fixed, ensuring consistency between the test point and the implantation point.

The utility model relates to the technical field of medical instruments, and discloses an expandable UBE working channel. Comprising a first dilation piece, a second dilation piece and an opening mechanism, the opening mechanism can drive the first dilation piece and the second dilation piece to be attached to form a first surgical operation space, and the opening mechanism can drive the first dilation piece and the second dilation piece to be separated to form a second surgical operation space; one end of the second dilation piece is provided with an overhanging part, and the overhanging part is connected with a traction part which extends towards one side of the second dilation piece and in the direction away from the first dilation piece. The UBE working channel can flexibly adjust the operation space in the operation process, the situation that paravertebral muscular tissue hinders operation tool entering and exiting and fusion cage implanting is effectively avoided, meanwhile, the water outlet smoothness is improved, and therefore it is ensured that the visual field under the endoscope is clear, and hydrops in muscle gaps are prevented. And the traction part on the second expansion piece can assist an operator in flexibly pulling nerves without assistance of an assistant, so that the safety and accuracy of an operation are improved, and the nervous tissues of a patient are protected.

Tissue-processing containers are disclosed for facilitating multistep processing of tissue. Also disclosed are systems incorporating the tissue-processing containers that include shakers, incubators, controllers, and pumps. Multistep methods are disclosed for processing tissues using the tissue-processing containers. The tissue-processing containers are specially designed to achieve efficiencies in automated tissue processing, exposure of tissues to processing media, and multistep tissue processing protocols. The described tissue-processing containers comprise a cup-like cavity comprising a middle hole covered by a mesh screen, troughs for separate processing steps, and are stackable in a substantially airtight and substantially watertight manner. Tissues for processing using the described tissue-processing containers include nerve tissue. Also described herein is a transport housing for the transport of stacks of tissue-processing containers, and which may directly incubate those containers, or which may be placed inside a separate incubator for incubating the containers.

The application provides a biological nerve regulation electrode and a preparation and application method. A lead end of the electrode is fixedly connected with a lead resistance. The electrode comprises a metal wire and a biological compatible layer. The metal wire is arranged in an inner cavity of the electrode, and an outer surface of the metal wire is wrapped with the biological compatible layer. Ultrafine metal platinum and its alloy and the like are combined with a PI material to form a semi-flexible biological electrode, and multi-electrode contact stimulation can be realized. The electrode conductivity can be adjusted according to practical purposes, and the generation of local scars of nerve tissues is reduced. The PI has good insulation and solves biological rejection, and forms an electrode with good toughness together with the metal wire and the like. The preparation process technology is simple and easy to realize.

Provided are a contrast agent composition capable of specifically staining a nerve tissue, and the like. The composition has the affinity for myelin to specifically stain a nerve tissue compared to other tissues, has a wavelength in a near-infrared (NIR) region of 700 nm, and may stably emit fluorescence in vivo, and thus may be usefully used for real-time fluorescence imaging compared to other tissues.

The present invention relates to the technical field of peripheral nerve injury suturing, and specifically discloses a radio-stimulated surgical suture for promoting peripheral nerve healing, and its preparation method and application. The radio-stimulated surgical suture comprises a Mo core layer and a PLGA coating. The preparation method of the radio-stimulated surgical suture is as follows: using metallic Mo to form the core layer, ejecting a PLGA spinning solution through a spinneret, and curing it in a coagulation bath to form a film, and forming a uniformly coated PLGA coating on the Mo core layer by wet spinning technology to obtain a radio-stimulated surgical suture for promoting peripheral nerve healing. The radio-stimulated surgical suture prepared by the present invention obtains energy from an external electromagnetic field through electromagnetic induction and capacitive coupling, and forms a stable electric field locally between the suture and the wound, thereby acting on the damaged tissue. The suture can promote neuronal axon growth, Schwann cell migration, etc., and improve the efficiency of nerve tissue regeneration.