77 results about "Nerves tissue" patented technology

This invention discloses a charge regulation circuit and related products. The charge regulation circuit is used to regulate the neutralization current during the stimulation and neutralization cycle of nerve tissue. The charge regulation circuit includes an accumulation charge storage module that stores the charge accumulated on the nerve tissue due to stimulation and neutralization, and generates a first voltage based on the accumulated charge. A first voltage acquisition module acquires the first voltage in real time during the neutralization process on the nerve tissue. A first control module outputs a first control signal in response to the first voltage meeting a first preset condition, and outputs a second control signal when the first voltage meets a second preset condition. The charge regulation module adjusts the parameters of the neutralization current on the nerve tissue according to the first or second control signal to make the charge amounts of the two oppositely polarized charges accumulated on the nerve tissue equal. This solution can achieve long-term charge balance.

The embodiment of the invention discloses a testing device. The testing device comprises a cable, a connecting assembly and a stimulating assembly which are connected in sequence. Wherein the connecting assembly is provided with a limiting groove for limiting and fixing the implantable electrode, a plurality of conductive elastic sheets in conductive connection with the cable are arranged in the limiting groove, and the conductive elastic sheets are used for being detachably and electrically connected with a wire of the implantable electrode, so that the implanted implantable electrode is tested. The stimulation assembly is provided with a conductive probe electrically connected with the cable, and can apply a test electric signal to the nervous tissue to carry out a stimulation reaction test, thereby assisting in accurately confirming the position of the target spot. According to the testing device, the electrode testing function and the nerve stimulation testing function are integrated into a single device, the structure is compact, operation is visual, and the accuracy, smoothness and convenience of an operation are remarkably improved.

This application belongs to the field of medical dressing technology, specifically relating to dressing compositions, absorbable hemostatic dressings, and their preparation methods. This application provides a dressing composition that, by compounding modified chitosan with modified ergothioneine, forms a dressing composition with non-swelling properties upon contact with water. The chitosan in this application is esterified to introduce hydrophilic carboxyl groups, improving its solubility. Simultaneously, aspartic acid itself promotes cell proliferation and wound healing. Therefore, the dressing prepared from this composition can maintain a stable shape and volume in a body fluid environment, effectively reducing mechanical pressure on surrounding tissues, thereby effectively avoiding various complications caused by material expansion and effectively avoiding the risk of traditional hemostatic materials swelling upon contact with water and compressing nerve tissue. Furthermore, the compounding of modified ergothioneine and modified chitosan in this application not only provides non-swelling and absorbable properties upon contact with water but also exhibits high adhesion and high antioxidant properties.

The invention discloses a system for predicting the risk of nerve injury caused by radiotherapy based on deep learning, and belongs to the technical field of medical artificial intelligence and radiotherapy, and the system comprises a neural structure automatic segmentation module, a dose-neural response modeling module, an individualized risk assessment module, a radiotherapy plan optimization module and a closed-loop feedback regulation unit. The system adopts an encoder-decoder deep network to perform high-precision segmentation on nervous tissues, establishes a dose-nerve response quantitative model by fusing dosiomics and radiomics characteristics, and realizes individualized risk assessment based on a multi-factor risk quantitative network. An optimization scheme for balancing tumor control and neuroprotection is generated through Pareto optimal search, collaborative optimization of all the modules is achieved through closed-loop feedback, and decision support is provided for precise radiotherapy.

The application provides a self-coiled flexible peripheral nerve electrode and a preparation method and application thereof, and the preparation method comprises the following steps: preparing a double-layer flexible liquid metal electrode with an exposed site; stretching the double-layer flexible liquid metal electrode, and then fixing two ends of the double-layer flexible liquid metal electrode to obtain a stretched electrode; coating a polymer prepolymer reaction solution on a surface of the stretched electrode which is opposite to the exposed site, and curing the polymer prepolymer reaction solution to form a fixing layer, so as to obtain a three-layer composite electrode; under the condition that the two ends are fixed, the fixing layer in the three-layer composite electrode faces downward, the fixing of one end of the three-layer composite electrode is released, and the three-layer composite electrode is self-coiled. The self-coiled flexible peripheral nerve electrode prepared by the preparation method of the self-coiled flexible peripheral nerve electrode has high conductivity, can realize self-coiling of the electrode, improves the detection quality and long-term stability of nerve signals, and avoids mechanical damage of nerve tissue caused by electrode implantation.

The invention discloses a mechanically controllable composite membrane material, which comprises a three-dimensional porous scaffold composed of bacterial cellulose, and bioactive ceramic nanoparticles are uniformly dispersed in and on the surface of the three-dimensional porous scaffold; the bioactive ceramic nanoparticles are one or more of tricalcium phosphate, bioactive glass, calcium silicate and hydroxyapatite. According to the invention, the bioactive ceramic nanoparticles are uniformly loaded inside and on the surface of the three-dimensional porous scaffold formed by bacterial cellulose, and the composite membrane material can be endowed with a unique biological function by adjusting the types of the bioactive ceramic nanoparticles. The composite membrane material prepared by an in-situ, ectopic or chemical deposition method and the like can realize synergy and balance of mechanical properties and biological functions, and the structural design of the composite membrane material provides necessary mechanical support and also gives consideration to flexible fit with fragile nervous tissues, so that the composite membrane material has a wide application prospect in the field of neurosurgery.

The invention relates to a spine intervertebral dilator which comprises a main support, a fixed supporting arm, a sliding supporting arm, a distraction blade and a control module, a biological impedance sensor array is integrated on the working surface of the distraction blade, and the biological impedance sensor array conducts real-time induction at the moment of touching nerve roots by detecting the electrophysiological characteristic difference of contact tissue; the control module receives impedance data of the biological impedance sensor array in real time, and when the biological impedance sensor array detects an impedance threshold value, the self-locking alarm module is triggered immediately and is self-locked; according to the spine intervertebral dilator, tissue electrophysiological characteristic differences are detected in real time through the integrated biological impedance sensor array, accurate recognition of nervous tissues is achieved in combination with multi-sensor fusion and a deep learning algorithm, a self-locking mechanism is triggered immediately when nerve roots are touched, and the spine intervertebral dilator is used for distraction of the nerve roots. The device has the advantages that nervous tissue is accurately recognized, real-time self-locking protection is achieved, and the risk of nerve injury in the operation is reduced.

The application discloses a handle type intelligent puncture instrument for intravertebral anesthesia, which comprises a shell, an anesthesia needle, a guide needle and a data processor, a fixing block for fixing the insertion end of the anesthesia needle is arranged at the front end of the shell, a base is fixed in the shell, a reverse L-shaped support is fixed at the front end of the base, a lead screw is arranged at the side of the reverse L-shaped support, a servo motor is arranged on the lead screw, a long slot is arranged on the reverse L-shaped support, the top of the servo motor passes through the slot and is sequentially connected with a first U-shaped clamping groove and a second U-shaped clamping groove which are respectively used for fixing the tail end of the anesthesia needle and the tail end of the guide needle, a ring-shaped pressure sensor is arranged in each of the first U-shaped clamping groove and the second U-shaped clamping groove, and the ring-shaped pressure sensor is connected with the data processor through a wire. The application has the advantages of reasonable design, convenient use, effective reduction of puncture difficulty, improvement of puncture success rate, real-time reflection of the needle insertion depth in the puncture process, avoidance of the risk of damaging nerve tissues, stable adsorption and improvement of work efficiency.

The utility model relates to the technical field of medical instruments, in particular to a nerve detacher which comprises a handle and a detacher body. The two ends of the stripper body are a fixed end and a stripping end respectively, the fixed end is fixedly installed on the handle, a negative pressure channel is arranged in the stripper body and provided with two inlets, the two inlets of the negative pressure channel are a first adsorption port and a second adsorption port respectively, the first adsorption port is located on one side of the stripping end, and the second adsorption port is located on the other side of the stripping end. The second adsorption port is located on the other side of the stripping end. According to the nerve detacher, the negative pressure channel is formed in the detacher body, so that the detacher body integrates the functions of detaching the nervous tissue and adsorbing the to-be-cleaned object, a doctor does not need to alternately use various tools, the to-be-cleaned object can be directly adsorbed after related operations are completed, tool replacement is reduced, and the operation is smoother and more efficient. In a complex operation, frequent tool replacement can be avoided, and pause and preparation time is shortened.

The application relates to the technical field of image processing, in particular to an ultrasound-guided nerve blockage image processing method based on artificial intelligence, which comprises the following steps: obtaining the weight of other pixel points in the neighborhood of each pixel point according to the gradient amplitude of each pixel point, the distance between other pixel points in the neighborhood and the center point of the neighborhood, and the neighborhood radius; obtaining the weighted weight of each pixel point according to the weight of other pixel points in the neighborhood of each pixel point; obtaining the search window size according to the weighted weight of each pixel point and a window adjustment parameter, and obtaining a search window with each pixel point as the center according to the search window size; obtaining the iterative convergence condition according to the pixel point density difference in the search window and the distance of the clustering center; performing mean shift clustering according to the convergence condition and an initial clustering center to obtain a plurality of clustering clusters; and performing segmentation and visualization of nerve tissue regions according to the obtained clustering clusters.

The invention discloses a fecal incontinence animal model making system. A gradient damping type electrical stimulation parameter regulation and control unit comprises a variable slope driving cam and a sliding block, and the peripheral surface of the variable slope driving cam is divided into an activation section, a maintenance section, an attenuation section and a reset section according to a stimulation period; one end of the sliding block abuts against the variable-slope driving cam, the other end of the sliding block is connected with the electrical stimulation parameter adjusting element, and the variable-slope driving cam rotates to drive the sliding block to move linearly to achieve gradient changes of electrical stimulation frequency and intensity. The three-stage locking type modeling unit realizes closed-loop operation and stable control of a modeling process; the bidirectional buffer type flexible stimulation unit is electrically connected with the gradient damping type electrical stimulation parameter regulation and control unit and is in direct contact with biological tissue, and mechanical damage of a probe to nervous tissue is avoided through a multi-layer buffer structure. Gradient dynamic adjustment of electrical stimulation parameters is achieved, accuracy and stability are achieved, electromagnetic interference is avoided, the dynamic activation process of a biological pathway is simulated, and a standardized experiment platform is provided for preclinical treatment scheme research.

The invention relates to the technical field of brain-computer interfaces, and discloses an implantable flexible microwire electrode assembly, which comprises an implantation part, an auxiliary needle, a transmission part and a fixing part, the implantation part comprises a plurality of flexible probes, the first flexible probe and the second flexible probe are respectively arranged at different positions of the first area, and the flexible probes are used for acquiring neuroelectric signals of biological nervous tissues; the auxiliary needle is used for driving the plurality of flexible probes to move, so that the plurality of flexible probes move at the same time; the transmission part is connected with the implantation part and is used for transmitting the electroneurographic signals to external equipment; and the fixing part is used for fixing the plurality of flexible probes and the transmission part. That is to say, the auxiliary needle drives the flexible probes to move at the same time, so that the flexible probes are implanted into the target position in the nervous tissue, and the situation that the biological nervous tissue is damaged by multiple times due to the fact that the flexible probes are implanted for multiple times is avoided.

This invention discloses an electrode implantation tool. The distal end of the electrode is provided with a fixing component. The implantation tool includes an outer sheath and an inner sheath. The inner sheath includes an inner sheath tube and a first handle. The outer sheath includes an outer sheath tube and a second handle. The inner sheath tube can be inserted into the outer sheath tube. The first handle can be locked within the second handle. The second handle has at least a first locking position and a second locking position in the axial direction, allowing the first handle to move from the first locking position to the second locking position. The inner diameter of the inner sheath tube is smaller than the outer diameter of the fixing component, and the inner diameter of the outer sheath tube is larger than the outer diameter of the fixing component. Other parts of the electrode, excluding the fixing component, can be inserted into the inner sheath tube. This invention allows for a single puncture of the electrode and implantation tool near the target nerve tissue. After successful testing, the electrode is directly released and fixed, ensuring consistency between the test point and the implantation point.

The utility model relates to the technical field of medical instruments, and discloses an expandable UBE working channel. Comprising a first dilation piece, a second dilation piece and an opening mechanism, the opening mechanism can drive the first dilation piece and the second dilation piece to be attached to form a first surgical operation space, and the opening mechanism can drive the first dilation piece and the second dilation piece to be separated to form a second surgical operation space; one end of the second dilation piece is provided with an overhanging part, and the overhanging part is connected with a traction part which extends towards one side of the second dilation piece and in the direction away from the first dilation piece. The UBE working channel can flexibly adjust the operation space in the operation process, the situation that paravertebral muscular tissue hinders operation tool entering and exiting and fusion cage implanting is effectively avoided, meanwhile, the water outlet smoothness is improved, and therefore it is ensured that the visual field under the endoscope is clear, and hydrops in muscle gaps are prevented. And the traction part on the second expansion piece can assist an operator in flexibly pulling nerves without assistance of an assistant, so that the safety and accuracy of an operation are improved, and the nervous tissues of a patient are protected.

Provided are a contrast agent composition capable of specifically staining a nerve tissue, and the like. The composition has the affinity for myelin to specifically stain a nerve tissue compared to other tissues, has a wavelength in a near-infrared (NIR) region of 700 nm, and may stably emit fluorescence in vivo, and thus may be usefully used for real-time fluorescence imaging compared to other tissues.

The utility model belongs to the technical field of medical equipment, and particularly relates to an ablation needle with a nerve detection function. The utility model provides an ablation needle with a nerve detection function, which aims at solving the problem that the ablation needle in the prior art cannot immediately judge the damage condition of nerves around an operation site, and comprises an ablation needle rod main body and an ablation needle shell, the melting needle rod body is arranged in the melting needle shell in a sleeved mode, and one end of the melting needle rod body extends out of the melting needle shell. A working cavity is further formed between the ablation needle rod body and the ablation needle shell, a nerve detection assembly is arranged in the ablation needle shell in a sliding mode, and one end of the nerve detection assembly extends into the working cavity. And the end part of the nerve detection assembly can extend out of the ablation needle shell and surround the outer side of the end part of the ablation needle rod main body by sliding the nerve detection assembly. The nerve detection assembly can stretch out at any time to detect the activity condition of nerve tissue around the ablation needle rod body, and high efficiency and convenience are achieved.

The present invention provides improved methods for positioning of an implantable lead in a patient with an integrated EMG and stimulation clinician programmer. The integrated clinician programmer is coupled to the implantable lead, wherein the implantable lead comprises at least four electrodes, and to at least one EMG sensing electrode minimally invasively positioned on a skin surface or within the patient. The method comprises delivering a test stimulation at a stimulation amplitude level from the integrated clinician programmer to a nerve tissue of the patient with a principal electrode of the implantable lead. Test stimulations are delivered at a same stimulation amplitude level for a same period of time sequentially to each of the four electrodes of the implantable lead. A stimulation-induced EMG motor response is recorded with the integrated clinician programmer for each test stimulation on each electrode of the implantable lead via the at least one pair of EMG sensing electrodes so as to facilitate initial positioning of the implantable lead at a target stimulation region.

An example system includes processing circuitry; and an intravascular device comprising: an expandable substrate configured to be delivered within a blood vessel to a test therapy delivery site within a patient; one or more first electrodes positioned on the expandable substrate, where the one or more first electrodes are configured to deliver a nervous tissue stimulation test therapy to target nervous tissue of the patient; and one or more second electrodes positioned on the expandable substrate, where the one or more second electrodes are configured to sense one or more activation signals of the target nervous tissue, wherein the processing circuit is configured to determine whether activation of the target nervous tissue at the test therapy delivery location satisfies a target nervous tissue activation threshold based on the one or more sensed activation signals.

The invention provides naloxone-loaded adhesive hydrogel as well as a preparation method and application thereof, and relates to the technical field of adhesive hydrogel. The naloxone-carrying adhesive hydrogel is obtained by cross-linking boric acid oxidized chondroitin sulfate and methacrylated gelatin; and naloxone and hectorite nano particles are loaded in the naloxone carrying adhesive hydrogel. The naloxone-loaded hydrogel constructed by the invention is used for repairing damage of bone and nervous tissues, naloxone is used as a small molecule drug, has more stable physical and chemical properties, is easier to store, and also has the functions of promoting osteogenesis and neurogenesis, so that the combined use of various bioactive factors is reduced; and the naloxone-carrying adhesive hydrogel has adhesive performance, can effectively fill a bone defect area and form a stable repair microenvironment, and accelerates the bone and nervous tissue regeneration efficiency.

The present invention relates to a contrast agent composition capable of specifically staining nerve tissue, in which the composition has affinity for myelin and can specifically stain nerve tissue rather than other tissues, has a wavelength in the near-infrared (NIR) region of 700 nm, and can stably emit fluorescence in vivo, and thus can be effectively used for real-time fluorescence imaging to differentiate from other tissues.

The invention discloses a water-cooling radiofrequency ablation needle, which relates to the technical field of medical appliances, and comprises an ablation needle body, an electrode tube is arranged at the front end of the ablation needle body, a radiofrequency electrode is arranged in the electrode tube, the end part of the radiofrequency electrode extends out of the electrode tube, the end part of the radiofrequency electrode is fixedly connected with a temperature probe, and the temperature probe is of a conical structure. The lower bottom face of the temperature probe abuts against the end face of the electrode tube. Through the arrangement, the temperature probe can be closer to a nervous tissue ablation part, the influence of an intermediate medium on temperature conduction is reduced, accurate detection of the temperature of an ablation area is achieved, the temperature probe is of a conical structure, the tip design facilitates the temperature probe to penetrate through the tissue more smoothly and make direct contact with target nervous tissue, and compared with other shapes, the temperature probe is more convenient to use. The conical structure can reduce the tissue resistance, and the real tissue temperature can be obtained faster and more accurately.

The present invention provides a pharmaceutical composition capable of accelerating the regeneration rate of damaged areas in nerves. [Solution] A pharmaceutical composition for promoting nerve regeneration, comprising (A) a hyaluronic acid derivative into which a cholesteryl group has been introduced, (B) one or more factors selected from the group consisting of secretory sialic acid-binding immunoglobulin-like lectin-9 and monocyte chemotactic factor-1, and (C) a cell adhesion material derived from collagen; the average molecular weight of the hyaluronic acid derivative into which the cholesteryl group has been introduced is 5,000 or more and 50,000 or less; and a method for promoting nerve regeneration, comprising contacting any of the pharmaceutical compositions with a damaged site in nerve tissue.

An allergy testing system comprises a skin test device having a grip portion for holding the device. One or more legs extend from the grip, and each leg is oriented to interact with a well containing a potential allergen. Each leg has a test head, and each test head has a plurality of elongated spike members. The elongated spike members have a sharp end configured to receive the potential allergen from a well and to puncture a patient's skin. In addition, each test head has a touch activator. The touch activator is longer than the plurality of elongated spike members, such that during an allergy test, the touch activator comes into contact with the skin prior to the elongated spike members, causing the touch activator to activate nerve tissue that blocks transmission of pain, resulting in a reduction of pain and / or discomfort during testing.

The invention discloses an electric connector of a minimally invasive implantable electrode, which comprises a male head connecting module, a female head connecting module, a first wire and a second wire, and is characterized in that the male head connecting module is electrically connected with the first wire, and the female head connecting module is electrically connected with the second wire; the first wire comprises a first connecting section, and the first connecting section is a section where the first wire is connected to the male head connecting module; the second wire comprises a second connecting section, and the second connecting section is a section where the second wire is connected to the female head connecting module; the male head connecting module and the female head connecting module can be mutually jointed and electrically connected along a preset direction, and the preset direction is basically perpendicular to the extension direction of the first connecting section / the second connecting section; the male head connecting module and the female head connecting module are jointed to form an assembly body; according to the electric connector, the whole implant does not need to be taken out when the stimulator of the implant is replaced, only the module needs to be separated and taken out of the stimulator, and nervous tissue damage caused by secondary implantation is avoided.

The application provides a nerve mapping assembly, a nerve mapping catheter and a nerve mapping system, the nerve mapping assembly comprising an elastic structure, an ultrasonic transducer array and a first support tube, the elastic structure and the first support tube are both adapted to be arranged in an arc shape, the elastic structure is arranged in the first support tube; the ultrasonic transducer array comprises a plurality of ultrasonic transducer elements; the elastic structure has a first guide wire cavity penetrating through a proximal end and a distal end thereof, when a guide wire is inserted into the first guide wire cavity, the elastic structure, the first support tube and the ultrasonic transducer array can tend to be in a linear state; the ultrasonic transducer array is used for emitting ultrasonic waves to a target region, also receives echoes and converts them into corresponding electrical signals, so as to generate a corresponding target region ultrasonic image. The application can determine the position of nerve tissue according to the target region ultrasonic image, and can completely avoid uncontrollable factors caused by disordered and targetless electric stimulation.

The invention discloses a method for selecting design parameters of a pulse ablation catheter based on finite element analysis, which relates to the technical field of medical instruments and comprises the following steps of: obtaining a registered and aligned DICOM (Digital Imaging and Communications in Medicine) format image data set through high-resolution CT (Computed Tomography) and DTI (Differential Train Imaging) multi-modal image scanning of the skull base of a patient; based on a high-fidelity simulation model, an optimal pulse voltage parameter combination is obtained through gradient optimization solution under geometric constraints, and a catheter manufacturing treatment scheme is generated through catheter 3D printing manufacturing and an intraoperative treatment scheme; according to a catheter manufacturing treatment scheme, a catheter head end containing an electrode slot position and an optimized 3D printing file are constructed, and design parameters of the pulse ablation catheter are obtained. According to the method, the composite nervous tissue model fused with the nerve fiber trend is constructed, and the anisotropic conductivity is defined, so that real conduction simulation of an electric field in the axon direction in finite element simulation is realized, and precise catheter design parameters with anatomy suitability and electrophysiology targeting are obtained.

The present invention belongs to the technical field of biochemistry; and specifically relates to an anti-tumor prodrug, and a preparation method therefor and the use thereof. The anti-tumor prodrug is composed of the tail of nervonic acid and the head of a hydrophilic chemotherapeutic drug. The hydrophilic chemotherapeutic drug is gemcitabine, and the tumor is glioma. An acid-sensitive amphiphilic prodrug compound is synthesized on the basis of using a nutrient nervonic acid capable of penetrating the blood-brain barrier and a chemotherapeutic drug as raw materials. Once the prodrug compound reaches a tumor site, an acid-sensitive bond is automatically cleaved due to the low pH in the tumor microenvironment, causing the prodrug compound to separate into the nervonic acid and the chemotherapeutic drug to perform respective functions thereof, wherein the chemotherapeutic drug kills glioma cells, and the nervonic acid repairs nerve tissues, thereby fundamentally solving the toxic side effects of the chemotherapeutic drug, and integrating therapeutic and rehabilitative effects.

Retractor (1) for surgical applications in spinal fusion, comprising a handle section (2) for actuation with a central section (3) arranged thereon having a longitudinal axis and a tool section (4) arranged directly on the central section (3) for supporting tissue of a spine, wherein the tool section (4) comprises a first leg section (41) that can be brought into contact with nerve tissue of the spine and which extends at a first angle (α1) in a first direction to the longitudinal axis of the central section (3) and a second leg section (42) that can be brought into contact with dural tissue of the spine and which extends at a second angle (α2) in a second direction opposite to the longitudinal axis of the central section (3), such that an operating area on the spine can be opened between the first and the second leg sections (41, 42).wherein the first leg section (41) has a first end section (411) angled at a third angle (Φ1) at the open end and the second leg section (42) has a second end section (421) angled at a fourth angle (Φ2) at the open end and a flat surface of the second leg section (42) is a surface that widens with respect to the longitudinal axis of the middle section (3).

1. The name of the design product: handle of radio frequency temperature control coagulator. 2. The use of the design product: pulse regulation and thermal coagulation operation for treating pain of nerve, tissue, lumbar vertebra and cervical vertebra. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo best indicating the design points: perspective view.

The invention provides a construction method of a spinal cord injury animal model for maintaining the integrity of subarachnoid space, which comprises the following steps: adopting a mammal with spinal cord injury, clamping and closing the opening of the dura mater of the mammal, dripping biological glue in alignment with the clamped and closed position, and suturing after the biological glue becomes frost and the dura mater is adhered together. The invention also provides application of the spinal cord injury animal model for maintaining the integrity of the subarachnoid space in research on motor function, nervous tissue recovery or tissue morphology recovery of animals after spinal cord injury. The application shows that after experimental spinal cord injury is caused, the motion function and histomorphological recovery of a mouse can be improved by tightly suturing the dura mater.