25 results about "Bladder function" patented technology

The present invention relates to a composition for preventing or treating bladder diseases, a composition for preventing or treating neuropathic pain, neuroinflammation or inflammatory skin diseases, or the therapeutic use of a novel compound YJ102, the compound YJ102 of the present invention inhibits neuropathic pain due to various reasons, ameliorates urination disorders due to spinal cord injury, restores bladder hypertrophy and bladder function, inhibits erythema and keratinogenesis, which are main symptoms of psoriasis, in a psoriasis animal model, and has a superior effect than conventional drugs. The composition can inhibit increase of the thickness of the epidermal layer and spleen hypertrophy caused by psoriasis, and can be used for treating various difficult nervous system diseases or bladder diseases.

The application discloses a bladder function dynamic evaluation method based on multi-modal biological signal fusion, and steps include: synchronously collecting multi-modal signals of the bladder through a flexible ultrasonic array, a differential electromyography sensor and an impedance chromatography module; adopting a variational autoencoder combined with a time attention mechanism to perform spatio-temporal feature alignment and fusion on the multi-modal signals, and generating a feature representation of a unified time scale; constructing a graph convolutional neural network embedded with a bladder pressure-volume differential equation to perform deep analysis on the fused features, and outputting a detrusor contraction force grade and an abnormal detection probability; and based on a regional benchmark library and individual physiological parameters constructed based on a federal learning framework, dynamically calibrating the analysis result, and forming a personalized evaluation benchmark. The method breaks through the limitation of traditional single parameter evaluation through three-modal fusion of ultrasonic volume monitoring, electromyography contraction strength representation and impedance tissue characteristic analysis, and significantly improves the comprehensiveness of bladder function evaluation and the accuracy of clinical decision-making.

The invention discloses a bladder function improvement system and method for urethral dilation. The system identifies tissue viscoelasticity and calculates mechanical resonance frequency on the basis of a Kelvin-VoIP model, and a dynamic pulsating expansion pressure field fitting tissue characteristics is generated through a dynamic rheology driving unit. According to the method, a mechanical electrophysiology double-frequency phase locking technology is adopted, nerve electrical stimulation is accurately anchored to the wave crest phase of mechanical pressure waves, and the synergistic interaction of tissue physical remodeling and nerve reflex arc repairing is achieved. Meanwhile, a spasm-induced fluid impedance instantaneous damping feedback mechanism is introduced into the system, and when abnormal myoelectricity is monitored, the rigidity of the system is instantaneously reduced so as to actively defend damage caused by spasm. Closed-loop control is established through quantified rheological indexes, the problems that traditional rigid expansion is large in blindness and prone to tearing are solved, and precise, intelligent and safe rehabilitation treatment of urethrostenosis is achieved.

The utility model belongs to the field of ureter guiding sheaths, particularly relates to a ureter guiding sheath capable of reducing internal pressure of a renal pelvis and pressure of a bladder, and aims to solve the problems that when an existing guiding sheath injects water into a kidney during an operation, the pressure of the kidney is too large, water flows back into blood, infection risk is increased, and the operation time is prolonged. Liquid in the bladder is gradually increased, bladder pressure is increased, the bladder is overfilled, and the bladder function is damaged. According to the scheme, the catheter comprises a guide sheath tube, a bendable catheter is arranged at the front end of the guide sheath tube, a plurality of evenly-distributed second holes are formed in the outer portion, away from the bendable catheter, of the guide sheath tube, and a plurality of evenly-distributed first holes are formed in the outer portion of the front end of the bendable catheter and the outer portion of the front end of the guide sheath tube. Through the arrangement of the first hole and the second hole, liquid in the kidney and the bladder can be further drained out of the body through the liquid passing ability of the measuring holes, the pressure in the kidney and the pressure of the bladder are effectively relieved, and it is ensured that drainage is more sufficient and effective.

1. Name of the product in this design: Smart Diaper Pad (I). 2. Purpose of this design: This design is an electronic patch used to intelligently monitor a patient's bowel and bladder function and alert nursing staff via an alarm. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

A system for modulating bladder function is disclosed. A system for evaluating the electrophysiological function of a bladder is disclosed. Methods for performing a controlled surgical procedure on a bladder are disclosed. A system for performing controlled surgical procedures in a minimally invasive manner is disclosed. An implantable device for monitoring and / or performing a neuromodulation procedure on a bladder is disclosed.

The present invention relates to a novel compound YJ102 for the prevention or treatment of bladder diseases, a composition for the prevention or treatment of neuropathic pain, neuroinflammation, or inflammatory skin diseases, or for the treatment of intractable neurological diseases including neurogenic bladder. The compound YJ102 of the present invention suppresses neuropathic pain caused by various factors with superior efficacy compared to conventional drugs, improves urinary dysfunction caused by spinal cord injury, restores bladder enlargement and bladder function, suppresses the development of erythema and scaling, which are major symptoms of psoriasis in animal models of psoriasis, suppresses thickening of the epidermal layer, and suppresses splenomegaly caused by psoriasis. Therefore, it can be utilized for the treatment of various intractable neurological diseases or bladder diseases.

The application discloses a traditional Chinese medicine composition for treating overactive bladder (OAB) with kidney yang deficiency, a preparation method and application thereof. The composition is composed of three medicinal materials of fennel, cherokee rose and stir-baked dodder seed, and is formulated according to an optimal ratio. The composition improves the symptoms of frequent urination caused by OAB according to the TCM syndrome differentiation and treatment concept. The composition has the advantages of simple prescription, exact curative effect, no obvious toxic and side effects, simple medicine, easy quality control, low cost, reduced medical burden of patients, saved traditional Chinese medicine resources, and the like. The composition can obviously improve the urination indexes, OABSS scores and TCM syndrome scores of patients, improve the life quality of patients, has few adverse reactions, good tolerance and no drug dependence, and can significantly repair the bladder function of model rats and reduce the urination frequency. The product is prepared by adopting a volatile oil inclusion, alcohol extraction and water extraction combination and spray drying granulation process. The product contains 42 kinds of chemical components, mainly flavones and phenolic acids, has obvious comprehensive advantages, and has good industrialization and clinical application prospects.

The invention discloses a wearable bladder function evaluation system based on spinal segment electrophysiological signal monitoring, which comprises a physiological signal acquisition module and a data processing module, and is characterized in that the data processing module comprises an analog front-end circuit unit, an analog-to-digital conversion circuit unit and a control unit; the physiological signal acquisition module is used for acquiring peripheral nerve electrophysiological signals and central nerve electrophysiological signals of a human body; the analog front-end circuit unit is used for performing signal amplification and filtering processing on the peripheral nerve electrophysiological signal and the central nerve electrophysiological signal; the analog-to-digital conversion circuit unit performs analog-to-digital conversion on the amplified peripheral nerve electrophysiological signal and the amplified central nerve electrophysiological signal to obtain a peripheral nerve electrophysiological digital signal and a central nerve electrophysiological digital signal; the control unit is used for monitoring the bladder function according to the peripheral nerve electrophysiology digital signal and the central nerve electrophysiology digital signal.

The invention relates to a multi-target parameter self-adaptive noninvasive tibial nerve stimulation method and system, and aims to solve the problem that an existing nerve regulation device cannot perform on-demand treatment according to dynamic change of symptoms of a patient. The induced foot sole neural signals are collected, and the F wave peak value amplitude and the incubation period meeting the stability condition are extracted in a preset time window to serve as real-time feedback signals. And establishing an individualized target interval based on the F-wave characteristic, calculating a dynamic deviation of a current F-wave peak value amplitude relative to the interval, and iteratively adjusting parameters such as stimulation intensity, frequency, pulse width and a double-target stimulation intensity proportion by taking a mean square error of the dynamic deviation as a loss function and adopting a gradient descent method until the F-wave characteristic is converged into the target interval. The dynamic change of the bladder function is self-adapted, and multi-target closed-loop self-adaptive stimulation of the tibial nerve is realized.

The application discloses a bladder drainage device which comprises a catheter, a bare sensing electrode, a bare sensing electrode connector, an inner flower crown anti-stone ballon, a heating electrode, a heating electrode connector, a bladder function regulating electrode, a bladder function regulating electrode connector, a left side water injection hole, a water injection catheter interface, a right side drainage hole, a water outlet catheter interface, an outer fixed balloon, an outer fixed balloon water injection hole and an inner flower crown anti-stone balloon water injection hole. The application has the advantages that the drainage device is integrated with the bare sensing electrode, the bladder function regulating electrode contact, the heating electrode and the anti-stone balloon, the diagnosis and treatment function modules are integrated, and the difficult problems that part of neurogenic bladder needs to frequently replace catheters, urine drainage is released and bladder function recovery is promoted can be solved.

The invention relates to the technical field of data processing, and discloses a hydrocephalus assessment method and system based on a bladder pressure dynamic monitoring device. The hydrocephalus assessment method based on the bladder pressure dynamic monitoring device comprises the steps that wrist sympathetic nerve and lumbosacral electromyographic signals are collected and filtered; extracting a specific frequency band power spectrum integral value and a root-mean-square value to fuse and calculate an equivalent bladder pressure value; calculating a detrusor muscle activity index, a compliance index and a night fluctuation coefficient to form a pressure mode; obtaining pressure mode calculation improvement rate judgment reactivity before and after liquid discharge; and calculating a comprehensive improvement index through a weighting algorithm to determine a surgical indication level. The problem that in the prior art, continuous non-invasive monitoring and objective quantitative evaluation cannot be conducted on the bladder function of an iNPH patient is solved, and the accuracy of cerebrospinal fluid drainage test effect evaluation is improved.

To provide a medicinal use of a cell preparation for treating underactive bladder, and a method for producing the same.SOLUTION: Provided is a use of a cell preparation in the manufacture of a pharmaceutical product for a medical use related to underactive bladder, wherein the cell preparation comprises a cell cluster, and the cell cluster is formed by seeding a plurality of mesenchymal stem cells in a culture device having a plurality of culture wells and culturing the mesenchymal stem cells under a condition that a surface of the culture well has a low protein adhesion coating. Also provided is a method of producing a cell preparation for medical use on an underactive bladder, comprising: seeding a plurality of mesenchymal stem cells into a culture device having a plurality of culture wells, wherein a surface of the plurality of culture wells comprises a low protein adhesion coating; and culturing the mesenchymal stem cells to form a cell cluster.SELECTED DRAWING: Figure 1

The application provides a kind of spatiotemporal dynamic big data analysis system and method based on wearable ultrasonic equipment, belongs to the cross technical field of medical equipment and big data analysis, including: wearable ultrasonic equipment, adhere to the lower abdomen of subject, for transmitting ultrasonic wave and receiving echo signal;Spatiotemporal dynamic big data analysis module is used to form spatiotemporal dynamic dataset according to echo signal and time stamp, is handled and analyzed based on bladder analysis model, automatically identifies bladder boundary, calculates bladder volume and bladder wall thickness and generates clinical impression;Display module and data transmission module.The beneficial effect is: realize the home monitoring of bladder function, reduce the number of patient hospitalization and outpatient follow-up frequency, reduce medical expenditure, simultaneously provide data support for telemedicine, optimize medical resource allocation.

The invention provides a closed-loop diagnosis and treatment method for bladder dysfunction, and relates to the technical field of biomedical monitoring and treatment. Comprising the following steps: acquiring a signal related to bladder filling through a non-invasive bladder volume measuring device, and analyzing the signal in real time to estimate the bladder volume; subsequently, the measuring device compares the estimated volume with a preset capacity threshold value and generates a trigger signal for activating an external excitation source when the volume reaches or exceeds the threshold value. The external excitation source outputs mechanical energy after receiving the trigger signal, and the mechanical energy is transmitted to the wireless nerve stimulator in the body in a wireless mode; and the stimulator converts the received mechanical energy into electric energy, and the electric energy is processed by the energy management circuit to generate an electric stimulation signal for regulating and controlling neural activity, so that the adjustment of the bladder function is realized. The defects that in a traditional diagnosis and treatment scheme, monitoring continuity is poor, intervention depends on professionals, individualized regulation and control cannot be achieved, and a closed-loop control mechanism is lacked are effectively overcome.

1. Name of the product in this design: Smart Diaper Pad (II). 2. Purpose of this design: This design is an electronic patch used to intelligently monitor a patient's bowel and bladder function and alert nursing staff via an alarm. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

The invention belongs to the technical field of traditional Chinese medicine preparation, and discloses a traditional Chinese medicine composition for cesarean section postoperative urinary retention, the traditional Chinese medicine composition comprises an oral medicine and an external application medicine, the oral medicine comprises cinnamon, rhizoma anemarrhenae, cortex phellodendri, schizonepeta, rheum officinale, immature bitter orange, rhizoma cyperi, talc, polyporus umbellatus, rhizoma alismatis, roasted rhizoma atractylodis macrocephalae, platycodon grandiflorum, poria cocos, red ginseng and mangnolia officinalis; the medicine for external application comprises cortex cinnamomi, rhizoma anemarrhenae, cortex phellodendri, herba schizonepetae, radix et rhizoma rhei, fructus aurantii immaturus, rhizoma cyperi, talc, polyporus umbellatus, rhizoma alismatis, roasted rhizoma atractylodis macrocephalae, radix platycodonis, poria cocos, radix ginseng rubra, cortex magnoliae officinalis The invention aims to achieve the effects of relaxing muscles and tendons, dredging collaterals and relieving postoperative pain, and by virtue of the stimulation of the externally applied medicine, the medicine and heat flow directly reach the bladder, the bladder gasification function is recovered, the bladder function recovery is effectively promoted, the postoperative urination time is obviously shortened, the residual urine volume of urination is reduced, and the urinary retention symptom of a puerpera is relieved; the risk of complications such as postoperative infection and postpartum hemorrhage is reduced.

The invention provides a noninvasive bladder function monitoring method and system based on time sequence prediction, and the method comprises the steps: training a bladder pressure prediction model based on the clinical data of a patient and the UDS examination data of the patient; obtaining water drinking urethral catheterization data, heart rate and environment temperature and humidity of a patient to be monitored, and inputting the data into the trained urine generation rate prediction model to obtain real-time bladder volume data; and inputting the clinical data of the to-be-monitored patient and the predicted bladder volume data into the bladder pressure prediction model to obtain a bladder pressure prediction value of the to-be-monitored patient. By collecting UDS images and diagnoses of a large number of patients and combining clinical data of the patients, drinking urine catheterization data, heart rate and environment temperature and humidity, the prediction model is trained, the bladder pressure of the patients at different disease stages and under different bladder filling degrees is predicted, a non-invasive AI UDS monitoring means is provided for the patients, and the accuracy of bladder pressure monitoring is improved. And a patient is helped to better manage the bladder in a home state.

The invention belongs to the technical field of biological medicines, and particularly relates to uFAP CAR mRNA, a lipid nanoparticle entrapped with the uFAP CAR mRNA, and a preparation method and application of the uFAP CAR mRNA and the lipid nanoparticle entrapped with the uFAP CAR mRNA. The invention provides a uFAP CAR (chimeric antigen receptor) mRNA (messenger ribonucleic acid). The nucleotide sequence of the uFAP CAR mRNA is as shown in SEQ ID No. 1; the uFAP CAR mRNA-entrapped lipid nanoparticles can specifically kill activated fibroblasts expressing FAP, inhibit collagen deposition, reverse the bladder fibrosis process and effectively improve the bladder function, and a brand-new and efficient treatment strategy is provided for treatment of bladder fibrosis related diseases.

The utility model belongs to the technical field of medical supplies, and provides a urinary catheter drainage bag which comprises a cover plate, a handle rotatably connected to the top of the cover plate, a bag body fixedly connected to the bottom of the cover plate, a double-layer structure, a spring arranged inside the bag body, a bottom ring fixedly connected to the bottom of the bag body, and a drainage tube fixedly connected to the top of the cover plate. The end part of the drainage tube is fixedly connected with a connector; the adjusting assembly comprises a shell arranged on the drainage tube; a liquid discharge assembly; by lengthening the drainage tube, the phenomenon that the drainage tube is prone to disengagement when a patient moves due to insufficient length of the drainage tube is prevented, by arranging the cover plate and the bottom ring, once urine flows into the bag body, the bag body can become a fixed cylinder, the urine volume can be measured more accurately, the bag body can be folded by being clamped into the clamping groove through the buckle before being used, and therefore the urine volume can be measured more accurately. By adjusting the assembly, multiple functions, such as convenient examination, bladder perfusion, auxiliary bladder function exercise, urination flow velocity control and regurgitation resistance, are realized.

The invention relates to the technical field of artificial intelligence, in particular to a urinary incontinence self-management strategy optimization method based on reinforcement learning, and aims to solve the problem that an existing intervention strategy lacks individuation, dynamic adaptability and long-term optimization ability. According to the method, a closed-loop intelligent decision-making system is constructed, and a personalized strategy is optimized online through multi-dimensional user state representation, continuous action space intervention (including pelvic floor muscle prompt, drinking water adjustment and urination delay excitation), a composite reward function and a DDPG reinforcement learning algorithm. According to the system, a flexible sensor, sEMG and user feedback data are fused, and dynamic balance of comfort, bladder function recovery and intervention invasiveness is realized in combination with security constraints, an interpretability module and an edge-cloud collaborative architecture.

The disclosure relates generally to an extended use systems and devices for management of bladder function for people with urinary dysfunction. The system includes a catheter and a valve that can control fluid flow. The catheter can be placed inside the bladder using devices that facilitate insertion and extraction. The placement of the catheter can be done by a trained individual such as a patient, as well as a clinician, a nurse, or a caretaker. Once placed inside the bladder, the catheter can be fully-internal, meaning no portion of the catheter is visible from outside of the patient's body.

The invention discloses an application of dimethyl sulfoxide in preparation of a medicament for treating urinary tract infection. The dimethyl sulfoxide disclosed by the invention can inhibit the growth of drug-resistant and non-drug-resistant uropathogenic escherichia coli in vitro or in vivo, and has a bactericidal effect. Dimethyl sulfoxide is used for perfusing the bladder with urinary tract infection, so that colonization of uropathogenic escherichia coli in the bladder can be remarkably reduced, bladder edema and inflammation are relieved, and the bladder function is improved. Particularly, the dimethyl sulfoxide can promote the shedding of infected bladder epithelial cells and relieve inflammatory response. Therefore, the dimethyl sulfoxide disclosed by the invention can be used for preparing the medicine for treating urinary tract infection, has a remarkable curative effect on urinary tract infection caused by multiple drug-resistant pathogens, provides a solution for treating UTI clinical management with increasingly severe antibiotic resistance, and has a wide application prospect.

The invention discloses a bladder pressure and abdominal pressure measurer which is characterized in that a catheter which can be led to or connected with a drainage tube or a catheter is upward to form a bladder pressure display tube, and the top of the pressure display tube is downward to form an automatic urine discharge pipeline; a vent hole or a connecting piece with the vent hole is arranged on a liquid guide pipeline joint or a liquid guide pipeline connected with the front part of the pressure display pipe; and the automatic urine discharge pipeline is connected with a waste liquid collection bag. The invention aims to overcome the defects in the prior art, and provides a disposable product capable of measuring the pressure of the bladder and measuring urine to judge the function of the bladder at the same time.

The utility model relates to an intelligent training device for bladder function recovery after bladder cancer operation, which belongs to the technical field of medical instruments and comprises a bladder simulating component, the top of the bladder simulating component is connected with an electronic inflator pump and an electronic infusion pump in a training control system component, and the bottom of the bladder simulating component is connected with the urethra of a patient through a catheter. A protective shell is arranged outside the training control system assembly, a microprocessor is arranged in the training control system assembly, and the training control system assembly is connected with the biofeedback sensor assembly. The biofeedback sensor assembly is composed of a sensor body and a signal transmission line and used for collecting pelvic floor muscle electrical activity signals. The microprocessor of the training control system assembly controls the inflation and liquid filling of the bladder simulation assembly and simulates the bladder filling and emptying process according to the received signal in combination with a preset algorithm. According to the device, the bladder function can be accurately simulated, personalized training is achieved, a rehabilitation scheme is optimized through multi-dimensional data collection and analysis, the bladder function recovery effect of a bladder cancer postoperative patient is effectively improved, and the life quality of the patient is improved.