16 results about "Detrusor muscle" patented technology

The invention relates to the field of antibodies, in particular to a monoclonal antibody for treating overactive bladder and application of the monoclonal antibody. The monoclonal antibody specifically recognizes and is combined with an adrenergic receptor beta3 (ADR beta3), the monoclonal antibody is obtained through a hybridoma technology, and the M13 monoclonal antibody with high affinity is successfully screened out. The M13 antibody promotes the increase of cAMP concentration in smooth muscle cells and activates a PKA pathway by activating an ADR beta3 receptor, thereby promoting the relaxation of bladder smooth muscles, increasing the bladder capacity and reducing the non-autonomous contraction of detrusor muscles. Animal experiments prove that the M13 monoclonal antibody can effectively improve the urination frequency and urine volume of a mouse OAB model, and has a good clinical application prospect. The monoclonal antibody and the preparation method thereof can be widely applied to the field of treatment of overactive bladder.

The present invention discloses an auxiliary pressure-applying device for stress urinary incontinence, and relates to the technical field of medical devices. The present invention provides an auxiliary pressure-applying device for stress urinary incontinence, comprising a receiving chamber, a mounting seat, a regulator, and a restraining tentacle. The receiving chamber is arranged on the mounting seat, and a regulator is arranged in the mounting seat. A plurality of restraining tentacles are evenly arranged around the receiving chamber. The regulator autonomously controls the operation of the first regulating valve and the second regulating valve. No active intervention is required in this process, which can not only restrain the urethral sphincter and prevent urine leakage, but also does not affect normal urination. The restraining tentacle is used to restrain the bladder detrusor muscle in the receiving chamber. The regulator and the restraining tentacle are designed in linkage, and the patient's abdominal pressure can be adjusted at any time. The autonomous control is more efficient and safe, and has excellent practicality. The present invention is installed outside the bladder detrusor muscle and urethral sphincter, and the device is limited by the external urethral sphincter to prevent the device from falling off.

The pet collar with potty-sensing capability is adapted for use by a companion animal. The pet collar with potty-sensing capability is worn by the companion animal. The pet collar with potty-sensing capability detects the heart rate of the companion animal. The pet collar with potty-sensing capability detects the electric activity of the nervous system associated with the detrusor muscle of the companion animal. The pet collar with potty-sensing capability identifies known correlations between: a) the heart rate of the companion animal; b) the electric activity associated with the detrusor muscle; and, c) the urgency of the need of the companion animal to urinate. The pet collar with potty-sensing capability generates an alarm condition to indicate that the companion animal needs to urinate.

The application provides a transcutaneous tibial nerve stimulation method and system based on an adaptive algorithm, an electronic device and a readable storage medium, and belongs to the technical field of nerve electrical stimulation. The method comprises the following steps: obtaining an individual physiological characteristic baseline of a subject, which represents the occurrence regularity of bladder activity instability events of the subject in a preset time period; acquiring current physical activity data of the subject in real time, and identifying characteristic pre-activities associated with instability events based on the individual physiological characteristic baseline to predict the occurrence time of instability events; triggering an electrical stimulation pulse for intervention before the occurrence time to inhibit abnormal activity of the bladder detrusor; acquiring feedback data after the intervention and dynamically adjusting the individual physiological characteristic baseline and / or the electrical stimulation pulse output parameter to perform individual closed-loop calibration regulation on the subject. The application realizes dynamic prediction and intervention of individual bladder activity through an adaptive closed-loop intelligent stimulation strategy.

The application relates to the technical field of image processing, in particular to a bladder cancer contour drawing method and system based on ultrasonic images. The method comprises the following steps: acquiring bladder ultrasonic images and contrast images under each view angle; obtaining a muscle layer infiltration depth factor according to the shape, length and surrounding pixel gray scale of blood vessels in each region in the ultrasonic images, and determining a deviation error factor of each region under each view angle; obtaining a pulling error sensitive factor according to the volume change of the bladder cavity, the distance between the tumor region and the texture region of the urinary muscle bundle, the overall tumor displacement direction and the local muscle bundle main direction in each frame of the bladder ultrasonic images under each view angle, and then obtaining the registration error cumulative value of each region under each view angle; and comprehensively obtaining a drawing error coefficient by combining the deviation error factor, the registration error cumulative value and the pulling error sensitive factor, adjusting an initial edge reservation parameter, and obtaining a bladder cancer contour drawing result. The application improves the accuracy of the bladder cancer contour drawing result.

The invention relates to the technical field related to medical treatment, and discloses a bladder nerve detrusor muscle disorder recovery condition data acquisition method and system, and the method comprises the following steps: an auxiliary urination stage: a drinking water monitoring step; a urination monitoring step: using the urination device to set urination reminding time, and sending out urination reminding when the urination time is up; the urination device records the urination amount and the urination time; in the autonomous urination stage, the urination device is taken down; the water drinking monitoring step is the same as the water drinking monitoring step in the auxiliary urination stage; urination monitoring: canceling urination reminding, and recording urination amount and urination time; the water drinking and urination related data of the patient can be conveniently, timely and accurately acquired, the water drinking and urination habits of the patient with detrusor myasthenia can be standardized, two-stage data of auxiliary urination and autonomous urination can be formed, and the treatment recovery condition of the patient with detrusor myasthenia can be measured by comparing the two-stage data.

The invention provides a nerve monitoring urethral catheterization device and method and application thereof. The device comprises a urethral catheter body, and a first balloon, a detrusor monitoring electrode and a sphincter monitoring electrode are sequentially arranged on the urethral catheter body; a first preset distance is formed between the first balloon and the front end of the catheter body; the detrusor monitoring electrode has a first preset length and a second preset distance from the front end of the catheter body, and is used for collecting an electromyographic signal when the detrusor of a patient contracts; the sphincter monitoring electrode has a second preset length and a third preset distance from the front end of the catheter body, and is used for collecting sphincter contraction / relaxation electromyographic signals of the patient; the myoelectricity equipment is arranged on the supporting table close to the operating table and electrically connected with the positive electrode and the negative electrode of the detrusor monitoring electrode and the positive electrode and the negative electrode of the sphincter monitoring electrode. The purpose of integration of drainage and myoelectricity monitoring is achieved.

The invention relates to the technical field of data processing, and discloses a hydrocephalus assessment method and system based on a bladder pressure dynamic monitoring device. The hydrocephalus assessment method based on the bladder pressure dynamic monitoring device comprises the steps that wrist sympathetic nerve and lumbosacral electromyographic signals are collected and filtered; extracting a specific frequency band power spectrum integral value and a root-mean-square value to fuse and calculate an equivalent bladder pressure value; calculating a detrusor muscle activity index, a compliance index and a night fluctuation coefficient to form a pressure mode; obtaining pressure mode calculation improvement rate judgment reactivity before and after liquid discharge; and calculating a comprehensive improvement index through a weighting algorithm to determine a surgical indication level. The problem that in the prior art, continuous non-invasive monitoring and objective quantitative evaluation cannot be conducted on the bladder function of an iNPH patient is solved, and the accuracy of cerebrospinal fluid drainage test effect evaluation is improved.

The invention discloses a magnetic control urethral catheterization device and a urination control method thereof.The magnetic control urethral catheterization device comprises a urethral catheter, a magnetic control urethral catheterization pump and an in-vitro driver, the urethral catheter comprises a fixing part and a catheter body, the lower end of the catheter body is connected with the magnetic control urethral catheterization pump, and the magnetic control urethral catheterization pump comprises a connecting pipe, an impeller, a brake block and the like; the in-vitro driver is used for driving the magnetic control urinary catheterization pump to be opened and closed. The catheter is anchored to the urethra through the fixing part of the catheter, long-term working stability is guaranteed, the magnetic control catheterization pump is accurately controlled in a non-contact mode through the in-vitro driver, when a patient needs to urinate, only the in-vitro driver needs to be operated, generated magnetic force can drive the in-vivo valve to be opened, urine is guided to be discharged from the urination hole, and the operation is simple and convenient. In the process, bladder emptying is actively completed, the damaged detrusor muscle function is simulated and replaced, and then the problem of urination disorder caused by low activity of the detrusor muscle can be solved.

The utility model discloses a catheter capable of training urethral sphincter, which comprises a catheter main body and an in-bladder one-way water injection pipe, the other end of the in-bladder one-way water injection pipe is communicated with an in-bladder water bag, and the in-bladder water bag is arranged on the surface of the catheter main body; the other end of the one-way water injection pipe in the urethra is communicated with the water bag in the urethra, and the water bag in the urethra is mounted on the surface of the catheter main body; the external expandable balloon is connected with one end, far away from the catheter main body, of the one-way water injection pipe in the urethra, and the external expandable balloon is used for inflating and deflating the water bag in the urethra. According to the technical scheme, the water bag in the urethra can be used for filling according to the inner diameter of the urethra of a patient, so that the conditions of urethra sphincter relaxation, bladder detrusor transition spasm and urine leakage of the patient can be prevented, and the pressure of the water bag in the urethra can be changed, so that the urethra sphincter is trained.

The invention relates to a detrusor muscle contraction stimulation parameter adjusting method and a detrusor muscle contraction stimulation system, and belongs to the technical field of electrical stimulation control, the method comprises the steps that physiological parameters and a treatment period of a current user are acquired, and the physiological parameters comprise the skin electrical impedance quantity, the obesity degree and the age; current pulse parameters of a pulser are determined based on the physiological parameters, so that the pulser emits microwave pulses according to the current pulse parameters, and an electrode device in the detrusor muscle generates induction current according to the microwave pulses emitted by the pulser to stimulate the detrusor muscle; physiological feedback parameters of the current user in the detrusor muscle stimulation process are obtained, wherein the physiological parameters comprise electroencephalogram data and heart rate data; and adjusting the current pulse parameter based on the physiological feedback parameter. The method has the effect of accurately adjusting the parameters according to the condition of the patient.

The application discloses a dysuria and urinary incontinence integrated monitoring and diagnosing system based on intelligent sensing, comprising: a bladder emptying evaluation module for real-time tracking of bladder shape and volume change and evaluation of whether the bladder is completely emptied; a detrusor contraction function evaluation module for real-time monitoring of the contraction strength and coordination of the detrusor and judgment of whether it works normally; a bladder pressure evaluation module for evaluation of bladder compliance and detrusor function by monitoring the elasticity change and pressure change of the bladder wall; a urinary flow rate determination module for real-time measurement of bladder shape change and urinary flow rate and evaluation of the urinary flow rate; a urethral obstruction and bladder outlet obstruction evaluation module for evaluation of whether there is obstruction in the urethra or bladder outlet by real-time monitoring of the shape change and pressure change of the bladder and urethra; and a data analysis and intelligent diagnosis module for providing dysuria diagnosis and treatment suggestion. The application not only improves the accuracy and operability of dysuria diagnosis, but also optimizes the clinical decision-making process.

The invention discloses an intelligent urine collecting device for urology department nursing, relates to the technical field of medical instruments, and aims to solve the technical problem that a patient is in a pathological urination mode for a long time due to the fact that an existing catheter cannot recognize and intervene detrusor sphincter coordination disorder in real time. One end of the catheter arranged in the bladder is provided with a catheterization port and an annular cavity, and the other end of the catheter is provided with an inflation extension tube communicated with an air source; the annular balloon is formed by expanding the annular cavity under the influence of an inflating medium; the inflating hole is formed in the catheter main body and is used for communicating the inflating extension tube with the annular cavity; the air bag internal pressure sensor is fixed on the inner wall of the annular cavity; a dual-pressure real-time monitoring system is constructed, and pressure change signals of detrusor contraction and sphincter areas in the urination period are accurately collected. The defect that the coordination state of the detrusor muscle and the sphincter cannot be sensed in the prior art is overcome, and therefore the upper urinary tract injury risk is effectively reduced.

The invention relates to an application of PINCH2 protein or gene as a target spot in a drug for treating dynamic urinary retention, belongs to the technical field of biomedical engineering, and particularly relates to an application of a substance for regulating PINCH2 protein expression or a substance for regulating PINCH2 protein activity in a drug for treating dynamic urinary retention. According to the invention, a target protein PINCH2 which plays a crucial role in regulation and control of the detrusor of the bladder is found for the first time, and by targeting the PINCH2 protein in the detrusor of the bladder through a drug, the specificity of the drug can be further enhanced, and side effects are reduced.

A medical device, in particular a built-in bladder electro-therapeutic device, which can be placed in the bladder and can regulate bladder functions or relieve urinary tract symptoms by means of electrical stimulation. The technical problem to be solved is that existing bladder nervous regulation devices need surgeries for implantation, need to carry devices out of body, and cannot directly act on the bladder. Provided is a novel therapeutic device which can be placed into the body without a surgery, can be repeatedly placed and removed and can regulate bladder functions by means of electrical stimulation. A main body is of an elastic bendable tubular structure, and a housing is made of an insulating elastic bendable material, so that the therapeutic device can be bent or straightened under an external force, and thus can be completely placed into the bladder through the urethra. A conductive head is provided outside the tubular structure, and a power supply, a discharge module and a central control module are provided inside the tubular structure. The discharge module releases electric pulses by means of the conductive head, the electric pulses emitted by the discharge module act on the inner wall of the bladder via the conductive head to form circuitry, so as to suppress or enhance the feeling of the bladder or the contraction of the detrusor by means of the effect of a current. The central control module can regulate and control the function of the discharge module.

The invention provides a urine flow rate dynamic monitoring system and method, and the method comprises the steps: collecting an ultrasonic image of a bladder neck sagittal section of a target patient, and determining a bladder neck angle of the target patient according to a tangent line of a bladder neck front wall and a bladder neck rear wall in the ultrasonic image; a dynamic change curve of the urine flow rate of the target patient and a pressure change curve of detrusor muscle pressure in the urination process are obtained, and the obstruction index at the bladder outlet of the target patient is determined according to the dynamic change curve and the pressure change curve; constructing a fluid-solid coupling model comprising anatomical structures of the bladder, the prostate and the urethra; based on the fluid-solid coupling model, establishing a collaborative association relationship among the bladder neck angle, the obstruction index and the urine flow rate; and monitoring the urine flow rate of the target patient according to the bladder neck angle and the obstruction index of the target patient and the collaborative association relationship. By adopting the scheme of the invention, the urine flow rate can be dynamically evaluated according to the individualized difference of the bladder of the patient.