48 results about "Bladder capacity" patented technology

Electrical stimulation of specific sensory nerves to control the filling and/or emptying of the urinary bladder. A wireless, injectable microstimulator is implanted into the soft tissues through which the sensory nerves pass, but where they are not normally accessible by conventional open surgical implantation of conventional electrical stimulators or electrodes with leads. In males, the dorsal penile nerves 6 are stimulated by a microstimulator injected into the dorsal quadrant of the penis. The activity induced in these nerves cause the spinal cord to generate reflex responses that result in relaxation of the detrusor muscle, increasing bladder capacity and preventing incontinence as a result of inappropriate bladder contractions. The sensory nerves, such as urethral afferents 4, supplying the urethra are stimulated by a microstimulator implanted into the corpus of the penis, adjacent to the urethra. The activity induced in the urethral afferents 4 cause the spinal cord to generate reflex responses that result in contractions of the detrusor muscle and relaxation of the sphincter 5, emptying the bladder.

The present invention relates to phenyl or heteroaryl amino alkane derivatives of formula (I)

in which the groups Q¹-Q⁴, Ar, and R¹-R⁷ are as defined in the specification and claims. These materials are useful as active ingredients of pharmaceutical preparations. The phenyl or heteroaryl amino alkanes of the present invention have IP receptor antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with IP receptor antagonistic activity. Such diseases include urological diseases or disorders as follows: bladder outlet obstruction, overactive bladder, urinary incontinence, detrusor hyper-reflexia, detrusor instability, reduced bladder capacity, frequency of micturition, urge incontinence, stress incontinence, bladder hyperreactivity, benighn prostatic hypertrophy (BPH), prostatitis, urinary frequency, nocturia, urinary urgency, pelvic hypersensitivity, urethritis, pelvic pain syndrome, prostatodynia, cystitis, or idiophatic bladder hypersensitivity. The compounds of the present invention are also useful for treatment of pain including, but not limited to inflammatory pain, neuropathic pain, acute pain, chronic pain, dental pain, premenstrual pain, visceral pain, headaches, and the like; hypotension; hemophilia and hemorrhage; and inflammation, since these diseases also are alleviated by treatment with an IP receptor antagonist. The application claims the compounds, pharmaceutical compositions containing them, and methods of treatment using them.

The invention relates to a real-time monitoring and alarming system for bladder capacity based on A-type ultrasound, comprising a small A-type ultrasonic pulse transmission receiver, an ultrasonic probe array, a high-speed AD data acquisition part, an ultrasonic signal analysis processing system, a wireless transmission module, a wireless receiving module and a bladder capacity monitoring and alarming system, wherein the ultrasonic probe array sequentially transmits ultrasonic signals, receives echo signals and converts the echo signals into pulse signals under the excitation of the A-type ultrasonic pulse transmission receiver; the echo pulse signal is acquired and stored through AD and then is processed by the ultrasonic signal analysis processing system so as to obtain the diameter of the bladder after being amplified by the A-type ultrasonic pulse transmission receiver; the data is transmitted by the wireless transmission module; the upper level part is provided with a receiving module; after the data is received, the bladder capacity monitoring and alarming system is used for processing and displaying the data; if the set urine volume reaches or exceeds, alarming is carried out; and the upper level part is arranged in a nurse monitoring room. In the invention, the ultrasonic real-time monitoring and wireless alarming system for the bladder capacity can monitor and record the bladder capacity of a patient in real time, not only can be used for detecting the bladder capacity of the patient to provide reference for doctors, but also can be used for monitoring of uracratia patients to reduce the nursing capacity of nursing personnel.

The invention relates to a bladder capacity measuring device and an implementation method thereof. According to the bladder capacity measuring device, a control processor is connected with an image processor; the control output end of the control processor is connected with a probe transmission circuit and a probe driving circuit respectively; the probe transmission circuit and the probe driving circuit are connected with a probe by a probe interface; and the probe is connected with the image processor by a probe receiving circuit. The method comprises the following steps of: controlling a complete machine; controlling the scanning of the probe, so that the probe scans and rotates; controlling the sending and receiving of an ultrasonic signal to generate an ultrasonic digital signal; controlling image processing, so that the ultrasonic digital signal is changed into a type-B ultrasonic image signal which can be displayed; and calculating the capacity of a bladder, namely calculating the capacity of the integral bladder according to the acquired type-B ultrasonic image signal. By the bladder capacity measuring device, the capacity of the bladder can be measured quantitatively without pain, so that the infection of an iatrogenic urinary system is reduced, and the pain of inserting catheters frequently is reduced; and the bladder capacity measuring device is convenient to operate and carry and high in calculation speed, and the patient information, calculation results and images can be stored permanently.

The invention provides a three-dimensioned ultrasonic probe of bladder capacity testers and pertains to the technical field of medical instruments. The three-dimensioned ultrasonic probe of bladder capacity testers comprises a sound transparent film enclosure with a handle, the sound transparent film enclosure is provided with an upper arranged stepper motor which is coordinated and connected with the ultrasonic crystal and is arranged horizontally in the cavity, the handle is provided with a lower arranged stepper motor and a wire connector in the lumen; the upper arranged stepper motor, the lower arranged stepper motor and the ultrasonic crystal are connected with the wire connector by leads; an outer rotor stepper motor is adopted as the upper arranged stepper motor, the outer rotor stepper motor comprises a rotor component and a stator component with a stator shaft, the ultrasonic crystal is connected with the case shell of rotor of the rotor component, the upper arranged stepper motor is arranged on the front bracket by the stator shaft thereof, a front seat fixed with the sound transparent enclosure is arranged at the lower part of the front bracket, the lower arranged stepper motor is arranged vertically and is connected with the lower part of the front seat, and the output shaft of the lower arranged stepper motor is connected with the front bracket. The ultrasonic probe is characterized by simple structure, no noise, long service life and precision in multi-section imaging.

[Problems] A compound useful as an active ingredient for a pharmaceutical composition for treating FAAH-related diseases is provided.

[Means for Solution] The present inventors have made extensive studies on compounds having an FAAH inhibitory activity, and as a result, have found that a piperazine-1-carboxylate compound, in which benzimidazol-2-ylcarbonyl, benzofuran-2-ylcarbonyl or the like binds to the 4-position of the piperazine, has an excellent FAAH inhibitory activity and further has an action to increase the effective bladder capacity, an action to ameliorate sleep disorders, an anti-diuretic action, and an analgesic activity on lower urinary tract pain including bladder pain and the like, thereby completed the present invention. The carbamate compound of the present invention has an excellent FAAH inhibitory activity and can be used as an agent for preventing and/or treating FAAH-related diseases, particularly nocturia, interstitial cystitis, painful bladder syndrome, or chronic non-bacterial prostatitis/chronic pelvic pain syndrome.

The invention relates to a bladder capacity determination and three-dimensional shape evaluation method and system special for radiotherapy. The method comprises the following steps: 1, adopting an ultrasonic diagnosis probe to emit ultrasonic waves to the abdomen of a human body under the action of high-frequency electric pulses; receiving echo signals emitted by the organ wall of the human body, analyzing image information through a processing terminal according to the echo signals, and acquiring a current bladder capacity value according to image information in combination with a bladder instrument of a neural network harmonic technology; 2, collecting ultrasonic image information during simulated positioning and ultrasonic image information before each treatment for reinforcement learning registration training to obtain a model which is used for guiding rapid registration of ultrasonic images of a subsequent new patient; 3, after registration, calculating a dice similarity coefficient DSC of a bladder image A during positioning and a bladder image B before each treatment; and 4, collecting the bladder capacity value and corresponding DSC data, establishing a one-to-one corresponding data set, and carrying out comparative analysis to obtain an optimal bladder capacity value so as to guide subsequent treatment.

The invention discloses a bladder irrigation connecting pipe which comprises a connecting pipe body. One end of the connecting pipe body is provided with a catheter connector connected with a human body catheter. The other end of the connecting pipe body is provided with a puncture needle. A dripping bucket and a water stop device are sequentially arranged between the puncture needle and the catheter connector. The portion, between the water stop device and the dripping bucket, of the connecting pipe body is a silicone tube. The portion, between the water stop device and the catheter connector, of the connecting pipe body is connected with a detection catheter for detecting bladder pressure through a tee joint. The portion, between the tee joint and the catheter connector, of the connecting pipe body is connected with a urine bag connector through a three-way plug valve. By means of matching of the silicone tube arranged between the water stop device and the dripping bucket and a rolling wheel of a special device(bladder capacity evaluating system), pump type liquid supply is achieved; the catheter connector and the urine bag connector are connected through the three-way plug valve, urine in the bladder in a patient can be conveniently voided, liquid drainage after irrigation is convenient, and convenience is brought to operation of medical staff.

The invention relates to a turbo-type bladder flushing device. The device comprises a flushing bag, a catheter A, a catheter B, a catheter C, a catheter D, automatic control systems, bladder capacitymonitoring systems, a three-cavity urine guiding pipe and a liquid collecting bottle; the inside of each automatic control system is provided with a programmable logic controller (PLC), a MM440 frequency converter, a motor and a suction blade; each PLC controller comprises seven modules including a central processing unit, a storage, a programmer, an external equipment interface, an input interface, an I/O expansion interface and an output interface; each bladder capacity monitoring system is composed of a main engine, a cylinder and a pressure gauge; the head of the three-chamber urine guiding pipe is provided with an expansion balloon; and the tails of the three-chamber urine guiding pipe are effectively provided with an injection valve, an input valve and an output valve. The advantagesof the turbo-type bladder flushing device are as follows: a suction effect is achieved for patients with formed intravesical blood clots; operation is simple, and pain of patients is relieved; a turning wheel can exert an effect to remove blood clots mechanically, and a turbine will not injure a bladder; capacity of the bladder and internal pressure can be detected through the design of bladder capacity monitoring systems; and the safety factor is increased.

The invention discloses a method and system for monitoring bladder capacity. The method includes: applying ultrasonic waves to the human body; receiving echo signals transmitted back from the walls of human body organs, and converting them into digital amplitude signals after processing; The signal is analyzed to obtain the information image, and the current bladder volume value is obtained according to the information image; it is determined that the current bladder volume value is greater than the bladder safety capacity value, and an alarm signal is issued. The present invention acts on the human body through ultrasonic waves, receives the echo signal reflected by the human body, analyzes and processes the echo signal to obtain an information image, and then analyzes the current bladder volume value from the information image, so that according to the current bladder volume value and The comparison of bladder safety capacity values ​​determines whether to send an alarm signal to the voiding disorder to remind the voiding disorder to urinate, to achieve an early warning effect, to ensure the safety of the patient, and to avoid complications such as bladder-ureteral reflux and hydronephrosis.

The invention belongs to the technical field of medical instruments and apparatuses and particularly relates to a wearable non-invasive bladder capacity monitoring and alarming device. The device comprises a bladder bioelectrical impedance monitoring and collecting device and an upper computer for real-time display; the bladder bioelectrical impedance monitoring and collecting device is used for continuously collecting the bioimpedance of the bladder of a patient in real time and judging whether the patient reaches a bladder capacity threshold value or not, and comprises a lead wire, a disposable electrode, a high-precision impedance converter and a control and transmission mainboard. The high-precision impedance converter and the control and transmission mainboard are small in size and lightweight and do not influence the normal life of the patient. By monitoring a bladder impedance value which is sent back from a main control board through a serial port in real time, the upper computer realizes real-time and continuous monitoring of the bladder biological impedance and provides convenience for professional medical staff to carry out impedance calibration and set an impedance threshold value. The device helps to improve the life quality of patients with bladder and urethra dysfunction and helps the patients to recover the autonomous urination function.

The invention discloses a training bed for treating a patient suffering from neurogenic bladder. The training bed comprises a bed body framework, a bed plate, a bed pan, a funnel, a spray nozzle, an adjustable fixing rod and a capacity measurement bag, wherein the bed plate is put on the bed body framework and comprises an upper plate, a middle plate, a lower plate, a rocker system and a hand crank, the upper plate, the middle plate and the lower plate are fixed through hinges, the rocker system is arranged at the lower part of the bed plate, and the hand crank is connected with the rocker system to control the upper plate, the middle plate and the lower plate; the bed pan is embedded in the lower plate, a water outlet is formed in the lower part of the bed pan and connected with a guide pipe, and the guide pipe is connected with the capacity measurement bag; the adjustable fixing rod is arranged on one side of the bed body framework, the funnel is fixed at the top of the adjustable fixing rod, and the lower part of the funnel is connected with the spray nozzle through a pipeline. The training bed is novel in structure and convenient to use, makes the patient feel comfortable when the bladder capacity of the patient suffering from neurogenic bladder is trained and measured, can ensure that a measured liquid leaks into a urine receiving container and can accurately measure the capacity and clean the perineum of the patient after capacity measurement, and accordingly, infection is reduced.

[Problem] Provided is an agent for preventing or treating diseases accompanied by urinary pain.

[Means for Solution] A pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound or a salt thereof was confirmed to have not only an action of increasing effective bladder capacity but also an analgesic action against bladder pain and testis pain, based on FAAH inhibitory action. Accordingly, the pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound or a salt thereof can be used for preventing or treating interstitial cystitis/bladder pain syndrome and/or chronic nonbacterial prostatitis/chronic pelvic pain syndrome.

The present invention relates to carboxamides which are useful as an active ingredient of pharmaceutical preparations. The carboxamides of the present invention have IP receptor antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with IP receptor antagonistic activity. Such diseases include urological diseases or disorder as follows: bladder outlet obstruction, overactive bladder, urinary incontinence, detrusor hyper-reflexia, detrusor instability, reduced bladder capacity, frequency of micturition, urge incontinence, stress incontinence, bladder hyperreactivity, benighn prostatic hypertrophy (BPH), prostatitis, urinary frequency, nocturia, urinary urgency, pelvic hypersensitivity, urethritis, pelvic pain syndrome, prostatodynia, cystitis, or idiophatic bladder hypersensitivity. The compounds of the present invention are also useful for treatment of pain including, but not limited to inflammatory pain, neuropathic pain, acute pain, chronic pain, dental pain, premenstrual pain, visceral pain, headaches, and the like; hypotension; hemophilia and hemorrhage; and inflammation, since the diseases are alleviated by treatment with an IP receptor antagonist.

The invention discloses a traditional Chinese medicine for the treatment of frequent nocturnal micturition and a preparation method and applications thereof. The traditional Chinese medicine comprises the following raw materials in parts by mass: 15-28 parts of radix polygoni multiflori, 8-12 parts of fructus rosae laevigatae, 8-15 parts of semen plantaginis, 15-25 parts of rhizoma polygonati, 15-30 parts of rhizoma gastrodiae, 10-18 parts of cassia bark, 18-25 parts of radix clematidis, 20-27 parts of astragalus membranaceus, 15-25 parts of lily roots, 18-28 parts of radix polygalae, 1 part of lumbricus and 1 part of buthus martensi kirsch. The preparation method comprises the steps of frying lumbricus, processing buthus martensi kirsch with rice vinegar, crushing, soaking, sequentially carrying out water extraction and mixed drying, and molding. The traditional Chinese medicine disclosed by the invention has the effects of warming the kidney, dispelling cold, strengthening the brain, promoting mentality, inducing resuscitation, reinforcing the kidney, regenerating bone marrow, and preventing enuresis, and can accelerate the general blood circulation, dredge urinate nerve centre channels and collaterals between the brain and the urinary bladder, and improve the urinate sensitivity of the brain; and the traditional Chinese medicine adjusts the contraction and stretching of detrusor of bladder, expands the bladder capacity, and reduces the number of micturition times, thereby effectively treating the frequent nocturnal micturition of children, adolescents and old people.

The invention discloses an oral electronic examination instrument which simplifies the disinfection procedure. An elastic part is arranged between the upper tweezers arm and the lower tweezers arm. A battery is arranged in the tweezers handle. , the lamp is further set on the upper part of the fixed rod, the upper end of the tweezers handle is provided with a container, the two sides of the container are provided with amalgam fillers and zinc tin fillers, the container is provided with a connecting terminal, and the tweezers handle is provided with a liquid channel , the connecting end is sleeved on one end of the liquid channel, the liquid channel is further connected to the branch channel, and one end of the upper tweezers arm and the lower tweezers arm are provided with tweezers heads, and scale marks are provided on the tweezers heads. The invention provides an oral electronic examination instrument with simplified disinfection procedures, which is safe and hygienic, has simplified disinfection procedures, has various functions, is convenient to use, is easy to operate, meets the use requirements, and has strong practicability.

The invention discloses a quality control detection training phantom for a bladder capacity measuring instrument and a manufacturing method of the quality control detection training phantom and belongs to the bladder capacity measurement field. The quality control detection training phantom comprises a simulated human body pelvic cavity model and a plurality of bladder inserts; the simulated humanbody pelvic cavity model is provided with insertion openings for accommodating the bladder inserts; and simulated bladders of different capacities and shapes are arranged in the bladder inserts. Themanufacturing method includes a 3D printing file generating step, a printing step, a simulated human body pelvic cavity model casting step and a bladder insert casting step. The quality control detection training phantom can be used to accurately monitor the training operation of bladder capacity measurement and meet the accuracy, repeatability, linearity and other indicators of an ultrasound bladder capacity measuring instrument during radiotherapy.

The invention discloses a measuring scale for measuring bladder capacity and pressure, and belongs to the technical field of medical products. The measuring scale can be used for measuring the bladdercapacity and pressure of a patient and judging the change conditions of the bladder capacity and pressure of the patient, and has the characteristics of convenience in use, simplicity in operation and control, practicability and the like. The measuring scale comprises a scale body, wherein a fixed groove is formed in the scale body in the extending direction of the scale body; an L-shaped plate is arranged beside the fixed groove; a rotating shaft, an angle scale and a rotating needle are arranged on the L-shaped plate; one end of the rotating shaft is fixedly connected with the L-shaped plate, and the other end of the rotating shaft is fixed to the circle center of the angle scale; the rotating needle is rotationally arranged on the rotating shaft; a positioning mechanism is arranged onthe rotating needle; two pin holes matched with the positioning mechanism are formed in the upper portion of the L-shaped plate; the two pin holes are located in a 90-degree projection and a -90-degree projection of the angle scale respectively; and a buckle is arranged on the rear portion of the scale body.

The invention discloses an application of an adenosine receptor antagonist in preparation of a medicine for treating bladder and urinary dysfunction of mammals. The adenosine receptor antagonist can effectively increase bladder capacity and reduce urination frequency.