35 results about "Bladder capacity" patented technology

The invention provides a bladder EIT three-dimensional shape real-time reconstruction and capacity measurement method based on deep learning, and belongs to the technical field of deep learning, and the method comprises the steps: generating a three-dimensional abdomen simulation model according to a collected three-dimensional CT image, and constructing a bladder EIT data set containing abnormal conditions; acquiring bladder position information according to the three-dimensional abdomen simulation model to construct a loss function containing position regularization, taking EIT measured values in the bladder EIT data set as input of a deep learning network, establishing a mapping relation between the EIT measured values and bladder morphology, and storing a trained network model; and taking the EIT measurement value of the actual patient as the input of the trained network model, performing real-time comparative analysis on the obtained bladder capacity of the patient and the bladder capacity calculated by the CT true value of the patient in the radiotherapy process, and performing real-time optimization and correction on the bladder capacity of the patient. The three-dimensional shape of the bladder can be accurately reconstructed without depending on the traditional image technology, and the measurement of the bladder capacity is optimized in real time.

The utility model provides a wireless and rechargeable bladder pacemaker for monitoring bladder capacity, and relates to the field of medical instruments. The utility model provides a wireless and rechargeable bladder pacemaker for monitoring bladder capacity. The wireless and rechargeable bladder pacemaker comprises a rechargeable current stimulator, a plurality of groups of stimulation mechanisms and a plurality of piezoelectric films, wherein each group of stimulation mechanism comprises two bladder stimulation units; the bladder stimulation unit and the piezoelectric film are respectively connected with the current stimulator through leads; the two bladder stimulation units and the current stimulator in each group of stimulation mechanism are arranged on the surface of the bladder, and the piezoelectric film is arranged in the wall of the bladder. According to the utility model, the volume of liquid in the bladder of a patient can be obtained in real time, the bladder detrusor muscle can be stimulated and induced to contract to complete urination, and most importantly, the stimulation and induction mode of the bladder detrusor muscle does not need the participation of human body movement efferent nerves; the piezoelectric film can convert contraction tension or expansion tension of the bladder wall into electric energy to supply power to the current stimulator.

A bladder volume measuring method is disclosed. The measuring method is applied to a measuring device, the measuring device includes a detector for acquiring a sectional image of a bladder and rotatable around a first direction, and the first direction is a direction of a connecting line between the detector and a measured position. The measuring method includes: when the detector rotates around the first direction, acquiring a corresponding initial sectional image every time the detector rotates by a first preset angle; confirming a current position of the bladder according to all the initial sectional images, and generating and displaying corresponding prompt information; the prompt information being used for prompting a user to move the detector; and after the detector moves, when the detector rotates around the first direction again, acquiring a corresponding current sectional image at an interval of a second preset angle to calculate the bladder volume.

The invention relates to the field of antibodies, in particular to a monoclonal antibody for treating overactive bladder and application of the monoclonal antibody. The monoclonal antibody specifically recognizes and is combined with an adrenergic receptor beta3 (ADR beta3), the monoclonal antibody is obtained through a hybridoma technology, and the M13 monoclonal antibody with high affinity is successfully screened out. The M13 antibody promotes the increase of cAMP concentration in smooth muscle cells and activates a PKA pathway by activating an ADR beta3 receptor, thereby promoting the relaxation of bladder smooth muscles, increasing the bladder capacity and reducing the non-autonomous contraction of detrusor muscles. Animal experiments prove that the M13 monoclonal antibody can effectively improve the urination frequency and urine volume of a mouse OAB model, and has a good clinical application prospect. The monoclonal antibody and the preparation method thereof can be widely applied to the field of treatment of overactive bladder.

The utility model relates to medical supplies technical field, concretely relates to a simple bladder capacity determination device, solves the problem that the part assembly of current catheterization is inconvenient and physiological saline temperature is not suitable and will irritate bladder, including the hanging plate, the front side of hanging plate is fixed with physiological saline loading bag, water column pipe and adjustable tee bend valve, the lower extreme of water column pipe inserts into adjustable tee bend valve, the liquid outlet of physiological saline loading bag is fixed with the water pipe, the other end of water pipe inserts into adjustable tee bend valve, the other end of adjustable tee bend valve inserts into the external connection pipe, and the physiological saline loading bag is covered with heating mechanism, the utility model can improve the inconvenient shortcoming of clinical bladder capacity determination device part assembly, improve work efficiency, and heating mechanism can heat physiological saline loading bag, and the temperature of physiological saline is kept stable after heating, reduces the irritation of low temperature to bladder.

The present invention belongs to the technical field of urinary catheters; specifically, it is a urinary catheter intelligent control opening and closing system, which includes a urinary catheter, an air inlet tube and a urination main body. The invention improves the existing urinary catheter and optimizes the setting of the urination main part. When the pressure sensor detects a pressure greater than 60cm of water column, it opens and when it is less than 20cm of water column, it closes to achieve the function of automatic opening and closing. Then, the servo motor drives the worm and worm gear to rotate so that the disc-shaped baffle cooperates with the arc-shaped sealing strips on both sides, controlling the automatic opening and closing of the channel in the catheter, maintaining the bladder capacity and restoring the bladder's contraction function, thereby ensuring the patient's health. At the same time, a through hole close to the urination end and inclined toward the urination end is arranged in the catheter. The through hole is closed and opened by a shielding component. After closing, urine is prevented from flowing out. After opening, flushing liquid is introduced to comprehensively and effectively clean the inside of the catheter, avoiding residual urine and breeding bacteria, further improving the safety of use.

The invention relates to the field of artificial urethral sphincter, in particular to a self-adaptive artificial urethral sphincter based on bladder capacity monitoring, comprising: a urethral closure unit for applying dynamically adjustable closure pressure on the urethra of a patient; the bladder monitoring unit is used for dynamically monitoring parameters related to the bladder filling state of the patient and generating a signal indicating the bladder filling state; and the implantable control unit is connected with the urethra closing unit and the bladder monitoring unit and is configured to receive the signal from the bladder monitoring unit and dynamically adjust the closing pressure applied to the urethra by the urethra closing unit according to the bladder filling state indicated by the signal. According to the embodiment of the invention, through intelligent adjustment of pressure application according to needs, the urethral tissue can bear high pressure only when the bladder is full or other necessary conditions are needed, and is in a low-pressure state for a long time, so that the total pressure load is reduced, and tissue atrophy and erosion caused by long-term ischemia are prevented.

The invention provides an intelligent bladder volume control method, device and equipment based on bladder pressure monitoring, belongs to the technical field of data processing, and aims to solve the problem of poor precision of keeping the current bladder volume constant, adaptive bladder diversion control can be carried out according to the urine increment rule of a target patient after drinking water, and the accuracy of bladder volume control is improved. The volume of urine in the bladder can be always kept within a certain interval, so that the pressure in the bladder can be prevented from being too high, and the keeping precision of the bladder capacity can be improved to a certain extent.

The invention provides a urination early warning method and system for time sequence prediction based on a large language model, and the method at least comprises the following steps: S1, collecting bladder volume dynamic change data through a urine volume collection terminal in a non-contact manner, and transmitting the data to a mobile terminal APP through a Bluetooth transmission unit; s2, preprocessing the original volume data acquired by the urine volume acquisition terminal through the mobile terminal APP, and recording static characteristics of a user; s3, carrying out feature fusion on the preprocessed volume time sequence data and static features through a large language model prediction server, constructing a three-dimensional input matrix, carrying out prediction reasoning by utilizing a pre-trained large language model, and outputting a future urination time point; and S4, triggering early warning and reminding according to the prediction result and the real-time bladder capacity. The system at least comprises a urine volume collection terminal, a mobile terminal APP and a large language model prediction server. According to the method and the system, accurate prediction of the urination time in the future is realized through deep learning of individual historical data by a large language model.

The application discloses application of metformin in preparation of a medicine for treating interstitial cystitis, and finds that metformin can reduce pain sensitivity of an interstitial cystitis (IC) rat, reduce edema degree of a bladder of the IC rat, restore bladder capacity of the IC rat, repair the bladder mucosa of the IC rat and reduce submucosal hemorrhage, reduce mast cell infiltration, and has a significant curative effect on interstitial cystitis, and can provide a new medicine for treating interstitial cystitis.

The utility model discloses a fixable bladder capacity measuring device, and particularly relates to the technical field of medical equipment, the fixable bladder capacity measuring device comprises a scaleplate, an infusion bottle, a Y-shaped catheter and an infusion support, the front end of the scaleplate is provided with a semicircular hard pipeline protruding outwards, the semicircular hard pipeline is of a cavity structure, the semicircular hard pipeline is provided with scales, and the Y-shaped catheter is provided with an infusion support. The back face of the scale plate is fixed to the infusion support through a fixing structure, an infusion bottle is installed on a hook of the infusion support, a Y-shaped catheter is installed at the lower end of the infusion bottle and composed of an infusion tube, a long tube and a connecting tube, the upper end of the infusion tube is connected with the bottom end of the infusion bottle, and the lower end of the infusion tube is connected with the long tube and the connecting tube. One end of the long pipe penetrates through the semicircular hard pipeline and extends to the position above the semicircular hard pipeline. According to the utility model, the scale plate is convenient to fix and is prevented from shaking, and corresponding bladder pressure data is read through the scales on the semicircular hard pipeline, so that the bladder capacity measurement result is more accurate.

The invention discloses a bladder morphology measuring method and device, electronic equipment and a storage medium, and relates to the technical field of ultrasonic noninvasive detection and medical image processing. The method comprises the following steps: extracting an effective echo sequence based on an ultrasonic signal, fitting a bladder form according to spatial arrangement characteristics of three-dimensional discrete point cloud coordinate information, and optimizing fitting parameters by adopting a least square method and a Newton iteration method; performing breathing follow-up compensation processing on the initial geometric model, and dispersing the initial geometric model after breathing compensation obtained after processing into an elastic network model of a topological structure so as to perform local elastic deformation optimization; determining the geometric volume of the bladder according to the elastic correction curved surface by adopting a voxel division method; and performing weighted correction according to the individual correction coefficient and the geometric volume of the bladder to obtain the bladder capacity so as to realize measurement of the bladder form. The method can be applied to bladder capacity calculation of the flexible ultrasonic patch, and the accuracy of capacity calculation is improved.

The invention discloses an application of metformin in preparation of a medicine for treating interstitial cystitis, and finds that the metformin can reduce the pain sensitivity of an interstitial cystitis (IC) rat, reduce the bladder edema degree of the IC rat, recover the bladder capacity of the IC rat, repair the bladder mucosa of the IC rat and reduce submucosal bleeding. Macrocyte infiltration is reduced, that is, the metformin has a remarkable curative effect on interstitial cystitis, and a new medicine can be provided for treating interstitial cystitis.

Embodiments disclosed herein are directed to a self-learning bladder volume monitoring system. The system can include a bladder volume (BV) system configured to measure an electrical impedance of a bladder region of a patient and determine a volume of fluid disposed therein using an impedance to bladder volume model (“By model”). Further, the system can measure a total body water (“TBW”) for the patient and modify the BV model to account for variations in TBW within the tissues surrounding the bladder providing a more accurate bladder volume measurement. The system can include a “training unit” which can include one of a user input interface, an automatic urine output monitoring system, an ultrasound system, and an intrabladder pressure system configured to verify a volume of fluid within or voided from the bladder and train the BV model.

A bladder volume measuring device includes a feature providing unit, a parameter determining unit, and a volume calculating unit. The feature providing unit may provide a plurality of feature factors for calculating a volume of a bladder included in an ultrasound image. The parameter determining unit may determine a selection parameter corresponding to some of the feature factors. The volume calculating unit may calculate the volume of the bladder according to the selection parameter. The bladder volume measurement device using parameter extraction according to the present invention may extract an optimal selection parameter using a parameter determining unit machine-learning a plurality of feature factors extracted to calculate a volume of a bladder included in an ultrasound image and measuring the volume of the bladder based on the selection parameter, thereby more accurately measuring the bladder volume.

The invention discloses a double-target inhibitor aiming at PIEZO1 and NLRP3 and application of the double-target inhibitor in bladder dysfunction after pelvic tumor operation, based on the pathological mechanism that PIEZO1 is abnormally activated due to postoperative mechanical stimulation, Ca < 2 + > influx increase is caused, and NLRP3 inflammasome is further activated, PIEZO1 inhibiting polypeptide GsMTx4 and NLRP3 small-molecule inhibitor MCC950 are compounded according to a certain mass ratio, and the PIEZO1 inhibiting polypeptide GsMTx4 and NLRP3 small-molecule inhibitor MCC950 are compounded according to a certain mass ratio. A temperature-sensitive hydrogel sustained release preparation capable of being locally injected into the bladder is constructed, and dual-channel synergistic inhibition is achieved; animal experiments show that the composition can significantly reduce the expression level of IL-1beta, inhibit the peak amplitude of Ca < 2 + >, reduce the inflammation score and fibrosis area proportion, improve the residual urine volume and bladder capacity, and reduce the system exposure level and the risk of abnormal liver and kidney functions; the technical scheme has a clear mechanism basis and good safety, and is suitable for local intervention of postoperative bladder dysfunction.

According to the bladder volume measuring device according to the present invention, it is possible to more accurately measure the amount of urine contained in the bladder by calculating the bladder volume according to the first straight line and the second straight line crossing the inside of the bladder region included in the cross-sectional image including the bladder.

The utility model discloses a handheld bladder volume meter host moving support, which belongs to the technical field of bladder volume meters and comprises a moving component, and a rotating component is mounted at the upper end of the moving component. The rotating assembly comprises a connecting block, a bearing, a connecting rod, a mounting plate and a limiting assembly; fixing assemblies are mounted on the left and right sides of the upper end of the rotating assembly; a detection assembly is installed at the upper end of the rotating assembly. By means of the mode, the movable support can be moved through the pull rod, the button is connected to the pull rod in a sliding mode, medical staff can rotate the installation plate more conveniently, the installation plate can rotate, the support can detect a patient in a narrow place, the tooth block is meshed with the first gear, locking of the installation plate is achieved, and the operation is convenient. The mounting plate is prevented from rotating when not needing to rotate; the probe can be fixed, and the sterilizing lamp located at the bottom of the cylinder can sterilize the end of the used probe, so that cross infection is prevented.

The utility model discloses a bladder capacity pressure measuring device which comprises a base, a fixing cylinder is arranged on the upper surface of the base, a movable lifting rod is connected in the fixing cylinder in a sliding mode, a first positioning bolt is installed in a threaded hole in the circumferential face of the fixing cylinder, and a height-adjustable installation frame is installed at the upper end of the movable lifting rod. According to the bladder capacity pressure measuring device, the scale, the glass tube, the infusion strap connector, the Y-shaped connector, the infusion tube and the infusion bottle can be conveniently protected and fixed by arranging the protective cover, the opening and closing groove and the positioning groove, external collision is avoided, the accuracy of the measuring result is guaranteed, meanwhile, the situation that a patient is pulled due to shaking of a pipeline is prevented, and the working efficiency is improved. By arranging the first positioning bolt and the second positioning bolt, the height of the measuring device can be conveniently adjusted and fixed, parts of the measuring device can be conveniently protected and fixed, the accuracy of a measuring result is guaranteed, and the height of the measuring device can be conveniently adjusted according to actual conditions.

According to the technical scheme, the catheter capable of achieving the constant bladder capacity is characterized in that the catheter comprises a catheter body, the catheter body comprises an inner pipeline, an outer pipeline and an insertion body, the head ends and the tail ends of the inner pipeline and the outer pipeline are closed to form an interlayer cavity, a through hole is communicated with the inner pipeline, a small balloon is arranged on the outer pipeline, and the small balloon is communicated with the insertion body. The outer pipeline is provided with a first injection pipe, the first injection pipe is communicated with the small balloon through the interlayer cavity, the guide pipe body is provided with a large balloon, the outer pipeline is provided with a second injection pipe, and the second injection pipe is communicated with the large balloon through a connecting pipe; the small balloon and the large balloon are arranged on the catheter body, after the catheter body is placed into the bladder, a certain amount of liquid needs to be injected into the small balloon before radiotherapy to achieve the effect of fixing the catheter body, and a certain amount of air or normal saline is injected into the large balloon during radiotherapy every time, so that the constant bladder capacity is achieved; therefore, the radiotherapy accuracy is improved, and the radiotherapy treatment effect is improved.

Methods and systems for ultrasound-based urodynamic evaluation are presented in the present disclosure. Pre-void and post-void ultrasound data of a bladder is acquired, in addition to a dynamic acquisition during voiding on a sagittal plane that encompasses the bladder, bladder neck and proximal urethra. The dynamic acquisition may be an ultrasound cine scan or a uroflowmetry measurement during voiding. Using semiautomatic segmentation, the volumes are quantified and virtual models are generated. Similarly, the ultrasound cine sagittal images are segmented to determine the deformation pattern of the bladder during voiding. Using an algorithm, a volume interpolation between pre and post void volumes is performed using the deformation profile obtained from the dynamic sagittal images as a constraint. Resolved bladder volumes are then analyzed using a computational fluid dynamics algorithm to derive flow rates and pressures and to calculate indices of contractility (BCI) and bladder obstruction (BOOI).

The invention provides a noninvasive bladder function monitoring method and system based on time sequence prediction, and the method comprises the steps: training a bladder pressure prediction model based on the clinical data of a patient and the UDS examination data of the patient; obtaining water drinking urethral catheterization data, heart rate and environment temperature and humidity of a patient to be monitored, and inputting the data into the trained urine generation rate prediction model to obtain real-time bladder volume data; and inputting the clinical data of the to-be-monitored patient and the predicted bladder volume data into the bladder pressure prediction model to obtain a bladder pressure prediction value of the to-be-monitored patient. By collecting UDS images and diagnoses of a large number of patients and combining clinical data of the patients, drinking urine catheterization data, heart rate and environment temperature and humidity, the prediction model is trained, the bladder pressure of the patients at different disease stages and under different bladder filling degrees is predicted, a non-invasive AI UDS monitoring means is provided for the patients, and the accuracy of bladder pressure monitoring is improved. And a patient is helped to better manage the bladder in a home state.

The invention discloses a rehabilitation evaluation method for a urine control neural circuit function and a readable storage medium, and the method comprises the steps: collecting a standard state electrophysiological signal and a dynamic process electrophysiological signal of a user; extracting multi-dimensional features of the standard state electrophysiological signal and the dynamic process electrophysiological signal to obtain a standard state electrophysiological signal feature vector and a dynamic process electrophysiological signal feature vector of the user; according to the standard state electrophysiological signal feature vector of the user, a preset dichotomy model is adopted to calculate a dichotomy accuracy index of the user, according to the dynamic process electrophysiological signal feature vector of the user and a preset health baseline range, a dynamic process index of the user is calculated, and a physiological index of the user is calculated. Calculating a full bladder capacity index of the user; according to the physiological index, the dichotomy accuracy index, the dynamic process index and the full bladder capacity index of the user, the rehabilitation score of the urine control neural circuit function of the user is obtained through calculation.

The application provides a kind of based on deep learning bladder EIT three-dimensional topography real-time reconstruction and capacity determination method, belong to deep learning technical field, including: according to the three-dimensional CT image generated three-dimensional abdominal simulation model, construct the bladder EIT data set containing abnormal situation;According to the three-dimensional abdominal simulation model, obtain the bladder position information and construct the loss function containing position regularization, and the EIT measurement value in bladder EIT data set is as the input of deep learning network, the mapping relationship between EIT measurement value and bladder topography is established, and the network model after training is saved;The EIT measurement value of actual patient is as the input of network model after training, and the bladder capacity obtained by patient is compared and analyzed in real time with the bladder capacity calculated by CT true value in radiotherapy process, and the bladder capacity of patient is optimized and corrected in real time.Can be accurately reconstructed the three-dimensional topography of bladder without relying on traditional imaging technology, and the determination of bladder capacity is optimized in real time.

A bladder volume monitoring system based on Advanced Reduced Instruction Set Computing Machines (ARM), characterized in that it comprises: a three-chamber urinary catheter (2), an air supply channel (26), a fluid supply channel (25), and a fluid drainage channel (27); wherein one end of the three-chamber urinary catheter (2) is positioned inside a bladder (24) during use, and the other end of the three-chamber urinary catheter (2) is provided with three openings, each being an air opening (21), a fluid supply opening (22), and a fluid drainage opening (23); wherein the air inlet end of the air supply channel (26) is connected to an external air source, and the air outlet end of the air supply channel (26) is connected to the air opening (21);wherein the fluid inlet end of the fluid supply channel (25) is connected to an external fluid container and the fluid outlet end of the fluid supply channel (25) is connected to the fluid supply port (22); wherein the fluid inlet end of the fluid drainage channel (27) is connected to the fluid drainage port (23) and the fluid outlet end of the fluid drainage channel (27) is connected to an external container; wherein the end of the three-chamber urinary catheter (2) located inside the bladder (24) is provided with several three-chamber urinary catheter fluid inlet ports (22a) connected to the fluid supply port (22) and a three-chamber urinary catheter fluid drainage port (23a) connected to the fluid drainage port (23);wherein the end of the three-chamber urinary catheter (2) located inside the bladder (24) is further equipped with a balloon (20), and the balloon (20) is connected to the air opening (21); wherein a sensor (16) is arranged on the fluid supply channel (25), and the sensor (16) serves to monitor the pressure in the fluid supply channel (25) in order to determine the pressure in the bladder (24).

The invention relates to the technical field of medical instruments, in particular to a flexible strain sensor and a bladder capacity monitoring system.The flexible strain sensor is attached to the surface of the bladder and used for generating deformation according to expansion or contraction of the bladder wall and converting the deformation into an electric signal; the flexible strain sensor comprises a flexible substrate layer, a conductive material layer and a packaging layer, the flexible substrate layer is made of platinum-catalyzed organic silicon rubber (Ecoflex-0050), the modulus of the flexible substrate layer is matched with that of bladder tissue, the thickness of the flexible substrate layer is 500 microns, and the flexible substrate layer can generate synchronous deformation along with expansion and contraction of the bladder; the conductive material layer is prepared by mixing a carbon nanotube (CNT) and Ecoflex-0050 according to the proportion of 5wt%, the thickness of the conductive material layer is 100nm, and the conductive material layer is uniformly coated on the surface of the substrate layer to form a stretchable conductive network; the material of the packaging layer is Ecoflex-0050, and the thickness of the packaging layer is 200 [mu] m. The flexible strain sensor and the bladder capacity monitoring system provided by the invention aim to meet the requirements of good biocompatibility, high sensitivity and real-time bladder capacity detection.

1. The name of this design product: Portable bladder capacity measuring instrument. 2. Purpose of this design product: Used in medical clinical practice to non-invasively measure the urine capacity of a patient's bladder. 3. The key design point of this design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The invention provides a bladder capacity accelerated measurement method based on an FPGA. The method comprises the steps that a bladder ultrasonic image is obtained, left and right extreme points of the lower wall of the bladder ultrasonic image are positioned, bladder wall adduction inspection is completed, and the adduction points are merged into a boundary point array; adopting a Bresenham straight line algorithm to set 8-bit gray values of pixel positions where all boundary points in the boundary point array are located as 255, generating a closed bladder area contour, and packaging a bladder area contour detection algorithm into an edge detection IP core; based on the edge detection IP core, a lightweight U-Net capacity measurement IP core is adopted to carry out capacity measurement; wherein the lightweight U-Net is an optimized U-Net network, and comprises the steps of performing spatial selective suppression on a feature map extracted by the U-Net network by adopting pixel information based on a bladder contour in a bladder ultrasound image, introducing residual connection to a jump connection part, enhancing gradient flow and suppressing artifacts; in the process of measuring the bladder capacity, end-to-end bladder capacity measurement is completed by combining an input channel, an output channel and a pixel parallel three-dimensional calculation structure of a network model; according to the method, dynamic threshold calculation based on the local neighborhood of the core point and an extreme point screening rule are combined, and the problem that a traditional algorithm is easily interfered by ultrasonic noise and surrounding tissues is solved.

The invention discloses nano-silver polyphenol-recombinant humanized collagen bionic gel for interstitial cystitis, belongs to the field of biomedical materials and regenerative medicine, and particularly relates to a novel biomedical composite gel material. Especially aiming at the pathological characteristics of interstitial cystitis IC, silver nanoparticles, a surface polyphenol network and PDA-amine functionalized combination III type recombinant humanized collagen and a sodium alginate matrix are crosslinked through EDC / NHS or Genipin to construct a stable sustained-release system; the prepared gel shows excellent antibacterial activity, cytocompatibility, appropriate rheological properties and swelling rate in vitro, is controllable in degradation half-life period, can significantly improve frequent urination, reduce inflammation score and recover bladder capacity in an animal model, and is suitable for cystitis local perfusion treatment.