1315results about "Internal electrodes" patented technology

Devices and methods to mitigate the erroneous signal imparted by physical and / or chemical process incident upon analyte-selective electrochemical sensors that are non-analyte-related in origin are disclosed herein. A sensing system featuring at least one of an analyte-selective sensor and at least one of an analyte-invariant sensor.

The present invention provides systems and methods for treatment planning and / or administering electrical pulses that elicit desired cell death mechanisms. Embodiments of the invention include selection of pulse parameters to tailor cell death type.

In one aspect, methods of treating skin are described herein. Such a method can comprise attaching a tip to a handpiece, wherein the tip comprises a perforated bottom surface and a needle array positioned above the perforated bottom surface when the array is in a retracted configuration and operable to pass through the perforated bottom surface when the array is in an extended configuration. The handpiece comprises an actuator operable to move the needle array between the retracted and extended configurations. The method can further comprises placing the perforated bottom surface of the tip in contact with or adjacent to a region of interest (ROI) on the skin and initiating the actuator to move the needle array from the retracted configuration to the extended configuration, thereby penetrating the skin with the needle array. Triggering can be carried out automatically and / or manually. Cooling may also be used in some embodiments.

The invention belongs to the technical field of medical instruments, and particularly relates to a spinal epidural ventral side double-wing-shaped stimulation electrode and motion function reconstruction system, the spinal epidural ventral side double-wing-shaped stimulation electrode and motion function reconstruction system comprises two wing panels, each wing panel comprises a flexible substrate, the flexible substrate is provided with two bifurcated preset-curvature double-wing structures; the electrode contact array is integrated on the flexible polar plate through a bonding pad; according to the double-wing-shaped flexible substrate, through a double-wing structure with a preset curvature, after being unfolded under the driving of a nickel-titanium alloy framework, the double-wing-shaped flexible substrate accurately covers a spinal cord ventral side and double-side anterior angle motor neuron pool, and the problem that a traditional single-piece / rod-shaped electrode can only cover a back side sensing area and cannot cover a back side sensing area is solved. The ventral motor neuron group cannot be directly activated; a stimulation target spot is transferred to a ventral functional core area from a dorsal non-target area for the first time, and the anatomical suitability bottleneck of motor function reconstruction is solved.

To provide a system for transmitting blood pressure reduction electrical stimulation to the heart of a patient capable of determining a desirable AV delay.SOLUTION: The atrium is paced and the ventricle is paced with a given (arbitrary) delay to obtain a desired blood pressure change. Then, the atrium is sensed, the ventricle is paced, the blood pressure change is observed, and the resulting blood pressure change is compared with the paced-atrium-paced-ventricle desired blood pressure change. In the case where the blood pressure changes are not substantially equal, the timing of the sensed-atrium-paced-ventricle stimulation is adjusted on the basis of the comparison. The new modified resulting blood pressure change is observed, and the modified blood pressure change is compared with the paced-atrium-paced-ventricle desired blood pressure change. Adjustment and observation may be repeated until the timing of the sensed-atrium-paced-ventricle stimulation achieves the same blood pressure change as the desired blood pressure change of the paced-atrium-paced-ventricle stimulation.SELECTED DRAWING: Figure 9

The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.

An example of a system for delivering neurostimulation may include a programming control circuit and a user interface. The programming control circuit may be configured to generate stimulation parameters controlling delivery of the neurostimulation according to a pulse sequence. The pulse sequence may include a series of neurostimulation pulses and be defined by sequence parameters and one or more modulation functions each modulating an adjustable parameter selected from the sequence parameters. The user interface may be configured to set the pulse sequence to a tonic pulse sequence by determining an initial value for each adjustable parameter and set the pulse sequence to a modulated pulse sequence by selecting one or more adjustable parameters, determining a modulation function for each selected adjustable parameter, and applying the determined modulation function to that selected adjustable parameter to modulate the tonic pulse sequence.

The invention discloses a patient improvement effect analysis method for controlling spinal cord electrical stimulation through an implantable brain-computer interface, and relates to the technical field of medical rehabilitation, and the method comprises the steps: multi-dimensional collaborative data collection: implanting electrodes in a target brain region and below a spinal cord injury segment, installing a detection element at an exoskeleton key part, and carrying out multi-dimensional collaborative data collection; a sensor is attached to a lower limb preset muscle group, electroencephalogram signals, SCS stimulation parameters, EXS motion data and neuromuscular response data are synchronously collected, and time correlation marks are embedded; according to the method, the reliability of motion intention decoding is remarkably improved by adopting a mode of combining multi-source signal preprocessing and a multi-mode intention recognition model, and in the signal preprocessing stage, the self-adaptive filtering algorithm combining Kalman filtering and wavelet threshold denoising is applied, so that the motion intention decoding efficiency is improved. SCS electrical stimulation interference, EXS motor noise and physiological noise in the electroencephalogram signals are effectively removed.

The invention relates to a three-dimensional spiral high-density neural electrode and a preparation method and application thereof. The three-dimensional spiral high-density neural electrode comprises a probe structure and a plurality of electrode sites. The probe structure is formed by curling a planar flexible electrode precursor, and at least one end of the probe structure is provided with a spiral outer surface of a three-dimensional spiral line structure. Electrode sites are distributed along a spiral path, have a size of 5-1000 [mu] m, and are used for contacting biological tissues. On the planar flexible electrode precursor, electrode sites are arranged on one or more straight lines forming an inclined angle alpha with the axial direction of the probe, and the spatial distribution is matched with the edge. Compared with the prior art, the method has the advantages that the constraint of a traditional wiring mode is broken through, the integration of high-density three-dimensional channels is realized under a micro size, and a new generation of solution is provided for a high-precision brain-computer interface, deep brain stimulation and a three-dimensional electroencephalogram.

Provided is a medical apparatus for a patient comprising an external system and an implantable system. The external system can be configured to transmit one or more transmission signals, each transmission signal comprising at least power or data. The implantable system can be configured to receive the one or more transmission signals from the external system. The external system comprises a first external device comprising at least one external antenna configured to transmit a first transmission signal to the implantable system. The implantable system comprises a first implantable device comprising at least one implantable antenna configured to receive the first transmission signal from the first external device. At least one of the external antenna or implantable antenna comprises an antenna assembly comprising: at least one transmitting / receiving antenna; and at least one shielding element positioned between the at least one transmitting / receiving antenna and an interfering component.

The invention discloses a mouse spinal cord flexible electrode and a stimulation parameter optimization method, and relates to the technical field of parameter optimization. The mouse spinal cord flexible electrode comprises a soluble insertion layer, a gradient substrate layer, spinal cord anastomosis ribs, a conductive snakelike net, a hemispherical touch dot matrix, a microfluidic layer, an optical waveguide layer and a top packaging layer; the soluble insertion layer is photo-crosslinked PEG-DMA with the thickness of 5-25 m, the Young modulus is kept within the range of 0.8-1.5 GPa before implantation, and the soluble insertion layer is hydrolyzed in cerebrospinal fluid within 0.5-3 hours after implantation and completely falls off; the spinal cord anastomosis rib comprises an expandable S-shaped folding structure arranged on the upper surface of the gradient substrate layer, the distance between every two adjacent ribs ranges from 80 m to 200 m, the height of the folded state is not larger than 15 m, the height of the unfolded state ranges from 15 m to 40 m, and the spinal cord anastomosis rib is used for forming a cerebro-spinalfluid bypass groove extending in the longitudinal direction of the spinal cord on the surface of the dura mater. According to the invention, the positioning precision, safety and long-term efficiency of mouse spinal cord electrical stimulation can be effectively improved.

Elongate medical devices with an expandable structure including elongated splines and a distal hub. An elongate medical device includes a handle including a control mechanism, a catheter shaft, an expandable structure including elongated splines and a distal hub, wherein each of the elongated splines includes a shape memory material and an interactive element, wherein each of the elongated splines includes a respective spline proximal end and a spline distal end, wherein each of the spline proximal ends is connected to the catheter shaft distal end, and wherein each of the spline distal ends is connected to the distal hub, and a deflection control member connected to the distal hub, wherein the control mechanism is drivingly coupled to the distal hub via the deflection control member and operable to selectively vary a position of the distal hub relative to the catheter shaft distal end to selectively vary an amount of expansion of the expandable structure, wherein a shape of the expandable structure is produced via a combination of the shape memory material and the position of the distal hub relative to the catheter distal end.

The invention provides a brain deep electrical stimulation electrode parameter determination method and related equipment, and the method comprises the steps: building a head simulation model which comprises conductivity distribution; determining one or more target stimulation target spots and one or more non-target inhibition areas on the head simulation model; based on one or more target stimulation target spots and one or more non-target inhibition areas, multiple groups of electrode configuration schemes are determined through an electrode positioning method, each group of electrode configuration scheme is configured on the head simulation model, and multiple groups of stimulation simulation models are obtained; performing finite element solution based on the anatomical structure and the conductivity distribution of each group of stimulation simulation models, and optimizing the electric field intensity of one or more target stimulation target spots and the electric field intensity of one or more non-target suppression regions to obtain a plurality of electrode parameters; and determining a target electrode parameter in the plurality of electrode parameters, and taking an electrode configuration scheme corresponding to the target electrode parameter as a target electrode configuration scheme.

The invention is applicable to the technical field of medical instruments, and provides a subskull epidural micro-invasive flexible brain-computer interface electrode, which comprises a plurality of electrode branches, each electrode branch comprises a linear flexible main body, and the flexible main body comprises a micro power supply circuit and a signal circuit which are solidified. A plurality of electrode units are arranged on the micro power supply circuit and the signal circuit at intervals, and the electrode units are electrically connected with the micro power supply circuit and the signal circuit. The brain-computer interface electrode is in a flexible line type, can be implanted into the middle artery of the meninx, does not need craniotomy, is a micro-invasive brain-computer interface, has data monitoring accuracy close to that of an invasive brain-computer interface, does not need to worry about inflammatory response, immunostimulation, biocompatibility, brain tissue damage and other adverse factors after long-term implantation, and is suitable for popularization and application. And the thrombogenic risk of a vein stent brain-computer interface does not exist.

The invention discloses a pelvic floor muscle repairing instrument, a pelvic floor muscle training indication method, pelvic floor muscle training indication equipment and a medium, and the pelvic floor muscle repairing instrument comprises a main body part which is used for being inserted into or placed in a part corresponding to pelvic floor muscle; the first electrode and the second electrode are arranged on the main body part and are used for electrically stimulating pelvic floor muscles and detecting pelvic floor muscle surface electromyogram signals after the pelvic floor muscles are electrically stimulated; the third electrode is attached to the peripheral muscle of the pelvic floor muscle during use and is used for detecting an electromyographic signal of the peripheral muscle of the pelvic floor muscle; the posture detection unit is arranged on the trunk part and is used for detecting a posture time sequence signal after the action of the trunk part is changed; the controller is electrically connected with the first electrode and the second electrode and is used for performing feature extraction on the three signals in the same time sequence, generating a fusion feature vector, determining a pelvic floor muscle training evaluation result and generating a training feedback instruction according to the pelvic floor muscle training evaluation result; the training feedback instruction is used for instructing the user to train.

A skin treatment device is disclosed. A skin treatment device with a replaceable tip , according to an embodiment of the present invention, comprises: a body including a shaft for advancing and retreating needles and a driving motor for driving the shaft; a needle tip assembly and a monopolar tip that are selectively coupled to the body; and a tip fixing ring capable of fixing the needle tip assembly or the monopolar tip to the body, wherein the needle tip assembly, when coupled to the body, applies bipolar RF energy and monopolar RF energy to the skin, and the monopolar tip, when coupled to the body, is provided with an electrode that applies monopolar RF energy to a lower surface thereof in contact with the skin.

The embodiments of the present invention relate to the technical field of medical instruments, and disclosed is an electrode array for transmitting a tumor treatment field. The electrode array comprises an implantation main body, and the implantation main body comprises a driving assembly and an electrically insulated electrode support. A plurality of electrodes are arranged on the electrode support, the electrode support is provided with a space structure to be filled with or coat in-vivo target tissues, and the plurality of electrodes are spatially arranged to obtain a three-dimensional electric field. The electrode support is connected to a distal end of the driving assembly, and the driving assembly is configured to drive the electrode support to change the space structure and / or pose so as to change the electric field distribution around the in-vivo target tissues. Due to such arrangement, by changing the space structure and / or pose of the electrode support, a physical distance between sub-electrodes on the electrode support can be reduced, or a physical distance between one electrode and other electrodes can be reduced, and therefore the power required by a system is reduced. Further disclosed is a tumor treatment field-based medical device.

Apparatuses, systems, and methods for prosthetic valves having sensor systems are disclosed. Examples of prosthetic valves include replacement heart valves for replacing the function of a native heart valve, such as a mitral or tricuspid valve. In various embodiments, replacement heart valves are provided with sensors or markers for assisting with proper placement and / or securement in the body. A replacement heart valve may include anchors for securing the replacement heart valve to native leaflets, wherein sensors and / or markers provide feedback to the physician for confirming proper placement of the anchors during the implantation procedure. Sensors may also be used to assess the function of the prosthetic valve after deployment. Sensors may also be used to monitor blood pressure, temperature, oxygen, insulin, cholesterol, and / or glucose to assess overall patient health.

The invention discloses a magnetic resonance compatible implantable electrode wire with a shunt head end structure and medical equipment. An electrode head section comprises a spiral electrode electrically connected with an inner wire body and a ring electrode electrically connected with an outer wire body; the spiral electrode and the ring electrode transmit an electric signal sent by the implanted medical device to a targeted treatment part to be electrically stimulated; the spiral electrode comprises a spiral structure; the spiral structure is a multi-turn equidistant spiral structure, and under the action of a high-frequency energy field, the spiral structure can serve as a series inductor to generate large impedance so as to reduce induction current flowing to the spiral electrode and human tissue, and therefore electrode heating is reduced. The structure of the electrode tip section is improved, and the problems that electromagnetic field energy is coupled, eddy current and induction current are formed, induction heating is generated, and even wrong electric pulse signals are transmitted to a human body on the implantable medical device, so that adverse effects are generated on the safety of a patient are effectively solved.

The invention discloses an acupuncture intervention method after a pancreatic cancer operation, and aims to solve the problem that autonomic nerve regulation based on heart rate variability in an acupuncture stimulation closed loop is difficult to objectize and safely optimize. Heart rate variability time-frequency and time-domain features and respiratory coherence are extracted based on synchronous compression wavelets, a reliability score is generated, short-time heart rate variability and uncertainty are predicted through a neural state space model, a hierarchical control barrier function is generated through a context gating network, a safe MPC is constructed, and real-time quadratic programming solution is carried out. The heart rate variability enters the target domain and the stimulation parameter change rate and the energy consumption are reduced under the condition that safety constraints such as current, pulse width, charge quantity and impedance are met by combining safety verification and self-adaptive updating, and the reliability and the robustness of closed-loop control are improved.

The invention discloses a visual prosthesis control method and system and a storage medium, and relates to the field of medical instruments, and the method comprises the steps: extracting at least one initial target image based on a target object selection result fed back by a user, carrying out the region-of-interest extraction of the initial target image, and obtaining a target object contour image, grouping each contour pixel point based on the brightness values of the contour pixel points in the target object contour map to obtain a plurality of data groups and a stimulation sequence thereof, mapping a stimulation current matrix of each data group based on the stimulation current value and the space coordinate of each contour pixel point, and obtaining a stimulation current matrix of each data group based on the stimulation sequence; and controlling the release of the stimulation current in the electrode array based on each stimulation current matrix in sequence. Redundant information is reduced based on user feedback and region-of-interest extraction, the stimulation sequence based on the average brightness value of each data set is configured, the stimulation current is controlled to be released in the electrode array based on each stimulation current matrix in sequence, and the perception quality of the brain to the target object is improved.

A method for assessing a physiological status of a patient is described herein. The method includes placing at least one pressure sensor in an anterior mediastinal space of the patient. Pressure signal data received from the at least one pressure sensor is amplified and filtered to separate the pressure signal data into different frequency bands. A set of pressure curves is generated based on the separated pressure signals in different frequency bands, and a physiological status of the patient is assessed based at least in part on the set of pressure curves.

Multistranded conductors adapted to in vivo environments and methods of making same are disclosed, wherein specific configurations, sequences and directions of wire wraps provide implantable multistranded coils with increased cycle life in in vivo environments as well as desirable electrical performance characteristics.

A system for delivering a lead an implantable diagnostic / treatment device includes a needle defining a needle lumen and including a biased portion. The biased portion is configured to bias at least a distal end portion of the needle toward a posterior sternal wall when disposed in a body of a patient. The system includes a stylet removably coupled to the needle that is configured to selectively straighten the biased portion of the needle for insertion into the body of the patient. The system includes a guidewire configured to extend through the needle lumen and into the substernal space. The system includes a sheath configured to be advanced over the guidewire to dispose a distal end of the sheath in the substernal space. The sheath defines a sheath lumen allowing the lead to be advanced therethrough to deliver the lead to a substernal space in the body of the patient.

A system for reducing undesired treatments provided to a heart of a patient. The system includes a first sensor configured to measure at least a first characteristic of the heart of a patient and a second sensor configured to measure at least a second characteristic of the heart different from the first characteristic. An implantable cardioverter defibrillator (ICD) configured to be implanted in the patient is in communication with the first sensor and the second sensor. The ICD includes a generator configured to generate treatment energy and a lead configured to deliver the treatment energy. The generator configured to determine a cardiac status based on data from each of the first sensor and the second sensor, determine, based on the cardiac status, if a health event is occurring, and responsive to determining that the health event is an adverse health event, operate the generator to generate the treatment energy.

The invention provides an electrode wire conveying system convenient for cutting and removing a sheathing canal, which belongs to the technical field of cardiac pacemaker implantation, and comprises a conveying carrier with a shell and a movable sheathing canal seat, a cutting assembly arranged in the shell in a manner of moving up and down, and a driving handle movably arranged on the shell and lower than the sheathing canal seat, a rotatable enclasping piece is arranged in the sheathing canal seat, a plough-shaped cutting edge facing the sheathing canal seat is arranged on the cutting assembly, the driving handle is in transmission connection with the enclasping piece and the cutting assembly, and when the driving handle moves, the enclasping piece can be driven to enable the sheathing canal to abut against the inner wall of the through hole in the radial direction, so that the sheathing canal seat can drive the sheathing canal to move synchronously. The sheath tube base can be driven by the holding part to move towards the cutting edge, the cutting edge is synchronously driven to be higher than the lower edge of the through hole along the wall thickness of at least one sheath tube and lower than an electrode wire in the sheath tube, the sheath tube base can be driven by the holding part to move towards the cutting edge, the cutting edge is cut into the end of the sheath tube to achieve cutting and removing of the sheath tube, one-hand operation can be achieved, and operation is easy, stable, small in difficulty and low in risk.

The invention relates to deep brain stimulation equipment capable of realizing an explosive stimulation mode, which comprises a deep brain stimulation unit and a deep brain stimulation electrode which are connected through an in-vivo lead. Wherein the deep brain stimulation unit is configured to enable a deep brain stimulation electrode to perform deep brain stimulation nerve regulation and control on a target spot in an explosive stimulation mode with adjustable stimulation parameters. Wherein one or more of group frequency, intra-group frequency and sine wave quantity in a single stimulation period can be adaptively adjusted by the deep brain stimulation unit according to different electrophysiological characteristics of a target point.

The invention discloses a neural microelectrode for electrical stimulation combined with drug release and a preparation method thereof.The neural microelectrode comprises a first flexible substrate layer, a drug-loaded slow-release layer, a second flexible substrate layer, a conductive layer and an insulating covering layer, and the drug-loaded slow-release layer contains chitosan microspheres embedded with drugs; the medicament comprises nerve growth factors and / or anti-inflammatory drugs, a plurality of drug release holes are distributed in the insulating covering layer, an electrode contact is arranged at one end of the conducting layer, a lead connector is electrically arranged at the other end of the conducting layer, and openings for exposing the electrode contact and the lead connector are correspondingly formed in the two ends of the insulating covering layer respectively. According to the neural microelectrode provided by the invention, the drug-loaded slow-release layer is integrated in the neural microelectrode, so that a space for storing a drug does not need to be additionally processed on the membrane layer, and the drug does not need to be additionally loaded, so that the production and processing are relatively convenient and rapid; after the neural microelectrode is implanted into a corresponding tissue in a body, the drug-loaded sustained-release layer can be gradually degraded to slowly release a medicament for repairing nervous tissues or avoiding rejection reaction in a long-acting manner.

An active implantable medical device (AIMD) is described. The AIMD has a rechargeable electrical energy power source connected to a PCB assembly for powering the medical device. The AIMD can sense biological signals from a patient, or it can have at least two electrodes that provide stimulation therapy to the patient. An inductive charging coil housed inside an elongate device enclosure is connected to the power source. The inductive charging coil has winds of an electrically conductive wire or tape that wrap around the PCB. The winds of the inductive charging coil have an upper wind portion residing above the PCB and a lower wind portion below the PCB. Opposed curved ends of the inductive charging coil winds are continuous with the upper and lower wind portions. This structure provides the inductive charging coil with a length aligned along a longitudinal axis of the PCB. In that manner, the inductive charging coil occupies a space otherwise not used in an elongate cylindrical enclosure for an AIMD.

The invention relates to a conical fixation helix and a capsule (e.g., a leadless pacing, sensing and / or communicating device) that comprises the conical fixation helix for fixing the pacing device at a patient's tissue. The conical shape of the fixation helix provides better attachment of the pacing device to the patient's tissue and compression of the patient's tissue towards a tip electrode of the capsule.