879results about "Internal electrodes" patented technology

The invention belongs to the technical field of medical instruments, and particularly relates to a spinal epidural ventral side double-wing-shaped stimulation electrode and motion function reconstruction system, the spinal epidural ventral side double-wing-shaped stimulation electrode and motion function reconstruction system comprises two wing panels, each wing panel comprises a flexible substrate, the flexible substrate is provided with two bifurcated preset-curvature double-wing structures; the electrode contact array is integrated on the flexible polar plate through a bonding pad; according to the double-wing-shaped flexible substrate, through a double-wing structure with a preset curvature, after being unfolded under the driving of a nickel-titanium alloy framework, the double-wing-shaped flexible substrate accurately covers a spinal cord ventral side and double-side anterior angle motor neuron pool, and the problem that a traditional single-piece / rod-shaped electrode can only cover a back side sensing area and cannot cover a back side sensing area is solved. The ventral motor neuron group cannot be directly activated; a stimulation target spot is transferred to a ventral functional core area from a dorsal non-target area for the first time, and the anatomical suitability bottleneck of motor function reconstruction is solved.

The invention discloses a patient improvement effect analysis method for controlling spinal cord electrical stimulation through an implantable brain-computer interface, and relates to the technical field of medical rehabilitation, and the method comprises the steps: multi-dimensional collaborative data collection: implanting electrodes in a target brain region and below a spinal cord injury segment, installing a detection element at an exoskeleton key part, and carrying out multi-dimensional collaborative data collection; a sensor is attached to a lower limb preset muscle group, electroencephalogram signals, SCS stimulation parameters, EXS motion data and neuromuscular response data are synchronously collected, and time correlation marks are embedded; according to the method, the reliability of motion intention decoding is remarkably improved by adopting a mode of combining multi-source signal preprocessing and a multi-mode intention recognition model, and in the signal preprocessing stage, the self-adaptive filtering algorithm combining Kalman filtering and wavelet threshold denoising is applied, so that the motion intention decoding efficiency is improved. SCS electrical stimulation interference, EXS motor noise and physiological noise in the electroencephalogram signals are effectively removed.

The invention relates to a three-dimensional spiral high-density neural electrode and a preparation method and application thereof. The three-dimensional spiral high-density neural electrode comprises a probe structure and a plurality of electrode sites. The probe structure is formed by curling a planar flexible electrode precursor, and at least one end of the probe structure is provided with a spiral outer surface of a three-dimensional spiral line structure. Electrode sites are distributed along a spiral path, have a size of 5-1000 [mu] m, and are used for contacting biological tissues. On the planar flexible electrode precursor, electrode sites are arranged on one or more straight lines forming an inclined angle alpha with the axial direction of the probe, and the spatial distribution is matched with the edge. Compared with the prior art, the method has the advantages that the constraint of a traditional wiring mode is broken through, the integration of high-density three-dimensional channels is realized under a micro size, and a new generation of solution is provided for a high-precision brain-computer interface, deep brain stimulation and a three-dimensional electroencephalogram.

The invention discloses a mouse spinal cord flexible electrode and a stimulation parameter optimization method, and relates to the technical field of parameter optimization. The mouse spinal cord flexible electrode comprises a soluble insertion layer, a gradient substrate layer, spinal cord anastomosis ribs, a conductive snakelike net, a hemispherical touch dot matrix, a microfluidic layer, an optical waveguide layer and a top packaging layer; the soluble insertion layer is photo-crosslinked PEG-DMA with the thickness of 5-25 m, the Young modulus is kept within the range of 0.8-1.5 GPa before implantation, and the soluble insertion layer is hydrolyzed in cerebrospinal fluid within 0.5-3 hours after implantation and completely falls off; the spinal cord anastomosis rib comprises an expandable S-shaped folding structure arranged on the upper surface of the gradient substrate layer, the distance between every two adjacent ribs ranges from 80 m to 200 m, the height of the folded state is not larger than 15 m, the height of the unfolded state ranges from 15 m to 40 m, and the spinal cord anastomosis rib is used for forming a cerebro-spinalfluid bypass groove extending in the longitudinal direction of the spinal cord on the surface of the dura mater. According to the invention, the positioning precision, safety and long-term efficiency of mouse spinal cord electrical stimulation can be effectively improved.

Elongate medical devices with an expandable structure including elongated splines and a distal hub. An elongate medical device includes a handle including a control mechanism, a catheter shaft, an expandable structure including elongated splines and a distal hub, wherein each of the elongated splines includes a shape memory material and an interactive element, wherein each of the elongated splines includes a respective spline proximal end and a spline distal end, wherein each of the spline proximal ends is connected to the catheter shaft distal end, and wherein each of the spline distal ends is connected to the distal hub, and a deflection control member connected to the distal hub, wherein the control mechanism is drivingly coupled to the distal hub via the deflection control member and operable to selectively vary a position of the distal hub relative to the catheter shaft distal end to selectively vary an amount of expansion of the expandable structure, wherein a shape of the expandable structure is produced via a combination of the shape memory material and the position of the distal hub relative to the catheter distal end.

The invention provides a brain deep electrical stimulation electrode parameter determination method and related equipment, and the method comprises the steps: building a head simulation model which comprises conductivity distribution; determining one or more target stimulation target spots and one or more non-target inhibition areas on the head simulation model; based on one or more target stimulation target spots and one or more non-target inhibition areas, multiple groups of electrode configuration schemes are determined through an electrode positioning method, each group of electrode configuration scheme is configured on the head simulation model, and multiple groups of stimulation simulation models are obtained; performing finite element solution based on the anatomical structure and the conductivity distribution of each group of stimulation simulation models, and optimizing the electric field intensity of one or more target stimulation target spots and the electric field intensity of one or more non-target suppression regions to obtain a plurality of electrode parameters; and determining a target electrode parameter in the plurality of electrode parameters, and taking an electrode configuration scheme corresponding to the target electrode parameter as a target electrode configuration scheme.

The invention is applicable to the technical field of medical instruments, and provides a subskull epidural micro-invasive flexible brain-computer interface electrode, which comprises a plurality of electrode branches, each electrode branch comprises a linear flexible main body, and the flexible main body comprises a micro power supply circuit and a signal circuit which are solidified. A plurality of electrode units are arranged on the micro power supply circuit and the signal circuit at intervals, and the electrode units are electrically connected with the micro power supply circuit and the signal circuit. The brain-computer interface electrode is in a flexible line type, can be implanted into the middle artery of the meninx, does not need craniotomy, is a micro-invasive brain-computer interface, has data monitoring accuracy close to that of an invasive brain-computer interface, does not need to worry about inflammatory response, immunostimulation, biocompatibility, brain tissue damage and other adverse factors after long-term implantation, and is suitable for popularization and application. And the thrombogenic risk of a vein stent brain-computer interface does not exist.

The invention discloses a pelvic floor muscle repairing instrument, a pelvic floor muscle training indication method, pelvic floor muscle training indication equipment and a medium, and the pelvic floor muscle repairing instrument comprises a main body part which is used for being inserted into or placed in a part corresponding to pelvic floor muscle; the first electrode and the second electrode are arranged on the main body part and are used for electrically stimulating pelvic floor muscles and detecting pelvic floor muscle surface electromyogram signals after the pelvic floor muscles are electrically stimulated; the third electrode is attached to the peripheral muscle of the pelvic floor muscle during use and is used for detecting an electromyographic signal of the peripheral muscle of the pelvic floor muscle; the posture detection unit is arranged on the trunk part and is used for detecting a posture time sequence signal after the action of the trunk part is changed; the controller is electrically connected with the first electrode and the second electrode and is used for performing feature extraction on the three signals in the same time sequence, generating a fusion feature vector, determining a pelvic floor muscle training evaluation result and generating a training feedback instruction according to the pelvic floor muscle training evaluation result; the training feedback instruction is used for instructing the user to train.

The invention discloses an acupuncture intervention method after a pancreatic cancer operation, and aims to solve the problem that autonomic nerve regulation based on heart rate variability in an acupuncture stimulation closed loop is difficult to objectize and safely optimize. Heart rate variability time-frequency and time-domain features and respiratory coherence are extracted based on synchronous compression wavelets, a reliability score is generated, short-time heart rate variability and uncertainty are predicted through a neural state space model, a hierarchical control barrier function is generated through a context gating network, a safe MPC is constructed, and real-time quadratic programming solution is carried out. The heart rate variability enters the target domain and the stimulation parameter change rate and the energy consumption are reduced under the condition that safety constraints such as current, pulse width, charge quantity and impedance are met by combining safety verification and self-adaptive updating, and the reliability and the robustness of closed-loop control are improved.

The invention discloses a visual prosthesis control method and system and a storage medium, and relates to the field of medical instruments, and the method comprises the steps: extracting at least one initial target image based on a target object selection result fed back by a user, carrying out the region-of-interest extraction of the initial target image, and obtaining a target object contour image, grouping each contour pixel point based on the brightness values of the contour pixel points in the target object contour map to obtain a plurality of data groups and a stimulation sequence thereof, mapping a stimulation current matrix of each data group based on the stimulation current value and the space coordinate of each contour pixel point, and obtaining a stimulation current matrix of each data group based on the stimulation sequence; and controlling the release of the stimulation current in the electrode array based on each stimulation current matrix in sequence. Redundant information is reduced based on user feedback and region-of-interest extraction, the stimulation sequence based on the average brightness value of each data set is configured, the stimulation current is controlled to be released in the electrode array based on each stimulation current matrix in sequence, and the perception quality of the brain to the target object is improved.

A method for assessing a physiological status of a patient is described herein. The method includes placing at least one pressure sensor in an anterior mediastinal space of the patient. Pressure signal data received from the at least one pressure sensor is amplified and filtered to separate the pressure signal data into different frequency bands. A set of pressure curves is generated based on the separated pressure signals in different frequency bands, and a physiological status of the patient is assessed based at least in part on the set of pressure curves.

Multistranded conductors adapted to in vivo environments and methods of making same are disclosed, wherein specific configurations, sequences and directions of wire wraps provide implantable multistranded coils with increased cycle life in in vivo environments as well as desirable electrical performance characteristics.

A system for delivering a lead an implantable diagnostic / treatment device includes a needle defining a needle lumen and including a biased portion. The biased portion is configured to bias at least a distal end portion of the needle toward a posterior sternal wall when disposed in a body of a patient. The system includes a stylet removably coupled to the needle that is configured to selectively straighten the biased portion of the needle for insertion into the body of the patient. The system includes a guidewire configured to extend through the needle lumen and into the substernal space. The system includes a sheath configured to be advanced over the guidewire to dispose a distal end of the sheath in the substernal space. The sheath defines a sheath lumen allowing the lead to be advanced therethrough to deliver the lead to a substernal space in the body of the patient.

The invention discloses a neural microelectrode for electrical stimulation combined with drug release and a preparation method thereof.The neural microelectrode comprises a first flexible substrate layer, a drug-loaded slow-release layer, a second flexible substrate layer, a conductive layer and an insulating covering layer, and the drug-loaded slow-release layer contains chitosan microspheres embedded with drugs; the medicament comprises nerve growth factors and / or anti-inflammatory drugs, a plurality of drug release holes are distributed in the insulating covering layer, an electrode contact is arranged at one end of the conducting layer, a lead connector is electrically arranged at the other end of the conducting layer, and openings for exposing the electrode contact and the lead connector are correspondingly formed in the two ends of the insulating covering layer respectively. According to the neural microelectrode provided by the invention, the drug-loaded slow-release layer is integrated in the neural microelectrode, so that a space for storing a drug does not need to be additionally processed on the membrane layer, and the drug does not need to be additionally loaded, so that the production and processing are relatively convenient and rapid; after the neural microelectrode is implanted into a corresponding tissue in a body, the drug-loaded sustained-release layer can be gradually degraded to slowly release a medicament for repairing nervous tissues or avoiding rejection reaction in a long-acting manner.

The utility model relates to the technical field of cardiovascular intervention. The utility model provides an electrode wire guiding sheath. The electrode wire guiding sheath comprises a handle provided with a bending adjusting piece and a sheath tube body. The near end of the sheathing canal body is connected with the handle, a bending adjusting steel wire channel extending from the near end to the far end is arranged in the canal wall of the sheathing canal body, the bending adjusting steel wire is arranged in the bending adjusting steel wire channel, and the bending adjusting steel wire is connected with a bending adjusting piece of the handle at the near end of the sheathing canal body so that bending of the bending adjusting steel wire can be adjusted through the bending adjusting piece. A tearing line groove extending from the near end to the far end is further formed in the pipe wall of the sheathing pipe body, and the tearing line groove and the bending adjusting steel wire channel do not coincide. According to the guide sheath, the electrode wire can be shaped through the bending adjusting piece and the bending adjusting steel wire, meanwhile, the tearing line groove is formed in the tube wall of the sheath tube body, the tearing line groove and the bending adjusting steel wire do not interfere with each other, and the sheath tube body can be conveniently withdrawn after the electrode wire is implanted into the heart.

A modular lead connector for a medical device is described. The modular lead connector comprises an alumina ring having opposed first and second faces provided with respective first and second metallizations. First and second gold washers are contacted to the respective first and second metallizations, and the ceramic ring supporting the first and second gold washers is positioned between first and second titanium contact rings. Then, with the ceramic ring and the titanium contact rings being in axial alignment, they are hermetically connected to each other at respective first and second titanium / gold / alumina diffusion bonds. A lead connector assembly comprising at least two modular lead connectors in axial alignment and welded together is also described. An open sleeve is connected to a proximal-most one of the axially aligned modular lead connectors, and a terminal plate is welded to a distal-most one of the axially aligned modular lead connectors.

The invention relates to the technical field of flexible bioelectronics and biomedical sensors, in particular to a biocompatible flexible carbon-based physiological electrode prepared through coaxial spinning and application of the biocompatible flexible carbon-based physiological electrode. The conductive core is formed by crosslinking graphene oxide, carbon nanotubes and the like; the buffer layer contains polyurethane and the like, and shape memory microspheres and antibacterial nano-silver are added; a biological interface layer contains chitosan and the like, and PEG-PE is grafted to reduce protein adsorption; the thickness ratio of the three layers is 1: (1.5-2): (0.5-1), and the thickness is 100-300 microns; the electrode has conductive, sensing and antibacterial functions, can load double enzymes for blood glucose monitoring, is strong in interlayer bonding, and is suitable for various biomedical scenes. By innovating the three-layer structure and the material design, high conductivity, high flexibility and excellent biocompatibility are achieved; multi-parameter monitoring and electrical stimulation treatment can be achieved, the anti-bending performance is good, the antibacterial and anticoagulant effects are good, the preparation process is controllable, and the application prospects in the fields of wearable equipment, implantation medical treatment and the like are wide.

The invention discloses a deep brain targeted stimulation method based on a time-frequency interference technology, and relates to the technical field of nerve regulation, and an application system comprises a plurality of pairs of stimulation electrode modules, a data acquisition module, a data preprocessing module, a time-frequency interference stimulation signal generation module, a central control module and a data storage module. According to the method, a multi-azimuth surrounding layout of multiple pairs of stimulation electrodes is combined with a time-frequency interference technology, so that a high-frequency electric field forms constructive interference in a deep brain target area, and meanwhile, a frequency difference is dynamically adjusted based on different organism state requirements; and a closed-loop control system of data acquisition, preprocessing, state evaluation, parameter adjustment and stimulation application is constructed. The problems that a traditional deep brain stimulation technology is low in targeting precision, poor in state guiding efficiency and insufficient in stimulation system stability are solved, the energy focusing degree is improved to 90% or above, the sleep induction time is shortened to 20-30 minutes, and the method can be widely applied to nerve disease treatment and physiological state improvement.

The utility model relates to the technical field of medical instruments, in particular to a pacemaker electrode wire, which comprises a wire conduit, the wire conduit comprises a head part and a tail part which are connected with each other, the head part is provided with an electrode assembly, and the electrode assembly comprises a first electrode and a second electrode which are electrically connected with each other. The first electrode and the second electrode are arranged in a spaced mode in the direction from the head to the tail, and a fixing piece located between the first electrode and the second electrode is arranged on the outer side of the wire conduit. The head of the wire conduit can be sent to the right ventricular apex of the heart of a patient through vein puncture, and the fixing piece is in contact with and fixed to the surface of the endocardium, so that the first electrode is firmly fixed to the right ventricular apex, the electrode wire is kept stable in the heart of the patient, and the electrode wire is prevented from shifting or falling off; and the normal cardiac function of the patient is ensured.

The utility model relates to the technical field of nerve stimulation, and discloses an electrode contact, an implantable electrode and a nerve stimulation system. The electrode contact comprises a plurality of contact surfaces, each contact surface can independently serve as a stimulation source, and at least two contact surfaces in the plurality of contact surfaces face different directions, so that the electrode contact has a plurality of stimulation directions. According to the electrode contact scheme provided by the embodiment of the utility model, more stimulation directions can be provided, and the effectiveness and accuracy of nerve stimulation can be improved.

The utility model discloses an electrode assembly. The electrode assembly comprises: an electrode wire, wherein the electrode wire comprises a guide wire and a stimulation end; the stimulation end is at least partially implanted into a target area, the stimulation end is provided with a plurality of stimulation contacts, and the stimulation contacts are electrically connected with the guide wire; the adjacent stimulation contacts are insulated and separated through an isolation structure, and the stimulation end is provided with at least one drug release channel; the medicine supply assembly comprises a medicine storage cavity and at least one medicine conveying channel, the medicine conveying channel is arranged in the electrode wire, one end of the medicine conveying channel is communicated with the medicine storage cavity, the medicine conveying channel is provided with at least one outer conveying channel, and the outer conveying channel is connected with the medicine release channel. According to the utility model, electric signal stimulation and drug release can be realized synchronously.

A system and method for spinal fusion that can include: a spinal cage body that includes at least one defined graft window cavity; a plurality of electrodes exposed on the surface of the spinal cage body; control circuitry configured to drive the plurality of electrodes in a stimulation mode; wherein there is at least a targeted osteoinduction region and a targeted non-osteoinduction region that are immediately adjacent to the spinal cage body; and wherein the control circuitry includes configuration to excite the plurality of electrodes during the stimulation mode for generation of a current density in the targeted osteoinduction region and targeted non-osteoinduction region according to targeted levels of bone growth.

Embodiments herein relate to a medical device for treating a cancerous tumor, the medical device having a first lead including a first wire and second wire; a second lead can include a third wire and fourth wire; and a first electrode in electrical communication with the first wire, a second electrode in electrical communication with the second wire, a third electrode in electrical communication with the third wire, and a fourth electrode in electrical communication with the fourth wire. The first and third electrodes form a supply electrode pair configured to deliver one or more electric fields to the cancerous tumor. The second and fourth electrodes form a sensing electrode pair configured to measure an impedance of the cancerous tumor independent of an impedance of the first electrode, the first wire, the third electrode, the third wire, and components in electrical communication therewith. Other embodiments are also included herein.

This paper presents a medical device for treating traumatic brain injury and cerebral thrombosis through electroacupuncture. The device includes a 6-DOF (degree of freedom) mechanical arm, a multifunctional tool tip, an MRI helmet suitable for acupuncture, and magnetic resonance imaging (MRI). The acupuncture robot can insert needles and automatically manipulate specific needles by rotating or vibrating them within a specific frequency range, and can enhance the effect by applying electrical stimulation.

The utility model relates to the field of brain electrodes, in particular to an electroneurographic signal acquisition and stimulation unit capable of shortening implantation duration, which comprises an electrode wire, an electroneurographic signal acquisition and stimulation unit and an electroneurographic signal acquisition and stimulation unit, the curing assembly is used for wrapping and restraining the roots of the electrode wires, so that the adjacent electrode wires are kept parallel to each other; the shaping part is made of a material which can be dissolved in the process of implanting the electrode wire into the brain area and is used for being solidified at the connecting part of the solidifying assembly and the electrode wire so as to wrap and restrain the electrode wire; wherein the part, exposed on the outer side of the shaping piece, of the electrode wire is straight, the part, restrained on the inner side of the shaping piece, of the electrode wire is bent, and the electrode wire has the elastic force for restoring to be straight after being released from the inner side of the shaping piece. According to the embodiment of the utility model, on the premise that the length of the electrode wire is not shortened, the length of the shaping piece is shortened, so that the speed of completely dissolving the shaping piece is accelerated, and the total time of implanting the electrode wire is further reduced.

The invention discloses an instrument implantation safety analysis method under regulation and control of a brain-computer interface and spinal nerve, and relates to the technical field of crossing of biomedical engineering and neural engineering. According to the model, a BCI decoding instruction and an actually-collected multi-modal physiological signal are used as input, parameter identification continuous optimization is carried out, the difference between actual spinal cord response and expected response generated by the model is calculated, a predicted value and an actual value of a coupling dynamics model are compared in real time, a risk value is dynamically calculated, once a threshold value is exceeded, risk leading factors are locked immediately, and the risk leading factors are locked immediately. According to the method, a BCI-SCN system is constructed, a high-specificity self-adaptive adjustment mechanism is triggered, it is ensured that the BCI-SCN system always works in a safe interval in a complex and changeable human nerve environment, macroscopically observed abnormal phenomena are accurately traced to specific reasons of a microscopic level, and a decision basis is provided for subsequent accurate regulation and control.

The utility model provides a sheet-shaped electrode and an implantation device, the sheet-shaped electrode comprises an electrode slice, the surface of the electrode slice is provided with an electrode contact, the electrode slice has flexibility, and the electrode slice can be curled and contracted into a cylindrical shape matched with a pushing catheter, or the electrode slice can be unfolded into a sheet shape outside the pushing catheter; and the electrode wire is connected to one end of the electrode plate, the electrode wire is electrically connected with the electrode contact, the electrode wire can be arranged in the pushing catheter or the withdrawing catheter in a penetrating manner, and the electrode wire is used for dragging the electrode plate, so that the electrode plate and the withdrawing catheter are matched with each other and are curled and contracted in the withdrawing catheter. Surgical operations such as laminectomy or laminotomy are not needed in the implanting operation process, the invasive property is small, trauma and operation risks are reduced, and the sheet-shaped electrode plates are not prone to displacement. In addition, the electrode plate can be withdrawn from the body along with the withdrawing catheter, and withdrawing and recycling of the electrode plate are achieved.

A device comprising: an elongated housing extending from a proximal end to a distal end along a longitudinal axis, the elongated housing being configured to be implanted wholly within a chamber of a heart; a first electrode extending distally from the distal end of the elongated housing, the first electrode comprising an elongated body defining a helix; a second electrode disposed on the distal end of the elongated housing, wherein the second electrode is configured to contact wall tissue of the chamber without penetrating the wall tissue; and one or more fixation features disposed on or about the distal end of the elongated housing, each fixation feature of the one or more fixation features defining a textured outer surface configured to interface with the wall tissue of the chamber to inhibit unintended movement of the elongated housing relative the wall tissue.

Provided is a method for treating musculoskeletal atrophy in patients suffering from a neurological or neuromuscular disease or disorder by combining testosterone replacement therapy with neuromuscular electrical stimulation of multiple muscle groups and, optionally, physical activity.