171 results about "Cranial nerves" patented technology

A neurophysiological magnetic stimulation (NMS) method includes obtaining motor thresholds over one or both motor strips adhered to the patient's head or the equivalent anatomic region for treatment of non-brain, nervous system disorders. The method further includes applying magnetic stimulation coils to a therapeutic target region of the patient's brain, brainstem, spinal cord, or peripheral nervous system and applying NMS in increasing amplitudes as tolerated over the course of treatment.

The invention discloses percutaneous nerve field vagus nerve stimulation diagnosis and treatment equipment and a diagnosis and treatment method thereof, and particularly relates to the technical field of neuromedicine, intelligent medical equipment and multi-mode physical therapy. The equipment comprises a neural signal acquisition module, a nerve positioning module, a data processing and analysis module, a treatment execution module and a diagnosis result output module; the system is further provided with a battery power management module, a self-adaptive closed-loop cloud platform and a wearable fixing device, by collecting bioelectricity signals, light absorptivity and temperature data of an ear nerve area, ear target cranial nerve branches are positioned, a dynamic diagnosis map is constructed, and a diagnosis result and personalized treatment parameters are generated. Electric pulse, near-infrared light and local thermal therapy multi-mode collaborative stimulation is adopted for treatment, and parameters are monitored and adjusted in real time through a cloud platform. According to the invention, accurate diagnosis and personalized treatment can be realized, the medical efficiency and the treatment effect are improved, and an effective means is provided for nerve disease diagnosis and treatment and pain relief.

The invention discloses a student high-order thinking evaluation system based on artificial intelligence, and belongs to the technical field of artificial intelligence learning evaluation. In order to solve the problems of insufficient data integration ability and incomplete evaluation of the current learning evaluation system, the invention aims to develop a student high-order thinking evaluation system based on artificial intelligence, and the system combines the latest education, psychology, learning science, cranial neuroscience and information technology theories. And a comprehensive, systematic and digital-intelligent high-order thinking evaluation system is constructed. The system monitors and analyzes the learning process and high-order thinking degree of students in real time through the artificial intelligence technology, and generates personalized feedback and suggestions. Meanwhile, the system integrates multi-source data, covers cognitive and non-cognitive factors of the students, and realizes comprehensive evaluation of abstraction, meta-cognition, criticality, anti-fact-hypothesis and creative thinking of the students. The system provides a brand new scheme for education evaluation, and promotes digital transformation of education evaluation.

The invention provides an application of a human retina organ in preparation of a medicament for treating traumatic optic neuropathy. According to the invention, the induced and differentiated human retina-like organ is applied to the optic nerve injury area, and the eye and brain nerve connection can be functionally reconstructed, so that the damaged visual function is recovered.

The invention provides a surgical process management method and system, and relates to the technical field of surgical process management.The method comprises the steps that DTI, fMRI and 3D-T1WI image data are fused through a non-rigid registration algorithm, a three-dimensional brain network atlas is generated, then an LSTM deep learning model is constructed, a brain surface displacement field monitored in real time in an operation is used as input, and an LSTM deep learning model is constructed; a deep tissue displacement value is used as a label for training to obtain a deep tissue displacement predicted value, and a dynamic relation between brain neural element electrical activity and oxyhemoglobin saturation is analyzed by combining data monitored by high-frequency EEG and near infrared spectrum and utilizing a wavelet time-frequency coherence algorithm to obtain a dynamic influence coefficient; and finally, combining the deep tissue displacement predicted value with the dynamic influence coefficient, calculating a comprehensive evaluation index, and comparing the comprehensive evaluation index with a preset threshold value, so that a surgeon can quickly adjust an operation strategy and timely deal with possible risks.

The invention provides a cognitive function evaluation method based on neurovascular coupling analysis. The method comprises a signal preprocessing step, a signal processing step, a feature extraction step and a coupling coefficient calculation step. A new normal form of cognitive evaluation is constructed from nerve-blood vessel coupling and cross-system cooperation dimensions, and accurate description of a cognitive state is realized through real-time quantification of a dynamic cooperation effect of brain nerve activity (EEG) and blood flow regulation (CBP variability) and establishment of an association relationship between a dynamic cooperation index and cognitive ability (alertness, reaction speed and memory). And a new objective basis is provided for the fields of plateau medicine, intelligent health, neurological and mental disease diagnosis and treatment and the like.

The invention discloses an audio feature extraction method based on a cranial nerve model, and the method comprises the steps: obtaining voice signal data, carrying out the preprocessing of a voice signal, and segmenting the voice signal into N voice segments; extracting acoustic features representing emotional conditions from each voice segment, normalizing the acoustic features, and synthesizing the acoustic features into a multi-channel voice spectrogram; and inputting the multi-channel speech spectrogram into the RBA-FE model, outputting a BDI score, carrying out depression degree prediction classification according to the BDI score, adjusting parameters of each network layer in the RBA-FE model according to the difference between prediction classification and actual classification, and obtaining an optimal RBA-FE model to carry out depression degree detection. According to the method, the cell selectivity in the auditory cortex of the human brain is simulated, the problems of overfitting and non-noise resistance of the LSTM are solved by adopting a self-adaptive activation mechanism, and precise recognition of the depression voice under different noise interferences is realized.

The invention relates to the technical field of electroencephalogram examination, and discloses an electroencephalogram examination device for cranial nerve feedback training, which comprises a support column, a lantern ring, a transverse plate, a vertical frame and a helmet, the supporting column is vertically fixed to the upper portion of the side edge of the balance weight seat, the lantern ring is rotatably arranged on the outer ring of the upper portion of the supporting column in a sleeving mode, the limiting plates close to the lantern ring are fixed to the portions, above and below the lantern ring, of the outer ring of the supporting column, the transverse plate is transversely welded and fixed to the side edge of the lantern ring, and a transverse penetrating opening penetrating vertically is formed in the surface of the transverse plate. The vertical frame is arranged in the penetrating opening of the transverse plate in a sliding mode, the transverse plate can rotate, the position of the vertical frame can be changed at will so that a wearer can use the helmet at different positions conveniently, the lifting rope is connected to the upper portion of the helmet and wound around the fixed pulley in the vertical frame, the balancing weight is connected to the tail end of the fixed pulley, and the weight of the balancing weight is smaller than that of the whole helmet; the helmet can be lifted upwards, so that the burden on the head of a person to be detected when the person wears the helmet is reduced, and long-time detection is easier.

The invention relates to the technical field of electroencephalogram characteristic index calculation, and discloses a chronic pain electroencephalogram index calculation algorithm, which comprises a data preprocessing stage, a multi-layer perceptron architecture design, a model training stage, a model evaluation stage and a multi-scale information fusion stage. The data preprocessing stage further comprises normalization and data division; the architecture design of the multi-layer sensor comprises an input layer, a hidden layer and an output layer; the model training stage comprises a loss function and optimization algorithm, forward propagation, loss calculation, back propagation and parameter updating one-set repeated training; in the model evaluation stage, evaluation needs to be carried out on a test set, and hyper-parameters are adjusted. According to the method, the connection strength or the activity level of different regions of the brain under different threshold values is reflected, the association between the brain nerve activity and the chronic pain can be described more comprehensively by fusing the connection strength or the activity level, the pain related mode hidden in the association can be mined, the limitation of single feature analysis is avoided, and comprehensive evaluation of the chronic pain is facilitated.

The invention relates to a time coherence electrical stimulation regulation and control method based on target region self-adaption. The method comprises the following steps: acquiring image information of a user and constructing a craniocerebral nerve three-dimensional model according to the image information; adding a simulation electrode in the craniocerebral nerve three-dimensional model, and configuring stimulation attributes of the simulation electrode; obtaining position information of a target region, and mapping the target region into the craniocerebral nerve three-dimensional model through a pre-constructed mapping matrix; calculating the volume of the target region according to a preset volume calculation algorithm, obtaining a corresponding electrode layout instruction from a pre-constructed layout mapping library according to the volume of the target region, and configuring the simulation electrode in a corresponding craniocerebral nerve three-dimensional model according to the electrode layout instruction; and configuring a corresponding optimal stimulation parameter through a preset parameter adaptation sub-strategy so as to enable the envelope modulation electric field in the craniocerebral nerve three-dimensional model to be matched with the target region. TI electrical stimulation parameters can be adaptively adjusted, and the problem that existing TI electrical stimulation parameters are difficult to set is solved.

The present invention relates to a helmet-type magnetic stimulation device for providing non-invasive treatment by applying a magnetic field to cranial nerve cells or scalp cells, the helmet-type magnetic stimulation device comprising: a helmet-type case part; a magnetic field generation part for generating a magnetic field in order to apply a magnetic field to the head; and a fixing part installed on one inner side of the case part to fix and support the magnetic field generation part at a predetermined position on the head. Therefore, the present invention includes a magnetic field generation part for generating a magnetic field in order to apply a magnetic field to the head, inside the case part.

The invention discloses a system for analyzing the influence of photostimulation on amygdala function regulation and control, and relates to the field of brain nerve regulation and control, the system comprises a photostimulation module, an intracranial electroencephalogram recording module and an amygdala physiological activity analysis module, the photostimulation module issues intermittent photostimulation to a subject; the intracranial electroencephalogram recording module is used for recording continuous electroencephalogram signal data of the amygdala before and during photostimulation of the subject; the amygdala physiological activity analysis module preprocesses the electroencephalogram signal data, judges the amygdala function change of a specific frequency band according to the neural oscillation energy change rate of the specific frequency band, and forms an optical frequency-amygdala function change database, thereby obtaining the optical stimulation frequency influencing the amygdala function. The invention can overcome the problem that the scalp electroencephalogram is difficult to capture the nerve activity of the amygdala nucleus; in addition, the photostimulation frequency capable of influencing the functions of the amygdala kernel is obtained, and clinical reference is provided for accurately intervening the functions of the amygdala kernel.

The invention relates to a cranial nerve motor function evaluation system and method based on a terminal with a camera. The system comprises a camera used for collecting a high-definition video sequence of facial actions; the model is used for identifying positioning points of the face according to the high-definition video sequence acquired by the camera; the analysis and evaluation module is used for quantitatively evaluating the cranial nerve motor function state according to the change of the positioning points of the face acquired by the model; the analysis and evaluation module performs analysis and evaluation according to the change quantitative indexes of the positioning points of the face; the camera, the model and the analysis and evaluation module are all deployed at the terminal; and the model and the analysis and evaluation module are deployed in an operating system of the terminal. The evaluation system and method are deployed on a common terminal, and are used for collecting a video sequence of a user completing a standard evaluation action, automatically identifying the movement of a positioning point of a face, and outputting a quantitative score according to a medical standard so as to evaluate human face muscle movement and a cranial nerve function state.

The application provides a wireless and battery-free brain nerve stimulator and a preparation method. The brain nerve stimulator can be driven by a mobile phone loudspeaker, and a resonator designed can effectively amplify a piezoelectric signal. The brain nerve stimulator comprises two parts: a base provided with implantable nerve stimulation electrodes and a resonant cavity device connected through magnetic coupling. The design scheme of the brain nerve stimulator provides a general method for inhibiting epilepsy. The brain nerve stimulator can be extended to target brain deep layers or surface areas and peripheral nervous systems. A stimulation mode can be wirelessly transmitted and controlled. It is proved by electroencephalogram recording of free-moving mice that the wireless nerve stimulator can effectively relieve seizure events of the epileptic mice in vivo.

The present invention relates to the field of medical rehabilitation, and specifically discloses an upper limb cranial nerve rehabilitation training system and training method. The upper limb training control system includes: an information acquisition module that collects historical trainee upper limb motion trajectory information and upper limb training parameters based on a multidimensional sensor; a virtual reality and human-computer interaction module that displays a training virtual reality scene based on a trainee's head-mounted display, and controls a robot to drive the trainee's upper limb to perform motion based on the training virtual reality scene and controls the trainee's head-mounted speaker to feed back the robot training information; a trajectory tracking module that obtains the trainee's upper limb training feedback after human-computer interaction in real time, and tracks and follows the upper limb training movement trajectory in real time; a warning analysis module that analyzes the tracking results of the upper limb training movement trajectory and receives the trainee's upper limb training feedback and warnings; and a feedback module that adjusts the trainee's upper limb motion trajectory information based on the upper limb training feedback and updates a three-dimensional trajectory model.

Neurostimulation therapy can be efficiently controlled based on information from an acceleration signal, such as can be obtained from an accelerometer. In an example, the accelerometer can be implanted in a cervical region or submandibular region of a patient. Circuitry can be configured to identify a first series of respiration phase transition events in the acceleration signal and, in response, provide the neurostimulation therapy synchronously with an inspiration phase of a patient's respirator cycle. In an example, m absence of identifying the first series of respiration phase transition events in the acceleration signal, the neurostimulation therapy can be provided asynchronously with the patient's respiratory cycle.

The application discloses a cistema brain-computer interface-minimally invasive whole brain nerve signal acquisition and closed-loop control system based on a cerebrospinal fluid channel and a method thereof. The system comprises a flexible cistema interface array, an ultra-wideband wireless energy and data synchronous transmission module, a nerve signal analysis and decoding module, a self-adaptive closed-loop control module and a system integrated control platform. The flexible cistema interface array is implanted in a cerebrospinal fluid cavity in a minimally invasive manner to acquire multi-brain region nerve signals; and the ultra-wideband transmission module realizes energy supply and high-speed bidirectional communication between an implanted body and an extracorporeal device. The application solves the problems of a large trauma, limited coverage and poor signal quality of an existing invasive interface, has the advantages of minimally invasive, wide area coverage, high signal quality and good integration, and is suitable for diagnosis and treatment of neurological diseases such as epilepsy suppression and post-stroke motor function reconstruction.

The invention relates to a dietary therapy formula for repairing cerebral nerve cells and a preparation method of the dietary therapy formula. Components with homology of medicine and food are selected to be matched with components with specific nutritional values and traditional Chinese medicine components, the mixture A, the mixture B and the traditional Chinese medicine components are obtained through mixing, then the mixture A, the mixture B and the traditional Chinese medicine components are mixed and smashed, and the dietary therapy product capable of repairing the cerebral nerve cells is obtained. The used components are safe and free of side effects, and can be eaten daily according to needs. The product is a non-medicinal product, can reduce the psychological burden of eaters taking medicines for a long time, can expand the crowd, and is beneficial to popularization and application.

To provide a mammalian epilepsy model.SOLUTION: A mammalian epilepsy model is obtained by a method comprising (i) injecting an RNA-interfering shRNA having a specific nucleic acid sequence of a nucleic acid encoding CREB-controlled transcriptional coactivator 1 into three or more different brain or cranial nerve regions of a mammal; or (ii) injecting an RNA-interfering shRNA having a specific nucleic acid sequence of a nucleic acid encoding CREB-controlled transcriptional coactivator 1 into two or more different brain or cranial nerve regions of a mammal and injecting an RNA-interfering shRNA having a specific nucleic acid sequence of a nucleic acid encoding CREB-controlled transcriptional coactivator 1 into one or more different brain or cranial nerve regions of a mammal.SELECTED DRAWING: None

The invention provides a method for judging the connection state of a nerve monitor and human nerves. According to the method, impedance detection is started through a system, a driving source signal is output, a system connection signal is collected for preprocessing, and interference factors are removed. Thirdly, FFT Fourier transform is carried out on the preprocessed signals, amplitudes are recorded, and amplitudes corresponding to different impedances are calculated through a standard resistor; and establishing a corresponding relation model of the impedance values and the calculated amplitudes by using a least square method, and calculating the change rate of the continuous impedance values. And finally, according to the impedance value, the change rate and a preset connection test classification state, utilizing an expert system to judge the connection states of the nerve monitor and the human nerves, including over-low, OK, over-high, disconnection and the like. According to the method, the accuracy of nerve detection and the safety and reliability of instrument use are improved, and the method is suitable for monitoring signals of cranial nerves, spinal nerves or peripheral nerves.

The application discloses an indigo red derivative, a preparation method of the indigo red derivative, and application of the indigo red derivative in preparation of an anti-cerebral ischemia neuroprotective drug or a drug component. The indigo red derivative has good anti-cerebral ischemia neuroprotective activity, can overcome defects of existing active ingredients, such as easy bleeding, difficulty in penetrating a blood-brain barrier, poor oral bioavailability, low selectivity, and high neurobehavioral toxicity, and can be used as a cerebral neuroprotective active ingredient for treatment of ischemic cerebral stroke. According to an animal experiment of cerebral neuroprotective activity screening, it can be seen that after the compound is given preventively, the survival time of acute cerebral ischemia mice can be obviously prolonged, and the compound has good anti-cerebral ischemia neuroprotective effect.

To provide a system for stimulating cranial nerves.SOLUTION: A neuromodulation system for nerve adjustment of cranial nerves can be used to treat sleep or breathing disorders. The system can include a first housing configured to be implanted in a triangular region below a chin cap of a patient. The system can include a first electrode lead coupled to the first housing, and the first electrode lead can include an electrode configured to be disposed at or near a first cranial nerve target in the patient. The system can be provided with a signal generating circuit configured to generate electrical neuromodulation signals for delivery to the first cranial nerve target by using the electrode.SELECTED DRAWING: Figure 9

An organic sol-gel nano-composition containing three solid lipid nano-components loaded with phytochemical active ingredients is proposed. Panax notoginseng saponins are extracted from Vietnamese Panax notoginseng. Rutin is extracted from Styphnolobium japonicum in Thai Binh Province, Vietnam, and Ginkgo biloba is extracted from Ginkgo biloba trees. The composition has shown to have low toxicity and great bioavailability. In particular, the composition is effective against local myocardial ischemias and arrhythmias, improves the blood rheology, platelet circulation and antiaggregation, and thrombosis, lowers the blood lipids to a certain limit, and has good effects against atherosclerosis. The composition has an antioxidant effect of preventing free radical damages, and has an effect of enhancing capillary resistance, strengthening the vessel walls that reduces hypertension risks, which accordingly protects the cerebral nerves, prevents strokes, and is also used to recover after strokes and other hemorrhagic diseases for the enhancement effects and reconstruction of the damaged blood vessels.

The application provides an analgesia system based on brain nerve oscillation regulation, relates to the technical field of pain regulation, and first establishes a brain signal standardization information base of healthy people; for each pain patient, the brain nerve signal index of the pain patient is compared with a standard normal range obtained from the brain signal standardization information base of healthy people to determine abnormal electroencephalogram nerve indexes of each pain patient; then, according to the pain specificity of each pain patient, the correlation between the behavior indexes and the abnormal electroencephalogram nerve indexes of the pain patient is analyzed to determine potential regulation target points; the regulation target points to be intervened and regulation modes are selected from the potential regulation target points; different regulation modes are selected according to actual requirements to regulate the pain of the pain patient; and then, the pain regulation effect is evaluated, so that the effect of relieving pain is achieved, the analgesia system has the characteristics of safety, economy and easy operation, and is expected to be applied to the treatment of clinical pain.

The utility model discloses a cranial nerve patient postoperative rehabilitation chair which comprises a chair frame, a cushion, a backrest, armrest frames, a bidirectional motor, a rotating wheel, a shaft sleeve, a movable rod, movable armrests, a binding belt and a controller, and the armrest frames are arranged on the left side and the right side of the chair frame; the two-way motor is fixedly arranged at the bottom of the chair frame, a rotating wheel is fixedly arranged on a two-way output shaft of the two-way motor, and the shaft sleeve is rotatably arranged on the armrest frame; one end of the movable rod is rotatably connected with the non-circle-center position of the rotating wheel, and the other end of the movable rod penetrates through the shaft sleeve and is hinged with the movable handrail; the movable armrest is positioned above the armrest frame; binding belts are arranged on the movable armrests; and the controller is arranged at the bottom of the chair frame. The rehabilitation chair has the innovation points that the rehabilitation chair capable of moving the hands and the waist is arranged for a patient who does not coordinate or flexibly move the hands after the cranial neurosurgery operation, so that the patient can be subjected to rehabilitation treatment in advance, and the condition that the patient lies on a bed for a long time to cause haemorrhoids or thrombus is also avoided.

The present invention provides a method, device, equipment and medium for assessing brain nerve fatigue, which relates to the field of smart medical technology. The specific implementation method includes: in the process of visually guiding the assessment subject to perform multiple eye movement tests, collecting the assessment subject's multi-dimensional eye movement characteristics, and the multi-dimensional eye movement characteristics are controlled by different functional structures of the brain; inputting the multi-dimensional eye movement characteristics into a fatigue assessment neural network model, and the neural network model outputs a brain nerve fatigue assessment value. The fatigue assessment neural network model is a neural network model constructed based on a mesh mapping relationship of eye movement activity characteristics-brain structure-fatigue manifestations, and the fatigue manifestation is the change in eye movement activity characteristics when the brain nerves are fatigued. The present invention solves the problems of low efficiency of existing fatigue assessment methods, single assessment dimension, and one-sided judgment basis, improves the accuracy and reliability of the assessment, and realizes comprehensive, systematic and efficient fatigue monitoring.

Structural design of cranial nerve degeneration contrast agent precursor, the cranial nerve degeneration contrast agent prepared using the cranial nerve degeneration contrast agent precursor can be used for positron radiation tomography to detect alpha-synuclein. Since the cranial nerve degeneration contrast agent has better affinity and specificity for α-synuclein, it is helpful for more efficient early diagnosis of Parkinson's disease.

A neuromodulation system for treatment of physiological disorders. The system includes one or more stimulators for stimulating one or more cranial nerves; one or more detectors configured for detecting a predetermined physiological state; and a control unit that controls nerve stimulation by the one or more stimulators so that it is synchronized with the at least one predetermined physiological state detected by the one or more detectors. A method of neuromodulating a patient for treatment of physiological disorder. The method includes the steps of detecting a predetermined physiological state and applying stimulation to one of the cranial nerves during the predetermined physiological state by one or more stimulators of a neuromodulation system.

The invention relates to a multi-mode eye-brain collaborative maintenance intelligent device, and belongs to the technical field of eye-brain nursing equipment.The device is provided with an impression stimulation module, the impression stimulation module stimulates mild energy of an impression acupoint, the mild energy can be directly conducted to a paranasal sinus olfactory bulb in the deep part of a nasal cavity, the area is the starting end of paranasal sinus nerves, the paranasal sinus nerves are branches of cranial nerves, and therefore the paranasal sinus acupoint can be stimulated; the neural pathway directly extends to brain hippocampus, brain marginal tissue, pituitary gland and other core structures related to neuronutrition and brain metabolism; after stimulation, the paranasal sinus olfactory bulb and paranasal sinus nerves are activated to form a neural pathway for targeted delivery of the atomized liquid, so that the atomized particles of the brain care liquid are adsorbed on the surface of the paranasal sinus olfactory bulb and permeate into the brain along the activated neural pathway, and meanwhile, the permeability of the blood brain barrier is improved, so that the delivery resistance of the atomized liquid to related functional areas of the brain is further reduced, and the targeted delivery of the atomized liquid is realized. Precise nutrition for cranial nerves is achieved, and the problem that brain maintenance is invalid due to the fact that conventional nasal cavity atomized liquid enters the lung is thoroughly solved.

The invention belongs to the field of bioengineering and neurotoxicity prevention and control, and particularly relates to a neurotoxicity antagonist screening and evaluating method based on a microorganism-intestine-brain axis. The screening method of the neurotoxicity antagonist comprises the following steps: establishment of a neurotoxicity animal model, verification of the neurotoxicity model, sequencing of intestinal flora and screening of key flora, coupling analysis of flora-cranial nerve indexes, verification of candidate microorganisms, screening of core bacterial metabolites, verification of the core bacterial metabolites and verification of the core bacterial metabolites. According to the method, through behavior-neurotransmitter-inflammation-gene / mitochondrial function multi-level index linkage, a reproducible recovery index (RI) index is established, and quantitative screening and grading judgment of candidate strains and metabolites of the candidate strains on nerve injury repair are achieved.