134 results about "Cranial nerves" patented technology

The invention provides a surgical process management method and system, and relates to the technical field of surgical process management.The method comprises the steps that DTI, fMRI and 3D-T1WI image data are fused through a non-rigid registration algorithm, a three-dimensional brain network atlas is generated, then an LSTM deep learning model is constructed, a brain surface displacement field monitored in real time in an operation is used as input, and an LSTM deep learning model is constructed; a deep tissue displacement value is used as a label for training to obtain a deep tissue displacement predicted value, and a dynamic relation between brain neural element electrical activity and oxyhemoglobin saturation is analyzed by combining data monitored by high-frequency EEG and near infrared spectrum and utilizing a wavelet time-frequency coherence algorithm to obtain a dynamic influence coefficient; and finally, combining the deep tissue displacement predicted value with the dynamic influence coefficient, calculating a comprehensive evaluation index, and comparing the comprehensive evaluation index with a preset threshold value, so that a surgeon can quickly adjust an operation strategy and timely deal with possible risks.

The invention provides a cognitive function evaluation method based on neurovascular coupling analysis. The method comprises a signal preprocessing step, a signal processing step, a feature extraction step and a coupling coefficient calculation step. A new normal form of cognitive evaluation is constructed from nerve-blood vessel coupling and cross-system cooperation dimensions, and accurate description of a cognitive state is realized through real-time quantification of a dynamic cooperation effect of brain nerve activity (EEG) and blood flow regulation (CBP variability) and establishment of an association relationship between a dynamic cooperation index and cognitive ability (alertness, reaction speed and memory). And a new objective basis is provided for the fields of plateau medicine, intelligent health, neurological and mental disease diagnosis and treatment and the like.

The invention discloses an audio feature extraction method based on a cranial nerve model, and the method comprises the steps: obtaining voice signal data, carrying out the preprocessing of a voice signal, and segmenting the voice signal into N voice segments; extracting acoustic features representing emotional conditions from each voice segment, normalizing the acoustic features, and synthesizing the acoustic features into a multi-channel voice spectrogram; and inputting the multi-channel speech spectrogram into the RBA-FE model, outputting a BDI score, carrying out depression degree prediction classification according to the BDI score, adjusting parameters of each network layer in the RBA-FE model according to the difference between prediction classification and actual classification, and obtaining an optimal RBA-FE model to carry out depression degree detection. According to the method, the cell selectivity in the auditory cortex of the human brain is simulated, the problems of overfitting and non-noise resistance of the LSTM are solved by adopting a self-adaptive activation mechanism, and precise recognition of the depression voice under different noise interferences is realized.

The present invention relates to a helmet-type magnetic stimulation device for providing non-invasive treatment by applying a magnetic field to cranial nerve cells or scalp cells, the helmet-type magnetic stimulation device comprising: a helmet-type case part; a magnetic field generation part for generating a magnetic field in order to apply a magnetic field to the head; and a fixing part installed on one inner side of the case part to fix and support the magnetic field generation part at a predetermined position on the head. Therefore, the present invention includes a magnetic field generation part for generating a magnetic field in order to apply a magnetic field to the head, inside the case part.

The invention relates to a cranial nerve motor function evaluation system and method based on a terminal with a camera. The system comprises a camera used for collecting a high-definition video sequence of facial actions; the model is used for identifying positioning points of the face according to the high-definition video sequence acquired by the camera; the analysis and evaluation module is used for quantitatively evaluating the cranial nerve motor function state according to the change of the positioning points of the face acquired by the model; the analysis and evaluation module performs analysis and evaluation according to the change quantitative indexes of the positioning points of the face; the camera, the model and the analysis and evaluation module are all deployed at the terminal; and the model and the analysis and evaluation module are deployed in an operating system of the terminal. The evaluation system and method are deployed on a common terminal, and are used for collecting a video sequence of a user completing a standard evaluation action, automatically identifying the movement of a positioning point of a face, and outputting a quantitative score according to a medical standard so as to evaluate human face muscle movement and a cranial nerve function state.

The application provides a wireless and battery-free brain nerve stimulator and a preparation method. The brain nerve stimulator can be driven by a mobile phone loudspeaker, and a resonator designed can effectively amplify a piezoelectric signal. The brain nerve stimulator comprises two parts: a base provided with implantable nerve stimulation electrodes and a resonant cavity device connected through magnetic coupling. The design scheme of the brain nerve stimulator provides a general method for inhibiting epilepsy. The brain nerve stimulator can be extended to target brain deep layers or surface areas and peripheral nervous systems. A stimulation mode can be wirelessly transmitted and controlled. It is proved by electroencephalogram recording of free-moving mice that the wireless nerve stimulator can effectively relieve seizure events of the epileptic mice in vivo.

The present invention relates to the field of medical rehabilitation, and specifically discloses an upper limb cranial nerve rehabilitation training system and training method. The upper limb training control system includes: an information acquisition module that collects historical trainee upper limb motion trajectory information and upper limb training parameters based on a multidimensional sensor; a virtual reality and human-computer interaction module that displays a training virtual reality scene based on a trainee's head-mounted display, and controls a robot to drive the trainee's upper limb to perform motion based on the training virtual reality scene and controls the trainee's head-mounted speaker to feed back the robot training information; a trajectory tracking module that obtains the trainee's upper limb training feedback after human-computer interaction in real time, and tracks and follows the upper limb training movement trajectory in real time; a warning analysis module that analyzes the tracking results of the upper limb training movement trajectory and receives the trainee's upper limb training feedback and warnings; and a feedback module that adjusts the trainee's upper limb motion trajectory information based on the upper limb training feedback and updates a three-dimensional trajectory model.

Neurostimulation therapy can be efficiently controlled based on information from an acceleration signal, such as can be obtained from an accelerometer. In an example, the accelerometer can be implanted in a cervical region or submandibular region of a patient. Circuitry can be configured to identify a first series of respiration phase transition events in the acceleration signal and, in response, provide the neurostimulation therapy synchronously with an inspiration phase of a patient's respirator cycle. In an example, m absence of identifying the first series of respiration phase transition events in the acceleration signal, the neurostimulation therapy can be provided asynchronously with the patient's respiratory cycle.

The application discloses a cistema brain-computer interface-minimally invasive whole brain nerve signal acquisition and closed-loop control system based on a cerebrospinal fluid channel and a method thereof. The system comprises a flexible cistema interface array, an ultra-wideband wireless energy and data synchronous transmission module, a nerve signal analysis and decoding module, a self-adaptive closed-loop control module and a system integrated control platform. The flexible cistema interface array is implanted in a cerebrospinal fluid cavity in a minimally invasive manner to acquire multi-brain region nerve signals; and the ultra-wideband transmission module realizes energy supply and high-speed bidirectional communication between an implanted body and an extracorporeal device. The application solves the problems of a large trauma, limited coverage and poor signal quality of an existing invasive interface, has the advantages of minimally invasive, wide area coverage, high signal quality and good integration, and is suitable for diagnosis and treatment of neurological diseases such as epilepsy suppression and post-stroke motor function reconstruction.

To provide a mammalian epilepsy model.SOLUTION: A mammalian epilepsy model is obtained by a method comprising (i) injecting an RNA-interfering shRNA having a specific nucleic acid sequence of a nucleic acid encoding CREB-controlled transcriptional coactivator 1 into three or more different brain or cranial nerve regions of a mammal; or (ii) injecting an RNA-interfering shRNA having a specific nucleic acid sequence of a nucleic acid encoding CREB-controlled transcriptional coactivator 1 into two or more different brain or cranial nerve regions of a mammal and injecting an RNA-interfering shRNA having a specific nucleic acid sequence of a nucleic acid encoding CREB-controlled transcriptional coactivator 1 into one or more different brain or cranial nerve regions of a mammal.SELECTED DRAWING: None

The application discloses an indigo red derivative, a preparation method of the indigo red derivative, and application of the indigo red derivative in preparation of an anti-cerebral ischemia neuroprotective drug or a drug component. The indigo red derivative has good anti-cerebral ischemia neuroprotective activity, can overcome defects of existing active ingredients, such as easy bleeding, difficulty in penetrating a blood-brain barrier, poor oral bioavailability, low selectivity, and high neurobehavioral toxicity, and can be used as a cerebral neuroprotective active ingredient for treatment of ischemic cerebral stroke. According to an animal experiment of cerebral neuroprotective activity screening, it can be seen that after the compound is given preventively, the survival time of acute cerebral ischemia mice can be obviously prolonged, and the compound has good anti-cerebral ischemia neuroprotective effect.

To provide a system for stimulating cranial nerves.SOLUTION: A neuromodulation system for nerve adjustment of cranial nerves can be used to treat sleep or breathing disorders. The system can include a first housing configured to be implanted in a triangular region below a chin cap of a patient. The system can include a first electrode lead coupled to the first housing, and the first electrode lead can include an electrode configured to be disposed at or near a first cranial nerve target in the patient. The system can be provided with a signal generating circuit configured to generate electrical neuromodulation signals for delivery to the first cranial nerve target by using the electrode.SELECTED DRAWING: Figure 9

An organic sol-gel nano-composition containing three solid lipid nano-components loaded with phytochemical active ingredients is proposed. Panax notoginseng saponins are extracted from Vietnamese Panax notoginseng. Rutin is extracted from Styphnolobium japonicum in Thai Binh Province, Vietnam, and Ginkgo biloba is extracted from Ginkgo biloba trees. The composition has shown to have low toxicity and great bioavailability. In particular, the composition is effective against local myocardial ischemias and arrhythmias, improves the blood rheology, platelet circulation and antiaggregation, and thrombosis, lowers the blood lipids to a certain limit, and has good effects against atherosclerosis. The composition has an antioxidant effect of preventing free radical damages, and has an effect of enhancing capillary resistance, strengthening the vessel walls that reduces hypertension risks, which accordingly protects the cerebral nerves, prevents strokes, and is also used to recover after strokes and other hemorrhagic diseases for the enhancement effects and reconstruction of the damaged blood vessels.

The application provides an analgesia system based on brain nerve oscillation regulation, relates to the technical field of pain regulation, and first establishes a brain signal standardization information base of healthy people; for each pain patient, the brain nerve signal index of the pain patient is compared with a standard normal range obtained from the brain signal standardization information base of healthy people to determine abnormal electroencephalogram nerve indexes of each pain patient; then, according to the pain specificity of each pain patient, the correlation between the behavior indexes and the abnormal electroencephalogram nerve indexes of the pain patient is analyzed to determine potential regulation target points; the regulation target points to be intervened and regulation modes are selected from the potential regulation target points; different regulation modes are selected according to actual requirements to regulate the pain of the pain patient; and then, the pain regulation effect is evaluated, so that the effect of relieving pain is achieved, the analgesia system has the characteristics of safety, economy and easy operation, and is expected to be applied to the treatment of clinical pain.

The utility model discloses a cranial nerve patient postoperative rehabilitation chair which comprises a chair frame, a cushion, a backrest, armrest frames, a bidirectional motor, a rotating wheel, a shaft sleeve, a movable rod, movable armrests, a binding belt and a controller, and the armrest frames are arranged on the left side and the right side of the chair frame; the two-way motor is fixedly arranged at the bottom of the chair frame, a rotating wheel is fixedly arranged on a two-way output shaft of the two-way motor, and the shaft sleeve is rotatably arranged on the armrest frame; one end of the movable rod is rotatably connected with the non-circle-center position of the rotating wheel, and the other end of the movable rod penetrates through the shaft sleeve and is hinged with the movable handrail; the movable armrest is positioned above the armrest frame; binding belts are arranged on the movable armrests; and the controller is arranged at the bottom of the chair frame. The rehabilitation chair has the innovation points that the rehabilitation chair capable of moving the hands and the waist is arranged for a patient who does not coordinate or flexibly move the hands after the cranial neurosurgery operation, so that the patient can be subjected to rehabilitation treatment in advance, and the condition that the patient lies on a bed for a long time to cause haemorrhoids or thrombus is also avoided.

The present invention provides a method, device, equipment and medium for assessing brain nerve fatigue, which relates to the field of smart medical technology. The specific implementation method includes: in the process of visually guiding the assessment subject to perform multiple eye movement tests, collecting the assessment subject's multi-dimensional eye movement characteristics, and the multi-dimensional eye movement characteristics are controlled by different functional structures of the brain; inputting the multi-dimensional eye movement characteristics into a fatigue assessment neural network model, and the neural network model outputs a brain nerve fatigue assessment value. The fatigue assessment neural network model is a neural network model constructed based on a mesh mapping relationship of eye movement activity characteristics-brain structure-fatigue manifestations, and the fatigue manifestation is the change in eye movement activity characteristics when the brain nerves are fatigued. The present invention solves the problems of low efficiency of existing fatigue assessment methods, single assessment dimension, and one-sided judgment basis, improves the accuracy and reliability of the assessment, and realizes comprehensive, systematic and efficient fatigue monitoring.

Structural design of cranial nerve degeneration contrast agent precursor, the cranial nerve degeneration contrast agent prepared using the cranial nerve degeneration contrast agent precursor can be used for positron radiation tomography to detect alpha-synuclein. Since the cranial nerve degeneration contrast agent has better affinity and specificity for α-synuclein, it is helpful for more efficient early diagnosis of Parkinson's disease.

A neuromodulation system for treatment of physiological disorders. The system includes one or more stimulators for stimulating one or more cranial nerves; one or more detectors configured for detecting a predetermined physiological state; and a control unit that controls nerve stimulation by the one or more stimulators so that it is synchronized with the at least one predetermined physiological state detected by the one or more detectors. A method of neuromodulating a patient for treatment of physiological disorder. The method includes the steps of detecting a predetermined physiological state and applying stimulation to one of the cranial nerves during the predetermined physiological state by one or more stimulators of a neuromodulation system.

The invention relates to a multi-mode eye-brain collaborative maintenance intelligent device, and belongs to the technical field of eye-brain nursing equipment.The device is provided with an impression stimulation module, the impression stimulation module stimulates mild energy of an impression acupoint, the mild energy can be directly conducted to a paranasal sinus olfactory bulb in the deep part of a nasal cavity, the area is the starting end of paranasal sinus nerves, the paranasal sinus nerves are branches of cranial nerves, and therefore the paranasal sinus acupoint can be stimulated; the neural pathway directly extends to brain hippocampus, brain marginal tissue, pituitary gland and other core structures related to neuronutrition and brain metabolism; after stimulation, the paranasal sinus olfactory bulb and paranasal sinus nerves are activated to form a neural pathway for targeted delivery of the atomized liquid, so that the atomized particles of the brain care liquid are adsorbed on the surface of the paranasal sinus olfactory bulb and permeate into the brain along the activated neural pathway, and meanwhile, the permeability of the blood brain barrier is improved, so that the delivery resistance of the atomized liquid to related functional areas of the brain is further reduced, and the targeted delivery of the atomized liquid is realized. Precise nutrition for cranial nerves is achieved, and the problem that brain maintenance is invalid due to the fact that conventional nasal cavity atomized liquid enters the lung is thoroughly solved.

The invention belongs to the field of bioengineering and neurotoxicity prevention and control, and particularly relates to a neurotoxicity antagonist screening and evaluating method based on a microorganism-intestine-brain axis. The screening method of the neurotoxicity antagonist comprises the following steps: establishment of a neurotoxicity animal model, verification of the neurotoxicity model, sequencing of intestinal flora and screening of key flora, coupling analysis of flora-cranial nerve indexes, verification of candidate microorganisms, screening of core bacterial metabolites, verification of the core bacterial metabolites and verification of the core bacterial metabolites. According to the method, through behavior-neurotransmitter-inflammation-gene / mitochondrial function multi-level index linkage, a reproducible recovery index (RI) index is established, and quantitative screening and grading judgment of candidate strains and metabolites of the candidate strains on nerve injury repair are achieved.

To provide a material for treating encephalopathy, a method for treating encephalopathy, a material for regenerating brain neuron, and a method for regenerating brain neuron.MEANS: The present invention provides a material for treating encephalopathy or the like, containing a support fixed or coated with at least one selected from the group consisting of N-cadherin, a fusion protein containing the whole or some parts of N-cadherin, and a fusion protein containing the whole or some parts of a protein having homology with N-cadherin.SELECTED DRAWING: Figure 4

1. Name of the product of this design: Implantable Medical Device (PI01). 2. Purpose of the product of this design: A micro-device fixed on the skull as a brain-computer interface, used for brain nerve signal acquisition and / or neural stimulation treatment. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the key points of the design: Design 1 3D drawing. 5. Designate Design 1 as the base design.

Systems, devices and methods are provided for stimulating one or more cranial nerve(s) of a user. The systems and methods combine an electrical stimulation signal with an audio signal, such as music, white noise, ambient sound, filtered music, and the like. The combination of the nerve stimulation and the audio signal may be specifically designed to treat various diseases or disorders and / or for non-medical purposes, such as improving the general well-being of the user, reducing stress and the like. In certain embodiments, the electrical impulses comprise a burst stimulation and a tonic stimulation. The burst stimulation may comprise a burst of pulses. The bursts and / or the pulses may have frequencies that vary throughout the duration of the treatment.

The present invention relates to a composition for inducing differentiation of cranial neural crest stem cells into perivascular cells, a method for producing perivascular cells from cranial neural crest stem cells, and a cell therapeutic agent composition for preventing or treating brain nervous system diseases using the perivascular cells or bone diseases using the cranial neural crest stem cells. The composition and method for inducing differentiation of cranial neural crest stem cells into perivascular cells according to an aspect of the present invention enable the specific production of from cranial neural crest stem cells. In addition, the perivascular cells can be used as a cell therapeutic agent for brain nervous system diseases and using the cranial neural crest stem cells can be used as a cell therapeutic agent for bone diseases.

1. The name of this design product: brain nerve stimulation device. 2. Purpose of the product with this design: It is worn on the head, connected to a signal generator, and generates pulse signals to stimulate the brain nerves to treat diseases. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: Stereoscopic drawing 1.

The invention aims to provide a composition for protecting cerebral nerve cells. The present invention relates to a composition for protecting cerebral nerve cells, which is characterized by containing the following components (A) and (B): (A) lutein and / or a fatty acid ester thereof; (B) a docosahexaenoic acid compound, wherein the weight ratio ((B) / (A)) of the component (B) (in terms of docosahexaenoic acid) to the component (A) (in terms of lutein) is 10-120.

The invention relates to the technical field of functional foods, and particularly discloses a dietary therapy composition for promoting repair of cranial nerve damaged cells and a preparation method. The composition is prepared from the following raw materials in parts by weight: artichoke peptide, taurine, phosphatidylserine, natural nicotinic acid, guarana extract, collagen peptide, acerola cherry fruit powder, inulin, yak bone marrow powder, vitamin B family, sialic acid and sucralose. The preparation method comprises the following steps: S1, pretreating the raw materials; s2, performing nano crushing; s3, low-temperature drying; s4, embedding the inulin; and S5, mixing and forming. The artichoke peptide and the phosphatidylserine are synergistically matched, and a compound component with liver and brain axis functions is taken into consideration, so that a multi-target synergistic effect is achieved, the requirements of cell repair and neural development are synchronously met, and compared with single-component supplement or neglect of the influence of liver detoxification on brain repair in the prior art, the brain repair effect is greatly improved. The problems of low repairing efficiency and insufficient component utilization rate are solved.

The present application relates to the technical field of medical equipment, in particular to an external counterpulsation instrument. It comprises: an electrocardiogram detection module, an electroencephalogram detection module, a magnetic stimulation intelligent device module and a central processing unit module. The electrocardiogram detection module is used for measuring the electrocardiogram pulse signal of the human body to be measured; the electroencephalogram detection module is used for detecting the brain wave signal of the brain of the human body to be measured; the central processing unit module is used for receiving the electrocardiogram pulse signal and the brain wave signal, and comprehensively analyzing and processing the electrocardiogram pulse signal and the brain wave signal to obtain the frequency and timing information of the human heart contraction, and obtaining the corresponding magnetic stimulation trigger signal according to the frequency and timing information of the heart contraction; the magnetic stimulation intelligent device module is used for receiving the magnetic stimulation trigger signal and generating the corresponding magnetic stimulation signal under the triggering of the magnetic stimulation trigger signal, so as to perform magnetic stimulation processing on the human body to be measured. The present application stimulates the human muscle nerves and brain nerves by using the magnetic field, and achieves the same treatment effect as the conventional air pressure type external counterpulsation instrument.

The present invention relates to a composition for improving memory, improving cognition, preventing or treating cerebral neurological disease, comprising porcine brain enzyme hydrolysate. The composition can exhibit neuroprotective activity, brain-derived neurotrophic factor (BDNF) production activity, acetylcholinesterase inhibitory activity and reactive oxygen species (ROS) inhibitory activity.