74 results about "Cranial nerves" patented technology

The present invention relates to a helmet-type magnetic stimulation device for providing non-invasive treatment by applying a magnetic field to cranial nerve cells or scalp cells, the helmet-type magnetic stimulation device comprising: a helmet-type case part; a magnetic field generation part for generating a magnetic field in order to apply a magnetic field to the head; and a fixing part installed on one inner side of the case part to fix and support the magnetic field generation part at a predetermined position on the head. Therefore, the present invention includes a magnetic field generation part for generating a magnetic field in order to apply a magnetic field to the head, inside the case part.

The application provides a wireless and battery-free brain nerve stimulator and a preparation method. The brain nerve stimulator can be driven by a mobile phone loudspeaker, and a resonator designed can effectively amplify a piezoelectric signal. The brain nerve stimulator comprises two parts: a base provided with implantable nerve stimulation electrodes and a resonant cavity device connected through magnetic coupling. The design scheme of the brain nerve stimulator provides a general method for inhibiting epilepsy. The brain nerve stimulator can be extended to target brain deep layers or surface areas and peripheral nervous systems. A stimulation mode can be wirelessly transmitted and controlled. It is proved by electroencephalogram recording of free-moving mice that the wireless nerve stimulator can effectively relieve seizure events of the epileptic mice in vivo.

The application discloses a cistema brain-computer interface-minimally invasive whole brain nerve signal acquisition and closed-loop control system based on a cerebrospinal fluid channel and a method thereof. The system comprises a flexible cistema interface array, an ultra-wideband wireless energy and data synchronous transmission module, a nerve signal analysis and decoding module, a self-adaptive closed-loop control module and a system integrated control platform. The flexible cistema interface array is implanted in a cerebrospinal fluid cavity in a minimally invasive manner to acquire multi-brain region nerve signals; and the ultra-wideband transmission module realizes energy supply and high-speed bidirectional communication between an implanted body and an extracorporeal device. The application solves the problems of a large trauma, limited coverage and poor signal quality of an existing invasive interface, has the advantages of minimally invasive, wide area coverage, high signal quality and good integration, and is suitable for diagnosis and treatment of neurological diseases such as epilepsy suppression and post-stroke motor function reconstruction.

To provide a system for stimulating cranial nerves.SOLUTION: A neuromodulation system for nerve adjustment of cranial nerves can be used to treat sleep or breathing disorders. The system can include a first housing configured to be implanted in a triangular region below a chin cap of a patient. The system can include a first electrode lead coupled to the first housing, and the first electrode lead can include an electrode configured to be disposed at or near a first cranial nerve target in the patient. The system can be provided with a signal generating circuit configured to generate electrical neuromodulation signals for delivery to the first cranial nerve target by using the electrode.SELECTED DRAWING: Figure 9

The application provides an analgesia system based on brain nerve oscillation regulation, relates to the technical field of pain regulation, and first establishes a brain signal standardization information base of healthy people; for each pain patient, the brain nerve signal index of the pain patient is compared with a standard normal range obtained from the brain signal standardization information base of healthy people to determine abnormal electroencephalogram nerve indexes of each pain patient; then, according to the pain specificity of each pain patient, the correlation between the behavior indexes and the abnormal electroencephalogram nerve indexes of the pain patient is analyzed to determine potential regulation target points; the regulation target points to be intervened and regulation modes are selected from the potential regulation target points; different regulation modes are selected according to actual requirements to regulate the pain of the pain patient; and then, the pain regulation effect is evaluated, so that the effect of relieving pain is achieved, the analgesia system has the characteristics of safety, economy and easy operation, and is expected to be applied to the treatment of clinical pain.

A neuromodulation system for treatment of physiological disorders. The system includes one or more stimulators for stimulating one or more cranial nerves; one or more detectors configured for detecting a predetermined physiological state; and a control unit that controls nerve stimulation by the one or more stimulators so that it is synchronized with the at least one predetermined physiological state detected by the one or more detectors. A method of neuromodulating a patient for treatment of physiological disorder. The method includes the steps of detecting a predetermined physiological state and applying stimulation to one of the cranial nerves during the predetermined physiological state by one or more stimulators of a neuromodulation system.

The invention relates to a multi-mode eye-brain collaborative maintenance intelligent device, and belongs to the technical field of eye-brain nursing equipment.The device is provided with an impression stimulation module, the impression stimulation module stimulates mild energy of an impression acupoint, the mild energy can be directly conducted to a paranasal sinus olfactory bulb in the deep part of a nasal cavity, the area is the starting end of paranasal sinus nerves, the paranasal sinus nerves are branches of cranial nerves, and therefore the paranasal sinus acupoint can be stimulated; the neural pathway directly extends to brain hippocampus, brain marginal tissue, pituitary gland and other core structures related to neuronutrition and brain metabolism; after stimulation, the paranasal sinus olfactory bulb and paranasal sinus nerves are activated to form a neural pathway for targeted delivery of the atomized liquid, so that the atomized particles of the brain care liquid are adsorbed on the surface of the paranasal sinus olfactory bulb and permeate into the brain along the activated neural pathway, and meanwhile, the permeability of the blood brain barrier is improved, so that the delivery resistance of the atomized liquid to related functional areas of the brain is further reduced, and the targeted delivery of the atomized liquid is realized. Precise nutrition for cranial nerves is achieved, and the problem that brain maintenance is invalid due to the fact that conventional nasal cavity atomized liquid enters the lung is thoroughly solved.

The invention belongs to the field of bioengineering and neurotoxicity prevention and control, and particularly relates to a neurotoxicity antagonist screening and evaluating method based on a microorganism-intestine-brain axis. The screening method of the neurotoxicity antagonist comprises the following steps: establishment of a neurotoxicity animal model, verification of the neurotoxicity model, sequencing of intestinal flora and screening of key flora, coupling analysis of flora-cranial nerve indexes, verification of candidate microorganisms, screening of core bacterial metabolites, verification of the core bacterial metabolites and verification of the core bacterial metabolites. According to the method, through behavior-neurotransmitter-inflammation-gene / mitochondrial function multi-level index linkage, a reproducible recovery index (RI) index is established, and quantitative screening and grading judgment of candidate strains and metabolites of the candidate strains on nerve injury repair are achieved.

Systems, devices and methods are provided for stimulating one or more cranial nerve(s) of a user. The systems and methods combine an electrical stimulation signal with an audio signal, such as music, white noise, ambient sound, filtered music, and the like. The combination of the nerve stimulation and the audio signal may be specifically designed to treat various diseases or disorders and / or for non-medical purposes, such as improving the general well-being of the user, reducing stress and the like. In certain embodiments, the electrical impulses comprise a burst stimulation and a tonic stimulation. The burst stimulation may comprise a burst of pulses. The bursts and / or the pulses may have frequencies that vary throughout the duration of the treatment.

The invention relates to the technical field of functional foods, and particularly discloses a dietary therapy composition for promoting repair of cranial nerve damaged cells and a preparation method. The composition is prepared from the following raw materials in parts by weight: artichoke peptide, taurine, phosphatidylserine, natural nicotinic acid, guarana extract, collagen peptide, acerola cherry fruit powder, inulin, yak bone marrow powder, vitamin B family, sialic acid and sucralose. The preparation method comprises the following steps: S1, pretreating the raw materials; s2, performing nano crushing; s3, low-temperature drying; s4, embedding the inulin; and S5, mixing and forming. The artichoke peptide and the phosphatidylserine are synergistically matched, and a compound component with liver and brain axis functions is taken into consideration, so that a multi-target synergistic effect is achieved, the requirements of cell repair and neural development are synchronously met, and compared with single-component supplement or neglect of the influence of liver detoxification on brain repair in the prior art, the brain repair effect is greatly improved. The problems of low repairing efficiency and insufficient component utilization rate are solved.

The present invention relates to a composition for improving memory, improving cognition, preventing or treating cerebral neurological disease, comprising porcine brain enzyme hydrolysate. The composition can exhibit neuroprotective activity, brain-derived neurotrophic factor (BDNF) production activity, acetylcholinesterase inhibitory activity and reactive oxygen species (ROS) inhibitory activity.

The invention discloses a dietary therapy formula for repairing damaged cells and promoting cranial nerve development and a preparation method, and the dietary therapy formula comprises the following components in parts by weight: 1-2 parts of bone collagen peptide, 1-2 parts of taurine, 1-2 parts of bovine bone marrow powder, 2-4 parts of inulin, 2-4 parts of acerola cherry fruit powder, 3-4 parts of guarana extract and 4-6 parts of N-acetylneuraminic acid. 4-5 parts of vitamin B6, 2-4 parts of vitamin B1 and 2-4 parts of vitamin B2; the traditional Chinese medicine composition is capable of repairing damaged cells and promoting cranial nerve development, and has remarkable effects of inhibiting the onset of neurological diseases, promoting the repair of nerve cells and promoting nerve development.

1. The name of the design product: non-invasive brain nerve stimulator. 2. The use of the design product: the design product is used for non-invasive electrical stimulation of the central nervous system in the head, promoting brain function regulation and recovery. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

1. The name of the design product: insomnia treatment instrument of transcranial magnetic. 2. The use of the design product: for stimulating the cerebral cortex by magnetic field, adjusting the brain nerve activity. 3. The design points of the design product: in shape. 4. The picture or photo that can best show the design points: perspective drawing.

To appropriately support participants' exercise during remote training or rehabilitation. [Solution] The control unit 40 includes a display control unit 41 that displays a model video of exemplary body movements on the display unit 31, a movement determination unit 44 that determines the difference between the participant's movements, which are performed in accordance with the model video displayed on the display unit 31, and the model video, a mind-body state estimation unit 45 that estimates the participant's mind-body state based on the participant's biological information, a factor estimation unit 46 that estimates the cause of the difference based on the type of difference and the participant's mind-body state if the movement determination unit 44 determines that there is a difference, and a stimulus determination unit 47 that determines the type and method of stimulus to be given to the participant in order to promote a change in at least one of the participant's visual system function, brain-nerve system function, and muscular system function, based on the estimation result of the factor estimation unit 46.

The invention discloses a dietary therapy formula for repairing damaged cells and promoting cranial nerve development and a preparation method, and the dietary therapy formula comprises the following components in parts by weight: 1-2 parts of bone collagen peptide, 1-2 parts of taurine, 1-2 parts of bovine bone marrow powder, 2-4 parts of inulin, 2-4 parts of acerola cherry fruit powder, 3-4 parts of guarana extract and 4-6 parts of N-acetylneuraminic acid. 4-5 parts of vitamin B6, 2-4 parts of vitamin B1 and 2-4 parts of vitamin B2; the traditional Chinese medicine composition is capable of repairing damaged cells and promoting cranial nerve development, and has remarkable effects of inhibiting the onset of neurological diseases, promoting the repair of nerve cells and promoting nerve development.

Disclosed are a composition and method for inhibiting tau protein accumulation, aggregation, or tangle, the composition containing neurons or glia having Nurr1 and / or Foxa2 genes introduced thereinto, wherein the composition and method can be utilized in the prevention or treatment of a cerebral nervous disease caused by tau protein accumulation, aggregation, or tangle formation.

The invention discloses a child cerebral palsy cranial nerve injury assessment instrument and method based on big data, and relates to the field of child cerebral palsy brain, the child cerebral palsy cranial nerve injury assessment instrument comprises a first supporting plate fixed at the upper end of a mounting frame, and a placement assembly is fixed on the upper surface of the first supporting plate; the device further comprises a moving assembly fixed above the placing assembly and a collecting assembly arranged on one side of the placing assembly. The collecting assembly is pushed into the oral cavity of a patient through the moving assembly for tongue surface image collection, and the light supplementing module fixed to the surface of the collecting assembly simulates natural light, so that in the process that the collecting module collects the image in the oral cavity, the influence of the dark environment in the oral cavity on image collection is reduced; meanwhile, the tongue surface is fixed through the tongue depressor, movement and reflection of the tongue can be restrained, the tongue root can be further exposed, and completeness and clearness of the tongue root image are improved.

The application discloses a kind of brain neuron wide-field single-photon calcium imaging method and system, wherein brain neuron wide-field single-photon calcium imaging method includes the following steps: from the reference frame image of continuous multiple frames of brain nerve image, reference frame image is divided into multiple overlapping subareas;From the brain nerve image of continuous multiple frames, one frame image is selected as current frame image one by one, and current frame image is divided into multiple overlapping subareas, each subarea corresponds with the size and position of the subarea of reference frame image;The displacement vector of the subarea of corresponding position on current frame image and reference frame image is calculated respectively using optical flow method;Whether all displacement vectors are consistent is judged, if yes, brain blood vessel features are used for image registration to remove motion artifact, if not, NorMCorre algorithm is used to remove motion artifact.Displacement state is analyzed first before image registration, and appropriate registration method is selected according to displacement state, which improves registration accuracy.

The invention relates to the field of medical devices and more specifically the field of medical technologies related to cerebral neuromodulation. The device is a tamper-proof electrode for transcranial neuromodulation, the design of which prevents the patient from manipulating the electrodes once they have been positioned, ensuring that the treatment is properly carried out.

The invention provides a brain nerve focus directional precise regulation and control device. The brain nerve focus directional precise regulation and control device comprises an SEEG detection device, a TI stimulation generation device and a switching device. The SEEG detection device is connected with the switching device, and the TI stimulation generation device is connected with the switching device; the switching device is connected with a multi-contact SEEG electrode array; the multi-contact SEEG electrode array is switched to be connected with the SEEG detection device or the TI stimulation generation device through the switching device; the SEEG detection device forms a three-dimensional detection network through the multi-contact SEEG electrode array, and the TI stimulation generation device forms a TI stimulation network through the multi-contact SEEG electrode array. The SEEG detection instrument is combined with the TI stimulation generation instrument, the SEEG detection instrument and the SEEG electrode array are used for recording, detecting and positioning the electrical activity of the epileptic area, the TI stimulation generation instrument is used for stimulating the EZ area of the epileptic, and the purposes of regulation and treatment are achieved without craniotomy.

A system for noninvasive neuromodulation of brain regions is provided. The system includes, one or more ultrasound transducers configured to deliver ultrasonic stimulation energy to an intended deep brain region and a transcranial magnetic stimulation (TMS) coil configured to deliver magnetic stimulation energy to an intended superficial cortical region. The system is configured to deliver the ultrasonic stimulation to a deep brain region and the magnetic stimulation to a superficial brain region. The intended deep brain region and intended superficial cortical region are a pairing corresponding to a neurological or psychological disorder.

To provide a system for stimulating cranial nerves.SOLUTION: A neuromodulation system for nerve adjustment of cranial nerves can be used to treat sleep or breathing disorders. The system can include a first housing configured to be implanted in a triangular region below a chin cap of a patient. The system can include a first electrode lead coupled to the first housing, and the first electrode lead can include an electrode configured to be disposed at or near a first cranial nerve target in the patient. The system can be provided with a signal generating circuit configured to generate electrical neuromodulation signals for delivery to the first cranial nerve target by using the electrode.SELECTED DRAWING: Figure 9

The present disclosure provides methods for generating midbrain dopamine neurons and their precursors, midbrain dopamine neurons and their precursors generated by such methods, compositions comprising such cells, and uses thereof for preventing, modeling, and / or treating neurological disorders. In certain embodiments, contacting the cells with at least one inhibitor of Wnt signaling begins at least about 5 days after initial contacting of the stem cells with at least one inhibitor of SMAD signaling.

This invention provides a composite composition containing nervonic acid and its use in brain nerve repair, belonging to the field of biotechnology. The invention uses nervonic acid and phosphatidylserine, combined with plant extracts fermented by a microbial concoction of *Lactobacillus acidophilus*: *Lactobacillus rhamnosus*: *Bacillus belyssae* = (2-3):1:1, to form a composite composition. This scientific formulation achieves synergistic effects from multiple components, improving neurological deficits, reducing cerebral infarction volume, decreasing the release of neurotrophic markers, and upregulating neurotrophic factor expression through multi-target synergistic effects. Furthermore, this synergistic effect depends on specific component ratios, providing crucial experimental support for the development of subsequent brain-protective functional compositions. This composition can be widely applied to the preparation of brain nerve repair drugs, functional foods, and dietary supplements, possessing promising industrialization prospects and clinical value.

The invention discloses a use method of a flexible gravity center transfer trainer. The flexible gravity center transfer trainer comprises a gravity center transfer mechanism, a gravity center transfer detection device, a gravity center transfer display device and a gravity center transfer player. During use, a patient stands on the pedal and steps on the pedal to swing left and right, gravity center transfer data of the patient is detected through the gravity center transfer detection device of the gravity center transfer controller, electronic data is displayed through the gravity center transfer display device, and the patient feeds back the gravity center transfer data of self training to the brain of the patient by seeing the gravity center transfer data of self training and sends a movement instruction to limbs through the brain. The cranial nerves are used for commanding leg and foot movement through the central nervous system, the hemiplegic leg and foot movement is repeatedly trained, the patient is helped to gradually recover the movement capacity of hemiplegic limbs, and the training and rehabilitation effect is improved; when being used as fitness equipment, the pedal is treaded by two feet to swing left and right, so that ligaments and muscle groups of lower limbs, the waist, the abdomen and upper limbs are exercised, and the problem of exercising the body at home of old people is solved; meanwhile, music is played through the gravity center transfer player, the pedal is stepped to swing according to the rhythm of the music, and the exercise fun is increased.

The invention provides a novel method for preparing a fish otolith specimen, and belongs to the field of biological specimen preparation. Comprising the steps of specimen fixation, head skin dissection and segmentation, head muscle dissection and segmentation, head skeleton exposure and dissection, muscle dissection, dehydration, degreasing, polymer infiltration, fixation, solidification and the like. More importantly, the spatial position relation and the connection mode of the otolith, the skull, the brain, the nerve and the muscle system are displayed in situ. The otolith can be processed in a non-destructive mode, the otolith can be taken out or put back, the flexible display effect that the same specimen can display the details of the otolith and can also display overall dissection association is achieved, and the teaching and scientific research value of the specimen is greatly improved.

The present disclosure relates to a brain nerve function damage detection method and device, an electronic device and a storage medium. The brain nerve function damage detection method comprises: obtaining a brain tissue region of a brain perfusion image; extracting a dynamic image feature of the brain tissue region; obtaining a first feature for a first target and a second feature for a second target based on the dynamic image feature, the first target being whether suffering from a stroke, and the second target being an evaluation index of a brain function damage degree; and determining whether the brain nerve function is damaged based on the first feature and the second feature. The embodiment of the present disclosure can realize automatic detection of brain nerve function damage and improve detection accuracy.

The head-mounted cranial nerve stimulation device comprises a head-mounted support and two groups of stimulation assemblies, the head-mounted support comprises two adjusting parts and an adjusting belt, the two adjusting parts are respectively arranged at two ends of the adjusting belt, and each adjusting part is movably connected with the adjusting belt; and each group of stimulation components is rotationally connected to one adjusting part. During use, the position of the stimulation assembly relative to the adjusting belt is changed by moving the position of the adjusting part relative to the adjusting belt. The angle of the stimulation assembly is adjusted by rotating the stimulation assembly, so that the stimulation assembly is attached to the head of the user. Thus, through the adjusting part and the stimulation assembly, the head-mounted cranial nerve stimulation device is adjustable to adapt to the heads of different users, so that the head-mounted cranial nerve stimulation device achieves a better stimulation effect.