18 results about "Plexus" patented technology

The invention relates to the technical field of medical robot systems, and discloses a nerve plexus intelligent positioning anesthesia puncture robot system based on multi-modal fusion, which performs time-space synchronization on ultrasonic image flow and contact force data. The frequency domain analysis module extracts a main peak frequency by using optical flow field frequency domain transformation, and generates a probability mask for marking pulsatile tissues. The viscoelasticity verification module calculates phase lag parameters of visual deformation and contact force, identifies tissue rheological properties and calculates a dynamic damping coefficient. The deformation compensation module calculates a mechanical residual error based on a reference mechanical model, and inversely calculates the mechanical residual error into space deformation displacement of the tissue. The feedback control module combines the probability mask and the deformation displacement to generate a motion instruction. According to the invention, through multi-modal data fusion, precise identification of tiny blood vessels, dynamic identification of tissue attributes and real-time compensation of soft tissue conceding deformation are realized.

The invention relates to a convenient preparation tool for palatal side free gingiva and a use method thereof, the convenient preparation tool comprises a disposable handle and a head cutting device, the disposable handle is rigidly connected with the head cutting device, the head cutting device comprises a cutting module and a collecting channel, the collecting channel is arranged behind the cutting module, and the collecting channel is connected with the disposable handle. The cutting module comprises a horizontal blade and a vertical blade, the instrument can adapt to the anatomical form of the curved surface of the palate in the cutting process through the width limiting and arc design of the horizontal blade, the width is controllable, and the influence of subjectivity of an operator on the quality of a prepared graft is reduced; through height limitation of the vertical blades on the two sides, the stable cutting depth is maintained, the thickness uniformity of the graft is remarkably improved, the edge integrity of the graft is kept, the problem that the graft is broken or too thin due to angle deviation or uneven force application in traditional operation is solved, meanwhile, accidental injuries to deep vascular nerve plexus are reduced, and the survival rate of the graft is increased. And the risk of complications such as postoperative bleeding, pain and donor healing delay is reduced.

The embodiment of the invention provides an image recognition and micro-current detection method and system for intercostal nerve plexus avoidance, and belongs to the technical field of data processing. The method comprises the steps of collecting initial image information corresponding to a first target object, and performing edge detection on the initial image information to obtain a corresponding target recognition result; determining a corresponding current parameter during micro-current detection, and obtaining a corresponding reaction potential signal of a related area of the first target object under the current parameter; performing nerve classification according to the reaction potential information to obtain a target nerve type corresponding to the related area; aligning the related area with the initial image information to obtain a target alignment result, and determining related edge information corresponding to the related area according to the target alignment result and the target recognition result; and generating intercostal nerve plexus avoidance information according to the target nerve type and the related edge information, and displaying the intercostal nerve plexus avoidance information to a second target object.

The present invention relates to an artificial heart valve, which comprises a valve stent, a first sealing membrane, a second sealing membrane, valve leaflets and valve leaflet anchoring members. The valve stent includes an inflow section and an outflow section; the first sealing membrane is attached to the outer side of the valve stent and comprises a hydrophilic swelling material, which can absorb liquid and swell after contacting with blood, for reducing paravalvular leakage; the second sealing membrane is arranged on the outer side of the first sealing membrane and at least covers all regions corresponding to the outer surface of the inflow section, for increasing the friction with the native valve leaflets; the valve leaflets are arranged inside the valve stent for controlling the unidirectional flow of blood; the valve leaflet anchoring members are spiral and can be coiled outside the mitral / tricuspid chordae tendineae plexus and interact with the valve stent. By providing the first sealing membrane and the second sealing membrane, the artificial heart valve of the present invention can better fit with the native tissue after being implanted into the mitral / tricuspid valve, so as to effectively prevent the occurrence of paravalvular leakage.

The present disclosure relates to fluorinated phenylamino compounds, pharmaceutical compositions thereof, and methods of treating a tumor or cancer selected from the group consisting of plexiform neurofibroma (PN), plexiform neurofibroma associated with neurofibromatosis type 1 (NF1-PN), cutaneous neurofibroma (cNF), pancreatic ductal adenocarcinoma (PDAC), high-grade glioma (HGG), low-grade ovarian cancer, tuberous sclerosis (TSC), Langerhans cell histiocytosis (LCH), brain tumor, and cancer metastasized to the brain of a patient, comprising administering these pharmaceutical compositions to a patient in need thereof.

The application discloses an interpretable tongue diagnosis auxiliary diagnosis system based on knowledge graph fusion reasoning. The system obtains tongue diagnosis image data containing at least tongue surface image and sublingual plexus image, determines a plurality of preset tongue diagnosis regions and generates regional node features; constructs an image graph and updates the image graph by a first graph neural network to obtain image node features; constructs a traditional Chinese medicine knowledge graph containing tongue image, pathological factors, viscera, syndrome nodes and their relationships and updates the knowledge graph by a second graph neural network to obtain knowledge node features, projects and maps the image node features and the tongue image node features to the same embedding space, aligns the cross-modal modes according to a contrast learning loss to obtain cross-modal correlation; constructs a fusion graph based on the image graph, the knowledge graph and the cross-modal correlation and performs graph reasoning to output syndrome results and reasoning path information. Explicit connection of image regions and traditional Chinese medicine semantics and output of traceable paths reduce experience dependence and enhance interpretation and review.

The invention relates to a method for providing control data for an ophthalmic laser (12) of a treatment device (10), wherein the method comprises the following steps performed by a control unit (18): receiving anatomical data relating to the anatomy of a cornea (16) of an eye to be treated; determining the position of the corneal nerve plexus (24) in the cornea (16) based on the anatomical data of the cornea (16) to be treated; determining the depth distribution of the corneal nerve plexus (24) in the cornea (16); receiving cutting instructions for performing a cut (26) in the cornea (16) by the ophthalmic laser (12) of the treatment device (10); Determining a target depth (28) for the laser (12) to perform the cut (26) based on the cut specifications and the depth distribution of the corneal nerve plexus (24) according to a specified cut depth specification;and generating control data for controlling the ophthalmic laser (12) to perform the cut (26) in the cornea (16).;

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating radiation proctitis and a preparation method thereof.The traditional Chinese medicine composition is prepared from rhizoma coptidis processed with wine, radix scutellariae slices, radix rehmanniae recen, baked ginger, rhizoma atractylodis macrocephalae fried with bran, carbonized sanguisorba root, the root of Chinese pulsatilla, rhizoma bletillae, the root of kudzu vine, astragalus membranaceus, carbonized hair, honey-fried licorice root, radix paeoniae alba and rhizoma nelumbinis charcoal. According to the principle of clearing heat, promoting diuresis, detoxifying, cooling blood, dispersing blood stasis and stopping bleeding in traditional Chinese medicine, the pathological states of internal exuberance of fire-heat toxins and burns intestinal collaterals are comprehensively conditioned. Clinical research proves that the medicine can improve the traditional Chinese medicine syndrome score of patients suffering from stomachache, diarrhea, mucous bloody stool type rectum mucosa edema, hyperemia, bleeding and even ulceration and ulceration caused by radiotherapy, has practical popularization and application value, and is worthy of popularization and application. Therefore, the problems that the existing western medicine for treating radiation proctitis can only temporarily relieve symptoms, cannot repair intestinal mucosa injury and is easy to cause drug resistance and intestinal flora imbalance are solved.

Blood flow to the kidney primarily comes from the renal arteries which are controlled by the renal plexus. This plexus is innervated by the sympathetic chain and dorsal root ganglion upstream. In this embodiment neuromodulation of dorsal root ganglion between T8 and L3 can be used to alter renal blood flow and, thus, blood pressure. The neuromodulation at at frequencies between 0.01 Hz and 19.99 Hz at these DRG levels can be used to increase blood flow to the kidneys and to treat hypertension.

This disclosure relates generally to electrically stimulating dilators for selectively stimulating nerves during surgical procedures. A dilator for use in surgery includes a body extending from a proximal end to a distal end, with a clip attachment area at the proximal end of the body for receiving a stimulating clip. The clip attachment area includes an anterior electrode and a posterior electrode, the anterior electrode and posterior electrode insulated from each other. The dilator also includes a first conductive pathway extending from the anterior electrode to the distal end of the body and a second conductive pathway extending from the posterior electrode to the distal end of the body. An anterior emitter is at a distal end of the first conductive pathway and a posterior emitter is at a distal end of the second conductive pathway, with the posterior emitter disposed opposite the anterior emitter.

The utility model belongs to the field of the vein physiotherapy technology, concretely relates to a negative pressure vein physiotherapy appearance, including physiotherapy appearance main part, the one side of physiotherapy appearance main part is connected with negative pressure pipe and is provided, the output end of negative pressure pipe is connected with the adapter of setting up, the downside of adapter is provided with tin. Negative pressure pipe steady sleeve connection in the outside of cannula one, need not often dismount, it is convenient to guarantee the stability of negative pressure pipe, when needing to replace different tins, cover sleeve connection in the outside of sealing disc, through snap ring and recess clamping, cannula two tightly inserts in the inside of sleeve, realize with the intercommunication of negative pressure pipe, through control panel start micro -vibration motor, need not specially replace vibration tin, all kinds of tins can realize vibration when needing, and only need production time, guarantee different kinds and model tin sealing disc size corresponding cover unchange, namely can quick replacement and adaptation different tins, greatly increase the convenience of replacing tin.

This disclosure relates to an oral dosage form (such as a capsule) comprising (a) mildametinib having a d90 of 250 microns or less, a d50 of 50 microns or less, or both, and (b) one or more pharmaceutically acceptable pharmaceutical excipients. Such dosage forms are useful in the treatment of tumors and cancers (such as plexus neurofibroma (PN), plexus neurofibroma associated with neurofibromatosis type 1 (NF1-PN), high-grade glioma (HGG), low-grade ovarian cancer, Langerhans cell histiocytosis (LCH), brain cancer, and cancers that have metastasized to the patient's brain). This disclosure also relates to improved dosage regimens for mildametinib treatment.

Disclosed are compositions and methods for the treatment of hydrocephalus, for example pediatric hydrocephalus. The disclosed methods employ a non-surgical tool that may be used to control CSF production rate by inducing choroid plexus-specific apoptosis. In aspects, the non-surgical tools employ an AAV vector, a promoter, a suicide gene, and a suicide gene activator to achieve targeted choroid-plexus ablation and subsequent reduction of CSF volume.

The invention relates to the technical field of Alzheimer's disease treatment, in particular to application of collateral plexus overexpression in Alzheimer's disease treatment. The application comprises application of collateral plexus overexpression in treatment of Alzheimer's disease; the invention relates to application of venation plexus overexpression in reduction of beta-amyloid protein diffusion. According to the invention, the choice of a special target of the collateral plexus can become a new target for AD treatment, whether apoE synthesized by epithelial cells of the collateral plexus and secreted into cerebrospinal fluid participates in the disease process of AD or not is disclosed, the relation between the apoE of the collateral plexus and brain parenchyma A beta is disclosed, and a new thought can be opened for prevention and treatment of the Alzheimer's disease; according to the method, the influence of apoE4 overexpression and knock-down in the collateral cluster on brain parenchyma A beta is explored, and a new thought is possibly provided for reducing A beta diffusion so as to relieve AD (Alzheimer's disease).

The present disclosure relates to an oral dosage form, such as a capsule, comprising (a) midametinib having a d90 of not more than 250 microns, a d50 of not more than 50 microns, or both, and (b) one or more pharmaceutically acceptable excipients. These dosage forms are useful for the treatment of tumors and cancers, such as plexus neurofibroma (PN), plexus neurofibroma associated with type 1 neurofibromatosis (NF1-PN), high-grade glioma (HGG), low-grade ovarian cancer, Langerhans cell tissue cell hyperplasia (LCH), brain cancer, and cancer that has metastatic to the brain of a patient. The present disclosure also relates to an improved dosage regimen for midametinib treatment.

The invention relates to a transcatheter heart valve repair assembly and system. The transcatheter heart valve repair assembly comprises a fishing ring and a plugging frame. The fishing ring is spiral, can be axially compressed and is used for being wound outside the valve chordae tendineae; the plugging frame can be switched between a radial collapsing structure and a radial expanding structure, and the plugging frame is sequentially provided with a skirt edge part, a main body part and a connecting part from the blood inflow end to the blood outflow end; the skirt edge part extends outwards in the radial direction and is used for being attached to the side wall of the atrium and sealing the valve opening. The main body part is in a hollow cylinder shape and is connected with the small-diameter end of the skirt part; the connecting part comprises a connecting arm, the connecting arm is folded from the blood outflow end to the blood inflow end, and the radial inner side of the connecting arm is used for being connected with or abutting against the fishing ring; axial pre-tightening force can be formed between the fishing ring and the plugging frame through cooperation of the connecting arms and the fishing ring, and the axial pre-tightening force is used for enabling the skirt edge part to be attached to the side wall of the atrium in a sealed mode and conducting axial positioning on the fishing ring.

The invention discloses an extraction and culture method of central nervous system vascular wall cells, and relates to the technical field of cell culture. Microvascular clumps are separated through one-step enzymolysis in combination with two-time centrifugation and four-time natural settling, a large number of high-purity and high-activity vascular wall cells are obtained through in-vitro culture and five-time passage, and the method has the advantages of being easy and convenient to operate, low in cost, high in efficiency, good in cell activity and high in purity. The method comprises the following steps: S1, carrying out enzymatic dissociation on obtained brain and spinal cord tissues by using papain; s2, blowing and beating brain and spinal cord tissues to obtain brain and spinal cord tissue homogenate; s3, adding bovine serum albumin into the brain and spinal cord tissue homogenate, and centrifuging twice to obtain a low-purity microvascular plexus; s4, naturally settling the low-purity capillary plexus for four times to obtain a high-purity capillary plexus; s5, inoculating the high-purity capillary plexus into a culture plate; s6, performing in-vitro culture to enable the cells to climb out of the capillary plexus to obtain vascular wall cells; and S7, carrying out passage for five times to obtain the high-purity vascular wall cells.

This disclosure relates generally to electrically stimulating dilators for selectively stimulating nerves during surgical procedures. A dilator for use in surgery includes a body extending from a proximal end to a distal end, with a clip attachment area at the proximal end of the body for receiving a stimulating clip. The clip attachment area includes an anterior electrode and a posterior electrode, the anterior electrode and posterior electrode insulated from each other. The dilator also includes a first conductive pathway extending from the anterior electrode to the distal end of the body and a second conductive pathway extending from the posterior electrode to the distal end of the body. An anterior emitter is at a distal end of the first conductive pathway and a posterior emitter is at a distal end of the second conductive pathway, with the posterior emitter disposed opposite the anterior emitter.