4 results about "Plexus" patented technology

The application discloses an interpretable tongue diagnosis auxiliary diagnosis system based on knowledge graph fusion reasoning. The system obtains tongue diagnosis image data containing at least tongue surface image and sublingual plexus image, determines a plurality of preset tongue diagnosis regions and generates regional node features; constructs an image graph and updates the image graph by a first graph neural network to obtain image node features; constructs a traditional Chinese medicine knowledge graph containing tongue image, pathological factors, viscera, syndrome nodes and their relationships and updates the knowledge graph by a second graph neural network to obtain knowledge node features, projects and maps the image node features and the tongue image node features to the same embedding space, aligns the cross-modal modes according to a contrast learning loss to obtain cross-modal correlation; constructs a fusion graph based on the image graph, the knowledge graph and the cross-modal correlation and performs graph reasoning to output syndrome results and reasoning path information. Explicit connection of image regions and traditional Chinese medicine semantics and output of traceable paths reduce experience dependence and enhance interpretation and review.

The utility model belongs to the field of the vein physiotherapy technology, concretely relates to a negative pressure vein physiotherapy appearance, including physiotherapy appearance main part, the one side of physiotherapy appearance main part is connected with negative pressure pipe and is provided, the output end of negative pressure pipe is connected with the adapter of setting up, the downside of adapter is provided with tin. Negative pressure pipe steady sleeve connection in the outside of cannula one, need not often dismount, it is convenient to guarantee the stability of negative pressure pipe, when needing to replace different tins, cover sleeve connection in the outside of sealing disc, through snap ring and recess clamping, cannula two tightly inserts in the inside of sleeve, realize with the intercommunication of negative pressure pipe, through control panel start micro -vibration motor, need not specially replace vibration tin, all kinds of tins can realize vibration when needing, and only need production time, guarantee different kinds and model tin sealing disc size corresponding cover unchange, namely can quick replacement and adaptation different tins, greatly increase the convenience of replacing tin.

This disclosure relates to an oral dosage form (such as a capsule) comprising (a) mildametinib having a d90 of 250 microns or less, a d50 of 50 microns or less, or both, and (b) one or more pharmaceutically acceptable pharmaceutical excipients. Such dosage forms are useful in the treatment of tumors and cancers (such as plexus neurofibroma (PN), plexus neurofibroma associated with neurofibromatosis type 1 (NF1-PN), high-grade glioma (HGG), low-grade ovarian cancer, Langerhans cell histiocytosis (LCH), brain cancer, and cancers that have metastasized to the patient's brain). This disclosure also relates to improved dosage regimens for mildametinib treatment.

The invention discloses an extraction and culture method of central nervous system vascular wall cells, and relates to the technical field of cell culture. Microvascular clumps are separated through one-step enzymolysis in combination with two-time centrifugation and four-time natural settling, a large number of high-purity and high-activity vascular wall cells are obtained through in-vitro culture and five-time passage, and the method has the advantages of being easy and convenient to operate, low in cost, high in efficiency, good in cell activity and high in purity. The method comprises the following steps: S1, carrying out enzymatic dissociation on obtained brain and spinal cord tissues by using papain; s2, blowing and beating brain and spinal cord tissues to obtain brain and spinal cord tissue homogenate; s3, adding bovine serum albumin into the brain and spinal cord tissue homogenate, and centrifuging twice to obtain a low-purity microvascular plexus; s4, naturally settling the low-purity capillary plexus for four times to obtain a high-purity capillary plexus; s5, inoculating the high-purity capillary plexus into a culture plate; s6, performing in-vitro culture to enable the cells to climb out of the capillary plexus to obtain vascular wall cells; and S7, carrying out passage for five times to obtain the high-purity vascular wall cells.