55 results about "Proctitis" patented technology

The invention belongs to the technical field of medicaments, and provides a method for preparing total triterpene of Chinese medicament garden burnet root. The total triterpene is mainly obtained by performing reflux extraction by 70 percent ethanol, absorbing by a macroporous absorbent resin, using water to wash off impurities, using ethanol solution for elution, then decolorizing an eluent by daiamid powder, using the ethanol solution for elution, and recovering the ethanol through pressure reduction. The total triterpene mainly contains triterpenic acid active components such as arjunic acid, 1beta-euscaphic acid, euscaphic acid, tormentic acid and the like, and triterpenoid saponin active components such as sanguisorbin I, sanguisorbin II, sanguisorbin III, niga-ichigoside, kaji-ichigoside F1 and the like. Experimental results show that the total triterpene has remarkable anti-inflammatory and analgesic effects. The total triterpene has definite action substance basis and action mechanism as well as simple preparation technology, is suitable for industrialized production, can be taken as medicinal raw materials for treating inflammatory diseases such as burn and scald, rectitis, ulcerative colitis, pyelonephritis and the like, and is prepared into clinically acceptable dosage forms such as tablets, capsules, granules or compound preparations according to the prior process.

The invention belongs to the field of biotechnology and medical technology and provides a miRNA marker related to malignant transformation of colitis and proctitis. The marker is a composition of miR-138-5p, miR-145-5p, miR-146a-5p and miR-150-5p. The invention further provides a primer of the miRNA marker, application of the miRNA marker in preparation of a rectal cancer early-diagnosis kit, and the rectal cancer early-diagnosis kit. The provided miRNA marker, including miR-138-5p, miR-145-5p, miR-146a-5p and miR-150-5p and related to malignant transformation of colitis and proctitis is used for early screening of the colon cancer and the rectal cancer and has the characteristics of easiness in operation, high specificity and high sensitivity.

The invention discloses a medicine composition for treating chronic ulcerative colitis. The medicine composition comprises, by weight, 90-150 parts of humifuse euphorbia herb, 10-60 parts of lucid ganoderma, 60-120 parts of garden burnet, 50-150 parts of folium callicarpae pedunculatae, 20-100 parts of radix sophorae flavescentis, 20-80 parts of hairyvein agrimony, 50-110 parts of madder, 10-70 parts of Poria cocos, 10-70 parts of Semen Euryales, 10-80 parts of Cacumen biotae, 10-80 parts of pagoda tree flowers, 10-70 parts of cuttlebone, 5-40 parts of gallnut, 10-70 parts of rhizoma bletillae, 0-40 parts of Acacia catechu and 0-40 parts of pseudo-ginseng. A preparation process of the medicine composition comprises the steps of weighing out all pharmacodynamic raw materials according to a formula and uniformly mixing all pharmacodynamic raw materials through crushing, water extraction concentration, alcohol extraction concentration or a method combining the crushing, the water extraction concentration and the alcohol extraction concentration, so that the medicine composition can be obtained. The medicine composition is prepared with Chinese herbal medicines serving as raw materials, can relieve internal heat, promote tissue regeneration and support healthy energy, is particularly applicable to treatment of ulcerative colitis, Crohn's diseases, chronic colitis, radioactive colitis and proctitis, irritable bowel syndrome and the like and can solve the problems that antibiotics are taken for a long term, beneficial bacterium drugs are not ideal in effect and toxic and side effects are large.

The invention relates to a traditional Chinese medicinal preparation for treating chronic enteritis, colitis and proctitis, which is prepared from Chinese pulsatilla root, purslane, corktree bark, root of red rooted saliva, and black catechu by the weight ratio through the traditional preparing process.

The invention discloses an enema for treating proctitis. The enema comprises, by weight, 3-9 parts of nutgall, 15-30 parts of chufa, 10-30 parts of honeysuckle, 3-9 parts of gynura segetum, 3-10 parts of sisal hemp, 15-30 parts of ossa draconis, 15-30 parts of indigo naturalis, 10-20 parts of circium japonicum, 10-20 parts of sea-buckthorn, 5-9 parts of houttuynia cordata, 3-6 parts of acacia catechu, 3-15 parts of rhizoma atractylodis, 15-40 parts of oriental arborvitae, 10-30 parts of fructus aurantii and 10-30 parts of astragalus membranaceus. The enema has the advantages of clearing away heat and toxic materials, invigorating spleen to remove dampness, removing stasis to dredge collaterals and inducing astringency. Dialectical treatment is carried out according to different patterns of syndrome in clinic. The enema is suitable for treating acute and chronic proctitis patients.

The invention provides a Chinese medicine composition capable of curing proctitis. The Chinese medicine composition capable of curing the proctitis is characterized by being prepared by the mixing of the following components by weight: 10 to 20 parts of liquorice, 15 to 25 parts of radix paeoniae alba, 10 to 20 of parts myrrh, 15 to 25 parts of plantain herb, 5 to 15 parts of kudzu vine roots, 10 to 20 parts of garden burnet, 5 to 15 parts of ophiopogon roots, 15 to 25 parts of honeysuckle, 5 to 15 parts of herba epimedii, 15 to 25 parts of smoked plum, 5 to 15 parts of salt, 10 to 20 parts of fried gorgon euryale seeds, 10 to 20 parts of rhizomacyperi, 15 to 25 parts of agrimonia pilosa, 20 to 30 parts of codonopsis pilosula and 5 to 15 parts of forged keel. The Chinese medicine composition capable of curing the proctitis has the advantages that the components are reasonable, medicine cooperate with each other and are complementary to each other, the absorbing effect is good, the curing effect is remarkable, and the effect of curing the proctitis is achieved. The Chinese medicine composition capable of properly curing the proctitis is a pure Chinese medicine composition, and is free from drug-fast, low in cost and wide in material.

Health food for improving intestinal function, and a making method and application thereof belong to the technical field of health food processing. The health food for improving intestinal function is characterized by comprising 21-35% of rhizoma gastrodiae, 14-23% of semen euryales, 16-25% of rhizoma curculiginis, 6-15% of rhizoma dioscoreae, 5-12% of licorice root and 10-21% of ash bark. The heath food is made of purely natural traditional Chinese medicines as active ingredients, has the effects of enhancing immunity, diminishing inflammation, relieving pain, tonifying spleen, clearing damp and the like, is capable of effectively inhibiting excessive multiplication of intestinal harmful bacteria and regulating intestinal flora, and has special effects on acute enteritis, chronic enteritis, colonitis, proctitis, abdominal distension and diarrhea. The making method of the health food is simple, equipment investment cost is low, material sources are guaranteed, energy consumption reduced, storage and application of the health food are safe, and the health food is low in production cost, natural and environment-friendly and has no toxic and side effects.

The invention discloses thermosensitive gel containing matrine alkaloid. The thermosensitive gel containing the matrine alkaloid is prepared from the following raw and supplemental materials in percentage by mass: 1% to 5% of the matrine alkaloid, 15% to 25% of poloxamer 407, 0.1% to 1.5% of a biological adhesion agent, and 0% to 2% of a gel temperature regulator, wherein the biological adhesion agent is selected from one or a mixture of two or more of methyl cellulose, sodium carboxymethyl cellulose and sodium alginate. The thermosensitive gel disclosed by the invention is reasonable in preparation formula and gelatinized when being close to the body temperature, and has no leakage after being administrated, convenient use, and further wide clinical application prospects in aspects of preventing and/or treating colitis, vaginitis, prostatitis and a pelvic inflammatory disease and the like.

The invention relates to a traditional Chinese medicine formula for treating chronic proctitis. Proctitis is caused by careless diets, such as excessive drinking and overeating of strong excitant food, inappropriate long-term taking of weight losing medicament, excessive corrosive medicament in anus and bacteria infection. A light patient only has mucosa inflammation, and a severe patient has inflammations involving submucosa, muscular layer even rectum surrounding tissues; sometimes, part of the rectum mucosa is inflammatory, and sometimes the whole rectum mucosa or even colon mucosa are inflammatory. Proctitis is always seen in weak physique and resistance and after diseases of heart, lung, liver and gastrointestinal tract, respiratory tract infection, infectious disease; and constipation, diarrhoea, hemorrhoid, anorectal prolapse, anal fistula, polyposis, anorectal stenosis, rectum tumour, rectum damage and foreign matter all can cause proctitis. Severe patients need to be treated immediately. Prior proctitis treatment method is no more than a final operation, which causes huge pains in patient body and energy.

The invention provides traditional Chinese medicinal enteric-coated tablets for treating proctitis, colitis and irritable bowel syndrome, as well as a preparation method and application thereof. Active components for preparing the traditional Chinese medicinal enteric-coated tablets comprise the following traditional Chinese medicinal raw materials in parts by weight: 200-800 parts of smoked plum, 50-400 parts of golden thread, 50-400 parts of dried ginger, 50-400 parts of costustoot, 50-300 parts of pericarpium papaveris, and 50-300 parts of rhizoma corydalis. Clinical researches on ulcerative colitis prove that, the traditional Chinese medicinal enteric-coated tablets have a cure rate of 59.1 percent in a treatment group, and a total effective rate of 98.1 percent. Clinical researches on irritable bowel syndrome prove that traditional Chinese medicinal enteric-coated tablets have a complete remission rate of 67.8 percent in the treatment group, and a total effective rate of 95.2 percent. In clinical researches on proctitis, the traditional Chinese medicinal enteric-coated tablets are used for treating 36 cases, wherein 32 cases are cured, 3 cases are improved, 1 case is invalid, and the total effective rate is 88.8 percent. The researches prove that the enteric-coated tablets have remarkable advantages and improvement in treatment after the preparation and dose forms are improved, and are advantageous to clinical application. The traditional Chinese medicinal enteric-coated tablets are easily available in raw materials, simple in method and pollution free, is suitable for industrial production, and has higher application value.

The invention discloses a traditional Chinese medicine composition for treating colitis and proctitis and application thereof. The traditional Chinese medicine composition is prepared from the following medicinal raw materials in parts by weight: 10-15 parts of radix codonopsitis, 10-15 parts of Chinese yams, 10-15 parts of stir-fried largehead atractylodes rhizome, 10-15 parts of tuckahoe, 24-30parts of coix seeds, 4-8 parts of radix bupleuri, 10-15 parts of radix sileris, 10-15 parts of white peony roots, 4-8 parts of dried tangerine peel, 10-12 parts of Chinese pulsatilla roots, 10-15 parts of herba patriniae, 10-15 parts of wild grape vines, 10-15 parts of humifuse euphorbia herb, 10-15 parts of pomegranate peel, 10-15 parts of roasted medicine terminalia fruits, 10-15 parts of cortexfraxini and 3-6 parts of honey-fried licorice roots. The traditional Chinese medicine composition disclosed by the invention has the effects of purging intense heat, benefiting the spleen, and stopping painful diarrhea, and is more effective in treating colitis and proctitis.

The invention discloses an olive bitter glycoside suppository. Medicine components of the suppository are bitter glycosides, components and proportions of substrates of the suppository are adjusted, and quick release suppositories and suppositories with medium release rate can be obtained. The suppository is supplied through a vagina and can be used for treating gynecological diseases such as vaginitis, pelvic infection and cervical erosion, the suppository is supplied through a rectum can be used for treating rectitis and rectal cancer, and the suppository can enter general blood circulation through a rectal mucosal lower vessel and has the functions of generalized inflammation resistance and osteoporosis improvement and the like.

The present invention is related to a use for treating and preventing inflammation related disorder of a composition containing a drug and hyaluronic acid (HA) or HA mixture, whereas the HA or the HA mixture as a delivery vehicle can be a formulation including at least two HAs having different average molecular weights. The composition has been demonstrated to be capable of reducing the therapeutic dose of a drug on the treatment and prevention of inflammation related disorders is acute inflammatory disease, chronic obstructed pulmonary disease, coeliac disease, conjunctivitis, otitis, allergic rhinitis, gingivitis, aphthous ulcer, bronchitis, gastroesophageal reflux disease (GERD), esophagitis, gastritis, enteritis, peptic ulcer, inflammatory bowel disease (IBD), Crohn's Disease, irritable bowel syndrome (IBS), intestinal inflammation or allergy, urethritis, cystitis, vaginitis, proctitis, eosinophilic gastroenteritis, or rheumatoid arthritis.

The invention discloses a traditional Chinese medicine composition for treating proctitis. The traditional Chinese medicine composition is prepared from the following main raw materials in parts by weight: 8 to 11 parts of radix paeoniae alba, 3 to 8 parts of ephedra (added later), 9 to 21 parts of poria cocos, 8 to 14 parts of selfheal, 13 to 15 parts of divaricate saposhnikovia root, 11 to 15 parts of szechwan chinaberry fruit, 9 to 16 parts of auricled hedyotis herb, 4 to 10 parts of myrobalan, 12 to 20 parts of hypericum japonicum, 10 to 16 parts of angelica sinensis, 14 to 19 parts of pseudo-ginseng, 6 to 14 parts of dracocephalum heterophyllum benth, 4 to 8 parts of concha haliotidis, 5 to 8 parts of streptocaulon griffithii hook, and 9 to 17 parts of schisandra chinensis. The traditional Chinese medicine composition is a pure traditional Chinese medicine preparation and free of obvious toxic and side effects; the composition achieves selection of treatment based on the differential diagnosis according to the principle of traditional Chinese medicine; the traditional Chinese medicine composition has a plurality of functions such as clearing away heat and relieving exterior syndrome, relieving swelling and pain, and clearing dampness and promoting diuresis; and the clinic application shows that the product is obvious in treatment effect, safe and reliable.

A method for treatment of proctitis is disclosed in which a therapeutic composition is introduced into the rectum to contact a mucosal surface within the rectum. The pharmaceutical composition comprises a reverse-thermal gelation polyoxyalkylene block copolymer, a pharmaceutical substance and a pharmaceutical substance selected from the group consisting of glutathione and a precursor for glutathione biosynthesis.

The invention relates to an anorectal health care physiotherapy instrument, belonging to a health care physiotherapy product; the anorectal health care physiotherapy instrument comprises an anal plug (1) and a controller (2), wherein the anal plug (1) comprises a baffle (1-1), a fixed end (1-2) connected with the baffle (1-1), and a vibration end (1-4) connected with the fixed end (1-2) by an eccentric motor (1-3); the eccentric motor (1-3) is fixedly connected with the fixed end (1-2); the vibration end (1-4) is driven by the eccentric motor (1-3) to vibrate by taking the center axle of the anal plug (1) as equilibrium position; and the controller (2) comprises a processor (2-1) which is connected with the eccentric motor (1-3) by a lead. The anorectal health care physiotherapy instrument is safe and reliable in anorectal physiotherapy, and has the functions of anal dilatation, hemostasis, inflammation prevention, detumescence, analgesia, vegetative nerve adjustment and the like, thus being suitable for symptoms such as straining, astriction, difficult defecation, pain and the like which are caused by internal hemorrhoids, proctitis and anal sinusitis.

Compositions comprising melatonin or derivatives thereof are provided for topical administration to the vaginal and/or rectal epithelium to protect against vaginal and/or rectal radiation injury due to radiotherapy.

The invention discloses application of a Geum japonicum Thunb extract in preparing a medicine for preventing and treating autoimmune diseases, and belongs to the technical field of medicines. A preparation method of the Geum japonicum Thunb extract comprises the following steps: soaking and extracting Geum japonicum Thunb in first alcohol, adding water, and continuing soaking and extracting to obtain an alcohol extracting solution; carrying out vacuum concentration treatment on the alcohol extracting solution, and then carrying out spray drying treatment to obtain solid powder; dissolving thesolid powder in water, extracting by using ethyl acetate, removing an ethyl acetate extracting solution, and extracting by using second alcohol to obtain an alcohol extracting solution; and carrying out reduced pressure drying treatment on the alcohol extracting solution, and then sequentially carrying out freeze drying treatment and grinding treatment to obtain the Geum japonicum Thunb. The Geumjaponicum Thunb extract has remarkable prevention and treatment effects on autoimmune diseases such as ulcerative colitis, regional enteritis, proctitis, bacillary dysentery, enteritis, gastric ulcer,rheumatoid arthritis and the like.

The invention relates to a medicinal agent to treat hemorrhoid, proctitis and other inflammatory proctology diseases. Said medicinal agent represents a suppository with a mass of 1.35 to 3.65 g and comprises, as active ingredients, 0.3 to 0.65 g of diosmin, 0.05 to 0.2 g of dexpanthenol, 0.05 to 0.2 g of green tea extract, and, as auxiliary substances, 0.0135 to 0.1825 g of emulsifier and fatty acid glycerides. The medicinal agent of the present invention provides for a combined antimicrobial, local anesthetic, anti-inflammatory, wound-healing and adaptogenic therapeutic effect.

The invention relates to Shuanghuang Changningye, comprising the following components: a radix sophorae flavescentis, Chinese gall, cortex phellodendri, radix isatidis, rhizoma coptidis and folium isatidis. The Shuanghuang Changningye is capable of clearing heat and drying dampness, and cooling blood and detoxifying. The Shuanghuang Changningye is used for treating chronic colorectal inflammatory diarrhea (chronic colitis, proctitis and ulcerative colitis) and anal sinusitis through rectal administration.