Drug sustained-release material and application thereof in sustained-release material for treating proctitis

A technology for slow-release materials and drugs, which can be used in plant raw materials, drug combinations, drug delivery, etc., and can solve problems such as high patient compliance requirements.

Active Publication Date: 2020-02-25
CHINA THREE GORGES UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, enema treatment will bring a lot of pain to the patient, and the medicine is not easy to stay in the lesion for a long time, which requires a high degree of cooperation from the patient.

Method used

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  • Drug sustained-release material and application thereof in sustained-release material for treating proctitis
  • Drug sustained-release material and application thereof in sustained-release material for treating proctitis
  • Drug sustained-release material and application thereof in sustained-release material for treating proctitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] (1) Hydrogel layer preparation:

[0044] React polyethylene glycol (molecular weight 2000, the same below) with IPDI at a molar ratio of 1:2 to obtain NCO-capped polyethylene glycol (PEG-2NCO). Take 100 g of PEG-2NCO and dissolve it in an appropriate amount of water at 40°C. Add 1.5 g of 2'-deoxyadenosine-5'-monophosphate, 20 g of sodium chloride, 10 g of PVA (degree of polymerization 1700, degree of hydrolysis 99%), and 1.5 g of vitamin C, and set aside.

[0045] (2) Preparation of the drug-loaded layer: 38.8 g of ε-caprolactone, 1.80 g of 1,4-butanediol, and 0.08 g of dibutyltin dilaurate. Put ε-caprolactone into the reaction flask, dissolve 1,4-butanediol in 10ml of DMF, add it to the reaction flask, vacuumize for 30min, and pass nitrogen to make ring-opening polymerization under nitrogen environment; 140 Stir the reaction for 4 hours at ℃, and stir for 3 hours under vacuum at 180℃; put it into a vacuum drying oven to evaporate the solvent.

[0046] Weigh 10 g of t...

Embodiment 2

[0055] The preparation of the hydrogel layer and the hydrophobic layer is the same as in Example 1.

[0056] Preparation of the drug-loaded layer: (1) Weigh 10 g of PCL (number average molecular weight 2000) and dissolve it in 10 g of DMF by heating, and vacuumize at 100° C. for 30 min. (2) After cooling to 40°C, add 2.2g of IPDI to react for 2 hours, raise the temperature to 80°C and react for 2 hours, then cool to room temperature. (3) 1.2g of paclitaxel and 1.2g of 5-aminosalicylic acid were dissolved in 1g of DMF and added therein, stirred evenly, and set aside.

[0057] The assembly of the drug-carrier composite membrane is similar to Example 1.

Embodiment 3

[0059] Preparation of the hydrogel layer:

[0060] (1) Copolymerize vinyl acetate and acrylic acid at a molar ratio of 10:1: dissolve 30 g of vinyl acetate and acrylic acid monomers in DMF, add 0.15 g of azobisisobutyronitrile AIBN initiator to initiate polymerization, and react for 10 hours. A polyvinyl acetate-acrylic acid copolymer was obtained. (2) adding 10% NaOH solution to carry out hydrolysis reaction to obtain polyvinyl alcohol-acrylic acid copolymer. (3) Add 1.5g of tannic acid, 3.5g of deoxyadenosine acid, 10g of gelatin, 20g of NaCl, and add 100g of water to dilute, mix well, then add 5g of trifunctional aziridine crosslinking agent (SC100) and mix Evenly; add 50g of Panax notoginseng extract, Sophora japonica extract, and ginseng extract for later use.

[0061] The drug-loaded layer is the same as Example 2, and the preparation of the hydrophobic layer is the same as Example 1.

[0062] The assembly of the drug-carrier composite membrane was similar to Example ...

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Abstract

The invention provides a drug sustained-release material and an application of the drug sustained-release material for treating proctitis. An outer layer of a composition is prepared by tannic acid, 3, 4, 5-trihydroxybenzoic acid, deoxyadenylic acid modified gelatin, polyethylene glycol, polyvinyl alcohol and the like; a middle layer is a drug sustained-release layer taking poly epsilon-caprolactone and polylactic acid as chain segments, and an inner layer is condensed silica gel modified by 1H, 1H, 2H, 2H-perfluoroheptadecane trimethoxysilane and N-2-(aminoethyl)-3-aminopropyltrimethoxysilane. The drug sustained-release composition has good adhesion performance for treating pathological organs such as intracavitary mucosas such as proctitis and the like which are difficult to administrate. The rectal drug sustained-release material composition provided by the invention has good elasticity and interface bonding strength, good biocompatibility, and no toxicity or harm to human body. Thecomposition is capable of improving the interface bonding force between different layers is wide in application range and can be applied to a series of multi-layer materials to improve the interfacebonding force.

Description

technical field [0001] The invention relates to the field of interface binding and drug slow-release materials, prepares a three-layer "plaster" type drug slow-release material combination for treating proctitis, and provides a method for improving the interface bonding strength between each layer of slow-release materials. Background technique [0002] In recent years, the research on the preparation of multilayer drug sustained-release carriers has become a hot topic, and most of the drug sustained-release materials are made of biodegradable and non-toxic polymer materials with good biocompatibility to prepare drug carriers The advantages of drug administration are: (1) The drug will not be released suddenly after the drug is administered, and the appropriate drug concentration can be maintained for a long time. (2) Reduce the pain and discomfort of patients with frequent medication. (3) Placing the drug-loaded carrier at the lesion site can quickly treat the diseased cel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/337A61K31/60A61K36/258A61K36/489A61K45/06A61K47/10A61K47/32A61K47/34A61K47/42A61P1/00
CPCA61K9/0031A61K9/7092A61K31/337A61K31/60A61K36/258A61K36/489A61K45/06A61K47/10A61K47/32A61K47/34A61K47/42A61P1/00A61K2300/00
Inventor 周昌林周文燕汪磊刘杨李永双李德江鲁明骞
Owner CHINA THREE GORGES UNIV
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