5624results about "Sheet delivery" patented technology

Pharmaceutical formulations of novel indole compounds and psilocybin analogs are manufactured, provided in novel oral, transdermal, and nasal pharmaceutical compositions for use to treat neurological, mood or abuse diseases and disorders.

Pharmaceutical formulations of novel indole compounds and psilocybin analogs are manufactured, provided in novel oral, transdermal, and nasal pharmaceutical compositions for use to treat neurological, mood or abuse diseases and disorders.

Pharmaceutical formulations of novel indole compounds and psilocybin analogs are manufactured, provided in novel oral, transdermal, and nasal pharmaceutical compositions for use to treat neurological, mood or abuse diseases and disorders.

Pharmaceutical compositions for the transmucosal delivery of N-N-dimethyltryptamine (DMT) acceptable salt or prodrug thereof in combination with a monoamine oxidase inhibitor to achieve desired bioavailability suitable for the treatment of neurological disorders.

The invention relates to the technical field of transdermal drug delivery, in particular to a drug-loaded microneedle, a drug-loaded microneedle patch and an electrically controlled drug release microneedle system.The drug-loaded microneedle comprises a needle body, a drug component and an electric sealing material, the needle body has biocompatibility and conductivity and is a hydrogel microneedle or a porous microneedle, and the drug component is attached to the drug-loaded microneedle patch. The medicine components are doped in the needle body or coated on the outer surface of the needle body. The electric sealing material is doped in the needle body and / or wraps the surface of the needle body, and the electric sealing material is connected with the needle body through at least one of covalent bonds, ionic bonds and coordinate bonds. When the drug-loaded microneedle is inserted into a target tissue, controlled release of drug components can be achieved through an electrical stimulation signal, and active components are guided into the target tissue through electric drive. According to the invention, the ion exchange behavior of the material is controlled through the electric field, so that the opening and closing of a drug release channel are realized, the purpose of electric switching chemical sealing is achieved, reversible control is realized by adjusting the intensity and direction of the electric field, and the accurate opening and closing of drug release are realized.

Pharmaceutical formulations of novel indole compounds and psilocybin analogs are manufactured, provided in novel oral, transdermal, and nasal pharmaceutical compositions for use to treat neurological, mood or abuse diseases and disorders.

The invention discloses a porphyrin-based covalent organic framework nano material, a preparation method and application of the porphyrin-based covalent organic framework nano material in polyurethane, and belongs to the field of functional nano materials and antibacterial materials. The porphyrinyl covalent organic framework nano material is prepared from 5, 10, 15, 20-tetra (4-aminophenyl) porphyrin and bis-(5-formyl furfuryl) ether through a Schiff base reaction, and the structural formula of the porphyrinyl covalent organic framework nano material is # imgabs0. The porphyrinyl covalent organic framework nano material prepared by the invention has relatively high photothermal conversion efficiency when being used as a photothermal agent, and has a relatively good sterilization effect under the condition of relatively low concentration. Besides, based on the porphyrin-based covalent organic framework nano material, a WPUS / Por-COF composite film is prepared, the composite film has excellent mechanical properties and excellent photothermal conversion efficiency, and has a good sterilization effect under the condition of relatively low concentration, bacteria can be inactivated within a short time, and the sterilization rate can reach 99% or above.

The invention discloses a drug electric controlled release hydrogel patch for wound healing, and belongs to the technical field of biomedical materials, the hydrogel patch comprises sheet electrodes, conductive hydrogel, a liquid storage tank and a flexible circuit, the two sheet electrodes are respectively attached to two side surfaces of the conductive hydrogel to form a sandwich structure, and a hole is formed in the middle of one sheet electrode; the two sheet electrodes are connected to the flexible circuit through wires, and the flexible circuit controls the two sheet electrodes to generate voltage difference. The liquid storage tank is used for storing a medicine solution and comprises a liquid storage tank cavity and a liquid storage tank hole, the conductive hydrogel and the liquid storage tank cavity form a closed space through the liquid storage tank hole, one part of the conductive hydrogel is exposed outside, and the other part of the conductive hydrogel is in the liquid storage tank cavity; the conductive hydrogel is exposed outside, and the surface, attached with the sheet-shaped electrode with a hole in the middle, of the conductive hydrogel is a treatment surface facing a wound surface. The hydrogel patch can realize long-term continuous supplement of drugs in hydrogel and program-controlled drug release, and wound healing is promoted through cooperation of electrical stimulation and drug release.

Pharmaceutical formulations of novel indole compounds and psilocybin analogs are manufactured, provided in novel oral, transdermal, and nasal pharmaceutical compositions for use to treat neurological, mood or abuse diseases and disorders.

Pharmaceutical formulations of novel indole compounds and psilocybin analogs are manufactured, provided in novel oral, transdermal, and nasal pharmaceutical compositions for use to treat neurological, mood or abuse diseases and disorders.

The invention relates to the technical field of film agent products, in particular to a film agent product and an oral film product, the film agent product comprises a functional film layer and a sheet layer, the functional film layer contains an active component, and the active component is suitable for being released from the functional film layer and acting on a target position; the sheet layer comprises a first sheet layer, and the first sheet layer is arranged on at least part of the surface of the functional film layer; and / or, the first sheet layer is embedded in the functional film layer. By arranging the sheet layers, the tensile strength of the film agent product can be improved, the shape maintaining capacity of the film agent product is improved, and the problems that the film agent product is prone to shrinkage and deformation and is difficult to take out midway in the using process are effectively solved.

The invention belongs to the technical field of biomedical textile materials, and relates to a multi-level artificial dura mater repair scaffold and a preparation method thereof.The main body structure of the repair scaffold is three layers of nanofiber membranes deposited layer by layer and crosslinked through glutaraldehyde, the inner layer is a coaxial nanofiber membrane loaded with minocycline and insulin-like growth factor-1, and the outer layer is a coaxial nanofiber membrane loaded with glutaraldehyde. Wherein the insulin-like growth factor-1 is located in the core layer, and the minocycline is located in the shell layer; the middle layer is a polycaprolactone nanofiber membrane, and the outer layer is a polycaprolactone / hyaluronic acid nanofiber membrane; the inner layer can release minocycline and insulin-like growth factor-1 in a sequential manner, so that the inflammation environment after brain injury can be effectively regulated and controlled, and neural restoration can be promoted; and the outer layer shows an excellent anti-adhesion effect by inhibiting the adhesion and proliferation of fibroblasts, so that the hindrance on nerve regeneration caused by excessive formation of scar tissues is effectively avoided. The middle layer obviously enhances the ability of the stent to prevent leakage of cerebrospinal fluid; and the structural design is exquisite, the preparation method is simple and convenient, and wide market prospects and profound social values are achieved.

The invention relates to the field of nano-drug delivery preparations, in particular to a traditional Chinese medicine transdermal drug delivery preparation based on a nano-coating technology and a preparation method thereof, the traditional Chinese medicine transdermal drug delivery preparation comprises a liposome-metal organic framework composite carrier, and the composite carrier comprises traditional Chinese medicine active ingredients; a meridian point targeted transdermal enhancer; an iontophoresis device for dynamically sensing skin impedance; the invention relates to an intelligent administration time sequence control system based on a traditional Chinese medicine midnight-noon ebb-flow theory. The liposome-metal organic framework composite carrier is adopted, the similar structure of liposome and skin and the high specific surface area of MOF are fully utilized, efficient encapsulation and transdermal absorption of active ingredients of traditional Chinese medicine are achieved, and compared with a traditional transdermal patch, the drug transdermal absorption rate is increased by 3-5 times.

The invention relates to the field of medical patches, and discloses a controlled-release long-acting fever cooling patch which comprises a temperature response type material layer located on the outermost side of the fever cooling patch and used for triggering rapid release of medicine when the body temperature rises; the medicine composite layer is located on the inner side of the temperature response type material layer and used for compounding the antipyretic medicine and the traditional Chinese medicine ingredients together through a carrier, providing stable release of the medicine and enhancing the medicine effect; the invention also discloses a preparation method of the controlled-release long-acting fever cooling patch, which comprises the following steps: preparing the temperature response type material layer, dissolving the poly (N-isopropylacrylamide) or the copolymer thereof in a proper amount of solvent, coating the surface of the patch substrate with the solution, and drying to obtain the temperature response type material layer. The multi-layer composite structure is combined with the temperature and humidity response type material, so that the sustained release and long-acting antipyretic effect of the medicine are realized, the medicine release rate is automatically adjusted, the lasting and stable antipyretic effect is ensured, the medicine waste is reduced, and the convenience and comfort are improved.

The invention discloses a double-crosslinking network hydrogel film for treating oral ulcer, a preparation method and application, and relates to the technical field of biomedical materials. According to the hydrogel film, a dual-network synergistic enhancement structure is constructed through covalent / non-covalent bi-crosslinking, the adhesion to oral mucosa is remarkably enhanced by adopting dopamine (DA) modified hyaluronic acid (HA), and the mechanical property is greatly improved by utilizing a bi-crosslinking network system of disulfide bond / double bond crosslinking (chitosan and CS) and hydrogen bond / catechol self-crosslinking (hyaluronic acid and HA); the antioxidant and anti-inflammatory characteristics of lipoic acid (LA) and the natural antibacterial property of chitosan (CS) are combined to play a synergistic effect, so that the antibacterial and anti-inflammatory effects are remarkably improved. Meanwhile, multifunctional modified materials such as metacrylic acid ester are introduced, so that the functionality and the application range of the hydrogel film are expanded. The preparation technology is optimized, it is ensured that the material is safe and effective, large-scale production is easy, and an efficient and reliable novel material is provided for oral ulcer treatment.

The invention discloses recombinant I-type collagen with a low-temperature self-assembly characteristic as well as a preparation method and application thereof, and relates to the technical field of genetic engineering. The recombinant I-type collagen with the low-temperature self-assembly characteristic is characterized in that an amino acid sequence of the recombinant I-type collagen is obtained by taking a human I-type collagen fragment as a basic unit and repeatedly connecting in series for n times, an amino acid sequence of the human I-type collagen fragment is shown as Seq ID NO.1, and n is an integer greater than or equal to 1. According to the invention, nucleotides of repetitive fragments of functional areas of the human-derived I-type collagen are optimized and screened, and co-expressed with hydroxyproline enzyme genes in a pichia pastoris system, so that the recombinant I-type collagen with low-temperature self-assembly characteristics is successfully obtained.

Provided are: a high-quality microneedle preparation containing collagen as a main component; and a method for producing the microneedle preparation. A microneedle preparation containing collagen and one or more pH regulators as essential components; a microneedle preparation which further contains, as an essential component, one or more types of carboxyl group-containing water-soluble polymers; also provided is a method for producing a microneedle preparation, which comprises: a step for preparing an aqueous solution at 37 DEG C or less from a raw material that contains collagen and one or more pH regulators and, if necessary, one or more carboxyl group-containing water-soluble polymers, and preparing a microneedle raw material solution in which the content of collagen in the aqueous solution is 5 mass% or less; and a step for filling a mold with the microneedle starting material liquid and drying the microneedle starting material liquid.

Provided is a medical adhesive agent. The adhesive agent comprises: a water-dispersible copolymer produced by the copolymerization of a monomer mixture comprising a (meth)acrylic acid alkyl ester, a carboxy-group-containing monomer, a nitrogen-atom-containing monomer, and a silane-based monomer; and an organic liquid component in which the number of hydroxyl groups per molecule is more than 1.

The invention relates to a wound repair spray, and relates to the field of medical wound repair. The wound repair spray comprises a humectant, ethylhexylglycerin, recombinant collagen, a preservative, a pH buffer agent, water and sodium hyaluronate with the molecular weight of 2000 Da to 10000 Da, and the prepared wound repair spray is fine and soft in atomization effect, uniform and dispersed in spray, moderate in force, suitable for being immediately used after an operation and on sensitive skin, free of toxic and side effects and free of side effects. A good wet healing environment can be provided for wound repair, the healing time of the wound is shortened, and the repair performance is improved.

The invention discloses a double-layer gel patch for diabetic wounds and a preparation method of the double-layer gel patch. The double-layer gel patch is composed of an upper gel layer and a lower gel layer, and when the double-layer gel patch is used, the lower gel layer is attached to the surface of skin; the upper gel layer is prepared from methacrylated gelatin, oxidized hyaluronic acid, a photoinitiator and an anti-inflammatory drug, and the lower gel layer is prepared from 3-carboxyphenylboronic acid grafted gelatin, dihydrocaffeic acid grafted epsilon-polylysine and an antibacterial agent. The double-layer gel disclosed by the invention has high mechanical strength and absorbability, and meanwhile, a sequential treatment strategy of firstly resisting bacteria and then resisting inflammation can be realized.

The invention belongs to the technical field of medical and mechanical combinations, and discloses a high-permeability and low-sensitivity ripdicaine wound patch and a preparation method thereof.The high-permeability and low-sensitivity ripdicaine wound patch comprises a wound patch body, and the wound patch body is prepared from, by mass, 0.1%-0.4% of sodium hyaluronate, 1.5%-3.5% of lidocaine, 1.5%-3.5% of prilocaine, 3%-10% of solvent, 0.5%-8% of emulsifier, 2%-10% of humectant, 0.1%-5% of soothing agent, 0.1%-1.5% of stabilizer, 0.1%-1% of thickener and the balance water. According to the present invention, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, and the total amount of the raw materials is 100%. And the anesthetic has the advantages of quick effect taking, low sensitivity, capability of resisting moist heat sterilization and good stability.

The present disclosure relates generally to antimicrobial gels. In particular, the present disclosure relates to an antimicrobial gel comprising a eutectic solvent and a gelling agent which can be used as a drug delivery vehicle for antimicrobial agents, including for the topical delivery of antimicrobial agents to the skin of a subject. The present disclosure also relates to processes for preparing the antimicrobial gel, and to methods, uses and compositions comprising the antimicrobial gel.

A composition has a polyanionic component comprising casein or derivatives thereof, and a polycationic component, which includes chitosan or derivatives thereof. The composition is in the form of nanofibers having a diameter in a range of 20-200 nm. Also disclosed is a process for preparing the composition and a hemostatic article with the composition. A method for inhibiting loss of blood from a hemorrhaging site involves use of the composition and the hemostatic article.

The invention relates to a medicine, a medicine composition and application of the medicine and the medicine composition in treatment of liver fibrosis. The medicine and the medicine composition comprise an umbilical cord mesenchymal stem cell membrane; the umbilical cord mesenchymal stem cell membrane is prepared by the following steps: coating the surface of a temperature-sensitive culture dish with a matrix; adding the cell suspension of the umbilical cord mesenchymal stem cells into a temperature-sensitive culture dish for culturing; the temperature is reduced, the umbilical cord mesenchymal stem cells and the extracellular matrix secreted by the umbilical cord mesenchymal stem cells are separated in a lamellar mode, and the umbilical cord mesenchymal stem cell membrane is obtained. The medicine and the medicine composition provided by the invention can effectively relieve liver fibrosis.

The invention provides a traditional Chinese medicine gel patch for treating gouty arthritis and a preparation method thereof. The traditional Chinese medicine gel patch for treating gouty arthritis comprises at least a gel layer loaded with traditional Chinese medicine extracts; the traditional Chinese medicine extracts comprise the following raw materials: coix seed, phellodendron amurense, clematis root, radix scutellariae, atractylodes lancea, radix ophiopogonis, radix scutellariae, acer scutellariae, radix scutellariae, radix aconiti kusnezoffii, radix strychnii, frankincense, myrrh, angelica sinensis, safflower, cyathula root, radix paeoniae rubra, radix smilacis gracile, radix striatae, eucalyptus glomeratae, sophora flavescens, andrographis paniculatae, radix lobeliae, rhizoma coptidis, radix scutellariae, cassia twig, zanthoxylum bungeanum, and borneol; and a matrix of the gel layer comprises the following raw materials in parts by weight: silk fibroin, polyvinyl pyrrolidone, azido-polyethylene glycol-carboxylic acid, 1-ethynylcyclopropylcarboxylic acid, 2,5-dicarboxylic acid-3,4-ethylenedioxythiophene, and glycerol. The traditional Chinese medicine gel plaster of the present invention can achieve good therapeutic effects through percutaneous absorption.

A transdermal drug delivery device includes a reservoir, a transdermal membrane, a piston, a control rod, a spring, and a rotational cam. The reservoir is configured to hold a formulation. The transdermal membrane is configured to allow the formulation from the reservoir to pass therethrough. The piston is configured to move into the reservoir. The control rod is attached to the piston and includes a plurality of teeth thereon. The spring is configured to apply force to the control rod in the direction of the reservoir. The rotational cam has a first camming surface and a second camming surface that are configured to engage with the plurality of teeth. The rotational cam, when rotated, is configured to disengage the first camming surface from a first tooth of the plurality of teeth, thereby allowing the spring to advance the piston into the reservoir to expel the formulation onto the transdermal membrane.

The invention discloses a hydrogel-acellular matrix composite patch containing functionalized extracellular vesicles and a preparation method of the hydrogel-acellular matrix composite patch. The composite patch comprises a hydrogel layer and an acellular pericardium matrix material layer, and an extracellular vesicle-macrophage membrane fusion body (EV-MM) is entrapped in the cross-linked hydrogel. From two aspects of improving the targeting of EVs to the cardiac infarction part and enhancing the retention of the EVs at the cardiac infarction part, the distribution condition of the EVs at the cardiac infarction part is improved, so that the action efficiency of the EVs is improved, and the treatment effect is improved.

The invention discloses a multi-drug truncation microneedle, a preparation method and application of the multi-drug truncation microneedle in promoting diabetic wounds, and belongs to the technical field of drugs. Comprising a backing (1) and an array composed of a plurality of multi-drug cutting needles (2) on the backing, each multi-drug cutting needle is of a microneedle structure and comprises a gel slow-release needle tip (21) and a water-soluble instant needle body (22), the gel slow-release needle tip (21) and the water-soluble instant needle body (22) form a complete microneedle, and the water-soluble instant needle body (22) and the backing (1) are fixedly connected into a whole. The space-time delivery of the angiogenesis promoting medicine and the angiogenesis maturing promoting medicine is realized, and the angiogenesis and angiogenesis maturing processes in the chronic wound of diabetes mellitus can be accurately regulated and controlled.

The invention discloses a nano-film for relieving bone fracture pain and a preparation method thereof, and relates to the technical field of medical films, the nano-film comprises an inner layer, a middle layer and an outer layer, the three layers are prepared by mixing traditional Chinese medicine extracts and base materials, the nano-film is prepared through an electrostatic spinning technology, the components of all the layers are the same, but the proportions are different, and the inner layer and the middle layer are different. Wherein a polycaprolactone and polyvinyl alcohol blending system is selected as the base material; the inner layer has high drug-loading capacity to quickly relieve symptoms, the middle layer has continuous release, the outer layer has low drug-loading capacity to reduce initial stimulation and increase stability, the use frequency is reduced, the drug effect is prolonged, and adverse reactions are reduced; the functions of protection, slow release and quick release are realized only by adjusting the proportion of PCL / PVA, and the production process is simplified.

The invention discloses a compound traditional Chinese medicine patch for conditioning hyperplasia of mammary glands and a preparation method thereof, and relates to the technical field of traditional Chinese medicine preparations. The compound traditional Chinese medicine patch for conditioning hyperplasia of mammary glands is prepared from an iron-based metal organic framework composite drug carrying system, dopamine hydrochloride, a blank gel matrix, ethyl oleate, menthol, a solubilizer, a wetting agent and water, the iron-based metal organic framework composite drug loading system is composed of traditional Chinese medicine dihydric alcohol plastid, iron-based metal organic framework nanoparticles and cinnamomum camphora essential oil. The traditional Chinese medicine dihydric alcohol plastid and the cinnamomum camphora essential oil are loaded in the iron-based metal organic framework nano particles, so that the transdermal absorption of the medicine is improved, the pH response release property is realized, the dosage of active ingredients permeating into a focus part and the lasting action time are effectively increased, and then a coating layer is formed by polydopamine, so that the anti-inflammatory effect is improved. The dispersibility and compatibility of the drug loading system in vivo are further enhanced, the drug effect can be fully exerted, and the treatment effect on the hyperplasia of mammary glands is remarkably improved.