2217results about "Sheet delivery" patented technology

Pharmaceutical formulations of novel indole compounds and psilocybin analogs are manufactured, provided in novel oral, transdermal, and nasal pharmaceutical compositions for use to treat neurological, mood or abuse diseases and disorders.

Pharmaceutical formulations of novel indole compounds and psilocybin analogs are manufactured, provided in novel oral, transdermal, and nasal pharmaceutical compositions for use to treat neurological, mood or abuse diseases and disorders.

The invention belongs to the technical field of medical and mechanical combinations, and discloses a high-permeability and low-sensitivity ripdicaine wound patch and a preparation method thereof.The high-permeability and low-sensitivity ripdicaine wound patch comprises a wound patch body, and the wound patch body is prepared from, by mass, 0.1%-0.4% of sodium hyaluronate, 1.5%-3.5% of lidocaine, 1.5%-3.5% of prilocaine, 3%-10% of solvent, 0.5%-8% of emulsifier, 2%-10% of humectant, 0.1%-5% of soothing agent, 0.1%-1.5% of stabilizer, 0.1%-1% of thickener and the balance water. According to the present invention, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, the total amount of the raw materials is 100%, and the total amount of the raw materials is 100%. And the anesthetic has the advantages of quick effect taking, low sensitivity, capability of resisting moist heat sterilization and good stability.

The present disclosure relates generally to antimicrobial gels. In particular, the present disclosure relates to an antimicrobial gel comprising a eutectic solvent and a gelling agent which can be used as a drug delivery vehicle for antimicrobial agents, including for the topical delivery of antimicrobial agents to the skin of a subject. The present disclosure also relates to processes for preparing the antimicrobial gel, and to methods, uses and compositions comprising the antimicrobial gel.

The invention discloses a hydrogel-acellular matrix composite patch containing functionalized extracellular vesicles and a preparation method of the hydrogel-acellular matrix composite patch. The composite patch comprises a hydrogel layer and an acellular pericardium matrix material layer, and an extracellular vesicle-macrophage membrane fusion body (EV-MM) is entrapped in the cross-linked hydrogel. From two aspects of improving the targeting of EVs to the cardiac infarction part and enhancing the retention of the EVs at the cardiac infarction part, the distribution condition of the EVs at the cardiac infarction part is improved, so that the action efficiency of the EVs is improved, and the treatment effect is improved.

The invention relates to the technical field of pharmaceutical preparations, and provides a minoxidil film coating agent as well as a preparation method and application thereof. The minoxidil film coating agent provided by the invention comprises 40-60% of propylene glycol, 3-7% of polyvinyl alcohol, 20-30% of ethanol, 1-7% of minoxidil and the balance of water. According to the invention, propylene glycol is taken as a solvent, a plasticizer and a transdermal absorption enhancer, polyvinyl alcohol is taken as a film-forming material, and ethanol is taken as a volatile agent, after administration, ethanol is volatilized to promote film formation of polyvinyl alcohol, and propylene glycol enhances the plasticity of the formed film, so that the effect of reducing liquid medicine loss is achieved, the local medicine concentration is increased, and the bioavailability is improved. The minoxidil liniment disclosed by the invention has excellent skin permeability, can effectively convey a medicine to a required part, and can ensure that the medicine is released at a fixed position of the skin and is accurately administered in a medicine release process, so that the stimulation of liquid medicine flow to other parts is reduced, and a good treatment effect is achieved.

The invention relates to the technical field of plant essential oil products, and discloses a refreshing composition based on plant essential oil and a preparation method thereof.The method comprises the steps that an essential oil composition containing menthol, borneol, lime oil, patchouli oil, lavender oil, basil, pelargonium graveolens oil, clove oil and eucalyptus globulus leaf oil is prepared; constructing an ionic gel slow-release base layer; forming a plant source emulsifier composite two-phase system; and adding a light protection and anti-oxidation protection layer. According to the invention, the stability of the essential oil composition in an environment with change of illumination, temperature and humidity is remarkably improved, precise controlled release of essential oil components is realized, and the technical problems that a traditional essential oil product is easy to volatilize and poor in stability and different hydrophilic essential oil components are difficult to effectively load and release at the same time are solved.

Solid lipid nanoparticles (SLNs) for delivery of bioactive compounds are disclosed. The SLNs comprise a lipid matrix and surfactant layer encapsulating at least one bioactive compound selected from vitamins, minerals, enzymes, algae-derived bioactives, proteins, peptides, amino acids, antioxidants, small synthetic molecules, plant-derived volatile compounds, or botanical extracts. The SLNs exhibit submicron particle size, low polydispersity, and sufficient surface charge to ensure colloidal stability and efficient delivery. In one embodiment, algae-based bioactives, such as phycocyanin or fucoxanthin, are encapsulated using only natural and sustainable lipids and surfactants to improve bioavailability and support environmentally friendly formulations. The SLNs may be formulated for oral, topical, transdermal, injectable, ophthalmic, mucosal, textile, veterinary, or agricultural administration. Applications include human and animal health, functional foods, skincare, nutrient supplementation, and crop treatment. The disclosed SLNs offer a biocompatible and scalable delivery system that protects sensitive compounds, enables sustained release, and enhances absorption across diverse industries.

Novel compositions and systems for closure of wounds with antimicrobial effectiveness provide devices of improved flexibility and elasticity and are readily applied to wound sites or over wound closure devices. A novel platinum catalyst comprising platinum tetramethyldivinyl disiloxane diethyl maleate complex for use in such compositions provides for rapid curing on topical surfaces such as skin and bonds to such surfaces in about 2-5 minutes.

The invention relates to the technical field of biological medicine, in particular to a composition based on dendrobium nobile, a preparation method of the composition and application of the composition to preparation of soft capsules, buccal tablets and oral soluble film preparations, the composition takes dendrobium nobile extract as a main active ingredient, and can be matched with auxiliary materials such as excipients, disintegrating agents and film-forming agents to be optimized into different dosage forms. The soft capsule has a slow release effect, the buccal tablet is convenient to carry and take, and the oral soluble film can realize rapid oral mucosa absorption. The preparation method disclosed by the invention is stable in process and suitable for industrial production, and the obtained preparation has good bioavailability and stability, can be widely applied to the field of health-care foods or medicines, and is particularly suitable for enhancing immunity, resisting oxidation, moistening lung, promoting salivation and the like.

The invention belongs to the technical field of drug delivery systems, and discloses a two-dimensional vermiculite-based drug delivery system and a preparation method and application thereof. The preparation method comprises the following steps: carrying out ion exchange on expanded vermiculite, NaCl and LiCl, stripping by using a mechanical stripping sheet, centrifuging to obtain a two-dimensional vermiculite nanosheet dispersion liquid, dispersing a drug in the two-dimensional vermiculite nanosheet dispersion liquid, and forming a film to obtain the two-dimensional vermiculite-based drug delivery unit. The drug is synergistically loaded between layers and on the surface of the vermiculite; rich hydroxyl groups and interlayer cations on the end surface of the vermiculite interact with the drug, so that the drug release time is relatively long; the vermiculite-based drug delivery system can realize gradient order release of drugs according to a sequence from the surface to the interlayer through pH response of an affected part. Meanwhile, the vermiculite-based drug delivery system provides an antibacterial effect through enzyme-like catalytic activity, and avoids the problems of abuse of antibiotics and drug resistance.

The present invention relates to a self-adhesive layer structure for a medical patch having a hexagonal shape comprising at least one hexagon, a medical patch and a medical patch sheet comprising one or more such self-adhesive layer structures, as well as such medical patches for use in methods of treatment and a method of manufacturing such medical patches.

The invention discloses a collateral-dredging and pain-relieving gel plaster and a preparation method thereof. The collateral dredging and pain relieving ointment is prepared from the following raw materials in percentage by mass: camphor, borneol, menthol, absolute ethyl alcohol, collateral dredging and pain relieving volatile oil, a surfactant, collateral dredging and pain relieving extract, tartaric acid, purified water, partially neutralized sodium polyacrylate, a cross-linking agent, an adhesive, glycerol, EDTA-2Na (Ethylene Diamine Tetraacetic Acid) and a filling agent. The plaster disclosed by the invention is high in application comfort, breathable, free from aching feeling after being uncovered, free from residue on skin and not sticky when being in contact with sweat; the use of an organic solvent is basically avoided in the production process; the matrix contains components such as water and glycerol, has the effects of moistening the skin and promoting skin hydration, and is free of irritation and sensitization to the skin; repeated uncovering and pasting can be achieved, and the viscosity influence is small.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a sustained-release oral soluble film and a preparation method thereof, and the sustained-release oral soluble film comprises a sustained-release pellet core, a film forming material, a plasticizer and a flavoring agent. According to the invention, a multi-unit drug delivery system is provided, a small-particle-size film-controlled sustained-release pellet core is firstly prepared as an intermediate and then added into a film-forming material to form the oral-soluble film preparation, so that the limitation that the oral-soluble film is only applied as a quick-release preparation generally is broken through; the invention provides a slow-release oral soluble film preparation which is convenient for accurately dividing dosage, has better taste, can improve the medicine taking convenience and compliance of patients and has stable and lasting blood concentration.

The invention relates to an enzyme response antibacterial carbon dot and a preparation method and application thereof.The carbon dot takes a copper-doped carbon dot as a core and is covalently grafted with a hyaluronic acid shell layer through amidation reaction to form a composite nano material Cu-CDs (at) HA, specifically, soluble copper salt and folic acid are subjected to a hydrothermal reaction to obtain the copper-doped carbon dot, carboxyl is activated through EDC / NHS in a buffer system, and the carbon dot is prepared. And performing grafting reaction with hyaluronic acid to obtain a target product. The hyaluronidase-containing antibacterial composition can be specifically degraded and release antibacterial components under the action of hyaluronidase, shows good bacterial responsive bactericidal performance, has the minimum inhibitory concentrations of 8 g / mL and 16 g / mL for staphylococcus aureus and escherichia coli respectively, and has peroxidase-like activity and free radical scavenging capacity. The antibacterial carbon dots can be used for preparing intelligent wound dressings, antibacterial coatings and other biomedical materials, and have the advantages of responsive drug release, efficient antibacterial property and promotion of wound repair.

The invention discloses a degradable nanocellulose sustained-release drug-loaded film and a preparation method thereof, and belongs to the technical field of drug functional materials. The preparation method comprises the following steps: mixing and stirring microcrystalline cellulose and 64wt% sulfuric acid solution, centrifuging, dialyzing to be neutral, and freeze-drying to obtain CNCs; cNCs, NaIO4 and water are mixed and then subjected to a light-shielding reaction, ethanol precipitation is added, dialysis purification is conducted, freeze drying is conducted, and formylation modified CNCs are obtained; mixing and stirring the aldehyde modified CNCs, sericin, polyvinyl alcohol, water and a target drug to obtain a core layer solution; dissolving a polylactic acid-glycolic acid copolymer into a mixed solution of chloroform and DMF (Dimethyl Formamide) to obtain a shell solution; the core layer solution and the shell layer solution are subjected to coaxial electrostatic spinning forming to obtain the drug-loaded fiber, then the drug-loaded fiber is subjected to biomimetic mineralization surface modification to obtain the degradable nanocellulose sustained-release drug-loaded film, the drug loading rate is increased, the mechanical property of the drug-loaded film is improved, and the sustained-release and release-controllable effects are achieved.

The invention belongs to the technical field of pharmaceutical preparations, and relates to a compound I patch composition, a compound I patch and a preparation method thereof. The patch composition comprises the following components in parts by weight: 0.5-12 parts of a pharmaceutical active component, 10-30 parts of a penetration enhancer, 15-56 parts of a crystal inhibitor and 35-57 parts of an acrylic acid pressure-sensitive adhesive, the patch composition also comprises solvent dimethyl sulfoxide and absolute ethyl alcohol, and the residual quantity of the dimethyl sulfoxide is not less than 2.0%; wherein the active pharmaceutical ingredient is a compound I, and the structural formula of the compound I is shown in the specification. According to the patch composition containing the compound I, the medicine stability is high, medicine crystallization and impurity generation are effectively avoided or reduced, and the patch containing the compound I has higher stability and safety; the patch composition containing the compound I has more appropriate drug permeability, so that the patch containing the compound I has higher drug effectiveness.

The invention relates to a plaster for dredging collaterals of muscles and bones. The invention mainly comprises a back lining layer, a medicine layer and a protective layer, glycerol and sodium alginate are used as a matrix, and the medicine layer is obtained by mixing a traditional Chinese medicine extract prepared from asiatic toddalia root, polygala japonica, short-pedicel aconite root, fructus alpiniae oxyphyllae, datura seeds, asarum heterotropoides, artificial musk and borneol with the matrix; the obtained muscle and bone collateral dredging plaster acts on an affected part through the medicine layer with a certain thickness, has good effects of dispelling wind, eliminating dampness, promoting blood circulation and dredging collaterals, and has a health care effect on uncomfortable parts such as neck, shoulders, waist, knee joints and the like caused by wind, cold and damp evil.

The subject invention relates to a therapeutic patch, its manufacture and use wherein the patch comprises: a fabric layer made of synthetic fibers stretchable in both directions along a substantially orthogonal transverse axis of the patch, an adhesive layer on said face side of the base layer, an active agent dispersed in said adhesive layer, and optionally, a penetration enhancing agent in said adhesive layer.

To provide an external preparation having a markedly improved percutaneous absorbency, compared to conventional loxoprofen external preparations and preparation techniques thereof, by blending loxoprofen with a specific active ingredient.SOLUTION: A skin external preparation contains the following (a) to (e) components: (a) loxoprofen, (b) l-menthol, (c) ethanol, (d) one or more selected from nonanoic acid vanillylamide, glycyrrhetinic acid, benzyl nicotinate ester and vitamin E, and (e) chlorpheniramine maleate.SELECTED DRAWING: None

Pharmaceutical formulations of novel indole compounds and psilocybin analogs are manufactured, provided in novel oral, transdermal, and nasal pharmaceutical compositions for use to treat neurological, mood or abuse diseases and disorders.

The invention provides a nanocrystalline composite oral ulcer film agent as well as a preparation method and application thereof. The nanocrystalline composite oral ulcer film agent comprises a waterproof backing layer and a drug-loading adhesion layer coated on the waterproof backing layer, the drug-loaded adhesion layer comprises a macromolecular hydrogen bond compound formed by a weakly acidic polymer and a nonionic proton receptor polymer, and a nanocrystalline drug. Compared with the prior art, the preparation method has the advantages that the polyacrylic acid polymer and the nonionic cellulose polymer interact to form IPC serving as an adhesion layer film-forming material, the nanocrystals are loaded into the adhesion layer film-forming material, the waterproof backing layer is coated with the adhesion layer film-forming material, and the oral ulcer film agent is prepared after drying and cutting. The obtained film agent has good comfort and adhesive power, shows good drug stability and permeation promotion performance, can be used as a carrier of an oral administration route, prolongs the drug action time and improves the curative effect. The preparation method of the film agent is simple and easy for industrial mass production.

The invention provides an enhanced transdermal delivery beauty patch containing efficient active PDRN (DNA sodium) and a preparation method thereof, the enhanced transdermal delivery beauty patch is composed of a needle body layer and a backing layer, the needle body layer comprises the following components by mass: 5-15% of PDRN with a molecular weight of 50-300 kDa, 10-20% of a polymer with a molecular weight of 50-300 kDa, 5-15% of a polymer with a molecular weight of 50-300 kDa, 5-15% of a polymer with a molecular weight The content of the zwitterionic polymer carrier is 30%-50%, and the zwitterionic polymer carrier is formed by copolymerizing methacryloylethyl sulfobetaine and hyaluronic acid. The composition has the characteristics of good mechanical properties, rapid dissolution, high activity retention and efficient permeation promotion, can be used for treatment of pigmentation after acne and skin barrier repair, and comprehensively improves the skin repair effect and practicability.

To provide crystalline forms of tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine (A2-73), dosage forms comprising the same, and methods of using the same for treatment.SOLUTION: The present disclosure provides crystalline forms of tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine (A2-73), in freebase or salt forms. Also there are disclosed pharmaceutical formulations and dosage forms comprising the disclosed crystal forms, and methods of using crystalline A2-73 in dosage forms for neuroprotection including treatment of neurodegenerative and other diseases.SELECTED DRAWING: None

The present invention relates to the technical field of medicine. More specifically, the present invention relates to a microneedle composition containing an active component, and a preparation method therefor and the use thereof. The microneedle composition containing an active component contains an active component, a biodegradable polymer material, a surfactant, and the balance of a solvent, wherein on the basis of the total weight of the microneedle composition, the weight percentage of the active component is 1-15%, the weight percentage of the biodegradable polymer material is 0.1-15%, and the weight percentage of the surfactant is 0.05-5%.

The invention relates to the technical field of traditional Chinese medicine, in particular to a composition for relieving knee osteoarthritis and a preparation method of an external patch thereof, the composition comprises a Zhuang medicine component and sweet tea liquid, the Zhuang medicine component comprises a main medicine, a male medicine and an auxiliary medicine, and the main medicine comprises dendropanax dentiger, pseudo-ginseng and radix clematidis; the male medicine is prepared from litsea cubeba, tea pepper, cortex cinnamomi and prostrate centipede; the upper medicine comprises polygonum cuspidatum, philippine flemingia root, bark of himalayan coralbean, radix zanthoxyli and fructus liquidambaris. Compared with the prior art, Zhuang medicine components of a main common helper are configured on the basis of KOA Zhuang medicine pathogenesis and Zhuang medicine pathology, and all the medicines are combined for use, so that the purposes of dispelling wind, eliminating dampness, regulating and smoothing a dragon road and a fire road, promoting blood circulation to arrest pain, tonifying deficiency and strengthening muscles and bones are achieved, and the purpose of treating knee osteoarthritis is achieved; meanwhile, animal experiments and clinical experiments verify the efficacy of the external application agent, and the external application agent has the effect of relieving knee osteoarthritis.

The invention discloses a micro-fluidic chip, a drug-loaded microsphere, a drug-loaded microneedle and a drug-loaded microneedle patch, belongs to the technical field of drug delivery systems, particularly relates to the field of drug-loaded microneedle patches based on a micro-fluidic technology, and is particularly used for realizing collaborative treatment of acupoint stimulation and drug sustained release. The problems that in the prior art, an existing medicine carrying microsphere preparation method is uneven in particle size, high in medicine burst release rate and low in encapsulation efficiency, traditional acupuncture treatment operation dependence is high, and acupuncture point stimulation and medicine slow release cannot be coordinated are solved. The drug-loaded microneedle patch comprises a medical stainless steel main needle group, a hydrogel drug-loaded auxiliary needle group and an adhesive tape. The micro-fluidic chip, the drug-loaded microsphere, the drug-loaded microneedle and the drug-loaded microneedle patch are suitable for realizing synergistic interaction of drug sustained release and acupoint stimulation.

A wound / bandage protector configured as a wrap, a sock / mitten, or a bandage may be made out of stretchable material. The wrap may have one or more fastening straps as well as possibly a first catch fastening surface. The sock / mitten may have a fastening strap and a sheath. The wrap, the sock / mitten, and the bandages may have apertures and aperture covers. In addition, the wound / bandage protectors as well as the bandages may have diamond or triangular gauze configurations with the gauze pad having three or four primary corners, the primary corners of the gauze pad in most instances being oriented towards edges of the body portion or length of width tangents of the body portion, preferably mid-points or mid-sections of the length or width tangents or body portion edges.

Pharmaceutical compositions having enhanced active component permeation properties are described.