1210results about "Sheet delivery" patented technology

Pharmaceutical formulations of novel indole compounds and psilocybin analogs are manufactured, provided in novel oral, transdermal, and nasal pharmaceutical compositions for use to treat neurological, mood or abuse diseases and disorders.

The invention belongs to the technical field of pharmaceutical preparations, and relates to a compound I patch composition, a compound I patch and a preparation method thereof. The patch composition comprises the following components in parts by weight: 0.5-12 parts of a pharmaceutical active component, 10-30 parts of a penetration enhancer, 15-56 parts of a crystal inhibitor and 35-57 parts of an acrylic acid pressure-sensitive adhesive, the patch composition also comprises solvent dimethyl sulfoxide and absolute ethyl alcohol, and the residual quantity of the dimethyl sulfoxide is not less than 2.0%; wherein the active pharmaceutical ingredient is a compound I, and the structural formula of the compound I is shown in the specification. According to the patch composition containing the compound I, the medicine stability is high, medicine crystallization and impurity generation are effectively avoided or reduced, and the patch containing the compound I has higher stability and safety; the patch composition containing the compound I has more appropriate drug permeability, so that the patch containing the compound I has higher drug effectiveness.

Pharmaceutical formulations of novel indole compounds and psilocybin analogs are manufactured, provided in novel oral, transdermal, and nasal pharmaceutical compositions for use to treat neurological, mood or abuse diseases and disorders.

The invention provides a rigidity-flexibility variable multifunctional optical genetic implantable probe and a preparation method thereof. The probe comprises a thin film electrode layer and a rigidity-flexibility variable shape memory layer arranged at the bottom of the thin film electrode layer. The micro LED is integrated in the flexible nerve probe through contact type laser transfer printing to serve as a light stimulation light source, the preparation success rate is remarkably increased, heat radiated outwards during light stimulation is reduced, and damage to brain tissue of the brain caused by high-Young-modulus optical fibers is avoided; meanwhile, a rigid-flexible variable shape memory layer is also integrated, so that the Young modulus of the probe is high when the in-vitro temperature is relatively low, fixed-point implantation can be directly carried out without an auxiliary tool, the Young modulus of the probe is reduced along with the rise of the body temperature after the probe is implanted into the body, and the probe finally adapts to the mechanical tissue strength of the brain; therefore, the implantation efficiency and the mechanical adaptability of the probe to brain tissues are improved, and micron-scale accurate implantation of the probe, neuron-scale positioning of electrical stimulation and light stimulation points and long-term stable recording of electrophysiological signals are realized.

The present invention provides a nanofiber membrane having dual scale porosity, which is manufactured by a phase separation electrospinning method. The nanofiber membrane is composed of interfibrous pores and surface pores which are interconnected, thereby enhancing air permeability, diffusion rate and filtration performance. The methods employ solvents having different evaporation rates to induce phase separation during electrospinning, resulting in high porosity structures. The nanofiber membranes are suitable for use in air filtration, medical dressings, drug delivery systems, and diagnostic test paper, thereby improving performance characteristics, such as reducing pressure drop, enhancing diffusion, and increasing diagnostic sensitivity. The method enables cost-effective and scalable production while ensuring consistency of fiber morphology.

A topical application of nitric oxide may be provided by two separate containers, each containing an active component media to produce nitric oxide when combined. For example, a nitrite component media may be contained in one dispenser and an acidified component media may be contained in another dispenser. Each dispenser may dispense the respective component media as a foam or a solution. They can be combined to initiate the production of nitric oxide and the mixture of resultant foam is applied topically to treat various skin disorders or wounds.

Pharmaceutical formulations of novel indole compounds and psilocybin analogs are manufactured, provided in novel oral, transdermal, and nasal pharmaceutical compositions for use to treat neurological, mood or abuse diseases and disorders.

The present invention proves a non-woven fabric, and a liquid-impregnated sheet and wiping sheet which use the non-woven fabric. The non-woven fabric contains phosphorus-modified polyester-based fibers that have a modified part modified by a phosphorus compound, wherein: the basis weight is not more than 150 g / m2; and the phosphorus-modified polyester-based fibers are tangled with each other by three-dimensional entanglement in at least the thickness direction. The non-woven fabric may further include cellulose-based fibers and / or adhesion core-sheath composite fibers.

A composition suitable for preparing an orally soluble film having improved properties, particularly good elasticity (low brittleness), rapid disintegration, and low tackiness, is disclosed. Orally soluble films prepared from such compositions, as well as medical uses and therapeutic methods using such orally soluble films, are also disclosed.

A transdermal drug delivery device includes a reservoir, a transdermal membrane, a piston, a control rod, a spring, and a rotational cam. The reservoir is configured to hold a formulation. The transdermal membrane is configured to allow the formulation from the reservoir to pass therethrough. The piston is configured to move into the reservoir. The control rod is attached to the piston and includes a plurality of teeth thereon. The spring is configured to apply force to the control rod in the direction of the reservoir. The rotational cam has a first camming surface and a second camming surface that are configured to engage with the plurality of teeth. The rotational cam, when rotated, is configured to disengage the first camming surface from a first tooth of the plurality of teeth, thereby allowing the spring to advance the piston into the reservoir to expel the formulation onto the transdermal membrane.

The invention discloses a traditional Chinese medicine liniment for treating rheumatoid arthritis and a preparation process thereof, the traditional Chinese medicine liniment is composed of a wind-dispelling and pain-relieving liquid medicine and auxiliary materials, the wind-dispelling and pain-relieving liquid medicine contains eight traditional Chinese medicines of thorny elaeagnus root, erythrina bark, kadsura longepedunculata root, waxberry root, ardisia crenata, rose mallow root, glabrous sarcandra herb and wikstroemia canescens root, and is prepared by ultrasonic extraction; the auxiliary materials comprise polyvinyl alcohol, a chitosan-acetic acid solution, glycerol, azone, methylparaben, vanillyl butyl ether and ethanol. The liniment is short in film forming time and good in stability, has excellent transdermal absorption performance and antioxidant activity, can remarkably relieve joint swelling of RA model mice, improve the pain threshold value, improve joint pathological injuries, achieve local precise long-acting administration, reduce side effects of the whole body and improve patient compliance, is suitable for clinical treatment of RA, and has a wide application prospect. The problems that an existing rheumatoid arthritis treatment medicine is large in side effect, and a traditional Chinese medicine preparation is short in efficacy duration and inconvenient to use are solved.

The invention belongs to the technical field of skin disease treatment and medicine, and particularly relates to an external pharmaceutical composition for treating atopic dermatitis and a preparation method and application thereof. The medicine composition is liquid medicine composed of blumea balsamifera oil, perfoliote knotweed herb and piper cubeba extract and is specially used for treating the atopic dermatitis (AD). According to the composition, the blumea balsamifera oil is innovatively used as a main component and cooperates with the perfoliote knotweed herb and the piper cubeba extract to form an efficient treatment scheme, and the curative effect of the composition is remarkably superior to that of a traditional method for singly using the blumea balsamifera oil. Experiments prove that the composition can effectively improve the skin barrier function, regulate immune disorder, reduce the levels of serum IgE and TSLP and inflammatory factors IL-4 and IFN-gamma, and reduce inflammatory cell infiltration, so that the AD symptom is relieved, and the recurrence rate is reduced.

The present application relates to a kind of high elasticity double-network hydrogel and its preparation method and application, belong to new material preparation field.A kind of high elasticity double-network hydrogel, the double-network hydrogel is formed by the crosslinking of first network and second network, wherein the first network is the gel network that gelatin-TG enzyme is crosslinked, the second network is the gel network that sodium alginate-calcium ion is crosslinked.The stability of gelatin-TG enzyme and the elasticity of sodium alginate-Ca 2+ The present application combines the stability of gelatin-TG enzyme and the elasticity of sodium alginate-Ca 2+ , significantly improves the elasticity and form stability of the non-backing fever patch;Through active ingredient pretreatment process, the problem of menthol and camphor being difficult to dissolve in water is solved, ensuring uniform dispersion;The preparation process is controllable, the product performance is stable, meets the dynamic fitting demand under human activity scene, effectively solves the technical pain points of traditional fever patch, has significant practical value and market prospect.

The invention provides a spraying film agent and a preparation method thereof. The spraying film agent comprises a phase A and a phase B, wherein the phase A is uniformly dispersed in the phase B; wherein the phase A is a water-in-oil structure microsphere, and the water-in-oil structure microsphere is formed by wrapping a water-soluble active substance with a surfactant; and the phase B comprises a low-polarity organic solvent and a film-forming agent. On the basis of a reverse micelle technology, a water-soluble active substance is wrapped by a surfactant to form a water-in-oil structure microsphere, in the structure, the hydrophilic end of the surfactant inwards forms a water pool for accommodating the water-soluble active substance, and the hydrophobic end of the surfactant outwards enables the water-soluble active substance to be uniformly dispersed in a low-polarity solvent; therefore, the uniform and stable dispersion of the water-soluble active substance in the low-polarity solvent phase is realized. The contradictions that a traditional water-soluble polymer matrix is slow in film forming and water-soluble active ingredients cannot be stably dispersed in a low-polarity quick-drying solvent are solved.

The present invention pertains to use of sodium diacetate (NaHAC2) as an antimicrobial agent against bacteria growing in biofilms. The aspects of the invention include a wound care product comprising sodium diacetate, a kit comprising a wound care product, and a method of treating an infected wound.

This product provides a heel exfoliation pack that allows for concentrated application of pharmaceuticals and other substances to the heel, effectively removing calluses from the heel. [Solution] The device comprises a holding member 11 made of a sheet material, impregnated with a pharmaceutical, quasi-drug, or cosmetic that removes calluses from the heel, and used in contact with the heel to hold the pharmaceutical, quasi-drug, or cosmetic; a fixing member 12 made of a watertight sheet material that covers the heel to fix the holding member 11 in contact with the heel; and a bag member 13 made of a watertight sheet material that is a bag-shaped member that encloses at least the part of a person's foot from the ankle downwards when the holding member 11 is fixed by the fixing member 12. The pharmaceutical, quasi-drug, or cosmetic is a chemical peeling solution containing a skin peeling component, a skin softening component, a moisturizing component, and a surfactant component, with 4.0 to 6.0% by mass of lactic acid as the α-hydroxy acid, and the overall pH is adjusted to 3.5 or higher.

The invention discloses a bone strengthening and pain relieving preparation and a preparation and use method thereof, and belongs to the technical field of traditional Chinese medicine. The preparation is prepared from unprocessed radix aconiti, unprocessed radix aconiti kusnezoffii, radix angelicae, radix cynanchi paniculati, ardisia crenata, radix salviae miltiorrhizae, cortex phellodendri, radix clematidis, peach kernels, flos carthami, cortex acanthopanacis, rhizoma drynariae, ground beetles, herba asari, short-pedicel aconite roots, borax and borneol. The auxiliary materials comprise sesame oil and minium. The prescription has the treatment rules and treatment methods of setting bones, relieving pain, clearing damp, dredging collaterals, diminishing swelling and dissipating blood stasis. The traditional Chinese medicine is mainly used for treating traumatic injury, soft tissue contusion and arthralgia, and belongs to qi stagnation and blood stasis type. The preparation is used by spreading the preparation on a non-woven fabric or oil paper. The plaster is heated and softened, and is pasted on an affected part. The traditional Chinese medicine has the symptoms of onset caused by trauma or strain, local swelling, stabbing pain, numbness of limbs, joint movement disadvantage or aggravated arthralgia when encountering wind-cold. The tongue is light, the tongue coating is thin white or white greasy, and the pulse is tight or soft.

The invention provides a traditional Chinese medicine composition, a black plaster and application of the black plaster. The traditional Chinese medicine composition comprises the following components in parts by mass: 5-30 parts of wormwood, 8-35 parts of chinaroot greenbrier, 100-250 parts of semen brassicae, 45-60 parts of radix angelicae, 8-35 parts of ligusticum wallichii, 10-35 parts of rhizoma dioscoreae nipponicae, 10-35 parts of salvia miltiorrhiza, 8-35 parts of angelica sinensis, 15-40 parts of lamiophlomis rotata, 10-35 parts of radix saposhnikoviae, 8-35 parts of poria cocos, 5-30 parts of rhizoma drynariae, 5-30 parts of black radix aconiti lateralis preparata, 8-35 parts of safflower, 8-35 parts of rhizoma polygonati, 20-45 parts of sambucus williamsii, 15-40 parts of psammosilene tunicoides and 8-35 parts of aspongopus. , 45-60 parts of dragon's blood, 10-35 parts of myrrh, 20-45 parts of obscured homalomena rhizome, and 30-60 parts of madder. The traditional Chinese medicine composition has the effects of promoting blood circulation to remove blood stasis, expelling wind and removing cold, relaxing tendons and activating collaterals and clearing away heat and toxic materials, and can effectively prevent and / or treat pain, numbness and swelling of shoulders, necks, waists, knees, joints and other parts.

The present invention relates to shaped polyvinyl alcohol (PVOH) based elastomeric matrixes for ophthalmic uses and, more particularly, but not exclusively, to such matrixes that are degradable.

Ganoderma lucidum spore oil and its use in preparing anti-cancer-related fatigue medicine. The Ganoderma lucidum spore oil has a triglyceride content of more than 90% and no Ganoderma lucidum triterpenoid compounds are detected. The Ganoderma lucidum spore oil is obtained by supercritical carbon dioxide extraction, eluting with a mixture of petroleum ether and ethyl acetate through a silica gel column, concentrating under reduced pressure, and drying in vacuum. The Ganoderma lucidum spore oil is found to significantly improve fatigue caused by cancer and has good safety, and therefore can be applied to preparing anti-cancer-related fatigue medicine.

The present disclosure provides a delivery system 1 comprising a fibrous substrate 10 with continuous pores 13 and a composition homogenously bonded to the pores 13. The fibrous substrate 10 comprises at least a predetermined percentage of cotton and one or more materials selected from the group of consisting spandex, nylon, silver and antimicrobial mesh. The composition comprises a predetermined percentage of beeswax and a predetermined percentage of mineral oil. The predetermined percentage of beeswax is greater than the predetermined percentage of mineral oil.

The application relates to the field of high polymer materials, in particular to an exosome composite material for treating periodontitis and a preparation method thereof. The exosome composite material comprises the following raw materials in parts by weight: 10-20 parts of a chitosan derivative, 10-20 parts of sodium hyaluronate, 1-5 parts of zein, 0.5-1 part of exosomes, 0.1-0.3 parts of phosphonodipeptide sodium and 60-70 parts of deionized water. The exosome composite material can inhibit periodontal pathogenic bacteria, reduce the expression of proinflammatory factors by inhibiting the signal pathways such as NF-kappa B, and thus relieve periodontal tissue inflammation.

The present invention relates to a patch containing an improved release liner for the treatment of various skin conditions.

The invention discloses application of a yang-warming and cold-dispelling traditional Chinese medicine composition in preparation of a medicine for improving cold limbs, and belongs to the field of traditional Chinese medicines. The prescription consists of folium artemisiae argyi, cassia twig, ligusticum wallichii, notopterygium root, divaricate saposhnikovia root, ginger, pepper, safflower, radix clematidis, radix aconiti carmichaeli, dried ginger and cinnamon according to a specific mass part ratio. The prescription disclosed by the invention has the effects of warming channels and expelling cold, and promoting blood circulation to remove meridian obstruction, and is mainly used for improving the symptoms such as cold hands and feet, intolerance of cold and sensation of chill, joint crymodynia and the like caused by insufficiency of yang qi and congealing cold in meridians. The invention also provides a preparation method of dosage forms such as an application agent of the prescription. Clinical tests show that the prescription preparation, especially the acupoint application agent, can obviously improve the symptoms, the total effective rate can reach 93.3%, the safety is good, and a safe, effective and convenient-to-use external treatment choice is provided for related diseases.

The application belongs to the technical field of traditional Chinese medicines, specifically to the technical field of Miao medicine, and more specifically to a traditional Chinese medicine composition with analgesic effect, an external preparation thereof and a preparation method. The traditional Chinese medicine composition is composed of the following raw medicinal materials in parts by weight: Tongguuxiang 260-340, Heiguteng 160-240, Jianghuang 160-240, Danggui 130-170, Qingfengteng 130-170, Yinyanghuo 80-120, Sibukaowa 80-120, the external preparation is processed by weighing, crushing, mixing, coating, slicing, pasting and packaging, and the traditional Chinese medicine composition or the external preparation can significantly treat or improve the pain symptoms of diseases such as rheumatism, cervical spondylosis and lumbago, and has the characteristics of significant curative effect and quick effect.

There are disclosed psychedelic and entactogen compounds, the use of such compounds in the treatment of diseases associated with a serotonin 5-HT2 receptor, pharmaceutical compositions such as tablet compositions and kits containing the compounds, methods of delivering the compounds in a mist via inhalation, and methods of treating diseases or disorders associated with a serotonin 5-HT2 receptor, such as central nervous system (CNS) disorders or psychological disorders with the compounds of the invention.

The present application relates to the technical field of wound repair, and provides a traditional Chinese medicine composition for promoting wound healing and a preparation method thereof.The traditional Chinese medicine composition comprises a first traditional Chinese medicine composition and a second traditional Chinese medicine composition which are applied to the acute phase and the repair proliferation phase.The former comprises naked flower purple perilla extract, nectarine leaf extract, purple perilla extract, dragon's blood micro powder, spironast extract, centella asiatica volatile oil, rhubarb extract, borneol, mussel mucin, medicinal glycerol and purified water.The latter comprises red algae extract, nectarine leaf extract, radix astragali extract, panax notoginseng total saponins, aloe extract, dendrobium officinale extract, sea buckthorn extract, pinctada martensii purified peptide, snail glycosaminoglycan, medicinal glycerol and purified water.The composition can play the roles of antibiosis, anti-inflammation, hemostasis, analgesia and astringency in the acute phase, and can promote angiogenesis, collagen synthesis and epithelial regeneration in the repair proliferation phase, so that the wound is rapidly repaired and healed.