The present invention provides a disease pain eliminating drug patch and a preparation method thereof, wherein the raw materials comprise panax notoginseng, safflower, dragon's bone, garter snake, centipede, eupolyphaga sinensis walker, eucommia ulmoides, rhizoma homalomenae, achyranthes bidentata blume, crinis carbonisatus, red lead, daemonorops draco, typhonium giganteum engl, saposhnikovia divaricata, frankincense, phryma leptostachya, corium elephatis, myrrh, 40-60 parts by weight of rosin, sesame oil, calomelas, talcum powder, strychnos nux-vomica l, rubus phoenicolasius maxim, yellow wax and lead powder. According to the present invention, the method has advantages of low cost and simple preparation process, and the disease pain eliminating drug patch has effects of significant local blood circulation promoting, surrounding tissue nutrition improving, swelling subsiding, inflammation eliminating, pain relieving, toxicity removing, dampness removing, tissue regeneration promoting, and bone spur eliminating.