32 results about "Drug patch" patented technology

The present invention relates to a transdermal drug delivery system comprising a dermal drug delivery patch and a heating element compartment securable to the dermal drug delivery patch. A freely transferrable heating element is securable within the heating element compartment. A drug can be administered transdermally using the present invention by placing the dermal drug delivery patch upon a patient's skin at an administration site. A heating element compartment is secured to the dermal drug delivery patch and a freely transferrable heating element is placed within the heating element compartment. The heating element provides controlled heat to the dermal drug patch and the patient's skin aid thereby improves dermal drug administration.

The present invention relates to a transdermal drug delivery system comprising a dermal drug delivery patch and a heating element compartment securable to the dermal drug delivery patch. A freely transferrable heating element is securable within the heating element compartment. A drug can be administered transdermally using the present invention by placing the dermal drug delivery patch upon a patient's skin at an administration site. A heating element compartment is secured to the dermal drug delivery patch and a freely transferrable heating element is placed within the heating element compartment. The heating element provides controlled heat to the dermal drug patch and the patient's skin and thereby improves dermal drug administration.

The present invention is directed toward a formulation for supplying additional drug for delivery in a transdermal drug delivery device. The invention comprises a drug, such as fentanyl that is capable of transdermal delivery, and a solution having a pre-designed solubility for the drug. The solution dissolves only a portion of said drug and allows a significant portion of the drug to remain undissolved in solution, thus providing extra drug to be delivered at a consistent, controlled delivery rate. The invention may used in conjunction with controlled heat.

A fully integrated, independently accurately performing, active transdermal medicament patch includes a flexible substrate with an adhesive-coated therapeutic face carrying a medicament reservoir. A circuit non-removably carried on the substrate and driven by a light-weight power source causes a substantially constant current to flow for a predetermined therapy period through the reservoir and the skin against which the therapeutic face is disposed. Net electrical polarity of the medicament determines the interconnection of circuit and power source to skin. The circuit includes a field effect transistor or an operational amplifier with a zener diode or a voltage regulator. A timer non-removably carried on the substrate disables the circuit following functioning the therapy period. An active transdermal medicament delivery system employs a single patch or pair of patches physically and electrically connected by a distensible tether.

A medicated patch is provided which is covered with a liner that enables one to remove the liner unconsciously and readily without losing the initial stickiness of the medicated patch. The external medicated patch includes a backing, an aqueous adhesive drug-containing matrix that is spread substantially entirely over one surface of the backing, and a liner that is larger in size than the surface of the drug-containing matrix to which the liner is attached. The liner larger in size than the surface of the drug-containing matrix to which the liner is attached includes an unattached area that extends from the surface of the drug-containing matrix, or an unattached slack portion that projects upward from the surface of the drug-containing matrix at a position on the surface of the drug-containing matrix.

A medicinal picking for percutaneous absorption of medicine is composed of a substrate layer, the medicine-bearing layer consisting of nano-class Chinese medicine layer, nano-class far infrared layer, percutaneous absorption promoting layer and slow-releasing agent layer, an adhesive layer, and a protecting layer. Its preparing process is also disclosed. Its advantages are high medical effect and air permeability, and no irritation to skin.

The invention discloses an application of adipose tissue-derived stromal cells in treating premature ovarian failure, and belongs to the technical field of a biological medicine. Adipose tissue-derived stromal cells and its excreted cell factors, and other components at a certain ratio are applied to form adipose tissue-derived stromal cells; then the adipose tissue-derived stromal cells are prepared to be injection fluid and a drug patch; the injection fluid is injected to the zone where a focus locates through a local target injection method, and then the patch is pasted to a patient's navel; through an electromagnetic impulse generator, a drug is intermittently stimulated, and the secretion of follicle-stimulating hormone is promoted, ovary endometrium can be effectively repaired, the functional ovulation is promoted, and premature ovarian failure is effectively treated. In short, the application has the advantages of being safe and effective, higher in controllability and strong inpracticability.

The invention discloses a method for preparing nano drug-carrying capsule-loaded alginate fibers. The method comprises the steps of preparing a nano drug-carrying capsule by taking sodium alginate as a matrix; adding the nano drug-carrying capsule in a sodium alginate spinning solution; and preparing nano drug-carrying capsule-loaded alginate fibers through wet spinning. According to the method, the loss of drugs in the spinning process can be reduced, and because a drug is wrapped in the capsule, so that the drug can be effectively prevented from degenerating, and different kinds of drugs can be loaded in the capsule. In addition, the capsule is prepared by taking sodium alginate as the matrix, compared with homogeneous fibers, the alginate fibers have good interface compatibility, and the drug-carrying capsule is in nanoscale, does not affect the spinnability and the final fiber performances of the sodium alginate spinning solution. The method disclosed by the invention can be applied to medical materials such as dressings, gauzes, bandages, drug patches, drug pads and the like, and achieves the effects of reducing wound infection and inflammation possibility, stimulating cell proliferation and implementing other actions so as to accelerate wound healing; the method is also applied to the local chemotherapy after tumor surgeries.

The invention discloses a portable micro-needle array drug patch and a preparation method and transdermal drug delivery method thereof. An intelligent portable device is used as a power source, a current controller and a bluetooth IC module are embedded in an electrode slice, the current controller is in communication connection with the intelligent portable device through the bluetooth IC module,and the current controller controls the electric current flow transmitted to a micro-needle array according to command information sent by the intelligent portable device. The problem of large and expensive exogenous equipment in the existing permeation enhancing technology is solved, the portable micro-needle array drug patch is portable, and the transdermal controlled release of drug can be effectively realized by controllable and intelligent means.

Apparatus (50) is described for use with a drug on a drug patch (28), the drug patch including a drug side and a back side. An absorbent material (54) is configured to be disposed on a surface (56) and underneath the drug patch. A squeezing device (52) having a squeezing surface is configured to squeeze the drug patch together with the absorbent material. Other embodiments are also described.

Apparatus (50) is described for use with a drug on a drug patch (28), the drug patch including a drug side and a back side. An absorbent material (54) is configured to be disposed on a surface (56) and underneath the drug patch. A squeezing device (52) having a squeezing surface is configured to squeeze the drug patch together with the absorbent material. Other embodiments are also described.

The invention provides a microneedle patch capable of generating heat, and a preparation method and application thereof. Methyl propene acidulated hyaluronic acid (m-HA) serves as a matrix to load rosiglitazone (Rosi) to produce painless soluble transdermal delivery drug patches, and nano black phosphorus sheets are synthesized to serve as backing for the soluble transdermal delivery drug patches;and the prepared microneedle patch can rapidly generate heat and heat up under excitation of near-infrared light, and drug release can be accelerated.

The present invention relates to a drug composition for treating mouth ulcer. The drug composition comprises 10-20% of lophatherum gracile, 4-17% of cape jasmine, 5-15% of Chinese gall, 8-27% of dandelion, 10-26% of honeysuckle, 3-12% of common anemarrhena, 4-18% of snakegourd root and 14-35% of honey. The formula of the drug composition of the present invention has effects of heat clearing, fire purging, detoxification and antibacterial effect. The drug composition can be prepared into an oral solution and a drug patch film according to the formula, a better effect is provided when concurrently using the oral solution and the drug patch film.

The invention relates to a drug patch and equipment with heating and cooling functions, and belongs to the technical fields of make-up and skin care products as well as medical equipment. The drug patch and equipment are utilized for nursing or treatment of the chest, abdomen, face, elbow joints, knee joints and several other parts of a human body. The equipment comprises the drug patch, a heating and cooling device, a DC power supply device, a feeding device and an intelligent control device, wherein the drug patch comprises two or more layers of closed film bag-shaped patches; closed channels are formed in the drug patch; a quick connector B is arranged at the lower end of the drug patch; tiny capillary porosities are formed in both the closed channels and the closed film bag-shaped patches; a drug can be separated out through the tiny capillary porosities, and permeate into a corresponding part of a user; a plurality of bulges are arranged on the drug patch and have a massage function, so that the drug using effect of the drug patch is improved. The drug path and equipment are rapid in cooling and heating, free of noise and low in energy consumption; through adoption of the drug patch, skin pores can be expanded or shrunk, so that the drug can be sufficiently absorbed, and the nursing or treating function of the drug can be more obvious.

The present invention discloses a novel chemical drug patch ketoprofen paster and a preparation method thereof. The novel chemical drug patch ketoprofen paster comprises a styrene-isoprene-styrene triblock copolymer, a styrene-isoprene diblock copolymer, a tackifier, a softener and an antioxygen; the patch has the characteristics that the stimulation to skins is very slight, an adhesive is free from the stimulation to the skins, the drug stabilization in long-term storage is good, the pasting with the skins is good, the repeatable pasting is realized, pasting is kept when contacted with water, particularly the pasting with knees, elbows and other parts; the adhesive in the patch comprises components in percentage by weight: 10%-55% of the styrene-isoprene-styrene triblock copolymer and the styrene-isoprene diblock copolymer totally, less than 22% of polyisobutene with high molecular weight, less than 30% of polyisobutene with middle molecular weight, less than 25% of polyisobutene with low molecular weight, 10%-60% of the tackifier, and 12%-55% of the softener; the antioxygen accounts for 0.01%-2.5% of the sum amount of framework materials.

The invention is a method for treating a heart disease, in particular acute myocardial infarction (AMI) in a subject comprising the step of administering to the subject a Tjp1 inhibitor, wherein administration of said Tjp1 inhibitor promotes cardiomyocyte proliferation. The invention further includes use of Tjp1 inhibitor in the manufacture of a medicament for a heart disease, a patch, and a nucleic acid encoding a Tjp1 inhibitor. In a particular embodiment, the Tjp1 inhibitor is a nucleic acid, i.e. an siRNA or shRNA of Tjp1. The invention also includes administration of said Tjp1 inhibitor in combination with Neuregulin-1 (NRG1), Fibroblast growth factor (FGF), Vascular endothelial growth factor (VEGF) or Follistatin-like 1 (Fst1) and wherein said inhibitor is delivered in an adeno-associated virus of serotype 9 (AAV 9).

The invention relates to an intelligent ultrathin flexible electronic automatic drug delivery patch which is composed of a non-woven fabric, a circuit layer, a drug layer and a non-sticky paper layer. The circuit layer comprises a circuit board. The circuit board is used as a basic carrier. The non-woven fabric, the drug layer and the non-sticky paper layer are arranged on the circuit board. The non-woven fabric is laid on the outer side of the circuit layer and fixed to the circuit board through adhesives. The drug layer is fixed to the center of the circuit board of the circuit layer and fixed to the bottom layer through adhesives. The non-sticky paper layer is arranged on the drug layer. When the intelligent ultrathin flexible electronic automatic drug delivery patch is used, non-sticky paper is opened, an adhesive body is exposed, and the intelligent ultrathin flexible electronic automatic drug delivery patch can be stuck to a diseased region for use. According to the intelligent ultrathin flexible electronic automatic drug delivery patch, the two fields of the medical technology and the modern electronic technology are combined, an intelligent electronic control unit is added on the basis of a traditional drug patch treatment, drug is delivered automatically and intermittently, various modes can be selected for output, drug absorption is facilitated, blood circulation of the treated portion is facilitated, the role in improving the treatment effect is played, different users can select different output modes, and the unsuitable feeling of the skin is greatly relieved when the treatment is facilitated.

The invention relates to a photosensitive medicament patch, which comprises a light-isolating protection layer, an adhesive plaster layer, a membrane layer and a medicament core and is characterized in that the medicament core formed by encapsulating a medicament with phospholipids and is attached onto the membrane layer, and the membrane layer is made of a natural biomaterial homogeneous membrane. According to the photosensitive medicament patch provided by the invention, not only can the requirement of a parenteral medicament administration manner of a photosensitive medicament be met and hypocrellin be enriched in a target tissue, but also the photosensitive medicament can be prevented from auto polymerization in a water phase, so that the purpose of increasing phototherapy activity is increased. In addition, the natural biomaterial homogeneous membrane has favorable biodegradability and biocompatibility, has no toxicity and antigenicity, has favorable functions of air permeability, membrane formability, spinnability, blood coagulation resistance, and capability of promoting wound healing, corrosion protection and antisepsis, and the like, and serves as a medicament slow-release carrier in the invention.

The invention belongs to the technical field of composite materials, and particularly discloses a bio-optical composite material, a preparation method and an application thereof. The bio-optical composite material comprises the following raw materials in parts by weight: 0.5-3 parts of mica, 0.5-2 parts of mirabilite, 0.5-3 parts of haematite, 0.5-1 part of gypsum, 0.5-1 part of magnetite, 0.5-3 parts of cinnabar, 0.5-2 parts of tourmaline, 0.5-3 parts of alum and 0.5-2 parts of medical stone. The raw material fine powder of the bio-optical composite material is evenly mixed in a high-speed mixer, and is irradiated for 12-24 hours by a laser with 457-600nm frequency band and a continuous output power of 400mW. The composite material can convert infrared waves emitted by human bodies to generate short-wave biological waves, can promote cell metabolism, improve cell pathology and improve cell physiology, has the functions of quickly relieving pain, repairing cell damage, dispelling glandhyperplasia, improving cell hypoxia, enhancing muscle fiber strength, strengthening physiological state of human organs and the like, can be used for medical treatment and human body rehabilitation health care, such as preparing multiple medical patches, eyeglass frames and other human body contact articles for daily use.

The invention relates to the technical field of baby products, in particular to a perineum nursing patch for a baby. The perineum nursing patch comprises a nursing patch body, the nursing patch body comprises a trapezoidal fixing patch, a perineum hole is formed in the middle of the lower part of the trapezoidal fixing patch, a plurality of round patches A are arranged on the trapezoidal fixing patch, and the bottom of the trapezoidal fixing patch is connected with a drug patch; the drug patch is composed of a drug liner and a main drug layer with discutient on the drug liner; at the surface of the drug liner, a plurality of vent holes are formed in two sides of the drug layer; three connecting patch belts are arranged at the left lateral surface of the drug liner, an auxiliary drug layer is arranged on the three connecting patch belts, and the belt ends of the three connecting patch belts are connected with block-shaped patches B; a strip-shaped mat is arranged at the right lateral surface of the drug liner. The perineum nursing patch for the baby is simple in structure, is convenient to operate, makes the baby feel comfortable and does not stimulate the defecation of the baby.

The invention discloses an application of adipose tissue-derived stromal cells in treating premature ovarian failure, and belongs to the technical field of a biological medicine. Adipose tissue-derived stromal cells and its excreted cell factors, and other components at a certain ratio are applied to form adipose tissue-derived stromal cells; then the adipose tissue-derived stromal cells are prepared to be injection fluid and a drug patch; the injection fluid is injected to the zone where a focus locates through a local target injection method, and then the patch is pasted to a patient's navel; through an electromagnetic impulse generator, a drug is intermittently stimulated, and the secretion of follicle-stimulating hormone is promoted, ovary endometrium can be effectively repaired, the functional ovulation is promoted, and premature ovarian failure is effectively treated. In short, the application has the advantages of being safe and effective, higher in controllability and strong inpracticability.

The present invention discloses a novel chemical drug patch ketoprofen paster and a preparation method thereof. The novel chemical drug patch ketoprofen paster comprises a styrene-isoprene-styrene triblock copolymer, a styrene-isoprene diblock copolymer, a tackifier, a softener and an antioxygen; the patch has the characteristics that the stimulation to skins is very slight, an adhesive is free from the stimulation to the skins, the drug stabilization in long-term storage is good, the pasting with the skins is good, the repeatable pasting is realized, pasting is kept when contacted with water, particularly the pasting with knees, elbows and other parts; the adhesive in the patch comprises components in percentage by weight: 10%-55% of the styrene-isoprene-styrene triblock copolymer and the styrene-isoprene diblock copolymer totally, less than 22% of polyisobutene with high molecular weight, less than 30% of polyisobutene with middle molecular weight, less than 25% of polyisobutene with low molecular weight, 10%-60% of the tackifier, and 12%-55% of the softener; the antioxygen accounts for 0.01%-2.5% of the sum amount of framework materials.

The invention provides an external drug patch for the umbilicus, comprising an adhesive plaster layer, a drug powder, a film layer and an adhesive sheet layer; the drug powder includes the following raw materials in parts by weight: 5-20 parts of Huoxiang, 1-8 parts of Woody, 30-53 parts of cumin, 13-32 parts of cloves, 30-52 parts of white cardamom, 48-75 parts of pepper, 87-116 parts of longan meat, 18-39 parts of Artemisia argyi. The present invention adopts classification and batch pulverization, and grinds it into micron to submicron traditional Chinese medicine powder through an ultra-fine pulverizer. In contact with the navel, the efficacy of the medicine is greatly improved, and the onset speed is fast.

The invention relates to a biphasic transdermal drug delivery system and a preparation method thereof, which is obtained by using the drug-loaded ethosome / natural material nanofiber membrane as a receiver to receive electrosprayed drug-loaded ethosome composite microspheres. The invention has good skin compatibility, air permeability and water permeability, and will be softer when wet, and more closely adhered to the skin, and is an ideal material for a transdermal drug delivery patch.

A biopatch, a bioheater, a biosensor and a bioelectronic patch device are provided.The biopatch comprises a polymer film comprising a biopolymer and a drug loaded in the polymer film. The biopolymer may comprise one or more than one of a bioabsorbable polymer, a biodegradable polymer and a biocompatible polymer. The biopolymer may comprise oxidized starch. The drug may comprise a first drug chemically combined with the oxidized starch and a second drug physically combined with the oxidized starch.The bioheater comprises a heater comprising biometal. The biometal may comprise Mg or Fe. The heater can be controlled wirelessly by an alternating magnetic field.A biosensor according to one embodiment of the present inventive concept comprises an inductor and a capacitor connected to the inductor, wherein the capacitor comprises a first electrode, a second electrode facing the first electrode and a dielectric disposed between the first electrode and the second electrode, each of the inductor, the first electrode and the second electrode comprises biometal, and the dielectric comprises a biopolymer having a glass transition temperature in a range of 36˜42° C. A biosensor according to another embodiment of the present inventive concept comprises an inductor and a capacitor connected to the inductor, wherein the capacitor comprises a first electrode, a second electrode facing the first electrode and a dielectric disposed between the first electrode and the second electrode, a change in a dielectric constant of the dielectric is transmitted to an external device through a resonance frequency change with the inductor, and the external device measures temperature around the biosensor by measuring the resonance frequency change wirelessly.A bioelectronic patch device according to one embodiment of the present inventive concept comprises a drug patch comprising a polymer film comprising a biopolymer and a drug loaded in the polymer film, and a heater adjacent to the drug patch to heat the drug patch. A bioelectronic patch device according to another embodiment of the present inventive concept comprises a drug patch comprising a polymer film comprising a biopolymer and a drug loaded in the polymer film, a first protection layer disposed on the drug patch, a heater disposed on the first protection layer and heating the drug patch, a temperature sensor disposed on the first protection layer, spaced apart from the heater and measuring temperature of the heater, and a second protection layer covering the heater and the temperature sensor on the first protection layer.

A beauty / medication patch including a substrate, an outer layer, and a medication lotion; the outer layer being made of a degradable material being disposed on the substrate; one or a plurality of micro-probe array being disposed on a surface of the outer layer; the medication lotion being coated between the substrate and the outer layer, and / or admixed in the substrate; the patch being attached to a human skin, the micro-probe array piercing through a stratum corneum layer of the human skin and naturally being degraded by human skin or absorbed and metabolized by a human body; and the medication lotion penetrating into the skin and being absorbed by the human skin.

A dressing material for knee joint inflammation, used in conjunction with drug patches, including a bionic support part and a functional lining. The bionic support part is a solid shell material that is 3D printed according to the human knee joint data model, and the functional lining It is a flexible lining material with a certain thickness that is 3D printed on the inner side of the bionic support part. The flexible lining material is a flexible mesh structure or a flexible weaving structure. Attached, preferably, at least the material of the functional liner includes a functional material, the functional material preferably includes a gold-silver core-shell nanomaterial, and the functional liner can include a high-porosity first liner and a low-porosity second liner . According to the principle of bionics, the present invention utilizes the moldless and rapid prototyping characteristics of 3D printing to manufacture non-disposable dressing materials, which are used in conjunction with conventional disposable drug patches to protect and treat knee joints and provide good sticking effects. It also helps the medicine work.

The present invention provides a disease pain eliminating drug patch and a preparation method thereof, wherein the raw materials comprise panax notoginseng, safflower, dragon's bone, garter snake, centipede, eupolyphaga sinensis walker, eucommia ulmoides, rhizoma homalomenae, achyranthes bidentata blume, crinis carbonisatus, red lead, daemonorops draco, typhonium giganteum engl, saposhnikovia divaricata, frankincense, phryma leptostachya, corium elephatis, myrrh, 40-60 parts by weight of rosin, sesame oil, calomelas, talcum powder, strychnos nux-vomica l, rubus phoenicolasius maxim, yellow wax and lead powder. According to the present invention, the method has advantages of low cost and simple preparation process, and the disease pain eliminating drug patch has effects of significant local blood circulation promoting, surrounding tissue nutrition improving, swelling subsiding, inflammation eliminating, pain relieving, toxicity removing, dampness removing, tissue regeneration promoting, and bone spur eliminating.

A biopatch, a bioheater, a biosensor and a bioelectronic patch device are provided.The biopatch comprises a polymer film comprising a biopolymer and a drug loaded in the polymer film. The biopolymer may comprise one or more than one of a bioabsorbable polymer, a biodegradable polymer and a biocompatible polymer. The biopolymer may comprise oxidized starch. The drug may comprise a first drug chemically combined with the oxidized starch and a second drug physically combined with the oxidized starch.The bioheater comprises a heater comprising biometal. The biometal may comprise Mg or Fe. The heater can be controlled wirelessly by an alternating magnetic field.A biosensor according to one embodiment of the present inventive concept comprises an inductor and a capacitor connected to the inductor, wherein the capacitor comprises a first electrode, a second electrode facing the first electrode and a dielectric disposed between the first electrode and the second electrode, each of the inductor, the first electrode and the second electrode comprises biometal, and the dielectric comprises a biopolymer having a glass transition temperature in a range of 36˜42° C. A biosensor according to another embodiment of the present inventive concept comprises an inductor and a capacitor connected to the inductor, wherein the capacitor comprises a first electrode, a second electrode facing the first electrode and a dielectric disposed between the first electrode and the second electrode, a change in a dielectric constant of the dielectric is transmitted to an external device through a resonance frequency change with the inductor, and the external device measures temperature around the biosensor by measuring the resonance frequency change wirelessly.A bioelectronic patch device according to one embodiment of the present inventive concept comprises a drug patch comprising a polymer film comprising a biopolymer and a drug loaded in the polymer film, and a heater adjacent to the drug patch to heat the drug patch. A bioelectronic patch device according to another embodiment of the present inventive concept comprises a drug patch comprising a polymer film comprising a biopolymer and a drug loaded in the polymer film, a first protection layer disposed on the drug patch, a heater disposed on the first protection layer and heating the drug patch, a temperature sensor disposed on the first protection layer, spaced apart from the heater and measuring temperature of the heater, and a second protection layer covering the heater and the temperature sensor on the first protection layer.