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367 results about "Hard tissue" patented technology

Hard tissue (also termed calcified tissue) is tissue which is mineralized and has a firm intercellular matrix. The hard tissues of humans are bone, tooth enamel, dentin, and cementum. The term is in contrast to soft tissue.

System and Method for Aligning 3-D Imagery of a Patient's Oral Cavity in an Extended Reality (XR) Environment

A method for aligning 3D objects in an extended reality (XR) system involves obtaining 3D objects from a volumetric imager or surface scanner, where the volumetric imager captures a three-dimensional voxel array representing an anatomical structure and the surface scanner generates a polygonal mesh or point cloud of the same structure. The method includes detecting a set of points on the 3D objects by identifying distinct anatomical landmarks, such as facial landmarks for soft tissue or tooth landmarks for hard tissue, and assigning each point a unique identifier. A video feed from XR goggles or a prerecorded video is obtained, providing real-time or prerecorded imagery of the patient's anatomical structure from various angles. Corresponding points on the video feed that align with the set of points detected on the 3D objects are identified using image processing techniques, ensuring accurate correspondence. The registered 3D objects are rendered to match the corresponding points on the patient's anatomical structure, with the alignment switching between soft tissue points when the patient's mouth is closed and hard tissue points when the patient's mouth is open for enhanced precision.
Owner:DIAGNOCAT

Tissue-Removing Catheter with Flexible and Stiff Portions

The present disclosure provides a tissue-removing catheter for removing tissue in a body lumen. The tissue-removing catheter includes an elongate drive member and a tissue-removing element. The elongate drive member has proximal and distal ends with a length and a longitudinal axis extending between the proximal and distal ends. The elongate drive member is sized and shaped to be received in the body lumen and rotates about its longitudinal axis. The elongate drive member further includes first and second longitudinal portions. The first longitudinal portion is proximal to and stiffer than the second longitudinal portion. The tissue-removing element is operatively coupled to the distal end of the elongate drive member and rotates by the elongate drive member to remove the tissue in the body lumen.
Owner:MEDTRONIC VASCULAR INC

Image generation method and system based on oral cavity imaging

PCT designated stage expiredWO2025010983A1Image enhancementImage analysisFeature extraction3d image
Disclosed in the present invention are an image generation method and system based on oral cavity imaging. The method comprises: acquiring CT image data of an oral cavity to be processed, and constructing an oral cavity skeleton model on the basis of the CT image data; extracting skeleton features of the oral cavity skeleton model, and, by means of a preset healthy soft and hard tissue oral cavity model database and on the basis of the skeleton features, covering the oral cavity skeleton model with soft tissue to obtain a first oral cavity model; performing three-dimensional laser scanning on said oral cavity so as to construct a second oral cavity model, comparing the first oral cavity model with the second oral cavity model to obtain a soft tissue difference area of the first oral cavity model and the second oral cavity model, and marking the soft tissue difference area in the second oral cavity model; acquiring optical image information of a target acquisition area in said oral cavity, and performing soft tissue feature extraction on the optical image information; and covering the second oral cavity model with extracted soft tissue features to obtain a three-dimensional image model of said oral cavity, and then performing oral image acquisition on the three-dimensional image model so as to generate an oral cavity image.
Owner:CANCER CENT OF GUANGZHOU MEDICAL UNIV

Antibacterial synergy-mineralization regulation difunctional nano material as well as preparation method and application thereof

ActiveCN120713863AAntibacterial agentsInorganic phosphorous active ingredientsHydroxypropyltrimethyl ammonium chloride chitosanHard tissue
The invention provides an antibacterial synergy-mineralization regulation difunctional nano material as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. The preparation method comprises the following steps: mixing a disodium hydrogen phosphate solution and a calcium chloride solution to obtain an amorphous calcium phosphate suspension; mixing the amorphous calcium phosphate suspension with a tannic acid solution to obtain an ACP-TA suspension; and finally, mixing the ACP (at) TA suspension and the hydroxypropyl trimethyl ammonium chloride chitosan solution to obtain the bifunctional nano material. A cross-linked shell is formed through the electrostatic adsorption effect of tannic acid and hydroxypropyl trimethyl ammonium chloride chitosan of the antibacterial layer, amorphous calcium phosphate is effectively wrapped, the crystallization process of amorphous calcium phosphate can be remarkably delayed, long-acting release of calcium and phosphorus ions is ensured, the antibacterial function can be effectively achieved, and the service life of the coating is prolonged. An ideal local microenvironment is provided for remineralization of tooth hard tissue, and finally biomimetic mineralization of enamel and deep mineralization plugging of dentinal tubules are achieved.
Owner:GUANGXI MEDICAL UNIVERSITY

Craniomaxillofacial hard tissue deletion repair method based on general repair model

The invention provides a cranio-maxillofacial hard tissue deletion repair method based on a general repair model, and relates to the technical field of jaw defect reconstruction, the method comprises the following steps: constructing a cranio-maxillofacial hard tissue general repair model by using a plug-and-play conditional attention mechanism and a query generator based on curvature perception; inputting the cranio-maxillofacial hard tissue point cloud data into a cranio-maxillofacial hard tissue general repair model, and training by using a weighted loss function to obtain a trained cranio-maxillofacial hard tissue general repair model; performing de-noising processing on the missing repair point cloud features to obtain de-noised missing repair point cloud features; and carrying out point cloud gridding modeling processing by using the denoised deletion repair point cloud features to obtain a cranio-maxillofacial hard tissue deletion repair result, and completing the deletion repair of the cranio-maxillofacial hard tissue. The problem that repair and reconstruction of hard tissues at the head part are difficult to solve uniformly is solved.
Owner:BEIJING UNIV OF POSTS & TELECOMM

Implant position planning method, auxiliary planting system, medium and product

The invention discloses an implant position planning method, an auxiliary planting system, a medium and a product. The method comprises the following steps: generating a three-dimensional oral cavity segmentation result based on tooth image data, and determining soft and hard tissue associated information corresponding to each target tooth position based on the tooth image data; inputting the three-dimensional oral cavity segmentation result, the form data of the tail end of the mechanical arm, the target tooth positions, and the attribute information and soft and hard tissue association information of the to-be-implanted body corresponding to each target tooth position to a preset planning model to obtain predicted planning positions corresponding to each target tooth position; on the basis of the predicted planning positions corresponding to the target tooth positions, a feasibility analysis result is obtained, under the condition that the feasibility analysis result meets a preset feasible judgment condition, a planning display result is generated, and the feasibility analysis result comprises the operation range of the tail end of the mechanical arm and / or the stress analysis result of each target tooth position. And the reliability of predicting the planned position is improved.
Owner:SHENZHEN YANGSHAN MEDICAL TECHNOLOGY CO LTD

Preparation method and application of organic-inorganic composite hydrogel with high strength, high inorganic ratio and suitable degradability

The invention discloses a preparation method and application of high-strength, high-inorganic-ratio and degradable organic-inorganic composite hydrogel, and belongs to the technical field of biomedical tissue engineering. The hydrogel is prepared from the following components in percentage by weight: 30 to 70 percent of calcium phosphate nano-cluster and 30 to 70 percent of sodium alginate. The organic-inorganic composite hydrogel is beneficial to proliferation and mineralization of bone cells, and more ideal bone guidance is realized. Experimental results prove that the material has good cytocompatibility, can quickly promote rat skull defect repair (8 mm limit bone injury repair time is shortened to 4 weeks), and has a more remarkable healing effect compared with a contrast autogenous bone graft material with an optimal clinical repair effect. The high-strength organic-inorganic composite hydrogel prepared by the invention is of a single-network structure, shows good mechanical properties, also has excellent degradability matched with tissues, and is beneficial to hard tissue repair.
Owner:ZHEJIANG UNIV

Digital denture model design method based on jaw position relation

The invention relates to the technical field of three-dimensional point cloud data processing, in particular to a digital denture model design method based on a jaw position relation. Based on comparison of the initial three-dimensional point clouds under different opening amplitudes, a soft tissue interference area where soft tissue movement possibly exists and a hard tissue boundary false displacement area corresponding to point cloud overlapping caused by a scanning view angle are obtained; according to the method, the movement trend of each point in the false displacement area of the hard tissue boundary is corrected in combination with the movement trend of the adjacent area in the oral cavity, so that the corrected three-dimensional point cloud obtained after correction is more accurate, the accuracy of recording according to the corrected three-dimensional point cloud is higher, and the accuracy of the generated digital denture is improved.
Owner:SHIMMER COMPUTERIZED DENTAL TECH CO LTD

Adhesive hydrogel for oral periodontal tissue regeneration and preparation method thereof

The invention discloses an adhesive hydrogel for oral periodontal tissue regeneration and a preparation method thereof, gelatin and polyacrylic acid are used as main raw materials, and a photo-crosslinking method is used as a basis to prepare the adhesive hydrogel; the adhesive hydrogel has good tissue adhesion, can be tightly adhered to wet soft and hard tissue surfaces, and overcomes the defect that the oral periodontal filling material is difficult to fix clinically at present. The adhesive hydrogel has high porosity after completely absorbing water and swelling, and pores in the surface and inside of the adhesive hydrogel are communicated with each other, so that the adhesive hydrogel can provide more space for growth of oral periodontal tissues, and is suitable for ingrowth of cells and regeneration of the oral periodontal tissues.
Owner:AFFILIATED STOMATOLOGICAL HOSPITAL OF NANJING MEDICAL UNIV

Tooth model set and multi-layer root canal therapy practice model

The utility model provides a tooth model kit and a multi-layer root canal therapy practice model. A hard tissue part of a teaching tooth model is made of a colorless transparent printing material, and a soft tissue part of the teaching tooth model is made of a colored printing material. The hard tissue part of the endodontotomy practice model is made of a non-transparent 3D printing material, and the dental pulp part is made of a colored printing material with the color different from that of the hard tissue part. The dental crown part of the root canal therapy practice model is made of a non-transparent printing material, the dental root part is made of a colorless transparent printing material, and the dental pulp part is made of a colorless transparent adhesive body ground printing material. A dental crown part of the multi-layer root canal therapy practice model is made of a non-transparent printing material, a tooth root part is made of a colorless transparent printing material, a semitransparent colored layer with a preset thickness is arranged at the position, close to a dental pulp part, of the tooth root part, and the dental pulp part is made of a colorless transparent adhesive body ground printing material. The tooth model kit provided by the utility model is higher in simulation degree on teeth, and the simulation result is displayed more clearly.
Owner:PEKING UNIV SCHOOL OF STOMATOLOGY

Silk fibroin hydrogel containing bivalent bioactive metal ions and preparation method thereof

The invention provides silk fibroin hydrogel containing divalent bioactive metal ions and a preparation method of the silk fibroin hydrogel, and belongs to the technical field of soft and hard tissue repair and medical dressings. The invention provides a silk fibroin hydrogel preparation method, which comprises: S1, dissolving degummed silk by using a dissolving agent to prepare a silk fibroin stock solution; s2, dialyzing the silk fibroin stock solution in water dissolved with divalent metal salt to obtain a silk fibroin composite solution; s3, carrying out heat preservation treatment on the silk fibroin composite solution, then applying shearing force, and incubating to obtain the silk fibroin hydrogel containing the metal ions. The preparation method of the silk fibroin hydrogel is simple, the pH value does not need to be adjusted in the preparation process, a gelatinizing agent does not need to be added, two cross-linking mechanisms of beta-folding cross-linking of a silk fibroin hydrophobic chain segment are promoted under the action of shearing force by chelating and cross-linking a silk fibroin hydrophilic chain segment through divalent metal ions, so that a silk fibroin aqueous solution is rapidly gelatinized, and the silk fibroin hydrogel is prepared. And meanwhile, one or more divalent metal ions can be compounded according to expected purposes, and good operability, biological safety and multifunctionality are achieved.
Owner:SHANGHAI MOYANG BIOTECHNOLOGY CO LTD

Predicting palatal geometry of a patient for palatal expansion treatment

Devices, systems, and methods for predicting palatal geometry are provided. In some embodiments, a system for predicting an anatomy of a patient's palate includes one or more processors and a memory operably coupled to the one or more processors and storing instructions that, when executed by the one or more processors, cause the system to perform operations including accessing a first digital representation including an initial geometry of soft tissue corresponding to a patient's palate, determining an initial geometry of hard tissue of the patient's palate, predicting a change in the hard tissue during a treatment, using the predicted change in the hard tissue to predict a change in the soft tissue during the treatment, and outputting a second digital representation including a predicted geometry of the patient's palate at a future treatment stage of a treatment plan, based on the predicted change in the soft tissue.
Owner:ALIGN TECHNOLOGY INC

Complete denture tooth arrangement virtual simulation method and system

The invention relates to the technical field of information, and particularly provides a complete denture arrangement virtual simulation method and system, and the method comprises the steps: obtaining the medical record data of a user; the medical record data comprises edentulous jaw soft and hard tissue data, jaw bone data, alveolar ridge morphological parameters, jaw position relation data and facial feature data; determining an initial dental arch curve based on the medical record data; inputting the initial dental arch curve and preset aesthetic parameters into a preset deep learning model to obtain a plurality of initial tooth arrangement schemes; screening the plurality of initial tooth arrangement schemes according to tooth arrangement constraint conditions to obtain tooth arrangement schemes meeting constraints; the tooth position and angle of each tooth arrangement scheme meeting the constraint are adjusted until the preset occlusion balance condition is met, and the first tooth arrangement scheme is obtained, so that the tooth arrangement scheme efficiency of the complete dentures can be improved on the premise that the quality of the tooth arrangement scheme of the complete dentures is guaranteed.
Owner:TIANJIN MEDICAL COLLEGE

Thrombectomy devices with lateral and vertical bias

PCT designated stage expiredWO2025038964A1Excision instrumentsCatheterThrombusBlood vessel injury
Thrombectomy systems having curved tubular cutting devices, and methods of using them, are provided. These systems, devices, and methods can (i) effectively cut and remove a variety of thrombus tissue from blood vessels, including soft, tough, and hard tissue; (ii) safely self-collect and remove tissue particles to avoid release of emboli; and, (iii) effectively treat a blood vessel with a reduced risk of suffering vessel injuries that can lead to increased stenosis.
Owner:AVANTEC VASCULAR CORP

Thrombectomy devices with lateral and vertical bias

Thrombectomy systems having curved tubular cutting devices, and methods of using them, are provided. These systems, devices, and methods can (i) effectively cut and remove a variety of thrombus tissue from blood vessels, including soft, tough, and hard tissue; (ii) safely self-collect and remove tissue particles to avoid release of emboli; and, (iii) effectively treat a blood vessel with a reduced risk of suffering vessel injuries that can lead to increased stenosis.
Owner:INFRAREDX INC

Application of monocalcium aluminate in premixed dental filling material, premixed dental filling material and preparation method of premixed dental filling material

PendingCN120324260AImpression capsDentistry preparationsBiocompatibilityMonocalcium aluminate
The invention discloses an application of monocalcium aluminate in a premixed dental filling material, the premixed dental filling material and a preparation method of the premixed dental filling material, the premixed dental filling material takes monocalcium aluminate as a main hydraulic material, calcium oxide is supplemented as a curing accelerator and an expanding agent, and the premixed dental filling material can also comprise calcium pyrophosphate, calcium carbonate, calcium carbonate and calcium carbonate. The biological hydrogel paste with excellent injectable performance is prepared. The material keeps fluid under a sealed condition, and is hydrated, solidified and hardened after being placed in a physiological environment and contacted with physiological body fluid. According to the present invention, by using the excellent biocompatibility and the biological activity of the monocalcium aluminate, the premixed aluminate hydrogel dental filling material is prepared from the monocalcium aluminate, and can be used for medical applications and dental applications, including the fields of pulp capping, root canal therapy, hard tissue repair and the like.
Owner:KUNMING QINGCHENG MEDICAL TECH LTD

Insertion type tissue clamping device and transmission piece thereof

According to the plug-in type tissue clamping device and the transmission part thereof, in the plug-in type tissue clamping device, when a clamping part clamps large tissue or hard tissue, an operator can apply larger acting force to the clamping part through the transmission part. Before the clamping piece completes the expected meshing effect, the clamping and abutting part is always opposite to the limiting part and cannot move to the locking window, at the moment, even if larger force is applied to the transmission piece, due to the fact that the limiting part limits the clamping and abutting part, an integral transmission structure is always kept between the pull rod and the separation head, and the clamping and abutting part cannot move to the locking window. The pull rod can drive the separation head to continue to move towards the locking window until the clamping and abutting part also moves to the locking window, the butt joint can push the clamping and abutting part to move towards the two sides of the separation head, the butt joint can be disengaged from the butt joint groove, and the clamping and abutting part can be clamped into the locking window. After the plastically deformed clamping and abutting part is locked to the locking window, the clamping and abutting part cannot return and rebound, and it can be guaranteed that the clamping piece is in a reliable clamping and closing state all the time.
Owner:NINGBO XINWELL MEDICAL TECH CO LTD

Dental operation plan generation method and device, computer device and storage device

The invention belongs to the technical field of data processing, and particularly relates to a dental operation scheme generation method and device, a computer device and a storage device. The method comprises the following steps that at least two kinds of three-dimensional image data of the same patient are obtained, the first kind of three-dimensional image data at least comprises hard tissue information, and the second kind of three-dimensional image data at least comprises soft tissue surface information; performing spatial registration on the first three-dimensional image data and the second three-dimensional image data in the same world coordinate system to generate a unified three-dimensional fusion model; identifying a key anatomical marker in the three-dimensional fusion model; and generating a dental operation scheme in the three-dimensional fusion model according to the identified key anatomical markers. A dental operation scheme is intelligently generated through four steps of data, registration, recognition and generation.
Owner:SHENZHEN PEOPLES HOSPITAL

Digital orthodontic treatment planning system

The invention discloses a digital orthodontic treatment planning system, and relates to the technical field of orthodontics. The system comprises a data acquisition module, a three-dimensional model construction module, a case database module, a diagnosis model construction module and a treatment planning module. The data acquisition module is used for acquiring oral scanning and CBCT scanning data and generating an oral three-dimensional model; the three-dimensional model construction module performs fusion processing on the two types of models to construct a three-dimensional gum model; the case database module is used for constructing a case database on the basis of soft tissues, CBCT projection measurement hard tissues and three-dimensional gum model characteristics; the diagnosis model construction module constructs an intelligent diagnosis model through a self-adaptive deep neural network and generates a treatment scheme set; and the treatment planning module combines patient data to judge malformation, formulate a scheme, and output a feasible treatment scheme after collision detection, model adjustment and scheme evaluation.
Owner:HANGZHOU STOMATOLOGICAL HOSPITAL CO LTD

Oral scanning method and oral scanning instrument based on pose information and point cloud data fusion

The invention discloses a mouth scanning method and mouth scanning instrument based on pose information and point cloud data fusion, and belongs to the field of medical instruments, and the method comprises the following steps: S1, selecting facial feature points which are fixed relative to a position relation between an upper jaw alveolar ridge and a lower jaw alveolar ridge as facial marking points for marking; s2, calculating the spatial positions of a mouth scanning sensor and an attitude sensor fixed on the mouth scanning instrument relative to the facial mark point; s3, obtaining multi-angle point cloud data; s4, obtaining full-port point cloud data; s5, obtaining an intraoral scanning model; s6, reconstructing an edentulous jaw soft and hard tissue three-dimensional digital model; and S7, calculating the soft tissue thickness of an edentulous region in the edentulous soft and hard tissue three-dimensional digital model by using image processing software. According to the oral scanning method and the oral scanning instrument based on the pose information and the point cloud data fusion, errors occurring in the splicing process of the oral scanning instrument only depending on the point cloud data can be remarkably reduced or avoided, and the precision and the efficiency of edentulous jaw digital impression are improved.
Owner:BEIJING SHIJITAN HOSPITAL CAPITAL MEDICAL UNIVERSITY

Thrombectomy devices with lateral and vertical bias

Thrombectomy systems having curved tubular cutting devices, and methods of using them, are provided. These systems, devices, and methods can (i) effectively cut and remove a variety of thrombus tissue from blood vessels, including soft, tough, and hard tissue; (ii) safely self-collect and remove tissue particles to avoid release of emboli; and, (iii) effectively treat a blood vessel with a reduced risk of suffering vessel injuries that can lead to increased stenosis.
Owner:INFRAREDX INC

Improved hard tissue decalcification liquid and application thereof

The invention provides an improved hard tissue decalcification solution and application thereof, and relates to the technical field of hard tissue decalcification, the improved hard tissue decalcification solution is obtained by mixing EDTA, ammonia water and water, and Ca < 2 + > ions are jointly chelated by the ammonia water and the EDTA in a water environment; the mass volume ratio of the EDTA to the ammonia water to the water is (140 to 280) g to (20 to 400) mL to (1000 to 2000) mL; the pH value of the improved hard tissue decalcification liquid is 6.5-7.5, the decalcification speed is accelerated by accurately controlling the pH value, the decalcification period is shortened by about 50%, it is guaranteed that antigen-antibody combination is not affected after decalcification, mild decalcification is achieved, and a high-quality sample is provided for subsequent histological research.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY

Systems and methods for scanning teeth for dental restorations

An intraoral scanning method includes receiving a plurality of intraoral scans of a dental point during an intraoral scanning session, generating a three-dimensional (3D) surface of the dental point from the plurality of intraoral scans, identifying hard tissue and soft tissue in at least one of a) the plurality of intraoral scans of the dental point or b) the 3D surface of the dental point, and displaying a view of the 3D surface, the first visualization is used to display a first portion of the 3D surface identified as hard tissue, and the second visualization is used to display a second portion of the 3D surface identified as soft tissue.
Owner:ALIGN TECHNOLOGY INC

Oral cavity three-dimensional model texture mapping method and device for soft tissue

The invention provides an oral cavity three-dimensional model texture mapping method and device for soft tissue. The method comprises the following steps: scanning and collecting a two-dimensional image and three-dimensional point cloud data of an oral cavity; carrying out panoramic fusion and soft and hard tissue segmentation processing on the two-dimensional image; adopting an off-line parameterization method for the separated soft tissue part, and reconstructing a soft tissue three-dimensional model by setting deformation parameters and based on iterative optimization of segmented fusion; and mapping the texture information of the two-dimensional image to the three-dimensional model, and optimizing and screening the texture information through a probability graph to complete the three-dimensional model texture mapping of the oral soft tissue. Through a differentiated and efficient data processing method, rapid and accurate oral cavity three-dimensional model reconstruction and texture mapping are realized.
Owner:WUHAN UNIV

Stereotactic device for cutting hard tissue on the cranial bone using energetic radiation

A stereotactic device for cutting hard tissue on the cranial bone using energetic radiation has a stereotactic frame (22) and a stereotactic bow (25) fastened to the stereotactic frame (22) by at least one rotary joint. A laser applicator (17) is attached to the stereotactic bow (25) and can be moved along the stereotactic bow (25) via a motorised drive (28´´), said bow also being able to be tilted on the stereotactic frame (22) via a motorised drive (28, 28´). The laser applicator (17) has a dynamic 2D beam deflection apparatus (11) for a processing laser beam (2), focusing optics (12) with an adjustable focal position and a measuring apparatus (6) or is connected thereto, by means of which the cutting depth and the remaining thickness of the cranial bone (15) in the kerf can be measured. The device permits a safe opening of the cranium which is vibration-free and silent for the patient.
Owner:FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV

Method and system for fabricating object featuring properties of a hard tissue

A method of additive manufacturing an object featuring properties of a hard bodily tissue, comprises: dispensing and solidifying a plurality of non-biological material formulations to sequentially form a plurality of hardened layers in a configured pattern corresponding to a shape of the object. The method forms voxel elements containing different material formulations at interlaced locations to provide a three-dimensional textured region spanning over the portion. The material formulations and the interlaced locations are selected such that the textured region exhibits, once hardened, a stress variation of at most ±20% over a strain range of from about 0.1% to about 0.3%.
Owner:STRATASYS LTD

Orthodontic micro-implant nail implanting method, device and system and storage medium

The invention discloses an orthodontic micro-implant nail implanting method, device and system and a storage medium. The method comprises the following steps: S1, acquiring CBCT three-dimensional data; and S2, analyzing CBCT three-dimensional data through AI artificial intelligence to calculate an optimal implantation site and an implantation direction path, and designing an implantation guide plate mounted on the surface of the dental crown. By the adoption of the technical scheme, the success rate of implanting the micro-implant nail is increased, relevant soft and hard tissue indexes in the CBCT three-dimensional image are integrated, and the burden and judgment errors of an orthodontic doctor in measurement and positioning are reduced.
Owner:HOSPITAL OF STOMATOLOGY SUN YAT SEN UNIV

Collagen biomaterial derived from abalone

The present invention is concerned with a manufactured article prepared from a biomaterial comprising isolated and purified type I collagen fibrils derived from abalone and a method of preparing such an article. The manufactured article can be prepared by 3D bioprinting, and therefore the present invention also envisages a novel bioink for a 3D bioprinter comprising an isolated and purified type I collagen fibril and cartridges containing such a bioink. The invention additionally relates to a method of isolating type I collagen fibrils from abalone. The manufactured article is useful in a number of biomedical applications including as an implantable device where it can function as a 3D bioprinted hard or soft tissue scaffold for tissue engineering.
Owner:QUEENSLAND BIOPROCESSING TECH

Calcium phosphate nanoparticles containing polyphosphate or polyphosphoric acid, preparation method of calcium phosphate nanoparticles and application of calcium phosphate nanoparticles in hard tissue repair products

The invention provides calcium phosphate nanoparticles containing polyphosphate or polyphosphoric acid, a preparation method of the calcium phosphate nanoparticles and application of the calcium phosphate nanoparticles in hard tissue repair products, the diameter of the calcium phosphate nanoparticles is 1 nm-10 microns, and the mass fraction of the polyphosphate or the polyphosphoric acid in the calcium phosphate nanoparticles is 10-80%; the calcium-phosphorus composite material is obtained by mixing a calcium-containing solution and a phosphorus-containing solution, the phosphorus-containing solution comprises polyphosphate or polyphosphoric acid and phosphate or phosphoric acid, and the concentration of polyphosphate or polyphosphoric acid in the phosphorus-containing solution is 0.1-500 mg / mL. The calcium phosphate nanoparticles containing polyphosphate or polyphosphoric acid have the advantages of small size, controllable particle size and high biological safety, the preparation method is simple to operate and low in cost, and large-scale preparation of the calcium phosphate nanoparticles can be realized; the collagen fibers can be effectively mineralized, the hard tissues such as bones and enamel can be repaired, and the method has a wide application prospect.
Owner:DALIAN UNIV OF TECH

Laser oral cavity therapeutic instrument

The invention provides a laser oral cavity therapeutic instrument which comprises a therapeutic instrument body, a laser generation assembly, a water vapor nozzle assembly and a gas-liquid-electricity external connection assembly, the laser generation assembly, the water vapor nozzle assembly and the gas-liquid-electricity external connection assembly are arranged in the therapeutic instrument body, and the laser generation assembly is used for generating a high-energy laser beam; the oral cavity treatment is performed through the high-energy laser beam; the water vapor spray head assembly is used for forming water vapor spray so as to cooperatively clean or cool the oral cavity; the gas-liquid-electricity external connection assembly is used for connecting external gas, water and electric signals so as to ensure normal work of the laser oral cavity therapeutic instrument. The laser generating assembly, the steam spray head assembly and the gas-liquid-electric external connection assembly are arranged in the therapeutic instrument body, the laser generating and emitting function and the steam mixing and cooling function are integrated into one structure, the operation requirements of basic decontamination and sterilization, soft and hard tissue cutting, bone tissue removal and the like are met, and meanwhile the therapeutic instrument has the advantages of being high in integration degree, reasonable in structure, convenient to operate and the like.
Owner:SHENZHEN SOGA TECH CO LTD