244 results about "Hard tissue" patented technology

The invention provides an antibacterial synergy-mineralization regulation difunctional nano material as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. The preparation method comprises the following steps: mixing a disodium hydrogen phosphate solution and a calcium chloride solution to obtain an amorphous calcium phosphate suspension; mixing the amorphous calcium phosphate suspension with a tannic acid solution to obtain an ACP-TA suspension; and finally, mixing the ACP (at) TA suspension and the hydroxypropyl trimethyl ammonium chloride chitosan solution to obtain the bifunctional nano material. A cross-linked shell is formed through the electrostatic adsorption effect of tannic acid and hydroxypropyl trimethyl ammonium chloride chitosan of the antibacterial layer, amorphous calcium phosphate is effectively wrapped, the crystallization process of amorphous calcium phosphate can be remarkably delayed, long-acting release of calcium and phosphorus ions is ensured, the antibacterial function can be effectively achieved, and the service life of the coating is prolonged. An ideal local microenvironment is provided for remineralization of tooth hard tissue, and finally biomimetic mineralization of enamel and deep mineralization plugging of dentinal tubules are achieved.

The invention provides a cranio-maxillofacial hard tissue deletion repair method based on a general repair model, and relates to the technical field of jaw defect reconstruction, the method comprises the following steps: constructing a cranio-maxillofacial hard tissue general repair model by using a plug-and-play conditional attention mechanism and a query generator based on curvature perception; inputting the cranio-maxillofacial hard tissue point cloud data into a cranio-maxillofacial hard tissue general repair model, and training by using a weighted loss function to obtain a trained cranio-maxillofacial hard tissue general repair model; performing de-noising processing on the missing repair point cloud features to obtain de-noised missing repair point cloud features; and carrying out point cloud gridding modeling processing by using the denoised deletion repair point cloud features to obtain a cranio-maxillofacial hard tissue deletion repair result, and completing the deletion repair of the cranio-maxillofacial hard tissue. The problem that repair and reconstruction of hard tissues at the head part are difficult to solve uniformly is solved.

The invention discloses a preparation method and application of high-strength, high-inorganic-ratio and degradable organic-inorganic composite hydrogel, and belongs to the technical field of biomedical tissue engineering. The hydrogel is prepared from the following components in percentage by weight: 30 to 70 percent of calcium phosphate nano-cluster and 30 to 70 percent of sodium alginate. The organic-inorganic composite hydrogel is beneficial to proliferation and mineralization of bone cells, and more ideal bone guidance is realized. Experimental results prove that the material has good cytocompatibility, can quickly promote rat skull defect repair (8 mm limit bone injury repair time is shortened to 4 weeks), and has a more remarkable healing effect compared with a contrast autogenous bone graft material with an optimal clinical repair effect. The high-strength organic-inorganic composite hydrogel prepared by the invention is of a single-network structure, shows good mechanical properties, also has excellent degradability matched with tissues, and is beneficial to hard tissue repair.

The invention relates to the technical field of three-dimensional point cloud data processing, in particular to a digital denture model design method based on a jaw position relation. Based on comparison of the initial three-dimensional point clouds under different opening amplitudes, a soft tissue interference area where soft tissue movement possibly exists and a hard tissue boundary false displacement area corresponding to point cloud overlapping caused by a scanning view angle are obtained; according to the method, the movement trend of each point in the false displacement area of the hard tissue boundary is corrected in combination with the movement trend of the adjacent area in the oral cavity, so that the corrected three-dimensional point cloud obtained after correction is more accurate, the accuracy of recording according to the corrected three-dimensional point cloud is higher, and the accuracy of the generated digital denture is improved.

The invention discloses an adhesive hydrogel for oral periodontal tissue regeneration and a preparation method thereof, gelatin and polyacrylic acid are used as main raw materials, and a photo-crosslinking method is used as a basis to prepare the adhesive hydrogel; the adhesive hydrogel has good tissue adhesion, can be tightly adhered to wet soft and hard tissue surfaces, and overcomes the defect that the oral periodontal filling material is difficult to fix clinically at present. The adhesive hydrogel has high porosity after completely absorbing water and swelling, and pores in the surface and inside of the adhesive hydrogel are communicated with each other, so that the adhesive hydrogel can provide more space for growth of oral periodontal tissues, and is suitable for ingrowth of cells and regeneration of the oral periodontal tissues.

The utility model provides a tooth model kit and a multi-layer root canal therapy practice model. A hard tissue part of a teaching tooth model is made of a colorless transparent printing material, and a soft tissue part of the teaching tooth model is made of a colored printing material. The hard tissue part of the endodontotomy practice model is made of a non-transparent 3D printing material, and the dental pulp part is made of a colored printing material with the color different from that of the hard tissue part. The dental crown part of the root canal therapy practice model is made of a non-transparent printing material, the dental root part is made of a colorless transparent printing material, and the dental pulp part is made of a colorless transparent adhesive body ground printing material. A dental crown part of the multi-layer root canal therapy practice model is made of a non-transparent printing material, a tooth root part is made of a colorless transparent printing material, a semitransparent colored layer with a preset thickness is arranged at the position, close to a dental pulp part, of the tooth root part, and the dental pulp part is made of a colorless transparent adhesive body ground printing material. The tooth model kit provided by the utility model is higher in simulation degree on teeth, and the simulation result is displayed more clearly.

The invention provides silk fibroin hydrogel containing divalent bioactive metal ions and a preparation method of the silk fibroin hydrogel, and belongs to the technical field of soft and hard tissue repair and medical dressings. The invention provides a silk fibroin hydrogel preparation method, which comprises: S1, dissolving degummed silk by using a dissolving agent to prepare a silk fibroin stock solution; s2, dialyzing the silk fibroin stock solution in water dissolved with divalent metal salt to obtain a silk fibroin composite solution; s3, carrying out heat preservation treatment on the silk fibroin composite solution, then applying shearing force, and incubating to obtain the silk fibroin hydrogel containing the metal ions. The preparation method of the silk fibroin hydrogel is simple, the pH value does not need to be adjusted in the preparation process, a gelatinizing agent does not need to be added, two cross-linking mechanisms of beta-folding cross-linking of a silk fibroin hydrophobic chain segment are promoted under the action of shearing force by chelating and cross-linking a silk fibroin hydrophilic chain segment through divalent metal ions, so that a silk fibroin aqueous solution is rapidly gelatinized, and the silk fibroin hydrogel is prepared. And meanwhile, one or more divalent metal ions can be compounded according to expected purposes, and good operability, biological safety and multifunctionality are achieved.

Devices, systems, and methods for predicting palatal geometry are provided. In some embodiments, a system for predicting an anatomy of a patient's palate includes one or more processors and a memory operably coupled to the one or more processors and storing instructions that, when executed by the one or more processors, cause the system to perform operations including accessing a first digital representation including an initial geometry of soft tissue corresponding to a patient's palate, determining an initial geometry of hard tissue of the patient's palate, predicting a change in the hard tissue during a treatment, using the predicted change in the hard tissue to predict a change in the soft tissue during the treatment, and outputting a second digital representation including a predicted geometry of the patient's palate at a future treatment stage of a treatment plan, based on the predicted change in the soft tissue.

The invention relates to the technical field of information, and particularly provides a complete denture arrangement virtual simulation method and system, and the method comprises the steps: obtaining the medical record data of a user; the medical record data comprises edentulous jaw soft and hard tissue data, jaw bone data, alveolar ridge morphological parameters, jaw position relation data and facial feature data; determining an initial dental arch curve based on the medical record data; inputting the initial dental arch curve and preset aesthetic parameters into a preset deep learning model to obtain a plurality of initial tooth arrangement schemes; screening the plurality of initial tooth arrangement schemes according to tooth arrangement constraint conditions to obtain tooth arrangement schemes meeting constraints; the tooth position and angle of each tooth arrangement scheme meeting the constraint are adjusted until the preset occlusion balance condition is met, and the first tooth arrangement scheme is obtained, so that the tooth arrangement scheme efficiency of the complete dentures can be improved on the premise that the quality of the tooth arrangement scheme of the complete dentures is guaranteed.

The invention discloses an application of monocalcium aluminate in a premixed dental filling material, the premixed dental filling material and a preparation method of the premixed dental filling material, the premixed dental filling material takes monocalcium aluminate as a main hydraulic material, calcium oxide is supplemented as a curing accelerator and an expanding agent, and the premixed dental filling material can also comprise calcium pyrophosphate, calcium carbonate, calcium carbonate and calcium carbonate. The biological hydrogel paste with excellent injectable performance is prepared. The material keeps fluid under a sealed condition, and is hydrated, solidified and hardened after being placed in a physiological environment and contacted with physiological body fluid. According to the present invention, by using the excellent biocompatibility and the biological activity of the monocalcium aluminate, the premixed aluminate hydrogel dental filling material is prepared from the monocalcium aluminate, and can be used for medical applications and dental applications, including the fields of pulp capping, root canal therapy, hard tissue repair and the like.

The invention belongs to the technical field of data processing, and particularly relates to a dental operation scheme generation method and device, a computer device and a storage device. The method comprises the following steps that at least two kinds of three-dimensional image data of the same patient are obtained, the first kind of three-dimensional image data at least comprises hard tissue information, and the second kind of three-dimensional image data at least comprises soft tissue surface information; performing spatial registration on the first three-dimensional image data and the second three-dimensional image data in the same world coordinate system to generate a unified three-dimensional fusion model; identifying a key anatomical marker in the three-dimensional fusion model; and generating a dental operation scheme in the three-dimensional fusion model according to the identified key anatomical markers. A dental operation scheme is intelligently generated through four steps of data, registration, recognition and generation.

The invention discloses a digital orthodontic treatment planning system, and relates to the technical field of orthodontics. The system comprises a data acquisition module, a three-dimensional model construction module, a case database module, a diagnosis model construction module and a treatment planning module. The data acquisition module is used for acquiring oral scanning and CBCT scanning data and generating an oral three-dimensional model; the three-dimensional model construction module performs fusion processing on the two types of models to construct a three-dimensional gum model; the case database module is used for constructing a case database on the basis of soft tissues, CBCT projection measurement hard tissues and three-dimensional gum model characteristics; the diagnosis model construction module constructs an intelligent diagnosis model through a self-adaptive deep neural network and generates a treatment scheme set; and the treatment planning module combines patient data to judge malformation, formulate a scheme, and output a feasible treatment scheme after collision detection, model adjustment and scheme evaluation.

The invention provides an improved hard tissue decalcification solution and application thereof, and relates to the technical field of hard tissue decalcification, the improved hard tissue decalcification solution is obtained by mixing EDTA, ammonia water and water, and Ca < 2 + > ions are jointly chelated by the ammonia water and the EDTA in a water environment; the mass volume ratio of the EDTA to the ammonia water to the water is (140 to 280) g to (20 to 400) mL to (1000 to 2000) mL; the pH value of the improved hard tissue decalcification liquid is 6.5-7.5, the decalcification speed is accelerated by accurately controlling the pH value, the decalcification period is shortened by about 50%, it is guaranteed that antigen-antibody combination is not affected after decalcification, mild decalcification is achieved, and a high-quality sample is provided for subsequent histological research.

The invention provides an oral cavity three-dimensional model texture mapping method and device for soft tissue. The method comprises the following steps: scanning and collecting a two-dimensional image and three-dimensional point cloud data of an oral cavity; carrying out panoramic fusion and soft and hard tissue segmentation processing on the two-dimensional image; adopting an off-line parameterization method for the separated soft tissue part, and reconstructing a soft tissue three-dimensional model by setting deformation parameters and based on iterative optimization of segmented fusion; and mapping the texture information of the two-dimensional image to the three-dimensional model, and optimizing and screening the texture information through a probability graph to complete the three-dimensional model texture mapping of the oral soft tissue. Through a differentiated and efficient data processing method, rapid and accurate oral cavity three-dimensional model reconstruction and texture mapping are realized.

A method of additive manufacturing an object featuring properties of a hard bodily tissue, comprises: dispensing and solidifying a plurality of non-biological material formulations to sequentially form a plurality of hardened layers in a configured pattern corresponding to a shape of the object. The method forms voxel elements containing different material formulations at interlaced locations to provide a three-dimensional textured region spanning over the portion. The material formulations and the interlaced locations are selected such that the textured region exhibits, once hardened, a stress variation of at most ±20% over a strain range of from about 0.1% to about 0.3%.

The invention discloses an orthodontic micro-implant nail implanting method, device and system and a storage medium. The method comprises the following steps: S1, acquiring CBCT three-dimensional data; and S2, analyzing CBCT three-dimensional data through AI artificial intelligence to calculate an optimal implantation site and an implantation direction path, and designing an implantation guide plate mounted on the surface of the dental crown. By the adoption of the technical scheme, the success rate of implanting the micro-implant nail is increased, relevant soft and hard tissue indexes in the CBCT three-dimensional image are integrated, and the burden and judgment errors of an orthodontic doctor in measurement and positioning are reduced.

The present invention is concerned with a manufactured article prepared from a biomaterial comprising isolated and purified type I collagen fibrils derived from abalone and a method of preparing such an article. The manufactured article can be prepared by 3D bioprinting, and therefore the present invention also envisages a novel bioink for a 3D bioprinter comprising an isolated and purified type I collagen fibril and cartridges containing such a bioink. The invention additionally relates to a method of isolating type I collagen fibrils from abalone. The manufactured article is useful in a number of biomedical applications including as an implantable device where it can function as a 3D bioprinted hard or soft tissue scaffold for tissue engineering.

The invention provides a laser oral cavity therapeutic instrument which comprises a therapeutic instrument body, a laser generation assembly, a water vapor nozzle assembly and a gas-liquid-electricity external connection assembly, the laser generation assembly, the water vapor nozzle assembly and the gas-liquid-electricity external connection assembly are arranged in the therapeutic instrument body, and the laser generation assembly is used for generating a high-energy laser beam; the oral cavity treatment is performed through the high-energy laser beam; the water vapor spray head assembly is used for forming water vapor spray so as to cooperatively clean or cool the oral cavity; the gas-liquid-electricity external connection assembly is used for connecting external gas, water and electric signals so as to ensure normal work of the laser oral cavity therapeutic instrument. The laser generating assembly, the steam spray head assembly and the gas-liquid-electric external connection assembly are arranged in the therapeutic instrument body, the laser generating and emitting function and the steam mixing and cooling function are integrated into one structure, the operation requirements of basic decontamination and sterilization, soft and hard tissue cutting, bone tissue removal and the like are met, and meanwhile the therapeutic instrument has the advantages of being high in integration degree, reasonable in structure, convenient to operate and the like.

The invention discloses an orthodontic visualization system and method for temporomandibular joint rotation simulation, and relates to the technical field of orthodontic medical treatment, and the system comprises a hard tissue extraction module which automatically extracts hard tissue image data from a patient skull CBCT image; the joint recognition control module recognizes anatomical features of the condyle process and the glenoid fossa and generates optimized condyle process rotation parameters; the jaw rotation control module dynamically optimizes a lower jaw rotation angle based on first-order and second-order change rates in the contact pressure distribution model; the tooth image intelligent virtual module is used for identifying a tooth form outline, simulating a tooth embedding or separating state and quantifying a vertical displacement amount of the tooth; the microprocessor integrates data of each module to generate dynamic image data; the visual terminal module dynamically displays a condylar process rotation track, contact pressure distribution and a tooth displacement state, and marks high-pressure and low-pressure areas through colors. According to the method, the accuracy and efficiency of orthodontic scheme design are improved, and the method has important clinical application value.

The application relates to the technical field of oral cavity diagnosis, in particular to an oral cavity diagnosis method for establishing an oral cavity diagnosis neural network model, which comprises the following steps: collecting oral cavity CT, endoscope hard tissue three-dimensional coordinates, soft tissue color parameters, tooth surface texture gray value parameters, checking and removing abnormal values to generate an oral cavity standardized original data set, extracting features and assigning weights to generate a weighted signal set, iteratively training to obtain diagnosis network weight parameters, calculating lesion matching degrees, dividing grades to establish oral cavity lesion quantitative grading data, in the application, oral cavity hard tissue three-dimensional coordinates, soft tissue color parameters and tooth surface texture gray value parameters are collected, values exceeding the normal physiological range are checked and removed to generate a standardized data set, features are extracted, converted into discrete signals and assigned with degree of distinction weights, stable diagnosis criteria are established through hierarchical transmission calculation and iterative training, accurate positioning and quantitative grading of oral cavity lesions are realized, and the diagnosis precision, efficiency and result consistency are greatly improved.

There is provided a kit for performing socket shield technique, and methods for using the kit, wherein the kit may include a wheel bur, having a first working surface disc and a second working surface disc configured to smoothen and cut hard tissues of a tooth; one or more trephine burs with stoppers configured to cut a root canal to create a first tooth fragment and a second tooth fragment, wherein each stopper is compatible with each of the one or more trephine burs; a root fragment remover configured to extract the first tooth fragment and stabilize the second tooth fragment; a split end elevator having a v-shaped notch tip configured to remove the first tooth fragment; a cylindrical bur to control the thickness of the second root fragment; and a round bur configured to separate the second root fragment from unwanted fragments.

The invention discloses a preparation method of a Schottky composite material, a coating, an antibacterial stent and application, and belongs to the field of biological materials. According to the preparation method, Pdene of a two-dimensional structure is prepared through a wet chemical reduction method, then bismuth oxychloride (BiOCl) nanoflowers are grown on metal alkene (Pdene) in situ through an electrostatic adsorption mode, the obtained schottky composite material can regulate and control interface charge redistribution, the adsorption energy of reaction intermediate products is optimized, meanwhile, the piezoelectric property of BiOCl is enhanced, and the performance of the schottky composite material is improved. Bacterial oxidative stress can be effectively promoted, bacterial energy metabolism is interfered, finally, efficient removal of bacteria is achieved, and hard tissue repair is promoted.

This invention provides a method and apparatus for 3D tooth reconstruction based on multi-view geometric priors and specular Gaussian representation. The method first acquires multi-view image data containing teeth and gingiva. A multi-view geometric estimation module predicts and globally aligns dense 3D point maps to obtain an initial point cloud, camera intrinsic and extrinsic parameters, and a depth map. Based on this, a Gaussian primitive set is initialized and input into a specular Gaussian reconstruction module, where relevant parameters are combined to optimize the reconstruction. This module introduces depth and normal losses based on the color target, supervises and reduces the weight of highlight regions within the region of interest, and finally outputs the 3D reconstruction result. This invention can improve the stability and geometric accuracy of tooth reconstruction under high reflectivity and weak texture, enhance specular reflection and highlight expression capabilities, and balance the detailed reconstruction of tooth hard tissue with the geometric and appearance effects of gingival soft tissue, thereby improving the integrity of oral scene reconstruction and its clinical application value.

The utility model belongs to the technical field of animal waste, and particularly relates to an animal waste harmless treatment system which comprises a frame, a drying device is arranged on the outer surface of the frame, the drying device comprises an electric heating wire, the electric heating wire is started to dry the waste, and a grinding device is arranged to grind the waste so as to grind the waste. The grinding motor drives the rotating rod to rotate, the rotating rod is rotationally connected with the grinding roller, rotation of the grinding roller is not affected while the grinding roller is driven to revolve, and the rotating gear fixedly installed on the grinding roller is meshed with the gear ring fixedly installed on the grinding frame to enable the grinding roller to rotate, so that the waste grinding efficiency can be improved, and the problems that in the prior art, bones are hard tissues, and the grinding efficiency is poor are solved. Large bone blocks and skeletons need to be completely degraded or decomposed for a long time, and the overall waste treatment efficiency is remarkably affected.

The invention discloses a novel dental turbine handpiece. Comprising a shell, a bur, a wheel disc, a turbine and a main shaft, a positioning shaft penetrates through the upper portion of the wheel disc and is arranged in the front-back direction, a machine needle is coaxially arranged at the front end of the positioning shaft and detachably connected with the positioning shaft, and the rear end of the positioning shaft is connected with the shell through a bearing. A square groove penetrates through the lower part of the wheel disc; the main shaft is arranged in the front-back direction, the turbine and the eccentric wheel are sequentially sleeved outside the main shaft in the axial direction, the eccentric wheel is located in the square groove and connected with the main shaft, a center hole of the turbine is connected with the main shaft, and the two ends of the main shaft are connected with the shell through bearings. According to the invention, hard tissue of teeth is cut while soft tissue of oral mucosa is prevented from being damaged, any surface of the machine needle can be used for working, the utilization rate of the cutter teeth on the machine needle is increased, and the service life of the machine needle is prolonged.

The invention provides a porous biological ceramic hard tissue slice as well as a preparation method and application thereof. The preparation method of the porous biological ceramic hard tissue slice comprises the following steps: preparing a hydroxyl phospholime bone restoration specimen; dehydrating and transparentizing the hydroxyapatite bone restoration specimen; carrying out permeation and embedding on the hydroxyl phospholime bone restoration specimen; carrying out block trimming and slicing on the hydroxyl phospholime bone restoration specimen; mounting the hydroxyl phospholime bone restoration specimen; through the five steps, the porous biological ceramic hard tissue slice is obtained. According to the method, the defect that a tissue-material structure is easy to damage when a biological ceramic material is treated by a traditional hard tissue slicing technology is overcome; the improved hard tissue slicing technology is suitable for research of biological ceramic materials in bone tissue engineering application.

A device for mechanical securement to hard tissue of a subject, the hard tissue having an end surface defining a direction of curvature such that over at least a portion of the surface, a total curvature of at least 180 degrees is defined, the device comprising a body portion comprising at least four contact points, three contact points of the four contact point span over 180 degrees of total curvature of the end surface in a plane defined by the three contact points, and a fourth contact point outside the plane, the four contact points providing mechanical securement of the body portion to the hard tissue.

The present invention provides a method for repairing craniofacial hard tissue loss based on a universal repair model, which relates to the technical field of mandibular defect reconstruction. The method utilizes a plug-and-play conditional attention mechanism and a curvature-aware query generator to construct a universal craniofacial hard tissue repair model. Point cloud data of craniofacial hard tissue is input into the universal craniofacial hard tissue repair model and trained using a weighted loss function to obtain a trained universal craniofacial hard tissue repair model. Denoising is performed on the missing repair point cloud features to obtain denoised missing repair point cloud features. Point cloud meshing is performed using the denoised missing repair point cloud features to obtain a craniofacial hard tissue loss repair result, thereby completing the repair of craniofacial hard tissue loss. The present invention solves the problem of the difficulty in uniformly addressing hard tissue repair and reconstruction in the skull.

The invention discloses a periodontal complex stent with a bionic structure and a preparation method. The preparation method comprises the following steps: step 1, preparing a polycaprolactone-polylactic acid nanofiber membrane by an electrostatic spinning method; 2, the polycaprolactone-polylactic acid nanofiber membrane obtained in the step 1 is coated with chitosan layer by layer, the fiber membrane is stacked, and after freeze drying, a polycaprolactone-polylactic acid nanofiber scaffold is obtained; 3, immersing the polycaprolactone-polylactic acid nanofiber scaffold obtained in the step 2 into a collagen solution, and carrying out self-assembly to form a composite scaffold; then immersing into a hydroxyapatite solution, and mineralizing to obtain the required composite scaffold; according to the invention, a directionally arranged PCL-PLA nanofiber scaffold is taken as a basis, the surface layer is coated with porous collagen, and after mineralization, a mineralized structure with gradient decreasing from a collagen layer in an external phase to a middle fiber layer is obtained; the obtained composite scaffold simulates a heterogeneous structure of periodontal membrane-bone interface tissue, and provides possibility for collaborative regeneration of soft and hard tissues of a periodontal complex.

The invention discloses a dismounting and mounting structure and a repeatable loading clamp device, and belongs to the technical field of medical instruments. The dismounting and mounting structure comprises a clamp seat and a conveying seat which are detachably connected; the conveying seat is connected with a sheath tube of the conveying device, a moving channel is arranged in the conveying seat, an inner core is arranged in the moving channel, the near end of the inner core is connected with an inhaul cable, and a connecting plug is arranged at the far end of the inner core and comprises an expansion section and a necking section; a mounting channel is formed in the clamp seat, a connecting pull piece is arranged in the mounting channel, the far end of the connecting pull piece is connected with the hemostatic clamping piece, an insertion opening is formed in the near end of the connecting pull piece, a mounting area, a limiting area and a releasing area are arranged in the mounting channel, the mounting area and the releasing area allow the insertion opening to be opened in the radial direction for the expansion section to pass through, and the limiting area is used for limiting the insertion opening; the repeatable loading clip device comprises a hemostatic clip piece, a conveying device and a disassembly and assembly structure. In different positions, the clamp can be quickly mounted and released, and the hemostatic clamping piece can reliably clamp and close tissues with larger wounds, harder tissues and scabbed tissues.