43 results about "Skin lesion" patented technology

This invention relates to a vulnerary multifunctional composition, based on unripe coffee cherries (peel, mucilage, beans and silverskin), seed extract of Trigonella foenum-graecum, with one or more tissue-inducing molecules derived from the secondary metabolites of both plants. The unexpected and surprising ability of this new composition to solve the problems of chronic non-healing wounds addresses a long felt unmet need in the medical arts. Through a multifaceted approach, it combats microbial infections, reduces chronic inflammation, counters oxidative stress, enhances immune responses, promotes angiogenesis, regulates protease activity, stimulates collagen deposition, increases growth factor availability, facilitates cell migration, and prevents persistent infections. These novel integrated therapies represent a breakthrough in addressing macroscopic wound healing while targeting the underlying microscale mechanisms. This invention also relates to methods for preparing, using, and administering the multifunctional composition for timely healing in mammals with various skin lesions.

This invention relates to a phototherapy device for skin diseases, comprising a base unit, several adjustment units, several mounting units, several phototherapy units, and several covering units. Its advantages include: the base unit provides a mounting foundation, allowing for placement in homes or community medical institutions, overcoming the location limitations of whole-body phototherapy devices that can only be used in specific hospital departments; the sliding cooperation between the adjustment units and the base unit enables the horizontal reciprocating movement of the mounting units, allowing adjustment of the phototherapy unit's position according to the patient's needs; and the detachable connection between the phototherapy units and the mounting units facilitates the replacement of phototherapy units of different sizes according to the area of ​​skin lesions. Patients can complete treatment independently at home without frequent trips to the hospital, reducing time costs and the burden of treatment cycles. It also avoids the embarrassment of full-body exposure in public places like hospitals, alleviating situations where patients interrupt treatment due to privacy concerns.

This invention provides a skin condition detection method and system based on image recognition. The method includes acquiring a skin image to be analyzed and related textual metadata; inputting the preprocessed image into a trained skin lesion segmentation model and outputting the segmentation result of the lesion region; automatically extracting the size information and at least one morphological quantitative feature of the skin lesion based on the segmentation result, and integrating the size information and the morphological quantitative feature as supplementary features into the textual metadata to form enhanced metadata; assigning appropriate weights to the image features and the textual features based on the mutual information between the image features and the textual features, and dynamically weighting and concatenating them to form a fused feature vector; inputting the fused feature vector into a classifier and outputting the classification result of the skin condition, which significantly improves the model's ability to distinguish similar skin diseases, especially early malignant lesions, and improves the classification accuracy.

The application belongs to the technical field of medical image processing, and particularly relates to a human limb skin disease area evaluation method, device and system. The method comprises the following steps: collecting multi-view images of a target limb, adjacent view angles of the multi-view images containing overlapping areas; generating a three-dimensional point cloud of the target limb based on the multi-view images; constructing a cylindrical model with a radius changing along a limb axis based on the three-dimensional point cloud; projecting the multi-view images to the cylindrical model, and selecting pixels projected to the same position of the model based on an evaluation function, so that the model surface is attached with image texture; and unfolding the cylindrical model with the texture into a two-dimensional plane image for evaluating the skin disease area. The application realizes high-precision and high-fidelity lesion area evaluation without expensive three-dimensional scanning equipment.

This invention discloses a medical image segmentation method based on enhanced attention. The method acquires a medical image, preprocesses it, and inputs it into an encoder to output a multi-scale feature map of the medical image. The encoder includes N cascaded multi-dimensional attention modules. Each multi-dimensional attention module extracts multi-scale features through dual-channel convolution and residual connections, and performs feature recalibration using an attention enhancement module. The output multi-scale feature map is then fused by a multi-scale dilated fusion attention module to obtain the feature map output by the encoder. The feature map output by the encoder is input to the decoder, where it is combined with high-resolution feature maps of the corresponding levels passed from the encoder via skip connections. Through progressive upsampling and feature fusion, a reconstructed feature map is obtained. The reconstructed feature map output by the decoder is used to generate a medical image segmentation mask through 1×1 convolution and a sigmoid activation function to complete the segmentation of diseased tissues. This invention significantly improves the boundary segmentation accuracy for knee joints, breast tumors, and skin lesions.

The application belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine compound preparation for treating anal eczema as well as a preparation method and application thereof. The traditional Chinese medicine compound preparation is prepared from the following raw medicinal materials in parts by weight: 35-45 parts of Sophora flavescens, 35-45 parts of Cnidium monnieri, 18-22 parts of Semen Astragali Complanati, 18-22 parts of Cortex Dictamni, 18-22 parts of Scutellaria baicalensis, 118-22 parts of Phellodendri, 10-14 parts of Chuanxiong Rhizoma, 16-20 parts of Angelica sinensis, 10-14 parts of Radix Paeoniae Alba, 16-20 parts of Saposhnikovia divaricata, and 10-14 parts of Gleditsia sinensis. The application provides a traditional Chinese medicine compound preparation and a Chinese medicine treatment method for treating acute and chronic anal eczema caused by 'damp-heat invasion'. The traditional Chinese medicine compound preparation can not only significantly relieve the perianal pruritus and exudation of the patients with anal eczema, but also effectively reduce the skin lesion area and improve the skin lesion state, and the clinical curative effect is obvious. In addition, the raw materials of the traditional Chinese medicine compound preparation are widely sourced and low in price, the pure traditional Chinese medicine raw materials are used for processing, and the preparation process is simple.

This invention relates to the fields of biomedicine and nanomaterials, specifically to a curcumin-containing metal-organic framework nanocomposite material, its preparation method, and its applications. The metal-organic framework nanocomposite material uses the metal-organic framework MIL-101(Cr) as a substrate and introduces Ag... + As a functional component and Cr 3+ A bimetallic node is formed, and curcumin, as an active functional ingredient, is encapsulated within the pores of MIL-101(Cr) and / or modified on its surface, forming a carrier-bimetallic-functional ingredient composite structure. This composite material exhibits excellent performance and good biocompatibility. The preparation method is simple and highly controllable, making it suitable for industrial production. Furthermore, it expands the application scenarios of this composite material, providing new solutions for the treatment of clinical bacterial infections and the repair of skin lesions.

The application discloses a skin disease diagnosis and treatment scheme generation method and a generation system. The generation method comprises the following steps: acquiring a plurality of skin lesion images and medical record text content of a patient; determining the overall skin lesion condition and pathogenesis of the patient based on the acquired plurality of skin lesion images and in combination with a skin disease representation model, wherein the skin disease representation model is constructed based on a general multi-modal large model; determining the diagnosis condition and treatment scheme of the skin disease based on the acquired plurality of skin lesion images and medical record text content, the determined overall skin lesion condition and pathogenesis, and in combination with a skin disease reasoning model, so as to generate the diagnosis and treatment scheme of the skin disease, wherein the skin disease reasoning model is constructed based on the skin disease representation model. In this way, the diagnosis and treatment process of the skin disease is simplified, and the diagnosis and treatment efficiency is improved.

This invention relates to polypeptides and their applications in repairing mucosal or skin damage. The polypeptides of this invention are not homologous to known polypeptides and can exist stably both in vivo and in vitro, and have the effect of regulating stem cell proliferation and differentiation to repair mucosal or skin damage; as well as the use of the novel polypeptides in repairing mucosal or skin damage by regulating stem cell proliferation and differentiation, and their use in preventing, alleviating or treating gastrointestinal diseases.

This invention relates to the field of medical materials technology, providing a hydrogel containing antler mesenchymal stem cell exosomes, its preparation method, and applications. The method includes the following steps: preparation of antler mesenchymal stem cell exosomes; preparation of PVP-HA composite hydrogel; uniformly mixing AMSC-Exos with a hydrogel precursor solution, and forming a hydrogel containing antler mesenchymal stem cell exosomes through physical embedding and non-covalent interactions. This invention utilizes the three-dimensional porous network structure of the hydrogel to achieve long-term sustained release of exosomes, protecting them from rapid degradation; it leverages the unique regenerative advantages of antler-derived exosomes to synergistically promote angiogenesis, inhibit inflammatory responses, and regulate macrophage polarization; it promotes angiogenesis through the miR-486-5p / FGF9 axis, achieving efficient repair of chronic diabetic wounds; and it provides a novel, efficient, safe, and clinically translational strategy for the treatment of chronic diabetic skin lesions.

The application belongs to the technical field of biological medicine, and particularly relates to a binding molecule targeting CCL5 and application of the binding molecule in combination with drugs in treatment of Th2-type inflammation related diseases. The application discloses use of a binding molecule targeting CCL5 or a pharmaceutical composition comprising the binding molecule in preparation of a product having one or more of the following functions: 1) prevention and / or treatment of Th2-type inflammation related diseases; 2) reduction of skin lesion tissue thickness; 3) reduction of clinical score of atopic dermatitis; 4) reduction of scratching behavior; 5) reduction of tissue damage; 6) alleviation of inflammatory reaction and inhibition of expression of inflammatory factors; and 7) reduction of inflammatory cell infiltration. The binding molecule targeting CCL5 or the pharmaceutical composition comprising the binding molecule has important value in prevention and treatment of immune inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma, food allergy or drug allergy.

The application relates to a compound traditional Chinese medicine composition for treating dermatitis of tumor patients, which is prepared from the following raw materials in parts by weight: 20-40 parts by weight of Huangqi, 5-15 parts by weight of Wumei, 5-15 parts by weight of Baishao, 5-15 parts by weight of Dilong and 10-20 parts by weight of Danshen, and a preparation method thereof is disclosed. The application can obviously improve the clinical dermatitis score related to skin lesions, reduce the spleen coefficient index, and also has the functions of reducing the epidermal thickness and inflammatory infiltration such as mast cells in the dermis, and reducing the inflammatory factor level in the skin lesions, which shows that the application can treat dermatitis of tumor patients.

The present application relates to traditional Chinese medicine composition and its application in the field of skin inflammation diseases, and discloses a kind of drug composition for treating skin inflammation and its preparation method and application.The composition is prepared from white fungus, tribulus terrestris, smilax glabra, kochia scoparia, honeysuckle, baishiy, rehmannia glutinosa, oak, peony, radix lithospermi, periostracum cicadae, licorice, gardenia and sophora flavescens.The UPLC-Q-TOF-MS identification contains 110 kinds of components;Animal experiments show that it can significantly reduce psoriasis skin lesions, down-regulate TNF-alpha, IL-1beta and IL-6, up-regulate IL-10, and inhibit PI3K-Akt pathway.The present application has clear components, clear mechanism and definite curative effect, and can be used for preparing medicine for treating psoriasis, chronic urticaria and senile pruritus.

This invention provides a hydrogel for treating atopic dermatitis and its applications, relating to the field of biomedical technology. The hydrogel comprises SA, plasma water, L-G2, and / or FLA. Preliminary evaluation of the hydrogel was conducted through in vitro cytotoxicity and antibacterial performance tests, confirming its ability to inhibit Staphylococcus aureus and Escherichia coli. Simultaneously, the hydrogel exhibits low cytotoxicity, meeting the basic requirements for biomedical dressings. In animal experiments, by comparing skin lesions before and after treatment in AD mice, the hydrogel was observed to significantly improve skin lesions on the back of mice, demonstrating good anti-inflammatory effects. Pathological histological analysis showed that the hydrogel can reduce epidermal thickness, inhibit the increase in TNF-α levels induced by DNCB, and promote inflammation relief. Simultaneously, SA can provide a moist healing environment for skin wounds, helping to promote wound repair. Therefore, this hydrogel provides a new strategy for the treatment and management of AD and is expected to become a novel topical drug for AD treatment.

The present application belongs to the field of image feature analysis, and specifically refers to a skin image feature analysis method based on a reflective confocal microscope, which comprises distortion correction, image preprocessing and global perception. Through GPU accelerated lookup table encoding and decoding technology, the efficiency of distortion correction is significantly improved, the number of memory access is reduced, real-time and efficient image processing is realized, the quality of the skin medical image is improved in combination with medical imaging technology, which has great significance for clinical application; in combination with feature extraction, matching and global optimization technology, a high-precision global skin image is obtained and updated, effectively solving the geometric distortion problem caused by probe jitter or inter-frame alignment error, and being able to adapt to the instability of artificial handheld operation, generating a global skin image in single-point imaging of a shaking skin lesion position, and ensuring the continuity and consistency of image acquisition.

The application provides a medical image segmentation method based on a polar fine-tuning large model migration method, and solves the technical problem that when a large model is migrated from a natural image to a more complex medical image task, a traditional fine-tuning strategy has discrete fitting effects and cannot fully capture potential complex features in data when facing high-dimensional input and complex images. The method comprises the following steps: S1, rotating an image of a skin lesion with a center point to form a new picture; S2, using a polar fine-tuning strategy to inject self-attention in a decoder and feed-forward MLP in parallel with a low-rank branch; S3, inputting decoupled features and prompt flow features into the decoder; S4, inputting the decoupled features and the prompt flow features into the decoder to output a predicted mask image; and S5, building a large model migration learning deep learning network PoSAM based on the polar fine-tuning strategy. The application performs decoupled correction on features, and quickly aligns the offset without damaging the original representation structure.

The application discloses a preparation method and application of peach gum polysaccharide fermentation product based on infant bacteria, and belongs to the technical field of biotechnology. The preparation method comprises the following steps: S1, after washing the peach gum, the peach gum is soaked in water and mixed with infant bacillus powder for fermentation; S2, after the fermentation is completed, the material liquid is subjected to high-speed centrifugation, the supernatant is taken, and alcohol precipitation is carried out after microfiltration; S3, the precipitate is washed by deionized water, then is subjected to suction filtration, and the peach gum polysaccharide fermentation product is obtained by freeze-drying. The infant bacillus has a preservation number of CGMCC NO. 32402. The peach gum polysaccharide fermentation product is prepared by using infant bacillus, and a composition is prepared based on the peach gum polysaccharide fermentation product; the composition has excellent anti-allergic itching, anti-inflammatory, antioxidant, skin moisturizing, skin lesion repairing and transdermal properties. The composition solves the problem of poor transdermal property and absorbability caused by the high cross-linking of the peach gum in the prior art, and has the potential of preparing anti-allergic, anti-inflammatory and moisturizing cosmetics.

This invention belongs to the field of computer vision technology, specifically relating to a skin lesion image segmentation method based on a Transformer dual-branch model. The method constructs and trains a Transformer dual-branch model, inputting the image to be processed into the trained Transformer dual-branch model to obtain the segmentation result. The Transformer dual-branch model includes a main branch network, an auxiliary branch network, and an information aggregation module. This invention proposes a novel skin lesion image segmentation method that addresses the shortcomings of traditional deep learning methods in extracting global contextual information. It utilizes an efficient multi-scale visual Transformer as an encoder to extract more powerful and robust features. Simultaneously, it introduces low-level feature modules and high-level feature fusion modules to effectively improve the network's feature learning ability and segmentation performance.

The present application belongs to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition and application thereof. The present application takes the core principle of 'nourishing blood and activating blood, inhibiting estrogen and removing spots' as the core principle, is based on traditional Chinese medicine internal regulation and treatment of the root, and inhibits the formation of chloasma from the root by regulating estrogen balance. The traditional Chinese medicine composition is composed of eight medicines including Evodia rutaecarpa, cornu cervi, Angelica sinensis, Ligusticum chuanxiong, Radix Rehmanniae Preparata, Radix Paeoniae Alba and honeycomb, can significantly fade the skin lesions and reduce the recurrence rate, is safe, non-toxic, has long-lasting efficacy, and has outstanding clinical advantages. The present application is superior to the commonly used western medicine when used alone, and can synergistically enhance the efficacy when combined with the western medicine, and provides a new Chinese medicine selection for the treatment of chloasma.

This invention relates to the field of Mongolian medicine technology and discloses a Mongolian medicine composition for treating skin diseases caused by damp-heat and toxin accumulation. It aims to address the problem that existing technologies struggle to balance the efficacy of skin lesion treatment with the safety of systemic medication when treating patients with damp-heat and toxin accumulation skin diseases complicated by chronic diseases such as hypertension and asthma. This invention limits the specific weight ratio range between the heat-clearing and blood-cooling herbs and the harmonizing and strengthening herbs in the composition, and optimizes the synergistic relationship between the principal herbs and other adjuvant herbs. Under specific proportions, the composition maintains its basic effects of clearing heat and detoxifying, removing dampness and cooling blood, while enhancing its ability to clear damp-heat and toxins from the local skin. Furthermore, through the mutual restraint of the internal compatibility, it reduces potential interference with the patient's cardiovascular and respiratory systems. Therefore, this invention provides a new Mongolian medicine preparation that can safely and effectively treat skin diseases caused by damp-heat and toxin accumulation, especially suitable for patients with related chronic underlying diseases.

This utility model relates to a novel Wood's lamp, comprising a handle, a connecting rod, a mounting box, a connecting plate, a lamp source assembly, and an external light-shielding assembly. The mounting base of the lamp source assembly has a conical outward-expanding lamp cavity and a ring-shaped camera array. The light-shielding cover of the external light-shielding assembly adopts a split magnetic suction structure, and its elastic layer is a waveform silicone integrated pressure sensor to achieve dynamic sealing and trigger the light source. The mounting box has a built-in AI processor and an anti-interference heat dissipation system. This utility model overcomes the limitations of darkroom environments, achieving accurate detection of skin lesions under sunlight through the synergy of physical light shielding and electronic light filtering, and is particularly suitable for imaging curved surfaces without blind spots.

Disclosed is an ultrasonic diagnostic apparatus including a probe configured to transmit an ultrasonic signal to an object and receive information about an echo signal reflected from the object, and a main body including a display, an input interface configured to receive user input, and a processor configured to obtain physical examination data about a sacrum skin lesion of the object from the input interface, obtain an ultrasonic image of the object based on the information about the echo signal obtained from the probe, detect a variation related to a sacral dimple on the ultrasonic image, classify the variation as any one of a normal variation and a pathological finding, and control the display to display information about the pathological finding on the ultrasonic image based on the variation being classified as the pathological finding.

A composition usable for removing biofilm and necrotic or infected tissue from a skin lesion, comprising ethanesulfonic acid or 1-propanesulfonic acid and a proton acceptor. The proton acceptor is selected from the group consisting of dimethyl sulfoxide, silicon dioxide, tetraethoxysilane, and mixtures thereof. This composition can be prepared in gel form.

The present application relates to the technical field of medical apparatus and instruments, and discloses a dermato logical superficial skin lesion cleaning electrotome, which comprises an electrotome body, a supporting mechanism is arranged on the electrotome body, the supporting mechanism comprises a movable cylinder, an outer cylinder, an elastic sleeve and three support frames which are in contact with the skin, the movable cylinder is arranged on the electrotome body, the outer cylinder is arranged on the outer side of the movable cylinder, the elastic sleeve is fixedly installed between the movable cylinder and the outer cylinder, the three support frames are annularly and equidistantly rotationally installed on the outer cylinder, a rotating block is rotationally installed at the end of the support frame away from the outer cylinder, and a magnifying glass is fixedly installed on the support frame. The purpose is to solve the problem that when the high-frequency electrotome is used, the doctor needs to hold the electrotome pen to clean the lesion of the patient, but when the micro-lesion is treated, slight shaking of the hand will affect the movement of the pen head of the electrotome pen, thereby causing the burning of the skin of the patient, and therefore the operation requirement of the doctor is relatively high.

The present application relates to the technical field of medicine and daily chemical products, and discloses a composition, a product containing the same, a preparation method of the composition, and application of the composition.The composition comprises 0.8-1.2 parts of zinc pyrithione, 0.5-0.8 parts of salicylic acid, 0.1-0.2 parts of farnesol, 0.2-0.4 parts of gentiana scabra extract, 0.3-0.5 parts of portulaca oleracea extract, 0.5-1.0 parts of camellia sinensis seed cake extract, 0.1-0.3 parts of caffeine, and 0.3-0.5 parts of rosemary extract, in terms of mass fraction.The composition realizes improvement in aspects of skin lesion area, water content in the scalp stratum corneum, trans-epidermal water loss, oil secretion, high-temperature stability, centrifugal stability, freeze-thaw cycle stability, dandruff removal, anti-inflammatory effect, hair fixing, and / or anti-itching effect.

Compounds can specifically activate TLR7. The compounds are useful because they can stimulate innate immunity. The compounds can be used in the treatment of conditions including cancer, viral infections and skin lesions. The compounds can optionally be formulated for enhanced penetration following topical administration, the composition preferably initiating a local specific inflammatory cytokine response while limiting undesirable erythema and other inflammatory reactions. Pharmaceutical compositions contain the compound and preferably an additional compound such as imiquimod and / or resiquimod (R848). A composition contains the compound and a compound can be used as a medicament. Other aspects, embodiments, advantages and applications will become clear from the further description herein.

The present application relates to the application of platynecine in the preparation of drugs for preventing and / or treating skin lesions or tumors. The present application first discovers and verifies the direct inhibitory effect of platynecine on GNAQ mutant protein by constructing a "phenotype-function-target" three-in-one hierarchical screening system, and confirms its broad application prospect in treating diseases mediated by abnormal activation of GNAQ, GNA11 or GNA14 or mutation of related sites. The present application finds that platynecine can be used as a direct inhibitor of GNAQ mutant protein, which breaks the long-standing situation of lack of small molecule direct inhibitors for this target. Through SPR (physical binding) and IP1 (functional blocking) double experimental evidences, it is proved that platynecine is a direct inhibitor of GNAQ, not a broad-spectrum cytotoxic compound. Since the molecular weight of platynecine is moderate (464.6 Da), it is easy to be chemically modified and mass-produced; it has the potential to develop transdermal preparations for external use, providing a new direction for drug treatment of skin diseases such as PWS, to replace or supplement the existing laser therapy.

The present invention provides brachytherapy radiation delivery device designed to topically treat cutaneous skin lesions in patient tissue. The topical radiation delivery device includes a layer of one or more radionuclides. The topical radiation delivery device includes a high Z top shielding layer placed adjacent the side of the radionuclide layer away from the patient tissue. The top shielding layer attenuating the energy of the radionuclide from the environment external to the patient. The patch further includes a bolus layer placed between the patient tissue and the radionuclide layer which attenuates the beta radiation fluence. The one or more radionuclides of the brachytherapy radiation delivery device producing a gamma and beta radiation fluence to achieve a desired Percent Depth Dose within the cutaneous skin lesion.

The present application relates to the technical field of computer vision and medical image processing, and discloses a facial acne intelligent grading method and system based on image analysis, which comprises the following steps: facial image standardization acquisition and skin color normalization preprocessing, facial key point positioning and region of interest analysis, multi-type acne lesion instance segmentation and automatic counting, region weighted multi-feature fusion lesion severity comprehensive score, acne grade determination based on clinical grading standard, and image registration before and after treatment and curative effect quantitative evaluation. The present application eliminates the differences in illumination and skin color through skin color normalization, realizes fine identification of five types of skin lesions including comedones, papules, pustules, nodules and cysts, and outputs corresponding clinical grading results and curative effect evaluation report by combining region weight and category weight to calculate comprehensive score.