79 results about "Skin damage" patented technology

The application provides a drying method of Chuanxiong medicinal material and application of Chuanxiong or its extract in preparation of an external medicine for treating atopic dermatitis. The drying method of Chuanxiong medicinal material improves Chuanxiong processing efficiency, shortens processing period, obtains by-product Chuanxiong extract in addition to preparation of decoction pieces, reduces energy consumption and lowers production cost. The Chuanxiong essential oil and Chuanxiong extract are both composed of small molecule components, have good affinity to skin, are absorbed through skin quickly, can quickly relieve symptoms such as itching and skin damage caused by atopic dermatitis, and are natural, safe and free of side effects. Meanwhile, the small molecule components contained in the Chuanxiong essential oil and Chuanxiong extract have good lipophilicity, have softening effect on the thickened stratum corneum caused by atopic dermatitis, and are more conducive to drug absorption. In addition, the Chuanxiong essential oil and Chuanxiong extract are simple to prepare and low in price.

This invention discloses a composition with whitening and freckle-removing effects, its preparation method, and its application, belonging to the field of composition technology. The composition provided by this invention reduces the body's oxidative stress level, providing a suitable internal microenvironment for the efficacy of various drugs and the repair of damage; it provides a sufficient, diverse, and easily absorbed material basis for skin damage repair; it significantly improves the whitening and freckle-removing effect by increasing the activity, purity, and content of the components that directly have whitening and freckle-removing effects; and it promotes the excretion of metabolic waste by improving gastrointestinal health. It is extremely safe, requires minimal equipment, and is environmentally friendly, making it suitable for daily skin repair and whitening / freckle-removing edible use.

This invention discloses the application of homoserine as a barrier repair factor in the preparation of skin repair compositions. As a multidimensional regulator of skin barrier function, homoserine systemically integrates post-sun exposure damage repair, physical barrier repair, and microecological barrier repair, providing a multi-target synergistic mechanism to effectively repair the skin barrier and alleviate skin damage. The application of homoserine in cosmetics or skin care products meets consumers' needs for precise skin repair.

This invention relates to a vulnerary multifunctional composition, based on unripe coffee cherries (peel, mucilage, beans and silverskin), seed extract of Trigonella foenum-graecum, with one or more tissue-inducing molecules derived from the secondary metabolites of both plants. The unexpected and surprising ability of this new composition to solve the problems of chronic non-healing wounds addresses a long felt unmet need in the medical arts. Through a multifaceted approach, it combats microbial infections, reduces chronic inflammation, counters oxidative stress, enhances immune responses, promotes angiogenesis, regulates protease activity, stimulates collagen deposition, increases growth factor availability, facilitates cell migration, and prevents persistent infections. These novel integrated therapies represent a breakthrough in addressing macroscopic wound healing while targeting the underlying microscale mechanisms. This invention also relates to methods for preparing, using, and administering the multifunctional composition for timely healing in mammals with various skin lesions.

To provide a method for treating a disease. [Solution] The present invention relates to compounds, compositions and methods for modulating skin pigmentation in a subject, and for treating or preventing UV-induced skin damage, erythema, skin aging, sunburn and hyperpigmentation. The compounds, compositions and methods of the present invention generally include compounds derived from Malassezia, including malassezin and indirubin, and / or their chemical analogues. Other uses of the compounds and compositions disclosed herein include, but are not limited to, improvement of hyperpigmentation caused by hyperpigmentation disorders, including melanocyte apoptosis, and modulation of aromatic hydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogeneration, melanosome transport, melanocyte activity and melanin concentration.

This application provides a skin color detection method and apparatus for use in a laser hair removal device. The laser hair removal device includes a control board and a treatment head. The treatment head contains a contact sensor and a skin color detection component. The light outlet of the treatment head has a skin color detection window and a contact detection part arranged circumferentially. The light outlet, skin color detection window, and contact detection part of the treatment head are arranged on a common end face. The method includes: the control board acquiring a contact signal collected by the contact sensor through the contact detection part, and determining whether the light outlet of the treatment head is in contact with the skin based on the contact signal; after determining that the light outlet of the treatment head is in contact with the skin, the control board controls the skin color detection component to collect the skin color signal through the skin color detection window, and determines the skin color type based on the skin color signal. The technical solution of this application provides high accuracy in determining the skin color type, and the control parameters determined according to the user's skin color also match the user's skin color, resulting in stable hair removal effect without skin damage.

The present application relates to the technical field of medicine, and particularly relates to a drug composition with a sequential synergistic repair effect and a preparation method and application thereof. The drug composition comprises liposome I encapsulating caffeic acid and liposome II encapsulating BH4; the liposome I is a ROS-responsive liposome, can specifically respond in a high ROS microenvironment, and then realize on-demand release of caffeic acid; meanwhile, the liposome II protects BH4 from entering cells to play a role, can effectively overcome the defects of difficult dissolution of caffeic acid and easy oxidation of caffeic acid and BH4, can improve the bioavailability of the two drugs, can realize sequential release of caffeic acid and BH4, and can play a synergistic treatment effect on different mechanisms of occurrence of radioactive skin damage, and provides a sequential synergistic repair strategy for clinic. The liposome I and the liposome II are both prepared by a thin film hydration method, and the operation is simple, the conditions are mild, the lipid film is uniformly formed, and the encapsulation rates of caffeic acid and BH4 are high.

This invention relates to the field of power grid operation safety technology, and discloses a method and system for intelligent identification of transmission line outer sheath damage based on deep learning. The method includes the following steps: acquiring original images and BeiDou coordinates, completing timestamp alignment and basic preprocessing to obtain an enhanced image as the inference input; using a unified model to perform multi-task inference on the enhanced image, outputting a multi-instance inference set, and performing temperature calibration on the classification confidence, calculating the centroid / box center, normalizing the severity, and measuring uncertainty; the multi-instance inference set includes bounding boxes, segmentation masks, severity scores, classification confidence, and uncertainty. This invention can suppress the impact of positioning errors on identification and early warning in scenarios with obstruction and multipath conditions such as valleys, urban canyons, and metal structure reflections, reducing the risks of missed detections, false detections, and delayed handling, improving stability and robustness in complex weather and long corridor scenarios, and achieving all-weather, low-latency, and traceable on-site management.

The application provides a kind of prevent drainage tube indentation protection bellyband, comprising: bellyband main body, the side of bellyband main body is provided with first magic tape, the other side of bellyband main body is provided with second magic tape;Second magic tape is connected with first magic tape by adhesion;Pressure relief cushion, pressure relief cushion is set between first magic tape and second magic tape;Pressure relief cushion is connected to bellyband main body on the side close to the outer edge of bellyband main body, gap is set between pressure relief cushion and bellyband main body, and gap is used to place drainage tube;Drainage tube channel, drainage tube channel is set between first magic tape and pressure relief cushion, and between second magic tape and pressure relief cushion;Drainage tube channel is used to pass through drainage tube, so that drainage tube is connected with drainage bag, to solve the problem that current protection bellyband is fixed drainage tube and is easy to form indentation on the skin of patient, even cause skin damage;When patient is active, drainage tube is prone to displacement or folding, leading to poor drainage and inconvenience to patients.

Provided is a combination of at least two of creatine, bifida ferment lysate and sechium edule fruit extract to repair DNA damage to the skin caused by light in the range 280-1400 nm. These agents are combined with UV filters and optionally one or more blue light and / or one or more IR reflector(s) in cosmetic compositions used to prevent sun-induced damage to the skin, in particular to prevent senolytic or senomorphic senescence and / or appearance of the visible signs of skin aging, in particular one or more of fine lines, wrinkles, age spots, skin dryness, thinning of the skin and loss of elasticity.

This invention relates to the fields of biomedicine and nanomaterials, specifically to a curcumin-containing metal-organic framework nanocomposite material, its preparation method, and its applications. The metal-organic framework nanocomposite material uses the metal-organic framework MIL-101(Cr) as a substrate and introduces Ag... + As a functional component and Cr 3+ A bimetallic node is formed, and curcumin, as an active functional ingredient, is encapsulated within the pores of MIL-101(Cr) and / or modified on its surface, forming a carrier-bimetallic-functional ingredient composite structure. This composite material exhibits excellent performance and good biocompatibility. The preparation method is simple and highly controllable, making it suitable for industrial production. Furthermore, it expands the application scenarios of this composite material, providing new solutions for the treatment of clinical bacterial infections and the repair of skin lesions.

The application belongs to the technical field of molecular biology, and relates to a polypeptide with a light protection function and application of the polypeptide. An amino acid sequence of the polypeptide comprises a sequence shown in SEQ ID No. 1 or SEQ ID No. 2. The polypeptide disclosed by the application is derived from heat-soluble protein, has a significant light protection effect, can effectively prevent and repair skin damage caused by light, has strong stability, has no sensitization, has no phototoxicity, and has a good application prospect.

The utility model discloses a kind of postoperative shaping auxiliary devices for neck and back, applied in rehabilitation engineering technical field, including support plate, the top of the support plate is bolted with fixed plate, the top of the front of fixed plate is bolted with adjusting box;The utility model can reduce blood stasis caused by long-term braking by moderate activity design, accelerate inflammation subsides and wound healing, reduce muscle spasm and nerve compression on the basis of maintaining neck physiological curvature, relieve postoperative pain, reduce postoperative muscle fatigue and joint stiffness by dispersing neck pressure, improve patient comfort degree;While maintaining the stability of spine, allow moderate activity, avoid muscle atrophy or joint stiffness caused by long-term complete braking, support device shares back muscle load, relieve postoperative muscle fatigue and spasm caused by compensatory effort, buffer layer reduces the friction of skin and hard brace, reduce the risk of skin damage caused by long-term wearing.

This invention discloses a compound ointment for protecting the nasal mucosa and repairing skin damage, and its preparation method, belonging to the field of pharmaceutical technology. The compound ointment is formulated with Sophora japonica fruit extract, erythromycin ointment, vitamin B6, levofloxacin hydrochloride tablets, loratadine tablets, fluticasone propionate nasal spray, sesame oil, and honey in specific weight proportions. The components work synergistically, providing protection for the nasal mucosa, treatment of rhinitis, reduction of cold air and external pollutant intrusion, and prevention of colds. It can also treat hemorrhoids, scars, eczema, and other skin damage, achieving "one medicine for multiple uses." This compound ointment has a stable dosage form, is convenient to use, has high utilization rate, high safety, and no obvious side effects, making it suitable for various populations and possessing good industrialization prospects.

The technical objective of this invention is to provide a protective pad against skin conditions. Destroyed by extreme cold for the cryolipolysis process, where the component... Waterproofing may be provided to prevent tearing or with waterproof components and base parts. It may be prevented from separating during the negative pressure process and Waterproof components can be easily attached to the base components without defects. In this case, a protective pad is used to prevent skin damage from extreme cold during the fat breakdown process. This invention's cooling agent is a protective pad against frostbite that is designed to prevent skin damage. The design is intended for use in cryolipolysis (fat freezing) procedures utilizing a fat-dissolving device. Cooling and protective padding against frostbite will include a base component made of... Made from fibrous materials, one or more waterproof components made from resin materials, and... It is placed by overlapping the base components and one or more stitched sections that are made by... Sew the base assembly and the waterproof assembly together to connect the base assembly and the waterproof assembly. Waterproof in a condition where the base component and the waterproof component are superimposed;

This application relates to the field of pharmaceutical technology, and in particular to a topical ointment formulation and its preparation method. The formulation uses Sonicate as the active ingredient, combined with petrolatum, liquid paraffin, a solubilizing and penetration-enhancing system, and emulsifiers as excipients, to form an O / W type cream, an oil-based or water-soluble ointment. The preparation process employs a low-temperature dosing method at 40°C to ensure drug activity and inhibit crystallization. This application achieves high-concentration retention in local skin tissue through topical administration, significantly reducing radiation damage scores and pathological damage, while resulting in extremely low systemic plasma exposure, avoiding the systemic toxicity of oral administration, and providing a safe and efficient means for the clinical prevention and treatment of radiation-induced skin damage.

This invention relates to polypeptides and their applications in repairing mucosal or skin damage. The polypeptides of this invention are not homologous to known polypeptides and can exist stably both in vivo and in vitro, and have the effect of regulating stem cell proliferation and differentiation to repair mucosal or skin damage; as well as the use of the novel polypeptides in repairing mucosal or skin damage by regulating stem cell proliferation and differentiation, and their use in preventing, alleviating or treating gastrointestinal diseases.

The utility model relates to the technical field of agriculture, forestry, concretely discloses a kind of sapling protection devices with windproof structure for agriculture and forestry tree-planting, including annular frame body, is circumferentially spliced into by four support frames;Each support frame includes multiple layers of arc-shaped plates arranged in parallel at intervals, and adjacent arc-shaped plates are fixedly connected by multiple support rods;Windproof mechanism, including the arc-shaped wind shield plate arranged outside support frame, the elastic buffer assembly is arranged between the wind shield plate and arc-shaped plate;The elastic buffer assembly includes tubular sleeve fixed to the outer wall of arc-shaped plate, guide rod fixed to the inner wall of wind shield plate, the other end of the guide rod is slidably sleeved in tubular sleeve, and buffer spring is sleeved on the sleeve and guide rod;The device realizes the multiple beneficial effects of windproof, impact resistance, self-adaptive sapling growth and skin damage prevention through the synergistic effect of annular frame body and elastic buffer mechanism, combined with adjustable sapling positioning system.

This utility model relates to the field of medical device technology, and in particular to an automatically lifting tourniquet soaking box. The technical solution includes an outer box and a movable top cover on the top of the outer box, and further includes: a soaking box movably placed inside the outer box to hold the tourniquet; and a lifting mechanism installed on the inner wall of the outer box to move the soaking box up and down. This utility model utilizes the cooperation of the soaking box, lifting mechanism, and timing mechanism to place the tourniquet in the soaking box. By synchronously activating a pair of multi-stage cylinders, the soaking box automatically lowers the tourniquet into the disinfectant solution, where the tourniquet disinfects the hemostasis. Simultaneously, when the hourglass timer ends, an ultrasonic sensor automatically raises the soaking box, causing the tourniquet to be removed from the disinfectant solution. This avoids damage to the tourniquet due to prolonged soaking in the disinfectant solution if not retrieved in time, and also reduces the risk of skin damage or corrosion to medical personnel when handling and using disinfectants.

This invention relates to the field of medical materials technology, providing a hydrogel containing antler mesenchymal stem cell exosomes, its preparation method, and applications. The method includes the following steps: preparation of antler mesenchymal stem cell exosomes; preparation of PVP-HA composite hydrogel; uniformly mixing AMSC-Exos with a hydrogel precursor solution, and forming a hydrogel containing antler mesenchymal stem cell exosomes through physical embedding and non-covalent interactions. This invention utilizes the three-dimensional porous network structure of the hydrogel to achieve long-term sustained release of exosomes, protecting them from rapid degradation; it leverages the unique regenerative advantages of antler-derived exosomes to synergistically promote angiogenesis, inhibit inflammatory responses, and regulate macrophage polarization; it promotes angiogenesis through the miR-486-5p / FGF9 axis, achieving efficient repair of chronic diabetic wounds; and it provides a novel, efficient, safe, and clinically translational strategy for the treatment of chronic diabetic skin lesions.

This application relates to a flexible flipping lifting device for skin panels, belonging to the field of aircraft manufacturing. The lifting device has attitude adjustment capabilities in the air, allowing it to be adjusted to the required assembly posture during lifting, thus improving assembly efficiency. One lifting device can lift multiple skin panel workpieces, effectively improving lifting efficiency and significantly reducing tooling costs and storage space requirements. The lifting device uses vacuum suction cups to adsorb the skin; the evenly distributed vacuum suction cups ensure uniform force distribution during lifting, effectively preventing skin damage caused by stress concentration.

This invention discloses a method for preparing and applying a dual-network sprayable hydrogel for the repair of radiation-induced skin damage. The hydrogel introduces aldehyde groups into Polygonatum odoratum polysaccharide via sodium periodate oxidation, causing it to chemically crosslink with the amino groups of quaternized chitosan to form a first-layer network. Simultaneously, sodium alginate is introduced into the system, and calcium ions are used to crosslink and construct a second-layer physical crosslinking network. This invention achieves instant gelation upon injection under physiological conditions, effectively avoiding the operational complexity caused by pre-mixed crosslinking agents and optimizing gel performance. The resulting hydrogel exhibits significantly improved mechanical and adhesive properties. In vitro cell experiments and in vivo animal experiments show that this sprayable hydrogel can effectively promote cell proliferation and migration, effectively maintain macrophage mitochondrial dysfunction caused by ionizing radiation, and possesses good antioxidant and anti-inflammatory activities, demonstrating broad application prospects in the repair and treatment of radiation dermatitis.

The present application relates to the technical field of medical preparations or cosmetics, in particular to the technical field of preparation of active ingredients of plant origin in medical preparations or cosmetics, and discloses a preparation process of centella asiatica extract, which comprises the following steps: adopting enzyme-assisted hot ethanol extraction method, combining with resin purification technology to extract and obtain a centella asiatica concentrated product from centella asiatica; preparing a centella asiatica extract molecular imprinting polymer resin and filling and loading the resin into a solid-phase extraction empty column to prepare a resin column, and purifying the centella asiatica concentrated product through the resin column to prepare the centella asiatica extract with a purity of up to 99%. The prepared centella asiatica extract has the effects of repair and soothing, can be used as an active ingredient in medical preparations or cosmetics, and is used for preparing a gel preparation for treating skin damage, or is added into a repair skin care product to promote skin barrier repair and soothe damaged parts, so that the medical-grade skin care effect and daily care are combined.

This application discloses a squalene / calcium phosphotungsten oleogel, its preparation method, and its applications, relating to the field of biomedical technology. The squalene / calcium phosphotungsten oleogel is composed of squalene and calcium phosphotungsten nanowires; by mass percentage, the calcium phosphotungsten nanowire content is 2-5%, and the squalene content is 95-98%. The squalene / calcium phosphotungsten oleogel exerts anti-inflammatory and antioxidant effects by scavenging excess ROS, and can restore cell membrane fluidity, weaken mechanosensitive YAP pathway activation, and synergistically promote photoaging repair and scarless healing through multiple pathways. This comprehensive regulatory strategy provides a new solution for skin damage repair.

The application discloses a sesquiterpene compound in llex spicata and an extraction and separation method and application thereof, relates to the technical field of plant chemical extraction and separation, and provides a sesquiterpene compound in llex spicata, which is characterized by comprising at least one of llex spicata lactone F, llex spicata lactone G and llex spicata lactone H. The application provides an extraction method of the sesquiterpene compound in llex spicata, and the three sesquiterpenes obtained by the extraction and separation method are all new compounds which have not been reported. The llex spicata sesquiterpene compound has antibacterial and anti-inflammatory activities, and has potential development value for diseases such as fungal infection, pharyngitis and pneumonia. The llex spicata sesquiterpene compound also has the effects of skin damage repair and anti-aging, and can be applied to the field of cosmetics.

The utility model discloses a foot protection device of preventing pressure sore, including protection pad, both sides of protection pad are fixedly connected with first buffer pad and second buffer pad respectively, protection pad is equipped with two ankle joint and heel placement opening, first buffer pad is equipped with the U -shaped groove of size adaptation with ankle joint placement opening, protection pad adopts the breathable sponge material, and the inside fills memory cotton, first buffer pad and second buffer pad are all silica gel material, and the surface is provided honeycomb breathable hole, the utility model discloses through the elastic buffer effect of first buffer pad and second buffer pad, the pressure of ankle and heel part is evenly dispersed, avoids the local sustained pressure to lead to ischemia and anoxia, and simultaneously, the breathable material of protection pad and buffer pad can keep the foot dry, reduces the growth of perspiration, reduces the risk of skin damage.

The application discloses a preparation method and application of microneedles for repairing radioactive skin damage, and adopts a physical crosslinking method to prepare the microneedles, thereby avoiding residues of organic solvents and small molecule crosslinking agents and having good biocompatibility and degradability. The microneedles can penetrate the cuticle of the skin to accurately deliver drugs to the epidermis, rapidly gel in the skin and realize programmed release of the drugs: firstly, mangiferin is released to remove active oxygen generated by radiation burst and prevent oxidative DNA damage; and then, keratin nanoparticles are continuously released to inhibit inflammatory reactions by regulating the NF-kappa B signal pathway, simultaneously play an anti-apoptosis role and up-regulate the expression of cell keratin, thereby promoting barrier reconstruction and hair follicle regeneration. The microneedle system realizes early-stage antioxidant prevention, late-stage anti-inflammatory and anti-apoptosis and regeneration-promoting phased synergistic treatment, has the effects of removing active oxygen, inhibiting inflammation, resisting cell apoptosis and promoting epidermal regeneration, and can significantly improve the repair efficiency of radioactive skin damage.

A waist belt for preventing and treating menstrual cramps. This invention discloses a waist belt for preventing and treating menstrual cramps, including a waist belt body, a Velcro fastening device, a device body, a pressing block, a pressing head, a storage box, a liquid outlet, a stop block, and a control device. The pressing block is driven by an electric telescopic rod to perform massage. When the pressing head deviates due to friction with the skin, it triggers an active mechanism to open the liquid outlet, achieving precise release of lubricant and medication. The stop block ensures even application of the medication, preventing accumulation. The waist belt body is equipped with a heating element and a temperature sensor to achieve constant-temperature heat therapy. This waist belt integrates heat therapy, micro-massage, drug penetration, and adaptive lubrication, effectively relieving menstrual cramps, avoiding skin damage, and is safe and convenient to use.

967.526NL1 Provided is a combination of at least two of creatine, bifida ferment lysate and sechium edule fruit extract to repair DNA damage to the skin caused by light in the range 280-1400 nm. These agents are combined with UV filters and optionally one or more blue light and / or one or more IR reflector(s) in cosmetic compositions used to prevent sun-induced damage to the skin, in particular to prevent senolytic or senomorphic senescence and / or appearance of the visible signs of skin aging, in particular one or more of fine lines, wrinkles, age spots, skin dryness, thinning of the skin and loss of elasticity.

The application relates to application of cedrene diol in preparation of medicines for preventing and treating rosacea, and belongs to the technical field of biological medicines. The application provides application of cedrene diol in preparation of medicines for preventing and / or treating rosacea. The cedrene diol can significantly improve redness and inflammation of an injection area of a rosacea mouse model in long and short terms, can significantly relieve skin histopathological inflammation of the rosacea mouse model (including improving thickening of skin epidermis of the rosacea mouse model, reducing inflammatory cell infiltration of skin tissue of the rosacea mouse model, and reducing capillary proliferation of skin tissue of the rosacea mouse model), can significantly reduce skin inflammation of a rosacea patient (including reducing pain of the skin of the rosacea patient and relieving redness of the skin of the rosacea patient), and can significantly improve skin damage of the rosacea patient (including improving papules and pustules of the skin of the rosacea patient).