743 results about "Skin damage" patented technology

The invention relates to an aircraft surface damage area segmentation method based on adaptive multi-modal fusion, belongs to the technical field of nondestructive testing, and solves the technical problem of low segmentation precision of an aircraft skin curved surface falling damage area. Obtaining a grey-scale map, a depth map and a point cloud map of the aircraft surface damage skin; synthesizing the grey-scale map, the depth map and the point cloud map, and performing preprocessing, feature extraction, feature conversion, image display and projection and weighted fusion on the synthesized grey-scale map, the synthesized depth map and the synthesized point cloud map to obtain a total edge probability map of skin damage; and performing targeted screening, continuity detection, connectivity detection, convex hull construction, marking and skin falling damage area division on the total edge probability graph. The method is used for aircraft skin health monitoring, maintenance guarantee and operation and maintenance.

The invention provides a radiotherapy patient skin injury real-time detection record management system based on image processing, and belongs to the technical field of radiotherapy patient skin injury real-time detection. Comprising a multispectral image acquisition module for imaging the skin of a patient at the same visual angle by adopting different spectrums to obtain three spectral images including near-infrared imaging, infrared imaging and ultraviolet imaging; a first identification module is used for fusing three spectral images to obtain an image data set, and a second identification module is used for constructing an epidermis injury coefficient # imgabs0 #, a dermis injury coefficient # imgabs1 # and a subcutaneous injury coefficient # imgabs2 # of the ith patient and evaluating the epidermis injury coefficient # imgabs0 #, the dermis injury coefficient # imgabs1 # and the subcutaneous injury coefficient # imgabs2 # respectively. A skin injury evaluation model is constructed, the comprehensive injury area ratio is calculated, the classification of injury levels is realized, data support is provided for a personalized treatment scheme, and a powerful auxiliary diagnosis tool is provided for a medical institution.

The invention provides a micromolecular multifunctional information peptide and application thereof, and belongs to the technical field of active peptide raw material development. The sequence of the small-molecule multifunctional information peptide is VHPYVPR, the small-molecule multifunctional information peptide can be effectively combined with a downstream receptor of EGF, the EGF function is simulated, and meanwhile the situation that use of existing cell growth factor raw materials in the field of cosmetics is limited due to the molecular weight problem is avoided. Experiments prove that the micromolecular multifunctional information peptide provided by the invention can promote the repair of skin damage phenomena such as scratches, inhibit the release of inflammatory factors, inhibit the activity of beta-galactosidase and promote the generation of I-type, III-type and XVII-type collagen, shows excellent repair, soothing and anti-aging functions, is high in permeability and has a wide application prospect.

The embodiment of the invention provides an aircraft skin damage identification method and device, equipment, a storage medium and a product. The method comprises the following steps: acquiring an initial point cloud of an aircraft skin surface through structured light equipment, and performing data preprocessing on the initial point cloud to obtain a preliminary correction point cloud; calculating reflection intensity distribution of each area on the surface of the aircraft skin based on the preliminary correction point cloud, and determining a compensated point cloud; extracting geometric features from the compensated point cloud, and performing denoising processing on the compensated point cloud to obtain a denoised point cloud; constructing a three-dimensional grid model representing a three-dimensional structure of the aircraft skin surface based on the de-noised point cloud, and determining a damage candidate area of the aircraft skin surface; obtaining a point cloud subset associated with the damage candidate area and carrying out damage type classification on the point cloud subset to obtain a classification result of damage types; according to a classification result, generating a damage labeling graph; and based on the damage marking graph, calibrating the damage size parameter to generate a final damage report.

The invention relates to the technical field of material nondestructive testing, in particular to a CFRP wing skin damage positioning system and method based on multi-modal signal processing and Bayesian optimization DSCN, and the method comprises the steps: carrying out permutation entropy analysis and Higuchi fractal dimension analysis on a signal data set received by a sensor; performing time-frequency feature extraction on the sensor receiving signal data set deviating from the reference; performing damage feature screening on the signal data in the effective time period; training the DSCN structure to obtain an initial CFRP wing skin damage positioning prediction model; performing hyper-parameter optimization on the initial CFRP wing skin damage positioning prediction model according to a Bayesian algorithm; and performing damage positioning prediction on a to-be-detected sample according to the final CFRP wing skin damage positioning prediction model to obtain a corresponding CFRP wing skin damage positioning result. According to the method, effective damage features can be accurately and efficiently extracted from complex signals, and the accuracy and efficiency of CFRP wing skin damage positioning are remarkably improved.

Disclosed are methods of treating radiation-induced skin damage comprising administering extracellular vesicle and protein compositions.

The present invention provides a phycocyanin-collagen composite hydrogel and its preparation method and application. The present invention utilizes transglutaminase to catalyze the combination of phycocyanin and collagen to form a new, more stable collagen; transglutaminase acts between protein molecules, utilizes lysine and glutamic acid in phycocyanin and collagen to transfer acyl groups, and cross-links to form new chemical bonds, thereby enhancing the binding strength of phycocyanin and collagen; the hydrogel prepared by the present invention can be used to prepare medical materials and combined with skin injury sites to solve the problem that traditional dressings are easy to adhere to wounds and easily penetrated by tissue fluid and become infected. In addition to ensuring basic air permeability, it reduces the adhesion of the dressing, increases moisture retention and antioxidant properties, and avoids secondary damage when replacing a new dressing. The hydrogel prepared by the present invention has a certain antioxidant capacity and can be used to prepare products with antioxidant effects.

The invention discloses a therapeutic nano-vesicle preparation rich in mitochondrial functional protein, a preparation method of the therapeutic nano-vesicle preparation and application of the therapeutic nano-vesicle preparation in treatment of radioactive skin injury. The preparation method comprises the following steps: culturing, amplifying and cleaning umbilical cord mesenchymal stem cells, dispersing the umbilical cord mesenchymal stem cells in a suspension, mechanically extruding the umbilical cord mesenchymal stem cells into a crude solution through a multistage aperture polycarbonate membrane, and centrifuging, concentrating and purifying the crude solution to obtain the preparation. The preparation has the remarkable advantages that local administration can be realized, inflammation can be quickly inhibited, oxidative stress is reduced, and a repair pathway is activated, so that the preparation is suitable for treating acute radioactive skin injury; the preparation method is easy to standardize and scale, high in stability and convenient for emergency storage and delivery, and avoids the defects of cell therapy; a plurality of targets such as immune inflammation, oxidative stress and the like can be synergistically regulated, the biological effect of hUMSCs is simulated and partially replaced, and the limitation caused by the cell survival rate and the microenvironment dependency is avoided; the key function of hUMSCs is covered in function, and the clinical feasibility, safety and emergency suitability of the application level are higher.

An embodiment relates to a light emitting diode (LED) mask for personal combination stimulation, which is to be worn on a face, and more specifically to an LED mask for personal combination stimulation, which can prevent skin damage due to heat generation caused by light emission in an LED, reduce manufacturing and maintenance costs, and effectively make improvement such as whitening facial skin, reducing wrinkles, in particular, wrinkles around eyes. The LED mask for personal combination stimulation includes a mask unit to be put on the face of a user; and a light irradiation unit installed in the mask unit and including a plurality of LEDs arranged on a substrate, wherein the LEDs comprise multiple types of LED chips to emit light of different wavelengths, and the multiple types of LED chips are configured as a combination LED module in a single support structure and arrange on the substrate.

The invention belongs to the field of cell biology, particularly relates to stem cell exosome repair gel and a preparation method thereof, and more particularly relates to stem cell exosome repair gel containing active biological peptide and a preparation method thereof. The invention provides a repairing composition which comprises an active peptide as shown in SEQ ID NO.1 and a stem cell exosome. The repair gel provided by the invention contains the active peptide and the stem cell exosome loaded with the bioactive substances, and the components have a synergistic effect, so that the expression level of related cell factors can be improved, the repair after skin injury is promoted, and the physiological state of the skin is improved.

The invention belongs to the technical field of microorganisms, and particularly relates to an extracellular vesicle of phytobacterium plantarum and application of the extracellular vesicle. Specifically, the plant lactobacillus extracellular vesicles can promote HaCaT cells to generate ceramide, up-regulate expression of key genes in a skin ceramide synthesis route and recover a skin barrier; the expression of proinflammatory factors in a cell inflammation model can be reduced, and a relatively good anti-inflammatory effect is achieved. A mouse skin injury model verifies that the EVs has good skin infiltration capacity and can remarkably reduce the skin injury score, relieve skin itch, improve the skin water content and reduce expression of proinflammatory factors in skin tissue and expression of pruritus-related cell factors.

The invention discloses a transcranial electrical stimulation control method and system for regulating mental fatigue, and belongs to the technical field of mental state regulation. The system comprises an EEG collecting and processing module and an electrical stimulation module which are in wireless communication to form a closed loop. The EEG collecting and processing module collects a forehead lobe three-lead EEG signal, after preprocessing (baseline drift and high-frequency interference are removed through FIR filtering, and eye movement artifacts are removed through combination of wavelet transform and Kalman filtering), the mental fatigue state is classified through an onboard lightweight convolutional neural network (CNN) algorithm, and a control command is generated; the electrical stimulation module receives the command, generates bipolar pulse width modulation transcranial direct current stimulation (tPWMDCs) current, and stimulates the prefrontal lobe. Local low-power-consumption reasoning of EEG signals is achieved, tPWMDCs avoid skin injury, a closed-loop system dynamically adapts to individual differences, portability, safety and accuracy are achieved, and the system is suitable for driving, office and other scenes.

The invention discloses a deep learning aircraft skin damage detection method suitable for a dark light condition, and the method comprises the following steps: enabling an unmanned plane to fly around an aircraft to obtain the original image data of the aircraft skin damage, carrying out the preprocessing of the collected image data, completing the screening and label marking, and carrying out the detection of the aircraft skin damage. The invention relates to the technical field of aircraft skin detection, in particular to an aircraft skin damage detection method based on a PENet network, an aircraft skin damage data set needed by a training network is made, image data of the training data set is input into the PENet network, the dark light information capture rate is increased, and the training data set processed by the PENet is input into an improved yolov8 network and a CSPDarknet backbone network for feature extraction. The SCConv module is used for carrying out CNN compression by using space and channel redundancy between features, redundancy calculation is reduced, learning of representative features is promoted, the training calculation amount is reduced, the model is lightened, the model training time is shortened, an algorithm is deployed on the unmanned aerial vehicle, consumption of manpower and material resources can be greatly reduced, and the detection cost is reduced.

The invention provides cytokine hydrogel as well as a preparation method and application thereof in skin injury repair, and belongs to the technical field of biological medicines. Comprising the following steps: (1) adding beta-GP into a chitosan solution to obtain a CS-beta-GP pregel solution; (2) dissolving Pluronic F127 and hyaluronic acid in a PBS (Phosphate Buffer Solution) until the Pluronic F127 and the hyaluronic acid are completely transparent to obtain an F127-HA solution; and (3) sequentially dissolving trehalose, cordycepin, a cell factor composition and collagen peptide in a PBS solution, incubating to obtain a cell factor mixed solution, and mixing the cell factor mixed solution with the CS-beta-GP pregel solution and the F127-HA solution. According to the invention, a dual temperature-sensitive system is established, the gel can be quickly formed under the conditions of injection at low temperature and body temperature, the effective period of active ingredients is prolonged by utilizing a trehalose stabilization technology, and meanwhile, the anti-inflammatory effect of cordycepin and the cell repair effect of collagen peptide are combined, so that the efficient repair of skin injury can be realized.

The present specification relates to a composition for skin protection, which comprises, as an active ingredient, thymol 3, 4, 5-trimethoxycinnamate (3, 4, 5-Trimethoxycinnate Thymol Ester), a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof. The composition according to the present disclosure improves the expression of a DNA repair-related gene in skin cells that are photo-aged by ultraviolet light, thereby being capable of inhibiting or preventing skin damage caused by ultraviolet light or external environment or oxidative stress.

The invention relates to the technical field of automobile electrical detection, provides an automobile wire harness wire insulation skin damage detection method and system, and aims to solve the technical problem that a certain loop insulation skin damage position point is difficult to find in the prior art. Comprising a plane capacitance sensor used for measuring capacitance change between the plane capacitance sensor and a to-be-measured wire harness to obtain a charge signal used for representing the damage state of an insulating material of the to-be-measured wire harness; the charge amplifier is used for performing voltage conversion and amplification processing on the charge signal to obtain a voltage signal; the impedance analyzer is used for calculating impedance through the voltage signal and the current signal, drawing a Bode diagram based on the obtained impedance, and performing index parameter extraction on the Bode diagram to obtain various index parameters; and the upper computer is used for carrying out feature extraction on the multiple index parameters to obtain feature data, and analyzing the damage state of the insulating material of the wire harness to be detected according to the feature data to obtain a detection result.

The invention relates to application of a vitamin E compound in preparation of a MACIR protein targeting agent. The vitamin E compound comprises any one or a combination of at least two of tocopherol, tocopherol derivatives, tocotrienol or tocotrienol derivatives. The invention creatively discovers the interaction between tocopherol, tocopherol derivatives, tocotrienol or tocotrienol derivatives and MACIR protein, and proves the strong binding capacity of tocopherol or derivatives thereof and MACIR protein through experiments. The tocopherol, the tocopherol derivative, the tocotrienol or the tocotrienol derivative can be used for regulating the function of MACIR protein associated immune cells so as to influence the expression of inflammatory factors, play an important role in inflammation and anaphylaxis, and also can be used for improving skin injury repair.

The invention discloses an emotional beautifying composition applicable to sensitive skin and a preparation method and application thereof, and relates to the technical field of cosmetics. The composition disclosed by the invention is prepared from the following components in parts by weight: 0.08 to 6 parts of coba resin, 0.005 to 2 parts of acetyl tetrapeptide-15, 0.06 to 6 parts of tephrosia rubescens seed extract, 0.008 to 3 parts of citrus fruit extract and 0.008 to 4 parts of herba schizonepetae extract. According to the composition disclosed by the invention, combination of the coxia resin, the acetyl tetrapeptide-15, the tephrosia glauca seed extract, the citrus fruit extract and the herba schizonepetae extract shows that the composition has a synergistic interaction effect, and the composition formed by specific compatibility of the components can relieve skin injury caused by emotion fluctuation, relieve pressure, bring pleasure to the skin and prevent the skin from being damaged by emotional fluctuation. The oil outlet and sensitive conditions of the skin are improved from inside to outside, the effects of pleasure, oil control and soothing are achieved, and the oil-sensitive skin care product is particularly suitable for oil-sensitive skin crowds to use.

The invention relates to the field of medical instruments, and discloses a low-temperature scald early warning system for preventing percutaneous acupoint electrical stimulation assisted anesthesia. Comprises: a data acquisition module configured to acquire baseline information of a patient, electric energy output cumulant data of an electrical stimulation device and real-time temperature data of an electrode slice application area; the control module is configured to determine a skin injury risk coefficient based on the patient baseline information, calculate an energy accumulation value of a current application area in combination with the electric energy output accumulation amount data, and calculate an energy accumulation value of the current application area according to a preset low-temperature scald risk model; inputting the skin injury risk coefficient, the energy accumulation value and the real-time temperature data into the low-temperature scald risk model, and calculating to obtain a dynamically adjusted low-temperature scald early-warning threshold value; and when the real-time temperature data reaches the low-temperature scald early-warning threshold value, early-warning information is pushed to a medical care terminal according to a preset time period, and the early-warning information at least comprises an application area position, a current temperature value and suggested examination time.

The invention relates to a fused exosome-like vesicle based on stem cell exosomes and application thereof, and the fused exosome-like vesicle is prepared by a method comprising the following steps: mixing stem cell exosomes and aloe exosome-like vesicles under an ultrasonic condition, and incubating to obtain the fused exosome-like vesicle. The fused exosome-like vesicle can effectively promote percutaneous penetration of stem cell exosome, and can effectively improve cell damage caused by ultraviolet rays, regenerate and repair skin damage barriers such as basilar membranes and the like, resist inflammation and oxidation, effectively remove melanin, and improve the skin quality. The composition has good repair potentials for chloasma and skin damage, aging and melanin deposition related to chloasma. Sufficient data support and technical support are provided for research and development of stem cell exosome innovative drugs, and clinical application of the stem cell exosome innovative drugs is accelerated.

The utility model discloses a front traction bracket for orthodontics, which comprises a plurality of vertical rods, one end of each vertical rod is provided with a placing component, one end of each vertical rod is provided with an adjusting component I and an adjusting component II, and the adjusting component I is provided with an auxiliary component. The front support can be provided for counter-acting force generated by traction, so that the acting point is more reliable, the stress area is wider, the pressure of the contact surface is greatly reduced, medical breathable sponge pads are attached to the inner side of the lower jaw surrounding baffle and the inner side of the lower jaw supporting plate, lower jaw skin injury caused by stress is relieved to the maximum extent, and the safety of the lower jaw is improved. By additionally arranging the enclosure pressing plate and the jaw support pressing plate on the outer sides of the lower jaw enclosure plate and the lower jaw support plate, the medical gauze can be conveniently and quickly fixed by medical staff or patients subsequently, the medical staff or the patients can conveniently replace the medical gauze, and the problem that the skin is in contact with the front traction bracket for orthodontics for a long time, bacteria are bred, and then rash is caused can be effectively solved.

The invention discloses a saccharomycetes lysate, a preparation method and application, and the main components of the saccharomycetes lysate comprise the following components accounting for the relative content of the saccharomycetes lysate: 93-98% of nucleoside, nucleotide and derivatives thereof; and 0.2 to 6% of amino acid; wherein the nucleoside, the nucleotide and the derivatives of the nucleoside and the nucleotide comprise one or more of adenosine, succinyladenosine, adenosine-3 '-phosphoric acid, inosine and S-adenosine homocysteine. Effect evaluation is carried out on the saccharomycetes lysate, and verification shows that the saccharomycetes lysate has the effects of whitening, repairing skin injury, preventing light and aging, resisting pollution and oxidation, resisting inflammation and relieving, protecting hair and preventing hair loss, replenishing water and preserving moisture, and enhancing skin vitality or removing dark circles.

The invention discloses an application of Chinese yam derived exosome-like nanoparticles in preparation of skin injury repairing products, the exosome-like nanoparticles are derived from natural medicinal and edible plants, and have no cytotoxicity to skin keratinocytes HaCaT; scratch cell migration experiments are carried out, and it is found that healing can be rapidly promoted, and the anti-inflammatory effect is achieved. The invention further provides a preparation method of the Chinese yam-derived exosome-like nano-particles, Chinese yam tissue raw stock is separated through centrifugal treatment and sucrose gradient centrifugation, the high-purity exosome-like nano-particles are prepared, and the method is simple in technological process and easy to implement.

The invention, which belongs to the technical field of medical image processing and computer vision, discloses a multispectral imaging-assisted post-radiotherapy skin injury early detection system comprising a multispectral data acquisition module, a deep tissue feature extraction module, a three-dimensional lesion segmentation module and a space-time tracking evaluation module. The subcutaneous 2.5 cm depth tissue information is obtained through multispectral imaging at the wave band of 400-1350nm, blood perfusion, melanin concentration, collagen structure and other physiological parameters are inversed based on the radiation transfer theory, a three-dimensional medical image segmentation algorithm is adopted to achieve three-dimensional accurate segmentation of an injury area, a spatio-temporal evolution model is established to predict the injury development trend, and the damage development trend is predicted. The radioactive skin injury can be detected in the subclinical period, the detection time window is advanced by 5.2 days on average, the occurrence rate of severe dermatitis is reduced by 65%, and a basis is provided for clinical timely intervention.

The instant invention relates to a semi-solid topical composition containing Pirfenidone and an antimicrobial / antiseptic agent such as Modified Diallyl Disulfide Oxide (M-DDO) and its preparation process, offering advantages compared to other pharmaceutical forms of topical administration known in the state of the art, useful as antifibrotic, anti-inflammatory and antiseptic agent in the prevention, treatment and reversion of acne and post acne lesions. Said compositions is also useful for reducing skin redness, detaining the formation of new acne outbreaks, reversing already existing outbreaks and regenerating skin damage caused by acne.

The invention discloses a deep learning aircraft skin damage detection method suitable for rain and fog conditions. The deep learning aircraft skin damage detection method comprises the following steps that an unmanned aerial vehicle obtains original image data; preprocessing the image data, and making a data set; inputting the image data of the training data set into the AOD-Net integrated defogging network; inputting the training data set into a CSPDarknet backbone network for feature extraction, and introducing an ECA channel attention mechanism; the method relates to the technical field of aircraft skin damage detection, the damage detection effect of the aircraft skin under the foggy condition can be effectively enhanced, meanwhile, local cross-channel interaction is captured in combination with an ECA attention mechanism, and the detection accuracy is improved. According to the method, the feature response of each channel can be adaptively adjusted, the channels related to the rain stripe features are enhanced, accurate damage detection under most rain and fog conditions can be ensured, and resources can be saved to the maximum extent and the detection cost can be reduced by relying on the lightweight features of AOD-Net and ECA.

The present invention belongs to the field of traditional Chinese medicines, and particularly relates to Leixihaokang, a preparation method therefor, and use thereof. The Leixihaokang of the present invention is prepared from the following active pharmaceutical ingredients in parts by weight: 10 parts of Tripterygium glycosides and 0.1-1.3 parts of Artemisia annua extract. According to the present invention, animal experiments prove that the Leixihaokang can ameliorate renal damage in nephrotic syndrome caused by adriamycin, reduce the occurrence of proteinuria, and reduce the apoptosis of renal tissue cells. Meanwhile, the Leixihaokang of the present invention has a good inhibitory effect on renal, hepatic, splenic, and cardiac toxicity in the treatment process of nephrotic syndrome. According to the present invention, animal experiments also prove that the Leixihaokang can ameliorate skin injury in imiquimod-induced psoriasis, reduce inflammatory infiltration and alleviate skin damage. Meanwhile, the Leixihaokang has a certain degree of inhibitory effect on the hepatic and reproductive system toxicity in the treatment process of psoriasis.

The invention provides a composition and cream with anti-inflammatory and skin barrier injury repairing effects as well as a preparation method and application of the composition and cream, and belongs to the technical field of skin injury repairing. The invention provides a composition with anti-inflammatory and skin barrier injury repairing effects. The composition is prepared from matrine, dipotassium glycyrrhizinate, bisabolol and asiaticoside according to the weight ratio of 1: 1: 1: 1. The composition provided by the invention can play a role through a multi-target mechanism, such as up-regulation of Invoucrin, and provides a more effective prevention and treatment scheme for skin barrier dysfunction related diseases and sensitive skin.

The present invention is relates to a compound of formula (I), wherein X1, X2 and X3 are, independently of each other, N or CH; with the proviso that at least two of X1 X2 and X3 are N; Y is N or CH; W is H or F; with the proviso that when W is F, then X1, X2 and X3 are N; R1 and R2 are independently of each other (i) a morpholinyl of formula (II) wherein the arrow denotes the bond in formula (I); and wherein R3 and R4 are independently of each other H, C1-C3alkyl optionally substituted with one or two OH, C1-C2fluoroalkyl, C1-C2alkoxy, C1alkoxyC1-C3alkyl, CN, or C(O)O-C1-C2alkyl; or R3 and R4 form together a bivalent residue -R5R6- selected from C1-C3alkylene optionally substituted with 1 to 4 F, -CH2-O-CH2-, -CH2-NH-CH2-, or any of the structures wherein the arrows denote the bonds in formula (II); or (ii) a saturated 6-membered heterocyclic ring Z selected from thiomorpholinyl and piperazinyl, optionally substituted by 1 to 3 R7; wherein R7 is independently at each occurrence C1-C3alkyl optionally substituted with one or two OH, C1-C2fluoroalkyl, C1-C2alkoxyC1-C3alkyl, C3-C6cycloalkyl; or two R7 substituents form together a bivalent residue-R8R9- selected from Ci-C3alkylene optionally substituted with 1 to 4 F, -CH2-O-CH2- or -O-CH2CH2-O-; with the proviso that at least one of R1 and R2 is a morpholinyl of formula II; and prodrugs, metabolites, tautomers, solvates and pharmaceutically acceptable salts thereof, for use in the prevention or treatment of a skin lesion in a subject.

The invention relates to the technical field of biological active peptides, in particular to a method for rapidly and effectively screening light protection active peptides from collagen hydrolysate. The invention relates to an application of a photoprotective polypeptide in preparation of a product. The product has at least one of the following purposes: (1) maintaining or increasing the water content of skin; (2) preventing and / or slowing down skin aging; (3) prevention and / or alleviation of skin UVB injury; and (4) promoting healing of skin wounds or wound surfaces. Two key signal factors (NF-kB, AP-1) and a key matrix metalloproteinase (MMP-9) are screened from a mitogen-activated protein kinase (MAPK) and nuclear factor-kB (NF-kB) pathway to be used as docking targets, and a mimic peptide and the three targets act synergistically to make up for the defect that a single target screening peptide is difficult to comprehensively cope with a light damage multivariate pathway, so that the application of the mimic peptide to the light damage multivariate pathway is realized, and the application of the mimic peptide to the light damage multivariate pathway is realized. And the collagen peptide with excellent light protection activity is obtained through screening.