951 results about "Skin damage" patented technology

The invention relates to an aircraft surface damage area segmentation method based on adaptive multi-modal fusion, belongs to the technical field of nondestructive testing, and solves the technical problem of low segmentation precision of an aircraft skin curved surface falling damage area. Obtaining a grey-scale map, a depth map and a point cloud map of the aircraft surface damage skin; synthesizing the grey-scale map, the depth map and the point cloud map, and performing preprocessing, feature extraction, feature conversion, image display and projection and weighted fusion on the synthesized grey-scale map, the synthesized depth map and the synthesized point cloud map to obtain a total edge probability map of skin damage; and performing targeted screening, continuity detection, connectivity detection, convex hull construction, marking and skin falling damage area division on the total edge probability graph. The method is used for aircraft skin health monitoring, maintenance guarantee and operation and maintenance.

The invention relates to the field of biological medicines, in particular to a facial anti-aging collagen peptide, a composition and an application of the facial anti-aging collagen peptide, and particularly relates to a 21-type recombinant humanized collagen peptide (ColpepA1 21) and an application of a composition of the 21-type recombinant humanized collagen peptide in anti-aging treatment and skin care. The recombinant collagen provided by the invention can effectively promote the repair process after skin injury, enhance the hydration state and barrier function of the skin, reduce fine lines and wrinkles, and improve the compactness and elasticity of the skin.

The invention belongs to the technical field of preparation of microorganisms and cosmetics, and particularly relates to a strain composition, radix paeoniae rubra fermentation liquor prepared from the strain composition and application of the strain composition in cosmetics. Specifically, Pseudoalteromonas sp. SE9 and Schizoscharomyces pombe JM2-16 are utilized to perform fermentation treatment on radix paeoniae rubra root powder, and the finally obtained radix paeoniae rubra fermentation liquor has multiple effects of resisting oxidation, promoting proliferation and migration of keratinocytes, promoting skin injury repair, resisting allergy, resisting inflammation, relieving and the like, is high in safety, can be used as a cosmetic component, and can be used as a cosmetic preparation. Therefore, the method has good practical application value.

The invention provides a radiotherapy patient skin injury real-time detection record management system based on image processing, and belongs to the technical field of radiotherapy patient skin injury real-time detection. Comprising a multispectral image acquisition module for imaging the skin of a patient at the same visual angle by adopting different spectrums to obtain three spectral images including near-infrared imaging, infrared imaging and ultraviolet imaging; a first identification module is used for fusing three spectral images to obtain an image data set, and a second identification module is used for constructing an epidermis injury coefficient # imgabs0 #, a dermis injury coefficient # imgabs1 # and a subcutaneous injury coefficient # imgabs2 # of the ith patient and evaluating the epidermis injury coefficient # imgabs0 #, the dermis injury coefficient # imgabs1 # and the subcutaneous injury coefficient # imgabs2 # respectively. A skin injury evaluation model is constructed, the comprehensive injury area ratio is calculated, the classification of injury levels is realized, data support is provided for a personalized treatment scheme, and a powerful auxiliary diagnosis tool is provided for a medical institution.

The invention belongs to the technical field of medical dressings for repairing skin injury wounds, and provides a nanofiber wound dressing with a photo-thermal chemical synergistic antibacterial effect and a preparation method. A PVA / CS solution composed of polyvinyl alcohol PVA and chitosan CS is used as an electrospinning matrix, branched polyethyleneimine BPEI modified graphene oxide GO nanoparticles GO-BPEI are added to serve as a photo-thermal antibacterial component, lanthanum chloride is added to serve as a chemical antibacterial component, an electrostatic spinning solution is prepared, the electrostatic spinning solution is subjected to electrostatic spinning, and the PVA / CS / GO-BPEI / La nanofiber wound dressing is obtained. The obtained fiber surface has a good three-dimensional structure, shows obvious chemical antibacterial ability, can be subjected to photothermal conversion under near-infrared light illumination, can achieve the purpose of photothermal bacteriostasis, further improves the antibacterial property, and has good mechanical property, air permeability, water absorption and biocompatibility at the same time.

The invention discloses aloe exosome-like nano-vesicles capable of delaying skin photoaging and an extraction method and application thereof, and belongs to the technical field of exosome-like nano-vesicle extraction. The extraction method of the aloe exosome-like nano-vesicles is designed and optimized, the yield of the aloe exosome-like nano-vesicles is obviously improved, and the extracted aloe exosome-like nano-vesicles can obviously delay skin photoaging and have an obvious improvement effect on skin fibroblast aging damage caused by ultraviolet radiation; a potential treatment means is provided for preventing or treating actinic keratosis caused by ultraviolet radiation and further possible squamous cell carcinoma.

The invention provides a micromolecular multifunctional information peptide and application thereof, and belongs to the technical field of active peptide raw material development. The sequence of the small-molecule multifunctional information peptide is VHPYVPR, the small-molecule multifunctional information peptide can be effectively combined with a downstream receptor of EGF, the EGF function is simulated, and meanwhile the situation that use of existing cell growth factor raw materials in the field of cosmetics is limited due to the molecular weight problem is avoided. Experiments prove that the micromolecular multifunctional information peptide provided by the invention can promote the repair of skin damage phenomena such as scratches, inhibit the release of inflammatory factors, inhibit the activity of beta-galactosidase and promote the generation of I-type, III-type and XVII-type collagen, shows excellent repair, soothing and anti-aging functions, is high in permeability and has a wide application prospect.

The invention provides a soothing and repairing composition for oil-sensitive skin and application of the soothing and repairing composition, and belongs to the technical field of cosmetics. According to the soothing and repairing composition, the hydrolyzed yeast protein, the aesculus chinensis extract, the marine oligosaccharide, the Australian tealeaf extract and the phellinus igniarius extract are compounded to form the soothing and repairing composition, and the soothing and repairing composition reduces skin discomfort by maintaining the steady state of an enzyme network of epidermis, reducing oxidase and increasing enzymes and defensive enzymes for promoting Newcastle metabolism; the effects of repairing, moisturizing, controlling oil and relieving are achieved, the skin injury of oily sensitive skin is gently repaired, and the health state of the skin is recovered.

The embodiment of the invention provides an aircraft skin damage identification method and device, equipment, a storage medium and a product. The method comprises the following steps: acquiring an initial point cloud of an aircraft skin surface through structured light equipment, and performing data preprocessing on the initial point cloud to obtain a preliminary correction point cloud; calculating reflection intensity distribution of each area on the surface of the aircraft skin based on the preliminary correction point cloud, and determining a compensated point cloud; extracting geometric features from the compensated point cloud, and performing denoising processing on the compensated point cloud to obtain a denoised point cloud; constructing a three-dimensional grid model representing a three-dimensional structure of the aircraft skin surface based on the de-noised point cloud, and determining a damage candidate area of the aircraft skin surface; obtaining a point cloud subset associated with the damage candidate area and carrying out damage type classification on the point cloud subset to obtain a classification result of damage types; according to a classification result, generating a damage labeling graph; and based on the damage marking graph, calibrating the damage size parameter to generate a final damage report.

The invention relates to the technical field of material nondestructive testing, in particular to a CFRP wing skin damage positioning system and method based on multi-modal signal processing and Bayesian optimization DSCN, and the method comprises the steps: carrying out permutation entropy analysis and Higuchi fractal dimension analysis on a signal data set received by a sensor; performing time-frequency feature extraction on the sensor receiving signal data set deviating from the reference; performing damage feature screening on the signal data in the effective time period; training the DSCN structure to obtain an initial CFRP wing skin damage positioning prediction model; performing hyper-parameter optimization on the initial CFRP wing skin damage positioning prediction model according to a Bayesian algorithm; and performing damage positioning prediction on a to-be-detected sample according to the final CFRP wing skin damage positioning prediction model to obtain a corresponding CFRP wing skin damage positioning result. According to the method, effective damage features can be accurately and efficiently extracted from complex signals, and the accuracy and efficiency of CFRP wing skin damage positioning are remarkably improved.

Disclosed are methods of treating radiation-induced skin damage comprising administering extracellular vesicle and protein compositions.

The invention discloses a steroid compound as well as a preparation method and application thereof. The invention specifically discloses a steroid compound with a structure as shown in a formula I and the like or a pharmaceutically acceptable salt of the steroid compound. The compound provided by the invention has SREBP pathway inhibitory activity, and can be used for preventing and / or treating obesity, hyperlipidemia, fatty liver, diabetes, atherosclerosis, cardiovascular and cerebrovascular diseases, liver cancer, skin injury and other diseases. # imgabs0 #

The present invention provides a phycocyanin-collagen composite hydrogel and its preparation method and application. The present invention utilizes transglutaminase to catalyze the combination of phycocyanin and collagen to form a new, more stable collagen; transglutaminase acts between protein molecules, utilizes lysine and glutamic acid in phycocyanin and collagen to transfer acyl groups, and cross-links to form new chemical bonds, thereby enhancing the binding strength of phycocyanin and collagen; the hydrogel prepared by the present invention can be used to prepare medical materials and combined with skin injury sites to solve the problem that traditional dressings are easy to adhere to wounds and easily penetrated by tissue fluid and become infected. In addition to ensuring basic air permeability, it reduces the adhesion of the dressing, increases moisture retention and antioxidant properties, and avoids secondary damage when replacing a new dressing. The hydrogel prepared by the present invention has a certain antioxidant capacity and can be used to prepare products with antioxidant effects.

The invention discloses a therapeutic nano-vesicle preparation rich in mitochondrial functional protein, a preparation method of the therapeutic nano-vesicle preparation and application of the therapeutic nano-vesicle preparation in treatment of radioactive skin injury. The preparation method comprises the following steps: culturing, amplifying and cleaning umbilical cord mesenchymal stem cells, dispersing the umbilical cord mesenchymal stem cells in a suspension, mechanically extruding the umbilical cord mesenchymal stem cells into a crude solution through a multistage aperture polycarbonate membrane, and centrifuging, concentrating and purifying the crude solution to obtain the preparation. The preparation has the remarkable advantages that local administration can be realized, inflammation can be quickly inhibited, oxidative stress is reduced, and a repair pathway is activated, so that the preparation is suitable for treating acute radioactive skin injury; the preparation method is easy to standardize and scale, high in stability and convenient for emergency storage and delivery, and avoids the defects of cell therapy; a plurality of targets such as immune inflammation, oxidative stress and the like can be synergistically regulated, the biological effect of hUMSCs is simulated and partially replaced, and the limitation caused by the cell survival rate and the microenvironment dependency is avoided; the key function of hUMSCs is covered in function, and the clinical feasibility, safety and emergency suitability of the application level are higher.

An embodiment relates to a light emitting diode (LED) mask for personal combination stimulation, which is to be worn on a face, and more specifically to an LED mask for personal combination stimulation, which can prevent skin damage due to heat generation caused by light emission in an LED, reduce manufacturing and maintenance costs, and effectively make improvement such as whitening facial skin, reducing wrinkles, in particular, wrinkles around eyes. The LED mask for personal combination stimulation includes a mask unit to be put on the face of a user; and a light irradiation unit installed in the mask unit and including a plurality of LEDs arranged on a substrate, wherein the LEDs comprise multiple types of LED chips to emit light of different wavelengths, and the multiple types of LED chips are configured as a combination LED module in a single support structure and arrange on the substrate.

The invention belongs to the field of cell biology, particularly relates to stem cell exosome repair gel and a preparation method thereof, and more particularly relates to stem cell exosome repair gel containing active biological peptide and a preparation method thereof. The invention provides a repairing composition which comprises an active peptide as shown in SEQ ID NO.1 and a stem cell exosome. The repair gel provided by the invention contains the active peptide and the stem cell exosome loaded with the bioactive substances, and the components have a synergistic effect, so that the expression level of related cell factors can be improved, the repair after skin injury is promoted, and the physiological state of the skin is improved.

The present invention provides a soothing, moisturizing and repairing composition and its application, which relates to the technical field of daily chemicals. The present invention has a soothing, moisturizing and repairing composition with Artemisia annua extract, Centella asiatica extract and Gentiana yunnanensis extract as main components, and the raw materials are selected from natural ingredients such as Artemisia annua, Centella asiatica, Gentiana yunnanensis, etc., which is non-toxic and non-irritating to human skin and has high safety; further, the product of the present invention can be used to repair skin damage caused by various reasons, and has anti-inflammatory and moisturizing effects. It is applied to cosmetics and skin care products, such as gel, emulsion, cream, essence, etc., which is gentler to the human body, safe and non-irritating.

The invention belongs to the technical field of microorganisms, and particularly relates to an extracellular vesicle of phytobacterium plantarum and application of the extracellular vesicle. Specifically, the plant lactobacillus extracellular vesicles can promote HaCaT cells to generate ceramide, up-regulate expression of key genes in a skin ceramide synthesis route and recover a skin barrier; the expression of proinflammatory factors in a cell inflammation model can be reduced, and a relatively good anti-inflammatory effect is achieved. A mouse skin injury model verifies that the EVs has good skin infiltration capacity and can remarkably reduce the skin injury score, relieve skin itch, improve the skin water content and reduce expression of proinflammatory factors in skin tissue and expression of pruritus-related cell factors.

The invention discloses a transcranial electrical stimulation control method and system for regulating mental fatigue, and belongs to the technical field of mental state regulation. The system comprises an EEG collecting and processing module and an electrical stimulation module which are in wireless communication to form a closed loop. The EEG collecting and processing module collects a forehead lobe three-lead EEG signal, after preprocessing (baseline drift and high-frequency interference are removed through FIR filtering, and eye movement artifacts are removed through combination of wavelet transform and Kalman filtering), the mental fatigue state is classified through an onboard lightweight convolutional neural network (CNN) algorithm, and a control command is generated; the electrical stimulation module receives the command, generates bipolar pulse width modulation transcranial direct current stimulation (tPWMDCs) current, and stimulates the prefrontal lobe. Local low-power-consumption reasoning of EEG signals is achieved, tPWMDCs avoid skin injury, a closed-loop system dynamically adapts to individual differences, portability, safety and accuracy are achieved, and the system is suitable for driving, office and other scenes.

Disclosed are a steroid compound having a structure represented by formula (I) or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a use thereof. The compound has SREBP pathway inhibitory activity, and can be used for preventing and / or treating diseases such as obesity, hyperlipidemia, fatty liver, diabetes, atherosclerosis, cardiovascular and cerebrovascular diseases, liver cancer, and skin injury.

The invention discloses a deep learning aircraft skin damage detection method suitable for a dark light condition, and the method comprises the following steps: enabling an unmanned plane to fly around an aircraft to obtain the original image data of the aircraft skin damage, carrying out the preprocessing of the collected image data, completing the screening and label marking, and carrying out the detection of the aircraft skin damage. The invention relates to the technical field of aircraft skin detection, in particular to an aircraft skin damage detection method based on a PENet network, an aircraft skin damage data set needed by a training network is made, image data of the training data set is input into the PENet network, the dark light information capture rate is increased, and the training data set processed by the PENet is input into an improved yolov8 network and a CSPDarknet backbone network for feature extraction. The SCConv module is used for carrying out CNN compression by using space and channel redundancy between features, redundancy calculation is reduced, learning of representative features is promoted, the training calculation amount is reduced, the model is lightened, the model training time is shortened, an algorithm is deployed on the unmanned aerial vehicle, consumption of manpower and material resources can be greatly reduced, and the detection cost is reduced.

The invention provides cytokine hydrogel as well as a preparation method and application thereof in skin injury repair, and belongs to the technical field of biological medicines. Comprising the following steps: (1) adding beta-GP into a chitosan solution to obtain a CS-beta-GP pregel solution; (2) dissolving Pluronic F127 and hyaluronic acid in a PBS (Phosphate Buffer Solution) until the Pluronic F127 and the hyaluronic acid are completely transparent to obtain an F127-HA solution; and (3) sequentially dissolving trehalose, cordycepin, a cell factor composition and collagen peptide in a PBS solution, incubating to obtain a cell factor mixed solution, and mixing the cell factor mixed solution with the CS-beta-GP pregel solution and the F127-HA solution. According to the invention, a dual temperature-sensitive system is established, the gel can be quickly formed under the conditions of injection at low temperature and body temperature, the effective period of active ingredients is prolonged by utilizing a trehalose stabilization technology, and meanwhile, the anti-inflammatory effect of cordycepin and the cell repair effect of collagen peptide are combined, so that the efficient repair of skin injury can be realized.

The present specification relates to a composition for skin protection, which comprises, as an active ingredient, thymol 3, 4, 5-trimethoxycinnamate (3, 4, 5-Trimethoxycinnate Thymol Ester), a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof. The composition according to the present disclosure improves the expression of a DNA repair-related gene in skin cells that are photo-aged by ultraviolet light, thereby being capable of inhibiting or preventing skin damage caused by ultraviolet light or external environment or oxidative stress.

The invention provides a stem cell exosome repairing agent and a preparation method thereof, and the repairing agent comprises stem cell exosome, hyaluronic acid, collagen, vitamin E, glutathione, an anti-inflammatory agent, liposome nanoparticles and sterile water according to specific parts by weight. Wherein the anti-inflammatory agent is prepared from a selfheal extract, an aloe extract and a liquorice extract in a specific proportion. The preparation method comprises the following steps: separation and purification of stem cell exosomes, preparation of liposome nanoparticles, formation of a compound, preparation of a mixed solution and preparation of a final repairing agent. High-purity stem cell exosomes are obtained through specific centrifugation, incubation, separation, elution and purification steps and fused with liposome nano-particles, then the fused product is mixed with an anti-inflammatory agent and other components, and the repairing agent is obtained through ultrasonic treatment. The repairing agent disclosed by the invention has a good clinical application prospect and provides a new choice for skin injury treatment.

The invention relates to the technical field of automobile electrical detection, provides an automobile wire harness wire insulation skin damage detection method and system, and aims to solve the technical problem that a certain loop insulation skin damage position point is difficult to find in the prior art. Comprising a plane capacitance sensor used for measuring capacitance change between the plane capacitance sensor and a to-be-measured wire harness to obtain a charge signal used for representing the damage state of an insulating material of the to-be-measured wire harness; the charge amplifier is used for performing voltage conversion and amplification processing on the charge signal to obtain a voltage signal; the impedance analyzer is used for calculating impedance through the voltage signal and the current signal, drawing a Bode diagram based on the obtained impedance, and performing index parameter extraction on the Bode diagram to obtain various index parameters; and the upper computer is used for carrying out feature extraction on the multiple index parameters to obtain feature data, and analyzing the damage state of the insulating material of the wire harness to be detected according to the feature data to obtain a detection result.

The present invention relates to the field of biomedical materials, and specifically to a three-layer composite structure collagen-based artificial skin and a preparation method thereof. The artificial skin comprises a three-layer structure, which is respectively a silicone membrane layer-collagen membrane layer-collagen sponge layer from top to bottom, wherein the thickness of the silicone membrane layer is 0.3-1 mm, the thickness of the collagen membrane layer is 0.4-10 μm, the thickness of the collagen sponge layer is 1.5-5 mm, and the total thickness is 1.8-7 mm. The main components of the porous scaffold layer of the artificial skin material are yak collagen and chondroitin sulfate, which are obtained by gradient temperature rise freeze-drying and double cross-linking treatment. The artificial skin not only has good mechanical strength, swelling performance and anti-enzymatic performance, but also has good biological activity and full-thickness skin injury wound repair effect, and has broad application prospects in the medical field.

The invention relates to application of a vitamin E compound in preparation of a MACIR protein targeting agent. The vitamin E compound comprises any one or a combination of at least two of tocopherol, tocopherol derivatives, tocotrienol or tocotrienol derivatives. The invention creatively discovers the interaction between tocopherol, tocopherol derivatives, tocotrienol or tocotrienol derivatives and MACIR protein, and proves the strong binding capacity of tocopherol or derivatives thereof and MACIR protein through experiments. The tocopherol, the tocopherol derivative, the tocotrienol or the tocotrienol derivative can be used for regulating the function of MACIR protein associated immune cells so as to influence the expression of inflammatory factors, play an important role in inflammation and anaphylaxis, and also can be used for improving skin injury repair.

The invention discloses an emotional beautifying composition applicable to sensitive skin and a preparation method and application thereof, and relates to the technical field of cosmetics. The composition disclosed by the invention is prepared from the following components in parts by weight: 0.08 to 6 parts of coba resin, 0.005 to 2 parts of acetyl tetrapeptide-15, 0.06 to 6 parts of tephrosia rubescens seed extract, 0.008 to 3 parts of citrus fruit extract and 0.008 to 4 parts of herba schizonepetae extract. According to the composition disclosed by the invention, combination of the coxia resin, the acetyl tetrapeptide-15, the tephrosia glauca seed extract, the citrus fruit extract and the herba schizonepetae extract shows that the composition has a synergistic interaction effect, and the composition formed by specific compatibility of the components can relieve skin injury caused by emotion fluctuation, relieve pressure, bring pleasure to the skin and prevent the skin from being damaged by emotional fluctuation. The oil outlet and sensitive conditions of the skin are improved from inside to outside, the effects of pleasure, oil control and soothing are achieved, and the oil-sensitive skin care product is particularly suitable for oil-sensitive skin crowds to use.

The invention aims to provide a cold compress device for repairing skin injury and caring skin, and relates to the technical field of medical instruments, two side plates are symmetrically arranged on a base in a sliding mode, a soaking assembly is arranged on the base and located between the side plates, and a rotating plate of the soaking assembly is rotated to drive two soaking plates to clamp gauze to soak the gauze; the gauze can be quickly soaked; a rotating head is rotatably mounted on a side plate, gauze on a soaking plate is clamped through a clamping assembly, a width adjusting motor in a rotating seat drives a bidirectional lead screw to rotate, clamping plates are driven to slide in opposite directions, the width of the clamped gauze is reduced, and a torsion motor on the side plate drives the rotating seat to rotate, so that the gauze is tightened. The tightened gauze is loosened by reversing the twisting motor, then the clamping plates are driven by the reversing width adjusting motor to slide back to back, the clamped gauze is unfolded, the gauze can be more conveniently wet-applied to the skin, the gauze can be more rapidly twisted to be free of water dripping through the twisting motor, and the wet-applying efficiency is improved.

The invention relates to the field of medical instruments, and discloses a low-temperature scald early warning system for preventing percutaneous acupoint electrical stimulation assisted anesthesia. Comprises: a data acquisition module configured to acquire baseline information of a patient, electric energy output cumulant data of an electrical stimulation device and real-time temperature data of an electrode slice application area; the control module is configured to determine a skin injury risk coefficient based on the patient baseline information, calculate an energy accumulation value of a current application area in combination with the electric energy output accumulation amount data, and calculate an energy accumulation value of the current application area according to a preset low-temperature scald risk model; inputting the skin injury risk coefficient, the energy accumulation value and the real-time temperature data into the low-temperature scald risk model, and calculating to obtain a dynamically adjusted low-temperature scald early-warning threshold value; and when the real-time temperature data reaches the low-temperature scald early-warning threshold value, early-warning information is pushed to a medical care terminal according to a preset time period, and the early-warning information at least comprises an application area position, a current temperature value and suggested examination time.