The invention discloses a low-loss large-effective area single mode fiber and a manufacturing method of the low-loss large-effective area single mode fiber, and relates to the field of optical fibers. The low-loss large-effective area single mode fiber comprises a quartz glass cladding, an internal coating and an external coating, wherein the quartz glass cladding, the internal coating and the external coating are arranged in sequence from inside to outside; the inside of the quartz glass cladding comprises a first fiber core area, a second fiber core area, a third fiber core area, a fourth fiber core area and a refractive index concave cladding, wherein the first fiber core area, the second fiber core area, the third fiber core area, the fourth fiber core area and the refractive index concave cladding are arranged in sequence from inside to outside; the refractive index concave cladding is subjected to deposition through a PCVD process; the quartz glass cladding is manufactured through an OVD process or a sleeving process. According to the low-loss large-effective area single mode fiber and the manufacturing method of the low-loss large-effective area single mode fiber, the scattering loss of the low-loss large-effective area single mode fiber and the additional loss of the low-loss large-effective area single mode fiber in a bent state can be reduced; due to the fact that the spire distribution of fiber core basic mode electromagnetic field power is adjusted into flattop distribution, optical power density is reduced, the effective area of the low-loss large-effective area single mode fiber is enlarged, the nonlinearity of the low-loss large-effective area single mode fiber is reduced, the incident power of an optical fiber communication system is increased by 0.4-2.6 dB, and the low-loss large-effective area single mode fiber is suitable for mass production.