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18750results about "Optical light guides" patented technology

Integrated active flux microfluidic devices and methods

InactiveUS6767706B2Rapid and complete exposureQuick and accurate and inexpensive analysisBioreactor/fermenter combinationsFlow mixersAntigenHybridization probe
The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen/antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e., polynucleotides, proteins, or antigen/antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene. Hybridization probes can be immobilized on a substrate that forms part of or is exposed to a channel or channels of the device that form a closed loop, for circulation of sample to actively contact complementary probes. Universal chips according to the invention can be fabricated not only with DNA but also with other molecules such as RNA, proteins, peptide nucleic acid (PNA) and polyamide molecules.
Owner:CALIFORNIA INST OF TECH

Beam expanding optical element, beam expansion method, image display apparatus, and head-mounted display

A first HOE and a second HOE are respectively arranged on two opposite faces of an optical waveguide member. The first HOE diffracts light incident from the outside on the optical waveguide member such that the light is then totally reflected inside the optical waveguide member and is thereby directed to the second HOE. The second HOE diffracts, according to the diffraction efficiency thereof, part of the light incident thereon after being guided inside the optical waveguide member such that this part of the light is then emitted to the outside substantially parallel to the light incident on the optical waveguide member, and the second HOE simultaneously totally reflects the rest of the light incident thereon. The second HOE repeats such emission and total reflection. The first and second HOEs each have interference fringes with n different pitches (where n is a natural number equal to or greater than two) to diffract light of n different wavelengths at substantially equal angles. Thus, even when light of n different wavelengths is incident on the optical waveguide member, the second holographic diffractive optical element emits it to the outside with substantially equal pitches for the light of the n different wavelengths.
Owner:KONICA MINOLTA INC
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