34 results about "Mammalian tissue" patented technology

Microneedle patches that include a backing layer, and an array of microneedles extending from the backing layer. wherein the microneedles each include a core portion which includes a drug, and a shell portion and a cap portion, wherein the core portion is encapsulated within the shell portion and cap portion. The microneedles are configured to be inserted into mammalian tissue and then separate from the backing layer. The shell portion and / or the cap portion is biodegradable and delays release of the drug for an extended period.

The present technology provides compounds as well as compositions including such compounds useful in targeted radiotherapy of cancer and / or mammalian tissue overexpressing prostate specific membrane antigen (“PSMA”) where the compounds are represented by the following:or a pharmaceutically acceptable salt thereof,or a pharmaceutically acceptable salt thereof,or a pharmaceutically acceptable salt thereof,wherein M1 is independently at each occurrence an alpha-emitting radionuclide. Equivalents of such compounds are also disclosed.

The invention provides novel methods for analyzing (e.g., imaging) drugs in mammalian tissues, and methods for identifying drug targets and analyzing drug-target interactions.

The present technology is directed to compounds, intermediates thereof, compositions thereof, medicaments thereof, and methods related to the imaging of mammalian tissue via 18F-labeled peptide ligands disclosed herein.

Microneedles for drug delivery that include a wax or other meltable material and methods of making and using such microneedles are disclosed. A microneedle patch includes a backing layer; and an array of microneedles extending from the backing layer, wherein the microneedles each include a distal tip portion that includes a drug, and the microneedles are configured to be inserted into mammalian tissue and, at least a portion of each of the microneedles is configured to melt in the mammalian tissue. In some other cases, melt materials are used during manufacturing of the microneedles but do not melt in the skin.

Described herein are systems, methods, and interconnecting porous hydrogel blocks for generating mammalian tissue. A block may comprise a three-dimensional continuous polymeric matrix with a network of microporous cavities, and may be configured to interconnect with at least one other block. A system may comprise a plurality of blocks configured to interconnect to form a scaffold configured to cultivate one or more cell types organized into stratified layers. A method may comprise acquiring a plurality of blocks, interconnecting the blocks to form a scaffold configured to cultivate one or more cell types organized into stratified layers, and seeding at least one block with at least one cell type adherent to the block. Embodiments may comprise perfusing at least one block with culture media and / or harvesting mammalian tissue generated.

Aspects and embodiments relate to a tissue mimicking material, a clinical phantom including a tissue mimicking material and a method of manufacture of a tissue mimicking material. According to one aspect there is provided: a tissue mimicking material comprising: an alginate matrix; and an ablation-sensitive agent distributed through the alginate matrix. Aspects and embodiments recognise that use of an alginate matrix as a base for a tissue mimicking material provides relatively low cost material having various physical properties and characteristics which can be tuned or refined to simulate the characteristics of a mammalian tissue which the alginate matrix is intended to mimic. In relation to use of an alginate material in the context of thermal and / or pulsed electric field ablation simulation, it has been recognised that an alginate material may be appropriately temperature stable and not degrade upon exposure to high, or low, ablation temperatures, or upon exposure to ablation levels of pulsed electric field. Distribution of an appropriately selected ablation-sensitive agent through the alginate material may allow a change caused by application of an ablation technique to the tissue mimicking material to be observed.

A method of sterilizing biological tissue such as soft mammalian tissue that can be used to make bioprosthetic devices is disclosed. The method comprises contacting biological tissue with a bioburden reduction mixture, contacting biological tissue with a tissue drying mixture, and thereafter sterilizing the dry tissue with supercritical carbon dioxide. Prior to sterilizing the biological tissue with supercritical carbon dioxide, the biological tissue is placed under vacuum and, in some embodiments, is treated with a vaporized microbicide. Bioprosthetic devices made using the methods disclosed herein include bioprosthetic heart valves, biological tissue derived vascular grafts or vessels, and surgical tissue patches.

The present technology provides compounds as well as compositions including such compounds useful in targeted radiotherapy of cancer and / or mammalian tissue overexpressing prostate specific membrane antigen (“PSMA”) where the compounds are represented by the following:or a pharmaceutically acceptable salt thereof,or a pharmaceutically acceptable salt thereof,or a pharmaceutically acceptable salt thereof,wherein M1 is independently at each occurrence an alpha-emitting radionuclide. Equivalents of such compounds are also disclosed.

Provided is use of a protein synthesis inhibitor in promoting regeneration and repair capacity of mammal tissues or complex structures or organs. The protein synthesis inhibitor is a small molecule compound, from any of cycloheximide or an Amaryllidaceae extract, capable of promoting regeneration of mammal tissues and organs.

Disclosed herein are devices, systems, and methods for applying and / or delivering topical compounds (e.g., topical medications) to the surface of mammalian tissue (e.g., skin, mucous membranes, and / or other tissue surfaces). Specifically, disclosed embodiments include a device that is configured to connect to one or more types of known syringes, and, in particular, to one or more types of known syringe tips. At least one embodiment of the device comprises a cap and a membrane, where the cap includes an open connector end for engaging and / or attaching to a syringe via a syringe tip, a delivery end opposite to the connector end, and a cap body disposed between, and connecting, the connector end and the delivery end. The delivery end can further be connected to the membrane by, for instance, inserting one end of the membrane into the delivery end.

The invention relates to the field of dressings, in particular to a preparation method and application of an acellular biological matrix dressing. The decellularized biological matrix dressing is prepared by the following steps: decellularizing mammalian tissues, sequentially carrying out ion induction and crushing to obtain a crushed product, carrying out surface finishing and vacuum drying on the crushed product, and mixing to obtain the decellularized biological matrix dressing. The obtained acellular biological matrix dressing has a rougher surface and a more uniform roughness degree, so that the stability of the final product acellular biological matrix dressing and the capability of promoting cell adhesion are improved. When in use, the particle can be directly applied to various wounds, the complexity of using the particle in the prior art is reduced, and the particle can be directly covered on full-thickness skin defect wounds (such as deep wet wounds) and superficial wounds (such as dry epidermis injury).

Devices for carrying out subperiosteal minimally invasive jaw bone augmentation and reconstruction procedures, to develop a passageway and surgical site in a concealed area of patient tissue, where the surgical site is not exposed. The devices have shanks with specially configured tips to facilitate maneuvering the device through mammalian tissue to develop a tunnel in the tissue and a remote surgical site within the tissue. The device tips have one or more peripheral cutting surfaces that direct the positioning of the tunnel formation when the instrument handle is manipulated, e.g., by rotation, angular, forward or rearward motion. Embodiments of the devices are configured with tips that have a wide spread for cutting and elevating tissue, and with tips that may be maneuvered to condense bone graft material being implanted at a surgical site concealed within the tissue.

There is provided a liquid injection device (10) comprising an injection tube (12), wherein the injection tube (12) extends in a hollow tip (14) with a plurality of openings (16). At least three circumferentially displaced openings (16) are provided around the hollow tip (14) below an edge (15) of the hollow tip (14) and the hollow tip (14) is provided with a non-cutting edge. There is also provided a method for performing heat therapy of mammalian tissue, comprising the steps: inserting an injection tube (12) extending in a hollow tip (14) in a selected position in the tissue, injecting a liquid including at least one anesthetic and adrenaline heated to a temperature of at least 37° C through the injection tube and through a plurality of openings (16) 0 below an edge (15) of the hollow tip (14) into the mammalian tissue.

The invention provides novel methods for analyzing (e.g., imaging) drugs in mammalian tissues, and methods for identifying drug targets and analyzing drug-target interactions.

The present invention relates to methods for large tissue labeling, transparentizing and / or imaging using labeling agents (e.g., antibodies), as well as uses and products related thereto. The invention includes, inter alia, methods of preparing animal tissue for fluorescence microscopy, animal tissue obtainable by said methods, methods of analyzing said animal tissue, and methods for detecting transfers, analyzing the biological distribution of biopharmaceutical drugs, and analyzing the biological distribution of nanoparticles. The methods of making animal tissue according to the present invention encompass whole body marking, transparentizing and imaging methods. The method of the invention is advantageous in that: They allow for visualization of individual cells within mammalian tissue, including the entire mouse body or other large tissue, tumor metastasis at the single cell level, and visualization of the distribution of biopharmaceutical drugs (e.g., tumor metastasis, tumor metastasis, tumor metastasis, tumor metastasis, tumor metastasis, tumor metastasis, tumor metastasis, tumor metastasis, tumor metastasis, tumor metastasis, tumor metastasis, tumor metastasis, tumor metastasis, tumor metastasis, tumor metastasis, tumor metastasis, the distribution of cancer targeted therapy antibodies in a whole animal (e.g., a complete mouse).

The present application relates to, in certain aspects, methods and compositions for imaging mammalian brain tissue via detection of multiple different epitope tags delivered via a plurality of vectors. Certain aspects provided herein relate to binder sets for the multiple different epitope tags, and resulting compositions.

Compositions and methods for providing the hybrid benefit of treating biofilms on the surface of mammalian tissue, especially biofilms that occur in association with chronic wounds and burns, and simultaneously providing an antiseptic cleansing and maintenance of the stratum corneum of the tissue and other tissue surfaces, and an opportunity for the tissue to improve by engaging its own natural barrier and immunological defense properties. The compositions and methods prevent the re-establishment of biofilms by facilitating the reduction or eradication of the pathogen producing the biofilm before the biofilm can be established.

The present invention provides novel methods for analyzing (eg, imaging) drugs in mammalian tissues, as well as methods for identifying drug targets and analyzing drug-target interactions.

A thermally representative phantom mammalian manikin assembly is provided. The assembly can include a cover portion representative of mammalian tissue partially enclosing a thermal cavity having a thermally representative material therein. The cover portion can have an opening with a cap extending across the opening and configured to further enclose the thermal cavity. The cap can have an aperture extending therethrough to receive a device extending through the aperture and into the thermally representative material within the thermal cavity. The device can be a thermocouple configured to measure a temperature of the thermally representative material. In assemblies representing mammalian limbs, the assembly can further include a second thermal cavity representing an additional portion of the limb, e.g., thermally representative upper and lower leg cavities.

Provided herein are compounds useful for inducing biostasis. Also provided are pharmaceutical compositions comprising the compounds, kits comprising the compounds, methods of inducing biostasis in subjects, biological samples and cells, and methods of preserving biological samples (e.g., mammalian tissue) by a compound or composition described herein.

1. The name of the product under this design: stapler. 2. Application of the product with this design: It is used for internal suturing of mammalian tissues, and is particularly suitable for internal suturing of human tissues during minimally invasive or non-invasive surgery. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: a three-dimensional diagram of the combined state. 5. Other situations that require explanation: Component description: Component 1 is a suture needle, and component 2 is a suture device without a suture needle.

A liquid injection device may include an injection tube. The injection tube may extend to a hollow tip with a plurality of openings. At least three circumferentially displaced openings may be provided around the hollow tip below an edge of the hollow tip, and the hollow tip may be provided with a non-cutting edge. A method for performing heat therapy of mammalian tissue may involve inserting an injection tube extending to a hollow tip in a selected position in the tissue. A liquid including at least one anesthetic and adrenaline heated to a temperature of at least 37° C. may be injected through the injection tube and through a plurality of openings below an edge of the hollow tip into the mammalian tissue.

A brachytherapy composition fabricated from mammalian tissue is provided. Methods of processing a mammal's mammalian tissue to form a brachytherapy composition are provided. Regenerative methods are also provided.

Embodiments disclosed include systems, methods, and apparatuses, directed to administering thermal neural modulation to mammalian tissue to control nerve conduction. Embodiments disclosed include an apparatus comprising a thermal energy source, a first heat exchanger coupled to the thermal energy source and configured to receive thermal energy therefrom, a thermal applicator configured to be disposed and secured to the anatomy of a subject having a nerve therein, in contact with the skin on the anatomy and overlying a treatment portion of the nerve, the thermal applicator configured to transfer thermal energy to the skin to raise the temperature of the treatment portion of the nerve above a physiologic temperature, a second heat exchanger is coupled to the thermal applicator and configured to transfer thermal energy thereto, and a fluid conduit having a first portion coupled to the first heat exchanger and a second portion coupled to the second heat exchanger. The fluid conduit is configured to have fluid circulated therethrough to convey thermal energy from the thermal energy source via the first heat exchanger and to the thermal applicator via the second energy at a temperature.

The disclosure provides an antimicrobial composition comprising hypohalous acid and a salt of an organic acid, as well as methods of use for disinfecting mammalian tissue, including wounds and burns, and other uses.

The present technology is directed to compounds, intermediates thereof, compositions thereof, medicaments thereof, and methods related to the imaging of mammalian tissue via 18F-labeled peptide ligands disclosed herein.

Prosthetic heart valves having a conical shaped base valve structure formed from collagenous mammalian tissue and an expandable stent structure. The base valve structure includes a plurality of elongated ribbon members that are positioned proximate each other in a joined relationship, wherein the elongated ribbon members are positioned adjacent each other and form a plurality of fluid flow modulating regions that open when fluid into and through the base valve structure exhibits a positive pressure relative to the exterior pressure, i.e., a positive pressure differential, wherein the fluid is allowed to be transmitted out of the base valve structure, and transition to a closed configuration when the pressure differential between the interior valve pressure and exterior pressure reduces, wherein the fluid is restricted from flowing out of the base valve structure. The expandable stent structure includes a plurality of tethers adapted to pierce cardiovascular tissue and, thereby, position the base valve structure and, thereby, prosthetic valves formed therewith on said heart valve annulus.

Disclosed herein is an improved examination method for examining a fluorescence image taken of mammalian tissue treated with a fluorescent agent to be photosensitive and irradiated with excitation light, the fluorescence image (FI) comprising an array of pixels having respective fluorescence signal values, the fluorescence signal values include fluorescence signal values representing a first quantity (N1) of mammalian tissue in the fluorescence image. The improved inspection method comprises: determining (S6) a reference value (IR) such that a second number (N2) of fluorescence signal values contained in a first number of fluorescence signal values is less than or equal to said reference value and the remainder of the first number of fluorescence signal values exceeds said reference value, said second number being a predetermined fraction of said first number; determining (S7) an average fluorescence signal value ([mu] R) and a standard deviation ([sigma] R) of fluorescence signal values contained in the second number of fluorescence signal values; performing (S8) image segmentation in the fluorescence image (FI) to distinguish between a target region (TR) representing a portion identified as tumor tissue in the mammalian tissue (MT) and a reference region (RR) representing a remaining portion in the mammalian tissue (MT), including a determination for each pixel (p) and a determination for each pixel (p); determining that the pixel belongs to the target region (TR) if the signal-to-noise ratio CNR (p) of the pixel exceeds a predetermined threshold value (TCNR), otherwise determining that the pixel belongs to the reference region (RR), where the signal-to-noise ratio CNR (p) of the pixel is as defined in (I): (I) # imgabs0 # where FI (p) is the fluorescence signal value of the pixel (p), c is a predetermined constant; at least one contour (B) of the target area (TR) is identified (S9).

Aspect and embodiments relate to a tissue mimicking material, a clinical phantom including a tissue mimicking material and a method of manufacture of a tissue mimicking material. One aspect provides a tissue mimicking material comprising: an elastomeric solid foam. The foam comprises gas pockets dispersed in an elastomeric material matrix and a liquid lubricant arranged within the gas pockets of the elastomeric solid foam. Aspects and embodiments recognise that a self lubricating tissue mimicking material provides a mechanism to emulate particular in vivo mammalian tissues. The modified foam material in accordance with aspects has various physical properties and characteristics which can be tuned or refined to simulate the characteristics of a mammalian tissue which the foam is intended to mimic.