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37 results about "Bovine pericardium" patented technology
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Pericardium is a tough, double-layered membrane which covers the heart. Both bovine & porcine pericardium is harvested, cleaned, and processed as a biomaterial for use in several clinical applications. Principally composed of collagen, pericardium provides strength and elasticity.
Compressed tissue for heart valve leaflets
InactiveUS7141064B2Minimally-invasiveSame strengthStentsTubular organ implantsProsthesisBiomedical engineering
A process and system for compressing bioprosthetic tissue for use in medical implants. The process involves placing the tissue between two compressive surfaces and applying a force to reduce any nonuniformity of thickness in the tissue, while at the same time reduce the overall thickness. One particularly useful application is the compression of bioprosthetic sheet during the preparation of heart valve leaflets. Bovine pericardium may be compressed to reduce its thickness by about 50%, and then formed into heart valve leaflets. The thinned leaflets have substantially the same absolute strength as those made from uncompressed tissue, and are particular desirable for use in minimally invasive valves which must be compressed into a small profile. The thin tissue enables a reduction in the overall size of the minimally invasive heart valve for delivery. For instance, rolled MIS valves may be reduced in size to as small as 20 mm in diameter. Desirably, a cross-linking step is combined with the compression step to fix the reduced thickness of the tissue. One apparatus may include porous compression substrates through which a cross-linking solution may diffuse so as to perform the fixation and compression simultaneously.
Owner:EDWARDS LIFESCIENCES CORP
Method of preventing surgical adhesions
The present invention relates to a method and composition for preventing surgical adhesions during surgery. Tissue surfaces and / or surgical articles involved in the surgery are separated by a biomaterial provided in the form of a non-crosslinked, decellularized and purified mammalian tissue (e.g. bovine pericardium). The biomaterial effectively inhibits fibrosis, scar formation, and surgical adhesions, while also serving as a scaffold for recellularization of the tissue site.
Owner:SYNOVIS LIFE TECH
Stent covered with heterologous tissue
A covered stent assembly comprising a tubular, expandable stent having a metallic framework covered with a cylinder of biocompatible, non-thrombogenic expandable material, such as heterologous tissue. In a preferred embodiment, the metallic framework is positioned coaxially within a cylinder of bovine pericardial tissue. A catheter may be used to deliver the stent assembly to a desired region in the lumen of a patient. The metallic framework is then expanded to seat the assembly within the lumen.
Owner:AMNIS THERAPEUTICS
Heart valve prosthesis using different types of living tissue and method of fabricating the same
A heart valve prosthesis and a method of fabricating the same. The heart valve prosthesis uses a leaflet of pig pericardium or a leaflet of cattle pericardium, which has a suitable thickness according to the size of the valve, and a stent. The heart valve prosthesis is fabricated by placing a valve body over a Dacron body, binding the valve body to the Dacron body using stitching fiber, rolling the Dacron body into a cylindrical form such that the valve body is located inside, binding opposite edges of the Dacron body to each other using stitching fiber, and inserting the resultant structure into a stent, which is knitted using a shape memory alloy wire. The heart valve prosthesis is friendly to and is not rejected by human tissue, is free from deformation, and can be implanted using a non-invasive manner without incising the chest wall of a patient.
Owner:TAEWOONG MEDICAL CO LTD +1
Peritoneal regeneration with acellular pericardial patch
InactiveUS20050171616A1Low antigenicityLow immunogenicityHeart valvesTubular organ implantsGenipinPericardial patch
The invention discloses a method of using acellular bovine pericardia fixed with genipin as a surgical-repair material to fix an abdominal wall defect.
Owner:GP MEDICAL
Crosslinked bioprosthesis valve processing method
PendingCN109820625AImprove mechanical propertiesGood blood compatibilityHeart valvesCytotoxicityCalcification
The invention discloses a biovalve crosslinking method. The method includes introducing an unsaturated group to heterogeneous biological tissues such as porcine active valves, pig pericardia and bovine pericardia into through active groups on the biological tissues such as a carboxyl group, a hydroxyl group, an amino group and a sulfhydryl group reacting with an unsaturated group-containing compound to obtain an unsaturated group-modified biological tissue, and then obtaining a crosslinked biological tissue by radical polymerization. The biological tissue obtained by the crosslinking method has excellent collagen and elastin stability, blood compatibility, no cytotoxicity, good mechanical properties, anti-calcification capability and low inflammatory response.
Owner:SICHUAN UNIV
Novel artificial heart valve
ActiveCN102670332AReduce oppressionReduce the risk of conduction blockHeart valvesSurgical operationLeft ventricular size
The invention relates to a novel artificial heart valve which is implanted to replace a de-functionalized heart valve by surgical operation or vascular intervention. The novel artificial heart valve comprises a stent and a valve leaflet. The valve leaflet is made of a porcine or bovine pericardium or made of artificially synthesized high polymer material. The stent is composed of an inflow segment and an outflow segment and dilates by the aid of a balloon or by self-expanding. The inflow segment is provided with a self-expanding ring. Soft braided fabric is wrapped around a nitinol wire to form a soft surface. The valve leaflet is attached to the outflow segment to form a valve leaflet segment integrated with the outflow segment. The left-expanding ring has diameter larger than that of the valve leaflet segment and radial holding power larger than that of the valve leaflet segment. The inflow segment is flexibly connected with the valve leaflet segment. The metallic stent of the novel artificial heart valve need not enter a left ventricular outflow tract, and a left ventricle is internally fixed through the self-expanding ring. In addition, the self-expanding ring has smaller supporting power than the valve leaflet segment and the soft surface, so that stress of an endocardium of a left ventricular outflow tract can be lowered evidently, and risks caused by conduction block are reduced.
Owner:PEIJIA MEDICAL TECH SHANGHAI
Method for preparing absorbable and antibacterial guided tissue regeneration membrane for bone-like structure
ActiveCN104436318AFunction as a biological barrierImprove biological activitySurgerySodium phosphatesPhosphorylation
The invention provides a method for preparing an absorbable and antibacterial guided tissue regeneration membrane for a bone-like structure, and belongs to the field of biological medical materials. The method comprises the following steps: firstly, preparing a cell free bovine pericardial collagen fiber membrane by adopting a repeated freeze-thaw method and a surface active agent TritonX-100, or preparing a demineralized cell free collagen fiber membrane of a cattle lamellar bone by using a method of EDTA decalcification by using the surfactant TritonX-100; treating by using sodium trimetaphosphate to obtain a phosphorylated collagen fiber membrane; with the assistance of a direct-current electric field, mineralizing in agar hydrogel containing calcium and phosphate, thereby obtaining a mineralized collagen membrane with a bone-like structure with certain hardness; and finally soaking the mineralized collagen membrane into a minocyline solution, and preparing an antibacterial bone-like structured composite membrane structure by virtue of the characteristics of combined minocyline and hydroxyapatite. The guided tissue regeneration membrane provided by the invention has a bone-like structure, is capable of maintaining a bone defect space, is good in operation forming property and antibacterial property, and can be applied to clinical practice for bone defect remediation and reconstruction in periodontal departments, dental implant mediation and occlusalf surfaces.
Owner:李柏霖 +1
Swim bladder source biological valve material as well as preparation method and application thereof
ActiveCN108578781AHigh yieldGood thickness uniformityTissue regenerationProsthesisCross-linkCalcification
Owner:INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
Method for the treatment of biological tissue of animal or human origin, such as porcine, bovine pericardium or human cadaver heart valves, and biological tissue treated accordingly
ActiveUS20100317080A1Extended use timeTime of use of the tissue in the body can be drastically increased—inHeart valvesPharmaceutical delivery mechanismBiocompatibility TestingTreated animal
A method for treating glutardialdehyde-stabilised biological tissue of animal or human origin, such as porcine, bovine pericardium or human cadaver heart valves, provides a physical plasma treatment of the, in particular, collagen tissue for increasing the biocompatibility, cell colonisation and durability thereof.
Owner:PFM MEDICAL TITANIUM GMBH
Non-glutaraldehyde pre-installable dry biological valve material and preparation method and application thereof
ActiveCN111166938ASolve residual problemsSolution to short lifeTissue regenerationProsthesisGlycidyl methacrylateDouble bond
The present invention discloses a non-glutaraldehyde pre-installable dry biological valve material and a preparation method and an application thereof, and belongs to the technical field of medical materials. The preparation method comprises the following specific steps: a, decellularizing a pig or bovine pericardium material; b, soaking the decellularized pericardium in a glycidyl methacrylate oracrylic anhydride solution to introduce a carbon-carbon double bond structure; c, soaking the material in an aqueous solution of propyl methacrylate 3-sulfonate; d, adding an initiator for double bond polymerization cross-linking; e, using a mixed solution of carbodiimide and N-hydroxysuccinimide for cross-linking fixation; f, soaking the material in a polyphenol solution; and g, conducting storage with a micro-organism-inhibiting solution after rinsing or with an alcohol solution after dehydration drying. The preparation method can avoid problems of glutaraldehyde aldehyde group residues, easy calcification, and inability to protect elastin, at the same time, can effectively solve a problem that the dry valve material cannot be quickly flattened after being pressed and held, and potentially extends service life.
Owner:VENUS MEDTECH (HANGZHOU) INC
Heart valve prosthesis using different types of living tissue and method of fabricating the same
A heart valve prosthesis and a method of fabricating the same. The heart valve prosthesis uses a leaflet of pig pericardium (10) or a leaflet of cattle pericardium, which has a suitable thickness according to the size of the valve, and a stent. The heart valve prosthesis is fabricated by placing a valve body over a Dacron body (20), binding the valve body to the Dacron body using stitching fiber (30), rolling the Dacron body into a cylindrical form such that the valve body is located inside, binding opposite edges of the Dacron body to each other using stitching fiber, and inserting the resultant structure into a stent (60), which is knitted using a shape memory alloy wire. The heart valve prosthesis is friendly to and is not rejected by human tissue, is free from deformation, and can be implanted using a non-invasive manner without incising the chest wall of a patient.
Owner:TAEWOONG MEDICAL CO LTD +1
Chimeric tissue engineering bovine pericardium sheet
A chimeric tissue engineered bovine pericardium slice. The middle layer of the bovine pericardium is composed of three parts: cells, matrix, and fibers. The fibers maintain the biomechanical properties of the bovine pericardium, cells exist in the fiber voids, and form connections with the fibers through matrix components. The reasons for calcification, thrombus formation and decay in bovine pericardium that are commonly treated with glutaraldehyde in clinical practice are as follows: 1. Glutaraldehyde fixation can reduce immunogenicity to a certain extent, but there are still heterogeneous cell components remaining, which are cytotoxic , can induce immune rejection, and further cause tissue calcification and decay; 2, the middle space is small, it is difficult for body cells to grow in, and the epitope that induces rejection is exposed; 3, the residual aldehyde group is cytotoxic, and cells are difficult to Survival, low regenerative capacity. In order to effectively solve the above problems, on the basis of decellularization, matrix-like filling and cross-linking were performed to form chimeric tissue-engineered bovine pericardium slices.
Owner:李温斌
Method for the treatment of biological tissue of animal or human origin, such as porcine, bovine pericardium or human cadaver heart valves, and biological tissue treated accordingly
ActiveUS8426199B2Time of use of the tissue in the body can be drastically increased—inExtended use timeHeart valvesPharmaceutical delivery mechanismBiocompatibility TestingTreated animal
Owner:PFM MEDICAL TITANIUM GMBH
Composite cross-linked bioprosthetic valve and preparation method thereof
PendingCN113425910AIncrease elasticitySimple structureTissue regenerationProsthesisCell-Extracellular MatrixECM Protein
The application discloses a preparation method of a composite cross-linked bioprosthetic valve. The preparation method comprises the following steps: 1, treating a decellularized bioprosthetic valve with tannic acid; 2, treating the tannic acid treated bioprosthetic valve with neomycin; 3, treating the neomycin treated bioprosthetic valve with 5-riboflavin monophosphate under the condition of ultraviolet irradiation; and 4, rinsing to obtain the composite cross-linked bioprosthetic valve. The application further provides a composite cross-linked bioprosthetic valve. According to the preparation method of the composite cross-linked bioprosthetic valve and the prepared composite cross-linked bioprosthetic valve, which are provided by the application, photooxidation of riboflavin is adopted and synergic with tannic acid and neomycin to carry out cross-linking on decellularized bovine pericardium, so that the aim of cross-linking three main components of an extracellular matrix is fulfilled, and the bioprosthetic valve which is of a good extracellular matrix structure, has an excellent mechanical effect and heat shrinkage temperature, is thin in thickness, can have a wider application range and has good collagen enzymolysis resistance and elastic enzymolysis resistance can be obtained.
Owner:THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
Apparatus and method for processing bovine pericardium
InactiveUS20090247061A1Quality improvementProvide stabilityMeat processing plantsTissue regenerationSpherical formMaterials science
An apparatus for use in processing “raw” pericardium. The apparatus includes a mold having a generally hemispheroid dome and a support base upon which the mold is mounted. The hemispheroid dome has a diameter suitable for stretching a pericardium over the dome. Also, a method for processing “raw” pericardium. The method involves stretching raw pericardium over a mold such that the pericardium conforms to the shape of the mold and the mold stretches the pericardium. This is followed by separating at least some of the fat layer off the pericardial tissue layer where the pericardium is mounted over the mold and finally removing fat from the total pericardium surface.
Owner:COLLAGEN SOLUTIONS NZ LTD
Apparatus and method for processing bovine pericardium
InactiveUS7651387B2Quality improvementProvide stabilityMeat processing plantsTissue regenerationSpherical formMaterials science
An apparatus for use in processing “raw” pericardium. The apparatus includes a mold having a generally hemispheroid dome and a support base upon which the mold is mounted. The hemispheroid dome has a diameter suitable for stretching a pericardium over the dome. Also, a method for processing “raw” pericardium. The method involves stretching raw pericardium over a mold such that the pericardium conforms to the shape of the mold and the mold stretches the pericardium. This is followed by separating at least some of the fat layer off the pericardial tissue layer where the pericardium is mounted over the mold and finally removing fat from the total pericardium surface.
Owner:COLLAGEN SOLUTIONS NZ LTD
Optical tissue measurement
PendingCN112040994AProgramme controlPolarisation-affecting propertiesProsthetic valveCollagen fiber bundle
An optical method for determining collagen bundle orientation in bovine pericardium includes the use of a system having a light source which transmits light through a first polarizer, a tissue for making a prosthetic valve leaflet, and a second polarizer, where the light then illuminates a detector plate. The light that illuminates the detector plate is used to determine the orientation of collagen fiber bundles. The orientation of the collagen fiber bundles is used to determine where to cut the leaflet edges.
Owner:EDWARDS LIFESCIENCES CORP
Stentless bovine pericardium bioprosthetic valve manufactured through novel method
InactiveCN105167885ATime free from croppingShorten operation timeHeart valvesBioprosthetic valveMedicine
A stentless bovine pericardium bioprosthetic valve manufactured through a novel method comprises single valve leaflets. The contour lines of the edges of the single valve leaflets are parabolas. The parabolas are of four kinds according to ages and weights. The parabolas are formed by cutting in the mode that corresponding parabolas are generated according to information of ages and weights and single valve leaflets are formed by cutting the generated parabolas. When the number of the single parabolas is two or three, the single parabolas are connected through straight transition lines, and the span of the parabolas is defined, so that the cut bioprosthetic valve meets the requirement of patients. According to different ages and weights, the four parabolas are designed as the cutting tracks of the single valve leaflets, so that the cut tentless bovine pericardium bioprosthetic valve meets the requirements of patients of different ages and weights.
Owner:WUHAN VICKOR MEDICAL TECH CO LTD
Swim bladder-derived biological valve material and its preparation method and application
ActiveCN108578781BHigh yieldImprove thickness uniformityTissue regenerationProsthesisBioprosthetic valveSwim bladder
Owner:INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
Reagent combination and method for improving calcification resistance of bovine pericardial valve material
ActiveCN113984820AIncreased durabilityEffectively maintain mechanical propertiesMaterial analysis using wave/particle radiationPreparing sample for investigationDecellularizationBiological materials
The invention relates to the field of biological materials, in particular to a reagent combination and a method for improving the calcification resistance of a bovine pericardial valve material. On the basis of the existing glutaraldehyde cross-linked decellularized bovine pericardium, decellularization and aldehyde group sealing are carried out, and meanwhile, elastin, a glycosaminoglycan cross-linking agent and a calcium ion inhibitor are supplemented for treatment. Compared with existing glutaraldehyde crosslinking, experiments prove that the calcification resistance can be improved on the basis of effectively maintaining the mechanical property, and the durability of the valve material is improved.
Owner:THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
Mitral Stent
PendingUS20220257374A1Avoid stickingPrevent over-boostingStentsHeart valvesEngineeringMechanical engineering
The invention relates to a self-expendable stent for placement at a mitral annulus that is self-expandable from an undeployed state to a deployed state comprising a stent frame having at least a first section and a second section arranged at a longitudinal axis of the stent, wherein the stent frame is formed by a plurality of endless arms, the arms being connected to one another at connection points forming a web-like structure with diamond-shaped cells; a dry valve made out of bovine pericardium arranged at least at the second section of the stent with the dry bovine pericardium being configured to be rehydrated with a solution, a skirt surrounding the dry valve and comprising at least one of bovine pericardium and polyester, and wherein, in the expanded state, a maximum outer diameter of the first section is larger than a maximum outer diameter of the second section, and wherein at least at a transition between the first section and the second section some of the endless arms extend outwardly beyond the web-like structure to form a hook, which faces the first section.
Owner:PF PROD FEATURES GMBH
Microporous decellularized bovine pericardium matrix capable of slow release of bio-active factors
InactiveCN108635623APreserve 3D structureRetain mechanical propertiesTissue regenerationProsthesisFreeze thawingMicrometer
The invention provides microporous decellularized bovine pericardium matrix capable of slow release of bio-active factors. The matrix is characterized in that the microporous decellularized bovine pericardium matrix capable of slow release of the bio-active factors has a microporous structure and the bio-active factors adhering to the surface of the microporous structure,the microporous structureis spongy,microporous of the microporous structure is circular or elliptical,the microporous decellularized bovine pericardium matrix capable of slow release of the bio-active factors has different microporous sizes,and the largest diameter is up to 50 micrometers,wherein the bio-active factors are growth factors with biological activity; according to the microporous decellularized bovine pericardium matrix capable of slow release of the bioactive factors,bovine pericardium is placed in a non-ionic detergent buffer under a vacuum condition,and after multiple freeze thawing is conducted,the bovine pericardium is vibrated and washed in the non-ionic detergent buffer,sterile deionized water and a phosphate solution in turn,and finally is immersed in a bio-active factor agarose material to obtain the matrix.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Valved conduit device for aortic root
PendingCN107320219AShorten operation timeGood surgery timeHeart valvesBlood vesselsAscending aortaBioprosthetic valve
The invention relates to a valved conduit device for an aortic root. A transplanting conduit comprises an ascending aorta replacement tube and an aortic sinus replacement portion. A bioprosthetic valve comprises a bovine pericardium and a nickel-titanium support, wherein the nickel-titanium support is located outside the bovine pericardium, and the bovine pericardium is wrapped with the nickel-titanium support and fixed through the nickel-titanium support; the bioprosthetic valve is arranged in the aortic sinus replacement portion through an opening device, and is opened through the opening device to be closely attached to the inner wall of the aortic sinus replacement portion, the height of the nickel-titanium support is higher than the height of the aortic sinus replacement portion, and the nickel-titanium support is divided into an ascending aorta section and an aortic sinus section. According to the valved conduit device for the aortic root, the operation time of the aortic root is shortened, the biocompatibility is improved through the bioprosthetic valve, and the side effects brought by mechanical valve anticoagulation is reduced.
Owner:SECOND AFFILIATED HOSPITAL SECOND MILITARY MEDICAL UNIV
A non-glutaraldehyde prepackaged dry biological valve material and its preparation method and application
ActiveCN111166938BSolve residual problemsSolution to short lifeTissue regenerationProsthesisGlycidyl methacrylateDouble bond
The present invention discloses a non-glutaraldehyde pre-installable dry biological valve material and a preparation method and an application thereof, and belongs to the technical field of medical materials. The preparation method comprises the following specific steps: a, decellularizing a pig or bovine pericardium material; b, soaking the decellularized pericardium in a glycidyl methacrylate oracrylic anhydride solution to introduce a carbon-carbon double bond structure; c, soaking the material in an aqueous solution of propyl methacrylate 3-sulfonate; d, adding an initiator for double bond polymerization cross-linking; e, using a mixed solution of carbodiimide and N-hydroxysuccinimide for cross-linking fixation; f, soaking the material in a polyphenol solution; and g, conducting storage with a micro-organism-inhibiting solution after rinsing or with an alcohol solution after dehydration drying. The preparation method can avoid problems of glutaraldehyde aldehyde group residues, easy calcification, and inability to protect elastin, at the same time, can effectively solve a problem that the dry valve material cannot be quickly flattened after being pressed and held, and potentially extends service life.
Owner:VENUS MEDTECH (HANGZHOU) INC
Pancreas stump protector
InactiveCN104224416BSimple structureEasy to useNon-surgical orthopedic devicesIntestinal submucosaEngineering
A protective cover for the stump of the pancreas, the protective cover is in the shape of a truncated cone, the inner end of the protective cover is closed, and the outer end is open, the protective cover includes an inner cover and an outer cover, and the inner cover is made of polypropylene material Made, the jacket is made of polytetrafluoroethylene material. Or the material of the protective sheath is biomaterial decellularized small intestinal submucosal matrix or pig and bovine pericardium or bovine pericardium. The opening end of the protective cover is bent inwardly to have a folded edge, and a medical nylon rope is arranged inside the folded edge, and the medical nylon rope is drawn out from the folded edge, and the medical nylon rope is tightened so that the folded edge is tightened. The snare of the hem is tightened with a pre-knot similar to the hem for easy laparoscopic or da Vinci surgical pancreatic surgery application. The beneficial effect of the present invention is: it is simple in structure, convenient to use, and remarkable in effect, and can isolate the stump of pancreas from the environment of gastric cavity or intestinal cavity, and can effectively protect the stump of pancreas, thereby preventing the stump of pancreas from being damaged by gastric juice or intestinal juice. Corrosion, causing complications such as fatal hemorrhage.
Owner:洪德飞 +2
Aortic Stent
PendingUS20220257834A1Avoid stickingPrevent over-boostingStentsAnnuloplasty ringsAortic valve ringBiomedical engineering
The invention relates to a stent for placement at an aortic annulus that is expandable from an undeployed state to a deployed state comprising a stent frame having rows of cells with a proximal section and a distal section at a longitudinal axis of the stent, the stent frame being formed by a plurality of arms, the arms being connected to one another at connection points, and wherein the plurality of arms forms a plurality of diamond-shaped stent cells, in particular the rows of cells, formed of vertices at said connection points between the arms, a dry valve made out bovine pericardium arranged at least at the distal section of the stent with the dry bovine pericardium being configured to be rehydrated with a solution, a skirt surrounding the dry valve and comprising at least one of bovine pericardium and polyester, and one or more eyelets arranged at a distal end of some of the arms, with the eyelets being configured to fix the valve to the stent frame.
Owner:PF PROD FEATURES GMBH
Self-expanding stent and stent set
PendingCN113423363APrecise positioningRelieve pressureVenous valvesSuperior vena cavaBiomedical engineering
Owner:PF PROD FEATURES GMBH
A new type of artificial heart valve
ActiveCN102670332BReduce oppressionReduce the risk of conduction blockHeart valvesSurgical operationLeft ventricular size
Owner:PEIJIA MEDICAL TECH SHANGHAI
Self-expandable stent and set of stents
PendingUS20220151775A1Shorten treatment timeMortality rate is decreasedVenous valvesPolyesterSuperior vena caval
A self-expandable stent has a dry valve made of bovine pericardium arranged at a proximal end thereof, a skirt surrounding the dry valve at the proximal end of the stent and made of one of bovine pericardium and polyester. The dry valve is configured to be rehydrated when placed in contact with a solution, and the stent includes eyelets arranged at the proximal end of the stent for fixing the stent at a point of interest, with the point of interest being one of the vena cava superior and the vena cava inferior.
Owner:PF PROD FEATURES GMBH
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