36 results about "Bovine pericardium" patented technology

A covered stent assembly comprising a tubular, expandable stent having a metallic framework covered with a cylinder of biocompatible, non-thrombogenic expandable material, such as heterologous tissue. In a preferred embodiment, the metallic framework is positioned coaxially within a cylinder of bovine pericardial tissue. A catheter may be used to deliver the stent assembly to a desired region in the lumen of a patient. The metallic framework is then expanded to seat the assembly within the lumen.

The invention discloses a biovalve crosslinking method. The method includes introducing an unsaturated group to heterogeneous biological tissues such as porcine active valves, pig pericardia and bovine pericardia into through active groups on the biological tissues such as a carboxyl group, a hydroxyl group, an amino group and a sulfhydryl group reacting with an unsaturated group-containing compound to obtain an unsaturated group-modified biological tissue, and then obtaining a crosslinked biological tissue by radical polymerization. The biological tissue obtained by the crosslinking method has excellent collagen and elastin stability, blood compatibility, no cytotoxicity, good mechanical properties, anti-calcification capability and low inflammatory response.

The invention relates to a novel artificial heart valve which is implanted to replace a de-functionalized heart valve by surgical operation or vascular intervention. The novel artificial heart valve comprises a stent and a valve leaflet. The valve leaflet is made of a porcine or bovine pericardium or made of artificially synthesized high polymer material. The stent is composed of an inflow segment and an outflow segment and dilates by the aid of a balloon or by self-expanding. The inflow segment is provided with a self-expanding ring. Soft braided fabric is wrapped around a nitinol wire to form a soft surface. The valve leaflet is attached to the outflow segment to form a valve leaflet segment integrated with the outflow segment. The left-expanding ring has diameter larger than that of the valve leaflet segment and radial holding power larger than that of the valve leaflet segment. The inflow segment is flexibly connected with the valve leaflet segment. The metallic stent of the novel artificial heart valve need not enter a left ventricular outflow tract, and a left ventricle is internally fixed through the self-expanding ring. In addition, the self-expanding ring has smaller supporting power than the valve leaflet segment and the soft surface, so that stress of an endocardium of a left ventricular outflow tract can be lowered evidently, and risks caused by conduction block are reduced.

The invention provides a method for preparing an absorbable and antibacterial guided tissue regeneration membrane for a bone-like structure, and belongs to the field of biological medical materials. The method comprises the following steps: firstly, preparing a cell free bovine pericardial collagen fiber membrane by adopting a repeated freeze-thaw method and a surface active agent TritonX-100, or preparing a demineralized cell free collagen fiber membrane of a cattle lamellar bone by using a method of EDTA decalcification by using the surfactant TritonX-100; treating by using sodium trimetaphosphate to obtain a phosphorylated collagen fiber membrane; with the assistance of a direct-current electric field, mineralizing in agar hydrogel containing calcium and phosphate, thereby obtaining a mineralized collagen membrane with a bone-like structure with certain hardness; and finally soaking the mineralized collagen membrane into a minocyline solution, and preparing an antibacterial bone-like structured composite membrane structure by virtue of the characteristics of combined minocyline and hydroxyapatite. The guided tissue regeneration membrane provided by the invention has a bone-like structure, is capable of maintaining a bone defect space, is good in operation forming property and antibacterial property, and can be applied to clinical practice for bone defect remediation and reconstruction in periodontal departments, dental implant mediation and occlusalf surfaces.

The invention relates to a swim bladder source biological valve material as well as a preparation method and an application thereof. The preparation method comprises the following steps: cutting a swim bladder and conducting decellularization treatment on the swim bladder, so that a decellularized swim bladder is obtained; conducting immobilized cross-linking on the decellularized swim bladder, and rinsing the decellularized swim bladder obtained from cross-linking, so that the swim bladder source biological valve material is obtained. In comparison with existing bovine pericardium source biological valve materials, the swim bladder source biological valve material provided by the invention is smooth in both sides and good in uniformity of material thickness, and the swim bladder source biological valve material is nearly free from fat and other adhesion tissues, so that a raw material processing course becomes simpler to operate, and a yield of preparing biological valves from swim bladders is improved; and the swim bladder source biological valve material is equivalent with the bovine pericardium source biological valve materials in mechanical performance, however anti-calcification performance of the swim bladder material is much better than that of the bovine pericardium material, so that a shortcoming of bovine pericardium biological valves which are insufficient in service life can be overcome, and problems of the existing bovine pericardium source biological valve materials which are poor in durability, easy to cause calcification and the like can be solved.

A method for treating glutardialdehyde-stabilised biological tissue of animal or human origin, such as porcine, bovine pericardium or human cadaver heart valves, provides a physical plasma treatment of the, in particular, collagen tissue for increasing the biocompatibility, cell colonisation and durability thereof.

A chimeric tissue engineered bovine pericardium slice. The middle layer of the bovine pericardium is composed of three parts: cells, matrix, and fibers. The fibers maintain the biomechanical properties of the bovine pericardium, cells exist in the fiber voids, and form connections with the fibers through matrix components. The reasons for calcification, thrombus formation and decay in bovine pericardium that are commonly treated with glutaraldehyde in clinical practice are as follows: 1. Glutaraldehyde fixation can reduce immunogenicity to a certain extent, but there are still heterogeneous cell components remaining, which are cytotoxic , can induce immune rejection, and further cause tissue calcification and decay; 2, the middle space is small, it is difficult for body cells to grow in, and the epitope that induces rejection is exposed; 3, the residual aldehyde group is cytotoxic, and cells are difficult to Survival, low regenerative capacity. In order to effectively solve the above problems, on the basis of decellularization, matrix-like filling and cross-linking were performed to form chimeric tissue-engineered bovine pericardium slices.

An apparatus for use in processing “raw” pericardium. The apparatus includes a mold having a generally hemispheroid dome and a support base upon which the mold is mounted. The hemispheroid dome has a diameter suitable for stretching a pericardium over the dome. Also, a method for processing “raw” pericardium. The method involves stretching raw pericardium over a mold such that the pericardium conforms to the shape of the mold and the mold stretches the pericardium. This is followed by separating at least some of the fat layer off the pericardial tissue layer where the pericardium is mounted over the mold and finally removing fat from the total pericardium surface.

An optical method for determining collagen bundle orientation in bovine pericardium includes the use of a system having a light source which transmits light through a first polarizer, a tissue for making a prosthetic valve leaflet, and a second polarizer, where the light then illuminates a detector plate. The light that illuminates the detector plate is used to determine the orientation of collagen fiber bundles. The orientation of the collagen fiber bundles is used to determine where to cut the leaflet edges.

A stentless bovine pericardium bioprosthetic valve manufactured through a novel method comprises single valve leaflets. The contour lines of the edges of the single valve leaflets are parabolas. The parabolas are of four kinds according to ages and weights. The parabolas are formed by cutting in the mode that corresponding parabolas are generated according to information of ages and weights and single valve leaflets are formed by cutting the generated parabolas. When the number of the single parabolas is two or three, the single parabolas are connected through straight transition lines, and the span of the parabolas is defined, so that the cut bioprosthetic valve meets the requirement of patients. According to different ages and weights, the four parabolas are designed as the cutting tracks of the single valve leaflets, so that the cut tentless bovine pericardium bioprosthetic valve meets the requirements of patients of different ages and weights.

The invention relates to a self-expendable stent for placement at a mitral annulus that is self-expandable from an undeployed state to a deployed state comprising a stent frame having at least a first section and a second section arranged at a longitudinal axis of the stent, wherein the stent frame is formed by a plurality of endless arms, the arms being connected to one another at connection points forming a web-like structure with diamond-shaped cells; a dry valve made out of bovine pericardium arranged at least at the second section of the stent with the dry bovine pericardium being configured to be rehydrated with a solution, a skirt surrounding the dry valve and comprising at least one of bovine pericardium and polyester, and wherein, in the expanded state, a maximum outer diameter of the first section is larger than a maximum outer diameter of the second section, and wherein at least at a transition between the first section and the second section some of the endless arms extend outwardly beyond the web-like structure to form a hook, which faces the first section.

The invention provides microporous decellularized bovine pericardium matrix capable of slow release of bio-active factors. The matrix is characterized in that the microporous decellularized bovine pericardium matrix capable of slow release of the bio-active factors has a microporous structure and the bio-active factors adhering to the surface of the microporous structure,the microporous structureis spongy,microporous of the microporous structure is circular or elliptical,the microporous decellularized bovine pericardium matrix capable of slow release of the bio-active factors has different microporous sizes,and the largest diameter is up to 50 micrometers,wherein the bio-active factors are growth factors with biological activity; according to the microporous decellularized bovine pericardium matrix capable of slow release of the bioactive factors,bovine pericardium is placed in a non-ionic detergent buffer under a vacuum condition,and after multiple freeze thawing is conducted,the bovine pericardium is vibrated and washed in the non-ionic detergent buffer,sterile deionized water and a phosphate solution in turn,and finally is immersed in a bio-active factor agarose material to obtain the matrix.

The invention relates to a valved conduit device for an aortic root. A transplanting conduit comprises an ascending aorta replacement tube and an aortic sinus replacement portion. A bioprosthetic valve comprises a bovine pericardium and a nickel-titanium support, wherein the nickel-titanium support is located outside the bovine pericardium, and the bovine pericardium is wrapped with the nickel-titanium support and fixed through the nickel-titanium support; the bioprosthetic valve is arranged in the aortic sinus replacement portion through an opening device, and is opened through the opening device to be closely attached to the inner wall of the aortic sinus replacement portion, the height of the nickel-titanium support is higher than the height of the aortic sinus replacement portion, and the nickel-titanium support is divided into an ascending aorta section and an aortic sinus section. According to the valved conduit device for the aortic root, the operation time of the aortic root is shortened, the biocompatibility is improved through the bioprosthetic valve, and the side effects brought by mechanical valve anticoagulation is reduced.

A self-expandable stent has a dry valve made of bovine pericardium arranged at a proximal end thereof, a skirt surrounding the dry valve at the proximal end of the stent and made of one of bovine pericardium and polyester. The dry valve is configured to be rehydrated when placed in contact with a solution, and the stent includes eyelets arranged at the proximal end of the stent for fixing the stent at a point of interest, with the point of interest being one of the vena cava superior and the vena cava inferior.

The invention discloses a method for increasing stability of bioprosthetic heart valve glycosaminoglycan. The method comprises the following processes: Modification of pig or bovine pericardium with p-hydroxyphenylpropionic acid or p-hydroxyphenylethylamine, modification of neomycin sulfate with p-hydroxyphenylpropionic acid, and initiation of enzyme cross-linking under conditions of horseradish peroxidase and hydrogen peroxide. A phenolic hydroxyl group can be introduced into the p-hydroxyphenylpropionic acid modified neomycin sulfate, and horseradish peroxidase and hydrogen peroxide will achieve chemical crosslinking of the phenolic hydroxyl group. The method provided by the invention can raise the glycosaminoglycan stability and anti-calcification performance of bioprosthetic heart valve and potentially prolong its service life.