32 results about "Endocardium" patented technology

The invention provides a four-dimensional cardiac function imaging method and device based on a biological magnetic signal. The method comprises the following steps: acquiring a magnetocardiogram signal of a to-be-detected object and dynamic structure information of a target trunk part in a full cardiac cycle; wherein the target trunk part at least comprises double lungs, a trunk, a heart cavity of the trunk and a pericardium structure, and the dynamic structure information comprises a contour structure and a multi-frame dynamic image; performing spatial registration on the dynamic structure information and the sensor for acquiring the magnetocardiogram signal to obtain coordinates of the sensor in a coordinate system of the dynamic structure information; according to the dynamic structure information, the coordinate of the sensor and the magnetocardiogram signal, calculating and reconstructing cardiac electrical excitation activity to obtain a calculation and reconstruction result; and converting the calculation reconstruction result into a four-dimensional visual image. According to the method, heart magnetic imaging and heart movement are combined, on the basis of obtained dynamic structure information and heart magnetic signals, the characteristics of biological magnetic signals are fully utilized, and the signal processing technology is integrated through space registration, so that accurate reconstruction of four-dimensional representation of the heart and visual display of functional activities are realized; therefore, the obtained four-dimensional visual image can completely represent the dynamic electrophysiological activities of the whole heart (including epicardium, endocardium and intrawall tissues) in a cardiac cycle, and a technical scheme with different concepts is provided for non-invasive imaging of cardiac electrical excitation activities.

The invention discloses a recombinant adeno-associated virus vector for targeted delivery of VEGF-C (vascular endothelial growth factor-C) and application of the recombinant adeno-associated virus vector in promoting endocardial differentiation to treat coronary heart disease. The rAAV vector comprises transgene for coding VEGF-C protein or VEGF-C protein functional variant and a tissue-specific promoter operably connected to the transgene, wherein the tissue specific promoter is capable of driving the transgene to be specifically expressed in the heart endothelial cells. According to the treatment method developed by the invention, specific expression of the Vegfc gene in the heart is driven by using an ICAM2 promoter with targeting to endothelial cells, and a remarkable curative effect is shown in a myocardial infarction model mouse. The therapeutic scheme provides a new effective strategy for intervention and treatment of myocardial infarction and chronic heart failure, and has the advantages of high safety, long gene expression duration, extremely low immune response to a host and the like.

A force sensor assembly for use in the field of cardiac ablation, for the ablation-based treatment of atrial fibrillation and other cardiac arrhythmias. Various embodiments of the disclosure are directed to a catheter distal force sensor for measuring catheter tip-to-endocardial wall force by measuring displacement of irradiation patterns sensed with a two-dimensional imaging sensor. The disclosed devices sense an array of irradiation pattern characteristics, including changes in size and location of irradiation shapes of the irradiation pattern. In some embodiments, multiple irradiation spots are tracked with the two-dimensional imaging sensor to infer the components of a reaction force vector acting the force sensor assembly. The disclosed force is designed to accommodate typical catheter tip dimensions, the outer diameter of these usually being less than or equal to 3 mm.

The utility model provides a novel cardiac pacemaker lead fixing device belongs to medical appliance technical field, this novel cardiac pacemaker lead fixing device, include: lead body, the inside of lead body is equipped with thin metal wire, and the surface is provided with rotating handle. The utility model: the lead body is passed through the protection sheath pipe, and the anchor head end structure of lead body one end is moved to the inside of heart, until the main helical silk of nickel titanium alloy is made on the anchor head end and is fixed with the outer layer of myocardium, further adjusts the rotating handle on the surface of lead body to make the electrode end continue to move, the diameter between a plurality of inner layer's auxiliary micro helical silk changes in the process of rotating to drive a plurality of anchor block rotation and move and pass through endocardium, cooperate a plurality of anchor block surface's anchor hook and enhance the stability of lead body fixed, realize the purpose of anchor head end grading anchor operation.

The invention discloses a biomarker combination for predicting PCI postoperative LVR of an STEMI patient and application of the biomarker combination, and belongs to the technical field of biology. The research discovers that in a left ventricular remodeling (LVR) group and a non-left ventricular remodeling group after percutaneous coronary intervention (PCI) of a patient suffering from acute ST segment elevation type myocardial infarction (STEMI), a left ventricular endocardial lower myocardial overall longitudinal strain (GLS internal) value, a lung B-line integral, a serum sFRP5 level and Apelin-13 show significant differences. Through combined prediction analysis, it is found that the GLS internal value, the lung B-line integral, the serum sFRP5 and the Apelin-13 have excellent prediction performance on whether the LVR occurs after the PCI operation of the STEMI patient or not, high-risk groups, suffering from the LVR after the PCI operation, of the STEMI patient can be accurately and efficiently recognized, intervention is conducted as soon as possible, and the life quality of the patient is expected to be improved.

This invention discloses a method for preparing a simulated heart model and the simulated heart model itself. The method for preparing the simulated heart model includes: dividing a digital heart model into two parts along its coronal plane; preparing corresponding molding molds according to the structural characteristics of the two parts, each molding mold including an outer molding mold and an inner cavity molding mold; applying silicone to the molding surfaces of the outer molding mold and the inner cavity molding mold to form the endocardium and epicardium; applying silicone to the portion of the inner cavity molding mold used for molding the valve to form the valve; assembling the outer molding mold and the inner cavity molding mold to form a cavity; sequentially injecting silicone of corresponding hardness into the regions of the cavity used for molding the atrial myocardium, interatrial septal myocardium, ventricular myocardium, and interventricular septal myocardium to form heart model halves; and bonding the heart model halves corresponding to the two molding molds together to obtain the simulated heart model.

A system for sensing multiple local electric voltages from endocardial surface of a heart, includes: an elongate tubular member having a lumen, a proximal end and a distal end; a plurality of flexible splines; an anchor for securably affixing the proximal portions of the splines, where the anchor is securably affixed within the lumen of the elongate tubular member at the distal end of the elongate tubular member; and a metallic tip for securably affixing the distal portions of the splines.

A needle-injection catheter includes a catheter body having a distal end, a proximal end, a stiff proximal portion, a flexible distal portion, and a delivery lumen extending therethrough. In a first embodiment, a straight injection needle extends coaxially from a distal tip of the flexible portion of the catheter body, and a plurality of penetration limiting elements positioned circumferentially about a base of the straight injection needle and configured to fold radially inwardly against a shaft of the needle when constrained in a tubular lumen and to extend radially outwardly when unconstrained. In a second embodiment, a helical needle extends from the distal tip of the flexible portion of the catheter body. The helical needle has at least one helical delivery lumen connected to receive an injectable substance from the delivery lumen of the catheter body.

A method of calculating an atrial wall thickness through a device including a processor and a memory according to an embodiment of the present disclosure may include (a) receiving image data for a patient's atrium as input data, (b) calculating endocardial and epicardial borders corresponding to starting and ending points of the atrial wall thickness from the received input data, and (c) calculating the patient's atrial wall thickness using the calculated endocardial and epicardial borders, wherein the image data for the patient's atrium received in the step (a) is a plurality of mask label image data for respective tomographic images of the patient's atrium acquired from computed tomography (CT) scans for the patient's atrium, and the mask label image data is data in which one or more pixels corresponding to an atrial wall region including the patient's atrium and an inner region of the atrium, other regions within the patient's heart disposed around the patient's atrium, and regions other than the patient's heart, respectively, are assigned with labels having different numerals for the respective regions.

A catheter utilizes a distal electrode array configured for quantification of endocardial or epicardial propagation velocity, with electrodes defining approximately equilateral triangles, such that the calculated velocity can be approximated regardless of the wave front direction. The distal electrode array can also include resilient splines carrying the electrodes such that the splines can deform to ensure contact between the electrodes and the heart tissue. Additionally, the electrodes of the distal electrode array can be individually addressable. Bipolar ablation lines or boxes can also be implemented using two parallel catheters at the endocardium and at the epicardium. Certain configurations include one or more distal electrode arrays of sufficient size to span an entire ventricular tachycardia (VT) circuit. The catheter may also be configured to detect block lines by pacing from edge pacing electrodes of the distal electrode array, and / or to detect fiber orientation by pacing from several edge pacing electrodes.

The invention discloses a composite electrophysiological positioning and contact force measuring method and system. The method comprises the following steps: constructing a three-dimensional space non-uniform electric field; through an optical trap structure integrated at the tip of the catheter, preset charged particles are captured, and the intensity of a vector electric field is sensed; acquiring a displacement signal of the particle, and decoupling the displacement signal into a three-axis electric field component; converting the electric field component into a three-dimensional space position of the tip of the catheter; three-dimensional contact force generated by contact between the catheter and the endocardium is detected through an optical fiber sensing structure arranged at the tip end of the catheter, and measurement is carried out through optical parameter changes of the optical fiber sensing structure. The system comprises a three-dimensional non-uniform electric field construction module; the composite conduit includes: a vector electric field measurement unit; the three-dimensional contact force measuring unit comprises at least one FBG (Fiber Bragg Grating) or F-P (Fabry-Perot) cavity arranged on the optical fiber; and a signal processing module. The principle is innovative, and a three-dimensional electrophysiological positioning composite three-dimensional contact force measurement scheme with micron-level positioning precision, low cost and open compatibility is provided.

An ultrasound imaging system computes real time physiological parameters from measurements of anatomical features in ultrasound image data using a neural network to identify the location of the anatomical features. In one embodiment, cardiac parameters are computed from endocardial wall tracings in M-mode ultrasound image data that are identified by the neural network.

The invention relates to the technical field of heart electrophysiological information analysis, in particular to a data analysis system and method based on three-dimensional heart modeling, and the method comprises the steps: obtaining a heart three-dimensional medical image, reconstructing a heart muscle grid, constructing a public heart coordinate, and dividing the surface of an endocardium into a plurality of endocardium partitions; fusing catheter mapping points and local potential waveforms on the geometric model, establishing a three-dimensional electrophysiological propagation model consistent with individual anatomy, and forming heart digital twinning; a structural network and a propagation network are constructed based on endocardium partition, an excitation propagation path and a turn-back risk are analyzed, and influences of different targets on the turn-back risk are compared through virtual ablation simulation, so that a quantitative basis is provided for myocardial ablation target selection and intervention strategy formulation.

The subject of the invention is a device (1) for measuring and recording the squeezing force of the heart ventricle exerted by the inner surface of the heart ventricle wall, which device (1) comprises a stabilizing system (2) with at least one measuring arm (3) extending therefrom, on which a sensor (9) is placed. The device (1) has a spatial design adapted to the interior of the left ventricle, allowing for multi-point contact with the endocardial surface. The subject of the invention is also a computer-implemented method of measuring and recording the squeezing force measured using a device (1) for measuring and recording the squeezing force of the heart ventricle.

VfA cardiac therapy uses an implantable medical device or system. The implantable medical device includes a tissue-piercing electrode implanted in the basal and / or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body. The device may include a right atrial electrode, a right atrial motion detector, or both. The device may be implanted completely within the patient's heart or may use one or more leads to implant electrodes in the patient's heart. The device may be used to provide cardiac therapy, including single or multiple chamber pacing, atrioventricular synchronous pacing, asynchronous pacing, triggered pacing, cardiac resynchronization pacing, or tachycardia-related therapy. A separate medical device may be used to provide some functionality for cardiac therapy, such as sensing, pacing, or shock therapy.

Systems, devices, and methods for electroporation ablation therapy are disclosed, with the system including a pulse waveform signal generator for medical ablation therapy, and an endocardial ablation device includes an inflatable member and at least one electrode for focal ablation pulse delivery to tissue. The signal generator may deliver voltage pulses to the ablation device in the form of a pulse waveform. The system may include a cardiac stimulator for generation of pacing signals and for sequenced delivery of pulse waveforms in synchrony with the pacing signal.

Provided by the present disclosure are a boundary element-based three-dimensional mapping method, system and apparatus, as well as a device and a medium. The method includes the following steps: acquiring a three-dimensional endocardium model, electrode potential data collected by an electrode probe in a cardiac chamber, and position data of the electrode probe collected by a three-dimensional spatial positioning system; performing boundary element discretization processing of the endocardium using a normal vector in geometric vector data, the position data and a preset electrostatic relationship of an intracardiac potential to determine a numerical relationship equation after boundary element discretization; solving an endocardial potential by inverse operation based on the numerical relationship equation, the position data and the electrode potential data; and determining an endocardial charge density on the endocardium according to the endocardial potential data and a preset charge density algorithm, and displaying the endocardial charge density in real time.

This invention discloses a multifunctional non-contact three-dimensional cardiac electrophysiological mapping system based on intracardiac ultrasound (ICE), comprising an ICE system, an ultrasound host, an ECG signal acquisition system, and a three-dimensional spatial positioning system. By adjusting the position and imaging angle of the ICE probe, it continuously acquires cardiac ultrasound signals, as well as heartbeat and respiratory signals, to synchronously acquire ultrasound signals at different cardiac cycles. Cross-correlation calculations are performed on the continuous ultrasound signals acquired at various spatial locations to obtain the three-dimensional cardiac excitation conduction sequence and maximum amplitude distribution within a cardiac cycle. This system can perform both intracardiac ultrasound imaging and non-contact three-dimensional electrophysiological mapping, reducing the use of catheters and medical costs in traditional contact electrophysiological interventional procedures, simplifying surgical operations, and improving surgical safety. Furthermore, it can simultaneously map the endocardium, intramyocardium, and epicardium, enabling more precise surgical planning and possessing significant clinical value.

The invention discloses a primary endocardial endothelial cell extraction method suitable for cardiovascular disease research. Non-specific components are removed through directional sampling, enzyme digestion and mechanical dispersion of an endocardium microscopic spatula and in combination with a CD31 positive selection and CD36 negative selection combined strategy; after culture, Npr3 backtracking, functional verification and passage limitation (less than or equal to P2) are used for controlling quality. According to the method, the cells with the purity of 80-90%, the motility rate of more than or equal to 85% and stable Npr < 3 + > proportion can be obtained, and compared with a traditional method, the method has the advantages in the aspects of material taking specificity, function fidelity and repeatability. The invention provides a reliable cell source for cardiovascular disease research and transformation application.

A method for localizing the source of an arrhythmia within a heart wall is disclosed. The method involves accessing an indication of the source location of the arrhythmia within the endocardium. A normal vector is generated that is normal to the endocardium at the source location in the direction of the epicardium layer. An activation vector indicating the direction of electrical force of the heart during an initial stage of depolarization is determined. The depth angle between the normal vector and the activation vector is determined, and the depth of the source location within the heart wall is indicated based on a depth angle.

The invention provides an ablation needle assembly and an ablation system. The ablation needle comprises an electrode needle main body and an ablation handle connected with the near end of the electrode needle main body, the electrode needle main body is movably arranged in the outer sleeve in a penetrating manner, and a limiting part is arranged on the outer sleeve to limit the ablation direction of the ablation needle. The far end face of the outer sleeve is connected with a conductive section which extends towards the side away from the outer sleeve in the axial direction of the outer sleeve, and the limiting part is one or more insulating layers which are arranged in the axial direction of the conductive section and partially cover the conductive section. Or the limiting part is one or a plurality of insulating strips which are axially connected to part of the far-end end face of the outer sleeve along the outer sleeve, the plurality of insulating strips are arranged at intervals around the axis of the outer sleeve, and a hollow part is formed on the far side of the part, which is not connected with the insulating strips, of the far-end end face of the outer sleeve. When the ablation needle assembly is applied to ablation treatment of HCM, the ablation direction of the ablation needle can be kept away from the thickness direction of the ventricular septum, and therefore the situation that the ablation needle ablates in the thickness direction of the ventricular septum and penetrates through the endocardium is avoided.

A system for VT localization comprises an electrocardiograph (ECG) device for detecting electrical signals of a ventricular fibrillation event in a patient and producing ECG data, a localizer, and a display device. The localizer comprises a memory and a processor, the memory storing a model and one or more parameters of the model. The memory further stores instructions that when executed by the processor cause the processor to receive the ECG data, and generate a determination indicating whether a detected VT signal arose from an endocardial surface or epicardial surface based on signal averaged waveform for each of the leads. The display device is configured to output the determination, which can also be communicated to follow-on provider systems.

This invention discloses a dilator for three-dimensional atrial septal puncture, comprising a tube body including a central chamber, a distal end, and a proximal end. The distal end of the tube body has a curved structure, and a cutting end is provided at the distal end of the curved structure. The dilator of this invention allows the position of the needle tip to be accurately displayed in real time in a three-dimensional system, and eliminates the risk of needle tip damage to the superior vena cava and endocardial tissue in other three-dimensional puncture methods.

The invention discloses a magnetic resonance heart left ventricle automatic segmentation method based on a two-stage active contour model. The method comprises the following steps: (1) image acquisition; (2) image preprocessing: carrying out normalization processing on the image obtained in the step (1) in a range of [0, 255]; (3) image contour initialization: all functions comprise an image binarization function, a connection component marking algorithm and an ROI selection algorithm which are executed by adopting prior information of a left ventricular structure, and a left ventricular region contour is obtained through repeated iteration; (4) two-stage segmentation: segmenting the left ventricle into two stages; the first stage is endocardium segmentation, and the second stage is epicardium segmentation; and (5) post-processing: operating the endocardium segmentation step by adopting a convex interpolation algorithm to obtain the description of the geometric shape of the left ventricle and obtain the papillary muscle at the boundary of the endocardium.

Embodiments of the present invention provide a system for automatically deriving parameters of a human heart from ultrasound results. The first neural network is arranged to receive a plurality of echocardiography images and to classify the images as one of at least a two-lumen tangent plane and a four-lumen tangent plane. The second neural network is arranged to receive echocardiography images comprising two or four-lumen tangent planes and to identify endocardial boundaries of a left ventricle (LV) for each tangent plane. End systolic and end diastolic images are then identified and parameters such as LV volume, ejection fraction, overall longitudinal strain, and regional longitudinal strain are calculated.

The invention belongs to the field of combination of medical image processing and deep learning, and discloses a PGMS-Net model construction method for heart MRI image segmentation, which comprises the following steps: generating a medical image data set of heart MRI; the medical image data set comprises a heart MRI image and a corresponding endocardium mask image, an epicardium mask image and a right ventricle mask image; a network model is defined to take a MogaNet encoder-decoder structure as a main network structure, and preliminary feature extraction is carried out on the heart MRI image; adding a myocardial differential attention module into the main network structure to focus the model on a myocardial structure region; a layered supervision attention module is added to realize accurate supervision and optimization of the right ventricular boundary and the internal structure; and training the network model by using the medical image data set, and constructing a PGMS-Net model for heart MRI image segmentation. According to the technical scheme, the lightweight characteristic of the model can be kept while the heart structure segmentation precision is remarkably improved, and a path is provided for clinical popularization of heart MRI analysis.

A system for sensing multiple local electric voltages from endocardial surface of a heart, includes: an elongate tubular member having a lumen, a proximal end and a distal end; a plurality of flexible splines; an anchor for securably affixing the proximal portions of the splines, where the anchor is securably affixed within the lumen of the elongate tubular member at the distal end of the elongate tubular member; and a metallic tip for securably affixing the distal portions of the splines.

The invention discloses an ablation needle suitable for treating hypertrophic cardiomyopathy, an ablation needle assembly and an ablation system.The ablation needle comprises an electrode needle body, and the far end of the electrode needle body is provided with a first main inclined face; the distance between the near end of the first main slope and the axis of the electrode needle body is larger than or equal to the distance between the far end of the first main slope and the axis of the electrode needle body, and the included angle between the first main slope and the axis of the electrode needle body ranges from 15 degrees to 60 degrees. The far end portion of the electrode needle body is further provided with a second main inclined face, the second main inclined face and the first main inclined face are oppositely arranged, and the included angle between the second main inclined face and the axis of the electrode needle body ranges from 5 degrees to 30 degrees. The ablation area at the far end of the electrode needle body is no longer spherical or nearly spherical, so that the maximum width of the ablation area is reduced, the electrode needle can adapt to a flat heart ventricular septum structure, ablation is prevented from penetrating into the endocardium, a conduction bundle is prevented from being damaged, and the electrode needle is particularly suitable for radiofrequency ablation treatment of hypertrophic cardiomyopathy.