88 results about "Endocardium" patented technology

The invention provides a four-dimensional cardiac function imaging method and device based on a biological magnetic signal. The method comprises the following steps: acquiring a magnetocardiogram signal of a to-be-detected object and dynamic structure information of a target trunk part in a full cardiac cycle; wherein the target trunk part at least comprises double lungs, a trunk, a heart cavity of the trunk and a pericardium structure, and the dynamic structure information comprises a contour structure and a multi-frame dynamic image; performing spatial registration on the dynamic structure information and the sensor for acquiring the magnetocardiogram signal to obtain coordinates of the sensor in a coordinate system of the dynamic structure information; according to the dynamic structure information, the coordinate of the sensor and the magnetocardiogram signal, calculating and reconstructing cardiac electrical excitation activity to obtain a calculation and reconstruction result; and converting the calculation reconstruction result into a four-dimensional visual image. According to the method, heart magnetic imaging and heart movement are combined, on the basis of obtained dynamic structure information and heart magnetic signals, the characteristics of biological magnetic signals are fully utilized, and the signal processing technology is integrated through space registration, so that accurate reconstruction of four-dimensional representation of the heart and visual display of functional activities are realized; therefore, the obtained four-dimensional visual image can completely represent the dynamic electrophysiological activities of the whole heart (including epicardium, endocardium and intrawall tissues) in a cardiac cycle, and a technical scheme with different concepts is provided for non-invasive imaging of cardiac electrical excitation activities.

A delivery catheter for delivering a pacemaker lead into cardiac tissue. The catheter includes a distal end with a tip having an electrode configured for unipolar ablation of cardiac tissue that provides a breach of the endocardium while minimizing trauma to the patient.

The invention discloses a recombinant adeno-associated virus vector for targeted delivery of VEGF-C (vascular endothelial growth factor-C) and application of the recombinant adeno-associated virus vector in promoting endocardial differentiation to treat coronary heart disease. The rAAV vector comprises transgene for coding VEGF-C protein or VEGF-C protein functional variant and a tissue-specific promoter operably connected to the transgene, wherein the tissue specific promoter is capable of driving the transgene to be specifically expressed in the heart endothelial cells. According to the treatment method developed by the invention, specific expression of the Vegfc gene in the heart is driven by using an ICAM2 promoter with targeting to endothelial cells, and a remarkable curative effect is shown in a myocardial infarction model mouse. The therapeutic scheme provides a new effective strategy for intervention and treatment of myocardial infarction and chronic heart failure, and has the advantages of high safety, long gene expression duration, extremely low immune response to a host and the like.

A biorobotic hybrid heart that preserves organic intracardiac structures and mimics cardiac motion by image-guided replication of the cardiac myofiber architecture of the left ventricle with an active synthetic myocardium that drives the motion of the heart. The active soft tissue mimic is adhered to the organic endocardial tissue in a helical fashion using a custom-designed adhesive to form a flexible, conformable, and watertight organosynthetic interface.

The utility model relates to the technical field of medical instruments, in particular to a pacemaker electrode wire, which comprises a wire conduit, the wire conduit comprises a head part and a tail part which are connected with each other, the head part is provided with an electrode assembly, and the electrode assembly comprises a first electrode and a second electrode which are electrically connected with each other. The first electrode and the second electrode are arranged in a spaced mode in the direction from the head to the tail, and a fixing piece located between the first electrode and the second electrode is arranged on the outer side of the wire conduit. The head of the wire conduit can be sent to the right ventricular apex of the heart of a patient through vein puncture, and the fixing piece is in contact with and fixed to the surface of the endocardium, so that the first electrode is firmly fixed to the right ventricular apex, the electrode wire is kept stable in the heart of the patient, and the electrode wire is prevented from shifting or falling off; and the normal cardiac function of the patient is ensured.

A force sensor assembly for use in the field of cardiac ablation, for the ablation-based treatment of atrial fibrillation and other cardiac arrhythmias. Various embodiments of the disclosure are directed to a catheter distal force sensor for measuring catheter tip-to-endocardial wall force by measuring displacement of irradiation patterns sensed with a two-dimensional imaging sensor. The disclosed devices sense an array of irradiation pattern characteristics, including changes in size and location of irradiation shapes of the irradiation pattern. In some embodiments, multiple irradiation spots are tracked with the two-dimensional imaging sensor to infer the components of a reaction force vector acting the force sensor assembly. The disclosed force is designed to accommodate typical catheter tip dimensions, the outer diameter of these usually being less than or equal to 3 mm.

Systems, devices, and methods for delivering pulsed electric field ablation energy to endocardial tissue are disclosed, wherein the system includes a pulsed waveform signal generator for medical ablation therapy and an endocardial ablation device including at least one electrode for delivering ablation pulses to tissue. The signal generator can deliver voltage pulses to the ablation device in the form of a pulsed waveform. The system can include a cardiac stimulator for generating a pacing signal and for delivering a pulsed waveform in sequence in synchronization with the pacing signal.

The utility model provides a novel cardiac pacemaker lead fixing device belongs to medical appliance technical field, this novel cardiac pacemaker lead fixing device, include: lead body, the inside of lead body is equipped with thin metal wire, and the surface is provided with rotating handle. The utility model: the lead body is passed through the protection sheath pipe, and the anchor head end structure of lead body one end is moved to the inside of heart, until the main helical silk of nickel titanium alloy is made on the anchor head end and is fixed with the outer layer of myocardium, further adjusts the rotating handle on the surface of lead body to make the electrode end continue to move, the diameter between a plurality of inner layer's auxiliary micro helical silk changes in the process of rotating to drive a plurality of anchor block rotation and move and pass through endocardium, cooperate a plurality of anchor block surface's anchor hook and enhance the stability of lead body fixed, realize the purpose of anchor head end grading anchor operation.

The invention discloses a biomarker combination for predicting PCI postoperative LVR of an STEMI patient and application of the biomarker combination, and belongs to the technical field of biology. The research discovers that in a left ventricular remodeling (LVR) group and a non-left ventricular remodeling group after percutaneous coronary intervention (PCI) of a patient suffering from acute ST segment elevation type myocardial infarction (STEMI), a left ventricular endocardial lower myocardial overall longitudinal strain (GLS internal) value, a lung B-line integral, a serum sFRP5 level and Apelin-13 show significant differences. Through combined prediction analysis, it is found that the GLS internal value, the lung B-line integral, the serum sFRP5 and the Apelin-13 have excellent prediction performance on whether the LVR occurs after the PCI operation of the STEMI patient or not, high-risk groups, suffering from the LVR after the PCI operation, of the STEMI patient can be accurately and efficiently recognized, intervention is conducted as soon as possible, and the life quality of the patient is expected to be improved.

Disclosed are various configurations of electrodes with accompanying extensions and wires configured to be attached at or near the left atrium of a heart to allow the device to be held snug against the endocardium and out of the blood flow for low energy defibrillation of the atria in response to atrial fibrillation or other atrial arrhythmias. The portion of the lead internal to the atrium (e.g., the left atrium) is restrained against the endocardium of the left atrium by way of a restraint mechanism. In one example, the electrode is configured to attach to the atrial septum, with wires containing memory-shaped metal to keep the wires against the heart wall. In yet another example, the electrode is configured to be part of a mitral valve device.

The present invention discloses a biopsy forceps guiding catheter that can be used for zero-ray myocardial biopsy, comprising a catheter body, wherein a central cavity penetrating through both axial ends of the catheter body is provided inside the catheter body, at least one electrode element is provided at the first axial end of the catheter body, an airbag component is provided at the first axial end of the catheter body near the rear side of the electrode element, the electrode element is connected to an electrical connection assembly extending to the second axial end of the catheter body, the electrical connection assembly is connected to an electrocardiogram monitor, and the airbag component is connected to a ventilation assembly extending to the second axial end of the catheter body. The electrocardiogram and injury current in the cardiac cavity are recorded by the electrocardiogram monitor leads to select a site with a significant injury current for sampling, thereby reducing the influence of scars and fat tissue on the quality of the sampled sample, and the airbag component can drift and move with the blood, thereby solving the problem that the current biopsy forceps need to rely on X-ray guidance to be delivered into the ventricle and it is difficult to accurately obtain a specific layer of myocardium under the endocardium during sampling.

This invention discloses a method for preparing a simulated heart model and the simulated heart model itself. The method for preparing the simulated heart model includes: dividing a digital heart model into two parts along its coronal plane; preparing corresponding molding molds according to the structural characteristics of the two parts, each molding mold including an outer molding mold and an inner cavity molding mold; applying silicone to the molding surfaces of the outer molding mold and the inner cavity molding mold to form the endocardium and epicardium; applying silicone to the portion of the inner cavity molding mold used for molding the valve to form the valve; assembling the outer molding mold and the inner cavity molding mold to form a cavity; sequentially injecting silicone of corresponding hardness into the regions of the cavity used for molding the atrial myocardium, interatrial septal myocardium, ventricular myocardium, and interventricular septal myocardium to form heart model halves; and bonding the heart model halves corresponding to the two molding molds together to obtain the simulated heart model.

A system for sensing multiple local electric voltages from endocardial surface of a heart, includes: an elongate tubular member having a lumen, a proximal end and a distal end; a plurality of flexible splines; an anchor for securably affixing the proximal portions of the splines, where the anchor is securably affixed within the lumen of the elongate tubular member at the distal end of the elongate tubular member; and a metallic tip for securably affixing the distal portions of the splines.

The application provides a multipurpose electrode for positioning, guiding and puncturing, comprising a mapping electrode head, a bending sheath, a magnetic positioning sensor, a mapping tube electrode, a mapping tube, a handle and a guide wire; wherein the mapping tube is a multi-cavity tube, comprising a signal line cavity, a magnetic sensor cable cavity and a bending sheath cavity for the bending sheath; the guide wire is arranged in the bending sheath, the mapping electrode head is arranged at one end of the mapping tube, the handle is connected to the other end of the mapping tube, two mapping tube electrodes are arranged on the mapping tube, and the magnetic positioning sensor is arranged between the two mapping tube electrodes; the application integrates many functions such as electromagnetic positioning, endocardial potential mapping, electrical excitation sequence mapping, excitation time slot mapping, accurate positioning of the catheter head end region, point radio frequency ablation and guide wire delivery. One catheter can be used in many different surgical procedures and scenes.

The invention relates to the technical field of cardiac electrophysiology catheters, and aims to provide a pulsed electric field ablation microcatheter which comprises a catheter part and an operation part, the catheter part comprises an anti-injury section, a tail end catheter body, a catheter body transition section and a near-end catheter body, and the top end of the tail end catheter body is welded to the front end of the anti-injury section; the top end of the catheter body transition section is welded to the front end of the tail-end catheter body, the top end of the near-end catheter body is welded to the front end of the catheter body transition section, an electrode is arranged on the tail-end catheter body, a guide wire is inserted into the catheter part, the catheter part comprises an inner layer and an outer layer, and a braid layer is arranged between the inner layer and the outer layer. The microcatheter can be guided by a guide wire to reach a target area along a cardiac blood vessel, and a pulsed electric field is emitted to surrounding target myocardium through a tail end electrode for ablation; the target area is subjected to combined ablation by combining with the endocardium catheter, and finally the requirement for target myocardial transmural injury is met.

A needle-injection catheter includes a catheter body having a distal end, a proximal end, a stiff proximal portion, a flexible distal portion, and a delivery lumen extending therethrough. In a first embodiment, a straight injection needle extends coaxially from a distal tip of the flexible portion of the catheter body, and a plurality of penetration limiting elements positioned circumferentially about a base of the straight injection needle and configured to fold radially inwardly against a shaft of the needle when constrained in a tubular lumen and to extend radially outwardly when unconstrained. In a second embodiment, a helical needle extends from the distal tip of the flexible portion of the catheter body. The helical needle has at least one helical delivery lumen connected to receive an injectable substance from the delivery lumen of the catheter body.

VfA cardiac therapy uses an implantable medical device or system. The implantable medical device includes a tissue piercing electrode that is implanted from the Koch triangle area of the right atrium through the right atrial endocardium and the central fibrous body into the basal region and / or septal region of the left ventricular myocardium of the patient's heart. The device may include a right atrial electrode, a right atrial motion detector, or both. The device may be fully implanted within the patient's heart or one or more leads may be used to implant the electrodes into the patient's heart. The device may be used to provide cardiac therapy, including single chamber or multi-chamber pacing, atrioventricular synchronous pacing, asynchronous pacing, triggered pacing, cardiac resynchronization pacing, or tachycardia-related therapy. Separate medical devices may be used to provide some of the functions for cardiac therapy, such as sensing, pacing, or shock therapy.

A method of calculating an atrial wall thickness through a device including a processor and a memory according to an embodiment of the present disclosure may include (a) receiving image data for a patient's atrium as input data, (b) calculating endocardial and epicardial borders corresponding to starting and ending points of the atrial wall thickness from the received input data, and (c) calculating the patient's atrial wall thickness using the calculated endocardial and epicardial borders, wherein the image data for the patient's atrium received in the step (a) is a plurality of mask label image data for respective tomographic images of the patient's atrium acquired from computed tomography (CT) scans for the patient's atrium, and the mask label image data is data in which one or more pixels corresponding to an atrial wall region including the patient's atrium and an inner region of the atrium, other regions within the patient's heart disposed around the patient's atrium, and regions other than the patient's heart, respectively, are assigned with labels having different numerals for the respective regions.

A catheter utilizes a distal electrode array configured for quantification of endocardial or epicardial propagation velocity, with electrodes defining approximately equilateral triangles, such that the calculated velocity can be approximated regardless of the wave front direction. The distal electrode array can also include resilient splines carrying the electrodes such that the splines can deform to ensure contact between the electrodes and the heart tissue. Additionally, the electrodes of the distal electrode array can be individually addressable. Bipolar ablation lines or boxes can also be implemented using two parallel catheters at the endocardium and at the epicardium. Certain configurations include one or more distal electrode arrays of sufficient size to span an entire ventricular tachycardia (VT) circuit. The catheter may also be configured to detect block lines by pacing from edge pacing electrodes of the distal electrode array, and / or to detect fiber orientation by pacing from several edge pacing electrodes.

The application relates to a magnetic navigation guiding tearable sheath for heart conduction bundle pacing, which comprises a sheath body and a joint fixedly connected to the rear end of the sheath body, the sheath body comprises a front soft section and a rear fixed section, and the front soft section can be arbitrarily bent; a plurality of pairs of half-ring magnets are arranged on the outer surface of the front soft section close to the head end, two half-ring magnets in each pair of half-ring magnets are symmetrically arranged and form a ring, and a gap is left between the two half-ring magnets; three electrodes are arranged on the head end of the front soft section and are uniformly distributed in the circumferential direction, the three electrodes can be combined in any two, and three electrode pairs for intracardiac potential recording and positioning are formed; each electrode is connected with an electrode lead wire, and the rear end of the sheath body is provided with an electrode tail wire interface, and the other ends of the three electrode lead wires are fixedly arranged in the electrode tail wire interface. The application is beneficial to intracardiac potential recording and positioning, is convenient to contact with the heart cavity, stably adheres to the endocardium, and ensures that the pacing electrode is stably rotated out.

System for endocardial injection are disclosed. An example system may include a first steerable catheter having a first lumen formed therein. A second steerable catheter may be disposed within the first lumen. The second steerable catheter may have a second lumen formed therein. An injection catheter may be disposed within the second lumen. The injection catheter may have a distal end region. The distal end region may include an imaging section and a needle section. The system may include an imaging device configured to be disposed within the imaging section.

A system for sensing multiple local electric voltages from endocardial surface of a heart, includes: an elongate tubular member having a lumen, a proximal end and a distal end; a plurality of flexible splines; an anchor for securably affixing the proximal portions of the splines, where the anchor is securably affixed within the lumen of the elongate tubular member at the distal end of the elongate tubular member; and a metallic tip for securably affixing the distal portions of the splines.

The present disclosure provides a method for determining a cardiac hemodynamic parameter and an electronic device. The accuracy of the cardiac hemodynamic parameter is improved. The method comprises: extracting a cardiac tissue signal and a contrast microbubble signal in a current frame of cardiac ultrasound image to obtain a cardiac tissue image and a contrast microbubble image, and identifying an endocardial region in the cardiac tissue image; obtaining the identification position of each target contrast microbubble in the current frame of cardiac ultrasound image based on the pixel value of each pixel point in the endocardial region and the pixel value of the neighborhood pixel points of each pixel point in the contrast microbubble image; obtaining the target position of the target contrast microbubble in the current frame of cardiac ultrasound image through the identification position of the target contrast microbubble for any target contrast microbubble; obtaining the instantaneous velocity of the target contrast microbubble based on the target position of the target contrast microbubble in the current frame of cardiac ultrasound image and the target position of the target contrast microbubble in the last frame of cardiac ultrasound image; and obtaining the viscosity blood flow friction by using the instantaneous velocity of each target contrast microbubble.

The invention discloses a composite electrophysiological positioning and contact force measuring method and system. The method comprises the following steps: constructing a three-dimensional space non-uniform electric field; through an optical trap structure integrated at the tip of the catheter, preset charged particles are captured, and the intensity of a vector electric field is sensed; acquiring a displacement signal of the particle, and decoupling the displacement signal into a three-axis electric field component; converting the electric field component into a three-dimensional space position of the tip of the catheter; three-dimensional contact force generated by contact between the catheter and the endocardium is detected through an optical fiber sensing structure arranged at the tip end of the catheter, and measurement is carried out through optical parameter changes of the optical fiber sensing structure. The system comprises a three-dimensional non-uniform electric field construction module; the composite conduit includes: a vector electric field measurement unit; the three-dimensional contact force measuring unit comprises at least one FBG (Fiber Bragg Grating) or F-P (Fabry-Perot) cavity arranged on the optical fiber; and a signal processing module. The principle is innovative, and a three-dimensional electrophysiological positioning composite three-dimensional contact force measurement scheme with micron-level positioning precision, low cost and open compatibility is provided.

Brugada syndrome and related forms of ion channelopathies, including ventricular asynchrony of contraction, originate in the region near the His bundle or para-Hisian regions of the heart. Manifestations of Brugada syndrome can be corrected by delivering endocardial electrical stimulation coincident to the activation wave front propagated from the atrioventricular (AV) node early enough to compensate for the conduction problems that start in those regions. The stimulation can be delivered in multiple modes and can include waveforms of the same polarity delivered to a site within the region near the His bundle or para-Hisian regions of the heart associated with a low cardiac electrical asynchrony level or can include at least two single-phased superimposed waveforms of opposite polarity delivered through a pair of pacing electrodes relative to a reference electrode, which can be delivered to any site within the region near the His bundle or para-Hisian regions.

System for cooled endocardial injection are disclosed. An example system may include a steerable catheter having a first lumen therein. The system may include a cooling circuit disposed along at least a portion of the steerable catheter, the cooling circuit having a fluid inlet, a fluid outlet, a proximal end, and a distal end. The cooling circuit may include a first lumen section extending distally along the steerable catheter and including the fluid inlet and a second lumen section extending proximally along the steerable catheter and including the fluid outlet. The system may include an injection catheter disposed in the first lumen. The injection catheter may be configured to deliver a cooled therapeutic fluid to endocardial tissue.

Cardiac mapping catheters and methods for using the catheters are described. The catheter can detect the presence, direction and / or source of a depolarization wave front associated with cardiac arrhythmia. A mapping catheter includes a plurality of bipolar electrode pairs in which the members of each pair are opposed to one another across a perimeter, for instance in a circular pattern (compass mode). The spaced arrangement of the electrodes can be utilized to identify directional paths of moving electric fields or wave fronts in any direction passing across the endocardial surface. Double potential (DP) recordings in compass mode can provide a regional assessment for the existence of rotational activity. Simultaneous DP recordings in compass mode, narrow-adjacent bipolar, and unipolar recording provide an accurate assessment of the time, location, and path that a rotational mechanism breaches a perimeter of electrodes. Accurate time, location, and path of perimeter breaches can be used to electrically track rotational mechanisms during atrial fibrillation.

The present invention provides an image processing device for evaluating cardiac images and a method for identifying ventricular states. In this method, regions of interest are identified from multiple target images, grayscale value changes of multiple pixels in the regions of interest in those target images are determined, and one or more representative images are obtained based on the grayscale value changes. The target images are pixels within the endocardial contour of the left ventricle, with the boundaries of the region of interest roughly located on both sides of the bottom of the endocardial contour, and the region of interest corresponds to the mitral valve. Grayscale value changes are related to the movement of the mitral valve. The representative images are used to evaluate the state of the left ventricle. In this way, the end-systole and end-diastole of the heart can be quickly and accurately identified.

System for endocardial injection are disclosed. An example system may include a first steerable catheter having a first lumen formed therein. A second steerable catheter may be disposed within the first lumen. The second steerable catheter may have a second lumen formed therein. An injection catheter may be disposed within the second lumen. The injection catheter may have a distal end region. The distal end region may include an imaging section and a needle section. The system may include an imaging device configured to be disposed within the imaging section.

An ultrasound imaging system computes real time physiological parameters from measurements of anatomical features in ultrasound image data using a neural network to identify the location of the anatomical features. In one embodiment, cardiac parameters are computed from endocardial wall tracings in M-mode ultrasound image data that are identified by the neural network.