44 results about "Ischemic region" patented technology

A method and apparatus for improving blood flow to an ischemic region (e.g., myocardial ischemia) a patient is provided. An ultrasonic transducer is positioned proximate to the ischemic region. Ultrasonic energy is applied at a frequency at or above 1 MHz to create one or more thermal lesions in the ischemic region of the myocardium. The thermal lesions can have a gradient of sizes. The ultrasound transducer can have a curved shape so that ultrasound energy emitted by the transducer converges to a site within the myocardium, to create a thermal lesion without injuring the epicardium or endocardium.

The invention provides a method for augmenting circulation in a patient having carotid stenosis. An elongate tubular member is provided having a lumen communicating with a port at a distal end. The tubular member is inserted into a peripheral artery and the distal port is advanced into a first carotid artery substantially free of a lesion where the patient possesses a second carotid artery substantially occluded by a lesion. Blood is perfused into the first carotid artery through the tubular member. Contralateral flow is augmented to improve perfusion to an ischemic region distal to the carotid stenosis. Angioplasty and stenting can be used to open the lesion in the second carotid artery.

Apparatus for treatment of an ischemic region of brain cells in a cranium, comprising a skull covering adapted to cover at least part of the cranium, at least one guide attached to the skull covering, and a laser source which is operative to direct a laser beam through the at least one guide into the cranium. The at least one guide may include an optic filiter or a waveguide.

A method and apparatus for improving blood flow to an ischemic region (e.g., myocardial ischemia) a patient is provided. An ultrasonic transducer is positioned proximate to the ischemic region. Ultrasonic energy is applied at a frequency at or above 1 MHz to create one or more thermal lesions in the ischemic region of the myocardium. The thermal lesions can have a gradient of sizes. The ultrasound transducer can have a curved shape so that ultrasound energy emitted by the transducer converges to a site within the myocardium, to create a thermal lesion without injuring the epicardium or endocardium.

A method for locating an ischemic region in the heart of a subject includes establishing three dimensional coordinates axes with respect to the torso of the subject as a reference; establishing as a reference a multi-dimensional representation of the heart defining at least three dimensional coordinate axes of the heart, the multi-dimensional representation defining at least the base of the heart and a middle section of the heart to thereby prescribe a surface of the heart on the reference multi-dimensional representation of the heart; and orienting the three dimensional coordinate axes of the heart from an initial position offset with respect to the three dimensional coordinates with respect to the torso of the subject to an imaginary position wherein at least one axis of the heart is parallel to or coincident with at least one of the three dimensional coordinate axes with respect to the torso of the subject. Corresponding displays are disclosed also.

Disclosed is an apparatus and method for preventing secondary ischemic injury in the brain. The apparatus includes an interstitial brain probe and an introducer sheath, which are placed into an ischemic region of the brain by stereotaxic surgical technique. The interstitial brain probe and introducer sheath provide for thermal coagulation to provide hemostasis, aspiration of blood clots, infusion of therapeutic agents, and localized hypothermia within an ischemic region of the brain. The interstitial brain probe cools an ischemic region of the brain from within the ischemic region, and cooling is substantially limited to the ischemic region. Cooling is provided for a period of time greater than one hour.

The invention provides a method and device for segmenting cerebral ischemia areas in diffusion-weighted images. The method comprises the following steps of: dividing diffusion-weighted images of a plurality of super-acute ischemic stroke patients into test images and training images; training a random forest model, a learning dictionary and a support vector machine model according to the trainingimages; carrying out initial cerebral ischemia area segmentation by utilizing the trained random forest model according to grey features of voxels in the test images; determining a sparse encoding matrix of a local image block feature vector of each voxel in connected regions on the basis of the trained learning dictionary; and classifying each connected area by utilizing the trained linear support vector machine model according to a package feature of each connected area, and deleting the connected areas, in which non-ischemic tissues are located, from a first initially segmented image so asto obtain an optimal segmented image. According to the method and device, automatic recognition and segmentation of super-acute cerebral ischemia areas can be solved, and the ischemia area segmentation precision is improved.

The invention belongs to the technical field of medical early warning, and discloses an early warning system and method for cerebral apoplexy. The early warning system for cerebral apoplexy comprisesan image collection module, a physiological index collection module, a main control module, an image processing module, a risk evaluation module, a warning module, a data storage module and a displaymodule. According to the system and method, through the image processing module, automatic identification and segmentation of a cerebral ischemia zone in a super-acute stage can be achieved, and the segmentation precision of the ischemia zone is improved; data preprocessing, feature selection and feature optimization are conducted through the risk evaluation module, and obtained data features aremore effective; an XGBoost method is adopted for automatically generating the risk probability that a target group of people suffer from cerebral apoplexy, community health screening can be more efficiently and conveniently conducted, and a doctor can be helped to more simply and quickly evaluate the risk that the target group of people suffer from cerebral apoplexy; health screening can be strongly pushed, so that potential users with cerebral apoplexy are more quickly found, and earlier warning is given, so that earlier and more effective treatment is conducted.

The invention provides an acute cerebral ischemia image segmentation model training method and an acute cerebral ischemia image segmentation method. The method comprises steps that magnetic resonance image data is acquired, and brain tissue images are extracted; normalization operation of the extracted brain tissue images is carried out; ischemic areas of the extracted brain tissue images are acquired as a positive sample, and expansion of the positive sample is carried out according to a set expansion coefficient to acquire data which is taken as a negative sample; characteristic vectors are respectively extracted from magnetic resonance images T2, DWI and ADC, the positive sample and the negative sample of asymmetric maps ASM, and normalization processing on the characteristic vectors is carried out; based on the characteristic vectors after normalization processing, an acute cerebral ischemia segmentation model is acquired through an SVM classifier. The method is advantaged in that the provided acute cerebral ischemia segmentation model can be applied to ischemic area segmentation, a segmentation speed is fast, and high accuracy is realized.

The invention provides an analyzing and processing method for analyzing and processing the magnetic resonance image of the acute ischemic stroke the method specifically comprises the steps of according to the data of a magnetic resonance image, acquiring the data of the magnetic resonance image, conducting the gold standard treatment on the data of the magnetic resonance image, setting the data of the image after the gold standard treatment as a positive sample set, obtaining a negative sample based on the data of the image after the gold standard treatment, obtaining a negative sample based on the data of the image in an initial ischemic region, obtaining a negative sample set, extracting the feature vectors of the positive sample set and the negative sample set, combining the extracted feature vectors as a training dictionary, obtaining to-be-segmented voxels based on the data of the image in an initial ischemic candidate region, and judging whether to-be-segmented voxels are ischemic voxels or not according to the training dictionary. According to the technical scheme of the invention, based on the analyzing and processing method for analyzing and processing the magnetic resonance image of the acute ischemic stroke, an ischemic region can be segmented more accurately. Meanwhile, the segmentation accuracy is high and the influence of noises or artifacts is small.

Disclosed is an apparatus and method for preventing secondary ischemic injury in the brain. The apparatus includes an interstitial brain-cooling probe that is placed into an ischemic region of the brain by stereotaxic surgical technique, and a control console. The control console provides a source of cooling fluid to the interstitial brain-cooling probe, and controls the flow of cooling fluid according to signals received from a temperature sensor mounted on the interstitial brain-cooling probe. The interstitial brain-cooling probe cools an ischemic region of the brain from within the ischemic region, and cooling is substantially limited to the ischemic region. Cooling is provided for a period of time greater than one hour.

The invention discloses an application of oxymatrine in medicines for treating neonatal hypoxic ischemic brain damages. An experiment result shows that oxymatrine has a certain dose-effect correlation when used in a safe dose range; when the dose is 120mg / kg of body weight, the volume of ischemia area cerebral infarction and neuron apoptosis rate can be reduced; pathological damages to brain tissues can be relieved; the activity of antioxidase in the brain tissues can be improved; and the content of malondialdehyde is lowered. The oxymatrine has the effects of preventing injuries and deaths caused by neonatal hypoxic ischemic brain damages and promoting neural functional recovery.

A brain imaging system includes a first imaging device, a second imaging device, a third imaging device and a central processor. The first imaging device captures a first brain image, and calculates a cerebral blood flow, a cerebral blood volume, a cerebral blood mean transit time and a first contrast agent time to peak. The second imaging device captures a second brain image, and calculates the cerebral blood flow, the cerebral blood volume, the cerebral blood mean transit time and a second contrast agent time to peak. The central processor generates an image of a vessel occlusion, infarction or ischemia region respectively according to the vessel occlusion, infarction or ischemia regions in the first brain image and in the second brain image. The third imaging device obtains a brain atrophy region according to the cerebral cortex volume calculated by the third imaging device.

The invention relates to a pharmaceutical formula with functions of tonifying kidney and reducing phlegm as well as promoting blood circulation and inducing resuscitation. The pharmaceutical formula comprises the following raw materials in parts by weight: 10-20 parts of radix rehmanniae preparata, 10-21 parts of rhizoma polygonati, 8-16 parts of fructus corni, 2-8 parts of radix notoginseng, 8-14parts of rhizoma chuanxiong, 10-20 parts of radix salviae miltiorrhizae, 10-20 parts of rhizoma gastrodiae, 9-20 parts of poria cocos, 8-16 parts of rhizoma acori graminei, 8-17 parts of rhizoma pinelliae, 10-20 parts of lucid ganoderma, 20-30 parts of radix astragali seu hedysari, 15-30 parts of herba cistanche and 0.1-0.2 part of borneol. Due to the compatibility of medicines, the pharmaceutical formula has the function of nourishing kidney and strengthening essence, tranquilizing mind and promoting intelligence, reducing phlegm and inducing resuscitation, activating blood to dredge vesselsas well as removing blood stasis and promoting fresh blood production. The pharmacological action of the pharmaceutical formula is consistent with modern medical treatment principle of vascular dementia, and comprises increment of blood flow in the ischemic regions, improvement of brain metabolism and free radical metabolism, and the like; therefore, the pharmaceutical formula provides a theoretical basis for the treatment of the vascular dementia.

The invention relates to an ischemic penumbra recognition method and equipment, an electronic device and a storage medium. The method comprises the steps: obtaining an ischemic region parameter map and an infarction region parameter map of the brain of a patient based on a perfusion image, performing false positive removal on the ischemic region parameter map and the infarction region parameter map to obtain an ischemic region mask and an infarction region mask, and determining the ischemic penumbra of the brain of the patient according to the ischemic region mask and the infarction region mask. Through application of the method and the equipment, the problem of relatively low accuracy of the ischemic penumbra obtained based on threshold segmentation in related technologies is solved, and the accuracy of identifying the ischemic penumbra is improved.

The invention relates to the field of biological pharmacy, and discloses a preparation method and application of a cyclosporine A-loaded efficient brain-targeted drug delivery system. The drug delivery system is composed of CsA and Fn; by utilizing the characteristic that ferritin is denatured in acetone and can be renatured in water, the CsA is wrapped in a cage structure (CsA(at)Fn) of the Fn through a solvent evaporation method; the CsA(at)Fn can be mediated by transferrin receptors on the surfaces of brain capillary endothelial cells to penetrate through a blood brain barrier and be accumulated in an ischemic area; on one hand, the CsA(at)Fn van protect the integrity of the blood brain barrier and reduce accumulation of inflammatory factors in a cerebral ischemic area; and on the other hand, the CsA(at)Fn taken by neuronal cells can inhibit the opening of mitochondrial permeability conversion pores of the neuronal cells, reduce the release of mitochondrial ROS and cytochrome C, inhibit the apoptosis of the neuronal cells and play a role in neuroprotection.

The invention discloses TAT-LBD-PEP fusion protein and application of the TAT-LBD-PEP fusion protein in treatment of central nervous system lesion. The TAT-LBD-PEP fusion protein is combined with myelin inhibiting factors MAG, Nogo-66 and OMgp, accordingly the axon regenerative capacity is promoted through antagonism PirB effect, and the TAT-LBD-PEP fusion protein has the advantages of being high transduction efficiency and easily transmitting a blood-spinal barrier and a blood brain barrier, can transduce targeting to a hurt region and has the enrichment effect on an ischemic region. The problems that additional harm of nervous tissues is caused by the protein injection in a micro-injection mode or other injection modes and macromolecule cannot transmit the blood-spinal barrier and the blood brain barrier are solved, and the shortcoming that corresponding biological concentration cannot be met is overcome, and the targeting is transduced to the ischemic region through a ligand binding domain (LBD). The TAT-LBD-PEP fusion protein can be prepared in large-scale mode, is low in cost and high in activity, and is used for treatment of various brain and spinal cord injury including cerebral ischemia hypoxia, cerebral hemorrhage, cerebral trauma, spinal cord injury and the like and promoting regeneration of nervous tissues and neural functional recovery.

The invention discloses a pharmaceutical composition for treating stroke and a preparation method thereof. The pharmaceutical composition for treating stroke is prepared from polygonum oriental flower extract and pharmaceutically available auxiliary materials, wherein the polygonum oriental flower extract is obtained by extracting herb residue (obtained after water extraction is carried out on polygonum oriental flowers) in a dichloromethane-methyl alcohol mixed solution, can be used for activating endogenous neural stem cells, increasing new vessels in an ischemic region, improving blood supply in the ischemic region and promoting neural functional recovery and can be developed into a medicinal preparation for treating ischemic stroke.

The invention discloses an application of verbascoside in preparing medicine for treating hypoxic and ischemic encephalopathy. According to the invention, when in a safe dosage range, verbascoside with a dose of 240 mg / kg can obviously improve early nerve function disorder of a hypoxic and ischemic model of a newborn rat, reduce cerebral infarction volume of an ischemic region and neuron necrosis,experiments show that the verbascoside has the function of promoting recovery of the nerve function and preventing newborn bodies from death or disability caused by hypoxic and ischemic encephalopathy.

The invention discloses application of cytisine (CYT) in medicines for treating cerebral arterial thrombosis. Experiment results indicate that when the cytisine is 1mg / kg which is in a safety dosage range, the autonomic dysfunction of a mouse focal cerebral ischemia model can be remarkably improved, the volume of cerebral infarction in an ischemia area and the apoptosis rate in an ischemic core area and penumbra can be reduced, and a certain dose-pharmacological effect correlation is represented. The experiment results prove that the cytisine has the effects of preventing occurrence of local cerebral arterial thrombosis, reducing death and disability after stroke and promoting neurological function recovery.

The invention provides a medical image processing device and method, a medium and electronic equipment. The medical image processing device comprises: a medical image acquisition module used for acquiring a brain medical image; the voxel value difference acquisition module that is used for acquiring the voxel value difference of the left brain and the right brain in the brain medical image; and the ischemic area acquisition module that is used for acquiring an ischemic area in the brain medical image according to the voxel value difference. According to the medical image processing device, the ischemic area in the brain medical image can be obtained according to the voxel value difference of the left brain and the right brain in the brain medical image, artificial participation is basically not needed in the process, efficiency is high, and errors caused by subjective influence of medical staff are avoided.

The invention provides an ischemic region segmentation method and device, an apparatus and a storage medium. The method comprises the steps of obtaining a cerebral blood flow image of the brain of a target object; calculating a Z score graph corresponding to the cerebral blood flow image based on a predetermined brain image data set of the healthy people; and processing the cerebral blood flow image and the Z score graph by using a pre-trained classification model to obtain an ischemic region segmentation image of the brain of the target object. According to the ischemic region segmentation method, the ischemic region is segmented based on the statistical characteristics of the cerebral blood flow images, the information of individuals and the information compared with healthy groups are comprehensively considered, and the accuracy and robustness of ischemic region segmentation can be improved.

The invention relates to the technical field of image processing, in particular to an ischemic region segmentation method and device, equipment and a storage medium, and the method comprises the steps: obtaining an apparent diffusion coefficient image of the brain of a target object; acquiring a cerebral blood flow image, a cerebral blood volume image and an artery passing time image of the brain of the target object; and processing the apparent diffusion coefficient image, the cerebral blood flow image, the cerebral blood volume image and the artery passing time image by using a pre-trained classification model to obtain an ischemic region segmentation image of the brain of the target object. According to the ischemic region segmentation method, the ischemic region is segmented by combining the diffusion weighted image information and the delayed artery spin marking perfusion image information after marking, mutual information among various images is fully utilized, and the accuracy and robustness of ischemic region segmentation are improved.

The invention relates to the field of stem cells and regenerative medicine, and particularly relates to neural crest cell culture fluid, a preparation method of neural crest mesenchymal stem cells and an application of the neural crest mesenchymal stem cells. Experimental results of the invention show that mesenchymal stem cells of the neural crest stem cell lineage, induced and differentiated by human totipotent stem cells, can obviously improve neurological dysfunctions, reduce an area of an ischemic region, inhibit immune reactions and promote endogenous repairs of brain tissues in a neonatal rat hypoxic-ischemic model, thereby proving that human neural crest-derived mesenchymal stem cells have effects of significantly improving the inflammatory reaction of neonates with ischemic and anoxic encephalopathy and effectively promoting the neural function recovery. The invention also provides a test index for identifying the activity of the neural crest mesenchymal stem cells.

A method for stimulation of collateral development in ischemic cardiac regions comprises the fluid coupling of the left ventricle of the heart to the anterior interventricular vein to stimulate collateral development in ischemic regions. The fluid coupling of the left ventricle of the heart to the anterior interventricular vein includes a control of the diastolic / systolic pressure in the venous system to be within about 20-50 mmHg. The fluid coupling of the left ventricle of the heart to the anterior interventricular vein includes inserting a transmyocardial conduit into the left ventricle and a tri-directional coupler attached to the anterior interventricular vein. An associated apparatus for stimulation of collateral development in ischemic cardiac regions via the fluid coupling of the left ventricle of the heart to the anterior interventricular vein is disclosed.

There is provided a medical image processing apparatus which includes a first extraction unit configured to extract coronary arteries depicted in images of a plurality of time phases relating to the heart, and to extract at least one stenosed part depicted in each coronary artery; a calculation unit configured to calculate a pressure gradient of each of the extracted coronary arteries, based on tissue blood flow volumes of the coronary arteries; a second extraction unit configured to extract an ischemic region depicted in the images; and a specifying unit configured to specify a responsible blood vessel of the ischemic region by referring to a dominance map, in which each of the extracted coronary arteries and a dominance territory are associated, for the extracted ischemic region, and to specify a responsible stenosis, based on the pressure gradient corresponding to a stenosed part in the specified responsible blood vessel.

The invention discloses a mixed cell preparation used for treating myocardial infarction as well as a preparation method thereof and an application thereof. The mixed cell preparation consists of active ingredients and a solvent, wherein the active ingredients are mainly CTs and CSCs. The mixed cell preparation is transplanted for an ischemic region and an ischemic penumbra region of a heart with acute myocardial infarction, so that survival, differentiation and multiplication, on the ischemic penumbra region, of transplanted CSCs or myocardial endogenous CSCs and other derived stem cells can be effectively promoted, and a severely damaged cell network which consists of CTs of a regenerative ischemic myocardium ischemic region is effectively repaired, and therefore, regeneration of infarcted myocardium is facilitated. The mixed cell preparation has curative effect, which is superior to that of independent use of CSCs, BMSCs and CTs, in reducing an infarct size and improving the function of a myocardial infarction heart, and the like after implementing transplantation therapy on acute myocardial infarction. Therefore, the mixed cell preparation can be prepared into a drug for treating myocardial infarction or applied to mechanical apparatuses and instruments.