6 results about "Ischemic region" patented technology

This invention relates to a method for segmenting and analyzing angiographic images of ischemic cerebrovascular diseases. It detects abnormal grayscale transitions, structural breaks, and artifact delay signals in angiographic images, extracts negative prior points indicating suspected ischemic areas, aggregates them to form prior abnormal regions, introduces a symmetric perturbation testing mechanism to determine potential occluded or abnormal vascular segments, and dynamically adjusts the segmentation threshold of the region. A local interference window is established within the determined region, and the frequency and rhythmic features of density stripes are extracted. Through the scaling strategy of the convolution kernel, discontinuous vascular segments caused by non-steady-state pulse changes are compensated for segmentation. Texture difference and frequency domain response offset are calculated. If the offset is within a preset physiological tolerance range, an interpolation completion mechanism is triggered to generate a reliable completion layer for subsequent calibration reference. By analyzing the multipath divergence degree of the vascular branch endpoints and the path offset changes in the image sequence, the previously segmented paths are dynamically adjusted and their continuity is calibrated.

The invention relates to the technical field of medical image processing, in particular to a general surgery department acute abdominal disease operation planning system based on AI image analysis, which comprises an image data acquisition module, a focus feature extraction module, an ischemia analysis module, an operation scheme construction module and a diagnosis result generation module. According to the method, uniform expression of multi-source data in space is guaranteed through numerical fitting and registration of an image sequence, multi-angle extraction of pathological features is achieved by combining quantitative indexes such as intestinal wall thickness, orifice expansion and hydrops density, and systematic marks are formed through deep learning feature fusion. A potential ischemic area can be quickly identified under the condition of complex abdominal lesion, accurate definition of a lesion range is realized by utilizing perfusion indexes and continuous section screening, and a relationship between lesion length and anatomical space is further calculated, so that a quantitative basis is provided for an operation excision range and an anastomosis condition; deviation caused by subjective judgment is reduced, and the pertinence and the executability of a treatment scheme are improved.

This invention provides a biomarker for collateral circulation in CTO patients, MIA3, and its application, belonging to the field of biotechnology. This invention reveals and verifies a significant positive correlation between plasma MIA3 levels and the quality of collateral circulation formation in CTO patients, and its predictive efficacy for good collateral circulation is superior to that of the known key angiogenesis factor VEGFA. This allows MIA3 to serve as a high-value, minimally invasive molecular marker for early, non-invasive identification of a patient's collateral circulation formation potential before interventional surgery, thereby enabling risk stratification and providing an objective basis for individualized treatment decisions (such as whether more aggressive intervention is needed). This invention clarifies that MIA3 is a key link in regulating collateral angiogenesis; by targeting and upregulating MIA3 activity, collateral angiogenesis and maturation in ischemic areas can be precisely promoted, providing a novel non-pharmacological, non-surgical treatment strategy for CTO patients.

The invention relates to a blood flow pressure airtight triple feedback type tubular anastomat system, which relates to the technical field of tubular anastomats, and comprises a near-infrared detection module, which is used for evaluating microcirculation blood flow of a target anastomosis area in real time and identifying an ischemic area in a tissue pre-clipping stage; the intelligent pressure sensing module is used for monitoring the pressure distribution of the contact surface of the nail bin and the tissue in real time in the tissue clipping process and estimating the tissue thickness; the dynamic airtightness detection module is used for performing automatic airtightness detection on the anastomotic stoma after anastomosis is completed and the central rod is withdrawn; and the central data processing module comprises a data acquisition and preprocessing unit, a feature extraction and data matching unit and an intelligent judgment unit. Synchronous acquisition, cleaning, matching and comprehensive analysis of three-dimensional data of blood flow, pressure and airtightness are realized through the central data processing module.

The invention discloses an application of thalidomide in preparation of a medicine for treating ischemic stroke, and a thalidomide drug-loaded nanogel as well as a preparation method and an application of the thalidomide drug-loaded nanogel. The drug-loaded nanogel comprises a polyacrylic acid skeleton, thalidomide loaded on the polyacrylic acid skeleton, and three functional polypeptides, namely transferrin, microglial cell targeting peptide and pH low-insertion peptide, which are coupled with the skeleton. Through the synergistic effect of the three polypeptides, the nanogel can penetrate through a blood brain barrier, accurately targets microglia cells in an ischemic area, and responsively releases thalidomide in an acidic microenvironment. In-vitro experiments show that the nanogel can effectively inhibit expression of inflammatory factors of microglial cells; in-vivo experiments show that the traditional Chinese medicine composition can significantly reduce the cerebral infarction volume, protect the blood-brain barrier, improve the neurological function and cognitive behavior of model animals and increase the survival rate. The invention provides a precise and efficient drug delivery platform for ischemic stroke treatment.