Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of verbascoside in preparing medicine for treating hypoxic and ischemic encephalopathy

A technology of verbascoside and hypoxia-ischemia, which is applied in drug combination, cardiovascular system diseases, pharmaceutical formulations, etc., can solve the problem of protective effect and achieve the effect of reducing cerebral infarction volume and cell necrosis rate

Active Publication Date: 2019-01-04
NINGXIA MEDICAL UNIV
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies by some scholars have proved that the total glycosides of Cistanche deserticola have a protective effect on cerebral ischemia, but the protective effect of verbascoside on hypoxic-ischemic brain injury in newborns is still unclear.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of verbascoside in preparing medicine for treating hypoxic and ischemic encephalopathy
  • Application of verbascoside in preparing medicine for treating hypoxic and ischemic encephalopathy
  • Application of verbascoside in preparing medicine for treating hypoxic and ischemic encephalopathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The use of acteoside in the preparation of drugs for the treatment of neonatal hypoxic-ischemic brain injury, wherein the neonatal hypoxic-ischemic brain injury is the acute stage of ischemic-hypoxic brain injury, and the single application dose of acteoside is 60 mg / Kg, the dosage form of medicine is injection dosage form.

Embodiment 2

[0034] The use of acteoside in the preparation of drugs for the treatment of hypoxic-ischemic brain injury in newborns, wherein the hypoxic-ischemic brain injury in neonates is the ischemic-hypoxic brain injury in the repair period, and the single application dose of actascoside is 120mg / Kg, the dosage form of medicine is powder injection dosage form.

Embodiment 3

[0036] The use of acteoside in the preparation of drugs for the treatment of neonatal hypoxic-ischemic brain injury, wherein the neonatal hypoxic-ischemic brain injury is the repair period of ischemic-hypoxic brain injury, and the single application dose of acteoside is 240mg / Kg, the dosage form of medicine is powder injection dosage form.

[0037] The following animal experiment has further illustrated the effect of above-mentioned embodiment 1 to 3:

[0038] 1. Experimental materials

[0039] 1.1 Animal handling

[0040] 7 days old, newborn SD rats, 12-18g, purchased from the Experimental Animal Center of Ningxia Medical University, animal production license number: SCXK (Ning) 2015-0001. Feeding conditions include standard feed, tap water, room temperature maintained at (24±2)°C, humidity 50-60%, and daily light and dark times of 12 hours each. Before the experiment, the animals were placed in the experimental environment for 3 days to adapt.

[0041] 1.2 Experimental ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an application of verbascoside in preparing medicine for treating hypoxic and ischemic encephalopathy. According to the invention, when in a safe dosage range, verbascoside with a dose of 240 mg / kg can obviously improve early nerve function disorder of a hypoxic and ischemic model of a newborn rat, reduce cerebral infarction volume of an ischemic region and neuron necrosis,experiments show that the verbascoside has the function of promoting recovery of the nerve function and preventing newborn bodies from death or disability caused by hypoxic and ischemic encephalopathy.

Description

technical field [0001] The present invention relates to the application of acteoside, in particular to the application of acteoside in the preparation of medicines for treating neonatal hypoxic-ischemic brain injury. Background technique [0002] Neonatal hypoxic-ischemic encephalopathy (hypoxic-ischemic brain damage, HIBD) is due to various factors such as perinatal asphyxia, amniotic fluid pollution and other factors, resulting in hypoxia and cerebral blood flow reduction or suspension, causing fetal and neonatal brain dysfunction. disease. HIBD is the main cause of neurological diseases in newborns, and it is also the main factor of global child mortality and morbidity. And cognitive dysfunction, severe cases cause neonatal death or neurological sequelae, such as cerebral palsy, epilepsy, mental retardation, memory and audiovisual impairment, seriously affecting the quality of life of newborns, but also a great family and social burden. The pathogenesis of neonatal HIBD...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/7034A61P9/10A61P25/00
CPCA61K31/7034A61P9/10A61P25/00
Inventor 余建强魏炜李玉香刘宁杜娟
Owner NINGXIA MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com