Use of Verbasidin in the preparation of medicaments for the treatment of neonatal hypoxic-ischemic encephalopathy

A technology of verbascoside and hypoxia-ischemia, which is applied in drug combination, cardiovascular system diseases, pharmaceutical formulations, etc., can solve the problem of protective effect and achieve the effect of reducing cerebral infarction volume and cell necrosis rate

Active Publication Date: 2021-04-06
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies by some scholars have proved that the total glycosides of Cistanche deserticola have a protective effect on cerebral ischemia, but the protective effect of verbascoside on hypoxic-ischemic brain injury in newborns is still unclear.

Method used

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  • Use of Verbasidin in the preparation of medicaments for the treatment of neonatal hypoxic-ischemic encephalopathy
  • Use of Verbasidin in the preparation of medicaments for the treatment of neonatal hypoxic-ischemic encephalopathy
  • Use of Verbasidin in the preparation of medicaments for the treatment of neonatal hypoxic-ischemic encephalopathy

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The use of acteoside in the preparation of drugs for the treatment of neonatal hypoxic-ischemic brain injury, wherein the neonatal hypoxic-ischemic brain injury is the acute stage of ischemic-hypoxic brain injury, and the single application dose of acteoside is 60 mg / Kg, the dosage form of medicine is injection dosage form.

Embodiment 2

[0034] The use of acteoside in the preparation of drugs for the treatment of hypoxic-ischemic brain injury in newborns, wherein the hypoxic-ischemic brain injury in neonates is the ischemic-hypoxic brain injury in the repair period, and the single application dose of actascoside is 120mg / Kg, the dosage form of medicine is powder injection dosage form.

Embodiment 3

[0036] The use of acteoside in the preparation of drugs for the treatment of neonatal hypoxic-ischemic brain injury, wherein the neonatal hypoxic-ischemic brain injury is the repair period of ischemic-hypoxic brain injury, and the single application dose of acteoside is 240mg / Kg, the dosage form of medicine is powder injection dosage form.

[0037] The following animal experiment has further illustrated the effect of above-mentioned embodiment 1 to 3:

[0038] 1. Experimental materials

[0039] 1.1 Animal handling

[0040] 7 days old, newborn SD rats, 12-18g, purchased from the Experimental Animal Center of Ningxia Medical University, animal production license number: SCXK (Ning) 2015-0001. Feeding conditions include standard feed, tap water, room temperature maintained at (24±2)°C, humidity 50-60%, and daily light and dark times of 12 hours each. Before the experiment, the animals were placed in the experimental environment for 3 days to adapt.

[0041] 1.2 Experimental ...

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Abstract

The invention discloses the use of verbascoside (Verbascoside) in the preparation of medicines for treating neonatal hypoxic-ischemic brain injury. The experimental results of the present invention show that when used within a safe dose range, verbascoside with a dose of 240 mg / kg can significantly improve the early neurological dysfunction of the hypoxic-ischemic model of neonatal rats, reduce the volume of cerebral infarction and neuronal necrosis in the ischemic region, It is proved that verbascoside can promote the recovery of nerve function and prevent the disability and death of newborns after hypoxic-ischemic encephalopathy.

Description

technical field [0001] The present invention relates to the application of acteoside, in particular to the application of acteoside in the preparation of medicines for treating neonatal hypoxic-ischemic brain injury. Background technique [0002] Neonatal hypoxic-ischemic encephalopathy (hypoxic-ischemic brain damage, HIBD) is due to various factors such as perinatal asphyxia, amniotic fluid pollution and other factors, resulting in hypoxia and cerebral blood flow reduction or suspension, causing fetal and neonatal brain dysfunction. disease. HIBD is the main cause of neurological diseases in newborns, and it is also the main factor of global child mortality and morbidity. And cognitive dysfunction, severe cases cause neonatal death or neurological sequelae, such as cerebral palsy, epilepsy, mental retardation, memory and audiovisual impairment, seriously affecting the quality of life of newborns, but also a great family and social burden. The pathogenesis of neonatal HIBD...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7034A61P9/10A61P25/00
CPCA61K31/7034A61P9/10A61P25/00
Inventor 余建强魏炜李玉香刘宁杜娟
Owner NINGXIA MEDICAL UNIV
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