353 results about "Neurologic function" patented technology

Cells derived from postpartum tissue such as the umbilical cord and placenta, and methods for their use to regenerate, repair, and improve neural tissue, and to improve behavior and neurological function in stroke patients are disclosed.

The present invention relates to a method and apparatus for monitoring haemodynamic function in animals and humans during anaesthesia and surgery. During anaesthesia and surgery the subject's haemodynamic, respiratory, neuromuscular and neurological functions are monitored as indicators of the condition of the health of the subject. Commonly, variations in blood pressure are used to imply corresponding variations in cardiac output, i.e. good blood pressure equals good cardiac output. The present invention utilizes a device to monitor changes of blood flow in peripheral blood vessels of the subject as an indicator of cardiac output. This is believed to provide a much more accurate indicator.

A nutritional supplement composition for normalizing impaired or deteriorating neurological function in humans is composed of: at least one agent which promotes synthesis of ATP and/or creatine phosphate in the body, at least one antioxidant for scavenging free radicals in at least one pathway in the body; at least one agent for normalizing or maintaining membrane function and structure in the body; at least one agent for normalizing or maintaining normal neurotransmitter function in the body; at least one agent for down-regulating cortisol action; and at least one agent for suppressing activation of apoptotic pathways in the body. The composition may further contain one or more of: at least one agent for suppressing inflammation in the body; at least one agent for normalizing or maintaining vascular wall function and structure in the body; at least one agent for normalizing or maintaining function of nerve growth factors and/or neurotropic factors in the body; at least one agent for suppressing toxic metal ionic effects; at least one agent for normalizing or maintaining methyl metabolism in the body; at least one agent for normalizing or maintaining metabolism of insulin and glucose in the body; and at least one agent for up-regulating activity of heat shock proteins in the body. A method for normalizing impaired neurological function in humans modulating nutrient partitioning in a human involves administering the aforementioned composition to the human, preferably on a daily basis, for a therapeutically effective period of time. Preferably, the method further involves having the human follow a stress reduction program, and/or a cognitive retraining program, and/or a dietary program designed to maximize insulin and glucose metabolism.

Therapeutic methods for enhancing neurologic function such as may be desired in individuals having motor and/or cognitive impairment, including that resulting from Alzheimer's disease, dementia, head trauma, mental disease such as depression, stroke and neurodegeneration, as well as in healthy individuals are described, the methods including delivering a cognitive enhancing effective amount of light energy having a wavelength in the visible to near-infrared wavelength range to a target area of the brain. The neurologic function enhancing effective amount of light energy, in accordance with a preferred embodiment, is a predetermined power density (mW/cm²) at the level of the brain tissue being treated, and is delivered by determining a surface power density of the light energy that is sufficient to deliver the predetermined power density of light energy to the target brain tissue. In one embodiment, progenitor cells are treated using light energy and implanted into the central nervous system of a patient.

The invention discloses a heart rate variability analyzing method based on an amplitude spectrum and instruments. The method comprises the following steps that a human body autonomic nervous function monitor is installed, after amplification, filtering and analog-digital conversion are carried out on electrocardio signals collected by an electrocardio electrode slice, an RR interval time sequence is built, the QRS waveform of the electrocardio signals has the features of large amplitude, short time limit, steep waveform and easy recognition, the key for obtaining HRV signals is that the R wave of an electrocardiogram is accurately calibrated, and according to the morphological characteristic of an R wave picture, the wave crest of the R wave is the maximum positive value in a single signal period; the instruments included in the method comprise a preamplifier module used for amplifying the electrocardio signals, a filter module, an A/D conversion module, an R crest positioning module, a signal pseudo crest pseudo differential eliminating module, an RR sequence forming module, an interpolation module and a display module which are sequentially connected, the preamplifier module is connected with the electrocardio electrode slice through a guide line, and the electrode slice is arranged on the surface of the human body skin and used for collecting the electrocardio signals of the human body.

The invention discloses a GRPAK/tetrahydroglyoxaline/RGD ternary conjugate as well as a preparation method and application of the GRPAK/tetrahydroglyoxaline/RGD ternary conjugate. According to the preparation method, L-Lys is served as a link arm, and 1, 3-dioxo-2-[(4-peracetic acid) phenyl]-4, 4, 5, 5-tetramethyl tetrahydroglyoxaline, the GRPAK pentapeptide with a thrombolytic effect, and RGD tetrapeptide with an antithrombosis effect are integrally linked, thus obtaining the GRPAK/tetrahydroglyoxaline/RGD ternary conjugate as shown in formula I. The GRPAK/tetrahydroglyoxaline/RGD ternary conjugate disclosed by the invention has high activity on removing NO free radical, excellent thrombolytic activity and antithrombosis activity; as in-vivo apoplexy activity shown, the GRPAK/tetrahydroglyoxaline/RGD ternary conjugate can effectively protect the neurologic function of a rat subjected to apoplexy, and reduces the brain infarct volume of the rat subjected to apoplexy, and has high apoplexy resisting activity, and can be prepared into a clinical medicine for treating apoplexy or cerebral infarction.

The present invention discloses method and apparatus of detecting, exciting and regenerating sensation, motor and internal organ signals of vertebrate including human, and is especially one kind microelectronic system aided nerve channel function recovering method and apparatus. The nerve channel function recovering apparatus includes two parts, one part for the function reconstruction of the ascending nerve channel and the other part for the function reconstruction of the descending nerve channel. The weak electric signal of the damaged nerve tract or nerve fiber is detected with detecting electrodes, amplified, recognized and extracted to generate controlled electric exciting signal for exciting the damaged nerve tract or nerve fiber to regenerate corresponding nerve signal and restore the function of the damaged nerve tract or nerve fiber micro electronically.

The invention discloses an exercise instrument for preventing deep venous thrombosis of lower limbs. The exercise instrument for preventing deep venous thrombosis of lower limbs comprises a casing, the upper end of the casing is provided with two sliding grooves with corresponding positions, a measuring side wall of the casing is respectively provided with a first device chamber and a sliding plugchamber, the side wall of the casing is fixedly connected to a driving motor, one end of an output shaft of the driving motor located in the first device chamber is fixedly connected to a first bevelgear, the inner wall of the first device chamber is rotatably connected to a driving wheel, the side wall of the driving wheel is coaxially fixedly connected to a second bevel gear meshed with the first bevel gear, the upper end of the casing is provided with a first groove communicated with the first device chamber, and the inner walls of the two sliding grooves are rotatably connected to parallelly-arranged first reciprocating lead screws. The exercise instrument for preventing deep venous thrombosis of lower limbs can massage the foot sole and instep to achieve a function of stimulating limb nerves, an ankle joint is protected from stiffness deformation, the foot drop is effectively prevented, and the rehabilitation of a patient is promoted.

It is intended to provide a drug which is efficacious in treating a prion disease and has a high safety. A remedy for a prion disease which contains a mesenchymal stem cell as the active ingredient and a method of producing the same. A remedy for a prion disease which contains a mesenchymal stem cell, in particular, a mesenchymal stem cell having an anti-prion antibody gene transferred thereinto as the active ingredient and a method of producing the same. These remedies can not only prevent the progress of a prion disease but also contribute to the recovery of nerve dysfunction caused by the disease.

Systems and methods for monitoring phrenic nerve function of a patient are disclosed, including, including establishing a diaphragmatic movement value threshold; positioning a diaphragmatic movement sensor on an external surface of an abdomen of the patient; applying a treatment regimen to a tissue region in proximity to the phrenic nerve; measuring a diaphragmatic movement value with the diaphragmatic movement sensor; comparing the measured diaphragmatic movement value to the established diaphragmatic movement value threshold; and generating an alert in response to the comparison.

The present invention provides a quinolone compound represented by General Formula (1)

or a salt thereof, wherein R₁ represents a hydrogen atom, etc.; R₂ represents a hydrogen atom, etc.; R₃ represents a phenyl group optionally being substituted with one or more substituents, etc.; R₄ represents a halogen atom; R₅ represents a hydrogen atom or halogen atom; R₆ represents a hydrogen atom; and R₇ represents a hydroxyl group, etc. The quinolone compound have a functional improvement effect, which suppresses progression of neurological dysfunction by inhibiting the chronic progression of Parkinson's disease or protecting dopamine neurons from the disease etiology, thereby prolonging the period before first administration begins.

The invention relates to the use of human lysozyme in pharmaceutical industry, in particular the use in preparing medicines for treating dermatosis, infection and ulceration caused by bacteria, fungus, viruses, allergic reaction, and occupational diseases, physical diseases, nerve dysfunctional diseases, and immunity diseases. The invention exploits the novel use of human lysozyme in medical treatment, the gene recombination lysozyme has rich source, the invention also features simple process for manufacturing, and ease in use.

The invention belongs to the technical field of medicine, and concretely relates to caffeoyl substituted pentacyclic triterpenoid derivatives as shown in a formula I and a purpose thereof in preparing medicaments or health products for preventing and treating brain injury and/or neurological dysfunction and/or cognitive dysfunction caused by cerebral ischemia, hypoglycemia and cerebral anoxia. Experiments verify that the derivatives is capable of protecting nerve cells under conditions of hypoglycemia and hypoxia, can substantially improve neurological damage induced by cerebral ischemia, and thus is expected to be developed as medicaments for preventing and treating the brain injury caused by the cerebral ischemia, the hypoglycemia and the cerebral anoxia as well as improving corresponding neuroethology functions.

The invention discloses an evaluation system and method based on neurological function rehabilitation active training, and belongs to the technical field of rehabilitation training. In the system, a qualitative evaluation module classifies and identifies limb actions acquired by a limb action acquisition module based on a limb action processing module, and compares the limb actions with a Brunnstrom scale to obtain a Brunnstrom staging result; a myoelectricity evaluation module is used for carrying out myoelectricity evaluation on a muscle capability diagram obtained by processing myoelectricity signals acquired by a myoelectricity signal acquisition module based on a myoelectricity data processing module; an electroencephalogram evaluation module is used for carrying out brain region evaluation on a brain topographic map and a brain region energy conversion map which are obtained by processing electroencephalogram signals acquired by an electroencephalogram signal acquisition module based on an electroencephalogram data processing module; and a rehabilitation evaluation module combines the Brunnstrom staging result, the myoelectricity evaluation result and the brain region evaluation result for rehabilitation evaluation to obtain a rehabilitation evaluation report. According to the method, the rehabilitation state of the patient can be evaluated accurately and scientifically through the evaluation method of multi-information fusion of electroencephalogram, myoelectricity and postures.

A system includes a guidance device that provides feedback to a user to compress a patient's chest at a rate of between about 90 and 110 compressions per minute and at a depth of between about 4.5 centimeters to about 6 centimeters. The system includes a pressure regulation system having a pressure-responsive valve that is configured to be coupled to a patient's airway. The pressure-responsive valve is configured to remain closed during successive chest compressions in order to permit removal at least about 200 ml from the lungs in order to lower intracranial pressure to improve survival with favorable neurological function. The pressure-responsive valve is configured to remain closed until the negative pressure within the patient's airway reaches about −7 cm H₂O, at which time the pressure-responsive valve is configured to open to provide respiratory gases to flow to the lungs through the pressure-responsive valve.

The invention belongs to the field of biological medicine, and particularly relates to a Nogo-A receptor binding peptide as well as a derivative and an application thereof. The amino acid residue sequence of the Nogo-A receptor binding peptide is HIYTALV or GFATITG. The derivative of the binding peptide is a product obtained through conventional modification of an amino terminal or a carboxyl terminal of a Nogo-A receptor binding peptide fragment on a Nogo-A receptor binding peptide amino acid side chain group or a product obtained by connecting a label used for peptide or protein detection or purification on the Nogo-A receptor binding peptide. The binding peptide and the derivative of the binding peptide can be bound with NgR in vitro, nerve regeneration is promoted by preventing binding of NgR and Nogo-A, nerve regeneration barriers caused by central nervous injury diseases can be treated, recovery of a central nervous function is promoted, and the binding peptide and the derivative can be widely applied in the medical and biological fields.

Standard brain imaging methods portray neurological properties such as perfusion (blood flow), sucrose uptake, or basic anatomical features. These depictions are all secondary to the primary function of the brain which is information processing and computation. The present invention provides for an imaging method based directly on brain function. It images the amounts and changes of information in the function of the brain. This is accomplished my measuring brain information at small time and spatial (anatomical) intervals. At each of these intervals, an informational value is computed. The changes in these values are computed by using known neurophysiological constraints, statistical optimization, or a combination of these two methods. These changes can then be depicted in tomographs, if the user so desires. The result is a clear description of brain function at the primary level.

Methods and apparatuses for sensory electrical stimulation of the peripheral nervous system to improve human motor function and performance are described. Methods and devices may be used to enhance physical performance of athletes, professionals, and gamers or improve motor function (hand, finger and limb movement) in patients rehabilitating from neurological deficits and impairments caused by stroke, traumatic brain injury and other neurologic or non-neurologic conditions. These apparatuses and methods may be used for physical training and mental training (to improve memory and functional performance including motor coordination, limb-eye coordination, occupational and recreational skills) through periodic or sustained sensory electrical stimulation. Treatment plans may be based on biomarkers and may be used alone or in combination with other apparatuses. Learning and feedback techniques individualize treatment parameters depending on the subject's neurologic and motor function in diseased patients and healthy users.

The invention discloses an application of 5,7-dihydroxy-4'-methoxy flavone preparation extracted from snow lotus in preparation of a medicament for treating ischemic stroke. By effectively extracting the 5,7-dihydroxy-4'-methoxy flavone preparation from the snow lotus and establishing an ischemia reperfusion model of a mouse, the influence of acacetin on the infarct volume and the neurologic impairment caused by ischemia reperfusion injury of the mouse is observed. The study carried out by establishing an SH-SY5Y cell OGD model, testing the cell viability and the cell apoptosis, and demonstrating the integral level of the acacetin shows that the acacetin has the effect of significantly reducing the infarct volume, improving the neurologic function score, promoting the cell survival and reducing the cell apoptosis, clarifies that the acacetin has a neurologic protection effect on the cerebral ischemia reperfusion injury and proves that the 5,7-dihydroxy-4'-methoxy flavone preparation can be well applied to preparing the medicament for treating ischemic stroke and has wide application value.

The invention relates to a traditional Chinese medicine preparation for treating craniocerebral trauma and neurologic impairment caused by craniocerebral operations, which can effectively improve cerebral damaged motor nerves. The traditional Chinese medicine preparation is prepared from ginseng, angelica, hoantchy roots, flastem milkvetch seeds, medlar, red sage roots, pearl powder, earthworm, rhizoma gastrodiae, panax notoginseng, grassleaf sweelflag rhizome, hemlock parsley and kudzuvine roots. The preparation method comprises the following steps that: (1) the ginseng, the panax notoginseng, the rhizoma gastrodiae, the kudzuvine roots and the earthworm are broken into particles; the particles are added with ethanol, heated, refluxed, extracted, heated, concentrated and dried to be powder; and herb residue is reserved on standby; (2) the angelica and the hemlock parsley are soaked in water, heated and distilled; volatile oil is extracted; and the herb residue is reserved on standby; (3) the herb residue and residual medicine are combined, added with water and decocted; decoction is combined, filtered, concentrated and spray-dried; and (4) the volatile oil is added with water and beta-cyclodextrin, ground, included, filtered, dried, ground, well mixed with dry powder, sequentially added and well mixed with pearl powder and dextrin, added with the ethanol and dried. The preparation has the advantages of advanced technique, reasonable composition, no toxic-side effect and remarkable treatment effect.