The invention provides a Ti-Nb-Mo-Sn near-beta titanium alloy with low elastic modulus and high strength. The alloy comprises the following chemical components in percentage by weight: 15-35% of niobium, 1-8% of molybdenum, 1-8% of stannum and 0-1.2% of titanium dioxide powder. The Ti-Nb-Mo-Sn near-beta titanium alloy with low elastic modulus and high strength has the beneficial effects that the systemic alloy has good cold machining performance and a low machining cementation index and can coldly deform in a large scale by using cold machining processes such as cold rolling, cold wire drawing and the like; the systemic alloy has the characteristic of nonlinear deformation after being thermally machined or coldly machined and has large restorable elastic strain, low initial modulus and average modulus and high strength; the systemic alloy has low elastic modulus, high yield strength and breaking strength and high linear elasticity after being smelted, thermally machined or coldly machined and thermally treated; and the systemic alloy can be used for preparing medical equipment, physical training equipment and industrial equipment, and can be used for biomedical applications such as artificial bones, bone joints, implanted tooth roots, bony plates and the like.