The invention relates to a biomedical beta-titanium alloy material with low elastic modulus. The preparation method for the material comprises the steps of raw material preparation, raw material smelting, cogging, forging and the like, namely the method comprises the following steps: preparing a raw material alloy of Nb, Zr, Sn, Ta, Mo and Ti according to a certain proportion, mechanically stirring and mixing the alloy, then pressing the alloy on a hydraulic press to form electrodes, and later smelting the electrodes in a vacuum consumable electro-arc furnace to obtain cast ingots of the beta-titanium alloy material; taking out the cast ingots with certain diameter, heating the cast ingots in a vacuum furnace and then preserving the heat, upsetting and drawing out the heated cast ingots on the hydraulic press or a forging device, and repeating the step twice to thrice to obtain a forging stock of the beta-titanium alloy material; heating the forging stock in the vacuum furnace and then preserving the heat, drawing out the heated forging stock on the hydraulic press or the forging device to obtain the biomedical beta-titanium alloy material with the elastic modulus E of 50 to 80GPa. The alloy has the characteristic of low elastic modulus, has good combination properties such as tensile strength, yield strength, corrosion resistance and the like, and does not contain toxic elements to human body.