191 results about "Hydrophilic polymers" patented technology

The invention belongs to the field of lithium resource recovery, and particularly relates to preparation, application and a recovery method of a high-hydrophilicity lithium extraction electrode. The preparation method of the lithium extraction electrode comprises the following steps: sequentially adding a hydrophilic polymer and a cross-linking agent into a solvent, heating and stirring to a homogeneous phase to obtain a binder solution, adding a conductive agent and a lithium extraction active material into the binder solution, uniformly stirring to obtain lithium extraction slurry, coating a current collector with the prepared lithium extraction slurry, and drying to obtain the lithium extraction electrode. And drying to obtain the high-hydrophilicity lithium extraction electrode. The hydrophilic polymer is used for directly bonding the electrode material, so that the electrode is wholly hydrophilic from inside to outside, the prepared electrode material greatly improves the hydrophilicity of the lithium extraction electrode and accelerates the lithium extraction reaction rate, and the electrode material has the characteristics of simple preparation method, low cost, high lithium extraction efficiency, easiness in recovery and environmental protection; and efficient selective lithium extraction can be realized in various lithium-containing solutions.

The present invention relates to a binder composition for a positive electrode comprising a polymer P1 containing repeating units derived from vinylidene fluoride and a hydrophilic polymer P2 containing repeating units derived from at least one monomer of formula R1R2C = C (R3) C (O) R (I) wherein R1, R2 and R3 are independently selected from H and C1-C5 alkyl; r is selected from-NHC (CH3) 2CH2C (O) CH3,-NR 'R "or-OR', where R 'and R" are independently selected from H and C1-C18 alkyl optionally substituted by one or more hydroxyl, thiol or amino functional groups or five to six membered heterocycles comprising at least one nitrogen atom in the ring, characterized in that the hydrophilic polymer P2 has a weight average molecular weight greater than 30000 g / mol, advantageously greater than 50000 g / mol, preferably greater than 65000 g / mol, more preferably greater than 80000 g / mol.

The invention discloses ceramsite lightweight aggregate structural concrete and a preparation method thereof, and belongs to the technical field of concrete. The ceramsite lightweight aggregate structural concrete is prepared from the following raw materials in parts by mass: 240 to 270 parts of cement, 25 to 35 parts of mineral powder, 80 to 95 parts of fly ash, 210 to 250 parts of coal gangue crushed materials, 725 to 805 parts of modified coal gangue ceramsite, 10 to 30 parts of waste rubber materials, 3.5 to 5 parts of water reducing agents and 165 to 180 parts of water. The modified coal gangue ceramsite is obtained by coating the surface of a coal gangue ceramsite matrix with an epoxy resin layer and then grafting a hydrophilic polymer, the porosity of the coal gangue ceramsite matrix is 40-60%, and the aperture ratio is 1.5-6%. The epoxy resin layer on the surface of the modified coal gangue ceramsite provides an anti-permeability barrier, the hydrophilic polymer on the surface adjusts the wettability of the ceramsite, the binding force with other components of the concrete is improved, and the concrete has excellent shrinkage and dry crack resistance.

The invention provides an amphiphilic modified silane coupling agent as well as a preparation method and application thereof, and belongs to the field of material chemistry. The invention provides an amphiphilic modified silane coupling agent preparation method, which comprises: in the presence of an acid-binding agent and a first solvent, carrying out a reaction on a hydroxyl-containing hydrophilic polymer and halogenated acyl halide to obtain an ATRP initiator; in the presence of a metal salt catalyst, a ligand and a second solvent, reacting an ATRP initiator with an acrylate monomer to obtain an active macromolecule containing an amphiphilic group; in the presence of an alkali reagent and a third solvent, the active macromolecules containing the amphiphilic groups react with a silane compound containing amino groups, and the amphiphilic modified silane coupling agent is obtained. The silane coupling agent provided by the invention can be effectively applied to a coating, not only can improve the interface performance between an inorganic matter surface and an organic coating, but also can effectively improve the tensile strength, the waterproof and anti-fouling properties and the tensile strength after re-coating of a coating.

In some aspects, the present disclosure pertains to systems for forming hydrogels that comprise (a) a radiopaque polyamino compound and (b) a reactive polymer comprising a plurality of hydrophilic polymer segments and a plurality of reactive moieties, wherein the reactive moieties are reactive with amino groups of the radiopaque polyamino compound, and wherein the radiopaque polyamino compound is produced by a method that comprises: (i) converting hydroxyl groups of a polyhydroxylated radiopaque compound to amino groups, (ii) converting vicinal diol groups (—CHOHCH2OH groups) of a polyhydroxylated radiopaque compound into hydroxyaminoethyl groups (—CHOHCH2NH2 groups), or (iii) converting vicinal diol groups of a polyhydroxylated radiopaque compound into aminomethyl groups (—CH2NH2 groups). In other aspects, the present disclosure pertains to hydrogels formed from such systems and to methods of treatment using such systems.

A reusable urinary catheter assembly comprises a storage container defining a cavity, a hydration liquid and a reusable urinary catheter. The hydration liquid includes a disinfection medium and a hydrophilic polymer. The viscosity of the hydration liquid is 40 cP or lower. The reusable urinary catheter includes a shaft, and at least a part of the shaft is provided with a hydrophilic surface. During storage, the shaft is enclosed within the cavity in a storage position. The hydration fluid hydrates and regenerates the hydrophilic surface and disinfects the catheter. The catheter is configured to be repeatedly inserted into and removed from the storage container.

The application provides a polymer microsphere profile control water plugging agent and a preparation method and application thereof, and the preparation method comprises the following steps: dispersing molybdenum disulfide nanosheets in water, adding a template carrier to form a Pickering emulsion; performing a first polymerization reaction on the Pickering emulsion, polymer monomer A, a RAFT reagent and an initiator to obtain hydrophilic polymer grafted copolymer nanosheets; performing a second polymerization reaction on the hydrophilic polymer grafted copolymer nanosheets, polymer monomer B and an initiator in a solvent to obtain one-side polymer modified nanosheets; removing the template carrier, and performing a third reaction on the one-side polymer modified nanosheets and amino acids in water to obtain the polymer microsphere profile control water plugging agent. The polymer microsphere profile control water plugging agent prepared by the application is resistant to temperature and salt, can enter deep strata, is uniformly distributed in high-permeability layers, has good profile control and water plugging effects, and can improve recovery efficiency.

The invention provides a hydrophilic modified polytetrafluoroethylene oil removal film and a preparation method thereof. A modified layer of the hydrophilic modified polytetrafluoroethylene oil removal film is mainly prepared from the following raw materials in percentage by mass: 8-12 wt% of a hydrophilic vinyl monomer, 0.3-0.6 wt% of a cross-linking agent, 0.2-0.5 wt% of an initiator and the balance of a deionized water solvent. A new chemical grafting modification strategy is adopted, the surface of the PTFE membrane is activated through low-temperature plasma, co-grafting and cross-linking polymerization of a hydrophilic monomer and a cross-linking agent on the surface of the PTFE membrane are initiated, and a layer of firm hydrophilic polymer brush with a three-dimensional network structure is constructed on the surface of the membrane; a stable hydration layer is formed on a membrane-water interface, the PTFE membrane is endowed with excellent underwater super-oleophobic property, the oil-water separation efficiency, flux and anti-pollution capacity of the PTFE membrane are remarkably improved, the technological process is simple, and the product performance is stable.

The invention relates to the technical field of biomedicine nanotechnology, in particular to a high-stability engineered exosome based on rigid hydrophobic anchoring and micelle disassembly and purification as well as a preparation method and application of the high-stability engineered exosome. According to the invention, a ternary surface structure of rigid hydrophobic anchoring-hydrophilic polymer spacer arm-targeting ligand (L-S-T) is constructed, cholesterol hemisuccinate or multi-branched lipid is selected as an anchoring group, and the problem that conventional phospholipid modification is easy to fall off in vivo and in an albumin-containing preparation is obviously solved; a technology of'micellar insertion after temperature control 'combined with'CMC critical concentration adjustment and purification' is adopted, lossless insertion of functional molecules is realized by utilizing thermodynamic driving force, and residual micelles are induced to be disintegrated into monomers by adjusting the concentration of a system to be lower than the concentration of critical micelles, so that efficient removal of free impurities is realized through conventional ultrafiltration. The engineered exosome has the advantages of long circulation, high targeting and excellent storage stability, and has important clinical application and commercial transformation prospects.

A CO2 separation membrane 22 separates CO2 in air in an indoor environment. A hydrophilic polymer layer 102 includes an amino acid having an amino group and being a CO2 carrier, and an aggregation inhibitor for suppressing aggregation of amino acid. A first porous film 100 carries the hydrophilic polymer layer 102. The aggregation inhibitor contains an alkali metal element. In the hydrophilic polymer layer 102, the substance amount of the alkali metal element is greater than the substance amount of the amino group.

The invention discloses a force-triggered hydrophobic block depolymerization type amphiphilic block polymer as well as a preparation method and application thereof. The force-triggered hydrophobic block depolymerization type amphiphilic block polymer is composed of three parts: a) a mechanochromic group located at the center of two blocks as a trigger depolymerization end, b) a self-degradable hydrophobic block capable of triggering depolymerization, and c) a hydrophilic polymer block. The polymer is obtained by blocking a self-degradation hydrophobic block with a DA chromophore and initiating a hydrophilic monomer to polymerize through an alpha-bromo-ester active end group at the tail end of the chromophore. The centers of the two blocks of the polymer are DA force chromophores, and a force-triggered self-degradable polymer assembly can be constructed through self-assembly in water. Under the action of ultrasonic waves, the DA chromophore end group of the assembly is broken, an r-DA reaction is induced, a furan carbonate end-capped self-degradable polymer is generated, the end group is quickly decomposed, a continuous elimination reaction is immediately triggered to depolymerize a hydrophobic block, the assembly is promoted to be degraded, and the assembly is used as a carrier material for controllably releasing drugs.

The invention belongs to the technical field of taxifolin, and discloses a taxifolin compound, a preparation method thereof and application of the taxifolin compound in the fields of relieving, oil control and senility .The taxifolin compound contains modified beta-cyclodextrin, taxifolin and auxiliary components, and the modified beta-cyclodextrin is modified through a polar group; the auxiliary component is selected from one or more of a hydrophilic polymer, an antioxidant and a targeting carrier. The taxifolin compound provided by the invention is high in inclusion rate and good in water solubility, the polar group modified beta-cyclodextrin can finely adjust the space structure of a cavity to expand an opening, the polar group modified beta-cyclodextrin has high matching degree with the molecular structure of taxifolin, a hydrophobic aromatic ring of taxifolin can enter the cavity to be combined with a hydrophobic core, and the taxifolin compound is high in inclusion rate and good in water solubility. The water solubility is good. The taxifolin compound provided by the invention is strong in anti-inflammatory ability, has a remarkable soothing effect, and also has excellent anti-aging and oil-control effects.

The present invention is an implantable medical device comprising (i) a base coat layer having an inner and outer surface, the inner surface of the base coat layer contacting the implantable medical device; (ii) a top-coat layer of a hydrophilic polymer chemically crosslinked and covalently bonded to the outer surface of the base coat layer, the hydrophilic polymer comprising an anionic polyelectrolyte; and (iii) an amount of a hydrophilic cationic drug agent added to the top-coat layer sufficient to provide an effective dosage of the drug agent for delivery to a patient, whereby the hydrophilic cationic drug agent is initially adsorbed into the anionic polyelectrolyte of the top-coat layer and the hydrophilic cationic drug agent having a release rate after the medical device is implanted within a patient's body.

The invention discloses deep-eutectic solvent supramolecular gel, a preparation method thereof and application of the deep-eutectic solvent supramolecular gel in DNA room-temperature storage, and belongs to the technical field of biological material storage. The deep-eutectic solvent supramolecular gel for embedding DNA provided by the invention comprises a deep-eutectic solvent matrix, a supramolecular gel agent and a DNA-positive salt compound water phase, the DNA-electropositive salt compound water phase is an upper phase solution obtained by mixing a DNA water solution with a hydrophilic polymer and electropositive salt and then carrying out phase separation. The deep-eutectic solvent supramolecular gel provided by the invention can effectively encapsulate DNA, can resist high temperature, enzymolysis, free radicals, microorganisms and the like erosion, and is beneficial to realizing long-term stable storage of the DNA at room temperature.

The application provides a zwitterionic brush double hydrogel surface modified polytetrafluoroethylene (PTFE) hydrophilic antifouling hollow fiber membrane and a preparation method thereof, which can significantly improve the hydrophilicity and antifouling performance of the PTFE hollow fiber membrane. The preparation method comprises the following steps: step 1, putting pretreated PTFE membrane filaments into a PVA solution for immersion; step 2, immersing a glutaraldehyde / citric acid solution; step 3, balancing in water; step 4, immersing a PIC hydrogel solution; step 5, immersing an iron ion-containing solution again; and step 6, balancing in water. The modification method can significantly improve the water flux of the PTFE hollow fiber membrane, and the modified double hydrophilic polymer has high antifouling performance.

Provided are hydrophilic substrates provided with a hydrophilic polymer layer having controlled surface uniformity and irregularities, and methods for preparing the hydrophilic substrates. Included are hydrophilic substrates including a substrate having a surface containing at least one group represented by —N(R1)2 or —N(R2)3+ wherein each R1 or R2 is the same or different and represents a hydrogen atom or a substituted or unsubstituted hydrocarbon group optionally containing a hetero atom; and a hydrophilic polymer layer provided on the surface of the substrate.

The soil to be treated is assumed to be particularly water-containing soil such as construction sludge, which is difficult to solidify, and a soil conditioner is provided that improves the quality of the water-containing soil, thereby making it easier to handle, such as by transporting it. [Solution] A soil conditioner for modifying moist soil present in civil engineering or construction work, or soil improvement work, comprising a volume reduction agent that reduces the amount of inorganic preparation used on moist soil to reduce the volume of the modified soil, the volume reduction agent being a polymer preparation, the polymer preparation being at least one selected from the group consisting of hydrophilic polymers, water-absorbent polymers, and polymer flocculants, and the inorganic preparation comprising at least one selected from the group consisting of cement, quicklime, gypsum, paper sludge ash, and magnesium oxide.

The application discloses a kind of charged hydrophilic polymer porous membrane, its preparation method and application in polysaccharide concentration purification in Chinese herbal medicine, belong to porous membrane technical field.It includes: while the non-solvent phase separation of film-forming polymer solution and the formation of separation layer on the outer surface of polymer membrane, simultaneously coating water-soluble coating layer polymer solution on the surface of separation layer, obtain charged hydrophilic polymer porous membrane;Film-forming polymer solution uses fluorine-containing polymer as film-forming base material, uses nitrogen-containing small molecule as first solvent, uses macromolecular organic matter as pore-forming agent.The application is applied to polysaccharide concentration purification in Chinese herbal medicine, solve the problem that the membrane surface opening rate is low, hydrophilic and poor negative charge of existing non-solvent phase separation technology is not applicable to polysaccharide concentration purification in Chinese herbal medicine, the opening rate of charged hydrophilic polymer porous membrane prepared is high, cutting molecular weight is 10-1000kDa, and can realize membrane forming, improve surface opening rate and surface hydrophilic negative charge modification simultaneously.

The application discloses a responsive fluorescent / phosphorescent dual-mode carbon quantum dot composite material, and is characterized in that biomass such as yacon peel is used as a carbon source, ethylenediamine is used as a nitrogen source, nitrogen-doped carbon quantum dots are prepared through a one-step hydrothermal method, the nitrogen-doped carbon quantum dots and hydrophilic polymers are uniformly dispersed in deionized water to obtain the responsive fluorescent carbon quantum dot composite material, and the ink prepared by using the composite material has the following characteristics: the printed pattern is invisible under natural light, can display cyan fluorescence under ultraviolet light, presents green phosphorescence after the ultraviolet light is removed, and can realize fluorescent / phosphorescent dual-mode anti-counterfeiting functions. 3+ In addition, the printed pattern can undergo fluorescence quenching under alkaline solution or Fe 3+ solution, realizes dynamic response anti-counterfeiting functions, and solves the problems that the existing carbon quantum dots have single light-emitting mode and are difficult to have dynamic response and dual-mode light-emitting functions.

The invention discloses a total heat exchange membrane and a preparation method thereof, the total heat exchange membrane comprises: a compact layer, the compact layer comprises a hydrophilic polymer substrate and an MXene functional filler, the hydrophilic polymer substrate comprises one or more of polyvinyl alcohol, polyvinylpyrrolidone, polyurethane and polyacrylic resin; the MXene functional filler is an MXene material subjected to antibacterial modification treatment; the porous support layer is coated with the compact layer, and the porous support layer is prepared from a polymer membrane material subjected to hydrophobic modification treatment. The total heat exchange membrane comprises a compact layer and a porous supporting layer, and the compact layer comprises a hydrophilic polymer base material and antibacterial modified MXene functional filler, so that high moisture permeability and antibacterial property of the total heat exchange membrane can be realized; the porous supporting layer is prepared from a polymer film subjected to hydrophobic modification treatment, has hydrophobicity, reduces adhesion of water molecules, and can reduce mass transfer resistance.

The application relates to the field of high-molecular polymer materials, and particularly discloses a preparation method of a high-penetration alloy hollow fiber ultrafiltration membrane with a twist structure, which comprises the following steps: (1) preparation of a twist structure-containing polyarylether sulfone; (2) preparation of a casting solution; and (3) preparation of the alloy hollow fiber ultrafiltration membrane.The high-penetration alloy hollow fiber ultrafiltration membrane prepared by the method adopts twist structure-containing rigid S-PAES, hydrophobic fluorine-containing S-PAES is blended with hydrophilic PVP, after the casting solution is solidified into a hollow fiber membrane form, specific hydrophilic holding post-processing is adopted, chemical reactions between groups are used to form stable covalent structures between the hydrophilic polymers, and the hydrophilic durability of the alloy ultrafiltration membrane is maintained.

An electrode, a method of producing it, and a fuel cell with such elec- trode In a method of producing electrodes (20), for example for fuel cells, two aqueous coatings (15, 16) are subsequently applied onto a porous hydrophobic electroconductive substrate (10). A first coating containing a sacrificial hydrophilic polymer, for example HEC and / or PPC, is applied for temporarily hydrophilizing the substrate surface. For providing a catalyst layer, CL, a second coating is applied on the first coating. The sec- ond coating comprises an electroconductive filler and a catalyst and water soluble polymeric binders, for example PVA and HPC. By heating the coatings, the sacrificial pol- ymer decomposes and evaporates and binds the catalyst layer to the substrate.

A cervical dilator comprises a stem comprising a partially or completely dehydrated hydrogel comprising a water-insoluble synthetic hydrophilic polymer capable of radial expansion due to absorption of water from bodily fluids. The cervical dilator softens and matures cervical tissue and dilates the cervical canal through a combination of radial hydrogel stem expansion and osmotic absorption of water from the tissue. The osmotic absorption is caused by at least one osmotically active compound, such as a water-soluble salt, polyelectrolyte, or mixtures thereof, dispersed within the hydrogel. The cervical dilator may also include a non-toxic plasticizer for the hydrogel, such as water.

A lithographic printing plate precursor has an aluminum substrate prepared using two anodization processes to provide an inner aluminum oxide layer having an average dry thickness of 300-3,000 nm and having a plurality of inner micropores having an average inner micropore diameter of <100 nm. An outer aluminum oxide layer is provided with a plurality of outer micropores having an average outer micropore diameter of 15-30 nm and a dry thickness of 30-650 nm. A hydrophilic layer is provided on the outer aluminum oxide layer having (1) a compound having an ethylenically unsaturated polymerizable group, an -OM group directly attached to a phosphorus atom, wherein M represents a hydrogen, sodium, potassium, or aluminum atom; and (2) one or more hydrophilic polymers having (a) a repeating unit comprising an amide group, and (b) a repeating unit having an -OM' group directly attached to a phosphorus atom, wherein M' represents a hydrogen, sodium, potassium, or aluminum atom. 2 An outer aluminum oxide layer is provided with a plurality of outer micropores having an average outer micropore diameter of 15-30 nm and a dry thickness of 30-650 nm. A hydrophilic layer is provided on the outer aluminum oxide layer having (1) a compound having an ethylenically unsaturated polymerizable group, an -OM group directly attached to a phosphorus atom, wherein M represents a hydrogen, sodium, potassium, or aluminum atom; and (2) one or more hydrophilic polymers having (a) a repeating unit comprising an amide group, and (b) a repeating unit having an -OM' group directly attached to a phosphorus atom, wherein M' represents a hydrogen, sodium, potassium, or aluminum atom.

The invention discloses a charged hydrophilic polymer porous membrane, a preparation method thereof and application of the charged hydrophilic polymer porous membrane in concentration and purification of polysaccharides in Chinese herbal medicines, and belongs to the technical field of porous membranes. Comprising the following steps: synchronously coating a water-soluble coating layer polymer solution on the surface of a separation layer while a film-forming polymer solution is subjected to non-solvent-induced phase separation and the separation layer is formed on the outer surface of a polymer film, so as to obtain a charged hydrophilic polymer porous film; the film-forming polymer solution takes a fluorine-containing polymer as a film-forming base material, a nitrogen-containing small molecule as a first solvent and a high-molecular organic matter as a pore-forming agent. The charged hydrophilic polymer porous membrane is applied to the aspect of concentration and purification of polysaccharide in Chinese herbal medicine, the problem that a membrane prepared by an existing non-solvent induced phase separation technology is low in surface aperture ratio and poor in hydrophilicity and charge electronegativity and is not suitable for concentration and purification of polysaccharide in Chinese herbal medicine is solved, the prepared charged hydrophilic polymer porous membrane is high in aperture ratio, the cutting molecular weight is 10-1000 kDa, and the specific surface area of the membrane is larger than that of the existing non-solvent induced phase separation technology. And membrane forming, surface aperture ratio improvement and surface hydrophilic negatively-charged modification can be realized at the same time.

To provide a pharmaceutical composition for cancer treatment which shows a synergistic cancer therapeutic effect when used in combination with an anti-tumor agent, and can be easily used as a cancer therapeutic agent and a combination therapeutic pharmaceutical.SOLUTION: Provided is a cancer treatment application of nanoparticles containing a slightly soluble camptothecin-based compound and a combined administration therapy with an anti-tumor agent using the application. In one embodiment, a combination pharmaceutical preparation for pancreatic cancer treatment contains: particles including SN-38(7-ethyl-10-hydroxycamptothecin), irinotecan, and an amphiphilic block copolymer made of a hydrophobic block and a hydrophilic block; and one or more kinds of anti-tumor agents selected from the group consisting of nab-paclitaxel as an active ingredient, the amphiphilic block copolymer being constituted of A-B or A-B-A block, (a) A is a hydrophilic polymer and is monomethoxypolyethylene, and (b) B is a hydrophobic polymer and is poly-D,L-lactide or a derivative thereof.SELECTED DRAWING: Figure 2

The invention provides water-retaining hydrogel based on a super-hydrophilic polymer as well as a preparation method and application of the water-retaining hydrogel. The water-retaining hydrogel comprises a super-hydrophilic polymer unit and a unit derived from a cross-linking agent. The water retention hydrogel based on the super-hydrophilic polymer has excellent water retention capacity; besides, the water-retaining hydrogel also keeps the inherent flexibility, conductivity and biocompatibility of the hydrogel, is good in universality, can adapt to various complex conditions, not only is beneficial to prolonging the service life of the sensor, but also can keep the stable sensing capacity under various complex environmental conditions, and has a good application prospect. The application range of the hydrogel sensor in the field of flexible electronics is further expanded.

The application belongs to the field of biological medicine, and particularly relates to a lipid-hydrophilic polymer and a preparation method and application thereof. The lipid-hydrophilic polymer provided by the application has a structure shown in formula (I), wherein R1 is a hydrophilic polymer group with a polymerization degree of 20-50, R2 is a C2-C4 alkyl group, R3 is a C2-C4 alkyl group, R4 is a hydrophobic lipid group with a single tail or a C-C double tail, L1 is an ester bond, and L2 is an amide bond or an ester bond. The application introduces a dithiole-sensitive chemical bond between the hydrophilic polymer and the lipid by molecular structure design, and obtains a breakable lipid-hydrophilic polymer. On this basis, by increasing the mole percentage of the lipid-hydrophilic polymer in the lipid nanoparticle, high-efficiency transfection can be realized while the stability of the lipid nanoparticle is enhanced. 10 ~C 22 single tail or C 10 ~C 22 double tail hydrophobic lipid group, L1 is an ester bond, and L2 is an amide bond or an ester bond. The application introduces a dithiole-sensitive chemical bond between the hydrophilic polymer and the lipid by molecular structure design, and obtains a breakable lipid-hydrophilic polymer. On this basis, by increasing the mole percentage of the lipid-hydrophilic polymer in the lipid nanoparticle, high-efficiency transfection can be realized while the stability of the lipid nanoparticle is enhanced. Formula (I).

The problem is to provide a porous membrane with a reduced phenomenon in which membranes firmly adhere to one another during production of the porous membrane (membrane adhesion). The problem is solved by a porous membrane comprising a hydrophobic polymer and a hydrophilic polymer, wherein an average value T of ratios of the number of counts of ions derived from the hydrophilic polymer to the number of counts of ions derived from the hydrophobic polymer is 1.0 or more when a surface of the porous membrane is measured by time-of-flight secondary ion mass spectrometry (TOF-SIMS).

The invention discloses a hydrophilic coating composition, a hydrophilic coating reagent and a preparation method of a hydrophilic coating, and belongs to the technical field of hydrophilic coatings. The hydrophilic coating comprises a bottom coating which is coated on the catheter and is formed after the bottom coating is cured, and a surface coating which is coated on the bottom coating and is formed after the surface coating is cured. The prime paint comprises the following components in percentage by mass: 1-15 wt% of a cross-linking agent, 0.05-1 wt% of a second initiator, 0.5-2 wt% of a wetting agent and a solvent; the surface layer coating is prepared from the following components in percentage by weight: 1 to 15 percent of curable hydrophilic polymer, 0.02 to 0.8 percent of first initiator, 0.2 to 5 percent of adhesive, 0.01 to 0.5 percent of antioxidant and solvent. The hydrophilic coating can be firmly adhered to the surface of an instrument and has good ageing resistance and lubricity.