The invention relates to the fields of
biotechnology, traditional Chinese medicines and nutritional health-care products, in particular to a
bifidobacterium breve-containing medicinal and edible composite composition and application thereof in preparation of products for preventing or treating
anxiety and depression, improving sleep disorders and assisting in
weight management. The composite composition is prepared from
bifidobacterium breve and a medicinal and edible composition, and the ratio of the
bifidobacterium breve to the medicinal and edible composition is 1 * 10 < 10 > CFU of the
bifidobacterium breve and 60 g of the medicinal and edible composition. The composition disclosed by the invention has a remarkable synergistic effect, can effectively prevent or relieve
anxiety and depression symptoms, can improve
sleep quality, and can assist in reducing
body weight and body fat. The action mechanism relates to double targets of'intestine-brain-metabolic axis', and the double targets supplement each other to synergistically promote nerve-
immunity-endocrine and
metabolic balance. The composition disclosed by the invention can be used for preparing medicines, functional foods or health-care products, and provides a safe and effective brand-new choice for intervention of multiple
health problems (emotion, sleep and metabolic disorders).