11 results about "Immune modulation" patented technology

The present disclosure provides dual functioning compounds, compositions, formulations, and methods for inducing or modulating an immune or inflammatory response and treating diseases or disorders (e.g., cancer, autoimmune diseases, inflammatory diseases, and infectious diseases) with the compounds or compositions thereof. In particular disclosed herein are dual functioning compounds comprising a stimulator of interferon (IFN) genes (STING) agonist moiety and a second active moiety selected from an indoleamine 2,3-dioxygenase (IDO) inhibitor and phosphatidylinositol 3‑kinase (PI3K) inhibitor, and compositions and formulations thereof.

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a polysaccharide extraction method, a Qi-II ointment formula capable of invigorating the spleen, replenishing Qi, enhancing immunity and resisting fatigue and a preparation method of the Qi-II ointment formula. The paste is prepared from astragalus membranaceus, codonopsis pilosula, Chinese yam, poria cocos, lotus seeds, rhizoma polygonati, red dates, coix seeds, lily, liquorice and fructus psoraleae as raw materials through the processes of raw material pretreatment, water extraction-alcohol extraction synergistic extraction, beta-cyclodextrin inclusion and concentration paste collection, sterilization and filling. Wherein L-tartaric acid is adopted to regulate the pH value of an extracting solution, and polysaccharide is promoted to be directionally degraded into low-molecular active fragments; bitter and astringent taste of saponin components is masked by using a beta-cyclodextrin inclusion technology, the taste is improved, and the bioavailability is improved; and the product stability is enhanced through combination of vacuum dehydration and dynamic sterilization. The cream has the functions of invigorating spleen, replenishing qi, regulating immunity and resisting fatigue, is sweet and moist in taste and high in safety, and has a wide application prospect.

The present invention relates to bacterial probiotics useful in aquaculture. Specifically, it discloses a selection of non-hemolytic, proteolytic, stress-tolerant bacterial strains with enhanced quorum- quenching capabilities. Moreover, the method allows detection of novel species of bacteria whose probiotic attributes could be massive for aquaculture. From the isolated bacteria, selected species were tested for their probiotic efficacy in Nile tilapia (Oreochromis niloticus), a key fish species in global finfish aquaculture. The species demonstrated significant efficacy in improving the health and growth performance of Nile tilapia juveniles. Specific growth rates and weight gain, and improved feed conversion ratios without adverse effects on fish health were observed. The gut microbiome was positively influenced by promoting beneficial bacteria while reducing harmful (opportunistic) species, leading to improved immune modulation. Survival rates were significantly boosted during a pathogenic challenge, and key immune genes were upregulated, indicating stronger local immune defenses. These findings show that the selected probiotic species offer substantial benefits for growth, feed efficiency, and disease resistance, emphasizing their potential for widespread application as probiotics in aquaculture.

The invention relates to a preparation method of SOD (superoxide dismutase) active wine. The preparation method comprises the following steps: (1) preparing a Cu / Zn-SOD stock solution from rumex hanus, agrimonia pilosa, folium mori, rosa roxburghii tratt and pawpaw; the preparation method comprises the following steps: preparing Fe / Mn-SOD stock solution from horseradish tree leaves, soybeans, wheat and corn; preparing an EC-SOD stock solution from inonotus obliquus, hericium erinaceus, agaric, lucid ganoderma and ganoderma sinensis; (2) quantitatively blending the three SOD stock solutions according to a certain activity ratio to prepare an SOD combined stock solution; and (3) mixing and blending the combined stock solution and the base wine, filtering, and standing to prepare the SOD active wine. The preparation method has the advantages that the SOD stock solution is applied to preparation of wine products, so that the SOD wine has unique taste and flavor and has the effects of regulating immunity, resisting oxidation and improving sleep quality.

This invention discloses a medicinal and edible herbal paste made from Sichuan pepper and perilla seeds to enhance immunity, and its preparation method. It relates to the field of functional food technology and is made from the following raw materials in parts by weight: 3-8 parts Sichuan pepper extract, 12-25 parts perilla seed oil extract, 1-3 parts dried tangerine peel extract, 1-2 parts ginger extract, 8-15 parts erythritol, 10-20 parts isomaltitol, 0.1-0.3 parts xanthan gum, 40-60 parts purified water, and 0.5-1.5 parts licorice extract. This invention features innovative formulation and significant synergistic effects: Following the principles of "yin-yang balance and complementary warming and cooling" in traditional Chinese medicine, this invention scientifically combines Sichuan pepper (which warms and dispels cold) with perilla (which moistens and nourishes yin), achieving a balance of warming and moistening, dispersing and astringing, and yin-yang complementarity. The Sichuan pepper extract and perilla seed oil extract work synergistically in a weight ratio of 5:18, which not only enhances the immune-regulating effect but also avoids the pungent and drying properties of Sichuan pepper that can damage yin and the greasy nature of perilla. Studies have shown that the combination of Sichuan pepper, perilla, and ginger can synergistically improve antioxidant activity.

Disclosed are methods and compositions related to treatment, amelioration or prevention of cachexia or inflammation related to cachexia in a subject. As disclosed, cachexia or inflammation related to cachexia can be treated, ameliorated or prevented by the administration of an effective amount of a composition including immune-modulating fibroblasts to the subject.

Disclosed is a production method of a product that is developed for treatment of hair loss, alopecia areata (pelade or ringworm), androgenetic alopecia (AGA), hair follicle nourishment, scalp nourishment and scar, scar tissue, eczema, acne treatments, for neurodegenerative, inflammatory diseases and for immune modulation purposes (regulation of the immunological response against inflammation of human tissues and fluids, for regeneration purposes). In particular, the disclosed is a method for the production of a chemical-free product with amniotic fluid content, which has been standardized by pooling and then freeze-dried and gamma irradiated (pooled / cocktail and gamma irradiated amnion-OTIA 1.0), that has been developed to be used in the treatment of ailments such as hair loss, alopecia areata (pelade), androgenetic alopecia (AGA), hair follicle nutrition, scalp nourishment, scar, scar tissue, eczema and acne.

The invention relates to the technical field of plant compound extracts, in particular to a plant compound extract with immunoregulation and anti-hypoxia functions as well as a preparation method and application of the plant compound extract. The invention provides a plant compound extract with immunoregulation and anti-hypoxia functions, which is prepared from the following raw materials in parts by mass: 0.5 to 1.5 parts of radix fici simplicissimae, 0.5 to 1.5 parts of longan, 0.5 to 1.5 parts of fructus lycii, 0.5 to 1.0 part of rhizoma dioscoreae, 0.3 to 0.8 part of poria cocos, 0.4 to 0.6 part of fructus momordicae, 0.2 to 0.4 part of herba cistanche and 50 parts of water. The plant compound extract has immunoregulation and anti-hypoxia functions at the same time.

This disclosure describes a cannabinoid-based nanoplatform for treating shingles, designed to enhance bioavailability and controlled release of active ingredients. The composition includes cannabinoids like cannabidiol (CBD) and cannabigerol (CBG), alongside flavonoids, polyphenols, and alkaloids, in oral and topical formulations. The oral capsule combines cannabinoids with polyphenols and flavonoids to provide systemic anti-inflammatory, antiviral, and neuroprotective effects, particularly for nerve pain and inflammation, including postherpetic neuralgia. The topical cream includes cannabinoids, capsaicin, and aloe vera, offering localized relief from pain, itching, and rash. The method targets both systemic and localized symptoms during the acute phase of shingles, aiming to inhibit varicella-zoster virus replication, disrupt viral assembly, and prevent viral release, while also providing immune modulation and anti-inflammatory benefits. The nanoplatform uses nano-emulsification techniques, producing particles smaller than 200 nm to ensure optimal delivery and therapeutic efficacy, offering comprehensive relief for shingles symptoms.

The invention provides a Chinese herbal medicine functional additive for shrimp breeding feed as well as a preparation method and application of the Chinese herbal medicine functional additive, and belongs to the technical field of feed additives. The Chinese herbal medicine functional additive is prepared from the following raw materials in parts by mass: 10 to 15 parts of honeysuckle flower, 10 to 15 parts of fructus forsythiae, 15 to 20 parts of radix isatidis, 20 to 30 parts of radix astragali seu hedysari, 8 to 12 parts of radix platycodonis, 5 to 10 parts of Chinese gall, 10 to 15 parts of herba taraxaci and 8 to 12 parts of rhizoma polygoni cuspidati. Honeysuckle, gallnut and polygonum cuspidatum in the formula have the bacteriostatic effect, fructus forsythiae and isatis root can be used for resisting viruses, astragalus membranaceus can enhance the immunity of the organism, platycodon grandiflorum can promote intestinal development and improve digestion and absorption, dandelion has the effects of protecting liver, benefiting gallbladder and resisting inflammation, and after the Chinese herbal medicines are combined, the synergistic effects of resisting bacteria, resisting viruses and regulating immunity are achieved; the immunity of the shrimps and the digestion and absorption capability of the feed can be improved, and rapid and healthy growth of the shrimps is promoted.

The present invention relates to the efficient delivery of anti-infective activity, immune modulators, or growth-promoting biomolecules directly to the gastrointestinal tract of animals via a biodelivery platform.SOLUTION: The biodelivery platform can be a genetically modified microorganism. Delivery can be achieved using Lactobacillus species fix in the gastrointestinal tract. The anti-infective activity can be a bactericidal or bacteriostatic peptide, an antibody or fragment thereof that specifically recognizes a pathogen, or a phage or lytic peptide derived from a phage that specifically targets a particular pathogen.SELECTED DRAWING: None