2 results about "Immune modulation" patented technology

The present invention relates to bacterial probiotics useful in aquaculture. Specifically, it discloses a selection of non-hemolytic, proteolytic, stress-tolerant bacterial strains with enhanced quorum- quenching capabilities. Moreover, the method allows detection of novel species of bacteria whose probiotic attributes could be massive for aquaculture. From the isolated bacteria, selected species were tested for their probiotic efficacy in Nile tilapia (Oreochromis niloticus), a key fish species in global finfish aquaculture. The species demonstrated significant efficacy in improving the health and growth performance of Nile tilapia juveniles. Specific growth rates and weight gain, and improved feed conversion ratios without adverse effects on fish health were observed. The gut microbiome was positively influenced by promoting beneficial bacteria while reducing harmful (opportunistic) species, leading to improved immune modulation. Survival rates were significantly boosted during a pathogenic challenge, and key immune genes were upregulated, indicating stronger local immune defenses. These findings show that the selected probiotic species offer substantial benefits for growth, feed efficiency, and disease resistance, emphasizing their potential for widespread application as probiotics in aquaculture.

This invention discloses a medicinal and edible herbal paste made from Sichuan pepper and perilla seeds to enhance immunity, and its preparation method. It relates to the field of functional food technology and is made from the following raw materials in parts by weight: 3-8 parts Sichuan pepper extract, 12-25 parts perilla seed oil extract, 1-3 parts dried tangerine peel extract, 1-2 parts ginger extract, 8-15 parts erythritol, 10-20 parts isomaltitol, 0.1-0.3 parts xanthan gum, 40-60 parts purified water, and 0.5-1.5 parts licorice extract. This invention features innovative formulation and significant synergistic effects: Following the principles of "yin-yang balance and complementary warming and cooling" in traditional Chinese medicine, this invention scientifically combines Sichuan pepper (which warms and dispels cold) with perilla (which moistens and nourishes yin), achieving a balance of warming and moistening, dispersing and astringing, and yin-yang complementarity. The Sichuan pepper extract and perilla seed oil extract work synergistically in a weight ratio of 5:18, which not only enhances the immune-regulating effect but also avoids the pungent and drying properties of Sichuan pepper that can damage yin and the greasy nature of perilla. Studies have shown that the combination of Sichuan pepper, perilla, and ginger can synergistically improve antioxidant activity.