Targeted innate immunity

a technology of innate immunity and immune system, applied in the field of cancer therapy agents and methods, can solve the problems of limited immunotherapy attempts, inadequate immune response,
US20060135459A1Inactive Publication Date: 2006-06-22UNIV OF SOUTHERN CALIFORNIA
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
UNIV OF SOUTHERN CALIFORNIA
Publication Date
2006-06-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

Provided is a cancer therapeutic agent comprising a cancer targeting molecule linked to a CpG oligodeoxynucleotide. Also provided are methods of reducing the size of a tumor or inhibiting the growth of cancer cells in an individual or inhibiting the development of metastatic cancer, comprising administering an effective amount of the cancer therapeutic agent. The methods may also include reducing immunoregulatory T cell activity in the individual.
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Description

CROSS REFERENCE TO RELATED PATENT APPLICATIONS

[0001] This application claims priority under 35 U.S.C. §119(e) to U.S. application Ser. No. 60 / 626,829, filed Nov. 9, 2004, incorporated herein by reference in its entirety.BACKGROUND OF THE INVENTION

[0002] The invention relates to cancer therapeutic agents and methods for cancer therapy.

[0003] The following discussion of the background of the invention is merely provided to aid the reader in understanding the invention and is not admitted to describe or constitute prior art to the present invention.

[0004] Surgery, radiation therapy, and chemotherapy have been the standard accepted approaches for treatment of cancers including leukemia, solid tumors, and metastases. Immunotherapy (sometimes called biological therapy, biotherapy, or biological response modifier therapy), which uses the body's immune system, either directly or indirectly, to shrink or eradicate cancer has been studied for many years as an adjunct to conventional cance...

Claims

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