45results about How to "Better shifting" patented technology

A hydraulically powered tractor includes an elongated body, two gripper assemblies, at least one pair of aft and forward propulsion cylinders and pistons, and a valve system. The valve system comprises an inlet control valve, a two-position propulsion control valve, a two-position gripper control valve, two cycle valves, and two pressure reduction valves. The inlet control valve spool includes a hydraulically controlled deactivation cam that locks the valve in a closed position, rendering the tractor non-operational. The propulsion control valve is piloted on both ends by fluid pressure in the gripper assemblies. The propulsion control valve controls the distribution of operating fluid to and from the propulsion cylinders, such that one cylinder performs a power stroke while the other cylinder performs a reset stroke. Each end of the gripper control valve is piloted by a source of high-pressure fluid selectively admitted by one of the cycle valves. The gripper control valve controls the distribution of operating fluid to and from the gripper assemblies. The cycle valves are spring-biased and piloted by fluid pressure in the propulsion cylinders, so that the gripper control valve shifts only after the cylinders complete their strokes. The pressure reduction valves limit the pressure within the gripper assemblies. These valves are spring-biased and piloted by the pressure of fluid flowing into the gripper assemblies. Some or all of the valves include centering grooves on the landings of the spools, which reduce leakage and produce more efficient operation. The propulsion control and gripper control valves include spring-assisted detents to prevent inadvertent shifting.

Embodiments of the present invention include a method for providing a secure domain name system (DNS) for machine to machine communications. In one embodiment, the method includes storing policy information for machine to machine communications in a global DNS registry database server. The method further includes communicating the policy information for machine to machine communications from the global DNS registry database server to a machine DNS registry server located in an Internet service provider (ISP) network, wherein a control signaling gateway located in the ISP network is configured to utilize the policy information for machine to machine communications to allow only registered controllers associated with a machine to communicate with the machine.

A maritime energy generating device including a windmill mounted on a floating foundation, the windmill having a machine compartment mounted at the top of a tower and the foundation being fixed to the bottom of a water body by a connection and including two tanks and a unit for shifting liquid between the tanks and the tanks and the surroundings.

A surgical instrument (10) is provided that includes a handle (18) defining a longitudinal axis (20). The handle has an outer surface (22) including a plurality of longitudinal fins (24) that define a plurality of longitudinal grooves (26) therebetween. At least one of the longitudinal fins may project radially from the outer surface of the handle. A pair of the fins may project radially from the outer surface of the handle and are diametrically opposed. A pair of the fins may be opposed and disposed in a plane tangential to the outer surface of the handle. Two separate pairs of the fins can project radially from the outer surface of the handle and are diametrically disposed. The two separate pairs are offset 90° relative to the longitudinal axis. Two separate pairs of the fins can be opposed and disposed in alternate planes tangential to the outer surface of the handle.

A fastening assembly for a sensor assembly has a metal bush and a fastener. It is possible for the metal bush to be connected via the fastener to a vehicle body. The sensor assembly includes at least one sensor module and an associated sensor assembly. The metal bush has a sleeve as a single-point fixing and a plate as a carrier unit for a carrier plate on which the at least one sensor module is arranged. The sleeve is led through a central through-passage in the carrier plate.

A control device for an electric power steering apparatus has a motor which applies a steering assist force and a driving control device which drives the motor, the driving control device has a gate driving circuit which drives a motor driving bridge circuit based on a command from a computer, the power supply portion of the gate driving circuit has a voltage limit unit, and there is provided with a function of driving the lower side driving elements of the motor driving bridge circuit when the voltage limit unit detects the abnormally high voltage of the power supply voltage.

A hydraulically powered tractor adapted for advancement through a borehole including an elongate body, aft and forward gripper assemblies, and a valve control assembly housed within the elongate body. The aft and forward gripper assemblies are adapted for selective engagement with the inner surface of the borehole. The valve control assembly includes a gripper control valve for directing pressurized fluid to the aft and forward gripper assemblies. The valve control assembly also includes a propulsion control valve for directing fluid to an aft or forward power chamber for advancing the body relative to the actuated gripper assembly. Aft and forward mechanically actuated valves may be provided for controlling the position of the gripper control valve by detecting and signaling when the body has completed an advancement stroke relative to an actuated gripper assembly. Aft and forward sequence valves may be provided for controlling the propulsion control valve by detecting when the gripper assemblies become fully actuated. Furthermore, a pressure relief valve is preferably provided along an input supply line for limiting the pressure of the fluid entering the valve control assembly.

The present invention describes the use of leptin for the immune modulation of the Th1 / Th2 response. One aspect of the invention provides for a shift in the Th1 / Th2 cell balance towards pro-inflammatory cytokine producing cells. This shift results from an increase in the levels, expression and / or the activity of leptin. Another aspect of the invention provides for a shift in the Th1 / Th2 cell balance towards anti-inflammatory cytokine producing cells. This shift results from a decrease in the levels, expression and / or the activity of leptin. The shifting of the Th1 / Th2 balance provides a method for the treatment of a variety of diseases and disorders.

Leptin was previously demonstrated to exert potent immune modulatory properties in several immune mediated disorders. The aim of the study was to determine leptin's anti-tumor effect in a murine model of human hepatocellular carcinoma (HCC). In vivo, Athymic T cell deficient (nude) mice transplanted with 1×106 human Hep3B cells, followed by administration of two daily intraperitoneal doses of 0.5 mg / gram leptin for 6 weeks. Leptin administration induced a significant reduction in tumor size and improved survival in nude mice. Histologically, tumors of leptin-administered mice featured increased inflammatory exudate in interphase areas. Leptin-induced tumor suppression was associated with a significant increase in peripheral natural killer (NK) cell number. Splenocytes from leptin-treated mice featured decreased expression of CIS mRNA. To determine which lymphocyte subset is a prerequisite for the anti tumor effect of leptin, T&B cell deficient (Scid) mice and T,B& NK deficient (Scid-Beige) mice were subcutaneously implanted with Hep3B tumor cells, with and without the daily intraperitoneal administration of 0.5 mg / gram leptin for 6 weeks. SCID mice featured leptin-associated tumor suppression similar to those of nude mice. In contrast, NK-deficient SCID-Beige mice developed larger tumors. To further establish natural killer cell's central role in mediation of leptin's anti-tumor effect, NK cells were incubated in vitro with increasing doses of leptin, demonstrating a dose-dependent increase in cytotoxic activity. Incubation of leptin with hepatoma cell line was found to induce a dose-dependent reduction in hepatoma cell proliferation, suggesting an additive direct anti-tumor effect. Further synergism in inhibition of hepatoma cell proliferation in vitro was achieved following addition of natural killer cells. HCC cells expressed leptin receptor mRNA, while addition of leptin induced increased mRMA expression of STAT2 and SOCS1 on tumor cell lines. Leptin administration induces a significant suppression of human HCC. This effect is mediated by induction of natural killer cell proliferation and activation, and by direct inhibition of tumor growth. Decreased natural killer cell expression of inhibitory CIS protein and over expression of the anti-proliferative STAT2 and SOCS1 proteins in HCC lines may underline both anti cancerous effects of leptin.

The present invention relates to methods for the modulation of immune responses. More particularly, the invention relates to methods and uses of leptin for immune-modulation of the balance between the Th1 / Th2 responses and for the treatment of immune-related disorders. Specifically, the methods of the invention comprise shifting the Th1 / Th2 cell balance towards the proinflammatory state. This modulation of the cell balance may be performed by increasing the activity and / or the expression of leptin in a subject, for instance by raising the amount of leptin. The amount of leptin in a subject may be increased by activating immunoregulatory cells, or by administering an immunomodulatory amount of leptin or a homologue, derivative, or functional fragment of leptin.

A method is provided for controlling an exhaust gas temperature of an engine of a vehicle during interruption of fuel supply to the engine, wherein the engine drives a driveline of the vehicle. The method involves alternating between two or more operational modes, wherein at least one of the operational modes maintains a higher exhaust temperature than the one or more other operational modes.

A double clutch transmission with inputs of two clutches (K1, K2) connected to a drive shaft (wan) and output sides connected to a respective transmission input shaft (w_k1 or w_k2) positioned coaxially to each other, at least two countershafts (w_v1, w_v2) each having toothed idler gearwheels (7, 9, 13, 14, 15, 16, 17, 18), toothed fixed gearwheels (1, 2, 3, 4, 5, 6) are positioned in a fixed manner on the two transmission input shafts (w_k1, w_k2), at least one shift element (N) is provided for connecting two toothed gear wheels with one another so that a plurality of power-shiftable forward gears (1, 2, 3, 4, 5, 6, 7, 8) and a shiftable reverse gear (R1, R2) is provided. A maximum of six gear planes (7-13, 2-14, 9-15, 4-16, 5-17, 6-18) are provided so that at least one power-shiftable winding path gear (G1, R2, O1) is shiftable by the shift element (N).

An electric power tool, in particular an electric hammer, having a drive unit (11) contained in a housing (10), an impact mechanism (12), and a handle (13), including a cam (14) that is driven by the drive unit (11); the impact mechanism (12) has moving parts (15, 16).At least two of the moving parts (15, 16) are able to move inside a separate guide cylinder (17) that is stationary in relation to the moving parts (15, 16) and the cam (14).

The invention relates to a method for covalently bonding an organic metal complex to a polymeric matrix. The method comprises the performance of a first reaction, which comprises a first reactant in the form of an organic metal complex and a second reactant in the form of a polymer, where during the reaction the metal complex is covalently bound to the polymer. According to the invention, the metal complex catalyzes the reaction.

A dilution ratio adjusting apparatus in a beverage dispenser and a method of dilution adjustment calculates driving pulse numbers and pulse frequencies necessary for operating tube pumps discharging concentrated syrup based on dilution ratio information and basic flow rate information for discharging the concentrated syrup to thereby control the operation of the tube pumps, whereby easy and quick change in setting of the beverage dispenser is achieved even when changing of a concentrated syrup to another concentrated syrup with a different dilution ratio.

A double clutch transmission with two clutches whose input sides are connected to a drive shaft and whose output sides are each connected to one of two transmission input shafts arranged coaxially with respect to one another. At least two countershafts are provided on which toothed idler gearwheels are rotatably supported, and toothed fixed gearwheels are positioned on the two transmission input shafts in a rotationally fixed manner such that it is possible to shift at least a plurality of power shiftable forward gears and at least one reverse gear. A maximum of six gear planes are provided so that at least one winding path gear is shiftable when a coupling device of the second countershaft, associated with the output gear, is disengaged.

The invention relates to an expansion valve and a method for controlling an expansion valve, in which the opening and closing movement of the valve-closing element is adjusted as a function of the pressure difference which is present on the high-pressure side in an inlet opening and on the low-pressure side in an outlet opening.

A double clutch transmission with two clutches whose input sides are connected to a drive shaft and whose output sides are each connected to one of two transmission input shafts positioned coaxial with respect to one another. At least two countershafts provided and support toothed idler gearwheels while the two transmission input shafts support toothed fixed gearwheels such that it is possible to shift at least a plurality of power shift forward gears and / or at least one reverse gear. Five gear planes are provided so that at least one winding path gear is shiftable when at least one coupling device, assigned to the output gear, is disengaged.

A method for reducing a driving power of a vehicle drive includes detecting a temperature difference between a temperature of at least one component of the vehicle drive and a temperature threshold value, detecting an instantaneous driving state of the vehicle drive, establishing whether or not the instantaneous driving state allows for a reduction in the driving power of the vehicle drive, and reducing the driving power of the vehicle drive for lowering the temperature of the at least one component in order to increase the temperature difference if the instantaneous driving state allows for the reduced driving power.

The present invention describes the use of leptin for the immune modulation of the Th1 / Th2 response. One aspect of the invention provides for a shift in the Th1 / Th2 cell balance towards pro-inflammatory cytokine producing cells. This shift results from an increase in the levels, expression and / or the activity of leptin. Another aspect of the invention provides for a shift in the Th1 / Th2 cell balance towards anti-inflammatory cytokine producing cells. This shift results from a decrease in the levels, expression and / or the activity of leptin. The shifting of the Th1 / Th2 balance provides a method for the treatment of a variety of diseases and disorders.