5 results about "Th2 response" patented technology

The application belongs to the technical field of biological medicine, and particularly relates to application of CDC37 protein in preparation of Treg cell dysregulation disease treatment product. The application obtains a CDC37 protein with immunoregulatory function and high expression through mass spectrum analysis and bioinformatics analysis on proteins of lung stage child worms of Japanese blood flukes. The amino acid sequence of the CDC37 protein is shown as SEQ ID NO. 1, and the nucleotide sequence of the gene coding the CDC37 protein is shown as SEQ ID NO. 2. Experimental results show that the CDC37 protein can realize the effect of non-hormone-dependent long-acting relief of Treg cell dysregulation diseases by inducing Treg cell expansion, inhibiting Th2 response and reducing airway hyperresponsiveness, and can be used for preparation of Treg cell dysregulation disease treatment product.

The invention provides a preparation process of an anti-allergic health food, and relates to the technical field of health food preparation. The production process of the anti-allergic health-care food comprises the following steps: preparing the following raw materials: herba cistanche, radix astragali, rhizoma polygonati, a bupleurum chinense leaf extract, a dandelion extract, honey and potassium sorbate, wherein the addition ratio of the bupleurum chinense leaf extract to the dandelion extract is 1: 2; cistanche deserticola, astragalus membranaceus and rhizoma polygonati are mixed, excessive water is added for soaking, reflux extraction and filtration are performed, filtrate is combined, and an extracting solution is obtained. By adding the bupleurum chinense leaf extract and the dandelion extract into an extracting solution of traditional Chinese medicinal materials such as astragalus membranaceus, the ratio of IgG1 / IgG2a can be effectively reduced, namely Th1 type immune response is relatively enhanced, Th2 type response is relatively weakened, allergen-specific IgE antibodies generated by B cells are correspondingly reduced, degranulation reaction and release of inflammatory mediators such as histamine are relieved, and the anti-inflammatory effect is achieved. The anaphylactic reaction is effectively relieved.

The present invention discloses a nutritional composition comprising a combination of non-digestible oligosaccharides and a product obtained by incubation of an aqueous substrate with Bifidobacterium and optionally a product obtained by incubation of an aqueous substrate with Streptococcus thermophilus. The combination synergistically improves the immune system by stimulating Th1 response, and / or attenuating Th2 response, improving immunization response, improving resistance to infection and / or reducing allergic reactions.

The invention belongs to the technical field of biological medicine, and particularly relates to application of CDC37 protein in preparation of a product for treating Treg cell dysfunctional diseases, the CDC37 protein with an immune regulation function and high expression is obtained by performing mass spectrometry and biosignal analysis on protein of schistosoma japonicum lung-stage juvenile worms, the amino acid sequence of the CDC37 protein is shown as SEQ ID NO.1, and the CDC37 protein can be applied to preparation of a product for treating Treg cell dysfunctional diseases. The nucleotide sequence of the gene for coding the CDC37 protein is as shown in SEQ ID NO. 2. Experimental results show that CDC37 protein can achieve the effect of non-hormone-dependent long-acting alleviation of the Treg cell dysregulated diseases by inducing Treg cell amplification, inhibiting Th2 reaction and reducing airway hyperreactivity, and can be used for preparing a product for treating the Treg cell dysregulated diseases.

The application belongs to the technical field of vaccines, and particularly relates to a subunit vaccine for preventing and controlling porcine epidemic diarrhea of piglets. The subunit vaccine comprises an antigen and an adjuvant, the antigen is PEDV S protein, the adjuvant is O / W type nanoemulsion adjuvant TMC-NE based on quaternary ammonium chitosan, the TMC-NE is prepared from an oil phase, mixed surfactant and an aqueous phase as raw materials, and the mass ratio of the oil phase, the mixed surfactant and the aqueous phase is 15:35:50. The subunit vaccine for preventing and controlling porcine epidemic diarrhea of piglets effectively improves the immunogenicity of the antigen, induces the body to produce a more balanced Th1 / Th2 response, stimulates the body to produce effective cellular immunity and humoral immunity, and adjusts adaptive immune response by loading PEDV S protein on quaternary ammonium chitosan nanoemulsion to immunize piglets. It is also indicated that the quaternary ammonium chitosan nanoemulsion has application potential as an immune adjuvant, and the prepared PEDV S subunit vaccine is expected to become a new vaccine for effectively preventing and controlling porcine epidemic diarrhea.