861 results about "Immunopotentiator" patented technology

The invention relates to a general-purpose composite Chinese herbal medicine immune enhancer for freshwater cultured fish, which is made of raw materials with the following weight ratios, based on the amount added per ton of feed: rhubarb 800-2000g; Sanqi 350-1000g; water Silybum 1200-2500g; Cassia 600-800g; Astragalus 600-2000g; Scutellaria baicalensis 500-900g; 500-1500g; Garlic 1000-2000g. After many tests in the laboratory, it has been proved that the general-purpose compound Chinese herbal medicine immune enhancer for freshwater aquaculture fish can improve the survival rate of a variety of freshwater aquaculture fish in the process of attacking viruses; The long-term breeding experiment of farmed fish feed proves that the general-purpose compound Chinese herbal medicine immune enhancer for freshwater farmed fish can effectively reduce the incidence of a variety of high-density farmed freshwater fish and improve the survival of the breed; the additive is safe, efficient, and has no side effects for long-term use. The breeding objects have strong vitality, rapid growth, bright body color, high feed conversion rate, and good breeding benefits.

The invention discloses an anti-stress health compound feed for jewfish. The feed consists of an animal protein source, a plant protein source, a fat source raw material, a sugar source raw material, composite vitamin, composite mineral salt, hepatinica, a Chinese herbal medicine compound preparation, probiotic powder, a composite immunopotentiator, antimicrobial peptide, an acidifying agent and a premixed compound additive, wherein the animal protein source comprises one or more of fish meal, euphausiid meal and chicken meat meal; the plant protein source comprises one or more of seaweed meal, fermented soybean meal, soy protein concentrate and corn protein powder; the fat source comprises one or more of soybean oil, fish oil and phosphatide oil. The feed disclosed by the invention has the characteristics of being rapid in growth, low in food coefficient, good in stability in water, rapid to eat, convenient to use, low in feeding cost, resistant to stress, healthy and the like.

The invention provides a compound Chinese herbal medicine immunopotentiator for fish, containing by weight of: 40-50% of astragalus, 10-20% of angelica, 15-20% of glycyrrhiza, 5-10% of hawthorn, 5-12% of honeysuckle and 5-12% of isatis. Advantages of the invention is that: (1) the immunopotentiator of the invention has no adverse effect on palatability of feedstuff, (2) body immunity of culture fishes can be substantially enhanced, and immunoprotection rate to fresh water aquiculture fishes and marine culture fishes reaches to 65-71%, and (3) growth of pathogenic bacteria like escherichia coli in intestinal tract of culture fishes can be substantially restrained, growth of fish can be promoted rapidly, and weighting rate and disease resistance of culture fishes can be raised. The immunopotentiator is suitable for various of culture fishes, has a broad future, and is easy for industrialization.

The invention discloses a nanometer particle adjuvant, a preparation method thereof, and the application thereof in the preparation of inactivated vaccines. According to the invention, a novel nanometer particle adjuvant is obtained through preparation by the emulsion preparation and the nanometer treatment following the dissolving of different immunopotentiator and surfactant in water and oil respectively. The adjuvant provided by the invention not only can remarkably improve the humoral immune response and the cellular immune response of various bacterial and viral inactivated vaccines, butalso has unique advantages in the preparation process, the stability, the immunity duration and the side reaction of vaccines.

The invention relates to a Chinese herbal medicine biological feed additive for livestock and a preparation method of the Chinese herbal medicine biological feed additive. The prepared Chinese herbal medicine biological feed additive for the livestock comprises the following raw materials in percentage by mass: 20% of probiotics, 10% of an enzyme preparation, 50% of traditional Chinese medicines, 10% of amino acids, 4% of vitamins, 1% of micro elements, 1% of an immunopotentiator, 1% of bacitracin and 3% of glucose. The preparation method comprises the following steps: firstly carrying out expanding culture to revive the probiotics, fermenting the probiotics for 2 days so as to obtain probiotics fermentation liquor; placing the traditional Chinese medicines into the probiotics fermentation liquor for fermentation; and finally mixing the dried fermentation products with other raw materials so as to obtain the Chinese herbal medicine biological feed additive for the livestock. The prepared Chinese herbal medicine biological feed additive for the livestock disclosed by the invention has the advantages of improving the immunity, increasing the utilization rate of the feed, improving environment and the like.

The invention discloses an oil-in-water type vaccine adjuvant as well as a preparation method and application thereof. The oil-in-water type nano-emulsion vaccine adjuvant comprises the following components in percentage by mass: 0.1-10 percent of oil phase, 0.1-10 percent of emulsifier, 0.1-3 percent of stabilizer, 0.1-3 percent of complexing agent and 0.01-10 percent of immunopotentiator. The preparation method comprises the following steps: (1) uniformly dispersing the immunopotentiator, the stabilizer and the complexing agent in water, thereby obtaining an aqueous phase; (2) mixing an oil phase and an emulsifier, thereby obtaining an oil phase; (3) slowly adding the oil phase into the aqueous phase, and continuously stirring, thereby forming a stable emulsion; (4) regulating the pH value of the emulsion, and fixing the volume to obtain a primary emulsion; and (5) performing high-speed shearing and high-pressure homogenizing on the primary emulsion. The vaccine adjuvant provided by the invention is simple in preparation, convenient to use and small in side reactions, is used for diluting vaccines, particularly swine fever live vaccines and is high in stability and good in immune effect.

The invention discloses non-resistant dust-free piglet creep formula feed and a preparation method thereof. The feed is prepared from the following components: corns, fermented corns, soybean meal, fermented soybean meal, expanded soybean flour, expanded corn flour, imported fish meal, spray-dried plasma proteins, dried porcine solubles, powdered whey, soybean oil, sucrose, molasses, sodium glutamate, a feeding promoting agent, Yibao phospholipid, yeast autolysate, an acidifying agent, stone powder, calcium hydrogen phosphate, table salt, 98.5 percent of lysine, 98.5 percent of threonine, 10 percent of tryptophan, special compound enzyme for early-weaned piglets, phytase enzyme, a micro-ecological preparation, a Chinese herbal medicine heath preserver, antibacterial peptide, immunopotentiator, 50 percent of choline chloride and a premix. The preparation method comprises the following steps: firstly, separately preparing granulated feed products and powdery feed products; and then mixing the granulated feed products with the powdery feed products to obtain the non-resistant dust-free piglet creep formula feed. According to the feed disclosed by the invention, antibiotics are not added, a formula is scientific, the dust of the product is low, the palatability and the immunity are improved, and a diarrhea ratio of piglets is reduced.

The present invention discloses a special penaeus orientalis functional biological feed in the thickness marking period and the functional biological feed consists of the following components: import fish meal, shrimp meal, fermented peanut meal, fermented soybean meal, yeast lysates, cuttlefish powder, high gluten flour, calcium dihydrogen phosphate, soybean lecithin, fish oil, vitamin-mineral premixes, probiotics and functional additives; wherein the probiotics consist of Bacillus subtilis subsp., Candida utilis yeast and Bifidobacterium longum; the functional additives are made of natural astaxanthin, linolenic acid, fermented chlorella and fermented spirulina. The functional biological feed aims at the physical characteristics of high density, high nutrition and fast growth of penaeus orientalis seedlings in the thickness marking period, uses high-quality animal protein, contains high levels of unsaturated fatty acids and bio-fermentation raw materials, is rich in lecithin, has a reasonable balance ratio of calcium and phosphorus, and fortified vitamin nutrition, adds immunoenhancers, living beneficial bacteria and digestive enzymes, promotes the rapid growth, enhances disease resistance and improves survival rate of penaeus orientalis seedlings which have strong body constitution and tidy specifications, and lay a solid foundation for subsequent successful breeding.

Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminium salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.

Compound Chinese medicinal herb immunopotentiator for cobia is characterized by comprising the following components by weight: 10 to 15 percent of radix astragali, 10 to 15 percent of rhizoma coptidis, 10 to 15 percent of radix bupleuri, 8 to 12 percent of honeysuckle, 8 to 12 percent of rhubarb, 8 to 12 percent of eucommia bark leaf powder, 6 to 10 percent of liquorice, 6 to 10 percent of radix codonopsitis, 6 to 10 percent of angelica and 6 to 10 percent of creat. The invention has the advantages that the compound Chinese medicinal herb immunopotentiator can be used as feed additive in cobia feed and is added in the cobia feed by only 0.1 to 0.2 percent, can obviously increase the organism immunity and improve the survival rate of the cobia, has no harmful effect to the palatability of feed, and has stable raw material sources, low cost and simple production technology.

The invention provides a nibea albiflora richardson larvae and juvenile microcapsule feed which is prepared from white fish meal, euphausiid meal, squid meal, fish protein hydrolysate, feed yeast, alpha-starch, soybean lecithin, papain, fish oil, composite vitamin, composite mineral substance, binder, immunopotentiator, phagostimulant and the like. By adopting the innovated prescription and processing process, the microcapsule feed can fulfill the requirement for nutrition of larvae and juvenile growth, has the advantages of comprehensive nutrition, good palatability, high water stability, low cost and the like, can be produced in batches, is convenient for storing, transporting and feeding, is suitable for industrial breeding production, and adopts a corresponding feeding method, so that the survival rate of nibea albiflora richardson is greatly improved, the shape of the nibea albiflora richardson is increase. The nibea albiflora richardson larvae and juvenile microcapsule feed is suitable for large-scale popularization and application.

Influenza vaccines containing insoluble particulate adjuvants have been found to elicit an IgG response that is primarily a TH2 response (IgG1). This response can be shifted towards a TH1 response (IgG2a) by including immunopotentiators in the compositions. Thus the invention provides an immunogenic composition comprising: (i) an influenza virus antigen; (ii) an insoluble particulate adjuvant; and (iii) a immunopotentiator.

The invention provides a method for preparing triple vaccine for preventing porcine transmissible gastroenteritis, porcine epidemic diarrhea and porcine rotavirus. The method comprises the following steps: inoculating a host-cell line with a 90 percent grown monostratum against a porcine transmissible gastroenteritis virus, a porcine epidemic diarrhea virus and a porcine rotavirus respectively, and adding a cell maintenance media into the host-cell lines respectively to be cultured at 37 DEG C; after cytopathic effect reaches over 75 percent, collecting viruses to be stored at 20 DEG C below zero for standby; mixing the viruses according to 10 TCID50 in 1:1:1, and simultaneously adding Freund's complete adjuvant and immunopotentiator into the mixture to inactivate the mixture by formaldehyde at 37 DEG C for 24 hours; and adding an oil adjuvant into the mixture to prepare a vaccine of water-oil-water preparation. The method can be used for preparing the triple vaccine for preventing the porcine transmissible gastroenteritis, the porcine epidemic diarrhea and the porcine rotavirus so as to solve the problem that the diseases do not have an effective medicine to treat currently.

The invention discloses a water-in-oil-in-water adjuvant vaccine and a preparation method thereof. The adjuvant vaccine is composed of an internal water phase, a middle oil phase used for cladding the internal water phase, and an external water phase for cladding the middle oil phase. The external water phase comprises: a composite surfactant, a hydrophilic surfactant and mormal saline. The middle oil phase consists of: a lipophilic surfactant, a stabilizer and mineral oil. The internal water phase comprises: an immunopotentiator solution, the hydrophilic surfactant, and an inactivated antigen solution. The W/O/W (water-in-oil-in-water) type adjuvant vaccine provided in the invention can induce an immunoreaction earlier than traditional W/O (water-in-oil) type adjuvant vaccines, and can make experimental animals obtain earlier protective antibodies. The vaccine has good absorption, and causes a small inflammatory response at an inoculation site. The adjuvant vaccine disclosed in the invention has better stability than existing W/O/W type vaccines, and the antibody generation speed is fast.

The invention discloses a fermented Chinese herbal immunopotentiator used for snakeheads. With the efficacy of prevention, health care, treatment and immunoregulation, the Chinese herbal immunopotentiator is an ideal, green, environmental friendly, safe and novel feed additive for substituting antibiotic drugs. The fermented Chinese herbal feed additive is prepared by subjecting compound Chinese herbal medicines to a process of ''ultrasonic wave assisted extraction of Chinese herbal medicines and multi-strain two-step fermentation'', has the advantages of both Chinese herbal medicines and probiotics, can efficiently condition the intestinal health of snakeheads, treat both symptoms and root causes, consolidate the basis and foster vitality, maintain intestinal microecological balance and an optimal immune state, improves the digestibility of nutrients, improves the body immunity of snakeheads, improves farming profits, and reduces farming risk. The Chinese herbal immunopotentiator can be used for replacing antibiotics, has no adverse effect on snakeheads, is safe to use, and is free of drug residue, drug resistance and other problems, thus having broad market prospects.

The invention relates to a yeast composition and a feed. The yeast composition of the invention comprises: A, a yeast hydrolysate; B, yeast cell wall polysaccharide; and C, bacillus; in addition, the yeast composition of the invention further comprises: D, an active yeast; and E, an anti caking additive. The yeast composition of the invention is mainly applied to powdery or granular feed, combines multi-functions of a micro-ecological preparation, a phagostimulant, an immunopotentiator and the like, and obviously improves the effectiveness and stability.

The invention provides a compound feed of pelteobagrus fulvidraco food fish and a preparation method thereof. The compound feed comprises the following components in percentage by weight: 20-45% of fish meal, 4-10% of meat and bone meal, 15-25% of flour, 4-10% of corn, 10-25% of soy bean meal, 4-10% of rapeseed meal, 1-4% of fish oil, 10-25% of corn gluten meal, 1.0% of multivitamins, 1.0% of multiminerals, 0.1% of immunopotentiator, 0.2% of liver protecting agent, 0.2-0.4% of choline and 1-2% of calcium biphosphate. The compound feed has high quality grinding particle size, mixing uniformity, feed shaping property, water resistance and other characteristics. The pelteobagrus fulvidraco food fish fed with the compound feed has body color close to the natural body color, and the compound feed can improve the anti-virus capability of the pelteobagrus fulvidraco, shorten the breeding cycle, reduce the breeding cost, reduce the sources of the diseases and water body pollution and has obvious economic and environmental benefits.

The invention discloses a method for the formation of liposomes by using high shear mixing of aqueous solution of lipid powder; the lipid powder can be produced by any known technique. Components of the liposomes include but are not limited to cationic lipids, immunostimulatory/immunopotentiators and macromolecules as components for the liposome formation. The disclosed method describes the formulation of stable liposomes solitary or complexing high concentrations of macromolecules such as proteins, DNA and RNA having opposite charge of the liposomes by high shear mixing where aggregation is avoided due to the formulation method.

The invention discloses environment-friendly sea cucumber micelle feeds and a preparation method thereof, belonging to the technical field of feeds. The invention is characterized in that the feed comprises the following raw materials by percent: 20-35% of seaweed meal, 5-15% of fish meal, 8-30% of soybean meal, 10-25% of sea mud, 0-10% of cornmeal, 1-2.5% of shell meal, 1% of compound vitamins and minerals and plant immunopotentiators and microbial preparations added according to the circumstances. The preparation method is characterized by pretreating the feed raw materials, drying and coarsely grinding the raw materials until the grain size is 40-60 meshes, then adding proper amount of additives, obtaining the ultramicro powder raw materials with grain size of 600-800 meshes by the micro shear-additive technology, then adding water according to the weight ratio of 1:1, forming the mixture by extrusion after full and uniform mixing, drying and then progressively grinding the formed materials to obtain the micelle feeds with different grain sizes. The feeds solve the problem that the existing sea cucumber feeds are easy to lose nutrients, have low feed coefficient, pollute the water quality and trigger diseases, and have low production cost and simple process and are easy to be produced in scale.

The invention relates to an artificial particle feed for juvenile turbot. The artificial particle feed is characterized by being prepared from whitefish powder, euphausiid powder, scallop powder, beer yeast, starch, cod liver oil, yolk powder, whey powder, L-alanyl-L-glutamine, choline chloride, soybean lecithin, schizochytrium limacinum powder, haematococcus pluvialis powder, compound vitamins, compound mineral substances, Chinese herbal medicines and sodium alginate. As the various raw materials are added into the feed, the comprehensiveness of nutrition is guaranteed. An immunopotentiator is added into the feed, so that the non-specificity immunity of fish bodies is enhanced. The feed is green and pollution-free. The schizochytrium limacinum powder and the haematococcus pluvialis powder are added into the feed, and the content of vitamin E is improved, so that the whitening rate of the juvenile fish is effectively reduced. The Chinese herbal medicine components are added, so that the immunity of the juvenile fish can be improved and parasite diseases in a juvenile fish growing phase are prevented from happening.

The invention relates to a whole Luchuan pig feed capable of improving Luchuan pig feeding rewards. The whole Luchuan pig feed aims at overcoming the defects of short and small bodies, low growth speed and low feeding rewards of Luchuan pigs and can promote the growth and development and improve the immunity and digestion and absorption functions as well as infection resistance by improving nutritional components of the feed. The feed comprises the following raw materials: bean dregs, corn flour, potato powder, wheat middling, wheat flour, sorghum flour, rice flour, wheat bran, paddy meal, rice bran, calcium hydrophosphate, table salt, lysine and a premix, wherein the premix comprises living lactic acid bacteria, yeast autolysate, chelate metal trace elements, active calcium and phosphorus, fermentation type traditional Chinese medicine, complex vitamins, an immunopotentiator, mannan oligosaccharide and xylooligosaccharide. The cost unit price of the feed is about half of that of a traditional complete feed on the market, so that the breeding cost of pigs is lowered; the pigs can be slaughtered 15 days in advance, pig houses are free of odor, the pigs are healthy, and are low in morbidity, high in survival rate and good in meat quality and flavor, and the medical expense is reduced.

The invention provides a river crab used immunopotentiator and preparation method, wherein the immunopotentiator is prepared from vitamin C, E, carotene-beta, bread yeast cell wall containing 30% beta-glucan, mannose, algin, licorice root, phosphatide and rice bran through solid raw material disintegrating, sieving, solid raw material mixing, phosphatide miscible liquid preparation, phosphatide miscible liquid spraying and drying.

The invention relates to a golden pompano immune promoting compound feed and a preparation method thereof. The feed comprises fish meal, flour, shrimp pulp, bean meal, corn protein powder, fish oil, meat meal, a plurality of vitamins, a plurality of mineral substances, immunopotentiator, bilineurine and dibastic sodium phosphate; and the preparation method comprises the following steps: batching, primary cleaning, primary mixing, iron removing, crushing, secondary mixing, conditioning, puffing, drying, grease spraying, cooling and packaging. The formula of the feed is scientific and reasonable, and the high-efficiency pollution-free immunopotentiator is added into the feed, which causes the feed to have high-quality crushing particle size, mixing uniformity, feed formability, water resistance, etc.; furthermore, the compound feed has the advantages of improving the absorption and utilization rates, satisfying the nutrition requirements of the golden pompano, improving disease resistance of the fish, and promoting the quick and sound growth of the fish; thus greatly shortening the breeding cycle, reducing the breeding cost and reducing the pollution to water body; and the preparation method is scientific and reasonable and has obvious economic benefit and environmental benefit.

Compound Chinese medicinal herb immunopotentiator for rudd is prepared from the components by weight: 10 to 20 percent of radix astragali, 10 to 20 percent of honeysuckle, 10 to 15 percent of rhubarb, 10 to 15 percent of eucommia bark leaf powder, 10 to 15 percent of liquorice, 10 to 15 percent of hawthorn, 5 to 10 percent of Rhizoma Atractylodis Macrocephalae, and 5 to 10 percent of safflower. The invention has the following advantages that the compound Chinese medicinal herb immunopotentiator can be used as feed additive in rudd compound feed, and is added in to the rudd compound feed by only 0.1 to 0.2 percent, can remarkably increase the organism immunity and improve the survival rate of rudd, can completely replace antibiotics, has no adverse effect and no residue to the palatability of feed, and has a stable raw material resources, low cost and simple production technology.

An application of indole-2.3-bione in preparing the antiviral medicine for HIV, influenza virus, hemorrhagic virus and herpes simplex virus and the immunopotentiator is disclosed.