49 results about "Immunopotentiator" patented technology

The invention discloses an immunogenic composition containing an adjuvant as well as a preparation method and application of the immunogenic composition. The immunogenic composition comprises self-assembled gE virus-like nanoparticles, an immunopotentiator, namely, saponin QS-21, and a neutral liposome, the self-assembled gE virus-like nanoparticles are formed by polymerizing and assembling monomers; the monomers include VZV gE, a linker peptide (SGS), and a VZV gI polypeptide containing a Th epitope. The immunogenic composition can be applied to varicella-zoster virus vaccines, and solves the technical problems of weak gE immunogenicity and serious vaccine side reaction in vaccines prepared in the prior art. The immunogenicity of the vaccine is equivalent to that of the Xinanlii, and the use of an immunopotentiator in the vaccine can be reduced, so that the clinical side reaction of the vaccine is lower; in addition, the vaccine can induce a gI specific antibody and gI specific CMI reaction, and the effectiveness of the vaccine can be further improved. In short, the immunogenic composition has good clinical application potential.

The invention discloses an immunogenic composition containing a composite adjuvant as well as a preparation method and application of the immunogenic composition. The immunogenic composition comprises a gE-gI fusion protein, an immunopotentiator, namely, saponin QS-21, and a neutral liposome, the gE-gI fusion protein comprises a VZV gE, a connecting peptide and a VZV gI. The immunogenic composition provided by the invention only contains one immunopotentiator, can be applied to VZV vaccines, and solves the problems of relatively weak gE immunogenicity and relatively large clinical side reaction of the vaccines prepared in the prior art. The immunogenicity of the vaccine is equivalent to that of the Xinanlii, but the vaccine contains fewer immunopotentiators and has lower clinical side effects; in addition, the vaccine can also induce a gI specific antibody and gI specific CMI reaction, which is beneficial to further improvement of the effectiveness of the vaccine. In short, the immunogenic composition has good clinical application potential.

The present invention relates to a composition for enhancing immunity, containing, as an active ingredient, a polysaccharide enzyme-treated product derived from a mixed extract of Angelica gigas, Cnidium officinale, and Paeonia lactiflora, or a novel purified polysaccharide fraction thereof. The composition for enhancing immunity according to the present invention, comprising the polysaccharide enzyme-treated product of the mixed extract of Angelica gigas, Cnidium officinale, and Paeonia lactiflora or the novel purified polysaccharide fraction thereof, is composed of specific types and contents of sugars and significantly increases the activity of macrophages, splenocytes, and NK cells upon application thereto, thereby being applicable as an immunopotentiator or a composition for enhancing immunity.

The invention relates to the technical field of biological medicine, in particular to an immune synergist, an enhanced NK cell preparation, a preparation method and application. The immune synergist is hirudin, and the concentration of the hirudin is 10-40 [mu] g / ml. The enhanced NK cell preparation is prepared by the preparation method. According to the preparation method, the enhanced NK cell preparation is obtained after NK cells which are amplified in vitro for 14 days are pretreated by adopting the immune synergist. The application comprises an application of the immune synergist in up-regulation of expression of NK cell granzyme B and an application of the immune synergist in preparation of an NK cell preparation for inhibiting breast cancer cell activity. The expression level of granzyme B of the NK cells can be safely and economically improved, and the in-vitro killing activity of the NK cells to breast cancer cells is remarkably enhanced.

The invention relates to the technical field of immunization. The invention discloses parabacteroides dieldrii and parabacteroides goldsteinii, an application of the parabacteroides dieldrii and / or the parabacteroides goldsteinii in preparation of an immunopotentiator of a vaccine, and the immunopotentiator of the vaccine, and particularly discloses the parabacteroides dieldrii and the parabacteroides goldsteinii, the application of the parabacteroides dieldrii and / or the parabacteroides goldsteinii in preparation of the immunopotentiator of the vaccine. The parabacteroides dieldrii and / or the parabacteroides gold can be used as an immunopotentiator, can activate immunity, enhance antibody titer and shorten antibody generation reaction time, and can remarkably promote proliferation of B cells, plasma cells and memory B cell subgroups in a hair growth center.

The invention discloses a gE fusion protein containing a gH Th epitope and a preparation method and application thereof, and relates to the technical field of biomedicine, the fusion protein comprises a varicella-zoster virus (VZV) glycoprotein E extracellular domain (gE) and a Th epitope-containing VZV glycoprotein H extracellular domain (gH) polypeptide. The gE fusion protein can be applied to VZV vaccines, and solves the technical problems of weak immunogenicity of gE antigens and serious side reaction of vaccines in vaccines prepared in the prior art. Compared with the Xinanlietaine, the vaccine taking the gE fusion protein as the antigen has the advantages that the variety and dosage of immunopotentiators are less, the immunogenicity is better, and the clinical side reaction is lower; besides, the gE fusion protein vaccine not only can induce a gE specific CMI reaction, but also can induce a gH specific CMI reaction, so that the effectiveness of the vaccine is further improved. In short, the gE fusion protein has good clinical application potential.

The invention discloses an immunogenic composition containing gE virus-like nanoparticles as well as a preparation method and application of the immunogenic composition. The immunogenic composition comprises gE virus-like nanoparticles, an immunopotentiator, namely, saponin QS-21, and a neutral liposome, the gE virus-like nanoparticles comprise VZV gE, a linker peptide (SGS) and a VZV gI polypeptide containing a Th epitope. The immunogenic composition provided by the invention can be applied to VZV vaccines, and solves the technical problems of weak gE immunogenicity and serious vaccine side reaction in vaccines prepared in the prior art. The immunogenicity of the vaccine is better than that of Xinanliei, the use of an immunopotentiator is reduced, and the clinical side reaction is lower. In addition, the vaccine can also induce an obvious gI specific antibody, which is beneficial for further improving the effectiveness of the vaccine. In short, the immunogenic composition provided by the invention has good clinical application potential.

To provide an intestinal disorder controlling agent, an antiallergic agent, an immunopotentiator and an intestinal adhesion improver of lactic acid bacteria, safely ingestible, inexpensively available and excellent in intestinal adhesion improving action of lactic acid bacteria.SOLUTION: The agent of the present invention contains a flower extract. The flower is a flower of Lythraceae, Asteraceae, Fabaceae, Rosaceae or Iridaceae, and is particularly preferably at least one selected from the group consisting of safflower, pomegranate, kudzu, cherry, chrysanthemum, saffron, peach and rose.SELECTED DRAWING: Figure 1

The present invention relates to a composition for enhancing immunity, comprising, as an active ingredient, an enzyme-treated product of polysaccharides derived from a mixed extract of Angelica gigas, Cnidium officinale, and Paeonia lactiflora, or a novel purified fraction thereof. According to the present invention, the composition for enhancing immunity, comprising, as an active ingredient, an enzyme-treated product of polysaccharides from a mixed extract of Angelica gigas, Cnidium officinale, and Paeonia lactiflora, or a novel purified fraction thereof, comprises specific types and contents of sugars. Thus, when macrophages, splenocytes, and NK cells are treated with the composition, the composition significantly increases the activities thereof, and therefore can be applied as an immunostimulant or a food composition for enhancing immunity.

The invention discloses an immunogenic composition containing nanoparticles as well as a preparation method and application of the immunogenic composition. The immunogenic composition is prepared from self-assembled gE nano-particles, saponin QS-21 and a neutral liposome, wherein the self-assembled gE nano-particles are self-assembled gE nano-particles; the self-assembled gE nanoparticles are formed by polymerizing and assembling monomers; the monomer comprises a VZV gE, a connecting peptide 1 (SGS), a VZV gI polypeptide containing a Th epitope, a connecting peptide 2 (GSGSG) and an influenza virus hemagglutinin Th epitope. The immunogenic composition can be applied to VZV vaccines, and solves the technical problems of weak gE immunogenicity and serious vaccine side reaction in vaccines prepared in the prior art. The immunogenicity of the vaccine is higher than that of Xinanliei, the use of an immunopotentiator can be reduced, and the clinical side reaction is lower; the vaccine can also induce an obvious gI specific CMI reaction, which is beneficial to further improvement of the effectiveness of the vaccine. The immunogenic composition has good clinical application potential.

The invention belongs to the technical field of molecular biology, and relates to a truncated fish peptidoglycan recognition protein and application thereof. The amino acid sequence of the truncated fish peptidoglycan recognition protein is as shown in SEQ ID NO. 1 in the table. Compared with a natural peptidoglycan recognition protein, the truncated fish peptidoglycan recognition protein provided by the invention has higher expression efficiency and higher yield in a prokaryotic expression system; in addition, the binding capacity with main components, namely peptidoglycan (PGN) and lipopolysaccharide (LPS), of cell walls of gram-positive bacteria and gram-negative bacteria is higher; the bacteriostasis and agglutination capacities on gram-positive bacteria and gram-negative bacteria are obviously improved. The characteristics show that the truncated fish peptidoglycan recognition protein has the development potential as an aquatic product immunopotentiator, and important support is provided for subsequent application research.

The invention discloses an immunogenic composition as well as a preparation method and application thereof. The immunogenic composition comprises self-assembled gE nanoparticles, an immunopotentiator, namely, saponin QS-21, and a neutral liposome, the self-assembled gE nanoparticles are formed by polymerizing and assembling a plurality of monomers, and the monomers comprise VZV gE, a linker peptide (SGS) and VZV gI polypeptide containing Th epitopes. The immunogenic composition can be applied to VZV vaccines, and solves the technical problems of weak gE immunogenicity and serious vaccine side reaction in vaccines prepared in the prior art. The immunogenicity of the vaccine is equivalent to that of Xinanliei, and the use (variety and dosage) of an immunopotentiator can be reduced, so that the clinical side reaction of the vaccine is lower; in addition, the vaccine can induce a high-level gI specific CMI reaction, which is beneficial to further improvement of the effectiveness of the vaccine. In short, the immunogenic composition has good clinical application potential.

The invention discloses gE virus-like nanoparticles as well as a preparation method and application thereof. The gE virus-like nanoparticles are formed by polymerizing a plurality of monomers; the monomers include VZV gE and VZV gI polypeptides. The immunogenicity of the gE virus-like nanoparticle is better than that of gE, and the preparation method is simple; the gE antigen can be applied to VZV vaccines, and the technical problems that in vaccines prepared in the prior art, the immunogenicity of the gE antigen is poor, and side reactions of the vaccines are serious are solved. Compared with the Xinanlietaine, the vaccine taking the gE virus-like nanoparticles as the antigen has the advantages that the variety and dosage of the immunopotentiator are less, the immunogenicity is better, and the clinical side reaction is lower; besides, the gE virus-like nanoparticle vaccine not only can induce a gE specific antibody reaction, but also can induce a gI specific antibody reaction, so that the effectiveness of the vaccine is further improved. The gE virus-like nanoparticles have good clinical application potential.

The invention discloses a compound immunopotentiator as well as a preparation method and application thereof, and belongs to the technical field of aquaculture. The compound immunopotentiator contains a gallnut water extract, a gallnut alcohol extract, an astragalus membranaceus water extract, an astragalus membranaceus alcohol extract, a rhodiola rosea water extract, a rhodiola rosea alcohol extract and chlorogenic acid. The compound immunopotentiator provided by the invention can significantly improve the resistance of aquaculture animals to pathogen infection, is free of environmental pollution and drug resistance risks, and has good safety and effectiveness. Experiments show that for aquatic products infected with nervous necrosis viruses, the positive rate of the nervous necrosis viruses can be obviously reduced by adding the compound immunopotentiator into feed of the aquatic products; for aquatic products treated by mixed infection of nervous necrosis virus and vibrio harveyi, the death rate of the aquatic products can be obviously reduced by adding the compound immunopotentiator into feed of the aquatic products, so that the compound immunopotentiator disclosed by the invention has a good immunoprotection effect when coping with the mixed infection of virus and bacteria.

The invention discloses an immunogenic composition containing gE nanoparticles as well as a preparation method and application of the immunogenic composition, and relates to the technical field of biomedicine. The immunogenic composition is prepared from self-assembled gE nano-particles, saponin QS-21 and a neutral liposome, wherein the self-assembled gE nano-particles are self-assembled gE nano-particles; the self-assembled gE nanoparticles are formed by self-assembling monomers; the monomers comprise VZVgE, a connecting peptide and a VZV gI polypeptide containing a Th epitope. The immunogenic composition can be applied to VZV vaccines, and solves the technical problems of weak gE immunogenicity and serious vaccine side reaction in vaccines prepared in the prior art. The immunogenicity of the VZV vaccine is higher than that of Xinanliei, the dosage of an immunopotentiator is less, and the clinical side reaction of the vaccine is lower; in addition, the vaccine can also induce a gI specific CMI reaction, which is beneficial for further improving the effectiveness of the VZV vaccine. In short, the immunogenic composition has good clinical application potential.

The present invention relates to use of β-glucan extracts in the immunopotentiation of an avian animal. Specifically, the present invention provides a kit, wherein the kit comprises (1) an immunopotentiator used for immunopotentiation of an avian animal, wherein the immunopotentiator comprises a β-glucan extract which is extracted from Saccharomyces cerevisiae cell wall; and (2) a virus vaccine. The present invention also provides use of a β-glucan extract which is extracted from Saccharomyces cerevisiae cell wall, in the preparation of a kit used for immunopotentiation of an avian animal and immunopotentiator. The present invention uses a β-glucan extract, which is extracted from Saccharomyces cerevisiae cell wall, for immunopotentiation of an avian animal, which can enhance lymphocyte proliferation responses and T cell responses of vaccinated animals; decrease the viral load; reduce the morbidity or mortality; produce antibodies in advance; and increase antibody production; and / or restrict the spread of the virus.

The invention relates to the technical field of immune preparations, in particular to application of Forskolin or pharmaceutically acceptable salt thereof in preparation of a vaccine immunopotentiator. Aiming at the defects of vaccine immunomodulators in the prior art, the invention provides a novel method for enhancing the immune effect of a vaccine by using a natural plant extract Forskolin (as an adenylate cyclase activator), the Forskolin can promote high expression of CXCR4 by plasma cells to obviously enhance the homing ability, the residence ability and the service life of the plasma cells, so that the immune effect of the vaccine is enhanced. Therefore, the long-term immune response of the antibody is improved. The Forskolin directly targets the effector cytoplasm cells immunized by the vaccine, so that the potential safety hazard of the traditional technology is avoided, and meanwhile, more lasting and stable immune protection is provided.

The invention relates to the technical field of immunologic adjuvants, in particular to a preparation method of an inactivated vaccine containing the compound immunopotentiator, which comprises the following steps: mixing the compound immunopotentiator with an inactivated antigen and Tween 80 to prepare a water phase solution; mixing white oil, span 85 and aluminum stearate to obtain an oil phase solution; and shearing and emulsifying the oil-phase solution and the water-phase solution to obtain the inactivated vaccine. According to the preparation and application of the avian influenza triple inactivated vaccine containing the compound immunopotentiator, the specific compound immunopotentiator is prepared from all components of polyinosinic-polycytidylic acid, 2 ', 3'-cyclic guanosine monophosphate, 2 ', 3'-cyclic guanosine monophosphate and QS, the dissolution rate of insoluble drugs is increased, and the bioavailability of the drugs is improved; therefore, the retention time of the antigen in the body is prolonged to achieve the purpose of slow release, the continuous activation effect on the immune system is maintained, the cellular immune and humoral immune functions are further improved, and the antibody level and immune effect of the immunized body are further enhanced.

A phytochemical and nutraceutical composition and method for protection against a wide spectrum of viral and bacterial infections, including Covid-19, and for treatment of established infection and infectious inflammation. The composition includes a novel combination of vitamin, mineral, nutraceutical and phytochemical supplements. The composition of supplements and method may be compounded as a pill, tablet, powder, capsule or liquid be taken orally one or more times per day, and parenteral including nasal sprays and inhalers. Vitamin C and vitamin E along with zinc complexed with pyrithione or citrate are used in conjunction with nutraceuticals and phytochemicals provided, respectively, as immune boosters and antiviral agents along with anti-inflammatory nutraceuticals and phytochemicals.

The invention discloses a preparation method and application of a novel hydrogel immunopotentiator, and belongs to the technical field of veterinary medicine. The preparation method comprises the following steps: adding a ferric trichloride solution into a hyaluronic acid solution, reacting in a stirring state, then adjusting the pH value to 5.5-7.5, and stirring to obtain hyaluronic acid hydrogel; 2 ', 3'-cGAMP with the final concentration of 0.1-800 g / mL is added into the hyaluronic acid hydrogel, and the hydrogel immunopotentiator is obtained. The invention also discloses an application of the hydrogel immunopotentiator in an alumina gel inactivated vaccine. The immunopotentiator disclosed by the invention has a 3D network structure, so that an agonist can be efficiently delivered to drainage lymph nodes in a targeted manner, systemic inflammatory reaction is avoided, and the immunopotentiation effect of the immunopotentiator is better exerted; when being used for the porcine epidemic diarrhea alumina gel inactivated vaccine, the porcine epidemic diarrhea alumina gel inactivated vaccine not only can obviously up-regulate the level of a serum neutralizing antibody, but also can effectively induce immune response of Th1 type cells and provide stronger immune protection response.

The present application relates to the medical immunological in-vitro diagnosis field, provide a kind of for AD marker detection composite immunopotentiator, including 2-methyl acryloyloxy ethyl phosphoryl choline copolymer, polyethylene glycol 20000, polyvinylpyrrolidone-10 and membrane lysing agent.The present application also provides the application of the above-mentioned composite immunopotentiator in the preparation of the kit for detecting Alzheimer's disease biomarker.The present application has the advantages that: the composite immunopotentiator is added to the reagent R1 and reagent R2 of the existing AD marker detection kit, can accelerate the reaction, shorten the immune response time, improve the detection sensitivity and accuracy, and keep stable.

The invention relates to the technical field of animal husbandry and veterinary medicine, and discloses a compound preparation for preventing and treating ruminant rumen acidosis, and the compound preparation comprises the following raw materials by mass: 50.0-70.0% of sodium bicarbonate; 10.0% to 20.0% of magnesium oxide; 0.5% to 2.0% of resveratrol; 0.5% to 1.5% of taurine; 1.0%-3.0% of a hawthorn extract; 1.0% to 5.0% of a bacillus subtilis agent; 0.5%-1.5% of a berberine extract; 1.0%-3.0% of compound vitamin B; 1.0%-3.0% of astragalus polysaccharide; 5.0% to 10.0% of saccharomyces cerevisiae; according to the formula, gastric acid is rapidly neutralized through the alkaline buffer agent, rumen micro-ecological balance is rebuilt in combination with the probiotic flora, excessive proliferation of acid-producing bacteria is inhibited by utilizing the plant extract, damaged mucous membranes are repaired, and the disease resistance of a body is improved in cooperation with the immunopotentiator; a multi-dimensional synergistic effect system of acid-base regulation, flora repair, mucous membrane protection and immune enhancement is formed, and the problems that a traditional scheme is single in action dimension, insufficient in curative effect durability and incapable of coping with a complex pathological process are solved.

The invention discloses a lactic acid bacteria bionic extracellular vesicle as well as a preparation method and application thereof, and belongs to the technical field of medical materials. According to the preparation method of the lactic acid bacteria bionic extracellular vesicles disclosed by the invention, lactic acid bacteria cells are efficiently broken by utilizing a high-pressure homogenization technology, and the lactic acid bacteria bionic extracellular vesicles are separated and purified by adopting differential and ultraspeed centrifugation. The preparation method disclosed by the invention is simple and controllable in process, and large-scale amplification and standardized production are easy to realize; the obtained bionic extracellular vesicles of lactic acid bacteria are higher in yield and uniform in particle size than natural extracellular vesicles, have similar safety to the natural extracellular vesicles of lactic acid bacteria, and can promote immune maturation of dendritic cells and drug delivery carrier activity. The compound can be used as a vaccine adjuvant, an immunopotentiator and a vaccine and nano-drug delivery carrier to be applied to the field of biological medicine.

This invention relates to the field of aquaculture technology, and in particular to an immune enhancer for juvenile large yellow croaker (Culter alburnus), its preparation method, and its application. The immune enhancer provided by this invention, through the compounding of specific components in a specific ratio, achieves the synergistic effect of polypeptides, immunopolysaccharides, antioxidants, and nutritional factors, while also considering rapid absorption, immune regulation, and high-temperature environmental stability. It is suitable for the immune enhancement needs of large yellow croaker juveniles under high-temperature seawater conditions of 29-31 °C, and can enhance the non-specific and specific immunity of juveniles under high-temperature seawater conditions, improving disease resistance and survival rate.

The invention discloses self-assembled gE nanoparticles as well as a preparation method and application thereof, and relates to the technical field of biomedicine. The self-assembled gE nanoparticle is formed by polymerizing a plurality of monomers, and the monomers comprise a varicella-zoster virus gE and a varicella-zoster virus gI polypeptide containing a Th epitope. The self-assembled gE nanoparticles provided by the invention can be applied to VZV vaccines, and solves the technical problems of weak gE immunogenicity and serious vaccine side reaction in vaccines prepared in the prior art. Compared with the Xinanlietaine, the vaccine taking the self-assembled gE nano-particle as the antigen has the advantages that the variety and dosage of an immunopotentiator are less, the immunogenicity is better, and the clinical side reaction is lower; besides, the self-assembled gE nanoparticle vaccine not only can induce a gE specific CMI reaction, but also can induce a gI specific CMI reaction, so that the effectiveness of the vaccine is further improved. In a word, the self-assembled gE nanoparticles have good clinical application potential.

The present application relates to the technical field of biological medicine, disclose a kind of containing low molecular weight glucuronan-xylan immunopotentiator.The immunopotentiator described in the present application uses low molecular weight glucuronan-xylan as active substance, wherein the average molecular weight of low molecular weight glucuronan-xylan is 0.7-0.9kDa.Compared with the existing glucuronan-xylan, the present application has a lower molecular weight and a narrower molecular weight range, which makes the immunopotentiator containing low molecular weight glucuronan-xylan prepared by the present application have good solubility and smaller viscosity, so that glucuronan-xylan can be better absorbed by immune cells and better reflect the effect of improving immunity.

The invention discloses self-assembled herpes virus gE nanoparticles as well as a preparation method and application thereof, and relates to the technical field of biomedicine. The self-assembled herpes virus gE nanoparticles are formed by self-assembling a plurality of monomers; the monomers include herpes virus gE and VZVgI polypeptides. The self-assembled herpesvirus gE nanoparticles can be applied to VZV and / or HSV-1 type and / or HSV-2 type vaccines, and the technical problems that the gE immunogenicity is weak and the vaccine side reaction is serious are solved. The VZV gI polypeptide and the herpes virus gE are subjected to fusion expression to prepare the self-assembled herpes virus gE nanoparticles, the preparation method is simple, and the immunogenicity of the gE is remarkably enhanced; according to the vaccine containing the nanoparticles, the immunogenicity of the vaccine can be better than that of the vaccine in the prior art, and the use of an immunopotentiator can be reduced, so that the inflammatory reaction induced by the immunopotentiator is reduced, and the clinical side reaction of the vaccine is finally reduced.

Compositions and methods for protecting against a wide spectrum of viral and bacterial infections, including Covid-19, and for treating established infection and infectious inflammation are described. The composition includes a novel combination of vitamins, minerals, nutraceuticals, and phytochemicals, which may be compounded as a pill, tablet, powder, capsule or liquid to be taken orally or via other administration routs one or more times per day, to serve as immune boosters, antibacterial agents, and antiviral agents along with providing anti-inflammatory effects in humans and animals.

The application discloses a veterinary compound water-soluble adjuvant and a preparation method thereof, and belongs to the technical field of vaccine adjuvants. The application provides a veterinary compound water-soluble adjuvant to solve the problem of poor biocompatibility of traditional adjuvants in the prior art and to provide a stable and efficient novel carbomer adjuvant. The veterinary compound water-soluble adjuvant is composed of 10%-30% crosslinked polymers, 1%-6% solution stabilizers, 2.5%-7.5% polysaccharide immunopotentiators and 56.5%-86.5% solvents. The four components are mutually restrained and mutually enhanced, physical slow release-chemical activation-local low stimulation integration is realized, and it is proved that each component is indispensable in a limited proportion, so that a better adjuvant selection is provided for the market.

This invention belongs to the field of vaccine preparation technology, and discloses the application of Streptococcus suis type 2 membrane vesicles in the preparation of vaccines and / or immune enhancers. This invention is the first to use Streptococcus suis type 2 membrane vesicles as a vaccine for animal immunization. Animal experiments have demonstrated that the Streptococcus suis type 2 membrane vesicles of this invention can induce high levels of antibodies and have a significant effect in preventing Streptococcus suis type 2 infection. It can be developed and applied as a novel vaccine to prevent Streptococcus suis type 2 disease and avoid bacterial resistance, demonstrating good practical application value. Simultaneously, this invention also discloses a vaccine for preventing Streptococcus suis type 2 and an immune enhancer.