493 results about "Inositol" patented technology

Disclosed herein are crystalline forms of phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) isoform alpha (PI3Kα) inhibitors, and formulations and uses of same.

The invention provides a repairing and anti-aging composition specially researched for dry sensitive skin and application of the repairing and anti-aging composition, and belongs to the technical field of cosmetics. According to the anti-aging composition disclosed by the invention, inositol, ceramide-NP, phytosphingosine, a golden camellia extract, a waxberry bark extract and a fructus cnidii extract are selected according to a specific mass ratio, and the six components are combined for use, so that a strong anti-aging network can be formed, and a plurality of aspects act together, so that the anti-aging composition has a good anti-aging effect. The permeation promoting, repairing, moisturizing, anti-aging and soothing effects of the anti-aging composition are improved.

The embodiment of the invention discloses a novel fish acute septicemia detection system based on hyperspectral imaging. The system comprises a data acquisition module, a model detection module and a user interaction module, wherein the data acquisition module acquires hyperspectral image data on the surface of a target fish body; the model detection module carries out diagnosis by taking the hyperspectral image data as input based on a trained deep learning diagnosis model, and the deep learning diagnosis model obtains a pixel space structure and a pixel spectrum sequence of the fish body surface based on the hyperspectral image data; identifying spatial features representing related clinical symptoms based on a pixel spatial structure, and identifying spectral features representing an inositol metabolism condition based on a pixel spectral sequence; and the user interaction module outputs a diagnosis result of the target fish body based on a result output by the model. The characteristic that the aeromonas hydrophila utilizes inositol as a unique carbon source and the map change of typical infection symptoms on the surface of a fish body are combined, and accurate and rapid detection is achieved through hyperspectral imaging and a deep learning algorithm.

The invention belongs to the field of skin care products, and particularly relates to an anti-wrinkle and anti-aging composition as well as a preparation method and application thereof, and the anti-wrinkle and anti-aging composition comprises neurotransmitter inhibition peptide, signal peptide, madecassoside, inositol and glycosylglycerol. The neurotransmitter inhibition type peptide is at least three of acetyl hexapeptide-8, arginine / lysine polypeptide, dipeptide diaminobutyrylbenzylamide diacetate and acetyl octapeptide-3, and the signal type peptide is at least two of palmitoyl pentapeptide-4, decapeptide-4 and acetyl tetrapeptide-9. Compared with the prior art, all the components of the anti-wrinkle and anti-aging composition act on different anti-aging pathways and can be matched with one another from multiple aspects of oxidation resistance, inflammation resistance, moisturizing, cell viability enhancement, wrinkle reduction and the like, a more comprehensive and better anti-aging effect is provided, skin aging is comprehensively resisted, the skin is in a more young state, and the anti-wrinkle and anti-aging composition has the advantages that the anti-wrinkle and anti-aging effects are achieved. And the anti-wrinkle and anti-aging composition is small in irritation and good in stability.

The invention relates to a recombinant pichia pastoris strain capable of producing astaxanthin at high yield as well as a construction method and application of the recombinant pichia pastoris strain. The recombinant pichia pastoris strain is obtained by expressing ATP (adenosine triphosphate) citrate lyase (ACL) and acetyl-CoA synthase (ACS) or phosphoketolase (PK) and phosphotransacetylase (PTA), choline kinase (CK), inositol polyphosphate kinase (IPK) and vitreoscilla hemoglobin (VHB) in host bacteria. Wherein the host bacterium is a pichia pastoris gene modified strain PP-LC2. The astaxanthin production performance of the recombinant strain is verified on the basis of comparison of precursor supply pathways, IUP pathway construction and improvement of the oxygen supply capacity of the engineering strain, and the astaxanthin production capacity of the pichia pastoris is further improved. The construction method of the recombinant pichia pastoris is simple, the synthesis of astaxanthin can be better promoted, the engineering strain can efficiently synthesize the astaxanthin by utilizing methanol through amplification fermentation of a 5L fermentation tank, and industrial production is facilitated.

The invention belongs to the technical field of cosmetics, and discloses a wrinkle-removing and anti-aging composition containing recombinant collagen as well as a preparation method and application of the wrinkle-removing and anti-aging composition. The composition is prepared from the following components: 20.4 to 35.6 percent of glycerol, 1.1 to 3.5 percent of 1, 2-hexanediol, 8.2 to 15.4 percent of apple fruit cell culture extract, 1.6 to 3.2 percent of inositol, 0.2 to 1.0 percent of elastin, 0.1 to 1.7 percent of hydroxyproline, 0.1 to 1.0 percent of sodium polyglutamate, 0.1 to 1.0 percent of sodium hyaluronate, 0.01 to 0.1 percent of acetyl hexapeptide-8, 0.01 to 0.1 percent of fibronectin, 1.72 to 3.21 percent of soluble collagen and the balance of deionized water. The amino acid sequence of the soluble collagen is as shown in SEQ ID NO. 1. The skin care product prepared by adding the anti-wrinkle and anti-aging composition is good in safety and has the effects of resisting wrinkles, improving skin elasticity and resisting aging.

The invention discloses an inositol oxidase mutant and application thereof, and belongs to the technical field of gene engineering. The inositol oxidase mutant is obtained by mutating 113th amino acid of an amino acid sequence shown as SEQ ID NO.1, and the mutation is that the 113th amino acid is mutated from T to A. The enzyme activity of the inositol oxidase mutant is remarkably improved, the thermal stability is good, the half-life period is long, and the yield and conversion rate of glucuronic acid can be improved.

The invention relates to the technical field of biology, in particular to a sample preservation solution for vagina micro-ecology detection and a preparation method of the sample preservation solution. The invention relates to a sample preservation solution for vaginal micro-ecology detection. The sample preservation solution comprises the following components in percentage by mass: 0.5-0.9% of paraformaldehyde, 0.08-0.12% of glutaraldehyde, 10-18% of a buffer solution, 0.1-0.4% of inositol, 1-10% of a stabilizer, 0.8-5% of a cell treatment agent and the balance of water, the stabilizing agent is prepared from sodium alginate, tween-20 and beta-cyclodextrin. The invention aims to solve the problems of high false negative and false positive rate or difficulty in interpretation caused by liquid-based cell accumulation, unstable subsequent dyeing and decoloration time and the like of a cell preservation solution in the prior art, so that the sample preservation solution for sample cells can keep the forms of cells, protozoa and the like unchanged, and ensures that gram staining negative and positive properties of bacteria and fungi are not changed. The staining and decoloring are relatively stable, the false negative and false positive rate of sample cell detection is effectively reduced, and the sample cell lesion detection and judgment are more accurate.

The invention discloses a genetically engineered bacterium for producing glucuronic acid as well as a construction method and application of the genetically engineered bacterium, and belongs to the technical field of genetic engineering. According to the genetically engineered bacterium for producing glucuronic acid, an inositol oxidase gene MMIOX is integrated on a site of a uronic acid isomerase gene uxaC. According to the invention, an inositol oxidase gene MMIOX is integrated on a genome of a genetically engineered bacterium for producing glucuronic acid, and a uronic acid isomerase gene uxaC is knocked out at the same time, so that the genetically engineered bacterium can efficiently catalyze inositol reaction to generate glucuronic acid through the integrated inositol oxidase gene MMIOX; the glucuronic acid isomerase gene uxaC is knocked out, so that isomerization reaction of glucuronic acid can be avoided, and the yield of glucuronic acid is further increased.

The invention discloses a preparation method and processing equipment of herbal composite granules, and relates to the technical field of composite granules. Comprising the following components in parts by weight: 15-20 parts of soybean phospholipid, 10-15 parts of glutamine, 10-15 parts of L-arginine, 5-10 parts of a ginseng extract, 5-10 parts of phytosterol, 5-10 parts of xylooligosaccharide, 5-10 parts of inositol, 5-10 parts of a hawthorn extract, 5-10 parts of a blueberry extract, 5-10 parts of an acerola cherry extract, 0-5 parts of yeast beta glucan, 0-5 parts of a sea-buckthorn extract, 0-5 parts of a tartary buckwheat extract, 0-5 parts of haematococcus pluvialis and the like. The composition is innovative and breakthrough in successful application in the aspects of heart and cerebral vessels and anti-aging, and can regulate intestines, protect liver, reduce blood pressure and regulate blood fat; thrombus is melted, the vascular endothelial function is improved, and arteriosclerosis is prevented; meanwhile, the effects of resisting oxidation, resisting inflammation, resisting aging and enhancing immunity can also be achieved.

The invention discloses a method for preparing inositol, particularly relates to a method for converting glucose into inositol through in-vitro multi-enzyme catalysis, and belongs to the field of enzyme catalysis preparation of inositol. According to the invention, the phosphoglucose synthase capable of realizing phosphorylation of glucose by using inorganic phosphate is screened, and the inositol can be generated through conversion by taking glucose as a substrate, so that a novel method for synthesizing the inositol through enzyme catalytic conversion is provided. In addition, the invention further provides hexokinase capable of improving the yield of inositol, and the conversion efficiency of glucose is greatly improved. Furthermore, the invention provides a multi-enzyme molecular machine containing the glucose phosphate synthase and / or hexokinase, the multi-enzyme molecular machine is applied to preparation of inositol, and the reaction steps are simple, green and pollution-free.

The invention relates to the technical field of medicine analysis, in particular to a method for analyzing mutagenic impurities in a small molecule fungal inositol acyltransferase 1 inhibitor raw material medicine, the analysis method can be used for trace detection of potential mutagenic impurities I and II in the raw material medicine, the limit of quantitation concentration of the impurity I is not higher than 0.53 ng / ml, and the limit of quantitation concentration of the impurity II is not higher than 0.53 ng / ml. The detection limit concentration of the impurity I is not higher than 0.27 ng / ml; the quantitation limit concentration of the impurity II is not higher than 0.52 ng / ml, and the detection limit concentration of the impurity II is not higher than 0.26 ng / ml. The analysis method suitable for the mutagenic impurities in the small-molecule fungal inositol acyltransferase 1 inhibitor bulk drug is high in sensitivity and high in specificity, and the blank solvent does not interfere with detection of the impurities.

The invention discloses a method for biological high-density synthesis of retinaldehyde and a synthetic strain thereof. The synthetic strain is obtained by expressing ATP citrate lyase ACL, acetyl-CoA synthase ACS, choline kinase CK, inositol polyphosphate kinase IPK and vitreoscilla hemoglobin VHb in host bacteria. Wherein the host bacterium is a pichia pastoris gene modified bacterial strain PP-B2C. The retinaldehyde production performance of the recombinant strain is verified on the basis of a precursor supply pathway, an IUP pathway and a dissolved oxygen level, and the retinaldehyde production capacity of the pichia pastoris is further improved. The construction method of the recombinant pichia pastoris is simple, the synthesis of retinaldehyde can be better promoted, and the retinaldehyde can be efficiently synthesized by the engineering strain by utilizing glucose and methanol through amplification fermentation of a 5L fermentation tank, so that the recombinant pichia pastoris is beneficial to industrial production.

The utility model relates to a system for preparing high-purity inositol using corn slurry, the system comprising a precipitation tank, a first plate-frame filter, a fitin dissolving tank, an enzymolysis tank, a neutralization tank, a second plate-frame filter, a nanofiltration system, a first evaporator, a decolorizing tank, an ion exchange column, a second evaporator, a first crystallization kettle, a first centrifuge, a crude product dissolving tank, a second crystallization kettle, a second centrifuge, a hot air drying tank and a cold air fluidized bed connected sequentially by pipelines, a feed inlet of corn supernatant and a feed inlet of lime milk suspension are respectively arranged on the precipitation tank, a feed inlet of dilute hydrochloric acid solution is arranged on the fitin dissolving tank, and the material coming out of the discharge end of the cold air fluidized bed is the required inositol crystal product. The utility model can quickly obtain enzymolysis raw material liquid phytic acid, and compared with calcium phytate suspension, the homogeneity of the liquid phytic acid enzymolysis process system is improved, the enzymolysis conversion rate is increased to more than 98%, and the purity of the inositol crystal product is increased to more than 99.5%.

The utility model discloses an anti-blocking material transferring device for inositol production, which comprises a vacuum feeding machine, a first stock bin and a second stock bin which are communicated with one another, and a feeding valve is arranged at a feeding hole of the vacuum feeding machine; a material level sensor is arranged in the first stock bin, and a discharging valve is arranged at a discharging port of the first stock bin. The feeding valve and the discharging valve are interlocked with the material level sensor; the first stock bin is communicated with the second stock bin through a material conveying pipeline, a plurality of pressure sensors are arranged on the material conveying pipeline, a plurality of air nozzles are further arranged on the material conveying pipeline, and the air nozzles and the pressure sensors are arranged in a crossed mode; the plurality of air nozzles are respectively communicated with the compressed air storage tank through an air blowing valve and an air blowing pipeline; a discharge port of the first stock bin is communicated with a Roots blower, and an air outlet of the second stock bin is communicated with a Roots induced draft fan. According to the device, automatic transfer of inositol materials can be achieved, the transfer efficiency is high, secondary pollution to the environment is effectively avoided, and waste of the materials is avoided.

This disclosure provides compounds of Formula (X), and pharmaceutically acceptable salts thereof, that reduce levels of phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) isoform alpha (PI3Kα), as well as methods of making and using same, and compositions comprising Formula (X), and pharmaceutically acceptable salts thereof.

The invention belongs to the technical field of biological detection, and particularly discloses a cardiovascular marker substance control product and a preparation method thereof, the cardiovascular marker substance control product comprises a serum matrix, an antigen, a preservative and a stabilizer; the antigens comprise a cardiac troponin I antigen, a creatine kinase isoenzyme antigen, a myoglobin antigen, an amino-terminal brain natriuretic peptide precursor antigen, a brain natriuretic peptide antigen, a D-dimer antigen, a heart-type fatty acid binding protein antigen, a myeloperoxidase antigen and a lipoprotein phospholipase A2 antigen; the stabilizer comprises at least one of D-trehalose, cane sugar, glycine, inositol and polyethylene glycol. The cardiovascular marker substance control substance disclosed by the invention can cover various cardiovascular disease markers including heart failure, pulmonary artery embolism, vasculitis, atherosclerosis, myocardial injury, myocardial infarction and the like. The quality control product disclosed by the invention can be used as a third-party quality control product for screening cardiovascular diseases and performing indoor and interventricular quality control on an auxiliary diagnosis and measurement system.

The invention provides a fermented beverage capable of relieving fatigue and a preparation method of the fermented beverage, and relates to the technical field of functional beverages, and the IPC classification number belongs to A23L2. The fermented beverage is prepared from a radix astragali fermentation extract, a radix platycodonis extract, L-arginine, taurine, inositol, caffeine, nicotinamide, vitamin B6, L-lysine hydrochloride, pyrroloquinoline quinone and auxiliary materials. The astragalus mongholicus fermentation extract can improve the ATP generation efficiency, reduce lactic acid accumulation after exercise, relieve damage of oxidative stress to muscle and nerve cells and reduce immunosuppression caused by fatigue; the platycodon grandiflorum extract has the effects of refreshing mind and restoring consciousness, improving cognitive function decline caused by central fatigue, enhancing capillary permeability and promoting removal of metabolic wastes. The radix astragali fermentation extract and the radix platycodonis extract are compounded to achieve a synergistic effect, so that the composition has an excellent anti-fatigue effect. Under the combined action of all the components, fatigue is relieved, energy is rapidly supplemented, and physical strength is recovered.

The invention discloses a separation and preparation method of scyllo-inositol, and relates to the technical field of scyllo-inositol production, myo-inositol solution is added into whole-cell wet thalli containing inositol dehydrogenase and scyllo-inositol dehydrogenase, conversion is carried out in PBS buffer solution to obtain conversion liquid, the conversion liquid is filtered and decolorized by a ceramic membrane and an ultrafiltration membrane, and the scyllo-inositol is obtained. Then concentrating and centrifuging to obtain a mixed crude product of scyllo-inositol and inositol, pulping and washing with purified water, and drying a wet product to obtain scyllo-inositol. In the separation and preparation process, boric acid, strong acid, strong alkali and organic solvent are not used, precipitation of composite salt is not needed, the process steps are reduced, the environment is not polluted, the operation is safe, the recovery cost is low, materials are recycled, a complex recovery system is not needed, the cost can be better reduced, and the method is environment-friendly.

A C. glutamicum strain has enhanced productivity of L-lysine, and a method produces L-lysine using the C. glutamicum strain. The C. glutamicum strain expresses NAD(P)(+) transhydrogenase subunit alpha PntA and NAD(P)(+) transhydrogenase subunit beta PntB combined with increased activity of the myo-inositol transporter IolT. A method produces L-lysine in a fermentative process employing such C. glutamicum strain.

Conjugates comprising a fibroblast activation protein α (FAP-α)-targeted ligand, a bifunctional or trifunctional linker, and a phosphatidylinositol-3-kinase (PI3k) inhibitor; uses of the conjugates in the manufacture of a medicament for inhibiting progression of fibrosis in a subject; and a method of use in inhibiting progression of fibrosis in a subject.

The present invention relates to the field of cosmetics, and in particular to a tea fermentation composition and application that promotes the penetration of dual proteins. The tea fermentation composition of the present invention comprises black tea fermentation filtrate, whey protein, and recombinant collagen. The black tea fermentation filtrate used in the present invention contains more inositol and small molecule biological penetration-promoting polypeptides that promote skin penetration, which can effectively improve the antioxidant, anti-aging, and repair capabilities. After the black tea fermentation filtrate is compounded with whey protein and recombinant collagen, it can help solve the problem of the difficulty of dual protein penetration, thereby improving the utilization rate of dual protein in cosmetics, making it play its maximum effect, and achieving synergistic effect. The tea fermentation composition obtained by the present invention is added to cosmetics to greatly enhance the antioxidant, repair, anti-wrinkle and other effects.

Provided are methods of feeding a bird or feeding a population of birds by administering arginine silicate inositol. Also provided are methods of treating or preventing a myopathy in poultry. Also provided are methods for increasing poultry weight and improving poultry breast fillet quality. The methods include administering arginine silicate inositol or a composition comprising arginine silicate inositol to a bird or a population of birds. Also provided are compositions comprising arginine silicate inositol and at least one carrier.

The invention belongs to the technical field of insect feeding, and particularly relates to artificial feed for spodoptera frugiperda. Comprising the following raw materials in parts by mass: 10 to 30 parts of soybean meal, 30 to 50 parts of wheat germ, 70 to 100 parts of wheat bran, 10 to 50 parts of corn flour, 20 to 50 parts of crushed corn leaves, 15 to 40 parts of beer yeast powder, 5 to 30 parts of five-vitamin glucose, 5 to 20 parts of casein, 5 to 15 parts of ascorbic acid, 25 to 35 parts of agar powder, 0.5 to 2.0 parts of choline, 1.0 to 3.0 parts of sorbic acid, 0.1 to 0.5 part of inositol, 0.05 to 0.20 part of streptomycin sulfate, 1.0 to 3.0 parts of methyl parahydroxybenzoate, 15 to 30 parts of konjaku flour, 15 to 35 parts of milk powder, 0.2 to 2.0 parts of vitamin B6 and 1.0 to 1.0 part of corn germ oil. 5.0 parts of water and 1000 to 1500 parts of water. The artificial feed can significantly shorten the developmental duration of spodoptera frugiperda and improve the pupation rate and eclosion rate.

The invention relates to the technical field of biology, in particular to a recombinant strain for producing glucuronic acid and application of the recombinant strain. The invention provides a recombinant strain for producing glucuronic acid, and the recombinant strain does not express uronic acid isomerase and overexpresses inositol oxidase. The technical scheme of the invention has the following advantages: (1) uronic acid isomerase uxaC from escherichia coli K12 is knocked out, so that glucuronic acid accumulation is increased; and (2) successfully integrating the target gene of the inositol oxidase from the mouse into the escherichia coli K12MG1655. And (3) when the engineering strain is used for catalyzing inositol, the content of glucuronic acid in a system after the reaction is finished is 52.50 g / L, and the conversion rate is as high as 97.23%.

The invention discloses an enzyme preparation for catalytic synthesis of scyllo-inositol and a preparation method of scyllo-inositol, and belongs to the technical field of genetic engineering. The enzyme preparation has enzyme activity of catalyzing myo-inositol reaction to generate scyllo-inositol and comprises inositol dehydrogenase and scyllo-inositol dehydrogenase, and the amino acid sequence of the inositol dehydrogenase is shown as any one of (1) the amino acid sequence shown as SEQ ID NO.3; (2) an amino acid sequence as shown in SEQ ID NO.4; (3) an amino acid sequence as shown in SEQ ID NO.5; (4) an amino acid sequence as shown in SEQ ID NO.6; the amino acid sequence of the scyllo-inositol dehydrogenase is as shown in SEQ ID NO. 7. The specific sites of the wild type inositol dehydrogenase and the wild type scyllo-inositol dehydrogenase are mutated respectively, after mutation, the enzyme activity of the inositol dehydrogenase is higher, and the applicable pH range of the scyllo-inositol dehydrogenase is wider.

This disclosure provides processes of preparing compounds of Formula (I), such as (R)-1-(2-aminopyrimidin-5-yl)-3-(1-(5,7-difluoro-3-methylbenzofuran-2-yl)-2,2,2-trifluoroethyl)urea (Compound 1), and salts and / or solvates thereof, that inhibit phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) isoform alpha (PI3Kα).

The invention discloses children growth milk powder containing medicinal and edible components and capable of promoting height growth. The milk powder consists of the following raw materials: raw milk, skimmed milk powder, isomaltooligosacharide, demineralized whey powder, vegetable oil, milk mineral salt, medicinal and edible composite plant powder, arachidonic acid, docosahexaenoic acid, colostrum basic protein, hydrolyzed yolk powder, phosphatidylserine, enzymolysis bone meal, N-acetylneuraminic acid, probiotic powder, lactoferrin, vitamins, minerals and inositol. , choline, taurine and xanthophyll. The invention belongs to the technical field of dairy products, and particularly provides children growth milk powder containing medicinal and edible components and capable of promoting children's brain development, bone growth, digestion, absorption and utilization and improving children's immunity.

This disclosure provides compounds of Formula (I) and pharmaceutically acceptable salts thereof, that inhibit phosphatidylinositol 4,5-bisphosphate 3 kinase (PI3K) isoform alpha (PI3Kα). These compounds are useful for treating a disease in which increased PI3Kα activation contributes to the pathology, symptoms, and / or progression of the disease (e.g., cancer) in a subject.

The present invention relates to a (4R)-sulfonylamino-L-prolinamide compound having a general structure and a pharmaceutically acceptable salt or solvate thereof. The present invention also provides a method for preparing a (4R)-sulfonylamino-L-prolinamide compound and a pharmaceutically acceptable salt or solvate thereof. The present invention further provides the use of a (4R)-sulfonylamino-L-prolinamide compound and a pharmaceutically acceptable salt or solvate thereof in the preparation of a medicament for treating a disease by inhibiting phosphatidylinositol 3-kinase α (PI3Kα). The present invention further provides a drug combination comprising a (4R)-sulfonylamino-L-prolinamide compound and a pharmaceutically acceptable salt or solvate thereof. The (4R)-sulfonylamino-L-prolinamide derivative according to the present invention has favorable pharmacological properties, for example, they can inhibit PI3Kα, and are superior to Alpelisib in activity and selectivity for PI3Kα.