66results about How to "Stable source" patented technology

The invention provides a targeted giant salamander iridovirus nano antibody as well as a preparation method and application thereof. The invention discloses a giant salamander iridovirus targeting nano antibody, and aims to provide a giant salamander iridovirus targeting nano antibody which is low in expression cost, low in difficulty and stable in source, can be effectively combined with giant salamander iridovirus, and specifically realizes immunoassay of the giant salamander iridovirus. The amino acid sequences of the nano antibody are shown as SEQ ID NO.1-6, and the nano antibody belongs to the technical field of biological science.

The invention discloses a ternary sand-fixing water-retaining seepage-proofing fertility-increasing vegetation restoration and reconstruction method, and relates to the technical field of operation methods of sand ecological restoration, and the method comprises the following steps: S1, laying a layer of seepage-proofing material on the surface layer of a target planting area to reduce water seepage and enhance soil water-retaining capacity; s2, mixing a water-retaining agent with local sandy soil to form a water storage layer, and paving the water storage layer on the surface of the impermeable material to ensure that the plant root system can obtain water for a long time; s3, applying an organic fertility intensifier to the water storage layer to improve the organic matter content and nutrient supply capacity of the soil; s4, appropriate plants are selected for planting, after planting, the vegetation growth condition and the soil humidity are checked regularly, a water-retaining agent and an organic fertility increasing agent are supplemented in time according to needs, and it is ensured that the vegetation can grow healthily. The planting method provided by the invention has a remarkable yield increasing effect, the survival rate of plants can be effectively improved, and the effect of fixing sand for a long time is achieved.

The invention relates to a method for preparing spinnable mesophase pitch and carbon fibers from coal tar fractions, and belongs to the technical field of carbon materials. The method comprises the following steps: distilling and extracting aromatic hydrocarbon fractions in different distillation ranges from coal tar, activating the aromatic hydrocarbon fractions in one or more distillation ranges as raw materials, and carrying out non-catalytic polymerization reaction on one or more activated coal tar fractions and one or more non-activated coal tar fractions at a low temperature, and performing high-temperature polymerization reaction to obtain matrix asphalt, and performing reduced pressure distillation treatment, solvent extraction or inert gas purging to obtain the spinnable mesophase asphalt. The spinnable mesophase pitch has wide-area streamline optical texture distribution, good directional arrangement and orderliness, the mesophase content can reach 100%, the softening point is low, the coking value is high, the ash content is low, and the structure is controllable. The carbon fiber prepared based on the mesophase pitch is short in required oxidation time and has excellent performance.

The invention discloses a preparation method for preparing a silicon nitride substrate by adopting water-based tape casting silicon powder slurry in the technical field. The preparation method comprises the following steps: step 1) preparation of tape casting slurry: weighing silicon powder, an inorganic sintering aid, a dispersing agent, a water-based binder and a plasticizer; the preparation method comprises the following steps: adding a water solvent into silicon powder, carrying out ball milling, adding a water-based binder and a plasticizer into a ball milling tank, and defoaming slurry obtained after ball milling at a set vacuum degree to obtain slurry; (2) preparing a green body: carrying out tape casting on the adjusted slurry; and (3) degreasing: spraying and coating powder on the cut green body sheets of the silicon powder, stacking the green body sheets and then putting the green body sheets into a glue discharging furnace for degreasing to obtain a uniform and consistent degreased green body. And 4) sintering: transferring the degreased green body into a sintering furnace, raising the temperature to a nitriding temperature, firstly nitriding, then raising the temperature to a sintering temperature, carrying out heat preservation, and then carrying out furnace cooling to obtain the silicon nitride substrate. According to the invention, the cost is reduced on the premise of ensuring environmental protection.

The invention relates to an anti-aging composition containing recombinant collagen and a preparation method thereof. The main component of the composition is high-purity collagen obtained through a gene recombination technology, and various anti-aging active components such as sodium hyaluronate, vitamin C, coenzyme Q10 and vitamin E are combined. The invention also provides a preparation method, which ensures that each component is uniformly distributed and the biological activity is not damaged through low-temperature homogenization treatment and accurate proportioning. The composition disclosed by the invention can be used for remarkably promoting the proliferation of human skin fibroblasts and enhancing the expression of I-type collagen genes, and has a remarkable anti-aging effect. The composition is high in safety and remarkable in effect, is suitable for preventing and treating skin aging, and is widely applied to the fields of medicines and cosmetics.

The invention discloses spirulina alpha-glucan containing soluble dietary fibers and having immunomodulatory activity and a preparation method thereof, spirulina is subjected to continuous illumination culture under nutrient salt deficiency or low temperature or combined regulation and control of low temperature and nutrient salt deficiency; a large amount of alpha-glucan which contains more soluble dietary fibers and has immunoregulatory activity is accumulated in the spirulina, and the spirulina alpha-glucan is prepared by adopting a method of hot water extraction, trichloroacetic acid deproteinization and ethanol precipitation. The prepared spirulina alpha-glucan contains 10%-26% of dietary fibers, the content of the dietary fibers is 9-27 times higher than the content of the dietary fibers of maltodextrin, the spirulina alpha-glucan can induce secretion of NO, TNF-alpha and IL-6 of macrophages RAW264.7, the activation index of the NO reaches 1.5-3.6, the activation index of the TNF-alpha reaches 2.0-4.1, the activation index of the IL-6 reaches 1.6-3.0, and the spirulina alpha-glucan has a remarkable immunoregulation effect. Technical support and product cases are provided for development of spirulina glucan type high-added-value functional products.

The application relates to a YAG / Yb:YAG / YAG composite laser transparent ceramic and a preparation method thereof. The Yb:YAG water-based ceramic ink comprises mixed powder composed of Al2O3 powder, Y2O3 powder and Yb2O3 powder, the solid content is 20-25 vol%, the mole ratio of Al2O3, Y2O3 and Yb2O3 is 5:3-x:x, and 0 < x <= 0.3; the dispersant content is 0.2-0.8% of the mass of the mixed powder; the pH control agent is used in an amount controlled to adjust the pH of the Yb:YAG water-based ceramic ink to be between 10-11.5 and the pH of the ink is greater than or equal to 9.5 within 24 hours under the conditions of sealing and 20-25 DEG C; the humectant content is 5-20% of the total volume of the Yb:YAG water-based ceramic ink; the binder content is 0.1-0.5% of the mass of the mixed powder; and the sintering aid content is 0.1-0.5% of the mass of the mixed powder.

The present application relates to the technical field of metal material heat treatment, in particular to a heat treatment furnace device and method capable of controlling temperature and cooling speed, wherein the furnace body is internally constituted as a hearth, the output end of the air supply system is located at the lower region of the hearth through the furnace body; the flow equalizing system is arranged at the lower region of the hearth and is in communication with the output end of the air supply system; the workpiece is placed on the flow equalizing system; the circulation and exhaust system is arranged at the upper region of the hearth and is in communication with the interior of the hearth, the temperature monitoring system is arranged on the circulation and exhaust system and is directly above the workpiece; the control system is electrically connected with the air supply system, the circulation and exhaust system and the temperature monitoring system. The present application effectively solves the problems of insufficient cooling speed and poor cooling uniformity in the prior art.

The invention discloses a synthesis method of trans-4-(trans-4-methylcyclohexyl) cyclohexyl methanol, which comprises the following steps: step 1, taking 4, 4 '-biphenyldicarboxylic acid as a raw material, reacting with alkali to form salt, and performing catalytic hydrotreatment and acidification to obtain trans-4, 4'-biphenyldicarboxylic acid; step 2, the trans-4, 4 '-bicyclohexyl dicarboxylic acid is reduced into trans-4-(trans-4-hydroxymethyl cyclohexyl) cyclohexyl methanol under the action of a reducing agent, and the trans-4, 4'-bicyclohexyl dicarboxylic acid is reduced into the trans-4-(trans-4-hydroxymethyl cyclohexyl) cyclohexyl methanol under the action of a reducing agent; step 3, carrying out mono-esterification on the trans-4-(trans-4-hydroxymethyl cyclohexyl) cyclohexyl methanol, so as to form trans-4-(trans-4-hydroxymethyl cyclohexyl) cyclohexyl methanesulfonate; and step 4, reducing the trans-4-(trans-4-hydroxymethyl cyclohexyl) cyclohexyl methanesulfonate through lithium aluminum hydride, so as to obtain the trans-4-(trans-4-methyl cyclohexyl) cyclohexyl methanol. The designed route is unique, the raw materials are cheap and easy to obtain, the process conditions are reasonable, the product quality and cost are controllable, the total yield can reach 75% or above, aftertreatment is simple, isomerization is not needed, and the trans-98% or above product can be obtained.

The present application relates to adsorption separation of bisphenol A and 2,4-bisphenol A adsorbent and its adsorption separation process; the adsorbent is a high-silicon Y molecular sieve containing rare earth, the molar ratio of the contained silicon oxide and aluminum oxide is 2.5:1-15:1, the contained rare earth metal is one or a combination of multiple of lanthanum, cerium, scandium and yttrium, the content of rare earth metal is 10:1-1000:1 in terms of the molar ratio of silicon and rare earth metal, and the rare earth metal exists in the form of metal ions. The adsorption separation process is to contact the mixture containing bisphenol A, 2,4-bisphenol A, triphenol and chroman in the crystallization mother liquor with the adsorbent in the adsorption separation reactor to carry out adsorption separation, and the obtained bisphenol A and 2,4-bisphenol A after adsorption separation enter the isomerization reaction unit; the obtained triphenol and chroman after adsorption separation enter the cracking reaction unit. Phenol is used as the eluent, has strong affinity with the adsorbent, and the elution efficiency reaches more than 95%.

The present invention discloses a method for cultivating greater amberjack seedlings in an indoor cement pool, comprising the following steps: fertilized egg hatching, environmental regulation, bait and feeding methods, net-pulling training, and fish screening and pool division. The method adopts cement pool cultivation, and through water quality regulation, water flow environment regulation, and light environment regulation, selects nutritious oyster fertilized eggs instead of rotifers as the starter bait for fry, and through step-by-step net-pulling training, and cultivating seedlings of different specifications in different pools, the hatching rate of greater amberjack fertilized eggs and the survival rate of newly hatched fry are improved. The present invention also provides the use of the above method in improving the hatching rate of greater amberjack fertilized eggs, improving the weight, total length, survival rate, and yield rate of greater amberjack fry, improving the expression of genes related to muscle growth and development of greater amberjack, improving the microbial species coverage, richness, and diversity of greater amberjack intestinal flora, regulating the composition structure of greater amberjack intestinal microbial colonies, and increasing the proportion of beneficial bacteria in the flora or improving intestinal health.

This invention discloses an N,S co-doped ultraporous carbon material, its preparation method, and its applications. The method involves synthesizing a precursor PS-3 via polymerization using 3-cyanopyridine and p-toluenesulfonic acid as raw materials. The precursor PS-3 is then subjected to high-temperature carbonization at different temperatures to obtain the N,S co-doped ultraporous carbon material with pore size. This invention eliminates the activation step, requiring only one reaction step, with mild reaction conditions and simple equipment. The ultraporous pores obtained in this invention have a pore size <0.6 nm, classifying them as ultraporous. This is mainly due to their lack of nitrogen adsorption but high carbon dioxide adsorption, indicating the presence of numerous ultraporous structures with pore sizes around 0.33 nm. The specific pore size and pore area were then determined using 195K carbon dioxide. Testing showed that the material can be used for ethane / ethylene adsorption separation, exhibiting excellent adsorption separation performance and a large adsorption ratio.

The invention provides an efficient modified plant-based water nitrate bio-adsorbent and a preparation method thereof. Compared with a traditional activated carbon adsorbent, the prepared efficient modified plant-based water body nitrate bio-adsorbent has the advantages that the specific surface area is larger, nitrate in a water body can be effectively removed, the continuous and efficient adsorption effect on the nitrate is achieved within the adsorption time of 15-180 min, the cost of albizia hardtii seed raw materials is extremely low, and the environment-friendly effect is achieved. The raw materials are stable in source and easy to obtain, and good economic and social benefits are achieved.

The invention discloses a synthesis method for preparing a fluorine-containing biphenyl compound by a one-pot method, which comprises the following steps: taking fluorine-containing bromobenzene 1A as an initial raw material, reacting with magnesium to generate fluorine-containing phenyl magnesium bromide, reacting with (RO) 3B, hydrolyzing to generate fluorine-containing aryl boric acid ester C, and carrying out coupled reaction with aryl chloride 2A to obtain a target product fluorine-containing biphenyl B; in the formula, R1 is H, F, C1-C6 alkyl and C1-C6 alkoxy; the R group is C1-C6 alkyl, and the R2 group is any one of H, F, C1-C6 alkyl, C1-C6 alkoxy, hydroxyl, nitryl, ester group and carbonyl. According to the method, fluorine-containing bromobenzene is used as a raw material, fluorine-containing phenyl magnesium bromide is prepared from fluorine-containing bromobenzene and magnesium, fluorine-containing phenyl magnesium bromide reacts with boric acid ester and is hydrolyzed to prepare fluorine-containing aryl boric acid ester, and aryl chloride is directly coupled to obtain a target product fluorine-containing biphenyl through a one-pot method without treatment; the method is simple and convenient, can be completed in one pot without post-treatment, and is high in yield and controllable in cost.

The invention discloses a method for extracting prenuclide and preparing medical alpha isotope on a large scale based on monazite discharged waste slag. According to the method, high-value conversion of radioactive waste is realized by comprehensively utilizing the monazite waste slag. The alpha isotope is used as a core raw material for extracting preposed nuclide, so that the environmental harm of radioactive waste residues is reduced, waste is turned into wealth, and a stable raw material source is provided for preparing the medical alpha isotope. A complete technical chain for extracting the medical alpha isotope 225Ac / 212Pb from the monazite waste slag containing 226Ra and 228Ra is constructed, and efficient output of high-value nuclides is achieved. 226Ra and 228Ra in the discharged waste slag are obtained through a step-by-step extraction process flow of a coarse radium product and a fine radium product, a radium target of an ECANS device is manufactured, and hot medical alpha isotopes such as 225Ac, 212Pb and the like can be prepared on a large scale by utilizing a photo-nuclear reaction. According to the preparation mode, the utilization rate of the discharged waste slag is increased, and the requirement of radioactive diagnosis and treatment on the medical alpha isotope can be met.

This invention belongs to the field of coating technology and provides a wear-resistant coating for drone shells and its preparation method. The raw materials of the coating include: hydrogenated bisphenol A epoxy resin, vinyl-terminated fluorinated polybutadiene resin, core-shell powder, aluminum borate nanofibers, polyetherimide micro powder, wear-resistant additives, silane coupling agent KH-792, light stabilizer, leveling agent and environmentally friendly solvent. The preparation method includes: (1) mixing hydrogenated bisphenol A epoxy resin and vinyl-terminated fluorinated polybutadiene resin to form a resin matrix; (2) first adding core-shell powder and aluminum borate nanofibers to the resin matrix for dispersion; after cooling to 25-30℃, adding other raw materials, stirring and defoaming to obtain the finished product. This coating has high wear resistance, wind and sand erosion resistance, low temperature crack resistance, microcrack self-repair, strong UV aging resistance and high adhesion, which can significantly improve the long-term service stability and service life of drone shells in complex and harsh environments such as high altitude, wind and sand, high and low temperature alternation, and strong ultraviolet radiation.

The invention relates to the technical field of biomass resource utilization, in particular to a straw yellow silage resource utilization method. According to the method disclosed by the invention, the corn stalk yellow silage is used as a raw material, and xylose can be prepared through crushing, pretreatment, material system replacement and hydrolysis, so that resource utilization of the corn stalk yellow silage is realized; according to the method, the yellow corn silage is adopted as the raw material, the primary problem of'storage and transportation 'of straw as the raw material in the prior art is solved, meanwhile, pretreatment is simpler and more environmentally friendly, hydrolysis conditions are milder, the requirement for equipment is low, the method is environmentally friendly, production energy consumption can be effectively reduced, meanwhile, the xylose yield is high, and follow-up fermentation is not inhibited; the relation among five-material utilization of the straws is enhanced, and the comprehensive utilization capability is improved.

The invention discloses a preparation method and a use method of sulfate reducing bacteria modified nanoscale zero-valent iron, and particularly relates to the field of water environment pollution remediation. Comprising a preparation method of the sulfate reducing bacteria modified nanoscale zero-valent iron, and a method for removing sulfamethoxazole (SMX) in a water body by using the sulfate reducing bacteria modified nanoscale zero-valent iron and the sulfate reducing bacteria modified nanoscale zero-valent iron. Compared with physical and chemical sulfur modified nZVI preparation methods, the preparation method disclosed by the invention is more environment-friendly and free of energy, ball-milling wastes or chemical agent wastes are remained, and the raw material source of the process is stable; the SRB-nZVI modified nano zero-valent iron material (SRB-nZVI) has the advantages that SMX can be more efficiently and quickly removed by the aid of the prepared SRB-nZVI modified nano zero-valent iron material as compared with single action of nZVI or SRB (sulfate reducing bacteria) liquid, the SRB-nZVI modified nano zero-valent iron material has the advantages that the SRB-nZVI modified nano zero-valent iron material can be obviously improved in removal rate and removal rate in 7 h as compared with single removal of SMX by the nZVI, the removal rate in 7 h can reach 75%, and the final removal rate can reach 93% or above.

The utility model discloses an industrial silicon flue gas comprehensive treatment system capable of reducing pollution and carbon, which comprises a flue, a waste heat boiler, an SDS (Sodium Dodecyl Sulfate) dry desulfurization device, a cloth bag dust removal device, an SCR (Selective Catalytic Reduction) denitration device, a carbon capture device and a chimney which are sequentially communicated, and the waste heat boiler is connected with the carbon capture device through a steam pipeline. A large amount of system energy consumption can be saved, the occupied area is small, the process technology is simple and practical, and operation is stable. The desulfurizer is wide in source, low in price, few in by-products, high in sodium sulfate content and convenient to use. And due to the recovery of the silica fume, the enterprise benefit is improved, and the secondary pollution is reduced. The medium and low temperature SCR denitration reduces the poisoning and blocking risks of the catalyst, prolongs the service life of the catalyst, reduces the operation cost, and can adapt to the complex and changeable flue gas working conditions of the industrial silicon electric furnace.

The present application relates to the technical field of immunological detection, in particular to hepatitis B PreS1 antigen and its preparation method and application. The present application first selects an active PreS1 polypeptide sequence, which is coupled to a hepatitis B surface antigen HBsAg molecule through a crosslinking agent to obtain a hepatitis B PreS1 antigen having both hepatitis B surface antigen activity and PreS1 antigen activity, which can be used as a calibrator and positive control in a hepatitis B PreS1 antigen detection kit. The kit uses anti-PreS1 antibody as coating and anti-HBsAg antibody as enzyme label. The artificial coupled hepatitis B PreS1 antigen prepared by the present application can effectively replace the currently used PreS1 real positive sample on the market, has no biological safety risk, stable source, and various indexes such as reactivity, vehicle stability and thermal stability, which are all better than those of the real positive sample, and has high innovation and applicability.

This invention provides a nanobody targeting carp herpesvirus type II and its application. The amino acid sequence of the nanobody is shown in SEQ ID NO. 1-6. The method includes immunizing alpacas with inactivated carp herpesvirus type II, collecting peripheral blood from the immunized alpacas and separating lymphocytes, and extracting total RNA; synthesizing cDNA by reverse transcription, and amplifying the gene fragment encoding the nanobody; ligating it into the pComb3xss vector, and then transforming it into competent cells to construct a nanobody phage display library; enriching and panning the inactivated virus as a coating antigen to obtain specifically binding phage particles; transforming the selected positive clones into host bacteria for induced expression; and obtaining the anti-carp herpesvirus type II nanobody after separation and purification. This invention aims to provide a carp herpesvirus type II nanobody that is low in expression cost and difficulty, has a stable source, can effectively bind to carp herpesvirus type II, and specifically achieves immunoassay of carp herpesvirus type II.

The application provides an operation circuit and a microprocessor architecture, which are applied to the technical field of computers, and the circuit comprises a gating circuit and a multiplier. The operation circuit is responsive to a switching control signal. In a first mode, the operation circuit controls the gating circuit to send a real operand pair (a, b) into the multiplier for operation. Alternatively, in a second mode, the operation circuit is responsive to the switching control signal to send a non-zero mask data pair into the multiplier for operation. In this way, the multiplier has data input and performs operation in any clock cycle, that is, the multiplier is continuously in a running state. The power consumption generated by the running of the multiplier is maintained stable, and differential power consumption characteristics are not generated. The side channel attack of an attacker to obtain sensitive information by analyzing the power consumption characteristics is prevented, the security of the password operation is improved, and security vulnerabilities are eliminated.

The invention relates to the technical field of medical health care products, in particular to an anticancer composition containing phellinus igniarius extract and total ginsenoside and application of the anticancer composition. The anticancer composition comprises a phellinus igniarius extract and total saponins of ginseng. The mass ratio of the phellinus igniarius extract to the total ginsenoside is 1: (0.5-2); the phellinus igniarius extract is obtained by taking artificially cultivated phellinus igniarius as a raw material through ultrasonic-assisted extraction and reflux extraction in stages; the extraction solvent is selected from water or an ethanol water solution with the ethanol concentration not exceeding 40%. The anticancer composition provided by the invention has remarkable in-vitro anticancer activity and low toxicity to normal cells.

The invention relates to YAG / Yb: YAG / YAG composite laser transparent ceramic and a preparation method thereof. Wherein the adopted Yb: YAG water-based ceramic ink comprises mixed powder composed of Al2O3 powder, Y2O3 powder and Yb2O3 powder, the solid content is 20-25 vol%, and the molar ratio of Al2O3 to Y2O3 to Yb2O3 is 5: (3-x): x, 0lt; x is smaller than or equal to 0.3; the content of the dispersing agent is 0.2-0.8% of the mass of the mixed powder; the dosage of the pH control agent is controlled to adjust the pH of the Yb: YAG water-based ceramic ink to be 10-11.5, and the pH of the ink is greater than or equal to 9.5 within 24 hours under the conditions of sealing and 20-25 DEG C; the content of the humectant is 5-20% of the total volume of the Yb: YAG water-based ceramic ink; the content of the binder is 0.1-0.5% of the mass of the mixed powder; and the content of the sintering aid is 0.1-0.5% of the mass of the mixed powder.

The invention relates to the technical field of agricultural cultivation and agricultural environmental protection, and particularly discloses a Xinjiang pollution-free soilless seedling culture substrate which is prepared by taking sick cotton straws, waste fungus bags or cotton seed shells, sawdust and barnyard manure as composting materials and adding urea, bran, a fermentation inoculant and water; the invention further provides a preparation method. The raw materials of the substrate are mainly wastes, are low in cost, low in price, easy to obtain, free of soil, good in water-retaining property, free of insecticides and bactericides, free of pollution, long in high-temperature fermentation time and capable of completely killing sclerotia, pests, worm eggs and seeds, and diseases are few after the substrate is used.

The invention belongs to the technical field of biology, and particularly relates to a recombinant protein for normalization monitoring of H7N9 subtype avian influenza virus in poultry farms and a preparation method and application of the recombinant protein. DIVA detection polypeptide and Escherichia coli thioredoxin (TrxA) are fused, and the recombinant fusion protein is expressed in a prokaryotic expression system. In addition, the purified polypeptide fusion protein is used as an antigen to establish an ELISA method. The method can only react with the serum of the chicken infected by the H7N9 subtype avian influenza virus. The cost for expressing and purifying recombinant protein in escherichia coli is obviously lower than that of chemically synthesized polypeptide, and the method is suitable for carrying out normalized epidemic disease monitoring in poultry farms. The recombinant fusion protein and the detection method thereof provided by the invention provide cheap and efficient diagnostic antigen and technology for carrying out normalized H7N9 subtype AIV detection in poultry farms.

The application discloses a kind of core-shell structure fast charging long cycle artificial graphite, its preparation method, negative electrode material and purposes, including, petroleum coke or acicular coke aggregate D50 8~20 μm, non-biomass hard carbon raw material powder D50 1~10 μm and pitch are mixed according to the mass ratio hard carbon: pitch = 1:9~5:5, aggregate: composite coating agent = 95:5~85:15, pre-mixing S1 is carried out at 100~200 DEG C, 160~220 DEG C melt kneading granulation S2, carbonization S3 is carried out at 600~1000 DEG C, and graphitization S4 is carried out at 2800~3200 DEG C, and core-shell structure artificial graphite is prepared by one-step method.The shell layer is composed of uniformly dispersed graphitized hard carbon and soft carbon, and is densely coated outside the artificial graphite core.The first reversible specific capacity of the product is greater than or equal to 350 mAh / g, the first coulombic efficiency is greater than or equal to 93%, and the capacity retention rate at 5.0C / 0.2C is greater than or equal to 84%, with excellent fast charging performance and cycle stability, simple process and low cost.

The application provides a compound omeprazole dry suspension and a preparation method thereof, and relates to the technical field of pharmaceutical preparations.The compound omeprazole dry suspension comprises the following raw materials: omeprazole, sodium bicarbonate, magnesium silico-aluminate, hard stearic acid modified hydrotalcite, low acyl gellan gum, hydroxypropyl methyl cellulose and trehalose.The application provides a compound omeprazole dry suspension and a preparation method thereof, and the compound omeprazole dry suspension with specific particle size is prepared through specific proportioning of auxiliary materials and a specific preparation process, and the stability and solubility are significantly improved.

The invention relates to the field of medicinal chemistry, and particularly discloses a novel TLR8 agonist intermediate as well as a preparation method and application thereof, which are suitable for process development of 4, 6-diaminopyridino [3, 2-d] pyrimidine TLR8 agonists. According to the preparation method, tert-butyl is adopted to replace 2, 4-dimethoxybenzyl to serve as an amino protecting group, so that the crystallization property of the intermediate is remarkably improved, column chromatography is avoided, the cost is reduced, and the process stability is improved. The preparation method of the TLR8 agonist intermediate comprises the steps of reduction, acylating chlorination, coupling, amination and the like, has the advantages of being easy and convenient to operate, high in yield, environmentally friendly and the like, and is particularly suitable for industrial production.

The present application provides a heating device, including a shell, a gas-liquid mixing chamber is formed inside the shell, a liquid inlet channel for conveying a fluid to be reacted toward the gas-liquid mixing chamber is arranged in the shell, and a catalytic reaction device is arranged on one side of the gas-liquid mixing chamber; a fan is arranged in the shell, and is used to convey air toward the gas-liquid mixing chamber, so that the air and the fluid to be reacted are mixed in the gas-liquid mixing chamber to form a mixture, and the mixture is blown into the catalytic reaction device for catalytic heat release, and the heat of the catalytic heat release is used for heat exchange in the methanol reforming process; at least one electric heating device is arranged in the shell, and is used to preheat the fluid to be reacted and / or the mixture. The heating device provided by the present application heats stably and evenly.