6 results about "Magnesium bromide" patented technology

The application discloses a kind of bromine iodine lead cesium perovskite solar cells of doping magnesium bromide prepared in low humidity environment and preparation method thereof, belong to perovskite photovoltaic technical field, including ITO transparent conductive glass and sequentially coated on ITO transparent conductive glass dense layer TiO2, SnO2 layer, bromine iodine lead cesium perovskite light-absorbing layer of doping magnesium bromide, 2,2',7,7'-tetra [N,N-di (4-methoxyphenyl) amino] -9,9'-spirobifluorene hole transport layer of doping lithium salt, silver electrode, and its preparation method is disclosed, the application is by doping into bromine iodine lead cesium perovskite precursor doping different molar magnesium bromide to optimize the energy level matching between perovskite and electron transport layer and hole transport layer, effectively reduce the recombination probability of carrier and improve the mobility of carrier, improve the crystal quality of perovskite thin film, to realize the light absorption coefficient of optimization light-absorbing layer, finally realize the improvement of bromine iodine lead cesium inorganic perovskite solar cell photoelectric conversion efficiency.

This invention discloses a berberine-dimethylaniline photosensitizer, its preparation method, and its application, belonging to the field of biomedical technology. The method involves sequentially reacting berberine with magnesium methyl bromide via Grignard addition, followed by bromomethylation with N-bromosuccinimide, and basic condensation with dimethylaminobenzaldehyde, then demethylating under high temperature and vacuum to obtain the active berberine-dimethylaniline. Finally, it undergoes weakly alkaline treatment to obtain the inactivated berberine-dimethylaniline. This invention introduces the electron-donating group dimethylaniline onto the berberine backbone, constructing an electron push-pull structure that red-shifts the absorption wavelength, facilitating deeper tissue penetration. Furthermore, this photosensitizer maintains high activity in the weakly acidic microenvironment of tumors while remaining inactive under normal physiological conditions, thereby achieving intelligent "on-off" regulation based on pH differences, improving the safety and precision of photodynamic therapy for tumors.

This invention relates to a method for preparing 1,4,5,8-tetramethoxynaphthalene compounds containing the characteristic side chain of shikonin and their 6-fluoro derivatives. The method uses 2-fluoro-1,4-dimethoxybenzene or 2,5-difluoro-1,4-dimethoxybenzene as starting materials. After cyclization, ring-opening, and O-methylation to construct the 1,4,5,8-tetramethoxynaphthalene core, an aldehyde group is introduced at the 2-position via Vilsmeier-Haack formylation. This is followed by addition with allyl magnesium bromide to obtain an allyl alcohol intermediate. Finally, a cross-metathesis reaction catalyzed by a Grubbs II catalyst is performed with 2-methyl-2-butene to construct the characteristic side chain of shikonin –CH(OH)CH2CH=C(CH3)2. This invention offers high yields, simple operation, avoids the use of highly toxic reagents, and successfully solves the problem of the difficulty in synthesizing 6-fluoro derivatives due to direct fluorination, providing a key intermediate for the development of novel naphthoquinone drugs.

This invention discloses a curcumin derivative with therapeutic effects on acute lung injury and its preparation method, comprising: dissolving curcumin in tetrahydrofuran, removing air from the reaction apparatus, and adding nitrogen to the reaction apparatus to fill it with nitrogen; then adding ethyl magnesium bromide and refluxing at a first preset temperature for 30 min; then adding succinic anhydride and refluxing at a second preset temperature for 4 h; stopping the reaction by adding water and adjusting the pH to 4 with hydrochloric acid; after extraction with ethyl acetate, purifying the upper layer using a preset method to obtain a yellow oily substance I-1; reacting curcumin succinate monoester I-1 with a 5% sodium bicarbonate solution, and evaporating the solvent to obtain curcumin succinate monoester sodium salt II. The raw material used in this invention has wide clinical applications and is safe and low in toxicity. The hydroxyl group of curcumin is combined with succinic anhydride through a Grignard reaction to form curcumin succinate monoester I-1, which is then reacted with sodium bicarbonate solution to obtain curcumin succinate monoester sodium salt II.

This invention discloses a method for synthesizing tri(p-tolyl)thionium hexafluorophosphate, comprising the following steps: di(4-chlorophenyl) sulfoxide is mixed uniformly with a solvent, and p-tolyl magnesium bromide is slowly added under an inert atmosphere. After stirring for 10 min, trimethylchlorosilane is added dropwise. After the reaction is complete, a 25 wt.% hydrobromic acid aqueous solution is added dropwise to quench the reaction. After extraction and vacuum concentration, tri(p-tolyl)thionium bromide is obtained. A potassium hexafluorophosphate aqueous solution is added to the tri(p-tolyl)thionium bromide and stirred. After the reaction is complete, the mixture is filtered, and the filter cake is recrystallized to obtain tri(p-tolyl)thionium hexafluorophosphate. This invention uses inexpensive and readily available raw materials, employs mild activation conditions, has high production safety, and achieves a yield of up to 71.34% for the obtained tri(p-tolyl)thionium hexafluorophosphate.

The application provides a preparation method of a natural product 6-HHS, which comprises the following steps: reacting a compound 1, sanguinare, with vinylmagnesium bromide to prepare a compound 2; and reacting the compound 2 with borane tetrahydrofuran complex to prepare 6-HHS. The application uses sanguinare as a raw material to prepare the natural product 6-HHS, has a short synthesis route, high synthesis efficiency, a yield of each step is more than 85%, the comprehensive yield of the natural product 6-HHS can reach 76%, and the operation is simple, the purity is high, and the application can provide a simple and efficient way for chemical synthesis of 6-HHS.