49 results about "Bromosuccinimide" patented technology

The invention belongs to the field of Velciguat synthesis, and particularly relates to a preparation method of Velciguat and an intermediate product thereof. The preparation method of the Velciguat comprises the following steps: (1) reacting aminomalononitrile with methyl chloroformate to generate an intermediate product I; (2) carrying out ring closing on the intermediate product I and formamidine under an alkaline condition to obtain an intermediate product II; (3) carrying out bromination reaction on the intermediate product II and N-bromosuccinimide to obtain an intermediate product III; (4) reacting the intermediate product III with bis (pinacolato) diboron under the action of a catalyst to obtain an intermediate product IV; and (5) carrying out a reaction on the intermediate product IV and 5-fluoro-1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo [3, 4-b] pyridine to prepare the viriciguat. The method is simple to operate, low in cost and safe in production. The invention also provides the intermediate product obtained by the preparation method.

The invention relates to a preparation method of alpha-bromo-carboxylic acid. The method comprises the following steps: under the protection of nitrogen, dissolving a malonic acid substrate, N-bromosuccinimide (NBS) and pyridine in a reaction solvent, and reacting for 1 hour at 50 DEG C under the irradiation of blue light; and separating the crude reaction product through column chromatography or preparative plate chromatography to obtain the target delta-bromo-carboxylic acid compound. The method has the advantages of mild reaction conditions, simple operation, easily available raw materials, low cost, and good functional group compatibility and substrate universality. In the obtained product, due to high reaction activity of bromine atoms, the bromine atoms can be further derived into various alpha-heteroatom substituted carboxylic acids, and the product has application potential in the fields of synthetic chemistry, drug research and development and the like.

The method for manufacturing an intermediate compound for shikonin synthesis of the present invention comprises the steps of: reacting 1,5-dihydroxynaphthalene with dimethyl sulfate to prepare 1,5-dimethoxynaphthalene; reacting 1,5-dimethoxynaphthalene with N-bromosuccinimide (NBS) to prepare 1,5-dibromo -4,8-dimethoxynaphthalene; introducing a methoxy group into 1,5-dibromo-4,8-dimethoxynaphthalene using copper iodide (CuI) and 1,10-phenanthroline as a catalyst to prepare 1,4,5,8-tetramethoxynaphthalene; performing formylation of 1,4,5,8-tetramethoxynaphthalene using phosphoryl chloride (POCl3) to prepare 2-formyl-1,4,5,8-tetramethoxynaphthalene; and forming a boron complex using pinacolborane (HBpin) and 3,3-dimethylallyl bromide and reacting the boron complex with 2-formyl -1,4,5,8-tetramethoxynaphthalene to prepare a prenylated shikonin intermediate. Compared to conventional synthetic methods, the method of the present invention offers milder reaction conditions, shorter reaction time, and improved yield, thereby greatly enhancing the economic feasibility of shikonin synthesis.

The invention belongs to the technical field of organic synthesis, and discloses a preparation method for trifluoromethylation of a 1, 6-enyne substrate. The preparation method comprises the following steps: in a protective gas atmosphere, mixing a 1, 6-eneyne substrate, NaSO2CF3, an oxidant, N-bromosuccinimide and an organic solvent, heating to react, cooling, separating an organic phase, drying and purifying to obtain a product after trifluoromethylation of the 1, 6-eneyne substrate, the organic solvent is selected from any one of dimethoxyethane and 1, 2-dichloroethane. The preparation method is mild in reaction condition, simple and convenient to operate, good in substrate applicability, good in substrate selectivity in reaction and high in target product yield, and a new way is provided for trifluoromethylation of the 1, 6-eneyne compound.

The application belongs to the technical field of organic synthesis, and provides a star structure carbazole derivative, a preparation method thereof and a carbazole conductive polymer. The application obtains an intermediate by mixing 10-phenyl-10H-phenothiazine, N-bromosuccinimide and a first organic solvent for reaction; obtains the star structure carbazole derivative by mixing the intermediate, 9H-carbazole-2-boronic acid pinacol ester, tetrakis(triphenylphosphine)palladium, an accelerator and a second organic solvent for reaction; and obtains the carbazole conductive polymer by mixing the star structure carbazole derivative and an electrolyte solution for cyclic voltammetry electrochemical polymerization. The method is simple, has few by-products, and the star structure carbazole derivative obtained by the method is a non-coplanar star structure, which is beneficial to the embedding and discharging of electrolyte ions, so that the carbazole conductive polymer has excellent electrochemical performance and energy storage properties, and the conductive polymer also has excellent electrochromic performance.

The invention discloses a preparation method of adamantyl triphenylamine, which comprises the following steps: 1, reacting o-aminobiphenyl with N-bromosuccinimide and an organic solvent to prepare an intermediate I; 2, adding 1-adamantanol and chlorobenzene into an organic solvent, and reacting under the action of strong acid to prepare an intermediate II; 3, adding the intermediate II, alkali and bis (pinacolato) diboron into an organic solvent, and reacting under the action of a palladium catalyst to prepare an intermediate III; and step 4, adding the intermediate III, the intermediate I, a palladium catalyst, alkali salt and tetrabutylammonium bromide into a mixed solution of toluene and deionized water, and carrying out Suzuki reaction to obtain adamantyl triphenylamine. The preparation method of adamantyl triphenylamine has the advantages of easily available raw materials, simple operation, high reaction yield in each step, high purity of the obtained product, and realization of industrialization.

This invention discloses a two-photon fluorescent dye, prepared as follows: 6-hydroxy-2-naphthaldehyde reacts with a dihaloalkane under alkaline conditions to obtain a monohaloalkane-based aryl ether, which is then reacted with an aqueous trimethylamine solution to prepare S1; diethyl 4-(4-tolyl)pyridine-2,6-dicarboxylate reacts with N-bromosuccinimide to obtain a brominated product, which is then reacted with triphenylphosphine to prepare S2. After intermediates S1 and S2 react under strongly alkaline conditions, the product is then hydrolyzed to prepare the target product. This dye exhibits good cell membrane permeability, good dispersion in the cytoplasm, preferentially targets organelles in the cytoplasm, is water-soluble, has very low toxicity, and a high two-photon absorption interface, making it suitable for two-photon fluorescence confocal microscopy imaging.

The application provides a kind of 3-bromofluorenone and preparation method thereof, it relates to the technical field of organic photoelectric material.The method is prepared by using 2-bromofluorenone and benzophenone imine under the condition of palladium catalyst to react 2-amino fluorenone, purification is convenient;Using 2-amino fluorenone and N-bromosuccinimide under ice water bath, the impurity can be controlled, purification is convenient, cost is controlled;Using with tert-butyl nitrite can obtain high purity 3-bromofluorenone compound target product;Using N-bromosuccinimide in ice water bath, accurately locate the 3 position of fluorenone, without the help of other catalysts, simplify the reaction;Using the way of dropping tert-butyl nitrite THF solution into the reaction system, can greatly improve the utilization rate of tert-butyl nitrite, finally improve the yield of the whole reaction.The preparation method provided by the application has the advantages of controllable impurity, easy purification and cost economy.

The invention relates to the field of drug synthesis, in particular to an amine compound for fungi drugs and a preparation method of the amine compound. Comprising the following steps: 1) adding N-bromosuccinimide (NBS) into 4-iodobenzene serving as an initial raw material in an acetonitrile solvent in the presence of benzoyl peroxide serving as a catalyst, and reacting to obtain a 1-bromomethyl-4-iodobenzene compound II; 2) adding N-methylacetamide into the compound II in a tetrahydrofuran solvent by using potassium carbonate as alkali, and reacting to obtain an N-(4-iodobenzyl)-N-methylacetamide compound III; and 3) heating the compound III in a sodium hydroxide solution for deacetylation to obtain the compound IN-methyl-1-(4-iodophenyl) methylamine. The invention aims to provide a preparation process of the N-methyl-1-(4-iodophenyl) methylamine compound I, which is simple, convenient, green, environment-friendly and suitable for industrial production.

The invention discloses a preparation method and application of a liquid reaction type bromine flame retardant, and belongs to the technical field of flame retardant preparation, and the preparation method comprises the following steps: mixing polypropylene glycol, tetrahydrofuran, N-bromosuccinimide, azodiisobutyronitrile and tetrahydrofuran for reaction, and performing post-treatment to obtain a brominated polyether polyol flame retardant; according to the invention, the prepared brominated polyether polyol flame retardant is also used in thermosetting resin to prepare a flame-retardant resin composition; according to the brominated polyether polyol flame retardant, the balance of high bromine content, high reaction activity and excellent synergism is realized; as a reactive flame retardant, the flame retardant not only can improve the flame retardant property of thermosetting resins such as polyurethane, but also can better retain the inherent physical and mechanical properties of a resin matrix.

The invention discloses a method for synthesizing 3-bromine-9-ethyl carbazole through reactive extrusion. The method comprises the following reaction steps: (1) adding uniformly mixed 9-ethyl carbazole, N-bromosuccinimide and a solid diluent into a solid feeding bin of a double-screw extruder; (2) adjusting the feeding speed and the screw rotating speed of the double-screw extruder, and dropwise adding auxiliary liquid through a peristaltic pump; and (3) collecting the product, dissolving, filtering, evaporating to remove the solvent and the like to obtain the 3-bromine-9-ethyl carbazole. According to the present invention, the double-screw extruder is adopted to efficiently prepare the 3-bromo-9-ethyl carbazole through the reaction extrusion, such that the use amount of the toxic and harmful solvent is substantially reduced, the product yield is improved, and the good application prospect is provided.

The application belongs to the technical field of pesticide intermediate preparation, and discloses a preparation method and application of 4-chloro-2,6-dimethylbromobenzene. The method uses 3,5-dimethylphenol as a starting material, and first reacts with p-toluenesulfonyl chloride under alkaline conditions to obtain 3,5-dimethylphenyl p-toluenesulfonate, then performs selective bromination with N-bromosuccinimide in the presence of a free radical initiator to obtain 4-bromo-3,5-dimethylphenyl p-toluenesulfonate, and finally performs a substitution reaction with a chlorine source such as concentrated hydrochloric acid or lithium chloride to obtain the target product 4-chloro-2,6-dimethylbromobenzene; the product can be used for synthesizing pesticides such as methoxypiperidine acetate and dispiro. The method realizes high-selectivity halogenation by regulating the electron cloud distribution of the benzene ring through functional group transformation, has mild reaction conditions, simple operation, avoids high-risk reagents and processes, has high yield, less waste, low cost, and is suitable for industrial production.

The application belongs to the field of vixepiromide synthesis, and particularly relates to a preparation method of vixepiromide and intermediate products thereof. The preparation method of vixepiromide comprises the following steps: (1) reacting aminopropandinitrile with methyl chloroformate to generate an intermediate product one; (2) ring closing the intermediate product one with formamidine under alkaline conditions to generate an intermediate product two; (3) performing bromination on the intermediate product two with N-bromosuccinimide to generate an intermediate product three; (4) reacting the intermediate product three with pinacol diboron under the action of a catalyst to generate an intermediate product four; and (5) reacting the intermediate product four with 5-fluoro-1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine to generate vixepiromide. The application has the advantages of simple operation, low cost and safe production. The application further provides the intermediate products generated in the above preparation method.

The application belongs to the field of pharmaceutical chemical industry, and particularly relates to a preparation method of a ticagrelor intermediate (1R, 2S)-2-(3, 4-difluorophenyl)cyclopropylamine, which comprises the following steps: taking compound II as raw material, and reacting with N-bromosuccinimide and sodium acetate to prepare target intermediate compound I. Compared with the prior art, the reaction has the advantages of mild reaction condition, simple operation, high safety, simple post-treatment, and safety and environmental protection. It is determined that the yield of the product prepared by the technical scheme disclosed in the application can reach more than 88%, and the purity is more than 99%.

This invention discloses a eutectic solvent and its preparation, a metal leaching agent, and a metal leaching method. The eutectic solvent is prepared by mixing choline chloride and a sulfonamide compound in a specific ratio; the sulfonamide compound is sulfonamide, 4-amino-N-(aminoiminomethyl)benzenesulfonic acid, or p-aminobenzenesulfonamide. This invention provides a metal leaching agent containing the aforementioned eutectic solvent, which is a transparent liquid prepared from the eutectic solvent and an auxiliary agent. The auxiliary agent is at least one selected from 1,3-dibromo-5,5-dimethylhydantoin, 1,3-dichloro-5,5-dimethylhydantoin, N-chlorosuccinimide, N-bromosuccinimide, chloramine T, and sodium hypochlorite. The eutectic solvent of this invention is an environmentally friendly compound, and the metal leaching agent system containing this eutectic solvent possesses both good oxidizing and coordinating abilities, enabling the leaching of gold and palladium with rapid leaching speed and high extraction rate.

The invention relates to the technical field of compound synthesis, in particular to a preparation method of N, N '-bis (2, 4, 6-trimethoxyphenyl) oxamide. The preparation method comprises the following steps: S1, bromination reaction: mixing dichloromethane, 1, 3, 5-trimethoxybenzene and triethylene diamine, adding NBS (N-bromosuccinimide) or dibromohydantoin, and reacting to obtain 1-bromo-2, 4, 6-trimethoxybenzene; s2, amination reaction: mixing an organic solvent, an acid binding agent, 1-bromo-2, 4, 6-trimethoxybenzene, a cuprous compound and a catalyst, and reacting to obtain 2, 4, 6-trimethoxyaniline hydrochloride; and S3, condensation reaction: mixing the 2, 4, 6-trimethoxyaniline hydrochloride with dichloromethane, adding triethylamine, and dropwise adding oxalyl chloride to obtain the N, N '-bis (2, 4, 6-trimethoxyphenyl) oxamide. The invention provides a preparation method of N, N '-bis (2, 4, 6-trimethoxyphenyl) oxamide, and aims to solve the problems of relatively slow reaction speed, incomplete reaction conversion, generation of impurities, poor product purity and low yield in a synthetic method in related technologies.

This invention discloses a method for preparing deuterated 1,2-dibromoethane, comprising the following steps: (1) adding tetradeuterium glycol, N-bromosuccinimide, and solvent into a reaction vessel; (2) controlling the temperature inside the reaction vessel at -5 to 20°C, and then adding a mixture of triphenylphosphine and solvent dropwise into the reaction vessel; (3) after the dropwise addition is completed, restoring the reaction vessel to room temperature, and controlling the reaction time to 0.5 to 1.5 h to obtain a product containing deuterated 1,2-dibromoethane. The reaction temperature of this invention is at room temperature, the reaction operation is simple, it meets the requirements of green chemistry, and it can be industrialized. Furthermore, the purity of deuterated 1,2-dibromoethane is above 98 wt%, and the yield of deuterated 1,2-dibromoethane is above 60 wt%.

This invention discloses a method for preparing bromobenzothiophene, relating to the field of organic synthesis. In the preparation of bromobenzothiophene, N-bromosuccinimide is first purified by recrystallization; benzo[b]thiophene is mixed evenly with acetonitrile, and then the purified N-bromosuccinimide is added in batches while stirring. Finally, deionized water is added to the reaction solution, followed by stirring, filtration, washing, and drying to obtain 3-bromobenzo[b]thiophene. The method for preparing bromobenzothiophene provided by this invention reduces the generation of toxic byproducts due to solvent substitution, resulting in a higher yield of bromobenzothiophene. Furthermore, the preparation method provided in this application can be carried out at a lower temperature, saving energy.

This invention discloses a berberine-dimethylaniline photosensitizer, its preparation method, and its application, belonging to the field of biomedical technology. The method involves sequentially reacting berberine with magnesium methyl bromide via Grignard addition, followed by bromomethylation with N-bromosuccinimide, and basic condensation with dimethylaminobenzaldehyde, then demethylating under high temperature and vacuum to obtain the active berberine-dimethylaniline. Finally, it undergoes weakly alkaline treatment to obtain the inactivated berberine-dimethylaniline. This invention introduces the electron-donating group dimethylaniline onto the berberine backbone, constructing an electron push-pull structure that red-shifts the absorption wavelength, facilitating deeper tissue penetration. Furthermore, this photosensitizer maintains high activity in the weakly acidic microenvironment of tumors while remaining inactive under normal physiological conditions, thereby achieving intelligent "on-off" regulation based on pH differences, improving the safety and precision of photodynamic therapy for tumors.

The invention discloses a method for continuously synthesizing 5, 5 '-dibromo-2, 2'-bithiophene through twin-screw extrusion, which comprises the following reaction steps: (1) adding 2, 2 '-bithiophene, N-bromosuccinimide and a solid diluent which are uniformly mixed into a feeding bin of a twin-screw extruder; (2) adjusting the feeding speed and the screw rotating speed of the double-screw extruder; and (3) collecting the product, dissolving, filtering, evaporating to remove the solvent and the like to obtain the 5, 5 '-dibromo-2, 2'-bithiophene. According to the present invention, the solvent-free continuous efficient preparation of 5, 5 '-dibromo-2, 2'-bithiophene is achieved by using the twin-screw extrusion technology, the method is green and environmentally friendly, the product yield is increased, and the method has good application prospects.

The present invention provides a method for synthesizing an OLED polycyclic fused thiophene compound, which relates to the field of material synthesis technology. The method comprises the following steps: providing 2-naphthalenesulfonic acid and dichloromethane and mixing them, adding a solution of N-bromosuccinimide dropwise thereto under inert gas protection to obtain intermediate A; dissolving intermediate A, and then adding sodium hydroxide, 4-bromophenylboric acid, water, and tetrakis(triphenylphosphine)palladium thereto to obtain intermediate B; dissolving intermediate B, adding sulfonic acid and phosphorus pentoxide to obtain intermediate C; adding intermediate C to tetrahydrofuran and dissolving it, and then adding lithium aluminum tetrahydride under inert gas to obtain the target compound. The chemical reaction efficiency of intermediate C in this method is high, and the yield and LC purity of the target product are relatively high.

The invention relates to a method of administering radiotherapy to a patient. The method involves producing a radiolabeled aryl drug compound by reacting the aryl boronic acid compound (II) Ar—Y, or a salt thereof, wherein Y is a borono group (—B(OH)2) or an ester group thereof, with a radionuclide selected from 123I, 124I, 125I and 131I, in the presence of an oxidizing agent selected from N-bromosuccinimide and N-chlorosuccinimide, in water, and administering the radiolabeled aryl drug compound to the patient.

The invention discloses a method for synthesizing 2-chlorine-5-chloromethylthiazole and / or 2-chlorine-5-bromomethylthiazole based on a continuous streamer reaction. The method comprises the following steps of: firstly, adding 2-chlorine-5-chloromethylthiazole and / or 2-chlorine-5-bromomethylthiazole; according to the method, 2-chloro-5-methylthiazole and N-chlorosuccinimide (NCS) or N-bromosuccinimide (NBS) are used as raw materials, and the 2-chloro-5-chloromethylthiazole and / or the 2-chloro-5-bromomethylthiazole are / is efficiently synthesized through a photoreactor under the condition of illumination. According to the method, a continuous flow strategy is adopted, so that the reaction yield is increased, the difficulty of light reaction discharge is overcome, meanwhile, a solvent and energy are saved, and a feasible solution is provided for industrial production of 2-chloro-5-chloromethylthiazole and / or 2-chloro-5-bromomethylthiazole.

The application relates to a photosensitizer for type I photodynamic therapy and a preparation method thereof, and belongs to the photosensitizer field. The photosensitizer is obtained through five-step reactions of phenothiazine, n-bromobutane, phosphorus oxychloride, N-bromosuccinimide, 5-aldehyde-2-thiophene boronic acid, 1,4-dimethylpyridine-1-iodonium and potassium hexafluorophosphate, and can effectively generate type I active oxygen in a small molecule state. The photosensitizer has great prospects in the field of type I photodynamic therapy.

The application discloses a two-photon fluorescent dye containing pyridine dicarboxylic acid units, and a preparation method thereof. The dye has the following preparation method: 6-hydroxy-2-naphthaldehyde reacts with a sulfonic acid lactone under the action of an alkaline substance, or reacts with a dihalogenated hydrocarbon to obtain a monohalogenated hydroxyl aryl ether, and then the monohalogenated hydroxyl aryl ether reacts with a sulfite to prepare S1; 4-(4-methylphenyl) pyridine-2,6-dicarboxylic acid diethyl ester reacts with N-bromosuccinimide to obtain a bromide, and then the bromide reacts with triphenylphosphine to prepare S2; intermediates S1 and S2 react under the action of a strong base, and then hydrolysis is carried out to prepare a target product. The dye has good cell membrane permeability, preferentially targets a cell nucleus, is well dispersed in the cell nucleus, has water solubility, has very low toxicity, has a high two-photon absorption interface, and can be applied to two-photon fluorescence confocal microscopic imaging.

The invention discloses a method for preparing deoxycholic acid. Specifically, the preparation method comprises the following steps: step 1, in the presence of a solvent and N-bromosuccinimide, carrying out oxidation reaction on a compound 2 to prepare a compound 3; 2, under the condition of a solvent, the compound 3 and p-toluenesulfonhydrazide are subjected to a condensation reaction, and a compound 4 is prepared; 3, in the presence of a solvent and sodium borohydride, the compound 4 is subjected to a reduction reaction, and deoxycholic acid is prepared. The method is mild in reaction condition, environmentally friendly, high in efficiency, low in cost and suitable for industrial production.

The invention relates to the technical field of analytical chemistry and fluorescence sensing, and discloses an N-bromosuccinimide (NBS) detection method based on a specific fluorescence probe and an application of the N-bromosuccinimide (NBS) detection method. The structure of the fluorescent probe is reported as a polymer monomer to research the aggregation-induced emission property of a polymer, but the reaction activity of the fluorescent probe with NBS is not researched. Besides, in the prior art, NBS detection mainly depends on high performance liquid chromatography (HPLC) or mass spectrometry (MS), and the methods have the defects of expensive equipment, complex operation and the like. The fluorescent material probe disclosed by the invention can realize fluorescence detection of NBS, and is good in selectivity and low in detection limit. On-Off type fluorescence detection shows that the fluorescent solution can effectively react to NBS at different levels, the potential of the fluorescent solution serving as an NBS detection sensor is highlighted, and an effective tool is provided for NBS evaluation in environmental monitoring.

The application relates to the field of coating, and discloses a self-cleaning nano-coating glass plate and a preparation method and application thereof, the nano-coating comprising: silicone resin, epoxy resin, modified nano-titanium dioxide, long-chain alkyl methyl silicone oil, a curing agent and a diluent; the modified nano-titanium dioxide is prepared by grafting modified silane coupling agents prepared by reacting modified phosphorus-containing antibacterial monomers with vinyl triethoxysilane with nano-titanium dioxide; the modified phosphorus-containing antibacterial monomers are prepared by reacting syzygium aromaticum and N-bromosuccinimide, then reacting with 2-amino-4-methylthiazole, and further reacting with diphenyl phosphinic chloride; the obtained phosphorus-containing antibacterial monomers are reacted with 1,1,3,3-tetramethyldisiloxane; the long-chain alkyl methyl silicone oil is prepared by using octamethylcyclotetrasiloxane, dodecyl methyl dimethoxysilane and hexamethyldisiloxane as raw materials; and the nano-coating prepared by the application has a super-hydrophobic surface, and simultaneously has excellent antibacterial property, wear resistance and flame resistance.

Disclosed in the present invention is a method for preparing synthetic precursors for polybrominated biphenyls, which method comprises the following steps: step 1, using 3,5-dibromoaniline as a raw material, reacting same with N-bromosuccinimide in an organic solvent, and purifying the reaction product, so as to obtain 2,3,4,5-tetrabromoaniline and 2,3,4,5,6-pentabromoaniline; and step 2, separately subjecting the 2,3,4,5-tetrabromoaniline and the 2,3,4,5,6-pentabromoaniline prepared in step 1 to a diazotization reaction by means of an aqueous sulfuric acid solution and an aqueous sodium nitrite solution to obtain diazonium salts, and reducing the diazonium salts by means of an aqueous hypophosphorous acid solution, so as to obtain corresponding tetrabromobenzene or pentabromobenzene. In the present invention, commercially available N-bromosuccinimide (NBS) is used as a bromine source, and the raw material can be completely converted, by means of a one-step reaction, into 2,3,4,5-tetrabromoaniline and 2,3,4,5,6-pentabromoaniline, which can be used as synthetic precursors for polybrominated biphenyls; therefore, the cost of synthesis is lower, and good economical efficiency and application value are obtained. Moreover, the present invention is simple in terms of synthesis steps, the products are easy to separate and purify, and the chemical purity of the obtained products reaches 99% or higher.

The invention provides an acrolein fluorescent probe based on a coumarin derivative, a preparation method of the acrolein fluorescent probe and application of the acrolein fluorescent probe in biological detection, and belongs to the field of small organic molecule fluorescent probes. The preparation method of the acrolein fluorescent probe based on the coumarin derivative comprises the following steps: in a solvent environment, carrying out contact reaction on 7-diethylamino coumarin and N-bromosuccinimide to obtain a compound 3; and contacting the compound 3 with 4-aminophenylboronic acid, carrying out a heating reaction, and purifying to prepare the acrolein fluorescent probe based on the coumarin derivative. The acrolein fluorescent probe based on the coumarin derivative is easy and convenient to operate, good in acrolein recognition selectivity, high in response speed, high in sensitivity, good in fluorescence stability and anti-interference performance and capable of rapidly and accurately detecting acrolein in the real-time acrolein detection process; meanwhile, the preparation process of the fluorescent probe is simple, the preparation efficiency is high, and the preparation cost is low.