15results about How to "High chemoselectivity" patented technology

The application discloses a method for synthesizing high-concentration furfuryl alcohol by using a double-enzyme coupling method, and the method comprises the following steps: mixing alcohol dehydrogenase freeze-dried bacterial powder and glucose dehydrogenase freeze-dried bacterial powder to serve as a catalyst, using furfural as a substrate, using glucose as a co-substrate, using NADP + or NAD + as a coenzyme, using a buffer solution with a pH value of 4-9 as a reaction medium to form a reaction system, and reacting completely under the condition of 20-50 DEG C and 400 rpm, then separating and purifying the reaction liquid to obtain furfuryl alcohol. The biological catalytic system is suitable for furfural with a concentration higher than 500 mM, and 100% conversion of 500 mM can be realized within 10 hours. The substrate continuous flow process is further used to eliminate the inhibition of aldehyde substrates on the biological catalyst, the concentration of the product can reach 1500 mM, and the highest space-time yield can reach 235 g / (L.d).

The invention relates to a method for synthesizing trans-isopentenyl substituted indolone under the catalysis of transition metal nickel. Specifically, a metal nickel catalyst (Ni (cod) 2) and tricyclohexylphosphine (PCy3) are used as ligands, C3 unsubstituted indolone is used as a nucleophilic reagent to react with isoprene, and a trans-isopentenyl substituted indolone product is obtained. And then taking the product as a reaction raw material, and carrying out nucleophilic substitution reaction on the product and halogenated alkane under an alkaline condition to obtain the 3, 3-disubstituted indolone with divergent functional groups. According to the invention, isoprene is used as a reaction precursor, a trans-isopentenyl substituted indolone product is obtained with high activity and selectivity, a nucleophilic substitution reaction is relayed, and a new strategy is provided for flexibly and conveniently introducing functional groups with different steric hindrances and electrical properties.

This invention discloses a phosphonothiolated binaphthol derivative and its synthetic method. Using readily available binaphthioonium salts as starting materials, secondary phosphine oxides as coupling agents, and a base as a promoter, a series of phosphonothiolated binaphthol derivatives are generated. This invention features simple raw material preparation, very mild synthetic reaction conditions, convenient experimental operation, high reaction efficiency, and diverse functional groups.

The invention discloses a method for synthesizing a gem-difluoroolefin compound through conversion of alkane under catalysis of acridine. The gem-difluoroolefin is a multifunctional fluorine-containing synthon and is a core unit structure for improving performance in the fields of medicines, pesticides and materials. According to the method, an alpha-trifluoroolefin compound and various alkanes are taken as raw materials, and gem-difluoroallylation is directly realized under the conditions of acridine, alkali and illumination. The method has the advantages of simple preparation operation and wide substrate applicability, and contains various electron-withdrawing or electron-donating groups and various cyclic heterocyclic or non-heterocyclic alkanes. The method is mild in reaction condition, relatively high in yield and simple in subsequent treatment, and is a green chemical synthesis method with a relatively good application prospect.

The invention relates to a photo-initiated synthetic aminophenol compound method and application, and belongs to the technical field of organic synthesis. The synthesis method comprises the following steps: deprotonating a 1-hydroxybenzotriazole compound under an alkaline condition, and carrying out cracking reaction under the excitation of visible light to generate a high-activity biradical intermediate which is unstable and can be rapidly tautomerized into a more stable nitrosobenzene anion intermediate; the intermediate further reacts with cyclohexenone substances to synthesize the aminophenol derivative in one step. The method is simple and efficient, simple and convenient to operate, free of transition metal and additional oxidizing agents, simple and easily available in raw material reagent, high in product yield and capable of realizing large-scale synthesis, and a new method is provided for rapidly synthesizing the aminophenol compound. The synthesized aminophenol compound has good antibacterial activity, and especially has huge potential in the aspect of preventing and treating anthracnose of tea trees.

This invention discloses a method for preparing alkenyl triazole compounds. Under the action of a base, alkynyl sulfonium salts and triazole compounds are reacted in an organic solvent at room temperature and pressure for 2–5 h to obtain alkenyl triazole compounds. This invention utilizes a diamine reaction at room temperature, requiring no additional catalyst or oxidant, exhibiting excellent functional group tolerance and broad substrate applicability, while also demonstrating good chemoselectivity, regioselectivity, and stereoselectivity. The reaction system is free of toxic metal catalysts, simple to operate, and demonstrates excellent functional group tolerance and broad substrate applicability. The raw materials used are inexpensive and readily available, exhibiting good atom economy and step economy, providing a new strategy for the synthesis of triazole series compounds. The entire reaction process is mild, with high product selectivity, simple operation, and environmental friendliness, conforming to the principles of green chemistry.

This application discloses an asymmetric photocatalytic spirocyclic synthesis method for constructing chiral spirocyclic amines, belonging to the field of organic synthesis. This method utilizes a dual-catalyst system composed of chiral phosphoric acid (CPA) and fac-Ir(ppy)3 photosensitizer. Under visible light irradiation, using alkenylsulfonyl oximes I and vinyl azide II substituted with imine-nitro-aromatic hydrocarbons as starting materials, a series of imine-nitro-nitro-aromatic hydrocarbon-functionalized spirocyclic amines were synthesized in high yield and with high enantioselectivity. The key innovation of this invention lies in using a sulfonyl group to replace the traditional ester group to protect the nitrogen atom of the oxime. This improvement promotes the energy transfer (EnT) mechanism rather than the single electron transfer (SET) mechanism. In this way, the reaction efficiency is significantly improved, while providing an ideal reaction environment for chiral hydrogen bonding catalysis.

This invention discloses a method for synthesizing 4,6-bis(trifluoromethyl)-1,3,5-triazabicyclo[3.1.0]hex-2-ene compounds. Using nitrile compounds and diacaridine as raw materials, the method utilizes photo-induced decomposition of diacaridine to efficiently construct the target azabicyclo skeleton. This method features mild reaction conditions and a simple synthetic route. Furthermore, it exhibits broad functional tolerance, mild reaction conditions, high yield, and simple post-processing, making it a promising green chemical synthesis method. The novel skeleton can serve as a novel bioisostere, overcoming the bottlenecks of limited existing skeleton structures and high synthetic difficulty, providing technical support for drug molecule optimization and new drug development.

The invention discloses a reaction composition and a method for constructing a gamma-amino acid skeleton by photopromoted CO2 immobilization. The composition comprises a 1, 1-stilbene compound, an alpha-silicon-based carbazole compound, a photocatalyst, alkali and carbon dioxide. The method comprises the following steps: under visible light irradiation and a carbon dioxide atmosphere, carrying out desiliconization on an alpha-silicon-based carbazole compound to generate alpha-amino carbon free radicals by utilizing a photooxidation reduction catalytic mechanism, and then carrying out addition on a 1, 1-stilbene compound and capturing carbon dioxide, so as to construct a gamma-amino acid skeleton. According to the method, a silicon-based activation strategy is utilized, the use of high temperature, high pressure and a metal catalyst is avoided, the method has the advantages of mild reaction conditions, strong substrate universality, high chemical selectivity and the like, and efficient and green synthesis of the carbazole-containing unnatural amino acid is realized.

The application discloses a kind of methods for the depth separation of indium, belong to nonferrous metallurgy technical field.The method for the depth separation of indium of the application, in view of the problems such as low efficiency of indium separation and extraction in strong acidic, multi-ion coexisting system, poor selectivity and insufficient stability of traditional adsorption material, based on the specific coordination chemical behavior of indium, design and synthesize the organic building unit of indium selectivity, and construct the covalent organic framework material with high crystallinity and high specific surface area by reversible covalent bond self-assembly.Relying on the functional groups uniformly distributed in ordered pore, the material has high-density active sites, excellent chemical stability and multi-level pore structure characteristics, can produce specific recognition and strong coordination effect on indium ions, realize efficient, depth separation and recovery of indium ions under the condition of strong acidity, multi coexisting ions.

The invention belongs to the technical field of synthesis of cephalosporin compounds, and particularly relates to a cephalosporin compound as well as a preparation method and application thereof. The cephalosporin compound is a compound as shown in the following structural general formula, an optical isomer and a pharmaceutically available salt, wherein R is selected from aryl, substituted aryl, 5-to 8-membered heteroaryl, 3-to 8-membered aliphatic ring and bicyclic monoterpene ketone group; the number of substituent groups of the substituted aryl is 1 to 5; substituent groups of the substituted aryl groups are independently selected from C1-C6 alkyl groups, substituted C1-C6 alkyl groups, halogen and cyano groups; the substituent of the substituted C1-C6 alkyl is selected from halogen. According to the invention, the cephalosporin compound and the sulfonyl chloride are used as raw materials for modifying the cephalosporin antibiotics for the first time, so that the antibacterial and anti-inflammatory dual functions are realized, and the effects of inhibiting bacteria and regulating inflammatory response are synchronously exerted.

The invention discloses a preparation method of high-purity dihydrooat alkaloid, which comprises two continuous reaction stages of nucleophilic substitution and electrophilic addition and a post-treatment stage of separation and purification, and comprises the following steps: under the condition of nitrogen protection, carrying out nucleophilic substitution reaction on p-hydroxyphenylpropionic acid and carbonyl diimidazole to generate an N-acyl imidazole active intermediate; dropwise adding into an organic solvent of o-aminobenzoic acid without separation to complete electrophilic addition reaction, so as to generate a dihydrooat alkaloid solution with high selectivity; after the reaction is finished, cooling to room temperature, extracting, separating and concentrating an organic phase to separate out a crude product or concentrating a reaction solution until the reaction solution is dry and separating out a crude product in an acidic aqueous solution, and recrystallizing to obtain the high-purity dihydrooat alkaloid. The one-pot process strategy of step-by-step activation and controllable addition is adopted, the reaction has the advantages of being high in chemical selectivity, mild in reaction condition, high in raw material conversion rate and simple and convenient in aftertreatment, phenolic hydroxyl protection is avoided, the problem of high-selectivity amidation is solved, and the preparation cost is effectively reduced.

The invention discloses a method for synthesizing an organic silicon stabilizer through a one-pot three-step reaction, which is carried out under simple and easy-to-control conditions, trichlorosilane (compound I) is used as a raw material, one-time addition reaction and two-time substitution reaction are carried out by means of a one-pot three-step strategy, further purification is not needed in the process, and the organic silicon stabilizer is synthesized through a one-pot three-step method. Finally, the 3-(2-methyl formate) aminopropyl trimethoxy silane is converted into the 3-(2-methyl formate) aminopropyl trimethoxy silane (compound V). The synthesis of the product can be realized through a one-pot three-step method, and the provided synthesis method has the advantages of high atom economy, high reaction activity, excellent chemical selectivity and the like, so that the preparation method has a wide application prospect.

This invention discloses a monophosphine polymer-embedded catalyst for olefin hydroformylation, its preparation method, and its applications. This monophosphine polymer-embedded catalyst is obtained in one step via solvothermal polymerization of a vinyl-functionalized monophosphine ligand and an active metal precursor. The catalyst prepared by this invention is composed of an active metal and a monophosphine copolymer. This catalyst can both embed the active metal and achieve efficient and highly selective olefin hydroformylation reactions using CO as a carbonyl source under mild conditions. The catalyst of this invention retains the advantages of homogeneous catalysts, such as high catalytic activity and good chemoselectivity, and has a relatively simple synthesis route, relatively low production cost, and easy separation of the catalyst and product. It is suitable for olefin hydroformylation reactions, thus meeting the industrial application requirements of olefin hydroformylation reactions. Furthermore, it allows for the controllable synthesis of aldehydes or alcohols by controlling the temperature.

The application provides a non-classical C-glycoside and a stereospecific synthesis method and application thereof, and the synthesis method comprises the following steps: taking a non-classical sugar-based stannane as a nucleophilic reagent, taking a halogenated hydrocarbon as an electrophilic reagent, and performing a Stille cross-coupling reaction to obtain the non-classical C-glycoside. The non-classical C-glycoside and the stereospecific synthesis method and application thereof provided by the application have the advantages that the synthesis method is simple in process, convenient in operation, high in yield, good in functional group tolerance, strong in stereospecificity, wide in sugar substrate range, and compatible with unprotected sugar and an aqueous phase system; furthermore, the obtained non-classical C-glycoside not only has better antibacterial activity, but also can be used as an active pharmaceutical material, and promotes the technological progress of the pharmaceutical synthesis industry and the pharmaceutical industry.