97results about "Organic reduction" patented technology

The invention discloses a preparation method of hydrogenated benvitimod and analogues thereof, and belongs to the technical field of organic synthesis. The method comprises the following steps: S1, mixing a compound I and palladium carbon in a solvent to obtain slurry; s2, under the protection of nitrogen, preheating the silicon carbide microchannel reactor to 20-70 DEG C, and then introducing hydrogen and the slurry in the step S1; the reaction temperature is 20-70 DEG C, the reaction pressure is 1-10 kg, and the retention time of the slurry is 1-20 min; and S3, carrying out solid-liquid separation, concentration, recrystallization and drying on the reaction liquid in the step S2 to obtain a compound II. The method adopts continuous flow production and is suitable for industrial production; the reaction speed is high, and the residence time does not exceed 20 min and is much shorter than overnight time in the prior art; the reaction yield is high and can reach 95% or above, and the yield of part of compounds can reach 99% or above; the catalyst dosage is small, and the reaction cost is greatly reduced.

The disclosure relates to radiolabeled aromatic electrophile prosthetic groups, which can be used to prepare bioactive ligands containing PET, SPECT, alpha- or beta-emitting radioisotopes, and their use in treating and / or imaging cancer.

A process for the hydrogenation of carbonyl compounds consisting of the following steps: (a) providing hydrogen with a molar share of deuterium ≤ 100 ppm, based on the total hydrogen content, by electrolysis of water using electrical power generated at least in part from non-fossil energy, (b) hydrogenating a carbonyl compound using the hydrogen provided in step (a) to form the corresponding hydrogenation product, wherein at least one carbonyl group of the carbonyl compound is hydrogenated.

Disclosed herein are deuterated compounds and transition metal catalyzed methods for making deuterated compounds. The disclosed methods are regioselective and enantioselective and may be utilized to prepare isomerically and / or enantiomerically pure or enriched deuterated compounds. The disclosed methods also may be modified in order to prepared fluorinated compounds.

The invention discloses a method for dehalogenation reduction of electron-rich aryl halide, which comprises the following step: by taking aryl halide as a raw material, carrying out heating reaction in the presence of phosphorous acid, elemental iodine and a solvent to prepare a corresponding aromatic compound. According to the method, the defect that expensive transition metal catalysts and equivalent metal reagents need to be used for participation in current mainstream methods is directly avoided, the electron-rich aryl halide is subjected to one-step dehalogenation reduction to obtain the corresponding aromatic hydrocarbon by taking low-cost, low-toxicity and relatively stable phosphorous acid as a reducing agent and taking the iodine elementary substance as a catalyst, and the method has the advantages of no metal participation, simple operation, low cost and the like. The method has the advantages of simple operation, low cost, environmental protection and the like, avoids the use of a metal reagent and the limitation that special equipment is not easy to amplify production, after the phosphorous acid reaction is finished, byproducts are generally phosphoric acid and corresponding phosphorus salts thereof and can be quickly removed by washing, the post-treatment is simple, and the method is beneficial to industrial production.

Disclosed is a reducing agent for synthesizing a nitrogen-containing compound, the reducing agent being composed of a metal complex that contains samarium and a multidentate ligand which is coordinated to samarium. The multidentate ligand has 4 to 8 coordinating atoms that are bonded to samarium, and the coordinating atoms are each independently an oxygen atom or a nitrogen atom.

The application discloses a preparation method of a binary transition metal aluminide nanocatalyst and application thereof. First, a mixed metal salt solution is mixed with an ammonium carbonate solution to obtain a metal oxide precursor through co-precipitation. Then, the oxide precursor is mixed with a low-temperature composite molten salt and is subjected to thermal reduction under a specific atmosphere. Through simple post-processing, a single-phase binary transition metal aluminide nanocatalyst with high catalytic activity is obtained. The non-noble metal aluminide nanocatalyst prepared is applied to a reaction of catalytically selectively hydrogenating acetylenes to prepare olefin compounds. Under mild conditions, 99% conversion of reactants is achieved while maintaining 96% olefin selectivity. Compared with a traditional supported catalyst, the metal aluminum atom greatly regulates the electronic and geometric structures of the transition metal atom, effectively improves the catalytic activity, and significantly improves the structural stability of the catalyst. The material has high phase purity, is easy to separate and recycle, and has good application prospect.

The present invention relates to a method for preparing cross-linked lignin in the form of particles using hydrothermal treatment with a liquid made from black liquor, comprising lignin and a cross-linking agent or a precursor thereof, and having an electrical conductivity of more than 15 mS / cm, preferably more than 25 mS / cm to 400 mS / cm. The present invention also relates to cross-linked lignin produced using the above-mentioned method. The present invention also relates to cross-linked lignin particles having a glass transition temperature Tg of at least 160°C or no glass transition temperature and a STSA surface area of at least 10 m 2 / g. The present invention also relates to rubber articles, in particular industrial rubber articles or tires, comprising cross-linked lignin particles as filler.

In a first aspect, the present invention relates to a hydrogenation process for converting a compound comprising reacting the compound in a liquid medium with hydrogen in a reaction vessel included in a reaction apparatus in the presence of a heterogeneous hydrogenation catalyst, the method comprises: (i) transferring at least a portion of the thermal energy generated in the reaction vessel to a heat transfer medium, preferably a heat transfer medium stream HTMS1, in a heat exchanger HE, obtaining a heat transfer medium stream HTMS2, the HTMS2 having an increased thermal energy content compared to HTMS1; and (ii) increasing the pressure of the heat transfer medium stream HTMS2 having the pressure p2, thereby obtaining a heat transfer medium stream HTMS3 having an increased pressure p3 compared to HTMS2. A second aspect of the invention relates to a reaction system for hydrogenation.

[Problem] To perform selective hydrogenolysis of a cyclic compound that has a five-membered ring structure and that is included in a saturated cyclic compound used as a hydrogen carrier. [Solution] A metal catalyst used in hydrogenolysis of a cyclic compound that has a five-membered ring structure and that is included in a saturated cyclic compound used as a hydrogen carrier, comprises: a silica-based carrier as a catalyst carrier; and iridium or rhodium as a metal supported on the catalyst carrier.

This invention is directed to transition metal-based-halloysite nanocomposites and methods of making and using the same.

The present invention provides a supported catalyst, and a preparation method therefor and the use thereof. The catalyst comprises: a modified carbon material having an oxygen-containing functional group, a covering agent and palladium, wherein ID1 / IG=0.1-1.2. The catalyst of the present invention can significantly improve the catalytic efficiency of a palladium-carbon catalyst, and can effectively reduce the residual amount of 4-CBA in a terephthalic acid hydrofining reaction.

The invention discloses a preparation method of a cerium oxide supported palladium catalyst and application of the cerium oxide supported palladium catalyst in catalytic hydrogenation of azo compounds. According to the catalyst, nano octahedral cerium oxide serves as a carrier, palladium is loaded through an impregnation method, and a high-dispersion Pd / CeO catalytic system is formed. The octahedron of cerium oxide and the hydrogenation activity of palladium have a synergistic effect, the hydrogenation efficiency and selectivity of the catalyst are remarkably improved, the catalyst is suitable for hydrogenation reduction reaction of hydrogenated azo compounds, the preparation method of the catalyst is simple, the cost is low, the hydrogenated azo compounds can be efficiently catalyzed under mild conditions, and compared with a traditional Pd / C catalyst, the catalyst has good application prospects. The catalyst has higher activity and stability.

The invention relates to the field of organic synthesis, in particular to a post-treatment method for a catalytic hydrogenation reaction by using a copper-containing catalyst, which comprises the steps of adding an auxiliary agent and standing. According to the method, separation of the copper-containing catalyst and the organic reaction system is promoted in an efficient, economical, simple and convenient manner, on one hand, the purity and stability of catalytic hydrogenation products are improved, on the other hand, more copper-containing catalysts can be recycled, and generation of heavy metal waste is reduced.

Disclosed herein is a PET tracer compound (S)-1-(2-(6-[18F]fluoropyridin-3-yl)-4-(trifluoromethyl)phenyl)-N-(pyrimidin-2-yl)-2,3-dihydro-1H-indene-5-sulfonamide and salts thereof, and uses of the same as imaging agents. Also disclosed are precursor compounds, such as (S)-1-(2-(6-nitropyridin-3-yl)-4-(trifluoromethyl)phenyl)-N-(pyrimidin-2-yl)-2,3-dihydro-1H-indene-5-sulfonamide, and salts thereof. Also disclosed are kits comprising the same.

In a first aspect, the invention relates to a hydrogenation process for the hydrogenation of a compound comprising reacting the compound in a liquid medium with hydrogen in the presence of a heterogeneous hydrogenation catalyst in a reaction vessel, the process comprising: (i) transferring at least a part of the thermal energy generated in the reaction vessel to a cooling medium, preferably a cooling medium stream CMS1, obtaining a cooling medium stream CMS2, which has an increased thermal energy content compared to CMS1; and (ii) transferring at least a part of the thermal energy comprised in cooling medium stream CMS2 to a heat transfer medium stream HTMS1 in a heat pump HP, thereby obtaining a heat transfer medium stream HTMS2, which has an increased thermal energy content compared to HTMS1. A second aspect of the invention is directed to a reaction system for hydrogenation of a compound, preferably for converting a compound having at least one nitro group into the corresponding compound having at least one amino group by hydrogenation.

The invention discloses a method for realizing metal-free catalytic hydrogenation by using a black phosphorus-based catalyst, which comprises the following specific steps: adding an unsaturated compound and a black phosphorus-based catalyst into a high-pressure reaction kettle, adding a solvent, strictly sealing the high-pressure reaction kettle, introducing hydrogen, emptying air in the high-pressure reaction kettle, introducing hydrogen, heating, and reacting while stirring, cooling to room temperature, releasing pressure, filtering to separate out solid and liquid, washing the solid with water and absolute ethyl alcohol in sequence, and drying to obtain the black phosphorus-based catalyst for reuse, the liquid containing a target product. According to the method, the black phosphorus-based catalyst is used as a metal-free catalyst to be applied to the field of catalytic hydrogenation for the first time, catalytic hydrogenation of various unsaturated compounds is successfully achieved, high catalytic activity is achieved, and the inherent defects that a metal-based catalyst is high in cost, prone to poisoning and inactivation and the like can be fundamentally overcome; in addition, the catalyst used in the invention has the advantages of low preparation cost and mild conditions, and is suitable for large-scale industrial production.

The invention belongs to the field of inorganic and organic material design and catalysts, and discloses a metal organic framework material taking a multiphase hindered Lewis acid-base pair as a catalytic site, and preparation and catalytic application of the metal organic framework material. The structural formula of the metal organic framework material taking the multiphase hindered Lewis acid-base pair as the catalytic site is M3 (OH) (L1) 3 (L2) 1; wherein M3 is a three-metal cluster node; l1 is a parent framework composed of carboxylic acid ligands; l2 is a bipyridyl ligand containing a Lewis base; and the Lewis base on the L2 and the metal node form an FLP structure. The method has high capability of activating small molecules. The catalyst has high stability, and can be recycled for multiple times in the semi-hydrogenation reaction of phenylacetylene to maintain the performance. According to the invention, metal nodes, high specific surface area and high porosity in the MOF are fully utilized.

This invention is directed to transition metal-based-halloysite nanocomposites and methods of making and using the same.

The application belongs to the field of catalytic new materials and fine chemical technology, and discloses a preparation method and application of a supported noble metal aluminide nanocatalyst. The application provides a new preparation method and catalyst, and can synthesize a supported noble metal aluminide catalytic material with high activity and high selectivity at a lower temperature, which is used for selective hydrogenation reaction. In particular, the application aims to solve the problems of difficult preparation, easy phase mixing, and insufficient selectivity and stability in hydrogenation reaction of the high-activity supported noble metal aluminide nanocatalyst, thereby significantly improving the catalytic effect. The supported noble metal aluminide nanocatalyst prepared by the application can obtain the performance even better than that of a conventional noble metal catalyst at a lower reaction temperature and pressure, the reaction path is clear, the metal ratio range is adjustable, the synthesis result has high repeatability, and the application provides a new high-efficiency and stable catalytic material for selective hydrogenation.

The invention discloses a direct reductive hydrogenation method of alkyl olefin, which belongs to the technical field of organic compound olefin hydrogenation reaction, and comprises the following steps: in an organic solvent, in the presence of an activator, an HAT reagent and a catalyst, under the illumination condition, directly carrying out reductive hydrogenation reaction on an olefin substrate to prepare a hydrogenated product; the target reduction product can be efficiently obtained without pretreatment or intermediate preparation, and the method has the advantages of good substrate adaptability and functional group compatibility, high yield, excellent purity, low overall cost and good industrial application prospect.

A molecule having a formula (7) for use as a fuel in a combustion engine: and wherein said molecule is a di(2-ethylhexyl) ether.

In the presence of a catalyst and a cycloalkane compound represented by formula (3):wherein R3, R4, R5, R6, R7, R8, R9, and R10 are the same or different and each is a halogen atom, an alkyl group, or a fluoroalkyl group; an alkene compound represented by formula (2):wherein X1, X2, R1, and R2 are as defined above; is reacted with a hydrogen-containing gas to hydrogenate the alkene compound represented by formula (2), whereby an alkane compound represented by R1CHX1CHX2R2, wherein X1 and X2 are the same or different and each is a halogen atom, and R1 and R2 are the same or different and each is an alkyl group or a fluoroalkyl group; can be synthesized in such a manner that (S), (R)-isomer, (R), (R)-isomer, and (S), (S)-isomer are co-produced.

Disclosed are neuroactive steroid anaesthetic agents, methods for their preparation and compositions comprising the same. The invention provides scaled up and / or GMP methods for preparing neuroactive steroids, such as alfaxalone, alfadolone and alfadolone acetate.

The present invention relates to the use of a specific homogenous catalyst for the partial (selective) hydrogenation of a carbon-carbon triple bond.

According to the World Health Organization, 7 million people die annually due to inhaling exhaust gases containing SO2 and NOX from power plants. The majority of these emissions come from fossil fuel combustion in thermal power plants and diesel engines. Industrial development is necessary for providing electricity, but the growth in societies will lead to an increase in pollution. Existing filters are costly, discouraging power plants from using them. This invention prevents smoke from power plants, ships, and locomotives from entering the atmosphere. The process involves removing vaporized particles and converting SO2 gas into sulfuric acid, which can be used in various industries. The remaining gases, including NOX, are converted into nitric acid and other useful compounds through a series of steps. The final output contains only minimal CO gas, which can be controlled through improved oxidation methods in fuel combustion.

This invention utilizes mechanical vapor compression and / or thermal vapor compression, integrating compression loops across multiple process stages. A sequential network of compressors is used to increase the pressure and condensation temperature of vapor within each process stage as an internal vapor flow, and as an inter-vapor flow branching between process stages. Because available vapor is shared between compressor stages, the number of compressors can be reduced, improving economics. By separating vapor between compressor stages to balance the vapor mass flow rate across multiple process stages in the incremental compressor stages, the entire vapor compression system can be customized to individual process energy requirements and adapt to dynamic fluctuations in process conditions.

Disclosed herein is a PET tracer compound (S)-1-(2-(6-[18F]fluoropyridin-3-yl)-4-(trifluoromethyl)phenyl)-N-(pyrimidin-2-yl)-2,3-dihydro-1H-indene-5-sulfonamide and salts thereof, and uses of the same as imaging agents. Also disclosed are precursor compounds, such as (S)-1-(2-(6-nitropyridin-3-yl)-4-(trifluoromethyl)phenyl)-N-(pyrimidin-2-yl)-2,3-dihydro-1H-indene-5-sulfonamide, and salts thereof. Also disclosed are kits comprising the same.