28results about How to "Particle size controllable" patented technology

The invention belongs to the technical field of cosmetics, and particularly relates to a cosmetic delivery system based on a natural wall material, a preparation method and application. The cosmetic delivery system is of a core-shell structure, a core is a cosmetic active component, and a shell layer is a composite polymer gel network of sodium alginate, sophorolipid and cellulose. The natural polysaccharide composite wall material is green and safe, has good biocompatibility and strong compatibility with cosmetic formulas, and does not irritate the skin. The delivery system can effectively protect cosmetic active ingredients from being damaged by illumination and oxygen, and the storage stability of the active ingredients is remarkably improved; meanwhile, slow release and targeted transdermal absorption of active ingredients are realized, and the bioavailability is improved.

This invention discloses silicon carbide particles and their preparation method, relating to the field of semiconductor technology. Silicon carbide particles with controllable particle size are prepared using a reaction system including a fluidized bed, with an average particle size of 3mm-11mm. The fluidized bed includes nozzles on the inner side of a cone wall, and the focusing point and flow rate of the fluid ejected from the nozzles are set. By controlling the flow rate of the fluid ejected from the nozzles, the particle size of the finished product is precisely controlled, reducing the defect rate caused by substandard particle size and achieving a high particle size yield. The product has controllable particle size and high purity, avoiding the risks introduced by crushing and screening. Furthermore, the production process does not require the disassembly and assembly of a single furnace, enabling continuous production, simplifying the production process, reducing input costs, ensuring product quality, and improving production efficiency, providing a new approach for future industrialization.

The invention relates to the technical field of immune carriers, in particular to immune carrier microspheres loaded with individualized MHC-II binding polypeptide and vaccine preparation and application of the immune carrier microspheres loaded with the individualized MHC-II binding polypeptide. The core microsphere is loaded with individualized MHC-II binding polypeptide, the sequence of the MHC-II binding polypeptide is obtained by predicting and screening based on an HLA genotyping result, and each HLA allele corresponds to at least one high-affinity MHC-II binding polypeptide; and the shell is a glucan or other polymer coating layer. The preparation method has the advantages that the T epitope and the B epitope are separately subjected to immune competitive inhibition inside and outside the microspheres, so that a better immune effect is obtained. The antibody avoids cross reaction side effects; carrier molecule diversity is reduced, and side effects caused by T cell over-activation are avoided; th1 epitopes and Th2 epitopes can be contained in the microspheres, so that antibody immunity and T cell immunity functions are generated; the particle size of the microspheres is controllable, and the immunologic function can be achieved without adjuvants.

The application discloses a method for preparing mesoporous zeolite under normal temperature and pressure and application thereof, and the preparation method comprises the following steps: (1) preparation of a functional protein biomodule: cationic polypeptide is loaded on yeast to obtain a biomodule aqueous solution; (2) deposition of silicon and aluminum: the pH of the biomodule solution obtained in the step (1) is adjusted to neutral, then a silicon source, an aluminum source and a titanium source are added into the solution, and the solution is incubated on a shaking table for 3 days; (3) calcination: the solid obtained in the step (2) is collected by centrifugation, washed with ethanol and water alternately for 3 times, and calcined at 500 DEG C for 4h under an air atmosphere to obtain a zeolite molecular sieve adsorption material. The application can prepare porous molecular sieve small balls by using a simple method, and can provide a brand-new thought for synthesizing molecular sieve materials.

This invention relates to the field of oral care products technology, specifically to an artificial enzyme with antibacterial properties, its preparation method, and its application. This technical solution employs a chemical reduction method, where a palladium source reacts in an environment containing surfactants and reducing agents to obtain palladium nanozymes. The obtained palladium nanozymes exhibit uniform morphology, controllable particle size, good dispersibility in water, and good biocompatibility; they have no significant toxic side effects on human gingival fibroblasts, possess highly efficient catalase activity, and demonstrate strong antibacterial and bactericidal effects against oral pathogens, significantly reducing bacterial drug resistance; they can inhibit acid production by oral bacteria, preventing tooth decay; and they retain their original catalytic activity even after multiple cycles of use. Applying the palladium nanozymes of this solution to the manufacture of oral care products can solve the technical problems of unsatisfactory safety and easy development of drug resistance in existing oral care products using antibacterial and anti-caries methods, showing promising application prospects.

The application relates to a multifunctional spherical Prussian blue nanolaser and a preparation method and application thereof, and belongs to the field of nanobiological materials and biological medicine. The nanolaser takes spherical Prussian blue nanoparticles as a main body structure, has good near-infrared photothermal response performance and active oxygen (ROS) removal capacity, and can improve the superoxide dismutase (SOD)-like catalytic activity and antioxidant performance by doping metal elements such as ruthenium, bismuth and manganese. The nanolaser can generate a mild photothermal effect of 38-45 DEG C under near-infrared laser irradiation, and cooperatively remove excessive active oxygen in an inflammatory microenvironment, thereby reducing the expression of inflammatory factors and matrix metalloproteinases, inhibiting the activation of the iezo1 / Piezo2 / MMP13-related inflammatory and matrix degradation pathways, and relieving oxidative stress damage and inflammatory reactions. The nanolaser has the characteristics of uniform particle size, good dispersibility, high stability and excellent biocompatibility, and can be used for the prevention of diseases such as osteoarthritis and rheumatoid arthritis. The application constructs a nanolaser system with mild photothermal regulation and antioxidant activity.

This invention discloses a method for preparing zeolite molecular sieves with precisely adjustable particle size, comprising the following steps: (1) adding aluminum source and other raw materials to deionized water and stirring evenly at room temperature; (2) adding silicon source, stirring at room temperature, and then adding template agent to obtain precursor slurry; (3) adding zeolite molecular sieve, the amount of zeolite molecular sieve being 1-15 mg / g of precursor slurry, transferring the precursor slurry to a high-pressure reactor, fixing it on a homogeneous reactor, heating to 0-150℃, maintaining for 1-200 h, and then heating to 160-230℃ for 3 hours to crystallize for 6-96 h; (4) obtaining zeolite molecular sieve after centrifugal washing, drying, and calcination. The innovation of the preparation method of this invention lies in the first use of a two-stage synthesis method, which can gradually reduce the particle size of the zeolite molecular sieve product while increasing the yield of zeolite molecular sieves. This method successfully synthesized SAPO-34 zeolite molecular sieve with a particle size deviation of less than 0.4 μm and ZSM-5 zeolite molecular sieve with a particle size deviation of less than 0.2 μm.

The invention discloses ship lock large-volume air-entraining concrete and a pouring vibration exhaust method, and belongs to the technical field of concrete.The ship lock large-volume air-entraining concrete is prepared from 130-160 kg / m < 3 > of cement, 50-70 kg / m < 3 > of fly ash, 50-70 kg / m < 3 > of mineral powder, 600-750 kg / m < 3 > of sand, 1300-1500 kg / m < 3 > of gravel, 3-5 kg / m < 3 > of a water reducing agent, 90-130 kg / m < 3 > of water and 3-4 kg / m < 3 > of an air-entraining anti-cracking agent according to the mixing proportion; a nano-scale super absorbent material is adopted as an air-entraining anti-cracking agent, internal humidity is maintained and a temperature peak value is reduced through water absorption and slow water release, and corresponding nano micropores are reserved in a microstructure through water release and polymer shrinkage, so that the effects of enhancing mechanical properties and resisting cracking after air entraining are achieved.

The invention provides a preparation method of collagen microspheres, which comprises the following steps: dissolving collagen in an acid solution to obtain a first solution; dissolving an inert macromolecular crowding agent in water to obtain a second solution; obtaining an oil phase; respectively injecting the first solution, the second solution and the oil phase into a first channel, a second channel and a third channel of a three-channel microfluidic device; pressure is applied to the first channel, the second channel and the third channel, so that the first solution sequentially flows through the first junction of the first channel and the second channel and the second junction of the first channel and the third channel in the first channel; and collecting effluent at the outlet of the first channel to obtain the collagen microspheres. The invention also provides a collagen microsphere. The collagen microsphere comprises collagen, an inert macromolecular crowding agent and an oil phase. According to the method provided by the invention, uniform particle size of the microspheres can be ensured in the preparation process; toxic and harmful components are not added; and mass production of microspheres can be realized, and the industrialization degree is high.

The invention discloses a natural polymer-based slow-release oxygen microcapsule for repairing sediments as well as a preparation method and application of the natural polymer-based slow-release oxygen microcapsule. The slow-release oxygen microcapsule prepared by a micro-fluidic method comprises an oxygen release core containing calcium peroxide, sodium alginate and carboxymethyl chitosan are used as natural polymer shell materials, and the size of the slow-release oxygen microcapsule is 0.1-2 mm. The sodium alginate is subjected to ionic crosslinking between carboxyl and calcium ions to form an eggshell-shaped initial gel network; further, carboxymethyl chitosan is subjected to a Schiff base reaction through glutaraldehyde, and a second stable network is constructed; the two polymer chains form a composite shell layer with a stable structure and adjustable permeability through the synergistic effect of physical entanglement and double crosslinking points. The structure can effectively block water molecule permeation and oxygen diffusion, and long-acting release of oxygen is achieved.

The invention discloses a method and a device for synthesizing lithium sulfide with a controllable particle size. The method comprises the following steps: S1, dissolving lithium sulfide; performing evaporation concentration and low-temperature drying to obtain a lithium hydrosulfide powder raw material; s2, introducing high-purity hydrogen sulfide gas into a crushing and mixing chamber, and further crushing and fully mixing under strong impact of high-speed jet flow; s3, performing vulcanization reaction through the fluidized bed reaction chamber to obtain high-purity lithium sulfide particles; and S4, after synthesis is completed, transferring into a glove box. Compared with the prior art, the method disclosed by the invention has the advantages that the ethanol is adopted as a solvent, the uniformity of a lithium sulfide initial blank shell can be ensured to the greatest extent through a recrystallization method, and the high-quality lithium sulfide with controllable particle size can be obtained more quickly by accurately controlling the pressure of high-speed jet flow and regulating and controlling the particle size of a precursor material through the crushing and mixing chamber; the purity is higher, the particle size distribution is more uniform, the operation process is simple, convenient and feasible, and the method is suitable for large-scale industrial production.

The invention relates to a poly-L-lactic acid microsphere used for a drug delivery system and having a controllable degradation rate and a preparation method and application thereof.The preparation method comprises the steps that an oil-phase organic solution is added into an emulsifier aqueous solution through an SPG film to be stirred for a reaction, and a poly-L-lactic acid microsphere crude product is obtained; sequentially mixing and reacting the L-polylactic acid microsphere crude product with a sodium hydroxide solution and a polylysine solution, washing and freeze-drying to obtain L-polylactic acid microspheres; a solute in the oil-phase organic solution comprises poly-L-lactic acid and a lactic acid-glycolic acid-polyvinyl alcohol block copolymer. The poly-L-lactic acid microsphere material obtained through a specific preparation process has good stability and biocompatibility, is controllable in degradation rate, and is suitable for preparing a drug delivery system, so that the drug curative effect is improved, and the drug administration frequency is reduced.

The invention discloses a process and a method for preparing a nano material. Specifically, lithium iron phosphate, composite sodium iron phosphate and calcium carbonate are efficiently prepared by adopting a sol-gel method and a precipitation method respectively. When the lithium iron phosphate and the composite sodium iron phosphate are prepared, the reaction process is controllable by regulating and controlling the oscillation condition, the reaction temperature, the pH value and the retention time, and a target product is obtained after the gel is calcined. When calcium carbonate is prepared, nucleation and crystallization are enhanced by controlling the flow rates of a precursor, a precipitator and a surfactant and combining oscillation. According to the method, mixed mass transfer is enhanced by means of periodic oscillatory flow, local supersaturation and concentration gradient are inhibited, reactant deposition and channel blockage are reduced, continuous and stable production is guaranteed, meanwhile, the use amount and cost of a surfactant are reduced, and accurate regulation and control over the particle size, morphology and distribution of the material are achieved. Compared with a traditional process, the preparation period is greatly shortened, the product purity and the reaction efficiency are improved, and the method is suitable for industrial continuous production and has remarkable economic benefits and social benefits.

This invention discloses a glycosyl carbon quantum dot oil displacement agent for unconventional oil reservoirs, its preparation method, and its application, belonging to the field of oilfield chemical technology. The preparation of the glycosyl carbon quantum dot oil displacement agent for unconventional oil reservoirs of this invention includes: adding a carbon source and a modifier to an alcohol solution, stirring to dissolve, and then carrying out a hydrothermal reaction to obtain the product; wherein the modifier is a ketoxime modifier; this method is simple, low-cost, has controllable particle size, and high yield, making it suitable for industrial application; the obtained carbon quantum dots have a high specific surface area and functional groups such as carboxyl and hydroxyl groups, which can penetrate nanopores and synergistically reduce the oil-water interfacial tension to below 5.0 mN / m; this product has outstanding high-temperature resistance and penetration ability, and can effectively penetrate into the nanopore throat structure of tight reservoirs, significantly improving oil displacement efficiency through interfacial modification, and is particularly suitable for the exploitation of unconventional nano-oil and gas resources.

This invention discloses a sintered spherical mullite-zirconia composite high-temperature kiln lining material, belonging to the field of high-temperature resistant materials technology. It is prepared by sintering mesoporous spherical mullite particles as the matrix and zirconia hollow fibers as the reinforcing phase. This material belongs to advanced inorganic non-metallic materials and is a fireproof and heat-insulating special brick and tile material, suitable for use in energy-saving furnaces, high-temperature kilns, and other equipment. The combination of mesoporous spherical mullite particles and zirconia hollow fibers significantly increases the apparent porosity of the material, thereby reducing its bulk density and thermal conductivity; and the zirconia hollow fibers significantly enhance the material's strength.

The application provides a granular ion sieve and a preparation method and application thereof, and the preparation method comprises the following steps: (1) dissolving a polymer monomer in an organic solvent to obtain an oil phase, mixing the oil phase with ion sieve powder, and performing a prepolymerization reaction and slurry under stirring to obtain a prepolymer; (2) mixing the prepolymer obtained in the step (1) with an aqueous phase containing a high molecular dispersant, and performing a suspension polymerization reaction to obtain the granular ion sieve. Through the method of simultaneously performing the prepolymerization and the slurry, the ion sieve powder can be thoroughly mixed with the polymer monomer, and the ion sieve powder is not easy to diffuse into the aqueous phase in the polymerization process, the process stability and product performance are improved, and the granular ion sieve prepared has a balling rate of greater than 70% in a qualified particle size range 。

This invention discloses a surface-modified high-pressure SiO2 x The preparation method of this invention includes the following steps: preparation of a carbon layer precursor by controlling the reaction time to prepare spherical carbon layer precursors of different sizes; thorough mixing of the carbon layer precursor with a silicon source and aging of the mixed solution; filtration and washing of the reaction solution followed by drying in a vacuum drying oven, and then sintering under an inert atmosphere to obtain multilayer carbon-coated SiO2. x Materials; SiO2 prepared by the technical solution of this invention x The material has a higher compaction density, thus reducing matrix pulverization. Meanwhile, the SiO₂ prepared by this invention... x The number of carbon shell layers in the material can be controlled, suppressing volume changes during charging and discharging.

The application discloses a preparation method of silicon nitride nano-powder, relates to the technical field of inorganic non-metallic nano-material preparation, and is characterized by a direct nitriding reaction link of silicon vapor and nitrogen plasma. The method uses high-purity silicon vapor prepared by an existing process as raw material, introduces the high-purity silicon vapor into a nitrogen plasma reaction area, and under specific process conditions, the silicon vapor and the nitrogen plasma rapidly generate a nitriding reaction to form a silicon nitride nano-particle precursor. After condensation, collection and simple subsequent treatment, high-purity silicon nitride nano-powder is obtained. The core reaction link of the application does not need to prepare a solid silicon powder intermediate, has high reaction efficiency, high product purity and good dispersity, solves the problems of easy agglomeration and high impurity content of silicon nitride powder in the prior art, and the product can be applied to high-end fields such as high-temperature structural ceramics and semiconductor packaging.

The present application belongs to the field of gene drug delivery, and particularly relates to a kind of lipid compound with glutaric acid skeleton and lipid carrier, nucleic acid lipid nanoparticle composition and pharmaceutical preparation based thereon.The compound with the structure of formula (I) of the present application can be prepared into lipid carrier alone or together with other lipid compounds.The lipid carrier has high encapsulation efficiency for nucleic acid drugs, which helps to improve the delivery efficiency of nucleic acid drugs in vivo;Multiple biodegradable functional groups are contained, so that the lipid metabolism is fast, and the biological safety is high.Moreover, the lipid carrier can also deliver nucleic acid drugs to organs that need to be enriched, and has good application prospect.

This invention provides an MC-type carbide-reinforced Nb-based alloy spherical powder, its preparation method, and its application, belonging to the field of metal material preparation technology. The invention involves distributing the MC-type carbide-reinforced Nb-based alloy spherical powder according to its composition, followed by suspension induction melting and casting to obtain a master alloy ingot. The master alloy ingot is then machined to obtain an Nb-based alloy electrode rod. Using the Nb-based alloy electrode rod as raw material, powder is produced by plasma rotating electrode atomization to obtain the MC-type carbide-reinforced Nb-based alloy spherical powder. The MC-type carbide-reinforced Nb-based alloy spherical powder prepared by the method of this invention has uniform composition, controllable particle size with a narrow distribution range, good sphericity, low O and N content, and high purity, making it suitable for additive manufacturing.

The application provides a preparation method of organic microspheres. The preparation method comprises the following steps: preparing a first organic polymer seed emulsion by using a vertical reaction kettle with baffles on the inner wall, then adding the seed emulsion into a second organic polymer emulsion, and continuously stirring in the vertical reaction kettle with baffles on the inner wall to obtain the organic microspheres. The method can obtain stable and particle size controllable organic microspheres.

The application provides a method for in-situ combustion synthesis of high-purity nanometer silicon carbide powder, and belongs to the technical field of inorganic nanometer material preparation, and comprises the following steps: placing water-soluble saccharide substances, gel monomers, water-soluble solutions of a crosslinking agent and an initiator into ion exchange columns respectively for filtration purification, then mixing the water-soluble saccharide substances, the gel material and high-purity silicon powder to form a sol, further carrying out in-situ gel solidification and pre-carbonization treatment to obtain a Si / C composite material block; carrying out combustion synthesis reaction on the obtained Si / C composite material, grinding the obtained block-shaped product to obtain the high-purity nanometer silicon carbide powder. The high-purity carbon source and the silicon source are fixed by the gel network, the silicon powder is uniformly embedded in the carbon skeleton, uniform dispersion and close combination of the two are realized, and the in-situ combustion synthesis reaction is efficiently promoted. The raw material cost in the application is low, the preparation process is simple, the environment is friendly, and the application is suitable for industrialized large-scale production of high-purity nanometer silicon carbide powder.

The invention discloses a method for preparing monodisperse silicon dioxide microspheres with controllable particle size based on a seed growth method, which combines a Stber method with a sodium silicate precipitation method, ensures the monodispersity of initial seeds by using the Stber method, and realizes subsequent low-cost and large-scale growth by using sodium silicate. The method effectively solves the problems of high cost and complicated steps during amplification production of a traditional Stber method. According to the method, reaction kinetics are accurately controlled, so that the problem of explosive homogeneous nucleation caused by violent change of pH in a traditional sodium silicate method is effectively solved. The generation rate of the silicate ions is always lower than the heterogeneous deposition rate of the silicate ions on the surfaces of the seeds, so that secondary nucleation is thoroughly inhibited, and pure heterogeneous growth of silicon species on the surfaces of the seeds is completely realized. The method not only ensures that the final product inherits the monodispersity of the seed, but also realizes accurate and controllable amplification of the particle size of the microsphere, and finally obtains the silicon dioxide microsphere with excellent monodispersity and controllable particle size.

This invention discloses a modified organic black dye and its preparation method, relating to the field of dye modification technology. The preparation method includes the following steps: (1) chemically modifying the organic black dye with a linker to obtain a modified black dye; (2) preparing polymer microspheres using a soap-free emulsion polymerization method; (3) chemically bonding the modified black dye obtained in step (1) with the polymer microspheres obtained in step (2) to obtain a spherical modified organic black dye. The preparation method of this invention combines the organic black dye with polymer microspheres through chemical bonds to form a spherical dye, improving the dye morphology and enhancing its flowability and dispersion uniformity. Furthermore, the polymer microspheres prepared using the soap-free emulsion polymerization technology of this invention have controllable particle size and good monodispersity, resulting in uniform particle size of the final dye particles, making them suitable for applications with strict particle size requirements.

The application discloses a composite seed for inducing target ion reaction in water and a preparation method and application thereof, and belongs to the technical field of water treatment. The preparation method of the composite seed is as follows: target cations and target anions are selected according to target ions to be reacted; a porous carrier is soaked in a first solution containing the target cations; a second solution containing the target anions is added dropwise under stirring, and the dropping speed is controlled to make the supersaturation degree of the system lower than the critical supersaturation degree of homogeneous nucleation, so as to force the target cations and the target anions to react on the inner surface of the pores of the carrier, generate nanocrystal nuclei in situ and grow; and the composite seed is obtained through aging, solid-liquid separation, washing and drying. The nanocrystal nuclei have the same crystal structure as the composition of the target ions to be reacted. Through the in-situ loading process, the nanocrystal nuclei are firmly loaded in the pores of the porous carrier, and the target crystal nucleus design is combined, so that the reaction efficiency of the fluidized bed is remarkably improved, the activity of the crystal nucleus is long-lasting, and the composite seed has a good industrial application prospect.

The application discloses a preparation method of modified nanometer carbon material and a lithium ion battery. An equipment for implementing the preparation method comprises a feeding machine, an air flow pulverizer and a magnetic field removing machine arranged in sequence along a material running direction, and the air flow pulverizer and the magnetic field removing machine are arranged in sequence from top to bottom along a height direction. The preparation method comprises the following steps: in step 1, nanometer carbon material and modified material are mixed according to a mass ratio of 100:0.1-5, and then the mixture is fed into the air flow pulverizer through the feeding machine, wherein the modified material comprises a polymer and a small molecule amine, and the mass ratio of the polymer to the small molecule amine is 100:5-10; and in step 2, after the material is pulverized by the air flow pulverizer, the material is fed into the magnetic field removing machine in a free fall mode under the action of gravity to remove the magnetic field. The nanometer carbon material has better dispersity and lower metal impurity content.

This invention discloses a bioactive nanomicelle based on idebenone. By designing idebenone molecules with hydrophobic ends and functionalized hydrophilic polyethylene glycol, it exhibits excellent responsiveness, antioxidant properties, and cellular safety, making it suitable as a carrier for delivering drugs, genes, or other bioactive molecules for therapeutic and diagnostic applications. This invention also discloses a method for preparing this idebenone-based bioactive nanomicelle. The method for synthesizing the amphiphilic polymer of IDBP is simple, with mild reaction conditions, easy synthesis, convenient post-processing, high yield, and easy industrial production. The prepared amphiphilic polymer exhibits spontaneous assembly behavior in aqueous solution, forming a stable nanomicelle structure. This demonstrates the great potential of idebenone-based bioactive nanomicelles in drug delivery, potentially improving drug stability, bioavailability, and targeting.

This invention discloses a method for preparing a microcapsule-structured specialty coffee extract, the extract itself, and its applications, belonging to the field of fragrance and flavor technology. The method includes: adding an emulsifier to the specialty coffee extract and emulsifying it at 1530°C to obtain an emulsion; preheating a melamine resin prepolymer to 4045°C and adding it to the emulsion; raising the temperature to 4550°C within 15 minutes and adjusting the pH to 4.5-5.5 for the first stage reaction; then raising the temperature to 6080°C for the second stage reaction; and finally cooling and adjusting the pH to 7.5-8.5 to terminate the reaction, thus obtaining the microcapsule-structured specialty coffee extract. This invention, through room-temperature emulsification and a two-stage temperature-controlled process, effectively preserves the complex aroma of the specialty coffee extract. The resulting microcapsule structure is dense and stable, possessing both sustained-release and rapid aroma release via friction, significantly extending the aroma retention time. This invention also provides the application of the microcapsule-structured specialty coffee extract in the preparation of pet products.