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Liquid-solid mixed lipid nano-slow release system for cosmetic and preparation method thereof

A nano-sustained release and mixed lipid technology, which is applied in the field of nano-sustained-release system and its preparation, can solve the problems of unseen literature and patent reports, and achieve the effects of improved encapsulation efficiency, good compatibility, and simple operation

Inactive Publication Date: 2012-11-28
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to make the liquid-solid mixed lipid nano drug delivery system applicable to cosmetics, the selected liquid and solid lipids need to have good compatibility with the entire emulsion system of cosmetics, so glyceryl monostearate is used As a solid lipid, isopropyl myristate is a liquid lipid, and a nano-lipid delivery system containing liquid-solid mixed lipids for cosmetics has been prepared. So far, no relevant literature and patent reports have been seen.

Method used

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  • Liquid-solid mixed lipid nano-slow release system for cosmetic and preparation method thereof
  • Liquid-solid mixed lipid nano-slow release system for cosmetic and preparation method thereof
  • Liquid-solid mixed lipid nano-slow release system for cosmetic and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Take 3mL of a commercially available silk peptide aqueous solution (14.5%) sample in a three-necked flask, add 15mL of 6mol L -1 HCl and 2 to 3 drops of phenol, sealed, and vacuum degassed at the same time, N 2 Sealed and protected, heated in an oil bath, hydrolyzed at 150°C for 1.5 hours, after the hydrolysis is complete, the hydrolyzed solution is rotary evaporated to dryness, and the volume is adjusted to the original volume with distilled water, shaken to obtain the silk peptide hydrolyzed solution.

[0037] Accurately weigh 200 mg of the mixed carrier of glyceryl monostearate (solid lipid A), isopropyl myristate (liquid lipid B), and the proportion of liquid lipid B is 5% (w / w ), dispersed in 4 mL of absolute ethanol, added 0.1 mL of silk peptide hydrolyzate, and heated in a water bath at 50 ° C to promote the dissolution of solid lipids. At 400r·min -1 Under the condition of mechanical stirring, the obtained mixture solution (organic phase) was poured into 40 mL...

Embodiment 2

[0053] According to Example 1, the suspension (emulsion) of silk peptide-liquid-solid mixed lipid nanoparticles containing liquid lipid B of 5% (w / w) was prepared, denoted as 1 # ; The blank silk peptide-liquid-solid mixed lipid nanoparticle (containing liquid lipid B is 5%, but does not add silk peptide hydrolyzate when preparing according to Example 1) is ultrasonically dispersed in distilled water, and in this suspension Add the same amount of silk peptide hydrolyzate when preparing Example 1, and the gained mixed emulsion is recorded as 2 # .

[0054] Will 1 # with 2 # The emulsion was subjected to an in vitro moisturizing test (n=3) by in vitro weighing method under two different relative humidity environments, and the results are shown in Table 2.

[0055] Table 2 In vitro moisturizing test results of silk peptide-liquid-solid mixed lipid nano-sustained release system

[0056]

[0057] Table 2 shows that under low humidity (drier environment) conditions, the long-...

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Abstract

The present invention relates to a liquid-solid mixed lipid nano-slow release system for cosmetics and a preparation method thereof. The release system is composed of nanoparticles constituted by liquid lipid and solid lipid and at least one active ingredient coated in the nanoparticles. The preparation method includes: (1) dispersing a mixing carrier of the solid lipid and the liquid lipid to an organic solvent, adding the active ingredient, and heating in a water bath to dissolve the solid lipid to get an organic phase solution; (2) formulating polyvinyl alcohol into an aqueous phase solution, and adjusting the pH to be acidic to get an aqueous phase solution; and (3) adding the organic phase solution to the aqueous phase solution under the conditions of mechanical agitation with stirring to get a mixed lipid dispersion liquid which is then centrifuged and separated to obtain the nano-slow release system. The nano-slow release system is simple in preparation method and high in stability. The dimensions of the particles are in nanoscale, and the particle size is controllable. The entrapment efficiency of the liquid-solid mixed lipid nanoparticles has been greatly improved than simple solid nanoparticles.

Description

technical field [0001] The invention belongs to the field of nano sustained release system and its preparation, in particular to a liquid-solid mixed lipid nano sustained release system for cosmetics and its preparation method. Background technique [0002] Sustained release technology used in cosmetics mainly includes: special emulsification system and lipid carrier. Special emulsification systems mainly include liquid crystal structure emulsions, multiple emulsions, and microemulsions. Lipid carriers are usually composed of bilayer or multilayer phospholipids (such as lecithin). The principle is to replace solid lipids or solid lipid mixtures Prepared from liquid oils in oil-in-water emulsions, they have long been used as an ideal carrier for the delivery of active ingredients in cosmetics. However, there are some defects in its application process, such as low drug loading, burst release effect and poor physical stability. [0003] The limitations of the above-mentioned...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/02A61K8/04A61K8/64A61Q19/00A61Q1/12
Inventor 林苗杨勇
Owner DONGHUA UNIV
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